JPH10203933A - Hair-restoring and growing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair-restoring and -growing agent that can manifest the increased hair-restoring and -growing effects and depilation prevention with high safety for a long period of time synergistically by using an extract of a plant, Engelhardtia chrysolepis H. and a specific medicine in combination. SOLUTION: This hair-restoring and -growing agent comprises a combination of (a) 0.001-50wt.% of an extract of Engelhardtia chrysolepis H. and (b) 0.0001-30wt.% of a transdermal absorption accelerator. The component b is preferably a phospholipid or cyclodextrin. In addition, the following components may be admixed this agent: circulation accelerator, keratolytic agent, antiseborrheic drug, local irritant, anti-inflammatory, moisturizer, antiandrogen, follicle activator and potassium channel opener.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair-growing / hair-growing agent, and more particularly, to a hair-growing / hair-growing agent having excellent hair-growing / hair-growing action and hair loss-preventing action and having high safety.

[0002]

2. Description of the Related Art
Synthetic drugs or natural product extracts having various effects are used in pharmaceuticals or cosmeceuticals for the purpose of hair growth and hair growth, but none of these can provide sufficient effects with the addition of small amounts. On the other hand, when added in a large amount, it has a disadvantage that it gives an unpleasant irritating sensation to the site of application, and further continued use causes dermatitis.

[0003] Further, the above-mentioned hair growth and hair growth products do not directly act on the differentiation and proliferation of the hair matrix, but rely on an indirect action through normalization of the condition of the scalp, Enough hair nourishment for human hair
It did not show a hair growth effect.

[0004] Therefore, as a hair-growing / hair-growing agent having a hair-growing / hair-growing action and a hair-growth-preventing effect by directly acting on the differentiation and proliferation of hair mother cells, there has been proposed a hair growth / hair-growing agent containing an extract of Huangkai. (JP-A-8-73325). However, there has been a demand for a hair-growth / hair-growth material with even higher effects.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies in view of the above-mentioned circumstances, and as a result, if a yellow ginkgo extract and a percutaneous absorption enhancer are used in combination, the synergistic effects of these extracts will be obtained.
The present inventors have found that a hair-growing / hair-growing agent having a higher hair-growing / hair-growing effect and a hair loss-preventing effect and having high safety over a long period of time can be obtained, and have completed the present invention.

That is, the present invention provides:
And (b) a hair restoration / hair restoration material characterized by containing a percutaneous absorption enhancer.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION
elhardtia chrysolespis H .; )
Is a plant of the walnut family, and the yellow extract is dried or ground without drying, and then extracted with a solvent at room temperature or under heating, or an extraction device such as a Soxhlet extractor. And can be obtained by extraction.

Here, the solvent used is water or methanol, ethanol, propanol, butanol,
Alcohols such as ethylene glycol, propanediol, butanediol, and glycerin and hydrates thereof are used, and acetone, ethyl methyl ketone, chloroform, methylene chloride, ethyl acetate and hydrates thereof may be used. The extract may be concentrated by evaporation of the solvent, if necessary, and may be used as it is after concentration adjustment, or may be treated with activated carbon to prevent decolorization, removal of insolubles, and formation of sediment.
The resin may be used after being subjected to a treatment such as resin treatment, filtration, or removal of insoluble matter left at low temperature.

The extract may be used as it is, but the extract may be further purified by a suitable separation means such as gel filtration, silica gel column chromatography, or reversed-phase or normal-phase high-performance liquid chromatography. Fractions can be fractionated and used.

[0010] The yellowish extract thus obtained is usually preferably used after being dissolved in water or a solvent such as water-lower alcohol. From the viewpoint of irritation to the scalp, etc., the yellowish extract of the component (a) has a dry weight of 0.00 in the total composition.
1 to 50% by weight, especially 0.01 to 20% by weight, more preferably 0.1 to 20%
It is preferred that the content is from 0.01 to 10% by weight.

