JPH02280772A - Percutaneous medicine-gradually exerting-coated material - Google Patents

Abstract

PURPOSE:To apply medicine in the 'put-on-clothes' feeling and prevent skin aspiration or sweating from being obstructed, by coating the surface of a flexible sheet-basic cloth with the power or liquid material of the percutaneous medicine through a proper binder and forming a percutaneous medicine-gradually exerting layer. CONSTITUTION:A flexible basic cloth 1 is formed from woven fabric, braided cloth or nonwoven fabric having a percutaneous medicine-gradually exerting layer 2 on one surface. The percutaneous medicine-gradually exerting layer 2 is constituted of a coating film 5 in which the minute particles of the percutaneous medicine 3 and the percutaneous absorption- accelerating medicine 4 are coated by the high polymeric compounds which decompose through the lapse of time and consist of oxyacid and lactone compound, respectively, and these compounds are kneaded in a binder 6 which consists of the dissolved polyester resin, etc., and coated to a proper thickness. When a supporter is constituted of the percutaneous medicine-gradually exerting-coated material, the percutaneous medicine in the binder which constitutes the percutaneous medicine-gradually exerting layer of the percutaneous medicine- gradually exerting-coated material oozes through transition, and the medicine is applied through skin. In this case, the percutaneous medicine having a coating film is released by the removal of the coating film.

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a transdermal drug sustained release dressing material related to transdermal drug administration technology.

[Prior Art] As a sustained drug release agent, which is a material that gradually releases a drug while adjusting the concentration, it has been used in some cases as a poultice and the like.

[Problems to be Solved by the Invention] However, these poultices are generally used by adhering and holding a paste-like transpiration additive applied to a base fabric and a drug mixed with the shoulder surface of the skin. The problem was that the release rate was relatively short and it was difficult to control. Furthermore, since these poultices adhere closely to the skin surface, they cannot be used continuously for a long period of time or used simultaneously over a wide range of problems, such as preventing the skin from breathing and sweating.

The present invention was made in view of the above problems, and provides a transdermal drug that can be administered with the feeling of "wearing it" and can be controlled over a long period of time without interfering with skin respiration or sweating. The purpose is to provide radiation clothing materials.

[Means for Solving the Problems] The transdermal drug sustained release dressing material according to the present invention is a material in which a transdermal drug is present in a binder coated on a base fabric so as to have a sustained release effect. The gist of this method is to cause a powder or liquid transdermal drug to ooze out from a binder over time. In addition, the transdermal drug sustained release dressing material is made of a polymer compound liquid S that has the property of decomposing or sublimating the fine powder of the transdermal drug over time.
(hereinafter referred to as a "coating film"), the coated transdermal drug fine powder is applied to the surface of a flexible sheet-like base fabric via an appropriate binder, and a transdermal drug sustained release layer is formed. Its purpose is to form a

Further, when the binder has adhesive properties, a porous sheet may be attached to the surface of the transdermal drug sustained release layer.

Instead of the above-mentioned transdermal drug, a structure in which fine particles consisting of a mixture of a transdermal drug and a transdermal absorption-promoting drug are coated with a polymeric compound film having a property of decomposing or sublimating over time is preferable.

The gist of the above-mentioned transdermal sustained drug release clothing material is to be used by sewing it into the structure of underwear, supporters, or nightwear.

[Function] For example, when a supporter is made of a transdermal sustained drug release dressing, the transdermal drug in the binder forming the sustained transdermal drug release layer formed on the sustained transdermal drug release dressing material oozes out due to migration. , administered through the skin. At this time, transdermal drugs provided with a coating are released when the coating is dissolved. Since the resolution time of the polymer compound coating can be changed by changing the type of compound, for example, an oxyacid and a lactone compound, the release rate of the transdermal drug can be controlled over a long period of time.

In addition, the supporter can be used as if it were being "worn", and although it is in contact with the skin surface, it does not adhere to the skin or seal that surface, so it does not prevent the skin from breathing or sweating. This allows for long-term continuous use, wide range of simultaneous use, and transdermal drug administration.

[Example] Hereinafter, a transdermal sustained drug release dressing according to the present invention will be described with reference to the drawings.

