JPH0798B2 - Foreign matter removing device in ampoule - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION <Industrial field of application> The present invention sequentially supplies a large number of ampoules to a foreign substance testing machine used for selecting defective ampoules, and
The present invention relates to a foreign matter removing device in an ampoule for removing foreign matter attached to an inner peripheral surface of a branch portion of the ampoule.

<Summary of the Invention> The present invention provides a mechanism for continuously supplying a large number of ampoules filled with a chemical solution and sealed in a foreign substance tester,
A transfer means for sequentially transferring the ampoules in parallel,
Along the transfer path of the ampoule, a first upright guide part for guiding each ampoule upright, a fall guide part for falling over in a horizontal state, and a second upright guide for standing upright again in an upright state.
And a vibration adding means for applying vibration to the ampoule along the tipping guide part, whereby foreign matter adhering to the inner peripheral surface of the branch of the ampoule is peeled off by the foreign matter tester. The foreign matter is detected so that the defective ampoule can be reliably selected.

<Prior Art> Conventionally, there is known an ampoule in which a drug solution such as an injection solution is filled. Since the drug solution filled in this ampoule is injected into the human body via an injection needle, etc., strict quality control is required, and if foreign substances are mixed in the drug solution, it will be rejected as a defective ampoule. There must be.

By the way, one of the causes of such foreign matter being mixed into the ampoule is scorching that occurs on the inner peripheral surface of the branch part of the ampoule during the ampoule filling and sealing process.

That is, in the case of manufacturing an ampoule, as shown in FIG. 12, the head portion of the branch portion (101) formed in a thin diameter is provided on the upper part of the drug solution storage portion (100) formed in a large diameter. The injection needle (103) is inserted through the opened opening (102), and the drug solution (104) is injected into the storage section (100) from the outside through the injection needle (103).

After the injection needle (103) is pulled out, the opening (102) is heated and melted and closed. The ampoule is manufactured by such a process, but since the injection of the drug solution (104) by the injection needle (103) is performed under a constant pressure, the drug solution (104) is injected during the injection of the drug solution (104). )
Adhere to the inner peripheral surface of the branch part (101), or when the injection needle (103) is pulled out from the opening part (102), the injection needle (103) and the branch part (101) come into contact with each other. Then, as shown in FIG. 13, it may adhere to the inner peripheral surface of the branch portion (101).

Thus, if the opening (102) is melt-sealed with the chemical liquid (104) attached to the inner peripheral surface of the branch portion (101), the opening (102) may be changed depending on the type of the chemical liquid (104). The high temperature applied to the branch part (101) of the ampoule at the time of ()) heats the chemical liquid (104) attached to the inner peripheral surface of the branch part (101) and carbonizes it, which may result in a dark brown charred char. is there.
In particular, in the case of an injection solution containing glucose, vitamins and the like, the above-mentioned scorching easily occurs.

Therefore, the above-mentioned ampoule with burnt charcoal is
Skilled workers visually selected and rejected as defective ampoules.

However, it is not always possible to select completely depending on the size of the scorched charcoal, the shade, and the position of adhesion, which is a problem in quality assurance.

Therefore, conventionally, a highly automated foreign substance tester has been proposed for selecting an ampoule in which a foreign substance such as the above-mentioned scorched charcoal is mixed in the chemical liquid. According to this foreign substance tester, when a foreign substance such as a scorched charcoal is mixed in the chemical liquid, an ampoule containing the foreign substance can be detected with a high probability and eliminated as a defective ampoule.

<Problems to be Solved by the Invention> However, the foreign substance tester functions effectively when foreign substances are mixed in the chemical liquid filled in the ampoule, and can select a defective ampoule. However, it is impossible to detect the foreign matter when the foreign matter is not mixed in the chemical solution and adheres to the inner peripheral surface of the branch portion of the ampoule, and cannot be excluded as a defective ampoule.

Therefore, the present invention has been proposed in order to solve the problems of the conventional techniques as described above, and in a mechanism for successively supplying ampoules to a foreign substance tester successively, a branch portion of the ampoule is provided. The purpose of the present invention is to remove foreign matter adhering to the inner peripheral surface of the product and mix it into the chemical solution so that the foreign substance detection function of the foreign substance testing machine can be effectively exerted and that defective ampoules can be reliably selected. To do.

