JPH1192326A - Skin preparation for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin preparation for external use, having excellent skin- whitening effect and useful as a cosmetic, medicine or the like having high safety by including one or more kinds of ascorbic acid or the like, and glutathione. SOLUTION: This skin preparation contains (A) preferably 0.001-20 wt.% one or more kinds of compounds selected from L-ascorbic acid or its derivative (e.g. L-ascorbic acid phosphoric acid ester magnesium salt), an extract of placenta (e.g. purified water extract of bovine placenta), kojic acid and its derivative, glycoside of hydroquinone (e.g. hydroquinone β-D-glucose) and its derivative, tranexamic acid and its derivative and ellagic acid and (B) preferably 0.001-20 wt.% glutathione. The skin preparation for external use is utilized as ointment, cream, milk lotion or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to an external preparation for skin. More specifically, the present invention relates to a highly safe skin external preparation having a significantly improved skin whitening effect.

[0002]

2. Description of the Related Art The mechanism of the occurrence of skin spots and the like is unknown, but in general, melamine pigments are formed due to abnormal hormones and irritation of ultraviolet rays from sunlight, and these are formed in the skin. It is thought to be an abnormal deposit.

[0003] Treatment of such spots and bruises includes a method of administering a large amount of a substance that suppresses the production of melanin, for example, L-ascorbic acid, or a method of applying kojic acid or cysteine to an ointment, cream, lotion or the like. As a form, a method such as topical application is used.

[0004]

However, most of these have problems in stability, safety, odor and the like, and the expected effects are weak and have not been satisfactory yet.

In view of such circumstances, the present inventors have conducted intensive studies to obtain a skin external preparation having a truly excellent skin lightening effect. As a result, L-ascorbic acid and its derivatives,
Placental extract, kojic acid and its derivatives, azelaic acid and its derivatives, glucosamine and its derivatives, hydroquinone glycosides and its derivatives, tranexamic acid and its derivatives, one or more selected from the group consisting of ellagic acid And the use of glutathione in combination increased the whitening effect synergistically, and completed the present invention.

An object of the present invention is to provide a skin external preparation having an excellent whitening effect.

[0007]

That is, the present invention provides an L
-Selected from the group consisting of ascorbic acid and its derivatives, placental extract, kojic acid and its derivatives, azelaic acid and its derivatives, glucosamine and its derivatives, hydroquinone glycosides and its derivatives, tranexamic acid and its derivatives, and ellagic acid It is intended to provide an external preparation for skin, characterized by containing one or more selected types of glutathione and glutathione.

[0008] The present invention also relates to the present invention, wherein the L-ascorbic acid and the derivative thereof are L-ascorbic acid, L-ascorbic acid phosphate, L-ascorbic acid-2-sulfate, L-ascorbic acid 2-glucoside or It is intended to provide the above-mentioned external preparation for skin, which is a salt thereof.

Further, the present invention provides the aforementioned external preparation for skin, wherein the glycoside of hydroquinone is hydroquinone β-D-glucose.

The present invention also relates to the above-mentioned L-ascorbic acid and its derivatives, placental extract, kojic acid and its derivatives, azelaic acid and its derivatives, glucosamine and its derivatives, glycosides of hydroquinone and its derivatives, tranexamic acid And the content of one or more selected from the group consisting of:
001 to 20% by weight of the skin external preparation.

Furthermore, the present invention provides the above external preparation for skin, wherein the content of glutathione is 0.001 to 20% by weight based on the total amount of the external preparation for skin.

[0012]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The configuration of the present invention will be described below in detail.

[0013] L-ascorbic acid used in the present invention is generally called vitamin C, and has a strong reductive action to have a cell respiratory action, an enzyme activating action, a collagen-forming action and a melanin reducing action.

