JPH0351684B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to industrial disinfectant compositions. [Prior Art] 2-Pyridinethiol-1-oxide or its metal salt is useful as a preservative and antifungal agent for various industrial materials and products such as paints, adhesives, fibers, wall coverings, and flooring materials. However, to obtain practical effects,
It has the disadvantage that it requires addition at a fairly high concentration. For this reason, the range of applications has been significantly limited in this field of severe economic constraints. On the other hand, 2-(4
-Thiazolyl) benzimidazole is selective in its anti-fungal spectrum and lacks suitability as an anti-mildew agent for industrial materials and products exposed to a wide variety of fungal contamination. [Problems to be solved by the invention] Conventionally, attempts have been made to stabilize the antibacterial spectrum and enhance the action by combining various types of bactericides in order to improve their practical effectiveness, but usually only one of them is effective. The reality is that the effects are limited to only the arithmetic average effect. [Means for Solving the Problems] The present inventors have discovered that 2-pyridinethiol-1-oxide or its metal salt and 2-(4-thiazolyl)
The inventors have completed the present invention by discovering that a composition consisting of benzimidazole dramatically increases the antifungal effect compared to when each benzimidazole is used alone. The present invention is an industrial disinfectant composition containing 2-pyridinethiol-1-oxide or a metal salt thereof and 2-(4-thiazolyl)benzimidazole as active ingredients. Examples of metal salts of 2-pyridinethiol-1-oxide include alkali metal salts, alkaline earth metal salts, iron salts, copper salts, lead salts, nickel salts, zinc salts, and tin salts. It is not limited. The disinfectant composition of the present invention can be applied directly or dispersed in a suitable liquid or solid carrier depending on the purpose of use, and if necessary, can be further added with a dispersing agent, suspending agent, adhesive, wetting agent, thickening agent, etc. Wettable powders, powders, granules, pastes, suspensions,
It can be used as a spray agent, etc. It is also possible to mix and use other bactericidal agents, insecticides, deterioration inhibitors, etc. Although the content ratio of the active ingredient in the composition of the present invention can be changed arbitrarily, 2-pyridinethiol-
2-pyridinethiol-1-oxide or its metal salt is 10 to 90% by weight, particularly preferably 30 to 70% by weight, based on the total amount of 1-oxide or its metal salt and 2-(4-thiazolyl)benzimidazole. Since the synergistic effect is especially significant when the above conditions are met, it is desirable to use the compounds within this range. The sterilizing composition of the present invention can be applied to various industrial materials and products that require antiseptic and antifungal properties. Examples of such products include paints, adhesives, fibers, wood and bamboo products, leather, rubber, paper products, medical equipment, electronic parts, wall covering materials, flooring materials, ceiling materials, and the like. [Example] Next, Examples and Test Examples of the present invention will be shown, but the present invention is not limited thereto. In the above description, compound names are abbreviated as follows. Sodium 2-pyridinethiol-1-oxide: NPT Magnesium 2-pyridinethiol-1-oxide: MPT Zinc 2-pyridinethiol-1-oxide:
ZPT 2-(4-thiazolyl)benzimidazole:
TBZ Also, % and parts are weight % and parts by weight, respectively. Example 1 Wettable powder NTP 10%, TBZ 10%, polyoxyethylene octyl phenyl ether sulfate 5%,
75% clay was mixed uniformly and ground to make a wettable powder. Example 2 Suspending agent NTP 15%, TBZ 5%, polyoxyethylene styrylphenyl ether 1.5%, dioctyl sulfosuccinate 1%, white carbon
4% xanthan gum, 0.15% xanthan gum, and 82.35% water were mixed and passed through a wet dispersion mill to form a suspension. Example 3 Powder 5% ZPT, 15% TBZ, and 80% calcium carbonate were mixed and ground in a hammer mill to obtain a powder. Control example 20 for each of NPT, MPT, ZPT, TBZ
% containing single agent was prepared and used as a control example. Test Example 1 Mildew prevention of emulsion paint Vinyl acetate-acrylic emulsion paint (Shinto Paint
Add a specified amount of chemicals to Enbi Co., Ltd. (#60), apply the same weight of paint evenly to the filter paper on No. 5 qualitative filter paper, and after drying, apply the paint as described in JISZ2911 "Mold Resistance Test Method". The antifungal efficacy was evaluated according to the test method. In addition to the types listed in JIS, the sample strains include strains that actually occur on painted walls (Cladosporium sp.
Penicillium sp) was added to the test. Results first
Shown in the table. However, the indication of the degree of mold growth was based on the following criteria. −: No mold growth observed on the test piece. +: The area of mold growth on the test piece does not exceed 1/10 of the total area. ++: The area of mold growth on the test piece is 1/10 to 1/3 of the total area. +++: The area of mold growth on the test piece exceeds 1/3 of the total area. (The results of Test Example 2 were also displayed using the same criteria.)

[Table] As is clear from the results in Table 1, the composition of the present invention had a remarkable antifungal effect compared to the control example when it was used as a single agent. Test Example 2 Mildew prevention of starched cotton cloth 5 parts wheat starch, 2.5 parts PVA, Maconol H
0.5 parts of softener (manufactured by Matsumoto Yushi Co., Ltd.) and 92 parts of water were mixed and heated to form a paste solution. After adding a specified amount of chemicals to the size liquid, impregnate No. 40 broad cotton cloth with the size liquid in an equal weight to the cotton cloth, and after drying, JIS2 2911 "Mold Resistance Test Method"
The antifungal efficacy was evaluated based on the textile product testing method (wet method) described. In addition to the types listed in JIS, a bacterial strain that actually occurred on cotton fabric (Aspergillus sp Alternaria sp) was also tested. The results are shown in Table 2.

[Table] As is clear from the results in Table 2, the composition of the present invention had a remarkable antifungal effect compared to the control example when it was used as a single agent. Test example 3 Preservation and mold prevention of clay Craft clay for teaching materials (manufactured by Yamato Teaching Materials Manufacturing Co., Ltd.) 500
After mixing the specified amount of the drug with g, package it in a plastic bag and store it in a constant temperature and humidity chamber at RH90% and temperature 30℃.
One month later, the state of deterioration caused by microorganisms in the sample was examined. The results are shown in Table 3. The degree of deterioration was determined based on the following criteria. −: No deterioration observed in the sample +: Slight colored spots observed on the sample ++: Specified colored spots and softening observed on the sample +++: Severely colored and liquefied sample

〔Effect of the invention〕

The compositions of the present invention have significantly improved efficacy compared to when used alone, and are suitable as antiseptic and antifungal agents for various industrial materials.

Claims (1)

[Claims] 1. An industrial disinfectant composition comprising 2-pyridinethiol-1-oxide or a metal salt thereof and 2-(4-thiazolyl)benzimidazole as active ingredients.