JPH0853331A - Tooth powder composition - Google Patents

Abstract

PURPOSE:To obtain a tooth powder composition effective for prevention of dental caries and having properties stable with time. CONSTITUTION:This tooth paste composition is prepared by blending (C) a stabilizer composed of one or more substances selected from (C1): a polyethylene glycol preferably having 300 to 600 polymerization decree and (C2): a vitamin E derivative, preferably tocopherol nicotinate or tocopherol acetate with tooth powder composed of (A) hydroxyapatite preferably having <=1 to 50mum, especially 3 to 30mum average particle diameter and <=100m<2>/g specific surface area and (B) a soluble fluoride, preferably sodium monofluoro-phosphate, sodium fluoride or tin fluoride. The mixture ratio of the respective components is as follows; (A)=1 to 50wt.%, preferably 3 to 10wt.% (C1)=1 to 20wt.% (C2)=0.01 to 1wt.%, (C1):(A)=1:0.5 to 1:50 (C2)(A)=1:1 to 1:1000, respectively on weight base.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dentifrice composition, and more particularly to a dentifrice composition which is effective in preventing dental caries and has stable properties over time.

[0002]

[Prior Art and Problems] Hydroxyapatite is
To remove dental plaque that causes dental caries without damaging the tooth surface and to promote remineralization of the tooth and strengthen the tooth (Registered 1553266, JP-A-56-73014, Registered 1557631),
It is also necessary to adsorb and remove halitosis components in the oral cavity (Japanese Patent Laid-Open No. 4-23
It has been reported to have various effects such as that of [0315), and it is widely known to incorporate this into a dentifrice composition.

Hydroxyapatite readily reacts with other compounds, for example, when soluble fluoride is present in the composition at the same time, fluoride ions may be present in the composition before they act on the hydroxyapatite of the tooth enamel. It is known that it reacts with hydroxyapatite to form fluoroapatite, and it is no longer a fluorine compound that works effectively. In order to overcome such a problem, for example, in JP-A-2-31049, at least one of hydroxyapatite and fluoride is microencapsulated or coated to avoid direct contact with each other. In addition, in the same way,
In the above, the hydroxy group existing on the surface of hydroxyapatite is pretreated with a specific substance to avoid direct contact with each other and suppress the reaction with the soluble fluoride. Further, in Japanese Patent Laid-Open No. 3-193726, loss of effective fluoride is reduced by adjusting the pH of the oral composition containing hydroxyapatite and soluble fluoride to 7.0 to 11.0.

[0004]

However, a toothpaste containing hydroxyapatite and a soluble fluoride causes rough skin when left at a particularly high temperature for a long period of time, or when a rapid temperature change occurs, and when it is severe, It was found that there is a problem in that the solidification occurs and the usability is significantly impaired. The problem of this solidification has not been touched in the conventional technology at all, and for example, it has not been solved by the method disclosed in JP-A-3-93726, and the properties of toothpaste containing hydroxyapatite and soluble fluoride with the passage of time have not been resolved. And there was a need to resolve a cosmetic issue.

[0005]

Means for Solving the Problems As a result of intensive studies to solve such problems, the present inventors have found that the stabilizer contains at least one selected from polyethylene glycol and vitamin E derivatives. , Hydroxyapatite and soluble fluoride are both stably mixed,
It is possible to obtain a dentifrice composition having stable properties and appearance,
The present invention has been completed.

Polyethylene glycol, which is a stabilizer used in the present invention, has a degree of polymerization of 300 to 600 is suitable, and those having a degree of polymerization of less than 300 have an insufficient water retention capacity and the degree of polymerization exceeds 600. Since they are solids, they have poor compatibility with other components. Further, the content is preferably 1 to 20%, and if the content is less than 1%, it is insufficient for stabilizing the properties and appearance, and 20%.
If it exceeds, the usability will deteriorate. Furthermore, the weight ratio of polyethylene glycol and hydroxyapatite is 1: 0.
The ratio of 5 to 1:50 is particularly preferable for stabilizing the properties and appearance.

The vitamin E derivative which is a stabilizer used in the present invention is preferably tocopherol nicotinate or tocopherol acetate, and tocopherol nicotinate is particularly preferred. Moreover, the compounding quantity is 0.0
1 to 1% is preferable, and if the blending amount is less than 0.01%, it is insufficient for stabilizing properties and appearance. Furthermore, when the weight ratio of the vitamin E derivative and hydroxyapatite is 1: 1 to 1: 1000, it is particularly preferable for stabilizing the properties and appearance.

The soluble fluoride used in the present invention is preferably sodium monofluorophosphate, sodium fluoride or tin fluoride.