The percutaneous absorption enhancer of the component (b) used in the present invention is not particularly limited as long as it is generally used for promoting percutaneous absorption. For example, phospholipid, cyclodextrin, oleyl Alcohol, ethyl-2-hydroxypropanoate, acetone, propan-1-ol, butyl laurate, dimethyl sulfoxide, 2-pyrrolidone, urea, butane-1,4-diol, octyl alcohol, lauryl alcohol, myristic acid, propane -2-ol, 2-methylpropane-
2-ol, hexane-2,5-diol, pentane-
2,4-diol, polyoxyethylene (2) methyl ether, polyoxyethylene (2) ethyl ether, polyoxypropylene (15) stearyl ether, di (2-hydroxypropyl) ether, 2-hydroxypropionic acid, 2- Hydroxyoctanoic acid, 2-hydroxypropanoic acid, 1,4-dioxin, tetrahydrofuran, propylene glycol diperargonate, 2-ethyl-hexylperargonate, dioctyl adipate, dicapryl adipate, diisopropyl adipate, diisopropyl sebacate, dibutyl sebacate,
Diethyl sebacate, dimethyl sebacate, dioctyl sebacate, dibenzyl sebacate, dibutyl suberate, dimethyl azelate, dioctyl azelate, dibutyl azelate, dibutyl phthalate, didecyl phthalate, ethyl myristate, butyl myristate, dibutyls Succinate, decyl oleate, ethyl caproate, ethyl laurate, ethyl satylate, isopropyl palmitate, butyl stearate, isopropyl isostearate, butyl stearate, benzyl benzoate, butyl benzoate, hexyl laurate,
Ethyl caprate, ethyl caprylate, benzyl salicylate, N, N-dimethylacetamide, N, N-dimethylformamide, 1-methyl-2-pyrrolidone, 5
-Methyl-2-pyrrolidone, 1,5-dimethyl-2-pyrrolidone, 1-ethyl-2-pyrrolidone, phosphine oxide, sugar ester, tetrahydrofurfuryl alcohol, diethyl-m-toluamide, 1-dodecylazacycloheptane-2 -On and the like. Further, a plant extract containing a component having a transdermal absorption promoting effect may be used,
For example, a plant extract such as peppermint or bursaria can be used.

Of these, phospholipids or cyclodextrins are particularly preferred. Specifically, examples of phospholipids include phosphatidylglycerol, phosphatidylcholine, sphingomyelin, liposomes, and the like. Examples of cyclodextrins include, for example, 2-hydroxypropylated-β-cyclodextrin and dimethylated- β-cyclodextrin and the like.

The percutaneous absorption enhancer of component (b) can be used alone or in combination of two or more, and is preferably incorporated in the total composition in an amount of 0.0001 to 30% by weight, particularly preferably 0.1 to 30% by weight. 001 to 20% by weight, further 0.001 to 10% by weight
It is preferable to mix them.

The hair-growing / hair-growing composition of the present invention may further comprise (c) a blood circulation promoting agent, an antibacterial agent, a keratolytic agent, an antiseborrheic agent, a local stimulant, an anti-inflammatory agent, A humectant, an antiandrogen, a hair follicle activator, a potassium channel opener and the like can be added. These do not act directly on the hair, but have an action different from that of the Huangkai extract, so that the hair restoration action is more strongly expressed when used in combination. For example, blood circulation enhancers indirectly grow hair by promoting nutrient replenishment and transport of metabolites from hair mother cells, and antimicrobial agents by inhibiting the action of bacteria on the scalp. Is to encourage.

Among these components, examples of the blood circulation promoting agent include nicotinamide, benzyl nicotinate, acetylcholine, assembly extract, carrot extract, ginkgo extract, carpronium chloride, diphenhydramine hydrochloride, γ-oryzanol, circretin, cromakalim, cepharanthin And nicorandil, vitamin E, vitamin E derivatives such as vitamin E nicotinate, pinacidil, minoxidil, phthalides, kina extract, shobu root extract, spruce extract, medicinal herb extract, yuzu extract and the like. Among them, acetylcholine, assembly extract, carrot extract, ginkgo extract, vitamin E and its derivatives, cepharanthin, minoxidil, carpronium chloride, diphenhydramine hydrochloride, γ-oryzanol, circretin, cromakalim, cepharanthin, nicorandil, pinacidil, minoxidil, phthalides,
A kina extract, a shobu root extract, a spruce extract, a medicinal herb extract and a yuzu extract are preferred, and a particularly preferred are assembly extract, carrot extract, ginkgo extract, vitamin E and its derivatives, cepharanthin, minoxidil, carpronium chloride and phthalides.

