JPH0299862A - Tablet measuring apparatus - Google Patents

Abstract

PURPOSE:To enable an automation of various testings for tablets with different shapes, a shorter test time and a higher accuracy of the results of a test by arranging blades radially on a plurality of conveying rotors being projected to form zones for receiving tablets. CONSTITUTION:Tablets A are supplied to blades 4 of a conveying rotor 3 via a conveying chute 1 from a tablet supply section 2 and placed sequentially at a non-destructive mechanism 13 for measuring the weight, diameter and thickness with an intermittent movement of the rotor 3. Then, the results of a test undergoes a data processing automatically to be recorded and displayed. Then, the hardness of the tablets A placed on the mechanism 13 is measured to be recorded and displayed. In this case, when transferred with the blades 4, the tablets A are placed on a regulation surface 5 always being moved in the direction of the outer circumference with a tablet guide piece 7 provided on a track 6. This eliminates a centering deviation and scattering and errors in the results of measurement with an accurate and automatic positioning, thereby enabling the obtaining of correct results of measurement quickly.

Description

Detailed Description of the Invention [Field of Industrial Application] The present invention is directed to the hardness required for analysis in solid tablets, granules, granules, granules, etc. for pharmaceutical products, foodstuffs, chemicals, etc.;
This invention relates to a measuring device for measuring and testing physical properties such as weight and shape.

[Conventional technology]

In general, quality control through chemical analysis has the most important meaning when manufacturing pharmaceuticals, etc. Regulations such as weight deviation and disintegration are determined by the Japanese Pharmacopoeia, and in particular, to ensure the accuracy of dosage. Testing the hardness and friability of tablets,
It is known to perform measurements such as thickness, diameter and weight.

Conventionally, non-destructive tests that do not change the tablet's dimensions, such as its diameter and thickness, and destructive tests that change the tablet, such as crushing, dissolution, abrasion, etc., have been conducted manually using various testing machines, either separately or continuously. ing.

(Problem to be solved by the invention) However, since these testing operations are performed manually, the testing speed is not satisfactory even if they are performed continuously.Moreover, recently, tests have been performed not only on flat circular shapes but also on elliptical or irregular shapes. There are tablets of various shapes with spherical surfaces, which can cause problems in transportation, and it is often difficult to maintain the orientation and hold position at each test position, resulting in test results that tend to vary and lack accuracy. In particular, in response to the demand for highly accurate testing even when various tablets are supplied indiscriminately, it is cumbersome to transport tablets of various shapes by changing the 7-tasotment each time. There were handling problems as tablets could no longer be supplied.

The present invention provides an easy-to-configure tablet measuring device that can shorten working time and make test results more accurate when automatically performing various tests on tablets with various irregular shapes in a continuous manner in these conventional solid state property tests. The aim is to provide it in an inexpensive format.

[Failure to solve the problem]

The present invention includes a tablet supply unit having a transfer chute, and a rotatable transfer rotor connected to the transfer chute, in order to perform physical property tests of solid tablets such as pharmaceuticals, including destructive tests and non-destructive tests. In the tablet measuring device, a plurality of blades forming compartments for receiving the tablets are provided radially protruding from the conveying rotor, and a track having a regulating surface is provided to allow the blades to pass and come into contact with the tablets transferred by the blades; The tablet measuring device is characterized in that a tablet guide piece, through which the blade can pass, is provided on the surface of the track and is oriented obliquely in the outer circumferential direction.

[For production]

In this tablet measuring device, tablets are supplied from a supply section through a transfer chute to a tablet receiving section of a conveyor rotor, and by intermittent movement of the conveyor rotor, the tablets are sequentially placed in a non-destructive testing mechanism that measures weight, diameter, and thickness. In addition to automatically processing and recording and displaying test results, the system also measures the hardness of tablets placed in a destructive testing mechanism, processes the results, and continuously records and displays them. When the tablets are transported by the blades of the transport rotor, the tablets are constantly moved in the outer circumferential direction by the tablet guide piece provided on the track and can be placed on the printing surface, so positioning is automatically performed reliably and there is no centering error, making it easy to measure. Accurate measurement and analysis results can be obtained quickly without variations or errors in the results.In the weighing section, the tablet is returned from the control surface using a flexible piece and kept in an isolated position, reducing the contact friction of the tablet. The resistance prevents measurement errors, and the moving blade automatically cleans the track surface and measuring section with a flexible scraper piece to properly remove broken tablet fragments and powder to improve accuracy. This can enable significantly improved measurements.

〔Example〕

An embodiment of the present invention will be described with reference to the drawings. It includes a tablet supply section 2 that can store tablets such as pharmaceuticals, a transfer shoe 1 that delivers the tablets from the tablet supply section 2, and a blade that aligns and carries out the tablets. A transport rotor 3 is rotatably provided in a track 6, and a transport rotor 3 is rotatably provided in a track 6, and a tablet receiving part for receiving tablets taken out from the transport chute 1 is partitioned by a blade 4. It is equipped with a destructive testing mechanism 13 consisting of a hardness measuring section and a disintegration measuring section capable of measuring the weight and abrasion of the tablet.
A test section equipped with a non-destructive testing mechanism consisting of a weight measurement section 14 capable of measuring diameter and thickness, and a thickness and diameter measurement section 15, and a display section B that processes and records and displays the measured values of each test result. , a recording section C that processes this data and prints and derives average values and standard deviations, and a data processing section that includes a tablet supply operation setting keyboard.

