JPH10309306A - Medicine injection instrument - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a medicine injection instrument which can perform the injection or combination of medicine through simple operation in a short time without generating any contamination. SOLUTION: A medicine injection instrument 1A is mainly composed of a main body 2 of vessel, gasket 3 which can be slid liquid-tightly along with the inner peripheral surface of this main body 2 of a vessel, plunger 4 for the slide operation of this gasket, cap 5, lock means 6 and seal member 7. The cap 5 is mounted at a port part 21 on the main body 2 of vessel and air-tightly seals the port part 21 through a sealing member 53. A space 25 surrounded with the main body 2 of vessel, gasket 3 and sealing member 53 is turned into pressure reduced state and solid medicines are stored. The lock means 6 is composed of a pair of projecting parts 61 protruded and formed around the outer periphery of axial part 41 on the plunger 4 and an engage member 62 mounted on the base end face of the main body of vessel and through the engagement of these components, the gasket 3 and plunger 4 are blocked from moving toward the top end.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a drug solution injection device, and more particularly to a drug solution injection device used for compounding a drug solution.

[0002]

2. Description of the Related Art Prior to administration of an infusion to a patient, drugs such as vitamins, heparin and antibiotics are added to the infusion filled in the infusion bag as required. I have.

[0003] To mix such a drug, first, a puncture needle of a syringe (syringe) is pierced into an elastic stopper of an infusion bag,
Pull the plunger to collect the infusion in the infusion bag into the syringe, and then transfer it to the container containing the drug (powder) containing the collected infusion, and dissolve and mix the drug in this container. Then, the drug mixture is suctioned and collected again with the syringe, the puncture needle of the syringe is inserted again into the elastic stopper of the infusion bag, and the plunger is pushed to inject the drug mixture into the infusion bag.

[0004] In addition, a puncture needle of a syringe is punctured into a rubber lid member of a vial in which a drug solution is sealed, and a plunger is pulled to collect the drug solution in the vial into the syringe.
It is performed by inserting a puncture needle of a syringe into an elastic stopper of an infusion bag and pushing a plunger to inject a drug solution into the infusion bag.

[0005] However, the composition of such a chemical solution is as follows.
There is a disadvantage that the operation procedure is complicated and the time required for blending is long. In particular, prompt response is essential for emergency patients, but it is disadvantageous when formulating a drug solution to be administered to such patients.

Furthermore, since the compounding operation of the above-mentioned chemical solution, particularly the dissolution and mixing of the chemical, are mostly carried out in contact with the atmosphere, there is a risk of bacterial contamination and foreign matter contamination.

[0007]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a chemical injection device which can perform injection and blending of a chemical solution in a short time by a simple operation without causing contamination.

[0008]

This and other objects are achieved by the present invention which is defined below as (1) to (17).

(1) A cylindrical container main body having a mouth formed on the distal end side, a gasket slidable along the inner peripheral surface of the container main body in a liquid-tight manner, and the gasket connected to the gasket, A plunger that slides and a liquid injector having sealing means for hermetically sealing the opening, wherein a space surrounded by the container body and the gasket is in a depressurized state, A liquid injection device provided with locking means for preventing movement of the gasket in a direction in which the volume of the space decreases.

(2) The chemical injection device according to the above (1), wherein the sealing means includes a sealing member that can be pierced with a needle tube.

(3) The chemical liquid injector according to the above (2), wherein the sealing member is a membrane or a plug made of an elastic body.

(4) The sealing means is provided on the cap body mounted around the mouth and the cap body, and the sealing means is in close contact with an end face of the mouth when the cap body is mounted. The liquid injector according to the above (1), which comprises a sealing member for hermetically sealing the device.

(5) The liquid injector according to (4), wherein the cap body is detachably attached to the mouth.

(6) The lock means includes at least one protrusion formed on the plunger, and an engaging member mounted on a base end of the container body and engaged with the protrusion. The drug solution injector according to any one of the above (1) to (4).

(7) The locking means according to (6), wherein the locking means is configured to release the lock between the projection and the engaging member by rotating the plunger. The drug solution injector according to the above.

(8) The liquid injector according to (6), wherein the protrusion is formed by deforming the plunger.

(9) The chemical liquid injector according to the above (8), wherein the plunger has a link mechanism at a shaft portion, and the link mechanism is deformed to form the protrusion.

(10) The chemical liquid injector according to the above (8) or (9), further comprising state holding means capable of holding at least one of a deformed state and a non-deformed state of the plunger.

(11) The chemical injection device according to any one of (1) to (10), wherein the locking means can restrict the position of the gasket in the sliding direction to another stage.

(12) The chemical liquid injector according to any one of (1) to (11), wherein the depressurized state of the space is maintained by airtight holding means provided on a base end side of the gasket.

(13) The chemical liquid injector according to the above (12), wherein the airtight holding means has a flange formed on the plunger and located on a proximal end side of the gasket.

(14) The chemical according to the above (12), wherein the airtight holding means is formed on the plunger, and includes a flange located on the base end side of the gasket, and a seal member closely contacting the flange. Infusion device.

(15) Airtight holding means for maintaining a reduced pressure state in the space, wherein the airtight holding means is formed on the plunger and is located at a base end side of the gasket; (6) to (1), which are composed of a sealing member that is in close contact with the engaging member.
The drug solution injector according to any of 1).

(16) A bottomed cylindrical container body, and a gasket slidable in a liquid-tight manner along the inner peripheral surface of the container body.
A chemical liquid injector having a connecting member connected to the gasket and having a flow path therein, and sealing means for hermetically sealing one end of the flow path, wherein the container body and the gasket are A liquid injector is characterized in that the enclosed space is in a depressurized state and provided with a lock means for preventing the gasket from moving in a direction in which the volume of the space decreases.

