JPH0113862B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Field of Industrial Application] The present invention relates to a microsyringe suitable for injecting a small amount of a medicinal solution of a physiologically active substance such as calcitonin or prostaglandin.

[Conventional technology]

For example, when a medicinal solution containing a physiologically active substance such as calcitonin or prostaglandin is injected into the human body, the required injection amount is extremely small (1 to 10 microns). This type of drug injection has been carried out using, for example, a piston-type syringe that is removably inserted into a cylinder having an injection needle at its tip. however,
In the case of such a syringe, the syringe itself and the needle diameter of the syringe are large (500 to 2500 μ), so
It is impossible to inject a small amount of
It had to be diluted and increased to about 1 ml, and the large needle diameter caused pain under the skin during injection. Also, when inserting a needle subcutaneously, etc., use the fingertips of the other hand not holding the syringe to stretch and expand the patient's skin at the site where the injection is to be made, making it easier for the needle to penetrate. It was a hassle because I had to do it.

Furthermore, when inserting the needle of a hypodermic needle into the human body, the needle is inserted 0.5 to 3 cm deeper than the desired injection site, as doctors and others have the experience to ensure that the needle is inserted to an appropriate depth.

[Problem that the invention seeks to solve]

In this way, it differs slightly depending on subcutaneous, intradermal, or intramuscular injection, but in general, the injection is inserted 0.5 to 3 cm deeper than the injection site, which can damage the vascular system, nervous system, subcutaneous tissue, etc., and even cause damage to the thigh. This was extremely dangerous, as it could cause intramuscular drug-induced injuries such as quadriceps muscle restriction syndrome.

As a result of our youthful research to solve the various conventional problems mentioned above, the present inventors have developed a syringe for the purpose of microinjecting physiologically active substances such as calcitonin and prostaglandin. succeeded in developing it.

The object of the present invention is to be able to inject a minute amount (1 to 10 microns) of a medicinal solution containing a physiologically active substance subcutaneously or intradermally in an almost painless manner, and to ensure that there is no risk of chemical damage such as injury or destruction of the subcutaneous tissue. An object of the present invention is to provide a micro syringe that can prevent

[Means for solving problems]

The means of the present invention for solving the various problems described above includes a liquid medicine container having an internal volume of 1 to 100μ on the upper part of a support plate, a pressing body for pushing out a specified amount of liquid medicine in the liquid medicine container, and a support plate. Provided is a microsyringe comprising a syringe needle with a diameter of 10 to 100μ attached to the lower part of the support plate at an angle of 45° to 90° with respect to the support plate and communicating with the inside of the drug solution container. There is something to do. Furthermore, the present invention provides a
A liquid medicine container having an internal volume of ~10μ, a pressing member for pushing out a specified amount of liquid medicine in the liquid medicine container, and a presser body at the bottom of the support plate, which has an angle of 45° to 90° with respect to the support plate and has the above-mentioned shape. A microsyringe comprising a 10 to 100 μm injection needle attached to communicate with the inside of a drug solution container, and a skin-covered body made of sponge, rubber, or similar elastic material that surrounds the injection needle while maintaining a certain space. is to provide.

[Effect]

One edge of the support plate is pressed near the skin surface to be injected, and the other side edge of the support plate is moved toward the skin surface. The skin surface to be injected is then stretched.
Under this skin condition, the support plate is brought closer to the skin surface and the needle of the ultra-fine injection needle provided on the support plate is inserted subcutaneously or intradermally. Therefore, according to the syringe of the present invention, there is no need for troublesome operations such as pushing the skin surface to be injected with a fingertip to make it easier for the needle to enter.

Hereinafter, several embodiments of the present invention will be described in detail, but the present invention is not limited thereto.

