JPH03261467A - Cancer treating device - Google Patents

Abstract

PURPOSE:To allow the repetitive treatments of the cancer generated in the deep part of a living body by using a light transparent member which allows the transmission of the rays emitted from an acoustochemical luminescence effect material to form a housing container which houses the acoustochemical luminescence effect material and providing a photostimulating semiconductor on the outside surface of the light transparent member. CONSTITUTION:The cancer treating device body 2 is constituted of the container part 6 and the light transparent cap part 8. The acoustochemical luminescence effect material 12 is packed in a space part 4 of the container part 6. A semiconductor electrode 14 as the photostimulating semiconductor having a photocalolytic effect is provided on the outside surface of the light transparent cap part 8. A sheath 24 is plunged to a living dermal tissue 16 and the cancer treating device body 2 is detained in the cancer tissue 20 on the surface of the liver 18 by gripping pincers 28. Ultrasonic signals are oscillated by an ultrasonic oscillator 26 and are amplified by an amplifier 30. These signals are oscillated as ultrasonic waves from an ultrasonic oscillating element 36 of an ultrasonic oscillating probe 34. The cancer treating device body 2 near the cancer tissue 20 is irradiated with these ultrasonic waves via a pouch 38. The acoustochemical luminescence effect material 12 is irradiated with the ultrasonic waves and emits continuous light which kills the cancer tissue 20 in contact with the semiconductor electrode 14.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention provides a cancer treatment device for treating cancer that occurs deep within a living body, such as cancer that occurs in organs such as the liver and pancreas, bone tumors, etc. Regarding.

[Prior Art] Conventionally, as a method for treating malignant tumors such as cancer, there has been known a method of killing cancer cells by utilizing the strong reactivity of a photo-excited semiconductor surface.

As a treatment method applying the above-mentioned effects, for example, Japanese Patent Application No. 1999
As shown in No.-233433, esophageal prosthesis,
T i 02, which is a photo-excited semiconductor, is provided on the surface of a tubular body inserted into a biological conduit such as an ERBD tube in a portion that comes into contact with tumor tissue, and the tumor tissue is killed by endoscopically irradiating it with light. Method and patent application Hei 1-2314
As shown in No. 03, a treatment method in which T i 02, which is a photoexcitable semiconductor, is provided on the outer surface of a balloon to be inserted into a living body, the balloon is brought into contact with the affected area, and light is irradiated from the inside of the balloon toward the semiconductor material. It has been known.

[Problems to be Solved by the Invention] However, the treatment section of the above-mentioned treatment device is a hollow organ such as the esophagus, urethra, bile duct, etc., into which an endoscope or balloon catheter can be inserted, and in which light irradiation can be easily performed. There is a problem in that, for example, it is not possible to treat cancers that occur in organs that are difficult to irradiate with light, such as the liver and pancreas, or in bone tissue.

The present invention has been made in view of the above-mentioned problems, and its purpose is to provide a cancer treatment device that can easily and repeatedly treat cancers that occur deep within the body, where it is difficult to irradiate with light. be.

[Means for Solving the Problems] In order to solve the above problems, the cancer treatment device of the present invention includes a sonochemiluminescence agent that causes sonochemiluminescence by ultrasonic waves, and a storage for storing the sonochemiluminescence agent. At least a portion of the storage container is formed of a light-transmitting member that transmits light emitted from the sonochemiluminescence agent, and a photoexcitable semiconductor is provided on at least a portion of the outer surface of the light-transmitting member.

[Function] In the cancer treatment device according to the present invention, the storage container containing the sonochemiluminescence agent is used to treat cancers that occur deep within the living body, such as organs such as the liver and pancreas, or areas that are difficult to irradiate with light, such as bone tissue. By placing it in contact with the cancerous tissue that has developed in the body and irradiating it with ultrasound from outside the body, the sonochemiluminescence agent inside the storage container can be used as a secondary agent when the cavitation bubbles generated by the ultrasound are collapsed. As an effect, light is generated, and the emitted light passes through the transparent member of the storage container and is irradiated onto the photoexcited semiconductor. As a result, the photoexcited semiconductor causes an oxidation reaction, and the photocatalytic effect kills cancer tissue that has come into contact with the photoexcited semiconductor. Then, treatment is repeatedly performed from outside the body by irradiating ultrasound waves.

[Embodiments] Examples of the present invention will be described below with reference to the drawings.

1 to 4 show a cancer treatment device according to a first embodiment of the present invention. The cancer treatment device main body 2 shown in FIG. It is composed of a light-transmitting lid portion 8 as a light-transmitting member made of quartz glass or the like having optical properties.