<Means for Solving the Problems> In order to achieve the above object, the present invention provides a mechanism for continuously supplying a large number of ampules filled with a chemical solution and sealed in a foreign substance tester in parallel with each other. A first upright guide part for guiding each ampoule to an upright state along the transfer path of the ampoule, and each of the ampoule tumbling down horizontally to the upright guide part. A tipping guide part for guiding, and a second erecting guide part for guiding each ampoule upright again in an upright state continuously to the tipping guide part and guiding the ampoule toward the foreign substance tester.
Further, a vibration applying means for applying vibration to the ampoule is arranged along the tipping guide portion.

<Operation> The present invention provides the first guide portion, the tipping guide portion, and the second upright portion along the transfer path of the ampoule formed by the transfer means for continuously supplying a large number of ampules to the foreign substance tester. Since the guide portions are respectively configured, the ampoule is first made upright with respect to the transfer path by the first upright guide portion before being supplied to the foreign substance tester. Then, after being made horizontal by the fall guide portion, it is again guided and erected by the second upright guide portion so as to be made upright again. As the ampoule is gradually made horizontal by the tipping guide part, the chemical liquid filled in the ampoule is gradually formed above the storage part from the chemical liquid storage part having a large diameter. The chemical solution flows into the branch portion, and when it is horizontal, the chemical solution also flows into the head portion of the branch portion.

Since the present invention has a vibration adding means for adding vibration to the ampoule along the tipping guide part as a constituent element, the vibration adding means is brought into the horizontal state as described above and the liquid medicine flows into the branch part. Vibration is applied to the ampoule in this state, and the vibration causes the chemical solution in the ampoule and the inner peripheral surface of the branch portion to come into contact with each other, whereby foreign substances adhering to the branch portion are separated and mixed into the chemical solution.

Furthermore, since the ampoule is again erected in the upright state by the second upright guide portion, the foreign matter separated by the vibration applying means and mixed in the chemical liquid flows into the chemical liquid storage portion from the branch portion together with the chemical liquid. Therefore, the ampoules in which the foreign matter is mixed in the chemical liquid are sequentially transferred and supplied to the foreign matter tester.

<Example> Hereinafter, an example of the present invention will be described with reference to the drawings.

The foreign matter removing device (1) according to the present embodiment is, as shown in FIG. 1, schematically formed in the longitudinal direction of a base (2) and rotationally driven to form a large number of ampoules (3). A screw (4) to be transferred, and a guide rod (5) for guiding each ampoule (3) along a transfer path of the ampoule (3) formed by rotational driving of the screw (4),
(6) and vibration adding means (7) provided in parallel with the screw (4) and adding vibration to the ampoule (3).
Etc.

In the case of this embodiment, the screw (4) is supported by bearings (8) and (9) on both sides, and as shown in FIG.
The peripheral surface has a spiral mountain portion (11) that forms a valley portion (10) at a space where at least each ampoule (3) can be fitted. An outer bearing (13) is provided at one end of the screw (4) so as to face the bearing (8) that supports the rotating shaft (12) of the screw (4). Supports (12). A drive belt (14) connected to a drive motor (not shown) provided in the base (2) is stretched around the rotary shaft (12). The screw (4) is rotated by being transmitted to the rotary shaft (12) of the screw (4) via the drive belt (14) by the rotational driving force of the drive motor.

Further, a rectangular feed tray (15) accommodating a large number of ampoules (3) is provided on one side of one end side of the screw (4), and the bottom surface of the feed tray (15) is a third tray. As shown in the figure, a belt conveyor (16) is provided, and the rotation of the belt conveyor (16) causes the plurality of ampules (3) stored upright in the supply tray (15) to , Sequentially transferred in the direction of the screw (4) (direction of arrow F in FIG. 3) and fitted into the valley (10) between the peaks (11) formed on the peripheral surface of the screw (4). Then, the screw (4) is sequentially driven in the direction of the foreign substance tester (60), which will be described later, by rotationally driving the screw (4).

