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JPS54106430A - Novel preparation of lysophosphatidylcholine analog - Google Patents

Novel preparation of lysophosphatidylcholine analog

Info

Publication number
JPS54106430A
JPS54106430A JP1197878A JP1197878A JPS54106430A JP S54106430 A JPS54106430 A JP S54106430A JP 1197878 A JP1197878 A JP 1197878A JP 1197878 A JP1197878 A JP 1197878A JP S54106430 A JPS54106430 A JP S54106430A
Authority
JP
Japan
Prior art keywords
analog
lysophosphatidylcholine
novel preparation
alcoholysis
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP1197878A
Other languages
Japanese (ja)
Other versions
JPS6033399B2 (en
Inventor
Hiroshi Kodama
Masao Nakabayashi
Takashi Nagai
Isao Myokan
Kiyoyoshi Tsunekawa
Tetsuya Kajita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toyama Chemical Co Ltd
Original Assignee
Toyama Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd filed Critical Toyama Chemical Co Ltd
Priority to JP1197878A priority Critical patent/JPS6033399B2/en
Publication of JPS54106430A publication Critical patent/JPS54106430A/en
Publication of JPS6033399B2 publication Critical patent/JPS6033399B2/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound having immuno-activating and carcinostatic activities, in a single step and in high yield, by the alcoholysis of phosphatidylcholine analog in the presence of a secondary or tertiary amine and an inorganic salt.
CONSTITUTION: A lysophosphatidylcholine analog of formula II (R1,2 are aliphatic hydrocarbon group; R3W5 are H, 1W4C alkyl) is prepared by the alcoholysis of a phosphatidylcholine analog of formula I at 50W140°C for 30min. to 5 hours, in the presence of a secondary or tertiary amine such as diethylamine, triethylamine, etc., and an inorganic salt such as MgCl2, CaCl2, etc.
COPYRIGHT: (C)1979,JPO&Japio
JP1197878A 1978-02-07 1978-02-07 Novel production method for lysophosphatidylcholine analogs Expired JPS6033399B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1197878A JPS6033399B2 (en) 1978-02-07 1978-02-07 Novel production method for lysophosphatidylcholine analogs

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1197878A JPS6033399B2 (en) 1978-02-07 1978-02-07 Novel production method for lysophosphatidylcholine analogs

Publications (2)

Publication Number Publication Date
JPS54106430A true JPS54106430A (en) 1979-08-21
JPS6033399B2 JPS6033399B2 (en) 1985-08-02

Family

ID=11792683

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1197878A Expired JPS6033399B2 (en) 1978-02-07 1978-02-07 Novel production method for lysophosphatidylcholine analogs

Country Status (1)

Country Link
JP (1) JPS6033399B2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504474A (en) * 1980-06-27 1985-03-12 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
US4551446A (en) * 1980-06-27 1985-11-05 Board Of Regents, The University Of Texas System Use of synthetic phosphoglycerides possessing platelet activating properties as desensitizing agents
JPH01203330A (en) * 1988-02-05 1989-08-16 Rikagaku Kenkyusho anticancer drug
KR100842159B1 (en) 2002-03-25 2008-06-27 주식회사 바이오시너젠 Compositions for the prevention and treatment of acute respiratory distress syndrome and multiple organ failure, including lysophosphatidylcholine or the like

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63169694A (en) * 1987-01-07 1988-07-13 ヤマハ株式会社 Musical sound generator

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4504474A (en) * 1980-06-27 1985-03-12 Board Of Regents, The University Of Texas System Synthetic phosphoglycerides possessing platelet activating properties
US4551446A (en) * 1980-06-27 1985-11-05 Board Of Regents, The University Of Texas System Use of synthetic phosphoglycerides possessing platelet activating properties as desensitizing agents
JPH01203330A (en) * 1988-02-05 1989-08-16 Rikagaku Kenkyusho anticancer drug
KR100842159B1 (en) 2002-03-25 2008-06-27 주식회사 바이오시너젠 Compositions for the prevention and treatment of acute respiratory distress syndrome and multiple organ failure, including lysophosphatidylcholine or the like

Also Published As

Publication number Publication date
JPS6033399B2 (en) 1985-08-02

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