JPH02154763A - Method for removing hydrogen peroxide - Google Patents
Method for removing hydrogen peroxideInfo
- Publication number
- JPH02154763A JPH02154763A JP63308538A JP30853888A JPH02154763A JP H02154763 A JPH02154763 A JP H02154763A JP 63308538 A JP63308538 A JP 63308538A JP 30853888 A JP30853888 A JP 30853888A JP H02154763 A JPH02154763 A JP H02154763A
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen peroxide
- soft contact
- lens
- contact lens
- lenses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 134
- 238000000034 method Methods 0.000 title claims description 25
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 230000001678 irradiating effect Effects 0.000 claims abstract description 5
- 238000002604 ultrasonography Methods 0.000 claims description 13
- 239000007864 aqueous solution Substances 0.000 claims description 9
- 230000001954 sterilising effect Effects 0.000 abstract description 12
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 7
- DAEPDZWVDSPTHF-UHFFFAOYSA-M sodium pyruvate Chemical compound [Na+].CC(=O)C([O-])=O DAEPDZWVDSPTHF-UHFFFAOYSA-M 0.000 abstract description 4
- 102000003992 Peroxidases Human genes 0.000 abstract description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 abstract description 2
- 229940054269 sodium pyruvate Drugs 0.000 abstract description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 abstract description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 abstract description 2
- 239000011344 liquid material Substances 0.000 abstract 1
- 239000003863 metallic catalyst Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 238000007654 immersion Methods 0.000 description 8
- 239000011521 glass Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- DCKVFVYPWDKYDN-UHFFFAOYSA-L oxygen(2-);titanium(4+);sulfate Chemical compound [O-2].[Ti+4].[O-]S([O-])(=O)=O DCKVFVYPWDKYDN-UHFFFAOYSA-L 0.000 description 2
- 229910000348 titanium sulfate Inorganic materials 0.000 description 2
- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- OKBPCTLSPGDQBO-UHFFFAOYSA-L disodium;dichloride Chemical compound [Na+].[Na+].[Cl-].[Cl-] OKBPCTLSPGDQBO-UHFFFAOYSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000012414 sterilization procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
Description
本発明は、過酸化水素水溶液を用いた殺菌処理によりソ
フトコンタクトレンズの殺菌をした後ソフトコンタクト
レンズを除去剤に浸漬してソフトコンタクトレンズから
過酸化水素を辞去する方法において、除去剤に浸漬した
ソフトコンタクトレンズに超音波を照射することにより
過酸化水素を効率的に除去する方法に関するものである
。The present invention provides a method of sterilizing soft contact lenses through sterilization treatment using an aqueous hydrogen peroxide solution, and then immersing the soft contact lenses in a remover to remove hydrogen peroxide from the soft contact lenses. The present invention relates to a method for efficiently removing hydrogen peroxide by irradiating soft contact lenses with ultrasonic waves.
ソフトコンタクトレンズは人眼の屈折力の°矯正に広く
使用されているが、使用によって雑菌等によりその表面
が汚染され易く、汚染されると眼の感染症を引き起こす
可能性が大きいところから、一定時間の使用後はソフト
コンタクトレンズを眼より取り外して洗浄し、かつ所定
の方法にて表面を殺菌処理に附すことが日常的に必須な
管理操作となっている。この殺菌の方法には従来、加熱
による方法、殺菌作用のある薬物を含んだ液に一定時間
浸漬する方法及び所定濃度の過酸化水素を含む水溶液に
一定時間浸漬させる方法が知られている。Soft contact lenses are widely used to correct the refractive power of the human eye. After a period of use, soft contact lenses are removed from the eye, washed, and the surface is sterilized using a prescribed method, which is an essential management operation on a daily basis. Conventionally known methods of sterilization include heating, immersion in a solution containing a sterilizing drug for a certain period of time, and immersion in an aqueous solution containing hydrogen peroxide at a predetermined concentration for a certain period of time.
