JPH1133114A - Drug solution injecting apparatus - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable to dissolve and blend in a short time preventing contamination and to improve flexibility of use by air tightly covering the base end opening part of a drug solution injecting vessel main body with a gasket at a prescribed position inside and whose inside pressure can be reduced. SOLUTION: This drug solution injecting apparatus is constituted of a vessel main body 2 comprising a gas barrier material, a gasket main body 3 liquidtightly sliding therein, a plunger 4 thereof, a cap 5, a seal material 6, a desiccant 91, a deoxygenizer 92, etc. Spaces 25, 26 are kept at a reduced pressure condition. A vessel cap 5 is constituted of a sealing member with a cap main body 51 and a female screw 52, the female screw 52 is detachably and airtightly screwed with a male screw 22 at the vessel main body opening part 21. It is also preferable to form a gas barrier layer on the surface of the sealing member 53 to improve gas barrier performance. Thus, drug solution can be dissolved and blended preventing contamination.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid medicine injection device, and more particularly to a liquid medicine injection device used for dissolving and compounding powdered drugs.

[0002]

2. Description of the Related Art Powdered drugs such as antibiotics are dissolved in a dissolving solution and blended as necessary.
To mix such a drug, first, a puncture needle of a syringe (syringe) is pierced into the elastic stopper of the lysis solution bag, the plunger is pulled, and the lysis solution in the lysis solution bag is collected in the syringe. The needle is pierced into the elastic stopper of the container (vial) containing the drug, the collected solution is transferred, the drug is dissolved in the vial, mixed, and then the drug is again mixed with the syringe, and the mixed solution is sucked and collected by the syringe. Then, the puncture needle of the syringe is pierced again through the elastic stopper of the solution bag, and the plunger is pushed to inject the drug mixture into the solution bag. However, the compounding of such a chemical solution requires a complicated operation procedure, takes a long time for the compounding,
There is a drawback that foreign matter is easily contaminated and bacteria are easily contaminated. Recently, in order to simplify this operation, a kit product that separately stores a drug and a dissolving solution in a multi-chamber container formed with a chamber partitioned by a weak seal portion, and peels off the weak seal portion during use to mix. It has been developed (JP-A-4-364851). The operation of these kits is simple, but there is a problem that the method of use and application are limited due to restrictions such as the amount of the lysis solution cannot be changed on site.

[0003]

SUMMARY OF THE INVENTION An object of the present invention is to dissolve and mix drugs by a simple operation without causing contamination.
An object of the present invention is to provide a highly versatile drug solution infusion device that can be performed in a short time and is not limited in administration method and the like.

[0004]

This and other objects are achieved by the present invention which is defined below as (1) to (8). (1) A cylindrical container main body having a distal end closing part and a base end opening part, a cap provided at the distal end of the container main body and hermetically closing an opening for communicating the inside and outside of the container main body, and a liquid inside the container main body. In a drug solution injector having a gasket that slides tightly and containing a medicine in a space defined by a container body, a cap, and a gasket, the base opening is hermetically covered with an airtight maintenance member, A gas injector in which a gasket is arranged at a predetermined position in a container body and the inside of the container body is depressurized. (2) The chemical injection device according to (1), wherein the gasket is detachably joined to the airtight maintenance member. (3) The base end of the gasket is a positioning part (1), (7), (8) or (9) for preventing the gasket from moving toward the syringe base end when the space returns to normal pressure. The drug solution injector according to (1). (4) The liquid injector according to (3), further including a plunger mounting portion at a base end of the positioning portion. (5) The liquid injector according to (4), wherein the airtight maintenance member can be pierced by a plunger. (6) Any of (1) to (5), (7), (8) and (9), in which a deoxygenating agent and / or a desiccant is stored in a space on the base end side of the gasket inside the container body. The drug solution injection device according to any one of the above.