Structure of the first embodiment The syringe 1 according to the invention shown in FIGS. 1 to 3 includes a support plate 2. The support plate 2 is formed into a circular shape by, for example, a metal material, a synthetic resin material, or a similar material. The support plate 2 is
For example, the diameter is 1 to 2 cm and the thickness is 2 to 5 mm, which is an easy-to-handle size. The support plate 2 does not necessarily have to be formed into a circular shape as in this example, but can be formed into, for example, a square shape, an elliptical shape, or any other arbitrary shape. At the center of support plate 2, a diameter of 0.05
A communication hole 3 of ~0.1 mm is formed. A mounting recess 4 is formed in the lower surface of the support plate 2. Syringe needle 5
The end 7 on the opposite side of the barb 6 is directly inserted into the flow hole 3 and fixed. Of course, this attachment is not limited to insertion only, but can be accomplished by other suitable means. The injection needle 5 is made of a metal material such as stainless steel or a synthetic resin material, and has a diameter of 10 to 100 μm and a length of 1 to 5 mm.
It is formed into micro needles. It is important to note that when attaching the injection needle 5 to the support plate 2, the injection needle 5 should be placed at an angle of 45° or more with respect to the lower surface of the support plate 2.
Preferably, they are mounted at an angle of 60° to 90°. Because the injection needle 5 has such an angle and is formed into an extremely thin structure of 10 to 50μ, the needle 6 of the injection needle 5 can penetrate the skin without causing any pain to the skin surface. It makes a sharp cut on the surface and smoothly penetrates into the skin or subcutaneously.

A chemical solution container 8 is provided on the upper surface of the support plate 2, surrounding the communication hole 3. The drug solution container 8 has 1 to
It is formed to a size that can accommodate a 10 μm drug solution, and therefore, a certain amount of a solution of a physiologically active substance such as calcitonin or prostaglandin is accommodated in this drug solution container 8 . A piston rod 9 is inserted into the chemical liquid container 8, and a piston 10 made of an elastic material such as silicone rubber is attached to the tip of the piston rod 9. The piston 10 is prevented from separating from the liquid medicine container 8 by a stopper piece 11 formed at the opening edge of the liquid medicine container 8. piston rod 9
is a pressing body 12 made of metal material or synthetic resin material.
It is formed integrally with. In addition,. In the figure,
Reference numeral 13 is a cover and stopper. This stopper 13 has an opening formed by cutting out a portion thereof in the axial direction. This opening is slightly larger than the outer diameter of the chemical liquid container 8. Therefore,
The chemical solution container 8 can be inserted and removed from this opening without any trouble.
A cover/stopper 13 is removably disposed between the support plate 2 and the pressing body 12.

Next, the use of the syringe will be explained. First of all,
The cover/stopper 13 is removed from between the support plate 2 and the pressing body 12, and the pressing body 12 is pushed downward in FIG. Then, the needle 6 of the injection needle 5 is inserted into a vial or the like containing a physiologically active substance container, and the press plate 12 is pulled up in the opposite direction. Then, the piston 10 fills a certain amount of the medicinal solution into the medicinal solution container 8 through the injection needle 5.

Therefore, in order to actually inject subcutaneously or intradermally into the human body, one end edge of the support plate 2, that is, the edge 2a side toward which the needle 6 of the injection needle 5 is directed, should be used to inject the skin surface 14. Press it close to the desired area (see Figure 2). Using this pressed position as a fulcrum, the other edge 2b side of the support plate 2 is brought closer to the skin surface 14 (see FIG. 3). Then, one end edge 2a of the support plate 2
As a result, the skin surface 14 is stretched further outward than the one end edge 2a.

Therefore, the part of the skin surface 14 to be injected is covered with the skin, and the injection needle 5 maintains an appropriate inclination angle.
The barb 6 scratches the skin surface 14 and is smoothly inserted subcutaneously or intradermally. At the same time, by smoothly pressing the pressing body 12 and pushing the piston 10 into the drug solution container 8, the drug solution container 8
The medicinal solution inside may be allowed to flow out from the flow hole 3 and injected subcutaneously or intradermally through the injection needle 5. Since the injection needle 5 is attached to the support plate 2 at an appropriate angle of inclination, when one edge 2a of the support plate 2 is centered and the other edge 2b approaches the skin surface 14, The thorn portion 6 is pierced into the skin surface 14 from an oblique direction.

