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JPS5511535A - Peptide derivative and determination of renin activity - Google Patents

Peptide derivative and determination of renin activity

Info

Publication number
JPS5511535A
JPS5511535A JP8419578A JP8419578A JPS5511535A JP S5511535 A JPS5511535 A JP S5511535A JP 8419578 A JP8419578 A JP 8419578A JP 8419578 A JP8419578 A JP 8419578A JP S5511535 A JPS5511535 A JP S5511535A
Authority
JP
Japan
Prior art keywords
amino
peptide derivative
methylcoumarin
determination
renin activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8419578A
Other languages
Japanese (ja)
Other versions
JPS626560B2 (en
Inventor
Shunpei Sakakibara
Kazuo Murakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Priority to JP8419578A priority Critical patent/JPS5511535A/en
Publication of JPS5511535A publication Critical patent/JPS5511535A/en
Publication of JPS626560B2 publication Critical patent/JPS626560B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A peptide derivative of the formula (R is H, amino-protecting group, or arginyl-prolyl-pheylalanyl-histidyl group).
EXAMPLE: 7-( N-tert-Butyloxycarbonyl-0-2, 6-dichlorobenzyl-L-tyrosyl )-amino-4- methylcoumarin.
USE: Useful as fluorescent substrates for determining the enzyme renin activity or an intermediate for their synthesis. For the determination, a liquid containing renin is brought into contact with a peptide derivative, and the product is subjected to the action of an enzyme to liberate 7-amino-4-methylcoumarin, which is determined.
PROCESS: A tyrosine having protected N and O atoms is condensed with 7-amino-4- methylcoumarin through dehydration, and the N-and O-protecting groups are eliminated from the condensate. The product is then condensed with valine and leucine to give the compound of formula.
COPYRIGHT: (C)1980,JPO&Japio
JP8419578A 1978-07-11 1978-07-11 Peptide derivative and determination of renin activity Granted JPS5511535A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8419578A JPS5511535A (en) 1978-07-11 1978-07-11 Peptide derivative and determination of renin activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8419578A JPS5511535A (en) 1978-07-11 1978-07-11 Peptide derivative and determination of renin activity

Publications (2)

Publication Number Publication Date
JPS5511535A true JPS5511535A (en) 1980-01-26
JPS626560B2 JPS626560B2 (en) 1987-02-12

Family

ID=13823680

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8419578A Granted JPS5511535A (en) 1978-07-11 1978-07-11 Peptide derivative and determination of renin activity

Country Status (1)

Country Link
JP (1) JPS5511535A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945260A (en) * 1982-09-06 1984-03-14 泉陽機工株式会社 Vehicle conveyor
JPS59134052A (en) * 1983-01-10 1984-08-01 リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・ミネソタ Changeover mechanism for car

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5945260A (en) * 1982-09-06 1984-03-14 泉陽機工株式会社 Vehicle conveyor
JPS59134052A (en) * 1983-01-10 1984-08-01 リ−ジエンツ・オブ・ザ・ユニバ−シテイ・オブ・ミネソタ Changeover mechanism for car

Also Published As

Publication number Publication date
JPS626560B2 (en) 1987-02-12

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