(7) A cylindrical container main body having a distal end closing portion and a base end opening portion, a cap provided at the distal end of the container main body and hermetically closing an opening for communicating the inside and outside of the container main body, and a container main body In a drug solution injection device having a gasket that slides inside in a liquid-tight manner and containing a medicine in a space defined by a container body, a cap, and a gasket, the base end opening is air-tightly and peelably covered. A chemical injection device having an airtight film, a base end of a gasket is detachably joined to the airtight film, and the inside of the container body is depressurized. (8) A cylindrical container main body having a distal end closing part and a base end opening part, a cap provided at the distal end of the container main body and hermetically closing an opening for communicating the inside and outside of the container main body, and a liquid inside the container main body. In a chemical liquid injector having a gasket that slides tightly and containing a medicine in a space defined by a container body, a cap, and a gasket, an annular airtight maintenance member that airtightly covers the base opening is provided. A chemical injection device, wherein a base end of a gasket is detachably joined to the airtight maintenance member, and the inside of the container body is depressurized. (9) The liquid injector according to (8), wherein a plunger mounting portion is provided at a base end of the gasket, and the plunger mounting portion is exposed through an annular cutout of the airtight maintenance member.

[0006]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a liquid injector according to the present invention. FIG.
As shown in FIG. 1, the chemical liquid injector 1 of the present invention mainly comprises a container body 2, a gasket body 3 which can slide in a liquid-tight manner along the inner peripheral surface of the container body 2, and a gasket body. A detachable plunger 4 that is operated and operated, a cap 5 as sealing means, a sealing material 6, a positioning member 7 that constitutes a gasket together with the gasket main body, and a desiccant 91 that can be inserted as needed. And an oxygen scavenger 92. Hereinafter, these components will be sequentially described. The container main body 2 is formed of a bottomed cylindrical body having a closed top end to form a bottom portion, and an opening portion 21 functioning as a discharge port for a chemical solution protruding from the front end, and has a predetermined rigidity. It is made of a rigid material. As a constituent material of the container body 2, for example, polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly-4 (4-methylpentene-1), acrylic resin, polyacrylonitrile, acrylonitrile-butadiene-styrene copolymer Coalescence, polyethylene terephthalate, polybutylene terephthalate, polyethylene naphthalate, polyethylene naphthalate
Various resins such as polyesters such as polyethylene terephthalate copolymers, polyvinylidene fluoride, butadiene-styrene copolymers, cyclic polyolefins, and mixed resins thereof are exemplified.

In order to maintain the reduced pressure in the spaces 25 and 26 in the container main body 2, the constituent material of the container main body 2 preferably has a gas barrier property (gas impermeable). Since this gas barrier property is high, the constituent material of the container body 2 is:
Polyethylene terephthalate, polyacrylonitrile,
Polyvinylidene fluoride, polyethylene naphthalate, and polyethylene naphthalate-polyethylene terephthalate copolymer are preferred. Further, when formed of a material having a low gas barrier property, the surface of the container body 2 (for example, the outer surface)
Is preferably coated with a film having gas barrier properties such as polyvinyl alcohol and ethylene-vinyl alcohol copolymer. When a light-unstable drug is encapsulated, it is preferable to cover with a light-impermeable film. Even in that case, it is preferable that the constituent material of the container main body 2 is substantially transparent or translucent in order to secure the visibility of the inside. That is, visibility is ensured by adding a coating containing a substance that absorbs a specific wavelength to selectively pass a wavelength in the visible region that does not affect the medicine, or by adding the substance to a constituent material of the container body. Is preferred. In order to further improve the gas barrier properties, the container body 2
A gas barrier layer can be formed on the surface of the substrate by, for example, vapor deposition or sputtering. Examples of the composition of the gas barrier layer include oxides such as silicon oxide, aluminum oxide, and titanium oxide. Further, the container body 2 may be made of a metal material such as stainless steel, titanium, and aluminum, or a ceramic material such as glass and alumina, in addition to the above-described materials.

A flange 23 is provided on the outer periphery of the base end of the container body 2.
Are formed. A peripheral protruding edge 24 extending from the container body is formed at the base end of the container body. Ridge 24
It is preferable that the tip is flat so that the sealing material 6 can be easily joined. The mouth portion 21 is formed of a cylindrical body having a tapered portion having an outer diameter tapering toward the distal end at least, and a male screw 22 is formed on the outer peripheral surface on the base end side. The space in the mouth 21 communicates with the space 25 in the container body 2. In the container body 2, the container body 2
A gasket main body 3 that can slide in a liquid-tight manner along the inner peripheral surface of the gasket is inserted. The gasket main body 3 is a substantially columnar member made of an elastic material. Specific examples of the constituent material of the gasket body 3 include styrene-based elastomers, hydrogenated styrene-based elastomers, and polyolefins such as polyethylene, polypropylene, polybutene, α-olefin copolymer, liquid paraffin, and process oil. Examples thereof include those in which powdered inorganic substances such as oil, talc, cast, and mica are mixed. Furthermore, polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer,
Various rubber materials (especially vulcanized) such as polyurethane elastomer, natural rubber, isoprene rubber, butyl rubber, chloroprene rubber, nitrile-butadiene rubber, styrene-butadiene rubber, and silicone rubber, and mixtures thereof are exemplified. Preferably, a gas-permeable material is desirable so that gas can move between the spaces 25 and 26 in the container body 2.