The hydroxyapatite used in the present invention is selected in various manners, and among them, those having an average particle diameter of 1 to 50 μm, more preferably 3 to 30 μm are particularly preferable. If the average particle size is less than 1 μm, the workability is poor, and if it exceeds 50 μm, the usability is impaired. Further, it is desirable to add hydroxyapatite in an amount of usually 1 to 50%, more preferably 3 to 10%, and if it is less than 1%, the effect of hydroxyapatite is not observed, and
If it exceeds 0%, it is difficult to obtain good properties. Furthermore, the specific surface area of the hydroxyapatite used in the present invention is preferably 100 m ² / g or less and a specific surface area of 100 m ²
If it exceeds / g, the reactivity of hydroxyapatite becomes too high, which adversely affects the stabilization of the properties and appearance.

The dentifrice composition of the present invention can be made into any of dosage forms such as toothpaste, liquid dentifrice, and tablets according to a conventional method, and is used in an appropriate component as necessary, for example, a usual oral composition. Dibasic calcium phosphate as an abrasive
Monobasic calcium phosphate, tribasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic acid anhydride, silica gel, aluminum silicate, insoluble sodium metaphosphate, magnesium triphosphate, magnesium carbonate, calcium sulfate, polymethacrylic acid Methyl, bentonite, zirconium silicate, synthetic resin or the like is used, as a wetting agent, sorbit, propylene glycol, concentrated glycerin, polyethylene glycol or the like is used, and as a thickener, sodium carboxymethyl cellulose, carrageenan, xanthan gum, sodium alginate, Hydroxyethyl cellulose and the like are used, and as the surfactant, sodium lauryl sulfate, sodium lauroyl sarcosine, sucrose fatty acid ester, lauri Acid diethanolamide, polyoxyethylene hardened castor oil, polyoxyethylene-polyoxypropylene block copolymer or the like is used,
Other preservatives such as sodium benzoate and methylparaben, essential oils such as peppermint and spearmint, and fragrances such as l-menthol, carvone and anethole.
Sodium saccharin, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, thaumatin,
Perillartine, P-methoxycinnamic aldehyde,
Sweeteners such as xylitol, and cetylpyridinium chloride, chlorhexidine hydrochloride, triclosan, dextranase, mutanase, hinokitiol, lysozyme, allantoin, dipotassium glycyrrhizinate, epsilon aminocaproic acid, tranexamic acid, sodium chloride,
Active ingredients such as azulene and isopropylmethylphenol can be added within a range that does not impair the effects of the present invention.

[0011]

EXAMPLES The present invention will be described in more detail below with reference to examples and experimental examples. Examples 1 to 15 and Comparative Example 1 Experiment A toothpaste toothpaste shown in Table 1 was produced according to a standard method, and after leaving each toothpaste at 55 ° C. for 3 months, the properties and feeling of use were evaluated according to the following evaluation criteria. (Evaluation criteria) ○: Good Δ: Some problem ×: There is a problem (Comprehensive evaluation) ◎: Both property and feeling of use are ○: There is △ in either property or feeling of use ×: Either of property or feeling of use Is x

[Table 1] As is clear from the results shown in Table 1, it is found that the properties and appearance are stable by containing one or more selected from polyethylene glycol having a specific degree of polymerization and vitamin E derivative.

[0012]

[0013]

[0014]

[0015]

EFFECTS OF THE INVENTION According to the present invention, a dentifrice composition which is effective in preventing dental caries and which has stable properties over time can be obtained.

Claims (12)

[Claims] 1. A dentifrice composition containing hydroxyapatite and a soluble fluoride, wherein the dentifrice contains one or more selected from polyethylene glycol and a vitamin E derivative as a stabilizer. 2. The dentifrice composition according to claim 1, wherein the weight ratio of polyethylene glycol and hydroxyapatite is 1: 0.5 to 1:50. 3. The dentifrice composition according to claim 1, wherein the vitamin E derivative and the hydroxyapatite are in a weight ratio of 1: 1 to 1: 1000. 4. The dentifrice composition according to claim 1, wherein the soluble fluoride is one or more of sodium monofluorophosphate, sodium fluoride and tin fluoride. 5. Polyethylene glycol has an average degree of polymerization of 3
The dentifrice composition according to claim 1, wherein the dentifrice composition is from 00 to 600. 6. The dentifrice composition according to claim 1, wherein the vitamin E derivative is one or more selected from tocopherol nicotinate and tocopherol acetate. 7. The dentifrice composition according to claim 1, wherein the vitamin E derivative is tocopherol nicotinate. 8. The blending amount of polyethylene glycol is 1 to
20% dentifrice composition according to claim 1. 9. The dentifrice composition according to claim 1, wherein the blending amount of tocopherol nicotinate and tocopherol acetate is 0.01 to 1%. 10. The dentifrice composition according to claim 1, wherein the hydroxyapatite has an average particle size of 1 to 50 μm. 11. The compounding amount of hydroxyapatite is 1.
The dentifrice composition according to claim 1, which is about 50% by weight. 12. The dentifrice composition according to claim 1, wherein the specific surface area of hydroxyapatite is 100 m ² / g or less.