JPH11349463A - Composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composition for oral cavity, having high cleaning power and excellent in persistency of dental plaque formation-suppressing effect. SOLUTION: This composition for oral cavity is obtained by combinedly using a synthetic amorphous titanium-bound silicate containing 0.5-15 wt.% (as TiO2 ) titanium binding amount based on SiO2 and containing 3.0-12.0 mol/ mol.% free alkali metal (M) as M/SiO2 with an enzyme.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an oral composition having excellent plaque formation inhibitory effect.

[0002]

2. Description of the Related Art In recent years,
Due to changes in eating habits, an increase in the number of dentists, an increase in the number of times of tooth brushing, and the incorporation of active ingredients in dentifrices, the number of patients with severe caries has been decreasing year by year. However, if you do not decompose the plaque in the area where the toothbrush does not reach and control its formation,
It is hardly linked to the reduction of caries. Therefore, in order to decompose and suppress plaque on a high-risk part where caries is likely to occur, a more effective oral composition is required.

[0003] As a base for providing a cleaning effect used in oral compositions, various substances such as calcium carbonate, aluminum hydroxide, dibasic calcium phosphate, anhydrous calcium phosphate, and hydroxyapatite have been used. Those using acids are becoming mainstream. However, since the amount of silicic anhydride that can be incorporated into the oral composition is smaller than other bases, the number of times particles collide with the teeth is small and high cleanability is required. For this reason, it is required for a composition for oral cavity to decompose plaque efficiently.

[0004] In order to solve this problem, generally,
Although a method of adjusting the amount of silicic anhydride in the oral composition and physically increasing the cleaning power is employed, the amount that can be incorporated into the oral composition is limited due to the amount of silicic acid absorbed. In addition, various advanced techniques are required only because they affect the physical properties and palatability of the oral composition.

The present invention has been made in view of the above circumstances, and it is an object of the present invention to provide an oral composition having a high cleaning effect and a plaque formation-suppressing effect.

[0006]

Means for Solving the Problems and Embodiments of the Invention The present inventors have conducted intensive studies in order to achieve the above object, and as a result, titanium has been found to be 0.5% of TiO ₂ with respect to SiO _2.
~ 15% by weight (calculated as TiO ₂ , hereinafter the same unless otherwise specified) and free alkali metal (M)
Amorphous titanium-bonded silicate containing 3.0 to 12.0 mol / mol% as M / SiO ₂ was used as an abrasive base, and an enzyme such as dextranase and mutanase was combined therewith. The present inventors have found that an oral composition having an excellent cleaning effect, a sustained enzyme activity, and an excellent plaque formation inhibitory effect can be obtained, and the present invention has been accomplished.

Now, the present invention will be described in further detail. The oral composition of the present invention includes dentifrices such as toothpaste, liquid dentifrice, liquid dentifrice, gel dentifrice, mouthwash, coating agent, mouthwash, It can be prepared as an oral composition such as a dental pasta or a denture cleaner, and has a titanium binding amount of Ti.
O ₂ as to SiO ₂ 0.5 to 15 wt%, preferably in the range of 1.0 to 10 wt%, and the free alkali metal (M) as M / SiO ₂ from 3.0 to 12.0 It is based on a synthetic amorphous titanium-bonded silicate containing mol / mol%, preferably 3.5 to 8 mol / mol%, and combined with an enzyme.

Here, the above-mentioned synthetic amorphous titanium-bonded silicate will be described in detail. The silicate contains titanium in the above-mentioned bond amount, and the titanium bond amount is Ti.
When O ₂ is less than 0.5% by weight based on SiO _2, the properties of the synthetic amorphous titanium-bonded silicate are not substantially exhibited in terms of cleaning power and the like. Further, when the amount of titanium binding is large, it is difficult to control the physical properties thereof, which is not preferable for use in an oral composition. In addition, sodium is preferable as the alkali metal.

The above-mentioned titanium-bonded silicate has an average primary particle diameter of 0.01 to 0.50 μm, a secondary average particle diameter of the aggregate of 3 to 25 μm, and a specific surface area by BET method of 20 μm. preferably ~200m is ² / g, BET specific surface area is decreased 20 m ² / g is less than a hiding power, there is a case where compatibility with the fluorine exceeds 200 meters ² / g is deteriorated.