Tablets A are supplied to the transport rotor 3 which rotates intermittently through the transport chute 1 in the tablet supply section 2, and are moved and placed in each of the test mechanisms to perform a measurement test. A plurality of blades 4 for receiving tablets and conveying them in the outer circumferential direction are protruded radially, and a track 6 is provided for moving and placing the tablet receiving portion partitioned between the blades 4 and 4 in each of the test mechanisms. It is formed.

In addition, the non-destructive test mentioned above can be performed by installing a measuring unit that measures color difference, surface area, and other necessary items in addition to diameter and thickness, and in addition to hardness and disintegration degree, the destructive test can also measure elution degree,
Various tests such as friability and chemical analysis can be freely selected with the attached measuring section, and these continuously checked measured values are A.
The data is processed by the data processing section, which includes a /D converter and a computer unit, and displayed on the display section B, which has a digital display window, and is reproduced and derived by the recording section C, which includes a setting section that allows you to arbitrarily set the measurement range manually, a printer, and a monitor. Please contact us to let us know.

In other words, the weight, thickness, tablet diameter, and hardness required for the tablet are automatically and accurately measured continuously, and the measurement results are displayed digitally as well as the average value, relative standard deviation, absolute standard deviation, minimum, and maximum. Values can be recorded using a standard printer or information can be transmitted using a computer unit, and measurement results for up to 100 items can be statistically analyzed using a statistical data program built into the recording section C.

The conveyance rotor 3 is a rotary disk that rotates intermittently, with a plurality of blades 4 protruding from the outer periphery, and the blades 4 are intermittently moved forward and backward so that the tablets are at the center position during measurement. A tablet receiving section is defined by a gap that widens toward the outer circumference between each blade 4. A regulating surface 5 serves as a circumferential wall surface against which the tablet A passes through and is transferred by the blade 4. Each test in which a certain track 6 was provided, and tablet guide pieces 7 through which the blade 4 could pass were provided on the surface of the track 6 in an inclined orientation toward the outer circumferential direction, and the tablets A were sequentially arranged while being pressed against the circumferential wall side. It is designed so that it can be placed in the measuring section for use. In this case, the tablet guide piece 7 is a thin strip made of aluminum whose entire or tip portion is curved, and the track 6
Although one or more rails are detachably installed on the surface of the track 6 via an adhesive, it may also be a rail formed integrally with the track 6, and is provided at a predetermined angle to intersect the blade 4. .

Further, the tablet supply section 2 includes a tablet cassette 2 in the feeder.
Magazine 2 that can hold the required number of □ cents and supply one piece at a time.
The tablet A is inserted into the tablet receiving section between the blades 4.4 formed on the conveying loaf 3 and sequentially conveyed.

In addition, a blade 4 forming a compartment for receiving the tablet A is provided.
A concave groove track 6 having a regulating surface 5 that abuts the tablet A to be transferred is provided in a ring shape, and a flexible piece 8 is retractably provided on the regulating surface 5 at the position of the weight measuring part of the tablet A. For example, a spring plate with a free end at one end is protruded, or a pivot piece biased by a spring or sponge, or a barrier member coated with a slippery sheet or a slippery layer is used to transport the material. Guide tablet A to a position slightly inward,
A flexible scraper is placed away from the side of the track 6 and placed on the scale table to accurately measure the weight, and is in contact with the surface of the ring-shaped track 6 through which the blade 4 is inserted. The piece 9 is provided so as to protrude from the lower surface, upper surface, or side surface of the blade 4 to remove powder, debris, etc. adhering to or existing on the inner surface of the track 6 and the surface of the measuring section.

The flexible scraper piece 9 is made of a synthetic resin sheet, such as Tetron (trade name) Teflon.

It is held in a rod-shaped holder 10 using a rubbing member such as nylon, vinylon, other synthetic rubber, or felt.
The blade 4, which is provided with a fitting hole 11 of the holder 10 and a slint groove (12) into which the scraper piece 9 is inserted, is detachably fitted into the blade 4.

In the track 6 through which the blade 4 passes, a protrusion 16 is formed inwardly on both sides of the track 6 at the position where the destructive testing mechanism 13 is installed, and a narrow overflow is formed to prevent the blade 4 from passing. In this case, it is preferable to construct the scraper piece 9 so that it passes through the scraper piece 9 in a bendable manner.

In the figure, 17 is a stopper piece, 18 is an insertion groove, and 20 is a printer.

