JPH07157427A - Dental surface anesthetic - Google Patents

Abstract

PURPOSE:To obtain such a dental surface anesthetic as to evidently realize the coated side, i.e., the site to which a local anesthetic is to be injected, when this anesthetic is applied onto the gingiva. CONSTITUTION:This anesthetic contains a total of >=0.01wt.% of an anesthetic active ingredient, a water-soluble polymeric base and a medium color- or a cold color-based colorant and has a viscosity at 40 deg.C of 300-1000cps.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dental surface anesthetic, more specifically, a dental surface whose application position can be clearly seen by a coloring agent that does not run off the gums or spread over a wide area when applied. It relates to anesthetics and is used in the field of dentistry.

[0002]

2. Description of the Related Art In the field of dentistry, when a local anesthetic is injected as a pretreatment for tooth extraction or the like, the gingiva at the injection site is subjected to surface anesthesia in advance. For this surface anesthesia, a colorless or yellow or slightly blue-colored gel preparation based on polyethylene glycol, which is a local anesthetic, ethylaminobenzoate as an active ingredient, is used. It is applied to the part.

[0003]

In order to bring out the effect of surface anesthesia, it takes about 5 minutes after applying the surface anesthetic, but during this time, the dentist may treat other patients. I'm busy. Conventional surface anesthetics are colorless, colored in the same system as gingiva (yellow), or very lightly colored even in blue. The site became unclear, and the dentist sometimes gave pain to the patient by injecting a local anesthetic into a site where the surface anesthetic was not applied, that is, a site where the surface anesthetic was not applied. Therefore, there is a demand for the development of a dental surface anesthetic agent in which it is easy to understand the site where the surface anesthesia is applied, that is, the site where the local anesthetic agent should be injected (point of insertion).

[0004]

Means for Solving the Problems The inventor of the present invention, when preparing a surface anesthetic, uses a water-soluble polymer base as a base to adjust the viscosity at 40 ° C. to 300 to 1000 centipoise, and further By blending 0.01% by weight or more of a systemic or cold colorant, when the surface anesthetic is applied to the gingiva, the surface anesthetic does not run off from the gingiva or spread over a wide range, and it is mixed. The present invention has been completed by finding that the applied portion becomes clear by the coloring agent. The dental surface anesthetic of the present invention contains 0.01% by weight or more of an active ingredient having a local anesthetic effect, a water-soluble polymer base and a neutral or cold colorant, and has a viscosity of 300 to 40 ° C. It is characterized by being 1000 centipoise.

Examples of the active ingredients used in the dental surface anesthetic of the present invention include ethyl aminobenzoate, parabutylaminoaminobenzoic acid diethylaminoethyl, lidocaine and the like, and usually 5 to 30% by weight in the preparation. To be done.

The water-soluble polymer base has a viscosity of 300 to 1000 centipoise at 40 ° C., because it is easy to apply the preparation to the gingiva and does not run off the gingiva or spread widely when applied. It is necessary to select a material having a pressure of preferably 400 to 700 centipoise. If the viscosity is less than 300 centipoise,
When applied to gingiva, it runs off the gingiva or spreads over a wide area. If the viscosity exceeds 1000 centipoise, the adhesiveness to the gingiva becomes poor.

An example of a preferred water-soluble polymer base for adjusting such a viscosity is polyethylene glycol which is liquid at room temperature (for example, polyethylene glycol 40).
0) and polyethylene glycol that is solid at room temperature (for example, polyethylene glycol 1500, polyethylene glycol 4000, polyethylene glycol 600).
0, a mixture of polyethylene glycol 20000), polyethylene glycol, polyvinylpyrrolidone,
Examples include polyvinyl alcohol, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, dextrin, gelatin, gum arabic and the like, which are melted and mixed with water. These water-soluble polymer bases are usually used in the formulation in the range of 60-9.
0% by weight is compounded.