上記の方法のうち、ソフトコンタクトレンズを所定の濃
度の過酸化水素を含んだ溶液に一定時間浸漬することに
よって殺菌する方法においては、その具体的操作は、過
酸化水素を通常約３％以下の濃度に含有する水溶液にソ
フトコンタクトレンズを通常１０分ないしそれ以上の時
間浸漬して殺菌手順自体を終了し、その後、該ソフトコ
ンタクトレンズを過酸化水素の水溶液より取り出して過
酸化水素除去剤（以下「除去剤」という）に浸漬すると
いう処理によって、レンズに付着又は浸透している過酸
化水素を除去することによって操作全体を完了するとい
うものであった。かかるソフトコンタクトレンズ中の過
酸化水素を除去するに用いられる除去剤としては、例え
ばチオ硫酸ナトリウム、ピルビン酸ナトリウム、パーオ
キシダーゼ等を主成分とする液剤及び金属触媒が用いら
れているが、除去剤がいずれのものであっても本発明の
方法を適用して過酸化水素を除去することができる。過
酸化水素水溶液によりソフトコンタクトレンズを処理す
ることは殺菌効果の点では極めて有効な方法ではあるが
、その反面、当方法においては必須である、殺菌後の過
酸化水素の除去に関し、ソフトコンタクトレンズに付着
又は浸透した過酸化水素のうち一部は除去剤に浸漬する
操作のみによっては速やかには除去されにくいという欠
点を持っていた。すなわち、殺菌終了後のソフトコンタ
クトレンズを除去剤に浸漬するのみでは、ソフトコンタ
クトレンズに付着又は浸透した過酸化水素の一部は徐々
にしか除去されないため、通常実施される短時間の除去
操作ではソフトコンタクトレンズの内部には浸透した過
酸化水素の一部が残留し、これをほぼ完全に（例えばｌ
レンズ当り１μｇ以下）に除去するだめには、ソフトコ
ンタクトレンズを除去剤に長時間浸漬しておく必要があ
った。ソフトコンタクトレンズの殺菌は毎日繰り返され
るべき、衛生管理上必須な操作であるため、短時間で安
全に行えることが望ましく、この様な日常的な操作にお
いて長時間を要することは取扱に不便であるのみならず
、除去操作の時間上の手順が使用者に遵守されないとい
う事態を誘発しやすい。その様な場合、ソフトコンタク
トレンズに過酸化水素の一部が残留し、それが徐々にレ
ンズ外に放出されることから、その様なソフトコンタク
トレンズを装着したとき、レンズ外に徐々に放出される
過酸化水素によって眼に刺激を与え、場合により組織に
障害を与えることもあり得るものと懸念されていた。Among the above methods, in the method of sterilizing soft contact lenses by immersing them in a solution containing hydrogen peroxide at a predetermined concentration for a certain period of time, the specific procedure is to sterilize soft contact lenses by soaking them in a solution containing hydrogen peroxide at a predetermined concentration. The sterilization procedure itself is completed by immersing the soft contact lens in an aqueous solution containing a certain concentration of hydrogen peroxide for usually 10 minutes or more, and then the soft contact lens is removed from the aqueous solution of hydrogen peroxide and treated with a hydrogen peroxide remover (hereinafter referred to as hydrogen peroxide remover). The entire operation was completed by removing the hydrogen peroxide adhering to or penetrating the lens through a immersion process (referred to as a "removal agent"). Examples of removal agents used to remove hydrogen peroxide from soft contact lenses include liquid agents containing sodium thiosulfate, sodium pyruvate, peroxidase, etc. as main components, and metal catalysts. Regardless of the type of hydrogen peroxide, the method of the present invention can be applied to remove hydrogen peroxide. Although treating soft contact lenses with an aqueous hydrogen peroxide solution is an extremely effective method in terms of sterilization effect, on the other hand, regarding the removal of hydrogen peroxide after sterilization, which is essential in this method, soft contact lenses A part of the hydrogen peroxide that has adhered to or permeated the surface of the surface of the surface of the surface of the surface of the surface of the surface of hydrogen peroxide has the drawback that it is difficult to remove it immediately by immersing it in a removing agent. In other words, simply immersing soft contact lenses in a removal agent after sterilization will only gradually remove some of the hydrogen peroxide that has adhered to or permeated the soft contact lenses. Some of the hydrogen peroxide that permeated remains inside the soft contact lens, and it is almost completely removed (for example,
In order to remove less than 1 μg per lens, it was necessary to soak the soft contact lenses in the remover for a long time. Sterilizing soft contact lenses is an operation that must be repeated every day and is essential for hygiene management, so it is desirable to be able to do it safely in a short time, and it is inconvenient to handle such a routine operation if it takes a long time. In addition, it is easy to cause a situation in which the user does not follow the time procedure for the removal operation. In such cases, some hydrogen peroxide remains in the soft contact lenses and is gradually released outside the lens, so when such soft contact lenses are worn, hydrogen peroxide is gradually released outside the lens. There were concerns that the hydrogen peroxide produced by the plant could irritate the eyes and, in some cases, cause tissue damage.