The gasket main body 3 is not limited to the whole made of the above-mentioned elastic material, but may be any as long as at least a portion in liquid-tight contact with the inner surface of the container body is made of the above-mentioned elastic material. Good. On the outer peripheral surface of the gasket main body 3, a ring-shaped projection 31 is formed over the entire circumference. The protrusion 31 is in close contact with the inner peripheral surface of the container main body 2, and maintains liquid tightness when the gasket main body 3 slides on the container main body 2. In addition, the projection 31 also has a function of imparting an appropriate slidability of the gasket main body 3 necessary for pushing out the internal solution. In order to maintain good liquid tightness of the gasket main body 3 with respect to the container main body 2, the maximum outer diameter of the gasket main body 3, that is, the ring-shaped protrusion 31
Is preferably slightly larger than the inner diameter of the container body 2. Further, in order to further improve the liquid tightness and the slidability, a plurality of protrusions 31 are provided at predetermined intervals along the longitudinal direction of the container body 2 (3 in this embodiment), as shown in the figure.
Are preferably formed. In order to enable connection with the positioning member 7, a so-called umbrella-shaped concave portion 3 having an enlarged tip is provided at a central portion inside the gasket main body 3.
2 are formed. The distal end of the positioning member 7 is connected to such a gasket main body 3. That is,
The positioning member 7 has an umbrella-shaped head portion 72 formed on the distal end side thereof.
And is engaged with the gasket main body 3.

On the base end side of the positioning member 7, a concave portion 73 for connecting the distal end portion 41 of the plunger 4 is formed. The concave portion 73 may have any shape as long as the distal end portion 41 of the plunger 4 can be connected. In the example shown in FIG. 1, the concave portion 73 has a guide surface 74 that is tapered toward the base end portion. 4 can be easily connected to the tip 41. Although not shown, the concave portion 73
A female screw is formed therein, and a male screw that is screwed to the tip portion 41 of the plunger 4 is formed. If the female screw and the male screw are screwed, the connection can be made stronger and the operation can be performed more safely. Also,
At the base end of the plunger 4, a handle portion 44 for gripping and operating the plunger 4 by hand is formed. The base end surface 75 of the positioning member 7 is joined to the seal member 6 by setting conditions so that the base member 75 can be peeled off by using known means such as adhesion and fusion, and the seal member 6 is further bonded to the base end surface of the container body 2. Similarly, the gasket main body 3 can be positioned at a predetermined position and moored. In this way, the gasket can be easily positioned at the time of manufacture, and the gasket can be reliably prevented from moving in the container body even during storage or the like. 6 does not necessarily have to be joined. In order to meet these purposes, the sealing members can be anchored so that they do not peel off before use, and when the gasket is pressed with a plunger or the like, the gasket comes off the sealing material and the liquid injection operation is performed. It is preferable to make settings so that In the present embodiment, it is preferable to set the latter so that the airtightness in the container body can be maintained during storage, and that it can be easily peeled off by using a tongue piece 61 described later during use.

Regarding the material of the sealing material 6, it has a high gas barrier property and can be easily joined (adhered, fused, etc.).
Any material can be used as long as it can be easily peeled or penetrated by the tip of the plunger 4. Specifically, metal foil such as aluminum foil, ethylene-vinyl alcohol copolymer, polyvinylidene chloride, polyethylene terephthalate, or other materials And a laminated film with the above material.
Preferably, as described in JP-A-5-45262, a laminated film in which a resin thin film is provided on the container body 2 side, for example, a container, in order to make it easier for the gas barrier film constituting the sealing material to be joined to the container body 2 When the main body 2 is made of polyethylene terephthalate, a laminated film of aluminum foil and stretched polyethylene terephthalate can be used. Note that a tongue piece 61 for starting peeling is provided when it becomes necessary to peel off the sealing material 6 in the subsequent operations.