(17) The drug solution injector according to any one of (1) to (16), wherein a drug is stored in the space.

[0026]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a perspective view of a liquid injector according to the present invention.

FIG. 1 is a longitudinal sectional view showing an embodiment of a drug solution injection device of the present invention, FIGS. 2 and 3 are views taken along line AA in FIG. 1, respectively, and FIG. FIG. 5 is a vertical cross-sectional view of a holder with a double-ended needle attached to an injection device, FIG. 5 is a vertical cross-sectional view showing a state where the holder shown in FIG. 4 is mounted on the drug solution injection device of the present invention, and FIG. It is a longitudinal cross-sectional view which shows the state at the time of injection | pouring of a chemical | medical solution of an apparatus. For convenience of explanation,
1 and FIGS. 4 to 6, the upper side is referred to as “distal end”, and the lower side is referred to as “proximal end”.

As shown in FIG. 1, a chemical liquid injector 1A of the present invention mainly comprises a container body 2, a gasket 3 which can slide in a liquid-tight manner along the inner peripheral surface of the container body 2, and a It comprises a plunger 4 for sliding the gasket, a cap 5 as sealing means, a locking means 6, and a sealing member 7 as airtight holding means. Hereinafter, these components will be sequentially described.

The container body 2 is formed of a bottomed cylindrical body having a protruding opening 21 functioning as a chemical liquid discharge port at the tip, and is made of a rigid material having a predetermined rigidity.

As a constituent material of the container body 2, for example,
Polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4
-Methylpentene-1), acrylic resin, polyacrylonitrile, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, polyester such as polybutylene terephthalate, polyethylene naphthalate, polyethylene naphthalate-polyethylene terephthalate copolymer, polyvinylidene fluoride, Various resins such as butadiene-styrene copolymers and cyclic polyolefins, or blends containing these resins, polymer alloys, and the like are included.

Of these materials, polyethylene, polypropylene, cyclic polyolefin, polycarbonate, poly- (4-methylpentene-
Resins such as 1) are preferred.

Further, in order to maintain the decompressed state of the space 25 in the container main body 2, the constituent material of the container main body 2 preferably has a gas barrier property (gas impermeable). Because of this high gas barrier property, the constituent material of the container body 2 is
Polyesters such as polyethylene terephthalate, polyethylene naphthalate, and polyethylene naphthalate-polyethylene terephthalate copolymer, polyacrylonitrile, and polyvinylidene fluoride are preferred.

Preferably, the constituent material of the container body 2 is substantially transparent or translucent in order to secure the visibility of the inside.

In order to improve the gas barrier properties, a gas barrier layer (not shown) may be formed on the surface of the container body 2 by, for example, vapor deposition, sputtering, or the like.
Examples of the composition of the gas barrier layer include oxides such as silicon oxide, aluminum oxide, and titanium oxide.

The container body 2 may be made of a metal material such as stainless steel, titanium, aluminum or the like, or a ceramic material such as glass or alumina, in addition to the above materials.

A flange 23 is provided on the outer periphery of the base end of the container body 2.
Are formed. The mouth portion 21 is formed of a cylindrical body having a tapered portion having an outer diameter tapering toward the distal end at least, and a male screw 22 is formed on the outer peripheral surface on the base end side.

A gasket 3 slidable in a liquid-tight manner along the inner peripheral surface of the container body 2 is inserted into the container body 2. The gasket 3 is a substantially columnar member made of an elastic material. Specific examples of the constituent material of the gasket 3 include various rubber materials (especially vulcanized) such as natural rubber, isoprene rubber, butyl rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, and polyester. And various thermoplastic elastomers such as polyamide, olefin, and styrene, and mixtures thereof. Among them, butyl rubber is excellent in chemical resistance (particularly insoluble in chemicals). Styrene-based elastomers are particularly preferred.

Further, in order to improve gas barrier properties,
The above-described gas barrier layer (not shown) can be formed on the surface (for example, the base end surface) or inside of the gasket 3.

The gasket 3 is not limited to the whole made of the elastic material, but may be any as long as at least the protrusion 31 is made of the elastic material.

A plurality of ring-shaped projections 31 are formed on the outer peripheral surface of the gasket 3 over the entire circumference. The protrusion 31 is in close contact with the inner peripheral surface of the container main body 10, and when the gasket 3 slides with respect to the container main body 2, the state in which the protrusion 31 is in close contact with the inner peripheral surface of the container main body 10 is maintained. Hold. In addition, the protrusion 31 also has a function of maintaining an appropriate slidability of the gasket 3.

In order to maintain good liquid tightness of the gasket 3 with respect to the container body 2, the maximum outer diameter of the gasket 3, that is, the outer diameter of the ring-shaped projection 31 is smaller than the inner diameter of the container body 2. Is preferred.

In order to further improve liquid tightness and slidability, a plurality of protrusions 31 are provided at predetermined intervals along the longitudinal direction of the container body 2 (in this embodiment, as shown). 3)
It is preferably formed.

The gasket 3 which is in close contact with the inner peripheral surface of the container body 2 is preferably capable of ensuring the airtightness of the space 25 by itself, but is not capable of completely maintaining the airtightness. You may. In this case, the airtightness is ensured or improved by installing a seal member 7 described later,
Maintain the reduced pressure state of 5.

In order to enable connection with the plunger 4, an umbrella-shaped (mushroom-shaped) concave portion 32 is formed in the center of the inside of the gasket 3.