Further, as shown in FIG. 4, a curved plate (17) made of a metal material is disposed on one side of the supply tray (15). The curved plate (17) has, for example, two continuous arcuate portions (18) and (19), one end (20) of which is attached to the side wall (21) of the supply tray (15), and The other end (20a) is a free end for elastically urging a large number of ampules (3) in the direction of the side wall (22) provided opposite to the side wall (21) to which the curved plate (16) is attached. Has been made. Due to the curved plate (17), a large number of ampoules (3) housed in the supply tray (15) gradually move in the direction of the side wall (22) (direction of arrow Y in the figure), and thus in the transfer direction. It prevents the ampoule (3) that is housed from accumulating. An auxiliary member (24) having a curved surface (23) is provided on the front side of the side wall (21) provided with the curved plate (17), and the curved plate (17) has a large number of ampules (3). ), The curved plate (17) comes into contact with the curved plate (17) when it is pressed in a direction opposite to the elastically urging direction.

Furthermore, in this embodiment, a shutter plate (25) is provided between the supply tray (15) and the screw (4) so as to be reciprocally movable in the longitudinal direction of the screw (4). The shutter plate (25) is provided with an elliptical cam surface (26) formed by cutting a cylindrical body in an inclined direction, and a rotary member (28) rotatably arranged by a rotary shaft (27).
And a cam projection (29) which is in sliding contact with the cam surface (26) of the rotating member (28) and is slidable in the axial direction of the guide shaft (30) by the guide shaft (30). The sliding block (31), a shutter plate (25), and a protrusion (32) connecting the sliding block (31) across the rotating member (28). The rotating member (28) is attached to a rotating shaft (27) provided on the base end side of the rotating member (28) by rotational driving of a drive motor arranged in the base (2) (not shown). The guide shaft (3) is adapted to rotate via a stretched drive belt (33) and guides the sliding of the sliding block (31).
0) is the outer surface (2) of the side wall (22) of the supply tray (15).
It is projected from 2) and this sliding block (3
1) The side wall (22) and a tension spring (34) urged to constantly pull the sliding block (31) in the direction of the side wall (22) are arranged on the upper side surface part (31a). There is. Therefore, the sliding block (31) has the rotating member (28).
By the rotational driving of the rotary member (28), it slides in the axial direction of the guide shaft (30) through the cam projection (29) which is in sliding contact with the cam surface (26) of the rotary member (28), and the sliding block (31).
The shutter plate (25) connected to the shutter plate (32) via the projecting piece (32) slides in the axial direction of the screw (4). With this shutter plate (25), each ampoule (3) sequentially transferred in the direction of the screw (4) by the belt conveyor (16) is temporarily stopped and formed between the ridges (11) of the screw (4). The above-mentioned screw (4) so that it can be easily fitted into the cut valley (10).
It prevents the ampoule from being fed in blank.

In the present embodiment, the transfer means, which is a constituent element of the present invention, is constituted by the screw (4) having the spiral mountain portion (11) formed as described above. The individual ampoule (3) is not limited to such a configuration.
Other elements may be used as long as they can be sequentially transferred in parallel.

As shown in FIG. 1, the present device (1) has two guide rods (5), (6) and an auxiliary guide rod (35) extending from one end to the other end of the screw (4). , (36) are provided and respectively constitute a first upright guide portion (X), a fall guide portion (Y), and a second upright guide portion (Z). In this embodiment, each of the guide portions (X), (Y), (Z) according to the present invention is connected to the guide rods (5), (6).
This device (1) can be easily manufactured by mainly configuring the device.

The guide rods (5), (6) and the auxiliary guide rod (35)
Has a circular cross section, and one end thereof has an outer surface (21) of the side wall (21) of the supply tray (15) as shown in FIG.
Installed in a). The guide rod (5) guides the upper portion of the drug solution storage portion (3a) of the large number of ampoules (3) transferred by the screw (4), and the guide rod (6) guides the drug solution storage portion (3a). ), And the auxiliary guide rod (35) guides the middle part of the chemical liquid storage section (3a).

As described above, in the present embodiment, each of the first upright guide portion (X), the fall guide portion (Y), and the second upright guide portion (Z), which are the constituent elements of the present invention, has a circular cross section. Since the guide rods (5), (6) and (35) are used, the frictional force generated between the guide rods (5), (6) and (35) can be minimized.

And these guide rods (5), (6), (35)
As shown in FIG. 5 and FIG. 6 (a), an L-shaped support member (3) attached to the side wall (21) at an intermediate portion.
It is supported by 7). This support member (37) includes
Stoppers (38), (39), (40) having a semicircular cross-section are provided, and the guide rods (5), (6), are provided by these stoppers (38), (39), (40). Holds (35).