Therefore, the injection needle 5 is at most 3 mm (actually 1 to 2 mm) or less of the epidermis, and there is no risk of it penetrating deeper into the skin than necessary, making it extremely safe to use. In addition, in the above case, the condition in which the ultra-fine injection needle 5 arranged diagonally is inserted subcutaneously from an oblique direction while the skin surface to be injected is stretched by the support plate 2 is the same as when a "mosquito" sucks blood. The sensation is similar to that of first pressing down on the skin with your legs to make it stretch, and then inserting a very fine, sharp needle under the skin.
Pain is almost non-existent.

Next, the syringe according to the embodiment shown in FIG. 4 is almost the same as the syringe according to the embodiment shown in FIG. and have the same diameter. Therefore, the shape of the piston 10 inserted into this chemical liquid container 8 is different from that of the embodiment shown in FIG. Of course, the chemical liquid container 8 is 1
The size is selected so that it can be filled with ~10μ of chemical liquid. Further, the operation of the syringe in this embodiment is the same as that of the syringe shown in FIG. 1, so a description thereof will be omitted. The syringe according to the embodiment shown in FIG. 5 is almost the same as the syringe according to the embodiment shown in FIG. It is located on one end edge 2a side of the support plate 2 and is attached at an inclination angle of 80 to 90 degrees.

In the syringe of the embodiment shown in FIG. 6, a skin covering 15 made of sponge, rubber, flexible synthetic resin, or similar material is provided on the support plate 2 so as to surround the injection needle 5. The structure is different from that of the embodiment shown in FIG. The skin covering body 15 is
It is desirable that the cross-sectional shape is widened toward the end, that is, the cross-sectional shape is truncated. However, when injecting, by bringing the skin covering body 15 into contact with the skin surface 14 and pressing the pressing body 12, the skin surface of the area to be injected is stretched by the elastic force of the skin covering body 15, and the injection needle 5 is not inserted. The portion 6 is inserted smoothly under the skin as in the embodiment shown in FIG. The above skin covering 15 may have a structure in which slits are provided at appropriate intervals in the circumferential direction of the skin covering to further improve its elasticity.

The syringe according to the embodiment shown in FIG. 7 differs from the syringe according to the embodiment shown in FIG. 1 in that the injection needle 5 and liquid medicine container 8 are integrated and a skin cover 15 is provided. That is, the skin covering 15 is made of a metal material, a hard synthetic resin material, or a similar material. The skin cover 15 is formed into a hollow cylindrical shape, and is attached so that its upper edge is flush with the upper surface of the support plate 2. An injection needle 5 having an integral drug solution container 8 at its upper end is inserted into the skin covering 15 with a slight space. The drug solution container 8 is
The cross section is roughly dish-shaped, and a piston 10 and a piston rod 9 having the same structure as the embodiment shown in FIG. 1 are fitted into the chemical liquid container 8. The piston rod 9 is integrated with the pressing body 12.
The injection needle of this example is approximately parallel to the lower surface of the support plate 23.
Make a 90° angle. A cover/stopper 13 is removably disposed between the support plate 2 and the pressing body 12 as in the embodiment shown in FIG. A gap 16 of approximately 2 mm is formed between the upper surface and the chemical liquid container 8. Therefore, in this case, the tip of the barb 6 of the injection needle 5 is positioned slightly inward from the lower end opening of the skin cover 15.

When injecting, the cover/stopper 13 is removed from between the support plate 2 and the presser 12, and the lower opening edge of the skin covering 15 is pressed against the skin surface 14. on the other hand,
The lower end edge of the drug solution container 8 is supported on the upper surface of the support plate 2, and the barbs 6 protrude from the skin cover 15.

Therefore, if a pressing force is applied to the pressing body 12,
The needle 6 of the injection needle 5 is inserted subcutaneously and the liquid is injected, as in each of the above embodiments. Although the above embodiment describes the case where the skin covering body 15 is fixed to the support plate 2, a structure may be adopted in which the support plate 2 and the skin covering body 15 are relatively movable.

