JPH1087440A - Hair tonic cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a hair tonic cosmetic excellent in hair growth effects and effects for preventing alopecia. SOLUTION: This hair tonic cosmetic contains at least one or more substances selected from the group consisting of an extract separated from a fruit of an acerola, an extract of Swertia Herba, an extract of Ginseng Radix, an extract of a duke, an extract of a Capsicum tincture, diisopropylamine dichloroacetate, a γ-aminobutyric acid derivative, hinokitiol, a vitamin E derivative, a pantothenic acid derivative, a nicotinic acid derivative, a glycyrrhizic acid derivative and a glycyrrhetinic acid derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic having an excellent hair-growth effect and an effect of preventing hair loss.

[0002]

2. Description of the Related Art Conventionally, hair restoration cosmetics containing a blood circulation promoting substance such as pepper tincture and nicotinic acid derivatives, and amino acids and vitamins which are nutritional components of hair have been known. Have been.
Further, many medical hair restorers and cosmetics containing a component having an effect of preventing sebaceous gland hypertrophy and a component having an androgenic inhibitory effect have been proposed.

[0003] However, conventionally used blood circulation promoting substances are highly irritating to the skin, and the amount thereof is limited,
The disadvantage is that the duration of blood circulation promotion is short. In addition, there is also a problem that the hair nutrient has low permeability to the skin at a low concentration, and its effect is not sufficiently exhibited by itself.

[0004] By the way, androgenetic alopecia is said to be one of the causes of the excessive action of male hormones. Phenomena such as poor circulation, decreased activity of hair matrix cells, enlargement of sebaceous glands, fibrosis of the scalp, and the like are considered. It is presumed that it is caused by complicated intertwining.

[0005] However, even if an anti-androgen agent is simply used as a hair restorer to suppress hair matrix cell activity reduction and sebaceous gland hypertrophy, which are said to be caused by excessive action of androgen, the hair growth effect is exhibited. At present it does not reach. In addition, good results cannot be obtained even when the hair matrix activator or the blood circulation promoter is used alone.

As a means for solving the above-mentioned problems, a hair restorer composition containing fatty acids and alcohols having an odd carbon number, hydroxypropyl alcohol and a lower alcohol disclosed in JP-A-5-58850 is disclosed. Numerous hair growth and hair growth, such as a hair growth agent containing certain carboxybetaines described in JP-A-5-139936, a hair growth cosmetic containing an acidic mucopolysaccharide and a hop extract described in JP-A-5-170625, and the like. Agents have been proposed, but using a substance that promotes peripheral blood flow and activates hair matrix cells alone has not found any remarkable hair-growth effect, and has a satisfactory effect in the composition. In fact, there was room for improvement in the hair growth effect and the hair loss prevention effect.

[0007]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies on substances that promote peripheral blood flow of the scalp and activate hair matrix cells.
Extracts extracted from acerola fruit, assembly extract, Korean carrot extract, Duke extract, pepper tincture, diisopropylamine dichloroacetate, γ
Hair growth cosmetics containing at least one substance selected from the group consisting of aminobutyric acid derivatives, hinokitiol, vitamin E derivatives, pantothenic acid derivatives, nicotinic acid derivatives, glycyrrhizic acid derivatives, and glycyrrhetinic acid derivatives, a synergistic combination of the components. The present inventors have found that an excellent hair-growth effect and a hair loss-preventing effect, which are the objects of the present invention, are exhibited by the effects, and completed the present invention.

[0008] More specifically, an extract extracted from the fruit of acerola, an assembly extract, a Korean ginseng extract, a Duke extract, a red pepper tincture, diisopropylamine dichloroacetate, a γ-aminobutyric acid derivative, a hinokitiol, a vitamin E derivative, a pantothenic acid derivative, nicotinic acid The object of the present invention is achieved by a hair growth cosmetic containing at least one or more substances selected from the group consisting of derivatives, glycyrrhizic acid derivatives, and glycyrrhetinic acid derivatives.

[0009]

Embodiments of the present invention will be described below in detail.

[0010] Acerola (Malpighia glabra Linne) is an evergreen shrub native to Latin America that bears small red berries similar to cherries. This fruit contains a large amount of L-ascorbic acid and is used as a food material.

The extract extracted from the fruit of acerola used in the present invention is produced by the method disclosed in JP-A-2-200610 and the like. In addition to L-ascorbic acid, amino acids, organic acids, sugars, It also contains useful substances such as pectin. It is well known that an extract extracted from this acerola fruit is incorporated into cosmetics (Japanese Patent Laid-Open No. 2-2 / 1990).
No. 6010). However, the effect on hair growth cosmetics is not known at present.

The following is an example of a method for extracting an extract from the fruit of acerola. <Extraction Example 1> Acerola fruits are washed with water and pressed to obtain a pressed juice. The precipitate is removed by filtration, decantation or the like, and concentrated under reduced pressure as necessary. Thereafter, if necessary, ethanol, propylene glycol and the like are added, and the mixture is allowed to stand at a low temperature. Thereafter, the formed precipitate is removed by filtration again, and if necessary, an extract is obtained by filtration using a membrane filter having a pore size of 0.22 μm.

<Extraction Example 2> Acerola fruit is finely pulverized, and glycerin, 1,3-butylene glycol, propylene glycol, ethanol, water, etc. are used alone or as a mixture as an extraction solvent. Extract by immersion. The extract is concentrated under reduced pressure as necessary, filtered,
The extract is clarified by decantation or the like, and if necessary, filtered using a membrane filter having a pore size of 0.22 μm to obtain an extract.