Examples of the antibacterial agent include isopropylmethylphenol, benzalkonium chloride, octopirox, photosensitive dye 101, photosensitive dye 201, chlorhexidine, salicylic acid, zinc pyrithione, potassium sorbate, biosol, hinokitiol, and phenol. Of these, octopirox, benzalkonium chloride, zinc pyrithione, salicylic acid and isopropylmethylphenol are preferred.

Examples of the keratolytic agent include aspirin and the like. Antiseborrheic agents include sulfur, thioxolone, banside, polysorbates, lecithin, cashew extract and the like. As a local stimulant, camphor,
Pepper tincture, nonylate varnish, l-menthol, ginger tincture, Dutch pepper extract,
Cantharis tincture, salmon extract, peppermint oil, wasabi radish extract and the like.

Examples of anti-inflammatory agents include licorice extract, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, fat-soluble glycyrrhetinic acids, azulene, guaiazulene, antihistamines (such as diphenhydramine),
Hydrocortisone Acetate, Prednisolone, Ogon Extract, Chamomile Extract, Kawamurai Extract, Kikyo Extract, Kyowinin Extract, Gardenia Extract, Kumasasa Extract, Gentian Extract, Comfrey Extract, Hawthorn Extract, Birch Extract, Achillea Millefolium Extract,
Gentle oil extract, Tonin extract, peach leaf extract, loquat leaf extract and the like. Among them, β-glycyrrhetinic acid, dipotassium glycyrrhizinate, chamomile extract,
Achillea millefolium extract is preferred.

Examples of humectants include Hypericum extract, oat extract, sorbitol, soluble collagen, glycerin, chondroitin sulfate, tuberose polysaccharide, cordyceps, trisaccharide, urea, biohyaluronic acid, hyaluronic acid, calcium calcium vitamin C phosphate. , Sodium pyrrolidone carboxylate, propylene glycol, prolonged life grass extract, barley extract,
Orange extract, seaweed extract, cucumber extract,
Burdock extract, shiitake mushroom extract, Jiaogu extract, Duke extract, loquat extract, grape leaf extract, prune extract, loofah extract, Maikai extract, mini sasanishiki,
Lily extract, apple extract and the like can be mentioned.

Examples of antiandrogens include cyproterone acetate, 11α-hydroxyprogesterone,
Examples include flutamide, 3-deoxyadenosine, chlormadinone acetate, ethinylestradiol, spironolactone, epitestosterone, aloe, sansho, and panax ginseng.

As the hair follicle activator, N-acetyl-L-
Methionine, disodium adenosine triphosphate, potassium aspartate, photosensitive dye 301, pentadecanoic acid glyceride, netacanal, ethyl pantothenate, panthenol, biotin, mononitroguaiacol sodium, yeast extract, pearl protein extract, daisy extract, chik Ginseng, garlic components, placenta extract, royal jelly extract and the like.

As the potassium channel opener,
Minoxidil, cromakalim, diazoxide, pinacidil and the like.

The above component (c) is preferably used singly or as a mixture of two or more types, and is preferably used after being dissolved in water or a solvent such as water-lower alcohol.

Component (c) is contained in the total composition in an amount of 0.001 from the viewpoint of synergistic effect with component (a) and irritation to the scalp.
-5% by weight, especially 0.01-3% by weight.

The hair-growing / hair-growing agent of the present invention is not limited in its form as long as it can be applied to the hair and scalp, but it is preferably an effective-applied form. Usually, it is mainly a liquid, lotion or hair tonic. Are typical, but creams, gels, shampoos, rinses, hair foams, hair sprays and the like can also be used. Liquids include carbon dioxide, L
PG, DME, nitrogen and the like can be used as a propellant, and it is particularly preferable to contain carbon dioxide gas. Carbon dioxide gas is known to be present as CO ₂ molecules when the solution in which it is dissolved has an acidic pH, and exhibit a vasodilatory effect. Therefore, it is preferable that the liquid properties of the hair growth and fostering composition of the present invention containing carbon dioxide be adjusted to pH 7 or less, particularly pH 4.5 to 6.5. It should be noted that the pH of the hair-growing / hair-growing agent is further increased by injecting carbon dioxide gas into the hair-growing / hair-growing material, and the final pH may be adjusted to fall within the above range. As the pH adjuster, for example, organic acids such as citric acid, tartaric acid, and lactic acid or salts thereof, or phosphoric acid or salts thereof are suitably used.