Examples of the derivatives of L-ascorbic acid include L-ascorbic acid monostearate and L-ascorbic acid monostearate.
L-ascorbic acid monoalkyl esters such as L-ascorbic acid monopalmitate, L-ascorbic acid monooleate, L-ascorbic acid monophosphate, L
L-ascorbic acid monoester derivatives such as ascorbic acid-2-sulfate, L-ascorbic acid distearate, L-ascorbic acid dipalmitate, L
-Dialkyl esters such as ascorbic acid dioleate and L- such as L-ascorbic acid diphosphate.
Ascorbic acid diesters, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate,
Examples thereof include trialkyl esters such as L-ascorbic acid triolate, ascorbic acid triesters such as L-ascorbic acid triphosphate, and further, ascorbic acid glucosides such as L-ascorbic acid 2-glucoside. .

The placenta extract used in the present invention includes an extract obtained by extracting bovine or porcine placenta with purified water, an extract obtained by subjecting bovine placenta to proteolytic enzyme treatment and extracting with purified water, and a sheep extract. An extract obtained by subjecting the placenta to an enzyme treatment and extracting with purified water can be used.

The kojic acid derivative used in the present invention includes:
For example, kojic acid esters such as kojic acid alkyl ester and kojic acid ethers such as kojic acid alkyl ether can be exemplified.

The azelaic acid derivative used in the present invention includes, for example, azelaic acid monoesters such as azelaic acid monoalkyl ester, and azelaic acid diesters such as azelaic acid dialkyl ester.

The glucosamine derivatives used in the present invention include, for example, glucosamine esters such as acetylglucosamine and glucosamine ethers such as glucosamine methyl ether.

Examples of the hydroquinone glycoside used in the present invention include hydroquinone α-D-glucose,
Hydroquinone β-D-glucose, hydroquinone α
Hexacarbon sugar glycosides such as L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, hydroquinone α -D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-
Ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β-D-
Arabinose, hydroquinone α-L-arabinose,
Pentose glycosides such as hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β-L-glucosamine, hydroquinone α-D-galactosamine, Amino sugar glycosides such as hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β-D-glucuronic acid, hydroquinone α-L-glucuron Acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid,
Examples include uronic acid glycosides such as hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, and hydroquinone β-L-galacturonic acid. Ether forms such as chlorides can be mentioned, but from the viewpoint of whitening effect, availability, stability and the like, hydroquinone β-D-glucose (generic name: arbutin, hereinafter referred to as arbutin) can be used. Use is preferred.

The tranexamic acid derivative used in the present invention includes, for example, a dimer of tranexamic acid (trans
-4- (trans-aminomethylcyclohexanecarbonyl) aminomethylcyclohexanecarboxylic acid), an ester form of tranexamic acid and hydroquinone (trans-4-
Aminomethylcyclohexanecarboxylic acid 4'-hydroxyphenyl ester), ester form of tranexamic acid and gentisic acid (2- (trans-4-aminomethylcyclohexylcarbonyloxy) -5-hydroxybenzoic acid and salts thereof), amide of tranexamic acid (Trans-4-aminomethylcyclohexanecarboxylic acid methylamide and salts thereof, trans-4- (P-methoxybenzoyl) aminomethylcyclohexanecarboxylic acid and salts thereof, trans-4
-Guanidinomethylcyclohexanecarboxylic acid and salts thereof).

The external preparation for skin of the present invention includes the above-mentioned L-ascorbic acid and its derivatives, placental extract, kojic acid and its derivatives, azelaic acid and its derivatives, glucosamine and its derivatives, hydroquinone glycoside and its Any one or more of the derivative, tranexamic acid and its derivative, and ellagic acid are appropriately selected and blended.

L-ascorbic acid and its derivatives, placental extract, kojic acid and its derivatives, azelaic acid and its derivatives, glucosamine and its derivatives, hydroquinone glycoside and its derivatives, which are blended in the skin external preparation of the present invention , Tranexamic acid and its derivatives, and ellagic acid, the amount of one or more selected from the group is not particularly limited.
001 to 20% by weight, preferably 0.01 to 10% by weight, particularly preferably 0.1 to 7% by weight. If the amount is less than 0.001% by weight, the skin whitening effect of the skin external preparation tends to be poor. Conversely, if the amount exceeds 20% by weight, the effect cannot be substantially increased and the skin external preparation is not expected. Also tends to be difficult.

Glutathione used in the present invention is the most abundant SH compound in the living body, and has the function of reacting with proteins and other disulfides enzymatically and non-enzymatically to maintain the SH. It is a substance that is converted to oxidized glutathione.