A space portion 4 is provided inside this container portion 6 . The container portion 6 and the translucent lid portion 8 are adhesively fixed at a joint portion 10.

Furthermore, the space 4 of the container 6 is filled with an acoustochemiluminescence agent 12 that generates light as a secondary effect when cavitation bubbles generated by externally applied ultrasonic waves are collapsed. . The sonochemiluminescence agent 12 may be, for example, an alkaline aqueous solution of luminol (for example, about 5 g of Na2C in solution II).
o3 and approximately 0.1g of luminol dissolved).

As shown in FIG. 2, on the outer surface of the translucent lid part 8,
A semiconductor electrode 14 made of TiO2 as a photoexcited semiconductor having a photocatalytic effect is provided. This semiconductor electrode 14 is made by mixing TiO2 fine particles with an adhesive resin and spraying the mixture onto the surface of the transparent lid 8 to adhere it. is integrally fixed to. Note that the size of TiO2 fine particles is generally determined by a force (,0,1~10μ), which is between 0.1μ and 1mg+.
A size of about 100g is preferable. Further, the combined size of the container portion 6 and the lid portion 8 is preferably about 3 to 30 mm.

Next, a method for treating cancer generated deep in the soft tissue of a living body, for example, on the surface of the liver, using the cancer treatment device according to the first embodiment of the present invention will be described.

As shown in FIG. 3, the first sheath 22 is punctured into the living skin tissue 16 above or in the vicinity of the cancerous tissue 20 that has developed in the liver 18. Then, an optical viewing tube 32 for observation is inserted into the inner hole of the first sheath 22. Thereafter, the second sheath 2 is applied to the biological skin tissue 16 near the first sheath 22.
Puncture 4.

Then, the cancer treatment device main body 2 is grasped by the grasping forceps 28 inserted through the second sheath 24 and guided to the cancerous tissue 20 on the surface of the liver 18 . This operation is performed while observing with the optical viewing tube 32 inserted into the first sheath 22. Furthermore, when the cancer treatment device body 2 is placed, the semiconductor device 14 provided on the outer surface of the translucent lid portion 8 of the cancer treatment device body 2 is placed in contact with the cancer tissue 20, as shown in FIG. Optical viewing tube 3
The tube will be left in place while being observed in step 2.

In addition, when the cancer treatment device body 2 is left in the body for a long time, the cancer treatment device body 2 may be adhesively fixed to the cancer tissue using a biological adhesive such as fibrin, or the cancer treatment device body 2 may be held with a clip. Alternatively, the cancer treatment device main body 2 may be sutured and fixed to the cancer tissue while being observed through the optical viewing tube 32.

After embedding the cancer treatment device main body 2, the first sheath 22, the second
The sheath 24 and the optical viewing tube 32 and grasping forceps 28 inserted through each are removed from the living skin tissue 16. Thereafter, as shown in FIG. 4, an ultrasonic signal is oscillated by an ultrasonic oscillator 26 placed outside the living body. The oscillated ultrasonic signal is amplified by the amplifier 30 and oscillated as an amplified ultrasonic wave from the ultrasonic oscillation element 36 provided in the ultrasonic oscillation probe 34. As a result, the pouch tightly fixed to the biological skin tissue 16 is emitted. Ultrasonic waves are irradiated via 38 toward the cancer treatment device main body 2 placed near the cancer tissue 20 in the living body.

Since the container portion 3 of the cancer treatment device main body 2 is made of polyvinyl alcohol hydrogel, silicone rubber, etc., which has an acoustic impedance close to that of biological soft tissues, the irradiated ultrasonic waves are transmitted to the space portion 4 of the container portion 6. The sono-chemiluminescent agent 12 thus obtained is reached.

When the sonochemiluminescence agent 12 is irradiated with ultrasonic waves, cavitation bubbles are generated, and when the cavitation bubbles collapse, ions are generated as a secondary effect as the temperature rises, resulting in a spectrum of 350 to 600 nm. Emit continuous light in an area. The emitted light is applied to the semiconductor electrode 14 made of T i 02 provided on the outer surface of the transparent lid 8 through the transparent lid 8 of the cancer treatment device main body 2 . When the semiconductor electrode 14 is irradiated with ultraviolet light of around 400 nm, an oxidation reaction occurs on the semiconductor electrode 14, and the cancer tissue 20 in contact with the semiconductor electrode 14 is killed by the photocatalytic effect.