Furthermore, to explain the embodiment shown in FIG. 8, in this embodiment, the support plate 2, the communication hole 3
The injection needle 5 has the same structure as the embodiment shown in FIG. 1 above. A hemispherical chemical liquid container 8 is attached to the upper surface of the support plate 2 so as to surround the flow hole 3 . The chemical liquid container 8 is made of a synthetic resin material such as polypropylene, and has an internal volume of
1 to 10μ, similar to the drug solution container 8 shown in FIG.
It is sized to accommodate 100 ml of chemical solution. A dome-shaped pressing body 12 surrounding the hemispherical drug solution container 8 is attached to the upper surface of the support plate 2 . The dome-shaped elastic body of this pressing body 12 holds gas, usually air. This pressing body 12 is made of an elastic material such as synthetic resin or rubber. Reference numerals 17 and 18 are covers, which have a hemispherical cross-section. The opening edges of the covers 17 and 18 are removably attached to engagement recesses formed on the upper and lower surfaces of the support plate 2. In the above case, since the air in the press plate 12 attached to the upper surface of the support plate 2 surrounding the drug solution container 8 is not injected into the living body, there is no need to fill it with clean air. The air in the pressing body 12 is used simply to pressurize the outer surface of the liquid medicine container 8. Therefore, for example, after forming the liquid medicine container 8 on the support plate 2, the air inside the pressing body 12 is used to surround the liquid medicine container 8. The press body 12 may be brought into close contact with the press body 12 while containing air.

To fill the syringe with medical solution, cover 17,1
8 from the support plate 2. Next, the support plate 12 is pressed toward the upper surface of the support plate 2 to pressurize the chemical solution container 8 . Under this condition, when the injection needle 5 is inserted into a vial or the like and the pressure on the pressure plate 12 is released, the pressure inside the liquid medicine container 8 becomes negative due to the restoration of the pressure plate 12 and the liquid medicine container 8, and the liquid medicine flows into the injection needle. sucked in through. Next, in order to perform injection, as explained in the case of the syringe shown in FIG. The other end edge 2b of the support plate 2 is brought close to the skin surface 14, the needle 6 of the injection needle 5 is inserted subcutaneously, and the entire press plate 12 is pushed toward the center. Then, the chemical liquid container 8 becomes
The medicinal solution in the container is injected subcutaneously by being compressed by the gas present in the dome-shaped elastic body under pressure from its entire circumferential surface.

Furthermore, as a modification of the embodiment shown in FIG. 8, it is also possible to construct the device as shown in FIG. 9. In this embodiment, the pressing body 12 for pushing out the chemical liquid is formed into a dome-like solid shape made of an elastic material such as sponge, rubber, or the like. Of course, a slight gap is formed between the pressing body 12 and the outer peripheral surface of the liquid medicine container 8. Therefore, in the case of this embodiment, when the pressing body 12 is pressurized, the pressing force is applied to the outer peripheral surface of the liquid medicine container 8, and the pressing body 12 is deformed by pressure in the direction of the gap. Therefore, the chemical liquid container 8 is pressed and liquid injection is performed.

As explained in detail above, the present invention provides 10~
A syringe needle with a diameter of 100μ is installed on the underside of the support plate at an angle of inclination of 45° to 90°, and this injection needle is installed on the upper side of the support plate to inject a drug solution with an internal volume of 1 to 10μ. To communicate with the inside of the container and inject a specified amount of the drug solution in the drug solution container, first, the skin surface to be injected is covered with a support plate, and under the skin, the solution is injected subcutaneously with an ultra-fine injection needle. It is. Therefore, according to the syringe of the present invention, there is no need for troublesome operations such as pushing the skin surface to be injected with each fingertip to make it easier for the needle to enter. Also, the syringe needle is 10~
Because it is extremely thin with a diameter of 100μ, it can be inserted subcutaneously or intradermally with almost no pain.Furthermore, the needle is not inserted more than necessary, which can cause intramuscular drug damage. There is no risk of this happening and it is extremely safe to use. Furthermore, the chemical solution is also 1~
There is no risk of over-injecting as it is contained in a 10μ container. In particular, since it is structurally simple and compact, it can be provided at low cost, which is economically advantageous, and it can be used in a disposable manner. Further, as explained above, the syringe of the present invention poses no danger when injecting liquid, so that patients can easily inject liquid at home. This has the advantage of eliminating the need to go to the hospital every day to receive injections, as was the case up until now.

