JPH10175868A - Water (of chinese medicine idea) improving composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition capable of stimulating organs con trolling the secretion of water to the outside of the body, promoting and improv ing water (of Chinese medicine idea) action for promoting the secretion of water in the body to the outside of the body, comprising a saccharide and a lipid having bio-compatibility. SOLUTION: This composition comprises (A) a saccharide, preferably one or more selected from glucose, galactose, fructose, mannitol, sorbitol, trehalose, saccharose, arabinose, ribose, deoxyribose, rhamnose and glycerol and (B) a lipid having bio-compatibility, preferably one or more selected from the group consisting of phospholipid, sphingophospholipid and sphingoglycolipid. Preferably, the composition comprises 0.01-50 wt.% of the component A and 0.05-10 wt.% of the component B in the weight ratio of the component A: the component B of 1:9 to 9:1.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for improving a tanning solution, such as a cosmetic, a bath preparation, and a medicine for external use on the skin, which is useful for improving the effect of a tanning solution.

[0002]

2. Description of the Related Art The concept of qi, blood, and water in Chinese medicine has long been studied because of its uniqueness in understanding its pharmacological action and a rational index for selecting Chinese medicine. Of these, many have been elucidated about the meanings of qi and blood. For example, it is known that blood is a keyword that represents the supply and metabolism mainly of energy such as oxygen and nutrition, and ki is a keyword that represents the status of the homeostasis of life activity and the status of the driving force of life activity. Have been.

[0003] However, only the metabolism and excretion of waste products is known for the function of water (tsu liquor).
Since the recognition was delayed in the logical form of water, the elucidation of its true action (Tsukumi action) was incomplete. Also, little is known about the relationship between the pulp action and the various pharmacological actions recognized in modern medicine, and the role of pulp in modern medicine. There has been a demand for the development of compositions such as cosmetics and pharmaceuticals that bring about the following.

[0004]

DISCLOSURE OF THE INVENTION The present invention has been made in view of such circumstances, and clarifies the true function of a tsuju. The task is to provide

[0005]

Means for Solving the Problems In view of such a situation, the present inventors have conducted intensive studies in search of the true function of tsuju. It was found that it stimulates the organs responsible for extracorporeal secretion and promotes the secretion of body water out of the body. Then, as a result of examining substances capable of stimulating such secretory organs and promoting / improving the action of the pulp, the present invention was completed.

[0006] That is, the present invention provides a tsunami-improving composition which comprises a saccharide and a biocompatible lipid as active ingredients and which is used for improving the effect of tsunami. Also, the present invention
An object of the present invention is to provide a composition for treating or preventing a skin disease, comprising a saccharide and a biocompatible lipid as active ingredients.

[0007] The present inventors have found that the essence of the tanning solution, which promotes the secretion of water from the dermis to the epidermis and causes the epidermis to retain sufficient moisture, atopic dermatitis, eczema,
Dermatomycosis, warts, pigmentation, psoriasis vulgaris, senile xeroderma, senile keratoma, therapeutic effects on various skin diseases such as burns,
It has been found that the action is related to a hair growth promoting action, a sweat promoting action, a digestive juice secretion promoting action, a diuretic action and a bowel movement promoting action caused by promoting water secretion in the stomach wall, kidney and intestinal tract.

[0008] That is, the medicinal classification of Chinese herbal medicines was examined in detail, and compared with modern medicine classifications.
It is said that the effects of the herbs such as shampoo, irrigation, conduction and prosthesis are related to beautiful skin effect, atopic dermatitis treatment, and dermatitis group treatment represented by eczema in the modern pharmaceutical classification. , Dermatomycosis treatment, wart treatment, pigmentation such as hepatitis, psoriasis vulgaris, senile xeroderma, senile keratoma treatment, skin damage treatment due to physical causes It has been found that it is closely related to the action, the hair growth promoting action, the digestive juice secretion promoting action, the sweating promoting action, the diuretic action and the bowel movement promoting action.