The cancer treatment device configured in this way can easily and repeatedly treat cancers and bone and flesh tumors that occur in organs that are difficult to irradiate with light, such as the liver and pancreas, by irradiating ultrasound from outside the body. can be done. Therefore, unlike conventional treatment devices using photoexcited semiconductors, the areas that can be treated are not limited to hollow organs into which an endoscope or balloon catheter can be inserted and which can be irradiated with light.

Note that in the first embodiment, the semiconductor electrode is connected to the light-transmitting lid part 8.
The light-transmitting lid portion 8 may be formed by mixing semiconductor fine particles into the material.

Further, in the above embodiment, the case where only one cancer treatment device main body 2 is buried has been described, but a plurality of cancer treatment device main bodies 2 may be buried depending on the size of the cancer tissue 20.

5 and 6 show a cancer treatment device according to a second embodiment of the present invention.

The cancer treatment device main body 40 of the second embodiment is made of a material such as translucent polymethyl methacrylate (PMMA), poly 2-hydroxyethyl methacrylate (PHHMA), polyvinyl alcohol hydrogel, silicone rubber, etc. It is composed of a first translucent container section 42 and a second translucent container section 44, each having an acoustic impedance relatively close to the impedance.

The space 46 formed by the first translucent container part 42 and the second translucent container part 44 is filled with an alkaline solution of luminol that emits light when irradiated with ultrasonic waves, as in the first embodiment. It is filled with a sonochemiluminescent agent 12 . The first translucent container part 42 and the second translucent container part 44 are adhesively fixed at a joint part 48.

Moreover, the first translucent container part 42 and the second translucent container part 4
4, that is, on the entire circumference of the cancer treatment device main body 40, a semiconductor electrode 50 made of T i O 2 as a semiconductor material having a photocatalytic effect as described in the first embodiment is mixed with a resin having adhesive properties. It is applied by spraying. Note that the size of the T i 02 fine particles is about 0.1 μm to 10 μm, as in the first example.
Further, the size of the cancer treatment device main body 40 is preferably about 5 to 3011 mm, same as in the first embodiment.

When using the cancer treatment device according to the second embodiment to treat cancer that has occurred deep in the soft tissues of a living body, the sheath 22, grasping forceps 28, and optical viewing tube 32 are used to treat cancer as shown in FIG. The cancer treatment device main body 40 is connected to the first transparent container part 42 and the second translucent container part 42.
The semiconductor electrode 5 provided on the surface of the translucent container portion 44 of
It is surgically inserted into the body and left in place so that 0 is in contact with the cancerous tissue 20.

Thereafter, ultrasonic waves are irradiated toward the cancer treatment device main body 40 inside the living body via the ultrasound oscillation device 26, amplifier 30, ultrasound oscillation probe 34, pouch 38, etc. arranged outside the living body.

1st. The second translucent container portions 42 and 44 are made of PMMA, which has an acoustic impedance close to that of biological soft tissue.

Since it is made of PHEMA, PVA hydrogel, silicone rubber, etc., the irradiated ultrasonic waves are It reaches the sonochemiluminescence agent 12 filled in the space 46 of the second translucent container part 42,44.

Then, the sonochemiluminescence agent 12 made of an alkaline solution of luminol emits light and passes through the first and second light-transmitting container portions 42 and 44, and is then exposed to the T provided on the surface.
Light is irradiated onto the semiconductor electrode 50 made of i02. An oxidation reaction occurs on the semiconductor electrode 50 due to the irradiated light, and the cancer tissue 20 that has come into contact with the semiconductor electrode 50 can be killed by the photocatalytic effect.

In the cancer treatment device configured as described above, both the first translucent container section 42 and the second translucent container section 44 filled with the sonochemiluminescence agent are made of PMMA, PHEMA,
Since it is made of a translucent material such as PVA hydrogel or silicone rubber, it is possible to easily and repeatedly treat a wider range of cancer tissues from outside the body than in the first embodiment.

7 to 8 show a cancer treatment device according to a third embodiment of the present invention.

The third embodiment relates to a treatment device used to prevent recurrence after bone tumor removal. As shown in FIG. 7, the hollow after bone tumor removal is filled with a translucent external bone filling material 52, and this translucent external bone filling material 52 is made of β-TCP, hydroxyapatite (RAP), alumina, etc. It is made of a biocompatible ceramic material, and these ceramic materials are formed to be dense and translucent by HIP treatment. A hole 54 is provided in the transparent external bone filling material 52, and a transparent bag-like member 56 made of a material such as silicone that is transparent and has an acoustic impedance close to that of biological soft tissue is fixed by adhesive or the like. There is. The inside of the transparent bag-like member 56 is filled with a sonochemiluminescent substance 12 made of an alkaline solution of luminol.

