JPH10218731A - Preparation for external use for skin treatment after depilation treatment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To offer the subject preparation capable of safely and quickly healing a skin lesion after depilation treatment by containing a specific ω 6-type unsaturated fatty acid. SOLUTION: This preparation is obtained by containing at least one kind selected from a group of γ-linolenic acid, dihomo-γ-linolenic acid and their derivatives. γ-Linolenic acid is obtained from filamentous cyanobacteriums such as Mortierela genus, Mucor genus and Rhizopus genus, or oils and fats contained in plants such as an evening primrose. The content of γ-linolenic acid in the medicine is 1 to 30wt.% (in terms of γ-linolenic acid in the case of dihomo-γ-linolenic acid or its derivatives).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin treatment after a hair removal treatment, and more particularly to an external preparation for a skin treatment which rapidly improves skin damage after the hair removal treatment.

[0002]

2. Description of the Related Art In recent years, hair loss has been one of the major changes in the field of beauty, and has now become a very large division of aesthetics.

[0003] Among the hair removal methods, the permanent hair removal method is the electric hair removal method. For example, by inserting a needle into the hair follicle and applying a direct current and / or a high-frequency current to the hair follicle through the needle, the hair is permanently depilated by heating and / or denaturing the hair mother cell. is there.

[0004] However, in the electric hair removal method, a burn due to high frequency heating and / or an alkali due to alkali denaturation causes an inflammatory condition, which damages the skin around the hair follicle and causes a red-spotted scar or rash on the skin surface. There's a problem.

[0005] In addition to the permanent hair removal method, there is a temporary hair removal method, for example, a method of shaving with a razor, removing with a hair remover, using a hair removal wax, using a hair removal cream, or the like. However, even in this temporary hair removal method, skin damage due to hair removal treatment is inevitable, for example, when shaving with a razor, skin roughening due to peeling of the skin surface, and hair removal or hair removal wax, a bumpy skin like goose bumps on the skin surface, furthermore Depilatory creams have the problem of causing skin irritation and the like due to chemicals such as alkaline agents.

[0006] Such a skin disorder after hair removal treatment is considered to be a kind of temporary acute inflammation, and it is important to improve it as soon as possible. If the inflammatory state is prolonged, in addition to the skin disorder, for example, hair due to bacterial infection Inconveniences such as cystitis, purulent inflammation, and pigmentation are likely to occur.

[0007] The skin disorder after the hair removal treatment is, for example, in the case of a person with an allergic disease typified by atopic constitution, a severe skin disorder appears as compared to a person with normal skin, or the skin condition is restored to the original state. Also takes a long time. Furthermore, not only in the temporary hair removal method but also in the permanent hair removal method, it is usually necessary to repeatedly treat the same part a few times in order to completely remove the hair, and more appropriate skin care after the hair removal treatment is required. I have.

[0008] As for the care of skin disorders that occur after the hair removal treatment, side effects have conventionally been concerned with steroidal anti-inflammatory drugs. For example, even non-steroidal anti-inflammatory drugs have a weak effect such as glycyrrhizin or moisturizing. Cream containing a plant extract such as aloe as an agent, application of lotions, and methods such as cooling of the hair removal treatment site with a cooled water-containing towel have been performed, but it is difficult to quickly improve the skin, At present, there is no satisfactory treatment method for a skin disorder that occurs after the hair removal treatment, and the situation is left to natural healing.

[0009] As described above, in hair removal, it is required to perform appropriate skin treatment for returning the skin disorder caused by the hair removal treatment to the original skin state as quickly as possible, and there is no inconvenience such as side effects. Is desired.

[0010]

SUMMARY OF THE INVENTION Accordingly, the present invention has been made from the above viewpoint, and an object of the present invention is to provide an external preparation for skin treatment after depilatory treatment which safely and promptly improves skin damage caused after depilatory treatment. And

[0011]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, a specific ω6
The inventors of the present invention have found that a systemic unsaturated fatty acid can provide good results for skin disorders after hair removal treatment, and have accomplished the present invention.

That is, the present invention provides a γ-linolenic acid,
The present invention relates to an external preparation for skin treatment after depilatory treatment, comprising one or more selected from dihomo-γ-linolenic acid and derivatives thereof.

[0013]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. Γ-linolenic acid as an active ingredient used in the present invention,
Dihomo-γ-linolenic acid (these and their derivatives
Hereinafter, it may be referred to as “γ-linolenic acid or the like”)
Endogenous unsaturated fatty acids known as essential fatty acids in the system. It is considered that the ω6-based fatty acid is converted in vivo by the following pathway. Fatty acids of this series are thought to play a very important role in maintaining normal skin, and today, γ-linolenic acid and the like are merely precursors of one series of prostaglandins. Not only for these reasons, but also their unique physiological effects are attracting attention.

[0014] It is not always clear why the external preparation for skin treatment after depilatory treatment of the present invention rapidly improves skin disorders caused by depilatory treatment. Against disorders such as γ-linolenic acid and a series of prostaglandins, such as prostaglandin E ₁ (PGE ₁ )
Via a cAMP (cyclic AMP) production was inhibited acute inflammation, also thought that it is the order PGE ₁ is effectively contribute to the hyperplasia of collagen fibers precious dermis for skin repair. In addition, since γ-linolenic acid and the like are endogenous substances, they have good affinity with the skin, and provide good results in use feeling and safety.

[0015] Natural sources of γ-linolenic acid and the like are limited, and Mortierella is usually used.
la) genus, Mucor genus, Rhizopus (Rh)
It is obtained from filamentous fungi of the genus Izopus, or plants such as evening primrose and borage, and also from oils and fats contained in algae such as spirulina. Is also good. Also, γ
-Linolenic acid or the like can also be obtained by chemical synthesis,
A commercially available product may be used.