The titanium-bonded silicate is, for example, S
iO_Two/ X_TwoO (X: alkali metal) water in the range of 2 to 4
Soluble alkali metal silicate and titanium chloride, oxysalt
Water such as titanium iodide, titanium sulfate, titanium nitrate
Soluble titanium salt and mineral acid such as hydrochloric acid and sulfuric acid
By reacting them. This place
Water-soluble titanium salt to the mineral acid to add titanium
Mineral acids, which are combined with aqueous alkali metal silicate solutions
Reaction allows titanium to be uniformly bonded in silica
Is preferred. In addition, the above reaction
Starting from the Lucari side, nucleation is performed on the alkali side, and the reaction
It is recommended to do so that the end pH is between 6 and 9.
Here, the free alkali metal is mainly a water-soluble alkali.
Derived from metal silicate, but SiO_TwoIncluding
Adjustment of the amount is mainly adjusted by the pH at the end of the reaction. water
Incompatible with alkali metals derived from soluble alkali metal silicates
When adding, a water-soluble alkali metal salt is separately added. This
The water-soluble alkali metal used for this is sodium,
Potassium and lithium hydroxides, carbonates and bicarbonates are preferred.
As an example, the free alkali in silicate
The main factor controlling the metal content is the end pH as described above.
You. The reaction temperature is preferably 50 to 100 ° C.

The amount of the synthetic amorphous titanium-bonded silicate in the oral composition is not necessarily limited, but is usually 1 to 50% by weight, especially 5 to 40% by weight of the whole composition.

On the other hand, enzymes to be incorporated into the oral composition of the present invention include dextranase, mutanase, amylase, lysozyme, protease, lytic enzyme and the like.
Antibodies and the like can also be blended, and one of these can be used alone or in combination of two or more.

Here, dextranase obtained from a known dextranase-producing bacterium belonging to the genus Ketomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, or Servibrio by a known method is used. Of course, dextranase produced by other microorganisms can also be used. The amount of dextranase is usually 0.05 to 20,000 units, preferably 0.5 to 500 units, per 1 g of the oral composition.

The mutanase is, for example, Pseudomonas sp., Trichoderma harzianum, Streptomyces verensis, Aspergillus needans, Flavobacterium sp., Bacillus sp.
Not only mutanase obtained by a known method from a known mutanase-producing bacterium such as SP, but also a mutanase produced by another microorganism can be used. The compounding amount is usually 10 to 10,000 per gram of the oral composition.
00 units, and more preferably 20 to 5,000 units.

[0015] The amount of other enzymes can be selected as appropriate.
A plaque formation inhibitory effect amount can be added.

The oral composition of the present invention can contain other additives as optional components in addition to the above essential components, depending on the dosage form.

In the case of dentifrices, for example, abrasives, thickeners,
Binders, surfactants, sweeteners, preservatives, active ingredients, pigments, flavors and the like can be blended, and these components can be mixed with water to produce.

As the abrasive, in addition to the base of the present invention (the above-mentioned titanium-bonded silicate), it is possible to use in combination with one or more of the following. Silica-based abrasives such as sedimentable silica, ignitable silica, aluminosilicate, and zirconosilicate; dicalcium phosphate dihydrate;
Calcium phosphate anhydrate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate,
Insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tribasic calcium phosphate, hydroxyapatite, fluoroapatite, calcium-deficient apatite, tribasic calcium phosphate, quaternary calcium phosphate, Octacalcium phosphate,
A synthetic resin-based abrasive is exemplified.

As the thickener, one or more of glycerin, sorbitol, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6,000, polyhydric alcohols such as reduced starch saccharified products, and the like can be used.

Examples of the binder include xanthan gum, sodium alginate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, carbopol, guar gum, gelatin, Avicel, and inorganic binders such as montmorillonite, kaolin and bentonite. Agents and the like.

Examples of the surfactant include an anionic surfactant, a cationic surfactant, and a nonionic surfactant. Specific examples thereof include sodium lauryl sulfate, sodium N-lauroyl taurine, N-acyl sarcosinate, and α-olefin sulfone. Acid sodium, N-acyl glutamate, 2-
Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-acyl taurate,
Examples include sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, decaglyceryl laurate and the like.

As sweeteners, sodium saccharin,
As preservatives such as aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartin,
Examples thereof include parabens such as butylparaben and ethylparaben, paraoxybenzoate, sodium benzoate and the like.

Various active ingredients include fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride and sodium monofluorophosphate, and water-soluble compounds such as potassium and sodium phosphates of orthophosphoric acid. Phosphate compounds, allantochlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and salts thereof, sodium chloride, tranexamic acid, epsilon aminocaproic acid, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, isopropylmethylphenol, chlorhexidine Salts, triclosan, biosol, cetylpyridinium chloride, azulene, glycyrrhetin, glycyrrhetinic acid,
Copper chlorophyllin sodium, chlorophyll, chelating phosphate compounds such as glycerophosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and derivatives thereof, sodium tripolyphosphate, zeolite,
Methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, benzethonium chloride, sodium chloride, dihydrocholesterol,
Extracts such as trichlorocarbanilide, zinc citrate, soft corn extract, oak extract, chamomile, clove, rosemary, ogre, safflower and the like are included.