In addition, the main part of the syringe of the present invention is 10 to 100μ.
Various modifications and changes can be made to the detailed structure of the embodiments as long as the structure includes a syringe needle with a diameter of 1 to 10 μm and a liquid medicine container with an internal volume of 1 to 10 μm.

[Brief explanation of drawings]

The drawings show several embodiments of the present invention, and FIG. 1 is an enlarged sectional view of a syringe according to the first embodiment, FIGS. 4 is an enlarged sectional view of the syringe according to the second embodiment, FIG. 5 is an enlarged sectional view of the syringe according to the third embodiment, FIG. 6 is an enlarged sectional view of the syringe according to the fourth embodiment, and FIG. FIG. 8 is an enlarged sectional view of the syringe according to the sixth embodiment, and FIG. 9 is an enlarged sectional view of the syringe according to the seventh embodiment. Explanation of the symbols: 2 is a support plate, 2a is one edge of the support plate, 2b is the other edge of the support plate, 5 is an injection needle, 6 is a barb, 8 is a drug container, 9 is a piston rod, 10 is a piston, 12 is a The pressure plate, 14 is a skin surface, and 15 is a skin covering.

Claims (1)

[Scope of Claims] 1. A liquid medicine container having an internal volume of 1 to 10 μm on the upper part of the support plate, a pressing body for pushing out a specified amount of the medicine in the liquid medicine container, and a presser body on the lower part of the support plate, which presses against the support plate. A microsyringe comprising a syringe needle having a diameter of 10 to 100 μ and attached at an angle of 45° to 90° and communicating with the inside of the drug solution container. 2. The chemical liquid container is cylindrical, and the pressing body that pushes out a specified amount of the chemical liquid in the chemical liquid container includes a piston that is slidably fitted into the chemical liquid container, and a pressing plate that is attached to the piston via a piston rod. A microsyringe according to claim 1, comprising: 3. The microsyringe according to claim 1, wherein the drug solution container provided on the upper part of the support plate is made of an elastic material. 4. The microsyringe according to claim 3, wherein the drug solution container made of an elastic material has a hemispherical cross section. 5. A dome-shaped pushing body that pushes out a prescribed amount of a drug solution in a drug solution container made of an elastic material contains gas present in a dome-shaped elastic body that surrounds the drug solution container and is attached to the upper part of a support plate. The microsyringe according to claim 3, which is made of an elastic body. 6. A dome-shaped solid elastic body that is attached to the upper part of the support plate so that the pressing body that pushes out a specified amount of drug solution in a drug solution container made of an elastic material surrounds the drug solution container with a small distance therebetween. A microsyringe according to claim 3 consisting of: 7. A liquid medicine container with an internal volume of 1 to 10 μm on the upper part of the support plate, a presser body for pushing out a prescribed amount of liquid medicine in the liquid medicine container, and a pressure body on the lower part of the support plate at an angle of 45° to 90° with respect to the support plate. A 10 to 100μ injection needle installed at an angle so as to communicate with the inside of the drug solution container, and a skin covering made of sponge, rubber, or similar elastic material that surrounds the injection needle with a certain amount of space. A micro syringe equipped with. 8. The microsyringe according to claim 8, wherein the skin-covered body is formed into a sleeve shape from a metal material, hard paper, or hard synthetic resin material. 9. The microsyringe according to claim 8, wherein the sleeve-like skin-covered body is attached to be slidable relative to the support plate. 10. The microsyringe according to claim 7, wherein the drug solution container provided on the upper part of the support plate is made of an elastic material. 11. The microsyringe according to claim 10, wherein the drug solution container made of an elastic material has a hemispherical cross section. 12 A drug solution container made of an elastic material and a pushing body that pushes out a specified amount of drug solution stored in the drug solution container are present in a dome-shaped elastic body that surrounds the drug solution container and is attached to the upper part of the support plate. Claim 10, which is a dome-shaped elastic body containing a gas that
Microsyringe as described in Section. 13. A pressing body that pushes out a prescribed amount of drug solution in a drug solution container made of an elastic material is a dome-shaped solid elastic body attached to the top of the support plate so as to surround the drug solution container with a slight gap. 11. A microsyringe according to claim 10.