In order to incorporate carbon dioxide into the hair growth and fostering material of the present invention, other components than carbon dioxide are put into a pressure-resistant container, and high-pressure carbon dioxide gas is sealed therein. A method of adding a component that generates carbon dioxide gas containing carbonate and adding a pH adjusting agent to the mixture to generate carbon dioxide gas and sealing immediately, or a method of sealing by placing dry ice pellets in a container, etc. Although it is adopted, a method of sealing high-pressure carbon dioxide gas is particularly preferable.

At this time, a part of the carbon dioxide gas is dissolved and blended in the hair growth and fostering material of the present invention, and a part thereof is present as a gas in the container. In the present invention, it is important that the carbon dioxide gas is dissolved and compounded in the hair growth and hair growth material, and the compounding amount is preferably a carbon dioxide gas concentration of 60 ppm or more. Cannot be obtained. The amount of carbon dioxide gas can be adjusted by adjusting the amount of carbon dioxide gas injected (press-fitted). In general, the pressure in the vessel is 35 ° C. and 1.2 to 8 kg / cm ^2.
(Gauge pressure).

In addition to the above-mentioned components, the hair-growing / hair-growing agent of the present invention may contain, if necessary, an oily base, a gelling agent, and various oils used in ordinary cosmetics as long as the effects of the present invention are not impaired. An emulsifier, a fragrance, an antioxidant such as parahydroxybenzoate, a coloring agent such as a dye, and the like can be added and blended.

The hair-growing / hair-growing agent of the present invention can be produced by subjecting the above essential components and optional components to operations such as mixing according to a conventional method.

[0030]

EFFECTS OF THE INVENTION The hair-growing / hair-growing agent of the present invention has a high hair-growing / hair-growing action and a hair loss-preventing action by the synergistic effect of the extract of Huang Gui and a phospholipid or cyclodextrin, and is effective for a long period of time. It has high security.

[0031]

EXAMPLES The present invention will be specifically described below with reference to examples, but the present invention is not limited to these examples.

Production Example 1 A ground yellow leaf (10 kg) was stirred in 80% by weight ethanol at 40-60 ° C. and filtered. The filtrate was concentrated under reduced pressure to obtain 20 liters of a concentrate, to which ethanol was added.
The ethanol concentration was adjusted to 50% by weight. After leaving it at low temperature, it was filtered. 36 kg of yellowish extract (2.1% by weight of dry solid content) was obtained as a filtrate.

Production Example 2 In Preparation Example 1, instead of adding ethanol to the concentrated solution to adjust the ethanol concentration to 50% by weight, 1,3-butylene glycol was added to adjust the 1,3-butylene glycol concentration to 50% by weight. Except for the following, the same procedure as in Production Example 1 was carried out to obtain 34 kg of a yellowish extract (dry solid content: 2.1% by weight).

Production Example 3 In the same manner as in Production Example 1, except that the ethanol concentration was adjusted to 50% by weight, 500 g of activated carbon was added, and the mixture was stirred and filtered. 34 kg (1.8% by weight) were obtained.

Production Example 4 In Production Example 2, the concentration of 1,3-butylene glycol was adjusted to 5
After adjusting to 0% by weight, 500 kg of activated carbon was added, and the mixture was stirred and filtered in the same manner as in Production Example 2, except that filtration was performed, to obtain 33 kg of yellowish extract (1.8% by dry solid content).

Example 1 A hair restoration / hair restoration (lotion) having the following composition was produced by a conventional method.

[0037]

(Table 1) (Ingredients) (% by weight) Yellow myth extract (Preparation example 1) 2.00 Phosphatidylcholine 0.05 Carrot extract 0.50 Pepper tincture 0.05 Glycerin 0.15 Ethanol 50.00 Purified water Appropriate amount

Example 2 A hair restorer / hair restorer (lotion) having the following composition was produced by a conventional method.