Based on this finding, screening was carried out on various substances based on their beautifying effect, therapeutic effect on atopic dermatitis, promoting hair growth, treating eczema, promoting secretion of digestive juice, and promoting sweating. , Glucose, galactose, fructose, mannitol, sorbitol,
It has been found that a composition in which a saccharide such as trehalose, saccharose, arabinose, ribose, deoxyribose, rhamnose, and glycerin is combined with a biocompatible lipid such as phospholipid, sphingolipid, and glycosphingolipid is excellent in such action. Was. In addition, topical administration of these compositions to the skin may cause the above-mentioned diseases caused by insufficiency of tsuchu,
In particular, they have found that they are effective in treating and preventing skin diseases such as atopic dermatitis, and have completed the present invention.

[0010] It has never been known that a composition comprising a combination of a saccharide such as glucose and a biocompatible lipid such as a phospholipid is excellent in the effect of improving the pulp action. Also, it was not known at all that, for example, an effect of remarkably improving various skin diseases such as atopic dermatitis was obtained.

[0011]

Embodiments of the present invention will be described below. The tsutsumo improvement composition of the present invention is characterized by containing a saccharide and a biocompatible lipid as active ingredients. Here, the saccharide may be a generally known saccharide,
For example, glucose, galactose, fructose, arabinose, 3-6 carbon sugars such as ribose and derivatives thereof, specifically, mannitol, sorbitol, sugar alcohols such as glycerin, deoxyribose, deoxy sugars such as rhamnose, glucosamine and the like. Monosaccharides containing carboxyl group-containing sugars such as amino sugars and glucuronic acid and gluconic acid, and polysaccharides such as trehalose and saccharose composed of one or more dehydrated conjugates thereof can be preferably exemplified. Among them, glucose, galactose, fructose, mannitol, sorbitol, trehalose, saccharose, arabinose, ribose, deoxyribose, rhamnose,
It is preferable to use one or more monosaccharides or polysaccharides having a polymerization degree of 2 to 3 selected from the group consisting of glycerol and glycerin. In the composition of the present invention, the saccharide has an effect of improving the essence of the juice. The preferred saccharide content in the tsukumo improvement composition of the present invention is 0.01 to 50 with respect to the total amount of the composition.
%, More preferably 0.1 to 30% by weight, even more preferably 0.5 to 20% by weight.

The biocompatible lipid in the present invention refers to a lipid existing between cells or in nerve cells, and has an affinity for living cells. Examples of such a biocompatible lipid include phospholipids, phosphosphingolipids, and glycosphingolipids. Phospholipids include lecithin, phosphatidylserine, phosphatidylinositol,
Preferred examples include lysophospholipids such as phosphatidylethanolamine, phosphatidylglycerol, phosphatidic acid, and lysolecithin. Preferred examples of glycosphingolipids include cerebroside, ganglioside, and the like, in which sphingosine, sugar, and a fatty acid are bound.
Preferable examples of the sphingophospholipid include sphingomyelin, which is a conjugate of sphingosine, phosphoric acid, and a fatty acid. These biocompatible lipids may be used alone or in combination of two or more. It is also possible to use a biological substance such as a brain extract as a mixture. Many of these are already commercially available, and it is also possible to use them. In the composition of the present invention, it is considered that the biocompatible lipid plays a role in assisting the sugar to migrate into the dermis, which is a place for improving the pulp juice, and to exert the effect of improving the pulp juice action. The preferred content of the biocompatible lipid in the composition of the present invention is
0.01 to 20% by weight, more preferably 0.05 to 20% by weight.
10 to 10% by weight, more preferably 0.1 to 5% by weight
It is.

[0013] The composition of the present invention has an excellent effect on the improvement of the essence by combining the above saccharide and a biocompatible lipid. The ratio of the saccharide to the biocompatible lipid in the composition is preferably 1: 9 to 9:
1, more preferably 1: 3 to 3: 1.

In the composition of the present invention, in addition to the above-mentioned essential sugars and biocompatible lipids, it is usually used in preparations in which the composition of the present invention can be applied, such as cosmetics, bath preparations, and external dermatological drugs. Various optional components can be contained. Such optional components include, for example, hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and gay wax, tallow, triglycerides such as olive oil, cetanol,
Higher alcohols such as oleyl alcohol, fatty acids such as stearic acid and oleic acid, polyhydric alcohols such as diglycerin and 1,3-butanediol, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric Examples include surfactants, thickeners such as ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants, pigments, and powders. Such a preparation can be produced according to a commonly used method.

