JPH08175954A - Skin cosmetic - Google Patents

Abstract

PURPOSE: To provide a skin cosmetic containing a plant selected from among Euphorbia lathyris, leaf mustard and madder or its extract as an active component and having excellent effect to suppress the wrinkling and pigmentation of the skin. CONSTITUTION: This skin cosmetic contains one or more substances selected from among Euphorbia lathyris, leaf mustard and madder and its extract as active components in an amount of usually 0.001-20wt.% in terms of dried solid. It is further compounded with an anti-inflammation agent and an antioxidant and optionally conventional cosmetic components and prepared in the form of O/W-type or W/O-type emulsified cosmetic, cream, cosmetic milky lotion, face lotion, oily cosmetic, pack, foundation, etc. The above plant is dried and pulverized whole grass, leaf, stalk, root, fruit, seed or flower and the extract is a liquid extract obtained by pulverizing the dried or undried plant and extracting with a solvent, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic, and more particularly to a skin cosmetic excellent in the action of suppressing skin wrinkle formation and pigmentation.

[0002]

2. Description of the Related Art In recent years,
Maintaining healthy and beautiful skin has become a serious concern for people of all ages. However, the skin is subtly affected by temperature, humidity, ultraviolet rays, aging, illness, stress, eating habits, etc. Therefore, various troubles such as deterioration of various functions of the skin and aging of the skin occur. A typical example of skin aging is "wrinkles"
Or "stain (pigmentation)" is formed, which is a great cosmetic problem especially for women.

Of these, wrinkles, which are one of the problems in the dermis, are aging of the skin due to aging and sunlight (photoaging).
Caused by. Although the mechanism of aging is not clear, since the skin is located in the outermost layer of the body and plays the role of the front line of biological defense, accumulation of damage due to environmental factors greatly influences the skin aging phenomenon. It is believed that Among the environmental factors, UV light is considered to be the largest environmental factor involved in skin aging and wrinkle formation. It is known that free radicals (especially active oxygen) produced by UV irradiation on the skin not only induce acute inflammation such as sunburn, but also induce photoaging of the skin by repeated UV irradiation. ing. In addition, various free radicals and active oxygen (superoxide, hydroxy radical, singlet oxygen, etc.) produced by ultraviolet rays are damaged by DNA-protein crosslinks (crosslinks) in the dermal component, and protein crosslinks such as collagen and elastin. , Denaturation, inactivation of antioxidant enzymes such as SOD (superoxide dismutase), membrane lipid peroxidation of cell components and consequent deterioration of cell function, etc., and it is thought that wrinkles are formed as a result. (Fragrance Journal, Volume 11, p49-5
4, 1992).

Therefore, in order to prevent / treat the formation of wrinkles, use of antioxidants such as vitamin E (JP-A-61-215309, JP-A-62-263110) and various plant extractions have hitherto been carried out. Utilization of materials (Japanese Patent Laid-Open No. 62-61924)
JP-A-63-174911, JP-A-6-6504
No. 3, etc.), the use of extracellular matrix control agents such as collagen (JP-A-4-74016, JP-A-3-20206).
Japanese patent publication), the use of retinoic acid and α-hydroxy acid has been proposed.

On the other hand, pigmentation such as spots is caused by an increase in the melanin pigment synthesized in the epidermis by melanocytes, and the mechanism of its development includes ultraviolet rays, female hormones and genetic factors. Participation has been pointed out, but it is not yet fully understood. Therefore, drugs for the purpose of suppressing the production of melanin and reducing already-formed melanin have been studied as whitening agents, and arbutin, kojic acid, vitamin C, licorice extract (Japanese Patent Laid-Open No. 63-23809, Special Features). Kaihei 1-149
706), Cuckon (JP-A-64-16709), and hydroxystilbene (JP-A-64-3800).
9), 3-hydroxychromone (JP-A-55-1)
11410, JP-A-55-143908), isoflavones (JP-A-58-225004) and the like have been proposed. However, at present, there are almost no substances that are excellent in actual compoundability and have a high pigmentation-inhibiting effect, and conventional wrinkle-preventing and improving agents and whitening agents are not sufficiently effective.

[0006] Therefore, an object of the present invention is to provide a skin cosmetic which is effective in preventing skin aging, particularly preventing and improving wrinkles and pigmentation.