[0039]

(Ingredients) (% by weight) Yellow extract (Preparation Example 1) 2.00 Dimethylated-β-cyclodextrin 1.00 Cepharanthin 0.002 Pepper tincture 0.05 Propylene glycol 0.20 Ethanol 50. 00 Appropriate amount of purified water

Example 3 A hair restorer / hair restorer (gel) having the following composition was produced by a conventional method.

[0041]

(Ingredients) (% by weight) Yellow ginger extract (Preparation Example 3) 2.00 1-menthol 0.30 Dimethylated-β-cyclodextrin 1.00 Dipotassium glycyrrhizinate 0.08 Pepper tincture 0.05 Carboxyvinyl polymer (Carbopol 940, manufactured by BF Goodrich) 0.30 Sodium hydroxide proper amount Ethanol 30.00 purified water proper amount

Example 4 A hair restorer / hair restorer (shampoo) having the following composition was produced by a conventional method.

[0043]

[Table 4] (Components) (% by weight) Yellowish extract (Preparation Example 3) 2.00 Liposomes 2.00 1-Menthol 1.00 Polyoxyethylene lauryl ether 22.00 Cationic polymer (Polymer JR400, Union Carbide) 0.25 Ethanol 10.00 Purified water qs perfume trace amount pH adjuster qs

Example 5 A hair restoration / hair restoration (lotion) having the following composition was produced by a conventional method.

[0045]

(Table 5) (Ingredients) (% by weight) Yellow ginger extract (Preparation example 2) 2.00 Dimethyl sulfoxide 0.03 Cepharanthin 0.00 Camphor 0.05 Diou extract 0.50 Ethanol 50.00 Purified water Appropriate amount

Example 6 A hair restorer / hair restorer (lotion) having the following composition was produced by a conventional method.

[0047]

(Ingredients) (% by weight) Yellow ginger extract (Production Example 2) 2.00 Octyl alcohol 5.00 Polyoxyethylene (25EO) hydrogenated castor oil 0.25 dl-α-tocopherol acetate 0.05 Capsicum Tincture 0.05 ethanol 50.00 purified water qs

Example 7 A hair restorer / hair restorer (lotion) having the following composition was produced by a conventional method.

[0049]

[Table 7] (Components) (% by weight) Yellow ginger extract (Production Example 1) 2.00 l-menthol 0.10 Sensou extract 0.50 Assembly extract 1.00 Carrot extract 0.50 Ethanol 50.00 Purified water qs

The hair restoration and hair restoration materials obtained in Examples 1 to 7
All had excellent hair-growth / hair-growth effects and hair loss prevention effects, and were also highly safe.

Example 8 A hair growth / hair growth material having the composition shown in Table 8 was produced by a conventional method, and its hair growth promotion effect was evaluated. That is, 49
The back hair of day-old C3H / HeNCrj mice (20 mice per group) was shaved over 2 × 4 cm ² using an electric clipper and an electric shaver so as not to damage the skin. Then
From the next day, the hair growth / hair restoration was applied once a day (20 μl). After the application, the ratio of the regenerated hair area on the 18th day (regenerated hair area / shaved area) was measured. The results are shown in Table 8 as average values.

[0052]

[Table 8]

As is clear from the results shown in Table 8, the product of the present invention exhibited a superior and remarkable hair regeneration (promoting hair growth) effect as compared with the comparative product. The mice to which the product of the present invention was applied were all healthy and had no effect on the skin.

Claims (4)

[Claims] 1. A hair restorer / hair restorer comprising (a) a yellow extract and (b) a percutaneous absorption enhancer. 2. The hair restorer / hair restorer according to claim 1, wherein (b) the transdermal absorption enhancer is a phospholipid or a cyclodextrin. (C) a blood circulation promoting agent, an antibacterial agent, a keratolytic agent, an antiseborrheic agent, a local stimulant, an anti-inflammatory agent, a humectant, an antiandrogen, a hair follicle activator, and a potassium channel opener. The hair restoration / hair restoration according to claim 1 or 2, comprising a component selected from the group consisting of: 4. Component (a) is added in an amount of 0.001 to 50% by weight,
The hair restoration / hair restoration material according to any one of claims 1 to 3, which contains 0.0001 to 30% by weight of the component (b).