[0008] As the coloring agent, it is necessary to add an intermediate-colored or cold-colored coloring agent in order to clearly distinguish it from the color of gingiva. As a preferable coloring agent, an intermediate-colored coloring agent such as a green pigment ( For example, Green No. 3, Green 201
No., Green No. 202, Green No. 204, Green No. 205, etc.), copper chlorophyll, sodium copper chlorophyll, titanium oxide, medicinal charcoal, and the like, and examples of cold colorants include blue dyes (for example, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204
No. 205, blue No. 205, etc.), purple No. 201, etc. Although these coloring agents vary depending on their types, 0.01% by weight or more, and preferably 0.05% by weight or more are blended in the preparation in order to clarify the application position. If the amount of the colorant is less than 0.01% by weight, the gingiva will be less colored and the application position will not be clear.

The dental surface anesthetic of the present invention contains saccharin sodium, saccharin,
It is preferable to add sweeteners such as sucrose, flavoring agents such as banana oil, cherry oil, orange oil and vanilla essence, and further preservatives such as methylparaben, ethylparaben, propylparaben, surfactants such as Tween80, purified water and the like. You may mix | blend suitably.

In the dental surface anesthetic of the present invention, a water-soluble polymer base is appropriately heated and melted, and an active ingredient having a local anesthetic action and a colorant appropriately dissolved in purified water are mixed and stirred therein. Furthermore, it can be prepared by mixing and stirring the above-mentioned sweeteners, flavors, preservatives and the like, if necessary. The dental surface anesthetic of the present invention thus obtained is used by applying it to the gingiva.

Test Example 1 Viscosity measurement sample Dental surface anesthetic agent of the present invention obtained in Example 1 described later Equipment used ・ E type viscometer type EM (VISCONIC EM)
D, TOKYO SEIKI) Setting conditions-Temperature 40 ° C (constant temperature water circulation system, use after stabilization for 2 hours or more) -Slit width: 5.6 Sample sampling and measurement method While taking it, I took it in a syringe. Then, the sample receiver was removed from the viscometer, and the sample was slowly transferred from the injection cylinder to the sample receiver so that the sample was uniform and no bubbles were mixed. The sample receiver was set on a viscometer and allowed to stabilize for 20 minutes or longer, after which it was measured at 5.0 RPM. The viscosity of the sample was 460 centipoise.

[0012]

The following experiment was conducted to examine the effect of the dental surface anesthetic of the present invention. Test Example 2 Ten adult volunteers were used as test subjects, and the sample application site was the mucosa of the anterior maxillary anterior part, gingiva-cheek transition part, assuming the puncture point when performing infiltration anesthesia. The preparation obtained in Example 1 below was applied to the mucosa by the following procedure. The upper lip was turned over with a dental mirror and applied to the mucous membrane part of the gingiva-cheek transition part using a cotton swab or dental tweezers. As a result, the dental surface anesthetic of the present invention had good adhesiveness to the gingiva, the formulation did not flow down or spread over a wide area, and the color (blue) of the coloring agent was clearly visible. Therefore, there is an advantage that the insertion point becomes clear when the local anesthetic is injected, and it is easy to use.

[0013]

【Example】

Example 1 Polyethylene glycol 4000 (64 kg) was placed in a vacuum kneader (manufactured by Mizuho Industry Co., Ltd.) and heated to 70 ° C. to melt it, and polyethylene glycol 400 (88 kg) was uniformly mixed and kept at 70 ° C. While maintaining at 70 ° C, ethyl aminobenzoate (40 kg) and methylparaben (0.
4 kg) is added and mixed to dissolve. Purified water (4.5k
Blue No. 1 (0.1 kg) and sodium saccharin (2 kg) were added to g) and dissolved by stirring at room temperature, and this solution was added to the above polyethylene glycol solution together with banana oil (1 kg) and uniformly mixed, and the mixture was allowed to reach room temperature. Upon cooling, 100 g of dental surface anesthetic having the following composition is obtained.

[Table 1]

Claims (4)

[Claims] 1. An active ingredient having a local anesthetic effect, a water-soluble polymer base, and a neutral or cold colorant are added in an amount of 0.
Contains at least 01% by weight and has a viscosity of 300 to 40 ° C.
A dental surface anesthetic, which is 1000 centipoise. 2. The dental surface anesthetic according to claim 1, wherein the active ingredient is ethyl aminobenzoate. 3. The dental surface anesthetic according to claim 2, wherein the colorant is a blue pigment. 4. The dental surface anesthetic according to claim 2, wherein the water-soluble polymer base is a mixture of liquid and solid polyethylene glycol at room temperature.