FIG. 1 is an explanatory diagram of a microscopically enlarged cross-section showing the first embodiment, in which reference numeral 1 indicates a transdermal sustained drug release layer 2 formed on one side.
It is a flexible base fabric made of a woven fabric, a non-woven fabric, or the like. The above-mentioned transdermal drug sustained release layer 2 has fine particles of a transdermal drug 3 and a transdermal absorption-promoting drug 4, which will be described later, coated with a time-degradable polymer compound consisting of an oxyacid and a lactone compound, respectively, and forms a coating film 5. These are kneaded into a dissolved binder 6 such as polyester resin, and coated to an appropriate layer thickness.

Further, FIG. 2 shows another embodiment using a binder having adhesive properties, and the binder 6 in the first embodiment has adhesive properties.

In this case, the transdermal drug sustained release layer 2 has a structure in which a porous sheet 7 made of a flexible film, woven cloth, knitted cloth, nonwoven cloth, etc. is adhered to the surface of the transdermal drug sustained release layer 2.

It goes without saying that in other embodiments, the structure of the coating film 5 in each of the above embodiments can be abolished, and by selecting the binder 6, the transdermal drug 3
can be used in the form of liquid as well as fine particles.

After pulverizing the dermatological drug to a particle size of 10 μm or less, the fine particles are coated with a time-degradable polymer compound consisting of an oxyacid and a lactone compound. At this time, the types of oxyacid and lactone compound are changed, and the combination of the compounds is changed so that the decomposition resolution time is different for each.

The same applies to the coating treatment of drugs that promote transdermal absorption.

Coronary vasodilators (3) Hormonal agents (4) Antipyretic, analgesic, antiinflammatory, and antipruritic agents Steroid preparations, non-steroid preparations, antihistamine preparations (5) Antiemetics (8) Hormonal drugs Can be used as transdermal drugs Examples of drugs A1 Locally applicable drugs (1) Anti-inflammatory and analgesic salicylic acid preparations, steroid preparations, non-steroidal preparations (2) Antitumor agent B, systemically applicable drugs (1) Anti-motion sickness agents (2) Cardiovascular agents (1) Aliphatic hydrocarbon ester pyrrolidone derivative of azacycloalkane 2-one 1-alkyl-2-pyrrolidone-5-carboxylic acid (2) Other Darmsiac, 5epas, 1 UL, 9JU (1) Supporter, stripe, mask, etc. medical aid supplies.

(2) Clothing such as undershirts, pants, briefs, socks, etc.

(3) Bedding such as sheets, duvet covers, pillowcases, etc.

[Effects of the Invention] As described above, according to the sustained transdermal drug release clothing material of the present invention, the transdermal drug is released from the sustained transdermal drug release layer laminated on the base fabric to 31I! Since the release rate of the transdermal drug can be freely controlled, it is possible to administer the drug with high safety. In addition, it can be used as if it were worn, and since the skin surface is not sealed, it does not impede skin breathing or sweating, making it possible to use it continuously for a long period of time and to use it simultaneously over a wide range of areas. It has the advantage of having advantages in administration, and the influence it will have on the pharmaceutical industry after implementation of the present invention will be extremely large.

FIG. 2 is an explanatory diagram of an enlarged microscopic cross section showing an example of a sustained drug release dressing material.

1... Base fabric, 2... Transdermal drug sustained release layer, 3... Transdermal drug.

4... Transdermal absorption promoting drug, 5... Coating film, 6... Binder, 7... Porous sheet.

[Brief explanation of drawings]

Claims (6)

[Claims] (1) A transdermal drug sustained release dressing material formed by applying transdermal drug powder or liquid to the surface of a flexible sheet-like base fabric via an appropriate binder to form a transdermal drug sustained release layer. . (2) The transdermal drug sustained release dressing material according to claim 1, wherein the transdermal drug is composed of powder or granules, and the powder or granules are coated with a polymeric compound film having a property of decomposing or sublimating over time. (3) Claim 1 or 2, wherein the binder is adhesive and a porous sheet is attached to the surface of the transdermal sustained drug release layer.
The transdermal sustained drug release dressing material described above. (4) The transdermal sustained drug release dressing material according to any one of claims 1 to 3, wherein the polymeric compound coating having the property of decomposing or sublimating over time is a combination of different types of compounds consisting of an oxyacid and a lactone compound. . (5) The sustained transdermal drug release dressing material according to any one of claims 1 to 4, which is made by kneading a mixture of a transdermal drug and a transdermal absorption-promoting drug with a binder instead of the transdermal drug. (6) The sustained transdermal drug release dressing material according to claim 1, wherein the transdermal drug is a liquid, and the transdermal drug is directly impregnated into a base fabric and dried.