A mouth 21 is provided at the tip end of the container body 2.
(Sealing means) 5 that hermetically seals is provided. The cap 5 includes a cap body 51 detachably mounted (screwed) around the mouth 21, and a sealing member 53 installed inside the cap body 51. On the inner peripheral surface of the base end portion of the cap body 51, a female screw 52 screwed with the male screw 22 is formed.
By screwing the male screw 22 and the male screw 22, the cap main body 51 is mounted around the mouth 21. The sealing member 53 is formed of a membrane or a plug made of an elastic body such as various rubbers or thermoplastic elastomers as described above, and can be penetrated by a second needle tube 832 described later, and is itself airtight. It has the property. Further, in order to improve gas barrier properties, a gas barrier layer (not shown) as described above can be formed on the surface of the sealing member 53. When the cap body 51 is screwed into the mouth 21 and attached, the mouth 2
The tip end surface of the space 1 is tightly adhered (pressed) to the sealing member 53, whereby the opening 21 is hermetically sealed, and the reduced pressure of the spaces 25 and 26 can be maintained in cooperation with the sealing material 6. it can.
A tapered guide surface 54 whose inner diameter gradually increases toward the distal end is formed on the distal end side of the sealing member 53 of the cap body 51. The guide surface 54 has a role of guiding the needle point 834 of the second needle tube 832 to the center of the sealing member 53 when the sealing member 53 is pierced by a second needle tube 832 shown in FIG. Fulfill.

The spaces 25, 2 in the container body 2 surrounded by the container body 2, the sealing member 7, and the sealing member 53 as described above.
Reference numeral 6 denotes a reduced pressure state. In this case, the space 25, 2
The pressure of 6 is preferably about 40 to 600 torr, and 70 to
About 200 torr is more preferable. If the pressure in the space 25 is too low, when the inflow of the liquid into the space 25 is completed, the proportion of the liquid in the space 25 increases (the number of air bubbles decreases), and by shaking the container body 2, Solubility and agitation during dissolution decrease, and if the pressure in the space 25 is too high, the amount of liquid flowing into the space 25 decreases. For the same reason, the amount of the liquid flowing in is preferably 70 to 90% of the space 25. Also,
Although not shown, a medicine, particularly a solid (for example, a powder, a granule, a lump, or a gel) may be contained in the space 25 as necessary.
Are stored. The type of drug is not particularly limited, for example, antibiotics, vitamins (multivitamins), various amino acids, antithrombotics such as heparin, insulin, antitumor agents, analgesics, inotropics, intravenous anesthetics, Any anti-parkinson agent, ulcer treatment agent, corticosteroid agent, arrhythmia agent, correcting electrolyte, antiviral agent, immunostimulant, etc. may be used. The form of the drug is not limited to a solid, but may be a liquid. Further, two or more drugs may be mixed.

Further, a desiccant 91 and a deoxidizer 92 can be accommodated in the space 26 as required. Thereby, it is possible to store a temporally unstable drug having hygroscopicity or oxidizing property among the above-mentioned drugs. As the desiccant 91 inserted into the space 26, for example,
Examples include those containing silica gel, zeolite, and the like as components. Examples of the oxygen scavenger 92 include Ageless (manufactured by Mitsubishi Gas Chemical Company), and those using amorphous copper. The desiccant 91 and the oxygen absorber 92 form the space 2
One or both are inserted depending on the degree of hygroscopicity and oxidizability of the medicine stored in 5. The desiccant 91 and the oxygen absorber 92 may be inserted only into the space 26, but may be bonded or embedded in the positioning member 7, or may be bonded or embedded in the base end surface of the gasket main body 3,
It may be bonded to the sealing material 6 (not shown). Further, since the space 26 is a ring-shaped space, it is preferable to use a ring-shaped desiccant 91 and an oxygen scavenger 92. At this time, when both the desiccant 91 and the oxygen scavenger 92 are inserted, a semi-ring shape may be used. Space 25,
26 is in a reduced pressure state, the amount of remaining moisture and oxygen is small, and a desiccant 91 and a deoxidizer 92 to be used are used.
Is small enough to absorb water. Also desiccant 9
1 and the oxygen absorber 92, the space 2
The pressure at 5, 26 changes, but does not cause a large change in water absorption. At this time, the pressure can be controlled by using a carbon dioxide releasing type oxygen scavenger.