The tip of the plunger 4 is connected to such a gasket 3. That is, the plunger 4
It has a shaft portion 41 and an umbrella-shaped (mushroom-shaped) head portion 42 formed on the distal end side. The head portion 42 is fitted into and engaged with the concave portion 32 of the gasket 3, and is connected to the gasket 3.

The connection structure between the gasket 3 and the plunger 4 is not limited to the illustrated example, but may be any structure in which the connection is not easily released, such as a screw structure of a male screw and a female screw. Any configuration may be used.

A handle 43 for gripping and operating the plunger 4 by hand is formed at the base end of the plunger 4.

A pair of plate-like protrusions 61 are formed on the outer periphery of the shaft portion 41 on the tip end side at positions opposed to each other via the axis. The both protrusions 61 may be formed integrally with the shaft 41, or may be formed by joining separate members (adhesion, fusion, fitting, caulking, screwing, etc.). This protrusion 61
Constitutes the locking means 6 together with an engagement member 62 described later. The number of the protrusions 61 may be one or three or more.

The mouth 21 is provided at the tip end of the container body 2.
(Sealing means) 5 that hermetically seals is provided. The cap 5 includes a cap body 51 detachably mounted (screwed) around the mouth 21, and a sealing member 53 installed inside the cap body 51.

A female screw 52 for screwing with the male screw 22 is formed on the inner peripheral surface of the base end portion of the cap main body 51. The female screw 52 and the male screw 22 are screwed to form the cap main body 51. It is mounted around the mouth 21.

The sealing member 53 is formed of a membrane or a plug made of an elastic material such as various rubbers or thermoplastic elastomers as described above, and can be pierced by a second needle tube 832 described later. It is airtight in itself.

In order to improve the gas barrier properties,
A gas barrier layer (not shown) as described above can be formed on the surface or inside of the sealing member 53.

When the cap body 51 is screwed into the mouth portion 21 and mounted, the tip end surface of the mouth portion 21 comes into close contact (compression bonding) with the sealing member 53, whereby the mouth portion 21 is hermetically sealed. , The pressure in the space 25 can be maintained.

A tapered guide surface 54 whose inner diameter gradually increases toward the distal end is formed on the distal end side of the sealing member 53 of the cap body 51. This guide surface 54
Plays a role in guiding the needle point 834 of the second needle tube 832 to the center of the sealing member 53 when the sealing member 53 is pierced with the second needle tube 832.

The space 25 in the container body 2 surrounded by the container body 2, the gasket 3, and the sealing member 53 as described above
The pressure is reduced. In this case, the pressure in the space 25 is
About 40-600 torr is preferable, and about 70-200 torr is more preferable. If the pressure in the space 25 is too low, the flow of the liquid into the space 25 is completed (step [2] described later).
), The rate of closing the liquid in the space 25 increases (the number of air bubbles decreases), and the solubility and agitation when the medicine is dissolved by shaking the container body 2 are reduced.
On the other hand, if the pressure in the space 25 is too high, the inflow speed and the amount of inflow of the liquid into the space 25 decrease.

Although not shown, the space 25 contains a medicine, particularly a solid (eg, powder, granule, block (tablet), or gel) medicine, as necessary.
The type of the drug is not particularly limited, for example, antibiotics, vitamins (multivitamins), various amino acids, antithrombotics such as heparin, insulin, antitumor agents, analgesics,
It may be any of cardiotonic agents, intravenous anesthetics, antiparkinson agents, antiviral agents, immunostimulants, ulcer treatment agents, corticosteroids, arrhythmia agents, correction electrolytes, and the like.

The form of the drug is not limited to a solid, but may be a drug solution. Further, two or more drugs may be mixed.

As described above, since the space 25 is in a depressurized state, the gasket 3 and the plunger 4 move in the distal direction (the direction in which the volume of the space 25 decreases) due to the pressure difference between the pressure in the space 25 and the atmospheric pressure. ). Space 25
It is necessary to prevent the gasket 3 and the plunger 4 from moving in the distal direction due to this stress in order to maintain the pressure in a desired reduced pressure state.

In this case, the pressure acting on the gasket 3 and the plunger 4 is reduced by setting the pressure in the space 25 to be relatively high, or the adhesion of the gasket 3 to the inner peripheral surface of the container body 2 is enhanced. Then, a method of increasing the static frictional force of the gasket 3 against the stress can be considered. However, in the former case, there is a disadvantage that the suction amount and the suction speed of the liquid into the space 25 decrease, and in the latter case, The plunger 4 is pressed and moved in the distal direction to move the space 25.
When the liquid inside is discharged, the sliding property of the gasket 3 is deteriorated, and there is a disadvantage that the operation is difficult.

Therefore, in the present invention, the good sliding property of the gasket 3 at the time of the moving operation of the plunger 4 is ensured, and the gasket 3 is moved in the distal direction (the volume of the space 25) by reducing the pressure of the space 25. (In the direction of decreasing).

The locking means 6 includes a pair of plate-like projections 6 formed on the outer periphery of the shaft 41 of the plunger 4 on the distal end side.
1 and an engaging member 62 attached to the base end surface of the container body 2.

The engaging member 62 is formed of a disk-shaped member, and is mounted so as to be fitted to the flange 23 of the container body 2. The engaging member 62 is preferably bonded or fused (heat fusion, ultrasonic fusion, or the like) to the flange 23 or a sealing member 7 described later with an adhesive. Is preferably adhered or fused in an airtight manner.

