JPH01216912A - Hair tonic - Google Patents
Hair tonicInfo
- Publication number
- JPH01216912A JPH01216912A JP4183588A JP4183588A JPH01216912A JP H01216912 A JPH01216912 A JP H01216912A JP 4183588 A JP4183588 A JP 4183588A JP 4183588 A JP4183588 A JP 4183588A JP H01216912 A JPH01216912 A JP H01216912A
- Authority
- JP
- Japan
- Prior art keywords
- hair tonic
- forskolin
- hair
- effect
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000001256 tonic effect Effects 0.000 title claims abstract description 12
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims abstract description 22
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims abstract description 11
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000003795 chemical substances by application Substances 0.000 abstract description 6
- 239000000654 additive Substances 0.000 abstract description 3
- 239000000810 peripheral vasodilating agent Substances 0.000 abstract description 3
- 229960002116 peripheral vasodilator Drugs 0.000 abstract description 3
- -1 stimulant Substances 0.000 abstract description 3
- 229940088594 vitamin Drugs 0.000 abstract description 3
- 229930003231 vitamin Natural products 0.000 abstract description 3
- 239000011782 vitamin Substances 0.000 abstract description 3
- 235000013343 vitamin Nutrition 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 241000207923 Lamiaceae Species 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract description 2
- 239000000645 desinfectant Substances 0.000 abstract description 2
- 239000003906 humectant Substances 0.000 abstract description 2
- 239000003410 keratolytic agent Substances 0.000 abstract description 2
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 230000000694 effects Effects 0.000 description 9
- 235000019441 ethanol Nutrition 0.000 description 5
- 235000015961 tonic Nutrition 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 230000003779 hair growth Effects 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
- 241000208293 Capsicum Species 0.000 description 3
- 235000002566 Capsicum Nutrition 0.000 description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000001390 capsicum minimum Substances 0.000 description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 229940098465 tincture Drugs 0.000 description 3
- 229940042585 tocopherol acetate Drugs 0.000 description 3
- 229960000716 tonics Drugs 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 229940041616 menthol Drugs 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 229960004889 salicylic acid Drugs 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 244000184734 Pyrus japonica Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 239000001685 glycyrrhizic acid Substances 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000003658 preventing hair loss Effects 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明はフォルスコリンを有効成分とする養毛剤に間す
る。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a hair nourishing agent containing forskolin as an active ingredient.
センブリエキス、ビタミンＥアセテート等の末梢血管拡
張剤やトウガラシチンキ等の刺激剤は従来から、養毛剤
の成分として用いられてきた。Peripheral vasodilators such as Oriental japonica extract and vitamin E acetate, and stimulants such as capsicum tincture have been used as ingredients of hair tonics.
従来知られている養毛剤は、その効果の不十分なものが
多く、新たな有効成分の出現が期待されている。Many of the conventionally known hair nourishing agents have insufficient effects, and the emergence of new active ingredients is expected.
そこで本発明者らは種々検討した結果、フォルスコリン
が養毛剤の有効成分として有用であることを見い出した
。As a result of various studies, the present inventors have discovered that forskolin is useful as an active ingredient in hair tonics.
本発明は上記知見に基づき完成されたものである。フォ
ルスコリンはシソ科植物Ｃｏ１ｅｕｓｆｏｒｓｋｏｈｌ
ｉ ｉの機中から見い出された既知の化合物である（
テトラヘドロン レター １６６９−１６７２ （１９
７７））。The present invention has been completed based on the above findings. Forskolin is a plant of the Lamiaceae family, Coleusforskohl.
It is a known compound found in the aircraft of ii (
Tetrahedron Letter 1669-1672 (19
77)).
本発明の養毛剤におけるフォルスコリンの配合量は、約
０．００１〜６重量％程度、好ましくは０．１〜２．０
重量％程度である。The amount of forskolin in the hair growth agent of the present invention is approximately 0.001 to 6% by weight, preferably 0.1 to 2.0% by weight.
It is about % by weight.