Next, the configuration of the holder 8 used by being attached to the drug solution injector 1 will be described. Holder 8
It has a cylindrical holder body 81 whose base end is open.
The holder body 81 has a shape and dimensions that allow the cap 5 to be inserted and fitted from the base end opening. A through hole is provided at the tip of the holder body 81, and a female screw (not shown) is formed on the inner peripheral surface of the through hole. Then, as described later, the double-ended needle 83 is attached to the female screw via an intermediate male screw. The double-ended needle 83 is a first needle tube 83
The first and second needle tubes 832 are connected to their needle tips 833, 83.
4 are fixed to the hub 84 so that they face in opposite directions, and their lumens communicate with each other. The first needle tube 831 and the second needle tube 832 are in liquid communication with each other and open at their respective needle points, and are made of, for example, various metal materials such as stainless steel, titanium, and aluminum. Further, it may be made of various ceramic materials such as glass and alumina, or various hard resins such as polyester, polyphenylene sulfide, and polycarbonate. A male screw (not shown) is formed on the outer peripheral portion of the hub 84. The male screw is screwed into the female screw so that the double-ended needle 83 is attached to the holder body 81.
Attached to A covering member 87 that covers at least the needle tip 834 is provided around the second needle tube 832. When the envelope member 87 is not in use, the second needle tube 83
A function of preventing contamination of the second and the like and maintaining a sterile state;
And a function of preventing liquid leakage from

The enclosing member 87 is preferably formed of a film made of an elastic material as described above, and can be easily penetrated by the needle point 834. The distal end portion of the enclosing member 87 forms a cylindrical body and coaxially covers the second needle tube 832, and the distal end is fixed to the base end of the hub 84 in a liquid-tight manner. The base end of the enclosing member 87 forms a hemispherical closed end that is continuous from the distal end side. In addition, the following form can also be taken as another aspect of the drug | chemicals feeder of this invention. As shown in FIG. 3, compared to the example of FIG.
That is, the center of the sealing material 6 constituting the airtight maintenance member is cut out, the positioning member 7 is exposed, and the sealing member 6 is joined to the protruding edge 24 of the container body 2 and the base end portion 75 of the positioning member 7, thereby providing airtightness. The point is that they are different. In this case, in order to maintain the reduced pressure state of the spaces 25 and 26,
It is preferable to use a material having high gas barrier properties for the positioning member 7. It is more preferable to use the same material as the container body 2 for joining with the sealing material 6. In this case, since the concave portion 73 of the positioning member 7 is in an exposed state, the plunger 4 can be connected without peeling the sealing material 6. Further, the base portion 75 and the sealing material 6
Is weaker than the sealing strength between the projection 24 and the sealing material 6, the plunger 4 is pressed in the distal direction, and when the plunger 4 is pressed, the base end portion 75 is separated from the sealing material 6 and the gasket body 3 is moved in the distal direction. , And the chemical solution can be discharged. Thereby, the operation of peeling off the sealing material 6 can be omitted, and the operation can be further simplified.

Further, the cap and the holder of the present invention can be formed in the following shapes. Cap body 5
As shown in FIG. 2, on the outer peripheral surface of the vertical groove 1, a T-shaped groove 55 composed of a vertical groove 552 linearly extending from the tip to a predetermined position and a branch groove 551 branched in the middle of the vertical groove. Is formed. The holder body 8 shown in FIG.
The protrusion 811 provided on the inner peripheral surface of the first member 1 can be moved. In the storage state, the projection 811 is in the form of the branch groove 551.
Has stopped within. When introducing the solution into the container body 2, first, the first needle tube 831 of the holder 8 is pierced through the co-infusion port of the solution container (not shown). Next, the container body 2 is placed on the holder 8, and the protrusion 811 is formed in the vertical groove 552 of the groove 55.
Rotate in the direction to move to the position. When the projection 811 comes to the position of the vertical groove 552, the projection 811 is moved until it reaches the position of the lower end 553 of the vertical groove 552 by pressing the container body 2 toward the solution container. At this time, the needle point 834 of the second needle tube 832 pierces the sealing member 53 of the cap 5, and the space 25 in the container body 2 and the solution container are
The solution flows into the space 25 under reduced pressure, and the flow of the solution ends when the space 25 becomes equal to the outside pressure. The number of the grooves 55 may be any number, but preferably one or two. And the protrusion 811 is formed in the groove 5.
It suffices if the number and position correspond to 5. Further, the groove 55 may be formed on the inner peripheral surface of the holder 8. In this case, the corresponding projection 811 may be formed on the outer peripheral surface of the cap 5. By forming the grooves 55 and the projections 811, the holder 8 can be kept attached to the container body 2 during storage, and the solution can be reliably introduced into the container body 2 during use.