上記の問題点の解決のため鋭意検討を加えた結果、水中
に浸１したソフトコンタクトレンズに超音波を照射する
ことにより残留する過酸化水素の除去が、水中に単に浸
漬することのみによる場合に較べて、著しく促進される
こと、及び水の代わりに除去剤を使用したときにも、超
音波を照射することによって、除去剤に単に浸漬するこ
とのみ似よる場合に較べて、過酸化水素の除去が更に促
進されることを見いだし、本発明を完成した。すなわち
、本発明は、過酸化水素水溶液によって殺菌処理をした
ソフトコンタクトレンズを除去剤に一定時間浸漬すると
いう従来行われていた操作において、除去剤に浸漬した
ソフトコンタクトレンズに超音波を照射することによっ
て、ソフトコンタクトレンズから過酸化水素を極めて迅
速に除去する方法である。本発明は具体的には、過酸化
水素水水溶液により殺菌を終了したソフトコンタクトレ
ンズを常法に従って過酸化水素の除去剤に浸漬する間、
同レンズに超音波を照射するものである。同レンズに超
音波を照射するには、同レンズを浸漬した除去剤自体に
超音波振動子を直接投入して超音波を照射するか、ソフ
トコンタクトレンズと除去剤とを、超音波振動子に直結
して設置された超音波振動をなし得る容器に直接収容し
て超音波を照射するか、あるいは、超音波発生機に付設
された水槽中に水を満たし、これに除去剤とソフトコン
タクトレンズを収容した容器を浸漬して該容器の外側よ
り水槽中の水を介して超音波を照射してもよい。超音波
の周波数としては、この目的には例えば発信周波数が２
０ｋＨｚ乃至６０ｋＨ２の範囲の超音波を発する超音波
振動子が使用できるが、必ずしもこの範囲に限定される
ものではない。また、使用し得る超音波の出力に関して
は、例えば通常卓上で利用されている、容量４００ｍ１
程度の水槽を付設した小型の超音波６し浄器におけると
同程度、すなわち約３ｏｗ（／ｌ！ｌ費電力）迄のもの
でも十分の効果が得られる。また、超音波の照射時間と
しては、３０分以下で、十分な効果が得られる。As a result of intensive studies to solve the above problems, we found that it is possible to remove residual hydrogen peroxide by irradiating ultrasonic waves on soft contact lenses immersed in water, but only by immersing them in water. Compared to the case where only immersion in the remover is similar, even when a remover is used instead of water, ultrasonic irradiation significantly accelerates the removal of hydrogen peroxide. It was discovered that the removal was further promoted, and the present invention was completed. That is, in the conventional operation of immersing a soft contact lens that has been sterilized with an aqueous hydrogen peroxide solution in a removal agent for a certain period of time, the present invention irradiates the soft contact lens immersed in a removal agent with ultrasonic waves. This is a very quick way to remove hydrogen peroxide from soft contact lenses. Specifically, the present invention involves immersing soft contact lenses that have been sterilized with an aqueous hydrogen peroxide solution in a hydrogen peroxide remover according to a conventional method.
