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JPS5479286A - Preparation of 5-fluoro-orotic acid - Google Patents

Preparation of 5-fluoro-orotic acid

Info

Publication number
JPS5479286A
JPS5479286A JP14400977A JP14400977A JPS5479286A JP S5479286 A JPS5479286 A JP S5479286A JP 14400977 A JP14400977 A JP 14400977A JP 14400977 A JP14400977 A JP 14400977A JP S5479286 A JPS5479286 A JP S5479286A
Authority
JP
Japan
Prior art keywords
orotic acid
acid
fluoro
formic acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP14400977A
Other languages
Japanese (ja)
Other versions
JPS615477B2 (en
Inventor
Yoshio Oda
Keiichi Uchida
Shinsuke Morikawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Priority to JP14400977A priority Critical patent/JPS5479286A/en
Publication of JPS5479286A publication Critical patent/JPS5479286A/en
Publication of JPS615477B2 publication Critical patent/JPS615477B2/ja
Granted legal-status Critical Current

Links

Abstract

PURPOSE: To obtain the title compound useful as a raw material for various medicines, e.g. oncostatic drugs, etc. with a high utilization of gas at a high selectivity industrially advantageously, by reacting orotic acid with fluorine gas in an available formic acid medium.
CONSTITUTION: Fluorine gas diluted to 0.5-50 times, preferably 1-10 times, with an inert gas is reacted with orotic acid in formic acid at 5W50°C to give an intermediate product (adduct) of formula I, which is then heated in water at 90°C or above, or in air at 100W160°C to form 5-fluoro orotic acid of formula II. The molar dilution ratio of formic acid to orotic acid is 1W1,000:1, preferably 20W100:1.
COPYRIGHT: (C)1979,JPO&Japio
JP14400977A 1977-12-02 1977-12-02 Preparation of 5-fluoro-orotic acid Granted JPS5479286A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP14400977A JPS5479286A (en) 1977-12-02 1977-12-02 Preparation of 5-fluoro-orotic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14400977A JPS5479286A (en) 1977-12-02 1977-12-02 Preparation of 5-fluoro-orotic acid

Publications (2)

Publication Number Publication Date
JPS5479286A true JPS5479286A (en) 1979-06-25
JPS615477B2 JPS615477B2 (en) 1986-02-18

Family

ID=15352185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14400977A Granted JPS5479286A (en) 1977-12-02 1977-12-02 Preparation of 5-fluoro-orotic acid

Country Status (1)

Country Link
JP (1) JPS5479286A (en)

Also Published As

Publication number Publication date
JPS615477B2 (en) 1986-02-18

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