The derivatives of γ-linolenic acid or dihomo-γ-linolenic acid include esters obtained by reacting these with various alcohols, for example, ethyl esters, glycerol esters, phospholipids, etc .; And a salt obtained by acting the compound in an equimolar ratio, for example, a sodium salt, a potassium salt and the like.

The external preparation for skin treatment after depilatory treatment of the present invention may be one or a mixture of two or more selected from γ-linolenic acid, dihomo-γ-linolenic acid and derivatives thereof, or the above-mentioned filamentous fungi, plants and the like. Extracts obtained from fats and oils, generally harmless kind of pharmaceutically acceptable,
Alternatively, it is mixed with several kinds of vehicles, carriers, excipients, integrating agents, preservatives, stabilizers, fragrances, coloring agents, etc., for external use such as liquid, emulsion, cream, gel, jelly, paste, etc. And, if necessary, cataplasms and plasters, which can be produced using conventionally known techniques.

As described above, the dosage form of the external preparation for skin treatment of the present invention is not particularly limited. However, it is important that absorption from the skin and simplicity of production and that, if necessary, massaging after application are performed. Considering the oil liquid (oil)
It is preferred to be in the form. As an example of such a formulation, a combination example of γ-linolenic acid-containing fats and oils and vitamin E was given in the examples described later, but this oil liquid formulation has no stickiness and is excellent in safety and usability. Things.

The external preparation of the present invention includes oils and fats such as sesame oil, soybean oil and olive oil, α-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, myristooleic acid, palmitooleic acid, oleic acid and erucic acid. Fatty acids such as glycerol, lauric acid and myristic acid; antioxidants such as vitamin E and its derivatives, γ-oryzanol; humectants such as glycerin, polyethylene glycol and propylene glycol; local anti-inflammatory and antipruritic agents such as methyl salicylate; One or two or more of these may be used. Among them, vitamin E and its derivatives are preferably used. Vitamin E is considered to contribute to the maintenance of a normal membrane function while preventing the oxidation of γ-linolenic acid and the like by its antioxidant action in addition to the above-mentioned reason.

The content of γ-linolenic acid in the external preparation for skin treatment after depilatory treatment is not particularly limited (the content of dihomo-γ-linolenic acid and each derivative is converted to the amount of γ-linolenic acid). If the amount is too small, the effect of treating the skin disorder will not be sufficiently obtained, and if the amount is too large, it will be economically expensive. Therefore, it is usually used in the range of 1 to 30% by weight.

The method for using the external preparation for skin treatment of the present invention thus obtained may be applied to the treatment site immediately after the hair removal treatment and spread lightly. Moreover, you may make it apply | coat to a process part beforehand before a hair removal process.

[0022]

EXAMPLES Examples using the external preparation for skin treatment after depilatory treatment of the present invention will be described below, but the scope of the present invention is not limited to these examples.

<Production method of external preparation> Mortierella (Mor
gamma-linolenic acid-containing oils and fats extracted from cells of the genus tierella) (trade name: GLARO, manufactured by Idemitsu Materials Co., Ltd.)
08, containing about 8% by weight of γ-linolenic acid) 1 part by weight;
Vitamin E (trade name: EMIX manufactured by Eisai Co., Ltd.)
80) 1 part by weight was mixed and stirred to produce an external preparation for skin treatment after depilatory treatment according to the present invention.

<Usage Test> In order to clarify the effect of the external preparation for skin treatment of the present invention, a use test in the electric hair removal method was performed using the external preparation of the present invention obtained by the above-mentioned production method.

(1) Method 16 subjects (18-4
A 2-year-old woman) was randomly selected, and group A (8
) And Group B (8 persons). The external preparation for skin treatment of the present invention was applied to Group A immediately after the hair removal treatment, and Group B was left untreated after the hair removal treatment and left to natural healing. Next, the skin condition of the depilation treatment site immediately after the depilation treatment and one day after the depilation treatment was visually compared, and the improvement rate was determined by the following evaluation. Table 1 shows the results.

(2) Evaluation +++: Almost all skin damage due to hair removal treatment is recovered. Hair damage worsens skin damage

[0027] The improvement rate refers to a ratio indicating ++ or +++, and indicates that the skin has recovered to a level that is not bothersome even when the skin is exposed. From the above results, the group A treated with the external preparation for skin treatment after the hair removal treatment according to the present invention, compared to the untreated group B,
It can be seen that the skin disorder after the hair removal treatment was quickly improved. In addition, three of the five subjects in the +++ evaluation of the group A had an improvement effect within 3 hours after the treatment. On the other hand, seven subjects in one evaluation of group B received ten evaluations, five after two days and two after five days. In addition, no side effect was observed at all in the group A 8 patients due to the use of the external preparation for skin treatment of the present invention.

The feeling of use of the external preparation for skin treatment of the present invention for 8 subjects in Group A is as follows.
Table 2 summarizes the results of an investigation on the skin condition after use and the stickiness during use.

[0029] As is clear from the above results, the skin treatment external preparation after depilatory treatment according to the present invention rapidly improves skin disorders after depilatory treatment, has no problem in safety, and is excellent in usability. You can see that.

[0030]

EFFECT OF THE INVENTION The external preparation for skin treatment after depilatory treatment of the present invention has an effect of improving the skin immediately after application against skin disorders occurring after the depilatory treatment, and also has excellent safety and usability. I have.

 ──────────────────────────────────────────────────の Continuation of the front page (72) Inventor Naoko Sugada 5-6-1 Shiba, Minato-ku, Tokyo

Claims (1)

[Claims] 1. An external preparation for skin treatment after depilatory treatment, comprising one or more selected from γ-linolenic acid, dihomo-γ-linolenic acid and derivatives thereof.