The amount of glutathione incorporated in the external preparation for skin of the present invention is not particularly limited, but is generally 0.001 to 20% by weight, preferably 0.01 to 7% by weight based on the total amount of the external preparation for skin. % By weight. This compounding amount is 0.001
When the amount is less than 20% by weight, the whitening effect of the external preparation for skin and the effect of suppressing the skin irritation of the external preparation tend to be poor. Conversely, even if the amount exceeds 20% by weight, the effect cannot be substantially expected. In addition, it tends to be difficult to incorporate it into a skin external preparation.

In addition to the above-mentioned essential components, the skin external preparation of the present invention usually contains other components used in skin external preparations such as cosmetics and pharmaceuticals, such as oils, wetting agents, ultraviolet absorbers, antioxidants, and the like. Agents, surfactants, preservatives, humectants, fragrances,
Water, alcohol, a thickener, and the like can be appropriately added as needed.

The dosage form of the external preparation for skin according to the present invention is arbitrary, for example, a solubilizing system such as a lotion, an emulsifying system such as an emulsion or cream, or an ointment or a dispersion. be able to.

The external preparation for skin of the present invention refers to an external preparation applied to the outer skin as cosmetics, pharmaceuticals, and quasi-drugs, and is used, for example, as an ointment, cream, emulsion, lotion, pack, bath agent and the like. You.

[0028]

EXAMPLES Next, the present invention will be described in more detail with reference to examples, but it goes without saying that the technical scope of the present invention is not limited to these examples. In addition, in the following examples, the compounding amount is% by weight.

First, the method of testing and evaluating the effect of the external preparation for skin of the present invention will be described. The whitening effect was determined from use tests such as the skin whitening effect due to the cumulative application, the removal of spots and freckles.

(1) Whitening effect (Test method) A subject suffering from darkness, spots, freckles, etc.
One sample lotion was applied to the face every day for three months in the morning and evening, and the whitening effect was examined after three months. Examples 1 to 8 and Comparative Example 1 were formulated according to the formulations shown in Table 1.
~ 7 skin external preparations were produced and tested for their effectiveness. The results are shown in "Table 2".

"Examples 1 to 8, Comparative Examples 1 to 9: External preparation for skin" (alcohol phase) 95% by weight of ethyl alcohol 25.0 Polyoxyethylene (25 mol) hydrogenated castor oil ether 2.0 Preservative Agent / antioxidant qs perfume qs drugs (listed in "Table 1") amount shown in table 1 (aqueous phase) Glycerin 2.0 propylene glycol 1.0 ion-exchanged water balance (production method) Solubilize after preparation.

[0032]

[Table 1] ---------------------------------------------- ------------------------ Compounding amount (% by weight) ----------------------- ---------------------------------------------- Example Comparative example 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 9 --------------------------------- ------------------------------------ Phosphoric acid ester of L-ascorbic acid 1----- --2--------Nesium salt ------------------------------------- ----------------------------- Placenta extract ^* -1-------2------ -------------------------------------------------- ---------------------------------------------- -------------------------------------------------- -------- Aseline acid---1-------2---------------------------------- -------------------------------------------------------------------------------------------------- ---2---------------------------------------------- ------------------------ -Alphtin-----1-------2----------------------------------- ------------------------------------- Tranexamic acid------1---- ---2---------------------------------------------- ------------------------- Eraic acid--------1-------2---------- -------------------------------------------------- ------------------------------------------------ ----------------------------------------------- Placenta extract: As the placenta extract in each Example, a purified water extract of bovine placenta was used.

(Evaluation Criteria) Significant Effect: Pigmentation became almost inconspicuous. Effective: Very thin. Somewhat effective: Somewhat thin. Invalid: No change. (Judgment) ：: When the ratio (effective rate) showing excellent and effective among test subjects is 80% or more. ：: When the ratio (effective rate) showing significant effect and effectiveness among test subjects is 50% or more and less than 80%. Δ: When the proportion (effective rate) of the test subjects showing significant effect and effectiveness is 30% or more and less than 50%. X: When the ratio (effective rate) showing significant effect and effectiveness among test subjects is less than 30%.