The lens is irradiated with ultrasonic waves. To irradiate the lens with ultrasonic waves, you can either directly insert an ultrasonic transducer into the removal agent in which the lens has been soaked and irradiate the ultrasonic wave, or insert the soft contact lens and the removal agent into the ultrasonic transducer. Either place the remover and soft contact lenses directly in a container that can generate ultrasonic vibrations and irradiate them with ultrasonic waves, or fill a tank attached to the ultrasonic generator with water and fill it with the remover and soft contact lenses. A container containing the water may be immersed and ultrasonic waves may be irradiated from the outside of the container through the water in the aquarium. For this purpose, for example, the transmission frequency is 2.
An ultrasonic transducer that emits ultrasonic waves in the range of 0 kHz to 60 kHz can be used, but is not necessarily limited to this range. In addition, regarding the output of ultrasonic waves that can be used, for example, the capacity is 400 m1, which is usually used on a tabletop.
A sufficient effect can be obtained even with the same level as in a small ultrasonic purifier equipped with a water tank, that is, up to about 3 OW (power consumption/l!l). Moreover, sufficient effects can be obtained with ultrasonic irradiation time of 30 minutes or less.
本発明に係る、過酸化水素水溶液によって殺菌処理をし
たソフトコンタクトレンズに除去剤中で超音波を照射す
る、という方法は、後述の実施例に見られる通り、コン
タクトレンズに残留する過酸化水素を、超音波を用いな
いで同様の操作をした場合に較べて、極めて短時間で除
去し得るものである。このことによって、従来の方法に
比較して遥かに短時間の操作で、しかも完全に近く、コ
ンタクトレンズから過酸化水素を除去することが可能で
あるため、過酸化水素によって殺菌処理した後の過酸化
水素の除去の操作に極めて有効かつ簡便である。しかも
、これによって、従来の除去水素が残留し、それが装着
中に徐々にソフトコンタクトレンズの外に放出される、
という事態の発生の可能性も除去され、過酸化水素の水
／８液によってソフトコンタクトレンズを殺菌する日常
の管理操作を安全性の極めて高いものにすることが可能
である。The method of irradiating ultrasonic waves in a remover to soft contact lenses that have been sterilized with an aqueous hydrogen peroxide solution according to the present invention removes hydrogen peroxide remaining in contact lenses, as shown in the examples below. , it can be removed in an extremely short time compared to a similar operation without using ultrasound. This makes it possible to remove hydrogen peroxide from contact lenses in a much shorter time than with conventional methods, and in a nearly complete manner. It is extremely effective and simple to remove hydrogen oxide. Moreover, this leaves conventionally removed hydrogen, which is gradually released out of the soft contact lens during wear.
The possibility of such a situation occurring is also eliminated, and the daily management operation of sterilizing soft contact lenses with a water/8 solution of hydrogen peroxide can be made extremely safe.
（方 法）
１、 率レンズにおける超３°照 の効果し株式
会社製の高含水率レンズであるプレス・オー（商品名）
（＋１８．０ＯＤ）を使用した。
ｌ−１４℃ ：
（１）１４枚のレンズの各１枚づつを、５ｍｌ相当容量
の１４本のガラス製試料瓶に収容した各５ｍＩの３％過
酸化水素を含有する水溶液にそれぞれ浸漬し、室温にて
１０分間放置後、レンズを取り出し表面に付着した過酸
化水素含有水溶液を抗告し、直ちに下記に示す試験操作
に供した。すなわら、これらのレンズのうち、２枚につ
いては直ちにレンズ中の過酸化水素の定量を後述の方法
に従って行い、残りのレンズについては６枚づつの２群
（超音波照射群及び超音波非照射群）に分けた。