本発明の養毛剤にはフォルスコリンのほか、通常養毛剤
に用いられる添加剤、例えば末梢血管拡張剤（ビタミン
Ｅアセテート、センブリエキス等）、刺激剤（トウガラ
シチンキ等）、ビタミン類（ビタミンＥ−Ｂ２、Ｂ６、
ビオチン、イノジット、パントテン酸、パントテニール
アルコール、ニコチン酸アミドなど）
〔実施例〕
フォルスコリン ０．５ｇ
ビタミンＥアセテート ０．１ ｇ
トウガラシチンキ 適量
グリチルリチン酸 ０．０５ｇ
サリチル酸 ０．０１ｇ
メントール ０．０１ｇ
グリセリン １．０ ｇ
エタノール ７０ｇ
香料 適量
蒸留水 ２８．３２ｇ
総計 １００ｇ
上記各成分を混合、均一に溶解して溶液剤を得た。In addition to forskolin, the hair tonic of the present invention includes additives normally used in hair tonics, such as peripheral vasodilators (vitamin E acetate, Japanese thorns extract, etc.), stimulants (capsicum tincture, etc.), and vitamins (vitamin E-B2, B6,
Biotin, Inosit, pantothenic acid, pantothenyl alcohol, nicotinic acid amide, etc.) [Example] Forskolin 0.5g Vitamin E acetate 0.1g Capsicum tincture Appropriate amount Glycyrrhizic acid 0.05g Salicylic acid 0.01g Menthol 0.01g Glycerin 1 0 g Ethanol 70 g Perfume Appropriate amount Distilled water 28.32 g Total 100 g The above components were mixed and uniformly dissolved to obtain a solution.
７５％エタノールにフォルスコリンを０．５Ｗ／Ｖ％添
加溶解した試料を用い次の実験を行った。The following experiment was conducted using a sample prepared by adding and dissolving 0.5 W/V% forskolin in 75% ethanol.
１、本養毛剤の皮膚への影響を調べるため、１日２回、
消炎剤（塩酸ジフェンヒドラミン、グリチルレチン酸、
グリチルリチンなど）、角質溶解剤（乳酸、レゾルシン
、サリチル酸など）、殺菌剤（イソプロピルメチルフェ
ノール、塩酸アルキルジアミノエチルグリシン液、パラ
クロルメタキシレノール、第四級アンモニウム塩など）
、清涼剤（メントール、カンファーなど）、湿潤剤（グ
リセリン、プロピレングリコール、１．３−ブチレング
リコール、ソルビトール、ピロリドンカルボン酸ナトリ
ウム、ムコ多糖類など）なとのほかアルコール（エチル
アルコール、ベンジルアルコール、フェネチルアルコー
ルなど）、油性分（オリーブオイル、スクワランなど）
、色素、香料、界面活性剤、高分子（カルボキシビニル
ポリマー、ポリビニルアルコール、メチルセルロースな
ど）、水などをさらに配合することができる。また剤型
的には、ローションタイプ、ゲル、ゲル状クリーム、ク
リーム、乳液などいずれでもよい。1. To investigate the effect of this hair tonic on the skin, twice a day.
Anti-inflammatory agents (diphenhydramine hydrochloride, glycyrrhetinic acid,
glycyrrhizin, etc.), keratolytic agents (lactic acid, resorcinol, salicylic acid, etc.), disinfectants (isopropylmethylphenol, alkyldiaminoethylglycine hydrochloride solution, parachlormetaxylenol, quaternary ammonium salts, etc.)
, cooling agents (menthol, camphor, etc.), humectants (glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, sodium pyrrolidone carboxylate, mucopolysaccharide, etc.), and alcohols (ethyl alcohol, benzyl alcohol, phenethyl alcohol, etc.). alcohol, etc.), oil-based ingredients (olive oil, squalane, etc.)
, pigments, fragrances, surfactants, polymers (carboxyvinyl polymer, polyvinyl alcohol, methyl cellulose, etc.), water, etc. can be further blended. In terms of dosage form, it may be of any type, such as lotion type, gel, gel-like cream, cream, or milky lotion.
本発明の養毛剤は有効成分のほかに適当量の上記した添
加剤を、それ自体公知の方法またはそれに準する方法に
より製造することができる０通常は上記の所要成分を混
合することによって製造することができる。このように
して製造した組成分は朝晩各１回約１〜６ｇづつ頭皮ま
たは頭髪にふりかけ手指などで塗擦することにより使用
することができる。The hair growth agent of the present invention can be manufactured by adding an appropriate amount of the above-mentioned additives in addition to the active ingredients by a method known per se or a method similar thereto.Normally, it can be manufactured by mixing the above-mentioned required ingredients. Can be done. The composition prepared in this manner can be used by sprinkling about 1 to 6 g of the composition on the scalp or hair once in the morning and evening and rubbing it in with fingers or the like.