[0034]

[Table 2] ---------------------------------------------- -------------------------- Example Comparison Example 1 2 3 4 5 6 7 8 1 2 3 4 5 6 7 8 9- -------------------------------------------------- --------------------- Whitening effect ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ × × △ × × △ △ △ △ ---------- -------------------------------------------------- ------------

As is clear from Table 2, the skin external preparations of the examples in which glutathione was used in combination with the drugs used in the comparative examples exhibited a synergistically superior skin whitening effect as compared with the comparative examples. Admitted.

The following is another example of the skin external preparation of the present invention.

Example 9 Vanishing Cream Stearic acid 5.0 Stearic alcohol 4.0 Stearic acid butyl alcohol ester 8.0 Glycerin monostearate 2.0 Ascorbic acid distearate 1.0 Propylene glycol 10.0 Glutathione 1. 0 Preservative / Antioxidant Appropriate amount Fragrance Appropriate amount Ion-exchanged water residue (Preparation method) Glutathione and propylene glycol are added to ion-exchanged water, dissolved, heated and maintained at 70 ° C (aqueous phase).
The other components are mixed, melted by heating and kept at 70 ° C. (oil phase).
The oil phase is gradually added to the water phase, and after the addition is completed, the temperature is maintained for a while to cause a reaction. Thereafter, the mixture is uniformly emulsified with a homomixer and cooled to 30 ° C. while stirring well.

Example 10 Vanishing Cream Stearic Acid 6.0 Sorbitan Monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan Monostearate 1.5 Arbutin 7.0 Propylene Glycol 10.0 Glutathione 5 0.0 Preservative / Antioxidant Appropriate amount Fragrance Appropriate amount Ion-exchanged water residue (Preparation method) Glutathione, arbutin and propylene glycol are added to ion-exchanged water and heated to 70 ° C (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, and after uniform emulsification with a homomixer, the mixture is cooled to 30 ° C. while stirring well.

Example 11 Neutral Cream Stearyl Alcohol 7.0 Stearic Acid 2.0 Hydrogenated Lanolin 2.0 Squalane 5.0 2-Octyldo Deserial Call 6.0 Polyoxyethylene (25 mol) Cetyl Alcohol Ether 3.0 Glycerin monostearate 2.0 Placenta extract 0.1 Propylene glycol 5.0 Glutathione 10.0 Perfume Appropriate amount Preservative / antioxidant Appropriate amount Ion-exchanged water Residue (Production method) To ion-exchanged water Glutathione, placenta extract and propylene glycol are added and heated to 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is added to the water phase to perform preliminary emulsification, and after uniform emulsification with a homomixer, the mixture is cooled to 30 ° C. while stirring well.

Example 12 Cold Cream Solid Paraffin 5.0 Beeswax 10.0 Vaseline 15.0 Liquid Paraffin 41.0 Glycerin Monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan Monolaurate 2 0.0 Kojic acid 2.0 Soap powder 0.1 Borax 0.2 Glutathione 0.1 Ion-exchanged water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount (Production method) Glutathione, kojic acid, soap powder in ion-exchanged water And borosand are added and dissolved by heating, and kept at 70 ° C. (aqueous phase). The other components are mixed, melted by heating and kept at 70 ° C. (oil phase). The oil phase is gradually added to the aqueous phase while stirring to carry out the reaction. After the completion of the reaction, the mixture is uniformly emulsified with a homomixer, and cooled to 30 ° C. while stirring well after emulsification.

Example 13 Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Arbutin 2.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Glutathione 20.0 Ion exchange water Residue (Preparation method) Glutathione and arbutin are dissolved by heating in ion-exchanged water and ethanol, and a water-soluble component of propylene glycol or less is further dissolved, and kept at 70 ° C. (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). Add the oil phase to the water phase, pre-emulsify, homogenize with a homomixer, and after emulsification, stir well at 30 ° C.
Cool down to

Example 14 Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Sodium ascorbic acid-2-sulfate 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Glutathione 7.0 Ion-exchanged water Residue (Preparation method) Glutathione is heated and dissolved in ion-exchanged water and ethanol, and a water-soluble component of propylene glycol or less is further dissolved, and kept at 70 ° C (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, preliminarily emulsified, and uniformly emulsified by a homomixer. After emulsification, the mixture is cooled to 30 ° C. while stirring well.