Furthermore, as shown in FIG. 8, a semiconductor electrode layer 6 in which Pt60 is supported on Ti0258 as a semiconductor material having a photocatalytic effect is provided at an appropriate portion of the outer surface of the light-transmitting external bone filling material 52.
2 is mixed with an adhesive resin and attached by spraying. In addition, the size of the fine particles in which pt is supported on T i 02 is about 0.1 to 10 μm.

Next, a method for preventing recurrence after bone tumor removal using the light-transmitting external bone filling material 52 according to the third embodiment will be described.

First, the light-transmitting external bone filling material 52 is applied to the bone tissue 64 after bone tumor removal.
Fill the hollow. and alumina, β-TCP%H
A bone via 66 made of a biocompatible ceramic material such as AP is screwed into the bone tissue 64 and fixed. If tumor tissue recurs at the site where the bone tumor was removed, the first
．． Ultrasonic oscillation device 26, amplifier 30, ultrasonic oscillation probe 34, and pouch 3 placed outside the living body as in the second embodiment
Ultrasonic waves are irradiated toward the light-transmitting external bone filling material 52 in the living body through a tube such as 8 or the like. The irradiated ultrasonic waves reach the transparent bag-like member 56 provided in the hole 54 of the light-transmitting external bone filling material 52 via the soft tissue of the living body, but the transparent bag-like member 56 is made of soft tissue such as silicone and acoustically Since it is made of materials with similar impedance, it further reaches the sonochemiluminescence agent 12 inside the transparent bag-like member 56. And the first. As in the second embodiment, the acoustochemiluminescence agent 12 emits light and passes through the transparent bag-like member 56 and the translucent external bone filling material 52 to the 'rio' provided on the surface of the translucent external bone filling material 52. , , Semiconductor electrode layer 62 made of PT
light is irradiated on.

The irradiated light causes an oxidation reaction on the semiconductor electrode layer 62 made of TiO2 and Pt, and the recurrent tumor tissue in contact with the semiconductor electrode layer 62 can be killed by the photocatalytic effect.

In the cancer treatment device configured in this way, the transparent bone filling material 5
2. T as a semiconductor material with photocatalytic effect on the surface
Since the semiconductor electrode layer 62 in which iO2 supports pt is provided, the first. The cancer tissue killing effect is greater than that in the case of using T i 02 alone in the second example.

[Effects of the Invention] As explained above, in the cancer treatment device according to the present invention, unlike conventional treatment devices using photoexcited semiconductors, the cancer treatment device can be used to treat areas such as the esophagus, urethra, bile duct, etc. through which an endoscope or balloon catheter is inserted. Moreover, it is not limited to hollow organs that can be easily irradiated with light, and can be easily applied ex vivo to cancers that occur deep within the body, such as organs such as the liver and pancreas, or bone tissue, where it is difficult to irradiate with light. Treatment can be repeated.

[Brief explanation of drawings]

FIG. 1 is a longitudinal cross-sectional view of a cancer treatment device according to a first embodiment of the present invention, FIG. 2 is a cross-sectional view showing the outer surface of a transparent member of the cancer treatment device according to the first embodiment, and FIG. FIG. 4 is a side view showing the method of embedding the cancer treatment device, FIG. 4 is a diagram showing the operating state of the cancer treatment device, FIG. 5 is a longitudinal sectional view of the cancer treatment device according to the second embodiment of the present invention, and FIG. 7 shows the operating state of the cancer treatment device according to the third embodiment of the present invention, and FIG. 8 shows the operating state of the cancer treatment device according to the third embodiment of the present invention.
FIG. 3 is a cross-sectional view showing the surface of a light-transmitting member according to an example. 2... Cancer treatment device main body, 6... Container part (storage container)
, 8... Translucent lid part (light-transmitting member), 12... Sonochemiluminescence agent, 14... Semiconductor electrode (photoexcited semiconductor)

Claims (1)

[Claims] It comprises a sonochemiluminescence agent that causes sonochemiluminescence by ultrasonic waves, and a storage container that stores the sonochemiluminescence agent, and at least a portion of the storage container transmits light emitted from the sonochemiluminescence agent. It is formed of a transparent member that allows
A cancer treatment device characterized in that a photoexcitable semiconductor is provided on at least a portion of the outer surface of the light-transmitting member.