An opening 63 having a shape as shown in FIGS. 2 and 3 is formed at the center of the engaging member 62. The opening 63 has a substantially circular portion 6 with which the projections 61 can engage.
4 and a pair of long holes 65 through which both protrusions 61 can pass.

It is sufficient that the long hole portion 65 is formed to correspond to the projection 61, and the pair of projections 61 in the present embodiment is, for example, four crosses arranged in a cross shape.
The long holes 65 may be formed.

As described above, the gasket 3 and the plunger 4 connected to the gasket 3 are stressed in the distal direction, but as shown in FIGS. When it is located at 64, the two protrusions 61 are engaged with the engagement members 62, and the gasket 3 and the plunger 4 are prevented from moving in the distal direction. That is, the locking by the locking means 6 is performed. This allows
During storage of the drug solution injector 1A or the like, the decompressed state of the space 25 is maintained.

Also, from the state shown in FIG.
Is rotated by about 90 °, the protrusions 61 are located in the long hole portion 65 of the opening 63, and can pass through the long hole portion 65 and move to the distal end side from the engagement member 62. That is, the lock by the lock means 6 is released. This allows
The plunger 4 is pressed and moved in the tip direction to move the gasket 3
Can be moved in the same direction, and the liquid medicine or the like in the space 25 can be discharged.

In order to prevent the slidability of the gasket 3 from deteriorating, for example, when the adhesive force of the gasket 3 to the container main body 2 is suppressed to some extent, the gas-tightness of the base end side of the container main body 2 by the gasket 3 alone is used. In some cases, it is difficult to secure sufficient airtightness, particularly, to maintain the airtightness for a long period of time. In such a case, if necessary, the seal member 7 is attached as an airtight holding means, and the airtight state of the space 25 is reliably maintained.

The sealing member 7 is a disk-shaped (ring-shaped) member made of the above-described elastic material, and does not hinder the movement of the plunger 4 in the distal direction when the lock is released. An opening 71 is formed. The opening 71 preferably has a shape corresponding to the opening 63 and has a slightly larger dimension so that the projection 61 does not interfere with the seal member 7 when the projection 61 passes through the opening 63.

As shown in FIG. 1, this sealing member 7
Due to its own elasticity, the outer peripheral surface 72 is preferably fitted into the base end of the container main body 2 such that the outer peripheral surface 72 is in close contact with the inner peripheral surface of the container main body 2.

More specifically, when the lock by the lock means 6 is released, the outer peripheral surface 72 of the seal member 7 is in close contact with the inner peripheral surface of the container body 2 with a predetermined adhesive force (see FIG. 6). ) Or approaching, while being locked by the locking means 6,
Is sandwiched between the gasket 3 and the engaging member 62 so that the distal end face of the seal member 7 and the proximal end face of the gasket 3 are in close contact with each other, and the thickness of the seal member 7 is reduced. It is preferable that the outer peripheral surface 72 be configured so as to increase the adhesion force to the peripheral surface (see FIG. 1). Thereby, more excellent airtightness can be obtained.

The installation of the seal member 7 can improve the airtightness of the base end of the container body 2 without lowering the slidability of the gasket 3, that is, the operability of the plunger 4. Demonstrate.

Grease or other gel-like material may be attached to the seal member 7 in order to improve the airtightness with other parts to which the seal member 7 is in close contact. The gasket 3 can be provided with such a deposit.
Thereby, the medicine in the space 25 is blocked, and the medicine does not come into contact with the attached matter.

Next, with reference to FIG. 4, the structure of the holder 8 used by being attached to the drug solution injector 1A will be described.

The holder 8 has a cylindrical holder body 81 whose base end is open. This holder body 81
It has a shape and dimensions that allow the cap 5 to be inserted through the base end opening 811 and fitted.

On the inner peripheral surface of the tip of the holder body 81,
A female screw 82 is formed. A double-ended needle 83 is attached to the tip of the holder body 81.

The double-ended needle 83 is connected to the hub 84 such that the first needle tube 831 and the second needle tube 832 are connected so that their needle tips 833 and 834 face in opposite directions and their bores communicate with each other. Is fixed to the

The first needle tube 831 and the second needle tube 832 are
Each is made of various metal materials such as stainless steel, titanium, and aluminum. Also, glass,
Various ceramic materials such as alumina, polyester,
It may be composed of various hard resins such as polyphenylene sulfide and polycarbonate.

A male screw 85 is formed on the outer periphery of the hub 84, and the double-ended needle 83 is attached to the holder 81 by screwing the male screw 85 to the female screw 82.

An enclosing member 87 for enclosing at least the needle tip 834 is provided around the second needle tube 832.
The encapsulating member 87 has a function of preventing contamination of the second needle tube 832 and the like when not in use, maintaining a sterile state, and a function of preventing liquid leakage from the needle tip 834.

The enclosing member 87 is preferably made of a film made of the above-mentioned elastic material, and can be easily penetrated by the needle point 834.

The distal end of the enclosing member 87 is fitted into a protruding portion 86 protruding from the base end of the hub 84, and is preferably bonded and fixed with an adhesive. The base end of the enclosing member 87 has a hemispherical shape.

Next, an example of a method of use (operation) of the drug solution injector 1A will be described with reference to FIGS.

[1] An unused chemical injector 1A shown in FIG. 1 is prepared. The space 25 maintains a predetermined decompressed state, and the space 25 stores a predetermined amount of a solid drug such as a powder. In this state, the gasket 3 and the plunger 4 are
To maintain a state of stopping at the base end side of the container body 2.

[2] On the other hand, a container containing a liquid to be mixed with a chemical is prepared. In the present embodiment, an infusion bag (not shown) containing an infusion is described as an example.