Example 15 Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl alcohol 1.0 Silicone KF96 (20cs) (manufactured by Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Glycerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Placental extract 5.0 Glutathione 7.0 ions Exchanged water residue (Preparation method) Glutathione and placenta extract are dissolved in ion-exchanged water and ethanol by heating, and water-soluble components such as propylene glycol or less are further dissolved and kept at 70 ° C (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). Add oil phase to water phase, pre-emulsify, homogenize uniformly with homomixer, and after emulsification, stir well
Cool to ° C.

Example 16 Emulsion Polyoxyethylene (20 mol) Polyoxypropylene (2 mol) Cetyl Alcohol 1.0 Silicone KF96 (20cs) (Shin-Etsu Chemical Co., Ltd.) 2.0 Liquid paraffin (medium viscosity) 0 Propylene glycol 5.0 Glucerin 2.0 Ethyl alcohol 15.0 Carboxyvinyl polymer 0.3 Hydroxypropylcellulose 0.1 2-Aminomethylpropanol 0.1 Preservative Appropriate amount Kojic acid 3.0 Glutathione 3.0 Ion exchange Water residue (Preparation method) Glutathione and kojic acid are dissolved in ion-exchanged water and ethanol by heating, and water-soluble components such as propylene glycol or less are dissolved, and the mixture is kept at 70 ° C (aqueous phase). The other oil components are mixed, heated and melted and kept at 70 ° C. (oil phase). Add oil phase to water phase, pre-emulsify, homogenize uniformly with homomixer, and after emulsification, stir well
Cool to ° C.

Example 17 Emulsion Stearic acid 1.5 Cetyl alcohol 0.5 Beeswax 2.0 Polyoxyethylene (20 mol) monooleate 1.0 Glycerin monostearate 1.0 Quince seed extract (5% aqueous solution) 20.0 Ethyl alcohol 10.0 Arbutin 20.0 Propylene glycol 5.0 Glutathione 1.0 Ion-exchanged water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount (Production method) Glutathione in ion-exchanged water , Arbutin and propylene glycol are added and dissolved by heating, and kept at 70 ° C (aqueous phase). Add flavor to ethyl alcohol and dissolve (alcohol phase). Other components except the quince seed extract are mixed, heated and melted, and kept at 70 ° C. (oil phase). The oil phase is added to the water phase, pre-emulsified, and homogenized uniformly with a homomixer. While stirring, add the alcohol phase and the quince seed extract. Then, cool to 30 ° C with stirring.

Example 18 Emulsion Microcrystalline Wax 1.0 Beeswax 2.0 Lanolin 2.0 Liquid Paraffin 20.0 Squalane 10.0 Sorbitan Sesquioleate 4.0 Polyoxyethylene (20 mol) Sorbitan Mono Oleic acid ester 1.0 Arbutin 5.0 Kojic acid 5.0 Propylene glycol 7.0 Glutathione 2.0 Ion exchange water Residual perfume Appropriate amount Preservative / antioxidant Appropriate amount (Production method) Glutathione and arbutin in ion exchange water , Kojic acid and propylene glycol are added and heated to 70 ° C
(Aqueous phase). Mix and heat other components to 70 ° C
(Oil phase). While stirring the oil phase, the aqueous phase is gradually added to the oil phase, and the mixture is uniformly emulsified with a homomixer. After emulsification, cool to 30 ° C with good stirring.

Example 19 Jelly 95% ethyl alcohol 10.0 dipropylene glycol 15.0 polyoxyethylene (15 mol) oleyl alcohol ether 2.0 arbutin 0.5 ascorbic acid distearate 0.5 carboxyvinyl polymer (Product name: Carbopol 941) 1.0 Caustic potash 0.15 L-arginine 0.1 Glutathione 1.0 Fragrance Appropriate amount Preservative Appropriate amount Ion-exchanged water residue (Production method) Glutathione, L-ascorbic acid in ion-exchanged water 2-glucoside, arbutin and carbopol 94
1 is dissolved uniformly, while dipropylene glycol, polyoxyethylene (15 mol) oleyl alcohol ether and other components are dissolved in 95% ethanol and added to the aqueous phase. Next, it is neutralized with caustic potash and L-arginine to increase the viscosity.