The guide rods (5), (6), and (35) are connected to the support member (37) from the side wall (21) of the supply tray (15).
Up to the first upright guide portion (X), each ampoule (3) transferred to the screw (4) from the support member (37) toward the transfer direction of the ampoule (3) is A tipping guide portion (Y) that guides the user to fall gradually is configured.

That is, the guide members (5), which are arranged on one side of the screw (4) at predetermined intervals, respectively.
Each of (6) and (35) is bent little by little and gradually positioned above the screw (4).

Therefore, the above guide members (5), (6), (35)
The large number of ampoules (3) transported while being guided by is gradually inverted so as to be horizontal as shown in FIGS. 6 (a) to 6 (d). And
As the liquid is stored in the ampoule (3), the liquid medicine stored in the ampoule (3) gradually falls.
From (a), it gradually flows into the branch portion (3b) provided at the upper end of the chemical liquid storage portion (3a).

The auxiliary guide rod (35) arranged between the guide rods (5) and (6) has the support member (37) at the middle portion.
Is supported by and the end portion is an intermediate support member (41).
And guides until the ampoule (3) becomes horizontal, and thereafter the horizontal support member (2a),
The guide rods (5), (6) supported by (2b)
However, as shown in FIG. 7, the ampoule (3) is guided so as to maintain the horizontal state.

The plurality of ampules (3) are guided by the guide rods (5) and (6) so as to maintain a horizontal state, and gradually driven by the rotation of the screw (4) toward the discharge tray (42). While being transferred to, the vibration is added by the vibration adding means (7) provided on the side of the screw (4). The vibration adding means (7) is the seventh
As shown in FIG. 6 and FIG. 6D, a long horizontal base (43), substrate support members (44) and (45) for supporting both ends of the horizontal substrate (43), The horizontal substrate (4) is extended from the vibrator (46) provided in the base (2).
The contact member (46a) is in contact with the lower surface of (3). The horizontal substrate (43) is an elongated flat plate (47).
And a standing plate (48) formed upright on one side of the flat plate (47)
And a synthetic resin protective sheet (49) attached to the upper surface of the flat plate (47), and a large number of ampoules guided horizontally by the guide rods (5) and (6). The branch portion (3b) of (3) abuts on the upper surface of the protective sheet (49). Above protective sheet (4
9) prevents the ampoule (3) from cracking due to vibration applied by the vibrator (46) described below, and the standing plate (48) is placed on the protective sheet (49). This prevents the ampoule (3) abutting against the screw (4) from coming off laterally due to the vibration given by the vibrator (46). At both ends of the horizontal substrate (43) configured as described above, a substrate support member (4) for supporting the horizontal substrate (43) is provided.
4) and (45) are provided, and this substrate support member (4
4) and (45) are crank-shaped, and the base end is attached to the base (2), and the front end is a stopper plate (50), (5).
It is fixed to the horizontal substrate (43) by 1) and supports the horizontal substrate (43). The substrate support member (4
4) and (45) are cushioning materials (52) and (53) formed of rubber plates at two positions, that is, a position facing the horizontal substrate (43) and a mounting position of the base (2). ,(Five
4) and (55) are provided, and the cushioning materials (52) and (5)
The vibrations given by the vibrator (46) are prevented from spreading to the entire device (1) by 3), (54) and (55). The vibrator (46) is arranged in the base (2) and applies vibration to the horizontal substrate (43) via the contact member (46a).

Further, in this embodiment, as described above, the transfer means which is a component of the present device (1) is provided with the spiral ridges (11) on the peripheral surface, and the valleys formed between the ridges (11). Since each ampoule (3) is fitted in and transferred to the inside of the screw (4), a large number of ampoules (3) placed horizontally are subjected to vibration by the vibrator (46). Along with the rotation of the screw (4), as shown in FIG. 8, the drug solution storage portion (3a) of the ampoule (3) comes into contact with the screw (4) to rotate around the axis of the ampoule (3). Can be rotated in the direction.

In this way, a large number of ampules (3) are made horizontal by the guide rods (5) and (6) and are attached to the upper surface of the horizontal substrate (43) which constitutes the vibration applying means (7). In the branch portion (3b) of the ampoule (3), since it comes into contact with the attached protective sheet (49), vibration is applied by the vibrator (46), and it is further rotated around the axis of the ampoule (3). When foreign matter (G) is attached to the foreign matter (G), the chemical liquid that has flowed into the branch portion (3b) and the foreign matter (G)
The and will come into contact with each other and be evenly separated.