Examples of the flavor include 1-menthol, carvone, anethole, cineol, methyl salicylate, limonene, ethyl butyrate, eugenol, thymol,
Perfume ingredients such as cinamic aldehyde or derivatives thereof,
Essential oil components such as peppermint and spearmint are exemplified,
Examples of the colorant include Blue No. 1, Yellow No. 4, Green No. 3, and the like. In addition, the compounding amount of these components can be made into a usual amount as long as the effect of the present invention is not hindered.

[0025]

The oral composition of the present invention has a high cleaning power, and is excellent in the effect of inhibiting plaque formation and its durability.

[0026]

EXAMPLES Hereinafter, the present invention will be described specifically with reference to experimental examples and examples, but the present invention is not limited to the following examples. In addition,% shows weight% unless there is particular notice.

EXPERIMENTAL EXAMPLE Sobrinus 671
5 was cultured in a gradient medium, and plaque was allowed to adhere to the test tube wall. Next, the plaque was treated with the dentifrice composition shown in Table 1 (treatment time: 1, 3, 5, 10 minutes). After the treatment, the amount of plaque remaining on the tube wall was measured as turbidity. Turbidity is O
It was measured at D550 nm and the plaque suppression rate was determined by the following equation. Table 2 shows the results.

[0028]

(Equation 1)

[0029]

[Table 1] Abrasive A: Synthetic amorphous titanium-bound silicate Na / SiO ₂ 5.5 mol% TiO ₂ 5 wt% binding to SiO ₂ , average particle size 1
2 μm Abrasive B: anhydrous silicate Na / SiO ₂ 1.0 mol%, average particle size 12 μm

[0030]

[Table 2]

From the results shown in Table 2, it is confirmed that the activity of the enzyme is maintained by using the enzyme together with the synthetic amorphous titanium-bonded silicate according to the present invention.

Examples will be described below. In the following examples, the base (No. 1) is a synthetic amorphous titanium-bonded silicate having a binding amount of TiO ₂ to SiO ₂ of 1%, and the base (No. 2) has the same binding amount. 5% of synthetic amorphous titanium-bound silicate and base material (No. 3) have the same amount of 1
5% synthetic amorphous titanium-bound silicate. Incidentally, Na is used as a free alkali metal in these silicates.
The metal contains 5.4 mol% of Na in Na / SiO ₂ .

[Example 1] Toothpaste base (No. 1) 15% sorbitol 30 sodium saccharin 0.2 sodium alginate 0.6 xanthan gum 0.6 propylene glycol 5.0 lauric diethanolamide 1.6 mutanase 15u / g dentifrice Sodium Lauryl Sulfate 0.8 Gelatin 0.2 Fragrance 1.0 0.1% Blue No. 1 0.8 Water Total Balance 100.0%

[Example 2] Toothpaste base (No. 2) 15% sorbitol 25 sodium saccharin 0.2 CMC 1.2 propylene glycol 5.0 sodium monofluorophosphate 0.5 sodium lauryl sulfate 1.5 chlorhexidine hydrochloride 0 0.2 dextranase 35u / g dentifrice perfume 1.0 paraben 0.1 water balance 100.0%

Example 3 Toothpaste Base (No. 2) 15% Silicic Anhydride 5 Sorbit 20 Sodium Saccharin 0.2 CMC 1.2 Propylene Glycol 4.0 Lauroyl Sarcosine Sodium 0.3 Sodium Lauryl Sulfate 1.0 Mutanase 500u / g toothpaste fragrance 1.3 water balance total 100.0%

Example 4 Toothpaste Base (No. 2) 15% Silicic Anhydride 3 Sorvite 25 Saccharin Sodium 0.2 CMC 1.5 Propylene Glycol 4.0 Sodium Lauryl Sulfate 1.0 Sodium Fluoride 0.2 Mutanase 300u / g toothpaste tranexamic acid 0.05 perfume 1.5 water balance 100.0%

Example 5 Toothpaste Base (No. 2) 10% Hydroxyapatite 3 Sorvite 25 Saccharin Sodium 0.2 CMC 1.7 Propylene Glycol 4.0 Mutanase 300 u / g Toothpaste Sodium Fluoride 0.2 Sodium Lauryl Sulfate 1.2 Dipotassium glycyrrhizinate 0.05 Perfume 1.0 Water Total balance 100.0%