<Extraction Example 3> The extract obtained in Extraction Example 1 or 2 is re-extracted with another solvent. Thereafter, if necessary, the extract is obtained by filtration using a membrane filter having a pore size of 0.22 μm. By selecting a solvent, it is possible to remove some components, and it is possible to obtain an extract suitable for blending into a hair nourishing cosmetic.

The scope of the present invention, which shows a hair-growth effect and a hair-loss preventing effect, was examined. As a result, the compounding amount of the extract extracted from the fruit of the acerola according to the present invention obtained by the above method was 0.001% of the hair restoration cosmetic when the weight ratio between the fruit used for the extraction and the obtained extract was 1. It is sufficient if it is 20 wt% (hereinafter abbreviated as wt%), and more preferably 0.01 to 10 wt%.

The γ-aminobutyric acid derivative used in the present invention is a known compound, and includes γ-aminobutyric acid, γ-amino-β-
Hydroxybutyric acid may be mentioned as a particularly preferable one, but is not limited thereto.

The vitamin E derivative used in the present invention is a known compound, and vitamin E, vitamin E acetate, and vitamin E nicotinate are particularly preferred, but are not limited thereto.

The pantothenic acid derivative used in the present invention is a known compound, and pantothenyl alcohol and calcium pantothenate can be mentioned as particularly preferable ones, but are not limited thereto.

The nicotinic acid derivative used in the present invention is a known compound, and benzyl nicotinate and nicotinamide are particularly preferable, but are not limited thereto.

The glycyrrhizic acid derivative used in the present invention is a known compound, and glycyrrhizic acid, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate can be mentioned as particularly preferable ones, but not limited thereto.

The glycyrrhetinic acid derivative used in the present invention is a known compound, and glycyrrhetinic acid and stearyl glycyrrhetinate can be mentioned as particularly preferable ones, but not limited thereto.

[0022] Then, the assembly extract and Korean carrot extract, Duke extract, pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid derivative, hinokitiol, vitamin E derivative, pantothenic acid derivative, nicotinic acid derivative, glycyrrhizic acid derivative,
The glycyrrhetinic acid derivative, as a result of examining the range showing the hair growth effect and the hair loss prevention effect, which are the objects of the present invention, should be 0.001 to 20.0 wt%, more preferably, based on the total amount of the hair restoration cosmetic. Is 0.01 to 5.0 wt%.

In the present invention, diisopropylamine dichloroacetate gives a particularly preferable result as a substance to be used in combination with the extract extracted from the fruit of acerola.

The hair nourishing cosmetic composition according to the present invention is manufactured in a usual manner into a dosage form such as a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, and the like. It is possible to use.

The hair-growing cosmetic composition according to the present invention is applied to a topical area (scalp) for the purpose of hair-growing, hair-growth and / or hair loss prevention by applying or spraying according to the dosage form.

The hair-growing cosmetic composition according to the present invention includes a pigment, a fragrance, a bactericide, a preservative, a surfactant, a pigment, a keratolytic agent, an anti-androgen agent and the like within a range in which the object of the present invention is achieved. They can be appropriately blended.

[0027]

The present invention will be described in detail below with reference to examples and comparative examples, but the present invention is not limited to these examples. The test method used in the present invention is as follows.

Practical Test Method Twice in the morning and evening twice daily on the head of 20 male pattern baldness patients
The effect after applying the sample for a month was evaluated. The test results are for hair growth and hair loss prevention.
The number of respondents who answered, "Regrowth of the raw hair or increase of the bristle", and "Reduction of hair loss" were indicated.

Examples 1 to 14 and Comparative Examples 1 to 16 (Heart Tonic) Hair tonics were prepared by mixing active ingredients as shown in Table 2 in the raw material compositions shown in Table 1, and the above-mentioned test was carried out.

The method of preparing an extract extracted from the fruit of acerola blended in the following Examples and Comparative Examples corresponds to Extraction Example 1 described above, and is specifically shown below.

Preparation Method of Extract from Acerola Fruit (Extraction Method) Acerola fruit (10 kg) was pressed to obtain a pressed juice.
This was concentrated under reduced pressure and filtered to obtain a filtrate (about 2 kg).
A 30 wt% aqueous solution of propylene glycol (18 k
g) was added, and the mixture was allowed to stand in a cool place for 7 days. Thereafter, the mixture was filtered to obtain an extract (about 20 kg).

[0032]

[Table 1]

(1) Preparation method After dissolving the component (B) shown in Table 1 in the component (A), the component (C) was added, and the mixture was stirred, dispersed and filled into a container.

(2) Characteristics

[0035]

[Table 2]

Table 2 shows the results of the tests for each hair tonic. As shown in Table 2, the hair restoration cosmetics according to the present invention of Examples 1 to 14 showed good results in practical tests, and the extracts extracted from the fruits of acerola showed the promotion of the hair growth effect and the hair loss prevention effect. Was. On the other hand, in Comparative Examples 1 to 16, the results of the practical test were not good.

It should be noted that, when any of the hair-growth cosmetics of any of the examples was used, no inflammation and other symptoms considered to be side effects occurred in humans, and the hair-growth cosmetic according to the present invention was excellent in safety. It was clear.

[0038]

EFFECTS OF THE INVENTION The hair restoration cosmetic according to the present invention has an activity of activating hair matrix cells and is excellent in hair growth effect, hair loss prevention effect and safety.

Claims (1)

[Claims] 1. An extract extracted from the fruit of acerola,
Assembly extract, Korean ginseng extract, Duke extract, Pepper tincture, diisopropylamine dichloroacetate, γ-aminobutyric acid derivative, hinokitiol,
A hair restoration cosmetic comprising at least one substance selected from the group consisting of vitamin E derivatives, pantothenic acid derivatives, nicotinic acid derivatives, glycyrrhizic acid derivatives and glycyrrhetinic acid derivatives.