The double-ended needle 8 of the holder 8 is connected to the co-injection port (constituted by a plug made of an elastic material) of the infusion bag.
3, and the cap 5 of the drug solution injector 1A is inserted and fitted into the holder main body 81 as shown in FIG. Thereby, the second needle tube 83
2 pierces the sealing member 53, and the needle tip 834 thereof
Invades the lumen.

At this time, the tip of the encapsulating member 87 is pierced through the second needle tube 832, and is pressed by the sealing member 53 and the guide surface 54 toward the tip, thereby forming a bellows shape. Will be folded. Then, the needle tip 834 of the needle tube 831 is guided by the guide surface 54 and is guided to the central portion of the sealing member 53, so that the sealing member 53 can be reliably inserted at an appropriate position.

As described above, the inside of the infusion bag and the space 2
5 communicates through the double-ended needle 83, the space 25 is in a reduced pressure state, and the infusion in the infusion bag is in the first state.
Flows into the space 25 through the lumens of the needle tube 831 and the second needle tube 832.

[3] When the infusion of the infusion into the space 25 is stopped, the liquid injector 1A is rocked and vibrated to give the space 2
The solid drug stored in 5 is dissolved in the infusion. Thereby, a desired chemical solution 9 to be blended is adjusted.

[4] Next, the plunger 4 is connected to the container body 2.
90 ° to the right or left. Thereby, both protrusions 61 can pass through the long hole portion 65 of the opening 63,
The lock by the lock means 6 is released.

[5] Subsequently, as shown in FIG. 6, the plunger 4 is pressed in the distal direction, and the gasket 3 is slid in the same direction. As a result, the drug solution 9 in the space 25 is injected into the infusion bag through the lumen of the mouth portion 21, the second needle tube 832, and the first needle tube 831, and is mixed therein.

[6] As described above, when the injection of the drug solution into the infusion bag is completed, the cap 5
Remove. Along with this, the second needle tube 832 is pulled out of the sealing member 53. At this time, the enclosing member 87 folded in a bellows shape is instantaneously restored to its original shape by its elastic force, and envelops the second needle tube 832 again. Is prevented from scattering.

Then, the infusion in the infusion bag is maintained in a sterile state by the action of resealing the covering member 87 and the co-injection port.

The following method can be adopted instead of the above steps [4], [5], and [6].

[4 '] After the step [3], the holder 8 is removed from the cap 5, and the cap 5 is rotated with respect to the container body 2 to remove the cap 5 from the mouth 21.
The advantages of removing the holder 8 from the cap 5 are the same as those described in the step [6].

[5 '] On the other hand, a puncture needle (not shown) having a hub that can be fitted (screwed) in a liquid-tight manner with the mouth 21 is prepared in advance, and the hub of the puncture needle is connected to the mouth 21. Fits.

[6 '] Next, the puncture needle is punctured into the co-injection port or the like of the patient's blood vessel or another predetermined container, and as shown in FIG. Slide the gasket 3. As a result, the drug solution 9 in the space 25 is discharged through the mouth 21 and the puncture needle, and is administered to a patient or injected and mixed into the container.

FIGS. 7 and 8 are longitudinal sectional views showing another embodiment of the drug solution injector of the present invention. Less than,
The liquid injector 1B of this embodiment is replaced with the liquid injector 1
The differences from A will be described.

The chemical injection device 1B differs from the chemical injection device 1A in the configuration of the locking means 6. That is, a pair of protrusions 61 similar to the above are formed on the outer periphery of the distal end side of the shaft portion 41 of the plunger 4, and the protrusion 61 is further formed on the outer periphery of the shaft portion 41 on the base end side. A similar pair of opposed protrusions 66 are formed to project.

In this case, both projections 66 are formed in a direction rotated by 90 ° with respect to both projections 61. Further, the position in the longitudinal direction of the both protrusions 66 with respect to the shaft portion 41 corresponds to the regulated amount of the volume of the space 25. That is, for example, the two protrusions 6
In the case where the volume of the space 25 is restricted to about か ら from the initial state by the use of 6, the distance between the two protrusions 61 and the two protrusions 66 in the longitudinal direction of the shaft is the maximum movement distance (stroke) of the plunger 4. About 1/2.

In the liquid injector 1B, the engagement between the projection 61 and the engaging member 62 is released, the plunger 4 is pressed toward the distal end, and the liquid 9 is discharged, as in the step [5]. Then, the projection 66 and the engaging member 62 are engaged, and at that point, the movement of the gasket 3 in the distal direction is again prevented. The discharge amount of the chemical solution 9 up to this point can be set to, for example, about の of the total discharge amount.

The plunger 4 is again rotated by 90 ° and the protrusion 6
The engagement between the engagement member 62 and the engagement member 62 is released, the plunger 4 is pressed toward the distal end, and the remaining chemical solution 9 (half the amount of the chemical solution) can be discharged.

Before and after the discharge of the chemical solution 9 in these two stages, the first
When the needle tube 831 is punctured and a container such as an infusion bag which is in communication is exchanged, it is possible to dispense a substantially equal amount of the drug solution 9 to a different container.

The number of the projections 61 and 66 may be one or three or more as described above. Further, the formation of such protrusions is not limited to two steps as in the present embodiment, but may be formed in three or more steps.
Further, the positions of the protrusions 61 and 66 can be made variable.

FIG. 9 is a sectional view showing another example of the structure of the airtightness maintaining means in the present invention. Note that the configuration other than the air-tightness maintaining means is the same as that of the chemical liquid injector 1A (or 1B), and therefore, the description thereof is omitted.