[0007]

Under such circumstances, the present inventor has conducted diligent studies, and as a result, the plant and its extract selected from Horthosoma chinensis, Mustard spinach and Akane have excellent anti-wrinkle formation action and pigmentation. The inventors have found that it has an inhibitory action and completed the present invention.

That is, the present invention relates to a plant selected from Horthosoma chinensis, Mustard spinach and Akane, or an extract thereof.
The present invention provides a skin cosmetic, which comprises one or two or more species as an active ingredient.

The plant used in the present invention means the whole grass or one or more parts (hereinafter referred to as "protocol") of its leaves, stems, roots, fruits, seeds and flowers, or this. It is dried and crushed, and the plant extract means that the raw material is dried or crushed without drying, and then extracted with a solvent at room temperature or under heating, or using an extraction device such as a Soxhlet extractor. It means various solvent extracts obtained by the extraction, a diluted solution thereof, a concentrated solution thereof, or a dried powder thereof. It is preferable to use seeds for Holtose, seeds for mustard spinach, and dried roots or extracts thereof for madder to be used in the present invention.

Examples of the solvent used for extraction include water, organic solvents and mixtures thereof, with organic solvents being particularly preferred. Preferred specific examples of the organic solvent include hydrocarbons such as petroleum ether, cyclohexane, toluene and benzene; halogenated hydrocarbons such as dichloromethane, chloroform and carbon tetrachloride; esters such as ether and ethyl acetate; ketones such as acetone. Alcohols such as butanol, propanol, ethanol, polyethylene glycol, propylene glycol, butylene glycol; pyridine and the like.

When, for example, aqueous alcohol is used as the organic solvent, a plant extract can be obtained by subjecting the plant to extraction treatment at 3 to 70 ° C. The obtained plant extract is
The extract may be used as it is as an active ingredient of the skin cosmetic composition of the present invention, or the extract may be diluted, concentrated, or freeze-dried, and then prepared into a powder or paste, which may be appropriately formulated before use. If necessary, it may be used after purification treatment such as deodorization and decolorization by a known method.

The blending amount of the above-mentioned active ingredient in the skin cosmetic of the present invention is not particularly limited, but usually it is preferably 0.001 to 20% by weight as a dry solid content, and more preferably 0.001. ~ 3% by weight.

The skin cosmetic of the present invention comprises, in addition to the above essential components,
Known anti-inflammatory agents such as allantoin and glycyrrhizin, α
-The addition of an antioxidant such as tocopherol or ascorbic acid can improve the effect of suppressing the formation of wrinkles and spots. Further, oils generally used as cosmetic ingredients, moisturizers such as hyaluronic acid and ceramide, ultraviolet absorbers, alcohols, chelating agents, pH adjusters, preservatives, thickeners, pigments, fragrances and the like can be optionally used. It can be combined and compounded.

The skin cosmetics of the present invention are not limited to general skin cosmetics but include quasi drugs, cosmeceuticals and the like. The skin cosmetic of the present invention can be used in various forms and applications, for example, oil / water type, water / oil type emulsified cosmetics, creams, lotions, lotions, oily cosmetics, packs, foundations and the like. .

[0015]

The skin cosmetic of the present invention has an excellent effect of suppressing the formation of wrinkles and pigmentation (spots) caused by irradiation with ultraviolet rays, and is therefore useful as a cosmetic for preventing wrinkles and pigmentation.

[0016]

The present invention will be described below with reference to examples, but the present invention is not limited to these examples.

Production Example 1 Production method of Spinach extract: 1 kg of ground millet seeds was immersed in 5 liters of 70% ethanol at room temperature for 1 week to extract a 70% ethanol-soluble component. The same operation was repeated for the residue obtained by separating the extract, and a total of 10 liters of extract was obtained. The solvent of this extract was distilled off, and the residue was dried under reduced pressure to give 30 g of an extract.

Production Example 2 Production method of mustard spinach extract: 1 kg of ground mustard seed crushed product in Production Example 1
57 g of an extract was obtained in the same manner as in Production Example 1 except that was used.

Production Example 3 Production Method of Akane Extract: 38 g of an extract was obtained in the same manner as in Production Example 1 except that 1 kg of the crushed root of Akane was used in Production Example 1.

