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JPS5430160A - Novel indoleacetoxyacetylamino acid compound * production thereof and medical use - Google Patents

Novel indoleacetoxyacetylamino acid compound * production thereof and medical use

Info

Publication number
JPS5430160A
JPS5430160A JP9469878A JP9469878A JPS5430160A JP S5430160 A JPS5430160 A JP S5430160A JP 9469878 A JP9469878 A JP 9469878A JP 9469878 A JP9469878 A JP 9469878A JP S5430160 A JPS5430160 A JP S5430160A
Authority
JP
Japan
Prior art keywords
indoleacetoxyacetylamino
novel
production
acid compound
medical use
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9469878A
Other languages
Japanese (ja)
Inventor
Borutsue Kaaruuhaintsu
Deru Hansuudeiitaa
Yakobi Hairedodeinku
Opitsu Borufuganku
Shierunhamaa Giyuntaa
Fuoruburehito Deiitaa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Publication of JPS5430160A publication Critical patent/JPS5430160A/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0815—Tripeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP9469878A 1977-08-06 1978-08-04 Novel indoleacetoxyacetylamino acid compound * production thereof and medical use Pending JPS5430160A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772735537 DE2735537A1 (en) 1977-08-06 1977-08-06 INDOLACETOXYACETYLAMINO ACID DERIVATIVES, METHOD FOR THEIR MANUFACTURING AND USE AS A MEDICINAL PRODUCT

Publications (1)

Publication Number Publication Date
JPS5430160A true JPS5430160A (en) 1979-03-06

Family

ID=6015810

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9469878A Pending JPS5430160A (en) 1977-08-06 1978-08-04 Novel indoleacetoxyacetylamino acid compound * production thereof and medical use

Country Status (4)

Country Link
EP (1) EP0000741B1 (en)
JP (1) JPS5430160A (en)
DE (2) DE2735537A1 (en)
IT (1) IT7826537A0 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164572A (en) * 1982-02-26 1983-09-29 トロポンベルケ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・カンパニ−・コマンジツト・ゲゼルシヤフト Manufacture of 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-3-indole acetoxyacetic acids
JPS61112830U (en) * 1984-12-26 1986-07-17

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3034005C2 (en) * 1980-09-10 1982-12-09 A. Nattermann & Cie GmbH, 5000 Köln Indole acetic acid derivatives, process for their preparation and pharmaceutical preparations containing them
DE3206885A1 (en) * 1982-02-26 1983-09-15 Troponwerke GmbH & Co KG, 5000 Köln INDOLDER DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
JPS59204172A (en) * 1983-04-28 1984-11-19 Kowa Co Preparation of acemetacin
WO1990000545A1 (en) * 1988-07-05 1990-01-25 Zeria Pharmaceutical Co., Ltd. Indoleacetic acid derivatives, process for their preparation, and medicines containing same as active ingredients
US6762182B1 (en) 1999-01-07 2004-07-13 Vanderbilt University Converting cox inhibition compounds that are not COX-2 selective inhibitors to derivatives that are COX-2 selective inhibitors
US6207700B1 (en) 1999-01-07 2001-03-27 Vanderbilt University Amide derivatives for antiangiogenic and/or antitumorigenic use
US6306890B1 (en) 1999-08-30 2001-10-23 Vanderbilt University Esters derived from indolealkanols and novel amides derived from indolealkylamides that are selective COX-2 inhibitors
CA2562783A1 (en) 2004-04-26 2005-12-01 Vanderbilt University Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
WO2007149456A2 (en) 2006-06-19 2007-12-27 Vanderbilt University Methods and compositions for diagnostic and therapeutic targeting of cox-2
EP3078374B1 (en) 2011-10-17 2019-06-19 Vanderbilt University Indomethacin analogs for the treatment of castrate-resistant prostate cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2234651C3 (en) * 1972-07-14 1978-11-09 Troponwerke Gmbh & Co Kg, 5000 Koeln Square brackets on l- (p-chlorobenzoyl) -5-methoxy-2-methyl-3-indole] -acetoxj acetic acid, its salts with bases, processes for their production and pharmacological preparations
DE2413125C2 (en) * 1974-03-15 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen Indolylacetylamino acid derivatives, processes for their production and medicinal preparations containing these compounds

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58164572A (en) * 1982-02-26 1983-09-29 トロポンベルケ・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング・ウント・カンパニ−・コマンジツト・ゲゼルシヤフト Manufacture of 1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-3-indole acetoxyacetic acids
JPH0254826B2 (en) * 1982-02-26 1990-11-22 Troponwerke Gmbh & Co Kg
JPS61112830U (en) * 1984-12-26 1986-07-17
JPH0417306Y2 (en) * 1984-12-26 1992-04-17

Also Published As

Publication number Publication date
EP0000741A2 (en) 1979-02-21
EP0000741A3 (en) 1979-03-07
IT7826537A0 (en) 1978-08-04
DE2735537A1 (en) 1979-02-22
DE2860858D1 (en) 1981-10-29
EP0000741B1 (en) 1981-07-22

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