The airtight holding means shown in FIG.
And a disk-shaped flange 44 formed near the base end of the head portion 42, and the same sealing member 7 as described above.

The flange 44 is connected to the shaft 41 of the plunger 4.
Is formed integrally with the gasket 3.
In close contact with the base end face of The outer peripheral edge of the flange 44 is in close contact with the inner peripheral surface of the container body 2. The sealing member 7 is sandwiched between the flange 44 and the engaging member 62 so as to be in close contact with them, and the outer peripheral surface 72 of the sealing member 7
Is preferably in close contact with the inner peripheral surface of the container body 2.

As described above, the gasket 3 is made of an elastic material. However, due to its material characteristics, some gaskets 3 have a certain degree of gas permeability. The gasket 3 alone must ensure sufficient airtightness. May not be possible. In particular, in consideration of the slidability of the gasket 3, the gasket 3 alone may not be able to maintain the reduced pressure state of the space 25 in some cases. Therefore, by providing such an airtightness maintaining means, airtightness can be ensured or further improved, and the space 2
5 can be more stably maintained.

That is, the flange 44 made of a highly airtight material (particularly a hard resin material) is attached to the gasket 3.
By preventing the gas from entering the space 25 by passing through the material of the gasket 3, the outer peripheral edge of the flange 44 is in close contact with the inner peripheral surface of the container body 2, The airtightness near the boundary with the inner peripheral surface of the container body 2 can be increased without lowering the slidability of the gasket 3. Then, by the action of the seal member 7,
The airtightness is further improved.

The outer periphery of the flange 44 and the container body 2
In order to further improve the airtightness with the inner peripheral surface of the container body, for example, a ring-shaped concave or convex portion (not shown) is provided along the entire periphery of the inner peripheral surface of the container body 2, and the concave or convex portion It is also possible to adopt a configuration in which the outer peripheral edge of the flange 44 is engaged (fitted). When the plunger 4 is pressed, the flange 44 moves over the uneven portion.

The sealing member 7 has another simple shape,
It can be replaced with another form or the like, or can be omitted.

Incidentally, the sealing members 7 and / or
Alternatively, the installation of the hermeticity maintaining means constituted by the flange 44 and the like also contributes to downsizing of the liquid injector. That is, when maintaining the reduced pressure state of the space 25 by the gasket 3 alone,
The gasket 3 is made of a gas-impermeable elastic material, or the gas barrier layer is formed, and the slidability of the gasket 3 is not impaired while increasing the adhesion to the container body 2. In order to reduce the contact area with the inner peripheral surface of the container 2, it is necessary to reduce the inner diameter of the container body 2 to some extent. Therefore, in order to secure a required volume of the space 25, the length of the container body 2 must be increased to some extent. However, when the gasket 3 alone does not maintain the completely depressurized state of the space 25 and the airtight maintaining means maintains the depressurized state of the space 25, the gasket 3 does not suffer from the above-described restrictions, and therefore, the gasket 3 can slide properly. While securing the mobility
The inner and outer diameters of the container main body 2 can be increased, that is, the length of the container main body 2 can be shortened, so that the size of the chemical liquid injector can be reduced.

FIGS. 10 and 11 are side sectional views showing another example of the structure of the lock means according to the present invention, and FIGS.
FIG. 2 is a perspective view of the locking means. The locking means shown in these figures includes projections 61a, 61
b is a configuration formed by deformation of the plunger 4. The details will be described below.

The shaft portion 41 of the plunger 4 has four links 611, 612, 613, 614 formed by bending portions 615, 61.
6, 617, 618, 619, and 620 are provided so as to be rotatably connected to each other, and the link mechanism 610 is deformed to form protrusions 61a and 61b.

A pin 45 protruding toward the distal end is erected on the handle 43 of the plunger 4, and a head 403 is formed at the distal end. Also, the pin 45
A pair of locking claws 402, 402 projecting in the direction perpendicular to the pin 45 and in the directions opposite to each other are formed at an intermediate position. On the other hand, the links 611 and 612 have holes 4 into which the locking claws 402 and 402 are inserted and locked, respectively.
01 and 401 are formed, and a recess 404 into which the head 403 is fitted is formed near the base end of the head 42.

Of these, the plunger 4 is deformed by the head 403 and the recess 404 (the state shown in FIG. 10).
Is held, and each of the holes 401 and each of the locking claws 402 constitutes a non-deformed state of the plunger 4 (FIG. 1).
1), that is, a state holding unit that holds a state in which a pressing operation in a distal direction is possible.

As shown in FIG. 10, when the handle 43 of the plunger 4 is pressed in the distal direction to bend each of the bent portions 615 to 620, the link mechanism 610 is deformed, and the link 61 is deformed.
1, 613, and links 612, 614
Is formed. These projections 61
a, 61b cannot pass through the opening 67 of the engagement member 62,
It engages around it, thereby locking. At this time, since the head 403 is fitted into the concave portion 404, the deformed state of the plunger 4, that is, the locked state is maintained. Further, in this state, the depressurized state of the space 25 is reduced by the action of the airtightness maintaining means constituted by the flange 44 and the seal member 7 sandwiched between the flange 44 and the engaging member 62, as described above. Good retention.

As shown in FIG. 11, the head 403 and the recess 4
04, the handle portion 43 of the plunger 4 is pulled in the proximal direction, and each link 611-6 of the link mechanism 610 is pulled.
14 is extended to be substantially parallel to the axis of the shaft portion 41. As a result, the plunger 4 is in a non-deformed state, and the shaft portion 41 can pass through the opening 67 of the engaging member 62, that is, the lock by the lock means is released. At this time, since the locking claws 402, 402 are inserted and locked into the corresponding holes 401, 401, the non-deformed state of the plunger 4, that is, the unlocked state is maintained.