Test Example 1 Wrinkle formation inhibition test by hairless mouse: 80 μl of a 2% ethanol solution of the plant extract obtained above was applied to the back of a hairless mouse (HR / ICR, 6 weeks old at the start of the experiment). After 2 hours, extract the plant extract on the skin surface with ethanol, prepare 6 health ray lamps (Toshiba, SE20), and irradiate once
The UV-B light was radiated with the MED being adjusted to be not more than MED, and the irradiation was performed 5 times a week for 10 weeks. The amount of irradiation energy is UV-Radiometer (TOKY
O OPTICAL, UVR-305 / 365D)
It measured using. As a control, a sample coated with only ethanol was tested in the same manner as the sample. After the test was completed, the frequency of the wrinkles formed was evaluated with the naked eye below according to the following criteria (wrinkle index). The results are shown in Table 1.

Wrinkle index 0: No wrinkle formation. 1: Wrinkles are slightly formed. 2: Trace formation of wrinkles. 3: Some wrinkles formed. 4: Wrinkles are strongly formed.

Test Example 2 Analysis of Wrinkles: In order to analyze the wrinkles formed in Test Example 1 in detail, each mouse was treated with Hydrophilic Exaflex hydrophilic vinyl silicone impression agent at three locations in a circle with a diameter of 1 cm. A skin replica was collected from. This replica was irradiated with light from the direction of 30 degrees in a horizontal state, and the proportion of shadows formed by wrinkles was obtained as an area ratio using an image analyzer. The results are shown in Table 1.

[0023]

[Table 1]

Test Example 3 UV-on the back of a brown guinea pig
Effect of B on pigmentation: After brown hair of a guinea pig was shaved carefully with a hair clipper and a shaver, 1.
It was divided into eight 5 cm squares. Evaluation sample (2%
An ethanol solution (20 μl) was applied, and after 2 hours, the applied sample was wiped with ethanol and irradiated with ultraviolet rays in the UV-B region at twice the minimum erythema dose (MED). After UV irradiation, the evaluation sample was applied again. The above operation was repeated for 3 days. After that, samples (2% ethanol solution, 10
μl) was applied continuously for 1 week, and after 2 weeks, the amount of pigmentation was examined. As a control, a sample coated with only ethanol was tested in the same manner as the sample.

A color difference meter (CMS-12, manufactured by Murakami Color Co., Ltd.) was used for evaluation.
00) was used for measurement, and L was calculated from the obtained Munsell value.
^{* The} value was calculated, ΔL ^* was calculated according to the following formula, and the degree of pigmentation was compared. The larger the value of −ΔL ^*, the stronger the degree of pigmentation. Table 2 shows the results.

[0026]

[Formula 1] ΔL ^* = (L ^* value 2 weeks after UV-B irradiation) −
(L ^* value before UV-B irradiation)

[0027]

[Table 2]

From Table 2, it can be seen that the plant extract according to the present invention has an excellent pigmentation-inhibiting action.

The cosmetics shown in Examples 1 to 3 were prepared by a conventional method.

Example 1 Cream:

Table 3 (Components) (wt%) Akane extract 1 Cholesterol 0.5 Cholesterol isostearate 1 Polyether-modified silicone 1.5 Cyclic silicone 20 Methylphenylpolysiloxane 2 Methylpolysiloxane 2 Magnesium sulfate 0.5 55% Ethanol 5 Carboxymethyl chitin 0.5 Perfume, dye Micro purified water Fuel gauge 100.0

Example 2 Skin lotion:

[Table 4] (Components) (% by weight) Mustard spinach extract 2 Glycerin monostearate 1 Ethanol 15 Propylene glycol 4 Isopropyl palmitate 3 Lanolin 1 Methyl paraoxybenzoate 0.1 Perfume, pigment Micro- purified water Residual amount meter 100. 0

Example 3 Packing agent:

[Table 5] (Components) (wt%) Akane extract 3 Polyvinyl alcohol 20 Glycerin 5 Ethanol 16 Perfume, pigment Micro- purified water Residual amount meter 100

Front page continuation (72) Inventor Ichiro Tokimitsu 89-28 Takebayashi-cho, Utsunomiya City, Tochigi Prefecture

Claims (1)

[Claims] 1. A skin cosmetic comprising, as an active ingredient, one or two or more kinds of plants selected from spinach, mustard spinach and madder or their extracts.