[0015] The composition of the present invention thus obtained is used for improving the essence of Tsutsumi. Preferably, it is used as a cosmetic, a bath preparation or a skin external medicine. Further, the composition of the present invention can be preferably a composition for treating or preventing skin diseases.

It is known that the tsuju action is expressed in a living body as a mode of expression, such as a shampooing action, a water-saving action, a prosthesis action, and a conduction action. As a herbal medicine having these effects, if it is a depressant effect, rhubarb, banshayou, rokai, machinin, kengoshi, kansui, genka,
Zokuzi-ishi, kyukyu-compi, and the like are known, and as herbal crude drugs having a water-utilizing effect, chorei, bukuro,
Taksha, chinko, yokuinin, toucanin, difushi, tokhihi, calendula, etc. are known, and as herbal crude drugs having a prominence action, shajin, seijin, tenmondou, bakkumondou, sekikoku, goktyku, zyaku, sukiyase, kanrensou, jyoseishi , Sesame, kokuzuku, kiban, bekko, etc. are known, and as a herbal medicine having an antidepressant action, hawthorn, cren compi, hishi, kakushitsu, ligan, areca,
Nankashi, Taisan and the like are known.

Examining the literature and the like about these,
It has been found that pharmacological actions such as beautifying action, hair growth-promoting action, anti-allergic action, anti-inflammatory action, and digestion promoting action overlap. Here, the present inventors pay attention, and consider "water" (Tsu liquid).
Works in modern medicine to treat skin disorders such as skin beautification, atopic dermatitis, eczema, dermatomycosis, warts, pigmentation, psoriasis vulgaris, senile xeroderma, senile keratoma and burns It has been found that the action, the hair growth promoting action, the therapeutic action of pimples, the digestive juice secretion promoting action, the sweat promoting action, the diuretic action, the bowel movement promoting action and the like can be used as indices. In addition, substances having one of these actions often have other actions to a greater or lesser degree. Therefore, if screening is performed using one of these actions as an index, other actions can be estimated.

[0018] That is, the composition of the present invention for improving tanning fluid is represented by the action of beautifying skin, the action of treating atopic dermatitis, the action of treating dermatitis represented by eczema, the action of treating dermatomycosis, the action of treating warts, and hepatitis. Therapeutic action for pigmentation disease, psoriasis vulgaris, senile xeroderma, senile keratoma, skin damage treatment due to physical causes, hair growth promoting action, digestive secretion promoting action, sweat promoting action Has an effect of improving at least one selected from the group consisting of a bowel movement promoting effect and a urination promoting (diuretic) effect, and particularly has a beautiful skin effect, atopic dermatitis, eczema, dermatomycosis, warts, It can be expected to remarkably improve the treatment of various skin diseases such as pigmentation, psoriasis vulgaris, senile xeroderma, senile keratoma, burns, etc., and the improvement of hair growth, especially the treatment and prevention of atopic dermatitis Excellent action can be expected.

The composition of the present invention can be administered by any route of administration, but transdermal administration has the highest improvement effect, and transdermal administration is excellent in the effect of improving the essence of the liquor.
Further, it is naturally possible for the composition of the present invention to contain a saccharide and a biocompatible lipid in a single preparation and to use them simultaneously.However, one or both of them are contained in at least two separate preparations, It is also possible to administer them simultaneously or at different times. In this case, it is also possible to administer a combination of different application fields, such as a combination of a cosmetic and a bath preparation, or a bath preparation and a skin external preparation.

[0020]

EXAMPLES Examples of the present invention will be described below, but it goes without saying that the present invention is not limited to only these examples. In addition, all numerical values of the prescription represent parts by weight unless otherwise specified.

[0021]

Examples 1 to 5 Emulsions were prepared according to the formulations shown in Table 1 below. That is, (a), (b), and (c) are each 8
The mixture was dissolved by heating or uniformly dispersed at 0 ° C., (B) was gradually added to (A), and (C) was gradually added to coarsely emulsify and homogenize with a homogenizer to obtain an emulsion.