Example 6 Toothpaste Base (No. 2) 20% Alumina 0.5 Glycerin 20 Sodium Saccharin 0.1 Carrageenan 1.0 Sodium Alginate 0.5 Mutanase 1,000 u / g Toothpaste Propylene Glycol 4.0 Lauryl Sodium sulfate 1.0 Sodium monofluorophosphate 0.7 Fragrance 1.0 Water Total balance 100.0%

Example 7 Toothpaste Base (No. 1) 25% Sorbite 30 Sodium Lauryl Sulfate 1.2 CMC 1.2 Propylene Glycol 3.0 Saccharin Sodium 0.2 Alumina 1.0 Dextranase 500 u / g Toothpaste Vitamin E 0.5 Glycyrrhetinic acid 0.05 Tranexamic acid 0.05 Butylparaben 0.01 Fragrance 1.0 Water Total balance 100.0%

Example 8 Toothpaste Base (No. 1) 40% Sorbit 20 Sodium Lauryl Sulfate 2.0 CMC 1.1 Sodium Saccharin 0.02 Silicic Anhydride 3.0 Augon Dry Extract 0.001 Dextranase 200u / G Toothpaste Sodium fluoride 0.2 Sodium chloride 10 Fragrance 1.1 Water Total balance 100.0%

Example 9 Toothpaste Base (No. 3) 10% Carrageenan 0.5 HEC 0.5 Sorbit 20 Sodium Lauryl Sulfate 1.5 Sodium Saccharin 0.1 Propylene Glycol 5.0 Aluminum Lactate 2.0 Triclosan 0 0.3 Sodium monofluorophosphate 0.4 Dextranase 50u / g Toothpaste Mutanase 200u / g Toothpaste Fragrance 1.3 Total water balance 100.0%

Example 10 Toothpaste Base (No. 1) 15% Silica Gel 5 Sorbite 40 Glycerin 18 Sodium Lauryl Sulfate 1.0 Sodium Alginate 0.3 Xanthan Gum 0.2 Saccharin Sodium 0.1 Propylene Glycol 2.0 Glycyrrhizic Acid Dipotassium 0.05 Dextranase 20u / g Toothpaste Sodium fluoride 0.2 Decaglyceryl laurate 0.5 0.1% Blue No. 1 0.8 Fragrance 1.3 Water Total balance 100.0%

[Example 11] Liquid dentifrice base (No. 2) 15% sorbitol 50 glycerin 18 sodium lauryl sulfate 1.0 xanthan gum 0.5 saccharin sodium 0.1 lauric acid diethanolamide 1.0 propylene glycol 2.0 triclosan 0.3 Dextranase 20u / g Toothpaste 0.1% Green No. 3 0.8 Fragrance 1.3 Water Balance 100.0%

[Example 12] Liquid dentifrice base (No. 3) 15% sorbitol 50 glycerin 20 sodium lauryl sulfate 1.2 sodium alginate 0.3 xanthan gum 0.2 sodium saccharin 0.1 anhydrous sodium sulfate 0.3 propylene glycol 2.0 Dextranase 50u / g Toothpaste Triclosan 0.02 Sodium monofluorophosphate 0.5 Decaglyceryl laurate 0.5 0.1% Blue No. 1 0.8 Fragrance 1.3 Water Total balance 100.0%

Example 13 Mouthwash Base (No. 1) 1% Denatured ethanol 18 Polyoxyethylene hydrogenated castor oil 2.0 Glycerin 10 Citric acid 0.01 Trisodium citrate 0.3 0.1% Green No. 201 0.8 Dextranase 100u / g Toothpaste Spice 0.5 Water Balance 100.0%

[Example 14] Mouthwash base (No. 3) 0.5% 90% ethanol 18 polyoxyethylene (80) sorbitan monotaurate 2.0 cetylpyridinium chloride 0.1 sodium monofluorophosphate 0 .1 Triclosan 0.02 Dextranase 80u / g Mouthwash 0.1% Yellow No.4 1.0 Fragrance 1.2 Water Balance 100.0%

Example 15 Dental Pasta Base (No. 2) 5.0% Hydroxyethylcellulose 3.0 Carrageenan 2.0 Sorbit 40 Sucrose Palmitate Monoester 2.0 Saccharin Sodium 0.1 Aluminum Lactate 0 Dextranase 500u / g Dental pasta Dipotassium glycyrrhizinate 0.05 Fragrance 0.5 Water Total balance 100.0%

Claims (1)

[Claims] 1. A Si titanium bond content as TiO ₂
O ₂ to a 0.5 to 15 wt%, and the free alkali metal (M) containing 3.0 to 12.0 mol / mol% as M / SiO ₂ synthetic amorphous titanium coupling silicate, An oral composition characterized by being combined with an enzyme.