超音波照射群においては各２枚を、１枚づつ個別に、５
ｍｌ相当容量のガラス製試薬瓶に収容した各２．５ｍｌ
の蒸留水、下記の除去剤Ｒ１若しくは除去剤Ｒ２（表１
）に浸漬し、該試料瓶を、水温を４°Ｃに調整した水を
収容した２台の超音波洗浄器（ＳＳＣ−３５００：新日
星電子株式会社製）の漕の中央部に３本づつ固定した状
態にて、発信周波数４０ＫＨ２の超音波を照射しく消費
電力３１Ｗ）、照射開始後１０分にてレンズを取り出し
レンズに付着した液を抗告して、直ちにレンズ中の過酸
化水素の定量を行った。超音波非照射群の６枚のレンズ
は超音波照射群と同様に蒸留水、除去剤Ｒ１若しくは除
去剤Ｒ２に浸漬し、４℃に水温を調節した水槽中に試料
瓶ごと浸漬し、１０分後に取り出して、超音波照射群と
同様にレンズ中の過酸化水素の定量を行った。
＜２） １２枚のレンズの各１枚づつを、（１）と同様
に過酸化水素水溶液にて処理し、レンズを取り出し表面
に付着した過酸化水素水溶液、を抗告し、直ちに６枚づ
つの２群（超音波照射群及び超音波非照射群）に分け、
以下、浸漬時間を２０分とした以外は、上記（１）に準
じた操作を行った。
（３）１２枚のレンズを用い、浸漬時間を３０分とした
以外は上記（２） に準じた操作を行った。
−しｇＡ １−２２０℃ ：
（１）水槽の水温を２０’Ｃに調整装した以外は、実施
例ｉ−ｉの（１）に準じた。
（２）水槽の水温を２０°Ｃに調整した以外は、実施例
ｉ−ｉの（２） に準じた。
２、 レンズにおける ３′ の株式会社日
本コンタクトレンズ研究所製の低含水率レンズであるソ
フト３８（商品名）（＋１８゜００Ｄ）を使用した。
一施２−１４℃ ：
（１）１４枚のレンズの各１枚ずつを、５ｍｌ相当容量
の１４本のガラス製試料瓶に収容した各５ｍｌの３％過
酸化水素を含有する水溶液にそれぞれ浸漬し、室温にて
１０分間放置後、レンズを取り出し表面に付着した過酸
化水素水溶液を拭去し、直ちに下記に示す試験操作に供
した。すなわち、これらのレンズのうち、２枚について
は直ちにレンズ中の過酸化水素の定量を行い、残りのレ
ンズについては６枚づつの２群（超音波照射群及び超音
波非照射群）に分けた。超音波照射群においては各２枚
を、１枚づつ個別に、５ｍｌ相当容量のガラス製試薬瓶
に収容した各２．５ｍｌの蒸留水、下記の除去剤Ｒ１若
しくは除去剤Ｒ２に浸漬し、該試料瓶を、水温を４℃に
調整した水を収容した２台の超音波洗浄器（ＳＳＣ−３
５００：新日星電子株式会社製）の槽の中央部に３本づ
つ固定した状態にて、超音波を照射し、照射開始後１０
分にてレンズを取り出しレンズに付着した液を拭去して
、直ちにレンズ中の過酸化水素の定量を行った。超音波
非照射群の６枚のレンズは超音波照射群と同様に蒸留水
、除去剤Ｒ１若しくは除去剤Ｒ２に浸漬し、４℃に水温
を調節した水槽中に試料瓶ごと浸漬し、１０分後に取り
出して、超音波照射群と同様にレンズ中の過酸化水素の
定量を行った。
（２） １２枚のレンズの各１枚づつを、（１）と同様
に過酸化水素水溶液にて処理し、レンズを取り出し表面
に付着した過酸化水素水溶液を拭去し、直ちに６枚づつ
の２群（超音波照射群及び超音波非照射群）に分け、以
下、浸漬時間を２０分とした以外は、上記（１）に準じ
た操作を行った。
（３）１２枚のレンズを用い、浸漬時間を３０分とした
以外は上記（２） に準じた。
（４）上記（１）と並行して、４枚のレンズを過酸化水
素水溶液にて同様に処理したものを１枚づつ個別に、５
ｍｌ相当容量の４個のガラス製試薬瓶に収容した各２．
５ｍｌの除去剤Ｒ２に浸漬し、該試料瓶を、水温を４°
Ｃに調整した水を収容した超音波洗浄器（ＨＯ−１０：
立石電機株式会社製）の槽の中央部に固定した状態にて
、発信周波数４６ Ｋ ＨＺの超音波を照射し、照射開
始後２０及び３０分にてそれぞれ２枚のレンズを取り出
しレンズに付着した液を拭去して、直ちに上記（１）に
準じてレンズ中の過酸化水素の定量を行った。
２−２２０℃ ：
（１）水槽の水温を２０℃に調整型した以外は、実施例
２−１の（１）に準じた。
（２）水槽の水温を２０℃に調整した以外は、実施例２
−１の（２） に準じた。
過酸化フ 、の定量° ：
過酸化水素定量法には硫酸チタン法を用いた。
すなわち、容量５ｍｌのガラス瓶に生理食塩水１ｍｌ及
び硫酸チタン溶液（コード番号： ２０７−０５６７５
：和光純薬株式会社）１滴を加え、これにソフトコンタ
クトレンズ１枚を浸漬して室温にて３０分間震盪した後
、液をマイクロセルに採取して波長４３０ｎｍにおける
吸光度を測定した。
リン酸ニナトリウム ０． ２
０． ２塩化ナトリウム ０．
１ ０． ５リン酸
、 ｓ 、 、
ｓ。
ｐＨ７ｐＨ７
（結 果）
表２から表６に示す通り、使用したレンズの種類、除去
剤の種類、及び設定温度の何れの条件下においても、超
音波の照射により、コンタクトレンズからの過酸化水素
の除去が著しく促進された。
１、 水 レンズにおける超３ 照射の 果表２
実施例１−１； （１）、 （２）、 （３）：レン
ズ中の過酸化水素残存量（μｇ／ｌｒンス′）七°ルピ
ン酸
０．５
ｆオ硫酸ナトリウム
２．５
不；不照射、
照；
超音波照射
ｊ原
２８．７
１０．３
表３
実施例１−２）；
（１）。
レンズ中の過酸化水素残存量
（μ ｇ／レンス゛）
表５
実施例２−１） ； （４） ：
レンズ中の過酸化水素残存量
（μ ｇ／レンス゛）
不；不照射、
照；超音波照射
レンズにおける
の
表６
実施例２−２）；
（１）。
表４
実施例２−１）；
（１）。
（２）。
レンズ中の過酸化水素残存量
（μ ｇ／レンス′）
レンズ中の過酸化水素残存量
（μ ｇ／レンス゛）
蒸留水
不
１４５．１
９９．９
９１．６
照
１３．９
５．７
除去剤Ｒ１
７５，２
５３，７(Method) 1. Press-O (product name), a high water content lens manufactured by Co., Ltd., which has the effect of super 3° illumination in a ratio lens.