[0022]

[Table 1]

[0023]

Examples 6 to 10 Emulsions were prepared according to the following formulation. That is, (a), (b), and (c) are 80
The mixture was dissolved by heating or uniformly dispersed at ℃, (B) was gradually added to (A), and (C) was gradually added to coarsely emulsify the mixture, and homogenized with a homogenizer to obtain an emulsion.

[0024]

[Table 2]

[0025]

Examples 11 to 15 An emulsion was prepared according to the following formulation. That is, (a), (b), and (c) are each 8
The mixture was dissolved by heating or uniformly dispersed at 0 ° C., (B) was gradually added to (A), and (C) was gradually added to coarsely emulsify and homogenize with a homogenizer to obtain an emulsion.

[0026]

[Table 3]

[0027]

Examples 16 to 20 Bath agents were prepared according to the following formulation. That is, the ingredients were weighed into a kneader and kneaded well to obtain a bath agent.

[0028]

[Table 4]

[0029]

Example 21 An ointment was prepared according to the following formulation. That is, the ingredients were kneaded well with a kneader to obtain an ointment.

[0030]

[Table 5]

[0031]

Example 22 <Test Example 1: Improving the beautiful skin> A group of 5 panelists aged 21 to 52 years old suffering from rough skin applied the emulsion of Examples 1 to 5 twice a day, morning and evening to the affected area for 2 months. The effect of improving skin roughness was evaluated. The evaluation was performed on a scale of very improved (score 5) to no improvement (score 0). As a control, the saccharide and the biocompatible lipid of Example 1 were replaced with water. The results are shown in Table 6 as average scores. This indicates that the emulsion of the present invention has an effect of improving rough skin, that is, has a beautiful skin effect. Than this,
It can be seen that a combination of a saccharide and a biocompatible lipid has such an effect.

[0032]

[Table 6]

[0033]

Example 23 <Test Example 2: Hair growth promoting action> The back of five C3H mice was shaved, and 200 μl of the emulsion of Examples 1 to 5 was applied.
The subsequent hair growth was observed to evaluate the hair growth promoting action. The control was physiological saline only. Further, Comparative Example 1 was obtained by replacing glucose in Example 1 with water, Comparative Example 2 was obtained by replacing the cerebroside of Example 1 by water, and Comparative Example 3 was obtained by combining glucose and cerebroside of Example 1 with water. Both were replaced with water. Evaluation criteria: ++ (score 4): significantly faster than control, +
(Score 2): earlier than the control, ± (score 1): slightly earlier than the control,-(score 0): not earlier than the control. The results are shown in Table 7 as average scores. This indicates that the combination of the saccharide as the active ingredient of the present invention and the biocompatible lipid is excellent in hair growth promoting action.

[0034]

[Table 7]

[0035]

Example 24 <Test Example 3: Effect on Atopic Dermatitis> Ten groups of panelists aged 20 to 42 years old suffering from atopic dermatitis
The emulsions of Examples 1 to 5 were applied to the affected area twice a day and twice a day for 2 months to evaluate the effect of improving atopic dermatitis.
The evaluation was performed on a scale of very improved (score 5) to no improvement (score 0). As a control, glucose and cerebroside of Example 1 were replaced with water. The results are shown in Table 8 as average scores. This indicates that the emulsion of the present invention has an effect of improving atopic dermatitis. That is, it can be seen that the combination of the saccharide as the active ingredient of the present invention and the biocompatible lipid has such an effect.

[0036]

[Table 8]

[0037]

Example 25 <Test Example 4: Effect on Atopic Dermatitis> Ten groups of panelists aged 20 to 42 years old suffering from atopic dermatitis
The bath preparations of Examples 16 to 20 were used for 2 months to evaluate the effect of improving atopic dermatitis. The evaluation was performed on a scale of very improved (score 5) to no improvement (score 0). As a control, glucose and lecithin of Example 16 were replaced with sodium sulfate. The results are shown in Table 9 as average scores. This indicates that the bath preparation of the present invention has an effect of improving atopic dermatitis. That is, it can be seen that the combination of the saccharide as the active ingredient of the present invention and the biocompatible lipid has such an effect.