After the state shown in FIG. 11 is reached,
The step [5] and subsequent steps can be performed.

According to the above configuration, when the locking means is in the locked state, the plunger 4 is deformed and the protrusion 61
Since the a and 61b are formed, the length of the plunger 4 protruding toward the base end is shortened, and there is an advantage that the size can be reduced.

FIG. 13 shows another configuration of the state holding means. The state holding means shown in FIG.
14 are respectively formed with locking claws 631 and 634 protruding therefrom.
And holes 63 formed in the links 612 and 613, respectively.
2, 633.

In the deformed state of the plunger 4 (locked state corresponding to FIG. 10), the locking claw 631 is locked in the hole 633, and the locking claw 634 is locked in the hole 632, and this state is maintained. In a non-deformed state of the plunger 4 (an unlocked state corresponding to FIG. 11), the locking claw 631
And the locking claw 634 is locked in the hole 633 to maintain that state.

FIG. 14 shows still another configuration of the state holding means. The state holding means shown in the figure is not formed on each link as described above, but is provided on the engaging member 62 side. That is, the engaging member 62
Are formed with engaging claws 621 and 622 for supporting and fixing the protrusions 61a and 61b, respectively, as state holding means. In this case, the engaging claws 621 and 622 are
It has flexibility so that a and 61b can be detached.

As another state holding means, a structure in which the protrusions 61a and 61b are stopped with an adhesive tape or a belt may be used.

FIG. 15 is a longitudinal sectional view showing another example of the structure of the sealing means in the present invention. The sealing means shown in FIG.
Instead of the cap 5, the cap 5 is constituted by a plug 55 fitted into the tip of the mouth 21. As the plug body 55, one in which the entirety or at least a portion in close contact with the mouth 21 is made of the same elastic material as the sealing member 53 can be used.

The stopper 55 may or may not be penetrable by a needle such as the second needle 832.

In the sealing means composed of such a plug 55, the structure of the sealing means is simpler than that of the cap 5, and the male screw 22 does not need to be formed on the outer periphery of the mouth 21. There is an advantage that the structure of the container body 2 becomes simpler.

FIG. 16 is a longitudinal sectional view showing another embodiment of the drug solution injector of the present invention. Hereinafter, the points different from the liquid injector 1A will be mainly described.

A chemical injection device 1C shown in FIG. 16 includes a bottomed cylindrical container body 2, a gasket 3 similar to the above, and a plunger (connection member) 4 connected to the gasket 3.
And a cap 5 similar to the above, a locking means 6 similar to the above, and a sealing member 7 similar to the above.

The plunger 4 is formed with a head portion 42, which is connected to the gasket 3. Also,
A flange 44 similar to the above is formed on the plunger 4.

At the tip of the plunger 4, an opening 21 similar to the above is formed, and a cap 5 is attached to the opening 21.

The shaft 41 of the plunger 4 is formed of a hollow shaft, and has a flow passage 46 formed therein. With the cap 5 attached, the distal end of the flow path 46 is hermetically sealed by the sealing member 53. The flow path 46 communicates with the space 25 via a hole 33 formed in the center of the gasket 3.

In this liquid injector 1C, the holder 8 is attached to the mouth 21 in the same manner as described above, and the channel 4 is inserted into the space 25.
After the infusion is introduced through the container 6 and the medicine (not shown) stored in the space 25 is dissolved, the container main body 2 is rotated by 90 ° relative to the plunger 4 to lock by the locking means 6. Then, the container body 2 is pressed and moved in the distal direction (upward in FIG. 16) to reduce the volume of the space 25, and the chemical solution in the space 25 flows through the flow channel 46, the second needle tube 832 and the first needle tube 831. Drain through.

Although the liquid injector according to the present invention has been described with reference to the illustrated embodiments, the present invention is not limited to these embodiments. In particular, each component of the liquid injector according to the present invention has the same configuration as that of the first embodiment. It can be replaced with any one that can exert its function.

[0134]

As described above, according to the drug solution injection device of the present invention, a drug solution such as compounding of a drug solution into a bag can be performed in a short time by a simple operation. In particular, since the space surrounded by the container body and the gasket is in a reduced pressure state, the liquid is sucked without performing the operation of pulling the plunger, and the operation can be performed simply and quickly.

[0135] During the operation, there is very little chance that various places such as the space inside the container body come into contact with the outside air, so that it is possible to prevent bacterial contamination and contamination of foreign matter.

Further, by providing the sealing means, the airtight holding means, the locking means and the like, the reduced pressure state of the space can be more stably maintained for a long period of time.

In particular, it is possible to maintain a good decompressed state in the container without impairing the slidability of the gasket, and to increase the diameter of the container main body and shorten the length of the container main body accordingly. By maintaining the decompressed state in the container by deforming the plunger, it is possible to reduce the size of the drug solution injector.

The operation of releasing the lock by the lock means is easy, for example, only by rotating the plunger or returning the deformed plunger to its original shape.

In addition, by setting in advance the amounts of the chemicals and the like to be stored in the container body, it is possible to prevent a mixing mistake.

[Brief description of the drawings]

FIG. 1 is a longitudinal sectional view showing an embodiment of a drug solution injector according to the present invention.

FIG. 2 is a view along the line AA in FIG.

FIG. 3 is a view along the line AA in FIG. 1;

FIG. 4 is a vertical cross-sectional view of a double-ended needle holder to be attached to the drug solution injector of the present invention.