(+18.0OD) was used. 1-14°C: (1) One of each of the 14 lenses was immersed in an aqueous solution containing 3% hydrogen peroxide at 5 ml each contained in 14 glass sample bottles with a capacity equivalent to 5 ml, After being left at room temperature for 10 minutes, the lens was taken out, the hydrogen peroxide-containing aqueous solution adhering to the surface was removed, and the lens was immediately subjected to the test operation described below. In other words, for two of these lenses, the amount of hydrogen peroxide in the lenses was immediately determined according to the method described below, and for the remaining lenses, two groups of six lenses each (an ultrasonic irradiation group and an ultrasonic non-irradiation group) were used. irradiation group). In the ultrasound irradiation group, 2 sheets each, 1 sheet each, 5
2.5ml each contained in a glass reagent bottle with a capacity equivalent to ml
distilled water, the following remover R1 or remover R2 (Table 1
), and the sample bottles were placed in the center of two ultrasonic cleaners (SSC-3500: manufactured by Shinnichisei Electronics Co., Ltd.) containing water whose temperature had been adjusted to 4°C. While each lens is fixed, irradiate ultrasonic waves with a transmission frequency of 40 KH2 (power consumption: 31 W). 10 minutes after the start of irradiation, remove the lens and remove the liquid adhering to the lens. Immediately quantify the amount of hydrogen peroxide in the lens. I did it. The six lenses of the ultrasound non-irradiation group were immersed in distilled water and remover R1 or remover R2 in the same way as the ultrasound irradiation group, and the sample bottle was immersed in a water tank whose water temperature was adjusted to 4°C for 10 minutes. Afterwards, the lenses were taken out and hydrogen peroxide in the lenses was quantified in the same manner as in the ultrasound irradiation group. <2) Treat one of each of the 12 lenses with an aqueous hydrogen peroxide solution in the same way as in (1), remove the lens, remove the aqueous hydrogen peroxide solution that adheres to the surface, and immediately treat each of the 6 lenses. Divided into 2 groups (ultrasound irradiation group and ultrasound non-irradiation group),
Hereinafter, the operation according to (1) above was performed except that the immersion time was 20 minutes. (3) The same procedure as in (2) above was performed except that 12 lenses were used and the immersion time was 30 minutes. -ShigA 1-220°C: (1) The same procedure as in Example ii (1) was followed except that the water temperature in the water tank was adjusted to 20'C. (2) The same procedure as in Example ii (2) was followed except that the water temperature in the water tank was adjusted to 20°C. 2. Soft 38 (trade name) (+18°00D), a low water content lens manufactured by Japan Contact Lens Institute Co., Ltd., was used as the 3' lens. 2-14°C: (1) Immerse one of each of the 14 lenses in 5 ml of an aqueous solution containing 3% hydrogen peroxide, each contained in 14 glass sample bottles with a capacity equivalent to 5 ml. After leaving the lens at room temperature for 10 minutes, the lens was taken out, the hydrogen peroxide aqueous solution adhering to the surface was wiped off, and the lens was immediately subjected to the test operation described below. In other words, the