Next, an example of a method of using the drug solution injector 1 will be described. [1] An unused chemical liquid injector 1 shown in FIG. 1 is prepared. The space 25 maintains a predetermined decompressed state, and a predetermined amount of a solid drug such as a powder is stored in the space 25. In this state, the gasket main body 3 and the positioning member 7 are joined to the sealing material 6 and maintain the state stopped at the base end side of the container main body 2. [2] On the other hand, a container containing a liquid to be mixed with a drug is prepared. In the present embodiment, an infusion bag (not shown) in which a dissolving solution is put will be described as an example. Mixed injection port of infusion bag (consisting of a stopper made of elastic material)
The first needle tube 831 of the double-ended needle 83 of the holder 8 in FIG.
After that, the cap 5 of the drug solution injector 1 is inserted into the holder main body 81. Thereby, the second needle tube 832
Penetrates the sealing member 53, and the needle tip 834 of the container body 2
Of the mouth 21. The encapsulating member 87 has its distal end pierced through the second needle tube 832 and is pressed by the sealing member 53 and the guide surface 54 so as to be bent toward the distal end side and folded in a bellows shape. Then, the needle tip 834 of the needle tube 831 is guided by the guide surface 54 and the sealing member 53
And the sealing member 53 can be reliably penetrated at an appropriate position. At this time, the gasket body 3
By the positioning member 7, the movement of the space 25 in the direction of the space 26 due to the positive pressure of the space 25 is suppressed.

As described above, the inside of the infusion bag and the space 2
5 communicates via the double-ended needle 83, since the space 25 is in a depressurized state, the lysis solution in the infusion bag passes through the lumens of the first needle tube 831 and the second needle tube 832 in the space 25. Flows into. [3] When the flow of the solution into the space 25 stops, the chemical liquid injector 1 is rocked and vibrated as necessary to
Dissolves the drug stored inside. Thereby, a desired chemical solution 10 to be blended is adjusted. [4] Next, the sealing material 6 bonded to the protrusion 24 at the base end of the container body 2 and the base end surface 75 of the positioning member 7 is peeled off.
The plunger 4 is fitted into the exposed concave portion 73 of the positioning member 7. [5] Subsequently, the plunger 4 is pressed in the distal direction, and the gasket main body 3 is slid in the same direction. Thereby, the space 2
The drug solution 10 in 5 is sequentially injected into the infusion bag through the lumens of the mouth 21, the second needle tube 832, and the first needle tube 831, and is compounded. [6] As described above, when the injection of the drug solution into the infusion bag is completed, the holder 8 is removed from the cap 5. Along with this, the second needle tube 832 is pulled out of the sealing member 53. At this time, the envelope member 8 folded in a bellows shape
Due to the elastic force of the needle 7, the shape is instantaneously restored to the original shape and the second needle tube 832 is encapsulated again, so that the liquid is prevented from leaking from the needle tip 834 and scattered around. And the aseptic condition of the solution in the infusion bag is maintained by the action of resealing of the enclosing member 87 and the mixed injection port.

When it is desired to continuously dissolve and inject another drug, the above-described operation is repeated for another drug solution injection device while the holder 8 is pierced through the co-infusion port of the infusion bag. When the infusion is completed, the holder 8 is removed from the infusion bag, and an infusion set is connected to the infusion bag and used for administration to the patient. Note that, instead of the sealing material 6 in FIG.
When the donut-shaped sealing material 60 shown in FIG.
And may be firmly joined so that they cannot be peeled off. Then, the plunger 4 is directly inserted into the exposed concave portion 73 of the positioning member 7.
And the plunger 4 is pressed in the distal direction, so that the bonding between the sealing member 60 and the base end surface 75 of the positioning member 7 by adhesion, fusion or the like is separated, and the gasket main body 3
Moves toward the distal end and injects the drug solution 10 into the infusion bag.
Can be blended.