１回当り５０μ９の試料を３週間、マウスの皮膚に塗布
したが、とくに悪い影響は認められなかった。A sample of 50 μ9 per dose was applied to the skin of mice for 3 weeks, but no particular adverse effects were observed.
２、 ＩＩ毛作用、脱毛防止作用を確認するため、８
名の壮年性脱毛症の男性（３８〜５８才）に朝夕１日２
回、適量を６ケ月間頭皮に塗布した。作用の評価の仕方
は写真と本人の自覚症状を併用した。その結果、写真で
発毛効果のあった者 ３名 フケ、かゆみがなくなった
者 ２名 であり、従って、症状の改善のあったものは
８名中５名であった。2. II To confirm the hair effect and hair loss prevention effect, 8
Two times a day, morning and evening, for men (38 to 58 years old) with middle-aged alopecia.
Apply an appropriate amount to the scalp once for 6 months. Effects were evaluated using both photographs and the patient's subjective symptoms. As a result, 3 people showed a hair growth effect and 2 people had no dandruff or itching as seen in the photos.Therefore, 5 out of 8 people showed improvement in their symptoms.
以上から明らかなように、フォルスコリンはすぐれた裏
毛効果を発揮するもので、新たな養毛剤として期待され
る。As is clear from the above, forskolin exhibits an excellent fleece effect and is expected to be used as a new hair growth agent.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4183588A JPH01216912A (en) | 1988-02-26 | 1988-02-26 | Hair tonic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4183588A JPH01216912A (en) | 1988-02-26 | 1988-02-26 | Hair tonic |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH01216912A true JPH01216912A (en) | 1989-08-30 |
Family
ID=12619320
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4183588A Pending JPH01216912A (en) | 1988-02-26 | 1988-02-26 | Hair tonic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01216912A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR970032805A (en) * | 1995-12-07 | 1997-07-22 | 다카하시 미치나오 | Parenting |
| US6333057B1 (en) * | 1995-07-03 | 2001-12-25 | Wilson T. Crandall | Composition and method for topical treatment of androgenic alopecia |
| JP2009298787A (en) * | 2008-06-06 | 2009-12-24 | Lvmh Recherche | Method for anti-aging cosmetic care by stimulation of survivin expression |
| JP2011084523A (en) * | 2009-10-16 | 2011-04-28 | Nicca Chemical Co Ltd | Fibroblast growth factor-7 production promoter, and scalp/hair cosmetic, food and drink containing the same |
| GB2489206A (en) * | 2011-03-14 | 2012-09-26 | James Terence Fletcher | A pharmaceutical composition comprising forskolin and sodium cholate |
| JP2015083571A (en) * | 2014-11-21 | 2015-04-30 | 日華化学株式会社 | Fibroblast growth factor-7 production promoter, and cosmetic for scalp and hair and food and drink containing same |
-
1988
- 1988-02-26 JP JP4183588A patent/JPH01216912A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6333057B1 (en) * | 1995-07-03 | 2001-12-25 | Wilson T. Crandall | Composition and method for topical treatment of androgenic alopecia |
| KR970032805A (en) * | 1995-12-07 | 1997-07-22 | 다카하시 미치나오 | Parenting |
| JP2009298787A (en) * | 2008-06-06 | 2009-12-24 | Lvmh Recherche | Method for anti-aging cosmetic care by stimulation of survivin expression |
| JP2011084523A (en) * | 2009-10-16 | 2011-04-28 | Nicca Chemical Co Ltd | Fibroblast growth factor-7 production promoter, and scalp/hair cosmetic, food and drink containing the same |
| GB2489206A (en) * | 2011-03-14 | 2012-09-26 | James Terence Fletcher | A pharmaceutical composition comprising forskolin and sodium cholate |
| JP2015083571A (en) * | 2014-11-21 | 2015-04-30 | 日華化学株式会社 | Fibroblast growth factor-7 production promoter, and cosmetic for scalp and hair and food and drink containing same |
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