JPH06271442A - Skin external preparation - Google Patents

Abstract

PURPOSE:To obtain a skin external preparation excellent in effects on prevention of skin roughening, dermal stains or ephelides due to ultraviolet rays. CONSTITUTION:This skin external preparation comprises an ultraviolet absorber and/or an ultraviolet scattering agent and glabridin and/or glabrene.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation, and more particularly to a skin external preparation having an excellent effect of preventing skin roughness, spots and freckles caused by ultraviolet rays.

[0002]

2. Description of the Related Art Skin is exposed to ultraviolet rays to cause a sunburn phenomenon and the skin is blackened. These usually return to the original skin color after a lapse of days, but repeated irradiation with ultraviolet rays causes rough skin, stains and freckles, and when they worsen, skin cancer may develop. In recent years, such problems have been particularly noticed, and many cosmetics that protect the skin from ultraviolet rays have been marketed. These products contain substances that absorb ultraviolet rays and substances that scatter ultraviolet rays, and have been devised to block ultraviolet rays on the skin surface.

[0003]

However, it is difficult to completely block ultraviolet rays even when an external skin preparation containing an ultraviolet absorber or an ultraviolet scatterer is used.
When the external skin application on the skin surface becomes uneven due to sweating or physical contact, the UV blocking effect is reduced,
It causes rough skin, stains and freckles.

[0004]

SUMMARY OF THE INVENTION In view of the above circumstances, the inventors of the present invention have earnestly studied in order to obtain an external preparation for the skin, which has a high ultraviolet blocking effect and an excellent effect of preventing skin roughness, spots and freckles caused by ultraviolet rays. As a result of repeated piling, it was found that the above problems can be solved by using an ultraviolet absorber and / or an ultraviolet scatterer in combination with glabridine and / or glabrene, and the present invention has been completed. That is, the present invention is a topical skin preparation containing at least one of an ultraviolet absorber and / or an ultraviolet scatterer, and glabridine and / or glabrene.

The structure of the present invention will be described in detail below. As the ultraviolet absorber used in the present invention, para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl PABA Benzoic acid type UV absorbers such as ethyl ester, N, N-dimethyl PABA butyl ester, anthranilate type UV absorbers such as homomenthyl-N-acetylanthranilate, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, Salicylic acid UV absorbers such as phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl
-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl
-α-Cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate and other cinnamic acid-based UV absorbers, 2, 4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy- 4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-
Benzophenone-based UV absorbers such as phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, 3- (4'-methylbenzylidene) -d, 1 -Camphor, 3-benzylidene-d, 1-camphor, urocanic acid, urocanic acid ethyl ester, 2-phenyl-5-methylbenzoxazole, 2,2'-hydroxy-5-methylphenylbenzotriazole, 2- (2 '-Hydroxy-5'-t-octylphenyl) benzotriazole, 2- (2'-hydroxy
-5'-methylphenylbenzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbornylidene) -3-pentan-2-one Etc. The ultraviolet scattering agent used in the present invention, titanium oxide, zinc oxide,
Examples include kaolin. Further, these titanium oxides and the like may be modified with silicone or the like. The blending amount of the ultraviolet absorber or the ultraviolet scattering agent used in the present invention is 0.01 to 30% by weight in the total amount of the external preparation for skin, preferably,
It is 0.1 to 20% by weight. If it is less than 0.01% by weight, the effect is not exhibited, and if it exceeds 30% by weight, it is not preferable for the product.

Glabridin according to the present invention has the following general formula

[Chemical 1] It is represented by. Further, the glabrene according to the present invention has the following general formula

[Chemical 2] It is represented by. The glabridin or glabrene used in the present invention may be either synthetically obtained or extracted from a plant. In the case of extraction, for example, an extract extracted with a solvent such as ethanol from the roots of licorice or other plants of the same genus may be used, or a powder obtained by removing the solvent from the extract may be used. The amount of glabridin or glabrene used in the present invention is 0.001 to 3.0% by weight as a dry solid content in the total amount of the external preparation for skin,
It is preferably 0.005 to 0.5% by weight. If it is less than 0.001% by weight, it tends to be impossible to sufficiently prevent the skin from being roughened by ultraviolet rays, stains and freckles.

In addition to the above essential constituents, the external preparation for skin of the present invention may optionally contain other components which are usually used in external preparations for skin such as pharmaceuticals and cosmetics, such as liquid paraffin, petrolatum and microcrystalline wax. , Squalane, almond oil, olive oil, hydrogenated oil, castor oil,
Oil components such as syrup, coconut oil, beeswax, lanolin, carnauba wax, palm oil, lanolinic acid, myristic acid, palmitic acid, fatty acids such as stearic acid, isostearic acid, oleic acid, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, cholesterol Higher alcohols such as isopropyl myristate,
Esters such as myristyl myristate, isopropyl palmitate, acids such as citric acid, tartaric acid, lactic acid, alkalis such as sodium hydroxide, potassium hydroxide, triethanolamine, lauryl dimethylaminoacetic acid betaine, glyceryl monostearate, sorbitan fatty acid Ester, polyoxyethylene fatty acid ester, surfactant such as polyoxyethylene alkyl ether, glycerin,
Propylene glycol, 1,3-butylene glycol,
Moisturizers such as dipropylene glycol, sorbitol, sodium pyrrolidonecarboxylate, polyethylene glycol, hyaluronic acid, glycine, serine, cystine, alanine, cysteine, amino acids such as aspartic acid, glutamic acid, arginine, lysine, acylglutamic acid,
L-arginine L-aspartate, acyl-β-alanine, amino acid derivatives such as glutathione, powders such as talc and calcium carbonate, antiseptic disinfectant such as paraben, thickeners such as carboxymethyl cellulose, sodium alginate and carboxyvinyl polymer , Colorants such as yellow iron oxide, titanium yellow, carmine, photosensitizer, carrot, aloe, mallow, iris, grape, yokuinin, melissa, yarrow, loofah, lily, oak, peony, yellowtail, birch, loquat, etc. ,
Vitamins such as nicotinic acid amide can be added. Of course, these components must be used within a qualitative and quantitative range that does not impair the effects of the present invention.