hydrogen peroxide in two of these lenses was immediately quantified, and the remaining lenses were divided into two groups of six lenses each (ultrasonic irradiation group and ultrasound non-irradiation group). . In the ultrasonic irradiation group, each two sheets were individually immersed in 2.5 ml of distilled water and the following remover R1 or remover R2 stored in a glass reagent bottle with a capacity equivalent to 5 ml. The sample bottle was cleaned using two ultrasonic cleaners (SSC-3) containing water whose temperature was adjusted to 4°C.
500: Ultrasonic waves were irradiated with three wires fixed at the center of the tank (manufactured by Shinnichisei Electronics Co., Ltd.) for 10 minutes after the start of irradiation.
After a few minutes, the lens was removed, the liquid adhering to the lens was wiped off, and the amount of hydrogen peroxide in the lens was immediately determined. The six lenses of the ultrasound non-irradiation group were immersed in distilled water and remover R1 or remover R2 in the same way as the ultrasound irradiation group, and the sample bottle was immersed in a water tank whose water temperature was adjusted to 4°C for 10 minutes. Afterwards, the lenses were taken out and hydrogen peroxide in the lenses was quantified in the same manner as in the ultrasound irradiation group. (2) Treat one of each of the 12 lenses with an aqueous hydrogen peroxide solution in the same way as in (1). Remove the lens, wipe off the hydrogen peroxide solution adhering to the surface, and immediately treat each of the 6 lenses. They were divided into two groups (ultrasonic irradiation group and ultrasound non-irradiation group), and the following operation was performed in accordance with (1) above, except that the immersion time was 20 minutes. (3) Same as (2) above except that 12 lenses were used and the immersion time was 30 minutes. (4) In parallel with (1) above, 4 lenses were treated in the same way with a hydrogen peroxide aqueous solution, and each lens was individually treated with 5
2.0ml each contained in 4 glass reagent bottles with a capacity equivalent to ml.
Immerse the sample bottle in 5 ml of remover R2 and adjust the water temperature to 4°.
Ultrasonic cleaner (HO-10:
(manufactured by Tateishi Electric Co., Ltd.), irradiated with ultrasonic waves with a transmission frequency of 46 KHz, and 20 and 30 minutes after the start of irradiation, two lenses were taken out and attached to the lenses. Immediately after wiping off the liquid, hydrogen peroxide in the lens was determined according to (1) above. 2-220°C: (1) Same as (1) of Example 2-1 except that the water temperature in the water tank was adjusted to 20°C. (2) Example 2 except that the water temperature in the aquarium was adjusted to 20°C
-1 (2). Determination of hydrogen peroxide: Titanium sulfate method was used for hydrogen peroxide determination. That is, 1 ml of physiological saline and titanium sulfate solution (code number: 207-05675) in a 5 ml glass bottle.