The following method can be adopted instead of the above steps [4], [5] and [6]. [4 '] After the step [3], the holder 8 is removed from the cap 5, and the cap 5 is further rotated with respect to the container body 2,
The cap 5 is removed from the mouth 21. In addition, cap 5
The advantage of removing the holder 8 from the above-mentioned process [6]
It is the same as described above. [5 ′] On the other hand, a puncture needle (not shown) having a hub that can be tapered or screwed into the mouth 21 in a liquid-tight manner is prepared in advance, and the hub of the puncture needle is fitted into the mouth 21. I do. [6 ′] Next, the puncture needle is punctured into a co-injection port or the like of a patient's blood vessel or another predetermined container, the plunger 4 is pressed toward the distal end, and the gasket main body 3 is slid in the same direction. As a result, the drug solution 10 in the space 25 is discharged through the mouth 21 and the puncture needle, and is administered to a patient, or is injected and blended into the container. As described above, the liquid injector according to the present invention has been described with reference to the illustrated embodiments. However, the present invention is not limited to these embodiments. In particular, each component of the liquid injector according to the present invention exhibits the same function. It can be replaced with anything that can. Also, by increasing the diameter of the container main body and shortening the length of the container main body by that amount, it is possible to reduce the size of the drug solution injector.

[0022]

As described above, according to the drug solution injection device of the present invention, the drug solution such as the compounding of the drug solution into the bag can be performed in a short time by a simple operation. In particular, since the space surrounded by the container body and the sealing material is in a reduced pressure state, the solution is sucked without performing the operation of pulling the plunger, and the operation can be performed simply and quickly. In addition, during the operation, since there is very little chance that various places such as the space inside the container main body come into contact with the outside air, it is possible to prevent bacterial contamination and contamination of foreign matter. Further, by providing the sealing means and the sealing material, the depressurized state of the space can be more stably maintained for a long period of time, and the depressurized state in the container can be favorably maintained without impairing the slidability of the gasket. can do. Further, by setting in advance the amount of the medicine or the like to be stored in the container body, it is possible to prevent a compounding error.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing one embodiment of a drug solution injector according to the present invention.

FIG. 2 is a partial schematic view showing another embodiment of the cap portion of the drug solution injector according to the present invention.

FIG. 3 is a longitudinal sectional view showing another embodiment of the airtight maintenance member of the drug solution injector according to the present invention.

FIG. 4 is a partial sectional view taken along line AA ′ of the holder shown in FIG. 2;

Claims (9)

[Claims] 1. A cylindrical container main body having a front end closing part and a base end opening part, a cap provided at the front end of the container main body and hermetically closing an opening for communicating between the inside and the outside of the container main body, and the inside of the container main body. A gasket that slides in a liquid-tight manner, and a drug solution injector in which a medicine is stored in a space defined by a container body, a cap, and a gasket, wherein the base end opening is airtightly covered with an airtight maintenance member. The gasket is disposed at a predetermined position in the container main body, and the inside of the container main body is decompressed. 2. The liquid injector according to claim 1, wherein the gasket is detachably joined to the airtight maintenance member. 3. The liquid injector according to claim 1, wherein the base end of the gasket is a positioning part for preventing the gasket from moving toward the base end of the syringe when the space returns to normal pressure. 4. The liquid injector according to claim 3, wherein a plunger mounting portion is provided at a base end of the positioning portion. 5. The liquid injector according to claim 1, wherein the airtight maintaining member is piercable by a plunger. 6. The chemical injection device according to claim 1, wherein a deoxygenating agent and / or a desiccant is stored in a space on the base end side of the gasket inside the container body. 7. A cylindrical container main body having a distal end closing portion and a base end opening portion, a cap provided at a distal end of the container main body and hermetically closing an opening for communicating the inside and outside of the container main body, and a container internal portion. And a gasket that slides in a liquid-tight manner, and a drug solution injection device containing a medicine in a space defined by a container body, a cap, and a gasket. A liquid injector having a waterproof film, a base end of a gasket is releasably joined to the airtight film, and the inside of the container body is depressurized. 8. A container body having a cylindrical shape having a distal end closing portion and a base end opening portion, a cap provided at a distal end of the container body and hermetically closing an opening for communicating between the inside and outside of the container body, and an inside of the container body. A gasket that slides in a liquid-tight manner, and a medicine injecting device in which a medicine is stored in a space defined by a container body, a cap, and a gasket. A liquid injector comprising a member, a base end of a gasket is detachably joined to the airtight maintenance member, and the inside of the container body is depressurized. 9. The liquid injector according to claim 8, wherein a plunger mounting portion is provided at a base end of the gasket, and the plunger mounting portion is exposed through an annular cutout of the airtight maintenance member. Appliances.