In addition, in the present embodiment, one vibrator (46) is used as the vibration applying means, but the present invention is not limited to the number of vibrators shown in the present embodiment, and the above vibrator is used. Instead, the present invention may be configured using, for example, an ultrasonic wave generator.

Then, the inventor of the present application uses the vibrator (46) as the vibration applying means and the ampule (3) in the two cases of using the ultrasonic generator.
The following experiment was conducted in order to measure the peeling of the foreign matter (G) adhering to the inner peripheral surface of the branch portion (3b).

(Experimental example 1) In this experimental example, the results of performing the vibration (46) on each ampoule (3) guided in the horizontal state by changing the conditions of the frequency, the vibration force, and the vibration time respectively. As the peeling rate of the foreign matter (G) attached to the inner peripheral surface of the branch portion (3b), the numerical values shown in Table 1 below could be obtained.

(Experimental example 2) In this experimental example, by the ultrasonic generator which is not shown,
As a result of applying vibration to the ampoule (3) by changing the frequency and the output with the irradiation time being 10 seconds, the numerical values shown in Table 2 below could be obtained as the peeling rate of the foreign matter (G).

Next, as described above, the ampoule (3) which is guided to fall in a horizontal state by the guide rods (5) and (6) forming the tipping guide portion (Y) and which is vibrated by the vibration adding means (7) is The guide rods (5), (6) and the auxiliary guide rod (36) forming the tipping guide portion (Y) are again erected to stand upright. That is, as shown in FIG. 9, the guide rods (5) and (6) located substantially above the screw (4) to make the ampoule (3) horizontal are formed in a U shape. Support members (56) connected in series,
The auxiliary guide rod (36) is mounted on the side wall (48) of the discharge tray (42) and is supported by (57) and is bent slightly toward the side of the screw (4). ) Has one end attached to a horizontal rod support member (2b) that supports the guide rods (5) and (6) and is located between the guide rods (5) and (6), and the ampoule (3) The end portion is arranged so as to guide the middle part of the chemical solution storage portion (3a) and is attached to the side wall (58) of the discharge tray (42) like the guide rods (5) and (6).
The ampoules (3) that are in a horizontal state by the guide rods (5), (6), (36) are shown in FIGS. 9 and 10 (a) to 10 (c). As shown in the drawing, the drug solution that is guided to gradually stand up and is housed in the branch portion (3b) of the ampoule (3) gradually flows into the drug solution container (3b) again gradually. Then, the foreign matter (G) separated by the vibration adding means (7) flows into the chemical liquid storage section (3a) together with the chemical liquid.

As described above, each ampoule (3) guided in the upright state by the guide rods (5), (6), (36) forming the second upright guide portion (Z) is moved by the screw (4). The particles are sequentially transferred to the discharge tray (42) and are supplied from the foreign matter removing device (1) to the foreign matter tester (60) arranged in series with the discharge tray (42) through a supply belt (61). .

As shown in FIG. 11, the foreign substance tester (60) includes a supply star wheel (62), an SD head (63), and a projector (6).
4), (65), an excluding star wheel (66), an excluding screw (67), and a pendulum (68).

The supply star wheel (62) is formed in a disk shape and is rotatable by a shaft (69), and is provided with a number of recesses (70) for holding the chemical liquid storage section (3a) of the ampoule (3) on its peripheral surface. Has been done. An SD head (63) is provided on one side of the supply star wheel (62).
The SD head (63) has a disc-shaped upper plate portion (71) provided with a holding member (71) for holding the upper end of the ampoule (3) held by the foil (62) from the supply star wheel (62). 72) and a lower plate part (74) provided with a holding member (73) for holding the lower end of the ampoule (3), and the upper plate part (72) and the lower plate part (74) are synchronized with each other. It is formed so as to rotate freely. Moreover, the above SD head (63)
Two light projectors (64), (65) for detecting the presence or absence of foreign matter (G) in the ampoule (3) by projecting light to each ampoule (3) held by the SD head (63) ) Is provided. The light projectors (64) and (65) project light into the chemical liquid storage portion of the ampoule (3), and when foreign matter (G) is mixed in the ampoule (3), a pendulum (described later) ( 68). Furthermore, on one side of the SD head (63),
An exclusion star wheel (66) is provided to take out the ampoule (3) held by the SD head (63), and to sort the ampoule (3) taken out from the exclusion star wheel (66) into a good product or a defective product. Excluding screw (67)
And the ampoule (3) which is operated based on the signals detected by the light projectors (64) and (65) and is taken out by the exclusion screw (67), is a non-defective product discharge port (75) or a defective product discharge port (76). ) And a pendulum (68) for allocating to each) are arranged.