5 is a longitudinal sectional view showing a state in which the holder shown in FIG. 4 is mounted on the drug solution injector of the present invention.

FIG. 6 is a longitudinal sectional view showing a state at the time of injecting a drug solution of the drug solution injector according to the present invention.

FIG. 7 is a longitudinal sectional view showing another embodiment of the drug solution injector of the present invention.

FIG. 8 is a longitudinal sectional view showing another embodiment of the drug solution injector according to the present invention.

FIG. 9 is a cross-sectional view showing another example of the configuration of the airtightness maintaining means.

FIG. 10 is a cross-sectional side view showing another configuration example of the lock means in the present invention.

FIG. 11 is a cross-sectional side view showing another configuration example of the lock means in the present invention.

FIG. 12 is a perspective view of a lock unit according to the present invention.

FIG. 13 is a perspective view showing another configuration example of the state holding means in the present invention.

FIG. 14 is a perspective view showing another configuration example of the state holding means in the present invention.

FIG. 15 is a longitudinal sectional view showing another configuration example of the sealing means in the present invention.

FIG. 16 is a longitudinal sectional view showing another embodiment of the drug solution injector of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1A, 1B, 1C Chemical injection | pouring apparatus 2 Container main body 21 Port | mouth 22 Male screw 23 Flange 25 Space 3 Gasket 31 Projection 32 Depression 33 Hole 4 Plunger 41 Shaft part 42 Head part 43 Handle part 44 Flange 45 Pin 401 Hole 402 Lock Claw 403 Head 404 Depression 46 Flow path 5 Cap 51 Cap main body 52 Female screw 53 Sealing member 54 Guide surface 55 Plug 6 Locking means 61 Projection 62 Engaging member 63 Opening 64 Circular portion 65 Long hole portion 66 Projection 67 Opening 610 Link mechanism 611-614 Link 615-620 Bend 621, 622 Engaging claw 631, 634 Engaging claw 632, 633 Hole 7 Seal member 71 Opening 72 Outer peripheral surface 8 Holder 81 Holder body 811 Base end opening 82 Female screw 83 Double-ended needle 831 First needle tube 832 Second Tubes 833, 834 needle point 84 the hub 85 male thread 86 projecting portion 87 encapsulating member 9 chemical

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Shigeru Suzuki 1500 Inoguchi, Nakai-machi, Ashigara-gun, Kanagawa Prefecture Inside Terumo Corporation

Claims (17)

[Claims] 1. A cylindrical container main body having a mouth portion formed on a distal end side, a gasket slidable in a liquid-tight manner along an inner peripheral surface of the container main body, and a gasket connected to the gasket. A chemical liquid injector having a plunger that performs a sliding operation and a sealing unit that hermetically seals the opening, wherein a space surrounded by the container body and the gasket is in a reduced pressure state, A liquid injector is provided with locking means for preventing a gasket from moving in a direction in which the volume of the space decreases. 2. The liquid injector according to claim 1, wherein the sealing means includes a sealing member that can be pierced with a needle tube. 3. The liquid injector according to claim 2, wherein the sealing member is a membrane or a plug made of an elastic body. 4. The sealing means is provided on a cap body mounted around the mouth and on the cap body,
The liquid medicine injection device according to claim 1, further comprising a sealing member that is in close contact with an end surface of the mouth portion when the cap body is attached, and hermetically seals the mouth portion. 5. The liquid injector according to claim 4, wherein the cap body is detachably attached to the mouth. 6. The locking means comprises at least one projection formed on the plunger, and an engaging member mounted on a base end of the container body and engaged with the projection. Item 5. The drug solution injector according to any one of Items 1 to 4. 7. The locking device according to claim 6, wherein the locking means is configured to release the lock between the projection and the engaging member by rotating the plunger, thereby releasing the lock. Drug injection device. 8. The liquid injector according to claim 6, wherein the projection is formed by deforming the plunger. 9. The liquid injector according to claim 8, wherein the plunger has a link mechanism on a shaft thereof, and the link mechanism is deformed to form the protrusion. 10. The liquid injector according to claim 8, further comprising a state holding unit capable of holding at least one of a deformed state and a non-deformed state of the plunger. 11. The liquid injector according to claim 1, wherein the lock means can restrict the position of the gasket in the sliding direction to another stage. 12. The liquid injector according to any one of claims 1 to 11, wherein maintaining the reduced pressure in the space is performed by airtight holding means provided on a proximal end side of the gasket. 13. The liquid injector according to claim 12, wherein the airtight holding means has a flange formed on the plunger and located on a proximal end side of the gasket. 14. The liquid injector according to claim 12, wherein the airtight maintaining means is formed by a flange formed on the plunger and located on a proximal end side of the gasket, and a seal member closely contacting the flange. . 15. An airtight holding means for maintaining a reduced pressure state of the space, wherein the airtight holding means is formed on the plunger and is located at a base end side of the gasket; The drug solution injector according to any one of claims 6 to 11, comprising a sealing member that is in close contact with the joining member. 16. A container body having a bottomed cylindrical shape, a gasket slidable along the inner peripheral surface of the container body in a liquid-tight manner, a connecting member connected to the gasket and having a flow path therein, A chemical liquid injector having a sealing means for hermetically sealing one end of the flow channel, wherein a space surrounded by the container body and the gasket is in a reduced pressure state, and the space of the gasket is provided. A liquid injection device provided with locking means for preventing movement in a direction in which the volume of the liquid decreases. 17. The drug solution injector according to claim 1, wherein a drug is stored in the space.