Example 20 Peel-off Pack (Alcohol Phase) 95% Ethanol 10.0 Polyoxyethylene (15 mol) Oleyl Alcohol Ether 2.0 Preservatives Appropriate Perfume Appropriate (Aqueous Phase) Glutathione 3.0 Arbutin 1.0 Polyvinyl alcohol 12.0 Glycerin 3.0 Polyethylene glycol 1500 1.0 Ion-exchanged water Residue (Preparation method) Prepare an aqueous phase at 80 ° C, and cool to 50 ° C.
Next, the alcohol phase prepared at room temperature is added, mixed uniformly, and allowed to cool.

Example 21 Pack with Powder (Alcohol Phase) 95% Ethanol 2.0 Preservatives Appropriate Perfume Appropriate Coloring Appropriate Appropriate Ascorbate Dioleate 1.0 (Aqueous Phase) Glutathione 7.0 Arbutin 1.0 Propylene glycol 7.0 Zinc flower 25.0 Kaolin 20.0 Ion-exchanged water Residue (Preparation method) A homogeneous aqueous phase is prepared at room temperature. Next, the alcohol phase prepared at room temperature is added and mixed uniformly.

Example 22 Water Absorbing Ointment Vaseline 40.0 Stearyl Alcohol 18.0 Mokurou 20.0 Polyoxyethylene (10 mol) Monooleate 0.25 Glycerin Monostearate 0.25 Ellagic Acid 1.0 Glutathione 10.0 Ion-exchanged water residue (Preparation method) Glutathione and ellagic acid are added to ion-exchanged water and kept at 70 ° C (aqueous phase). Other components are mixed and dissolved at 70 ° C. (oil phase). The oil phase is added to the aqueous phase, and the mixture is uniformly emulsified with a homomixer and then cooled.

The skin external preparations obtained in the above Examples showed excellent whitening effects in the whitening effect tests conducted in Examples 1 to 8.

[0052]

According to the present invention, L-ascorbic acid and its derivatives, placenta extract, kojic acid and its derivatives,
Azelaic acid and its derivative, glucosamine and its derivative, hydroquinone glycoside and its derivative, tranexamic acid and its derivative, one or more selected from the group consisting of ellagic acid, and by containing glutathione, It is possible to provide a highly safe skin external preparation having a significantly improved skin whitening effect.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 31/19 A61K 31/19 31/34 31/34 31/35 31/35 31/375 31/375 31/70 31/70 35/50 ADA 35/50 ADA

Claims (5)

[Claims] 1. L-ascorbic acid and its derivative, placenta extract, kojic acid and its derivative, azelaic acid and its derivative, glucosamine and its derivative, hydroquinone glycoside and its derivative, tranexamic acid and its derivative, Ellag An external preparation for skin, comprising one or more selected from the group consisting of acids and glutathione. 2. The method according to claim 1, wherein the L-ascorbic acid and its derivatives are L-ascorbic acid, L-ascorbic acid phosphate, L-ascorbic acid-2-sulfate, L-ascorbic acid-2-sulfate,
2. The external preparation for skin according to claim 1, which is ascorbic acid 2-glucoside or a salt thereof. 3. The external preparation for skin according to claim 1, wherein the glycoside of hydroquinone is hydroquinone β-D-glucose. 4. The L-ascorbic acid and its derivative, placental extract, kojic acid and its derivative, azelaic acid and its derivative, glucosamine and its derivative, hydroquinone glycoside and its derivative, tranexamic acid and its derivative, One or more selected from the group consisting of ellagic acid is 0.00 in the total amount of the external preparation for skin.
The external preparation for skin according to claim 1, 2 or 3, wherein the content is 1 to 20% by weight. 5. The external preparation for skin according to claim 1, wherein the content of glutathione is 0.001 to 20% by weight based on the total amount of the external preparation for skin.