Foreign matter (G) peeled by the foreign matter peeling device (1)
In the ampoule (3) in which the foreign matter (G) is mixed, the two light projectors (64) and (65) provided in the foreign matter tester (60) detect the mixed state of the foreign matter (G).
The pendulum (67) which operates with a signal from (65) discharges it to the defective product discharge port (76) and disposes of it as a defective ampoule (3).

As described above, according to the foreign matter removing device (1) of the present embodiment, the foreign matter (G) attached to the inner peripheral surface of the branch portion (3b) of the ampoule (3) is removed by the vibrator (46). The foreign matter detection function of the foreign matter tester (60) is effectively exerted because it can be supplied to the foreign matter tester (60) while being mixed in the chemical solution and mixed in the chemical solution. Thus, the defective ampoule (3) can be reliably selected.

<Effects of the Invention> According to the present invention, foreign matter adheres to the inner peripheral surface of the branch portion of the ampoule in the step of filling the ampoule with the chemical solution and then sealing the solution, so that the foreign matter tester cannot detect the foreign matter tester. Even if possible, the foreign matter is separated from the inner peripheral surface of the branch portion by the addition of vibration by the vibration adding means, which is a component of the present invention, and is supplied to the foreign matter tester in a state of being mixed in the chemical solution. be able to.

Therefore, the foreign substance detection function of the foreign substance tester can be effectively exerted, defective ampules can be reliably selected and eliminated, and a highly reliable ampule can be provided.

[Brief description of drawings]

FIG. 1 is a plan view of a foreign matter peeling apparatus according to an embodiment of the present invention, FIG. 2 is a perspective view showing a mechanism of a transfer means and a shutter plate, and FIG. 3 is a schematic side view showing an arrangement state of a belt conveyor. FIG. 4 is a plan view showing a disposition state of the curved plate, FIG. 5 is a side view showing a mounting state of the first upright guide portion, and FIGS. 6 (a) to 6 (d) are ampules. It is sectional drawing which shows a fall process, FIG.6 (a) is the sectional view on the AA line of FIG. 1, FIG.6 (b) is the sectional view on the BB line of FIG.1, and FIG.6 (c) is the first. 6 is a sectional view taken along line CC of FIG. 6, and FIG. 6 (d) is a sectional view taken along line DD of FIG. FIG. 7 is a perspective view showing a disposition state of the vibration adding means, FIG. 8 is a side view of an essential part showing a rotating state of the ampoule, and FIG.
FIG. 10 (a) is a perspective view showing the disposition state of the upright guide portion of FIG.
To FIG. 10 (c) are sectional views showing the standing state of the ampoule, FIG. 10 (a) is a sectional view taken along the line EE of FIG. 1, and FIG. 10 (b) is a sectional view taken along the line FF of FIG. Figure 10 (c) is G in Figure 1.
It is a -G line sectional view. FIG. 11 is a perspective view of the foreign substance tester. FIG. 12 is a cross-sectional view showing the step of filling the ampoule with the drug solution, and FIG. 13 is a cross-sectional view showing a state in which foreign matter is attached to the branch portion. (1) …… Foreign matter peeling device (3) …… Ampoule (3b) …… Branch (4) …… Screws (5), (6) …… Guide rod (7) …… Vibration adding means (60)… … Foreign matter testing machine

Claims (1)

[Claims] 1. A mechanism for continuously supplying a large number of ampoules filled with a chemical solution and sealed in a foreign substance tester, having a transfer means for sequentially transferring the ampoules in parallel, and a transfer path of the ampoule. Along the first upright guide part for guiding each ampoule upright, along with the upright guide part for overturning each ampoule in a horizontal state, and for each ampoule in succession. And a vibration adding means for adding vibration to the ampoule along the tipping guide part. A foreign matter removing device in an ampoule characterized by the above.