In the device of this example, the measurement range is 0.001 to 3 grammage
0.000g±0.001g, thickness 0.05-10.
00 m±0.02 dragon, hardness 1~30ON, ±IN,
The diameter is 1.00 to 25.00 ± 0.02, the resolution can be increased to basis weight o, ootg, thickness 0゜01m, hardness IN, and diameter 0.01m, and the measurement speed is 6 to 10.
It is possible to work at speeds of 1 tablet/minute.

〔Effect of the invention〕

The present invention provides a plurality of blades protruding radially from the conveying rotor that form compartments for receiving tablets, a track having a regulating surface that passes through the blades and comes into contact with the tablets transferred by the blades, and a track that has a regulating surface that abuts the tablets transferred by the blades. Since the tablet guide piece that allows the blade to pass through is provided at an angle in the outer circumferential direction on the surface of the tablet, even if tablets of various shapes are fed to the truck, the blades can accurately transfer them in the outer circumferential direction to the regulating surface. It can be moved and fixed in each testing mechanism, and the basis weight, thickness, and tablet diameter of the tablet can be detected at each measuring section to perform non-destructive testing. In addition to being able to accurately measure and record and display data continuously, this measurement can be performed automatically to shorten work time, and the test results are reliable and have no measurement errors, making it possible to quickly obtain useful data. It can be processed extremely economically.

[Brief explanation of the drawing]

The drawings show an embodiment of the present invention, and FIG. 1 is a plan view, FIG. 2 is a vertical sectional view taken along line 1-1 in FIG. 1, and FIG. 3 is a vertical sectional view taken along line nn in FIG. 4 is a cutaway front view taken along the line m--m in FIG. 3, and FIG. 5 is a perspective view of the device in use. A...Tablet, B...Display section, C...Recording section, D.
...Data processing section, 1...Transfer chute, 2...Tablet supply section, 3...Transport rotor, 4...Blade, 5
... Regulatory surface, 6... Track, 7... Tablet guide piece, 8... Flexible piece, 9... Scraper piece, 10...
... Holder, 11 ... Fitting hole, 12 ... Slit groove, 13 ... Destructive test mechanism, 14 ... Weight measurement part,
15...Diameter side thickness and diameter measurement part.

Claims (8)

[Claims] (1) A tablet supply section (2) having a transfer chute (1) and a device connected to the transfer chute (1) in order to perform physical property tests of solid tablets (A) such as pharmaceuticals, including destructive and non-destructive tests. In a tablet measuring device equipped with a rotatable transport rotor (3), the transport rotor (3) has a plurality of blades (4) radially arranged to form a section for receiving the tablet (A).
The blade (4) is passed through the blade (4).
4) is provided with a track (6) having a regulating surface (5) that abuts the tablets (A) to be transferred, and the track (6)
A tablet measuring device characterized in that a tablet guide piece (7) through which the blade (4) can pass is provided on the surface of the tablet guide piece (7) and is oriented obliquely in the outer circumferential direction. (2) The tablet guide piece (7) according to claim 1, wherein the tablet guide piece (7) is a thin curved aluminum wall and is detachably installed on the surface of the track (6) via an adhesive. Tablet measuring device. (3) Destructive testing mechanism consisting of a hardness measuring section that can measure the hardness of tablets (A) by subjecting them to splitting or abrasion changes in a track (6) that is partitioned facing the transfer chute (1) of the tablet supply section (2). 3. The tablet measuring device according to claim 1, further comprising: and a nondestructive testing mechanism capable of measuring the weight, thickness, diameter, etc. of the tablet (A), arranged in sequence. (4) A conveyance rotor (3) having a plurality of radially protruding blades (4) forming compartments for receiving the tablets (A) is rotatably provided, and the blades (4) are fitted into the conveyor rotor (3) and the blades A ring-shaped concave groove track (6) having a regulating surface (5) that contacts the tablet (A) to be transferred at step (4) is provided in a ring shape, and the regulating surface (5) is provided at the position of the weight measuring part of the tablet (A). ) is equipped with a flexible piece (8) that can be freely protruded and retracted. (5) A transport rotor (3) is rotatably provided with a plurality of blades (4) protruding radially forming compartments for receiving the tablets (A), and a ring-shaped conveyor rotor (3) is provided to allow the blades (4) to fit and pass through. A tablet measuring device characterized in that a flexible scraper piece (9) that comes into contact with the surface of the track (6) is provided in a protruding manner on the lower surface of the blade (4). (6) The flexible scraper piece (9) is a synthetic resin sheet and is held in a holder (10), and the scraper piece (9) is connected to the fitting hole (11) of the holder (10).
The tablet measuring device according to claim 5, wherein the tablet measuring device is detachably inserted into the blade (4) provided with a slit groove (12) into which the tablet is inserted. (7) A track (6) for passing the blade (4)
Claim 5 or 6, wherein both sides of the track (6) on which the destructive testing mechanism is installed are protruded inward to form a narrow part so that the scraper piece (9) can bend and pass through. tablet measuring device. (8) The tablet supply section (2) has a feeder, and the tablet receiving section is partitioned into multiple sections by the blades (4) of the conveyance rotor (3) on the track (6). 6. The tablet measuring device according to claim 1, wherein the tablet (A) is fed sequentially.