: Wako Pure Chemical Industries, Ltd.) was added, one soft contact lens was immersed in the solution, and after shaking at room temperature for 30 minutes, the liquid was collected into a microcell and the absorbance at a wavelength of 430 nm was measured. Disodium phosphate 0. 2
0. Sodium dichloride 0.
1 0. 5 phosphoric acid
,s, ,
s. pH7pH7 (Results) As shown in Tables 2 to 6, ultrasonic irradiation removes hydrogen peroxide from contact lenses, regardless of the type of lens used, the type of remover used, and the set temperature. Removal was significantly accelerated. 1. Results of super 3 irradiation on water lenses 2
Example 1-1; (1), (2), (3): Residual amount of hydrogen peroxide in lens (μg/lrance') 7°lupic acid 0.5 f Sodium sulfate 2.5 No; No Irradiation; Ultrasonic irradiation 28.7 10.3 Table 3 Example 1-2); (1). Amount of hydrogen peroxide remaining in the lens (μg/lens゛) Table 5 Example 2-1) ; (4): Amount of hydrogen peroxide remaining in the lens (μg/lens゛) No: no irradiation, irradiation: ultrasonic Table 6 Example 2-2) for the irradiation lens; (1). Table 4 Example 2-1); (1). (2). Amount of hydrogen peroxide remaining in the lens (μg/lens') Amount of hydrogen peroxide remaining in the lens (μg/lens') Distilled water 145.1 99.9 91.6 13.9 5.7 Remover R1 75,2 53,7
Claims (1)
タクトレンズを、過酸化水素除去剤中に浸漬することに
より該ソフトコンタクトレンズから過酸化水素を除去す
る方法において、該除去剤中にて該ソフトコンタクトレ
ンズに超音波を照射することを特徴とする、ソフトコン
タクトレンズから過酸化水素を除去する方法。 ２、超音波の周波数が２０ｋＨｚ〜６０ｋＨｚである特
許請求の範囲第１項記載の過酸化水素を除去する方法。 ３、超音波を照射する時間が約３０分以内である特許請
求の範囲第１項又は第２項記載の過酸化水素を除去する
方法。[Claims] 1. A method for removing hydrogen peroxide from a soft contact lens that has been sterilized with an aqueous solution of hydrogen peroxide by immersing the same in a hydrogen peroxide removal agent. A method for removing hydrogen peroxide from a soft contact lens, the method comprising irradiating the soft contact lens with ultrasound in a removal agent. 2. The method for removing hydrogen peroxide according to claim 1, wherein the frequency of the ultrasonic waves is 20 kHz to 60 kHz. 3. The method for removing hydrogen peroxide according to claim 1 or 2, wherein the ultrasonic irradiation time is about 30 minutes or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63308538A JPH02154763A (en) | 1988-12-06 | 1988-12-06 | Method for removing hydrogen peroxide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63308538A JPH02154763A (en) | 1988-12-06 | 1988-12-06 | Method for removing hydrogen peroxide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02154763A true JPH02154763A (en) | 1990-06-14 |
Family
ID=17982233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63308538A Pending JPH02154763A (en) | 1988-12-06 | 1988-12-06 | Method for removing hydrogen peroxide |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH02154763A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59105457A (en) * | 1982-11-23 | 1984-06-18 | ク−パ−・ビジヨン・インコ−ポレ−テツド | Sterilization treatment using hydrogen peroxide and neautralization of residue of said hydrozen peroxide |
| JPS63254416A (en) * | 1987-04-13 | 1988-10-21 | Matsushita Refrig Co | Method for cleaning contact lens |
-
1988
- 1988-12-06 JP JP63308538A patent/JPH02154763A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59105457A (en) * | 1982-11-23 | 1984-06-18 | ク−パ−・ビジヨン・インコ−ポレ−テツド | Sterilization treatment using hydrogen peroxide and neautralization of residue of said hydrozen peroxide |
| JPS63254416A (en) * | 1987-04-13 | 1988-10-21 | Matsushita Refrig Co | Method for cleaning contact lens |
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