The dosage form of the external preparation for skin of the present invention is arbitrary,
Solution system, solubilization system, emulsion system, powder dispersion system, water-two-layer system,
Any formulation such as water-oil-powder three-layer system may be used.
In addition, the application of the external preparation for skin of the present invention is also optional, such as lotion, emulsion, cream, facial cosmetics such as packs,
It can be used for makeup cosmetics such as foundations, lipsticks and eye shadows, body cosmetics, aromatic cosmetics and the like.

[0009]

The external preparation for skin of the present invention has a high ultraviolet blocking effect and is excellent in preventing rough skin, spots and freckles caused by ultraviolet rays.

[0010]

EXAMPLES The present invention will be specifically described with reference to Examples. The present invention is not limited to this. The blending amount is% by weight. Regarding the degree of skin roughness, the samples are cumulatively applied to compare the skin conditions immediately before the start of the test and after one month has elapsed with a replica of the skin using the replica method using myristin resin and observed under a microscope. I went by.

Rough skin test by ultraviolet rays In the summer (July-August), one group of 20 subjects, which are often exposed to ultraviolet rays, is used as one group, and one kind of sample cream is used in the morning.
It was applied to the face every day for a month, and the degree of rough skin in the first month was compared with that immediately before the start of the test. The judgment criteria are shown in Table 1, and the study prescriptions are shown in Table 2. The formulations in Table 2 were manufactured by a conventional method. Table 3 shows the results of the test for preventing rough skin, stains and freckles by cumulative application.

[0012]

[Table 1]

[0013]

[Table 2]

[0014]

[Table 3]

As is clear from Table 3, the examples of the present invention are excellent in the effect of preventing skin roughness, spots and freckles caused by UV irradiation.

Example 2 Lotion A lotion was prepared by a conventional method according to the following formulation. Ethanol 10.0 Polyoxyethylene (20 mol) oleyl ether 0.3 Methyl paraoxybenzoate 0.1 Perfume Suitable amount 1,3-butylene glycol 5.0 Grabridine 0.01 Sodium hydroxymethoxybenzophenone sulfonate 0.1 Lactic acid 0.2 Sodium metaphosphate 0.05 Colorant Suitable amount Ion-exchanged water Remaining amount

Example 3 Emulsion An emulsion was prepared by a conventional method according to the following formulation. Cetanol 0.8 Cetostearyl alcohol 1.4 Liquid paraffin 3.0 Guaiazulene 0.1 Octyl methoxycinnamate 0.5 Sorbitan monostearate 0.5 Self-emulsifying glyceryl monostearate 1.0 Polyoxypropylene stearyl ether 0.5 Stearic acid 0.5 Ethyl paraoxybenzoate 0.2 Grabrene 0.05 Glycerin 1.0 Hyaluronic acid Sodium 0.1 Nicotinamide 0.1 Potassium hydroxide 0.15 Fragrance Suitable amount Ion-exchanged water Remaining amount

Example 4 Cream A cream was produced by a conventional method according to the following formulation. Squalane 8.0 Stearic acid 3.0 Stearyl alcohol 3.0 Self-emulsifying glyceryl monostearate 6.0 Beeswax 3.0 Hydroxymethoxybenzophenone 1.0 Ethyl paraoxybenzoate 0.2 Licorice extract 0.125 (Dry solids 0.05) Propylene glycol 5.0 Triethanolamine 1.0 Melissa extract 0.05 Ion-exchanged water residue amount

Example 5 Sun Care Sun care was prepared by a conventional method according to the following formulation. Octyl methoxycinnamate 10.0 Tetrahydroxybenzophenone 2.0 Stearic acid 4.0 Cetanol 1.0 Isocetyl stearate 1.0 Isodecyl pivalate 5.0 Ergocalciferol 0.1 Ethyl paraoxybenzoate 0.2 Perfume Adequate amount Dipropylene glycol 5.0 Grabridine 0.2 Triethanolamine 0.1 Ion-exchanged water Remaining amount

Example 6 Foundation According to the following formulation, a foundation was produced by a conventional method. Liquid paraffin 5.0 Myristyl myristate 2.0 Polyisobutene 2.0 Oleyl alcohol 2.0 Stearyl alcohol 2.0 Polyoxyethylene sorbitan oleate 0.5 Octyl methoxycinnamate 3.0 Butyl paraoxybenzoate 0.1 Perfume Fragrance Talc 5.0 Titanium oxide 5.0 Iron oxide 4.0 Aluminum magnesium silicate 0.75 Grabrene 0.4 Potassium hydroxide 0.05 Xanthan gum 0.15 Glycerin 4.0 Citric acid 0.3 Ion-exchanged water Remaining amount The external preparations for skin of Examples 2 to 6 were excellent in the effect of preventing rough skin due to ultraviolet rays.

Continuation of the front page (51) Int.Cl. ⁵ Identification code Office reference number FI technical display location A61K 7/48 9051-4C

Claims (1)

[Claims] 1. A skin external preparation containing an ultraviolet absorber and / or an ultraviolet scatterer and glabridine and / or glabrene.