[0038]

[Table 9]

[0039]

Example 26 <Test Example 5: Wound healing action> The wound healing action was examined using six Hartley white female guinea pigs per group. That is,
Shaving the back of the guinea pig, creating a 2 cm square area,
This part is stripped five times with a piece of adhesive tape.
Four hours later, 0.05 ml of the sample shown in Table 10 was administered. Seven days after the administration of the sample, the skin reaction was determined according to the Draise criteria shown below, and the average score of the skin reaction was calculated. Table 10 shows the results. This clearly shows the effect of the combination of the saccharide and the biocompatible lipid.

(Draise criterion) ++ (score 2): reaction with edema or eschar, + (score 1): obvious erythema reaction or pigmentation, ± (score 0.
5): Suspicious erythema reaction or pigmentation,-(score 0):
no reaction

[0041]

[Table 10]

[0042]

Example 27 Bath agents having the formulations shown in Table 11 below were prepared. That is, the ingredients listed in Table 11 were mixed in the proportions shown in Table 11, kneaded with a kneader, and divided into 50 g portions.
It was packed in a bag to make a bath agent. This product was prescribed to a 39-year-old woman suffering from constipation and used for one week.
He saw bowel movements a day later and began to experience regular bowel movements once a day from the fifth day.

[0043]

[Table 11]

[0044]

Example 28 A bath agent having the formulation shown in Table 12 below was prepared. That is, the ingredients shown in Table 12 were mixed in the proportions shown in Table 12, kneaded with a kneader, and divided into 50 g portions.
It was packed in a bag to make a bath agent. This product was prescribed to a 42-year-old woman suffering from constipation and used for 2 weeks.
After days, the bowel movement began to improve (increased volume), and after eight days, she began to experience a relatively large amount of bowel movements once every two days, and the abdominal swelling was felt.

[0045]

[Table 12]

[0046]

EFFECTS OF THE INVENTION According to the present invention, cosmetics, external medicines for skin, and baths which are excellent in the effect of improving skin essence, the treatment or prevention of skin diseases such as atopic dermatitis, and the like, and the improvement of the tsukusu effect such as the promotion of hair growth. A composition such as an agent can be provided.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Nobuhiro Ando 27-1, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Prefecture Inside the Yokohama Laboratory, Polar Chemical Industry Co., Ltd. (72) Inventor Yoshie Muramatsu 27, Takashimadai, Kanagawa-ku, Yokohama-shi, Kanagawa Address 1 Inside the Polar Research Kasei Kogyo Co., Ltd. Yokohama Research Laboratory (72) Inventor Mitsuo Kawai 560 Kashio-cho, Totsuka-ku, Yokohama-shi, Kanagawa Pref.

Claims (9)

[Claims] Claims: 1. A tsumumo-improving composition for use in improving tsumumo action, comprising a saccharide and a biocompatible lipid as active ingredients. 2. The saccharide contains one or more selected from the group consisting of glucose, galactose, fructose, mannitol, sorbitol, trehalose, saccharose, arabinose, ribose, deoxyribose, rhamnose and glycerin. 2. The composition according to 1 above. 3. The composition according to claim 1, wherein the biocompatible lipid contains one or more selected from the group consisting of phospholipids, phosphosphingolipids, and glycosphingolipids. 4. The composition according to claim 1, which is an external preparation for skin. 5. The composition according to claim 4, wherein the skin preparation is a cosmetic, a skin preparation or a bath preparation. 6. The method according to claim 1, wherein the essence is a therapeutic or preventive action for skin diseases, a hair growth promoting action, or a beautiful skin effect.
6. The tsutsumo improvement composition according to any one of items 1 to 5. 7. The composition according to claim 6, wherein the skin disease is atopic dermatitis. 8. A composition for treating or preventing a skin disease, comprising a saccharide and a biocompatible lipid as active ingredients. 9. The composition according to claim 8, wherein the skin disease is atopic dermatitis.