JPH06242127A - Automatic analysis device - Google Patents

Abstract

PURPOSE:To provide an automatic analysis device which eliminates cross contamination between samples or reagents by providing a pipette tip corresponding to the number of individual containers in an autosampler holding individual containers and a reagent table. CONSTITUTION:Pipette tips 1A of an equal number to that of sample containers 1 are arranged on the outer circumference side of a sample container holding part in an autosampler freely removably. A pipette 11 is mounted by the tip 1A in the position W1, sucks a sample from the container 1 in the position (a), pipettes the sample to a reaction container B in the position (b), disposes of the tip away in the position W2, and is turned to the position W1. The tip 1A is discarded in the position W2 after use. On the other hand, tips 23A of an equal number are arranged on the outside of the container 23 of the first reagent pipetting device freely removably. The tips 23A are returned to a holding position y1 after use without discarding as they are dedicated for its own use. Pipette tips 33A dedicated for the second reagent are handled similarly to the tips 23A while pipette tips 122A for a measurement liquid are handled similarly to the tips 1A. In this way, cross contamination between the samples and the reagents is eliminated completely.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer for performing biochemical analysis, immunological analysis, etc., and more particularly, to an automatic analyzer capable of reducing cross-contamination between samples or reagents to "zero". Regarding analytical equipment.

[0002]

2. Description of the Related Art As is well known, in an automatic analyzer, a sample or a reagent is sucked with one or two pipettes and dispensed into a reaction container, and after this work is finished, the pipettes are washed. It is generally configured to suck the next sample or reagent.

In the method of cleaning such a pipette,
No matter how high the cleaning accuracy is, it is not possible to wipe off the sample or reagent adhering to the pipette, and the current situation is that cross-contamination occurs and the measurement accuracy is reduced. The magnetic particle method that sensitizes the surface of the antibody, the latex method that sensitizes the antibody on the surface of the latex, the bead method that sensitizes the antibody on the surface of the spherical beads, the coating method that coats the antibody on the inner wall surface of the cell, etc. The automatic immune analyzer has a problem that whether or not such cross-contamination can be made as close to "zero" as possible has a significant influence on the measurement accuracy.

As means for making this cross contamination "zero", for example, it is conceivable to arrange the same number of pipettes as the sample container and the reagent container, but in this case, the mechanism becomes very complicated, In addition, there is a problem that the device also becomes significantly large and the cost becomes high.

The present invention was devised in view of the present situation, and its purpose is to completely eliminate cross-contamination between samples or reagents without complicating the structure so much. The present invention is intended to provide an automatic analyzer that can

[0006]

In order to achieve the above object, in the present invention, a sample or a reagent is sucked through a pipette, and the sample or the reagent is dispensed into a predetermined reaction container. The technical premise is an automated analyzer consisting of
The present invention is characterized in that pipette chips corresponding to the number of each of the above-mentioned containers are arranged on an autosampler and a reagent table which hold each container in which the sample and the reagent are stored.

[0007]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in detail below with reference to an embodiment shown in the accompanying drawings.

An automatic analyzer A shown in FIG. 1 shows a case where the present invention is applied to an immunochemical automatic analyzer of an electrochemiluminescence method using magnetic particles. Of course, the automatic analyzer to which the present invention is applied is not limited to the one shown in the drawings, and can be applied to, for example, a known biochemical automatic analyzer and a known immune automatic analyzer not shown.

That is, the automatic immune analyzer A according to this embodiment has a reaction container body C in which five reaction containers B arranged in series are integrally formed, and a reaction in which a plurality of reaction container bodies C are stocked. A container stocker D, a reaction container body transfer device F for transferring the reaction container body C from the reaction container stocker D to the linear transfer path E, and each reaction container of the reaction container body C carried into the linear transfer path E B is the sample dispensing position b, the first reagent dispensing position c, the first stirring position d, the buffer cleaning liquid dispensing position e, the buffer cleaning liquid suction position f, the antibody liquid dispensing position g, and the second stirring position of the linear transfer path E. Position h · Antibody liquid suction position i ·
Cleaning liquid injection position j, third stirring position k, cleaning liquid suction position l
-Substrate liquid dispensing position m-Fourth stirring position n-Measuring liquid dispensing position p-Fifth stirring position q-Measuring liquid suction position r-Reaction container transfer device G for intermittent and sequential transfer to the reaction container body disposal position t When,
A sampling device H for sucking and dispensing a required amount of sample into the reaction container B at the sample dispensing position b of the straight transfer path E
And a first reagent dispenser I for dispensing and stirring a reagent into a reaction container B in which the sample is dispensed, and a second reagent dispenser for dispensing and washing a buffer washing solution / antibody solution into the reaction container B J
And a B / F separation / cleaning device K for injecting and aspirating washing water into the reaction container B, a substrate liquid dispensing device L for dispensing and stirring the substrate liquid in the reaction container B, and measurement in the reaction container B A measurement liquid dispensing and aspirating device M for dispensing the liquid into the luminescence measuring container N at the optical measurement position s after stirring and stirring, and a luminescent state of the sample introduced into the luminescence measuring container N The optical measuring device P for measuring, the discarding device Q for discarding the reaction container body after the measurement, and the measurement container holder T holding the luminescence measuring container N are arranged in the luminescence measuring container N in multiple stages. A cleaning device R for cleaning, and a control device S that drives and controls these devices in cooperation with each other and that processes the analysis data in a predetermined manner are configured.

The reaction container C is made of a light-transmitting material such as plastic which is flexible and has excellent reagent resistance, and is formed in a band shape. The reaction container B has a rectangular planar shape and a concave cross section. Are formed by injection, vacuum forming, or the like so that five pieces are formed. Of course, the number of reaction vessels B is not limited to this.

As shown in FIG. 1, the reaction container body C thus constructed is stored in the reaction container stocker D in a state in which a plurality of stacks (for example, a unit of 10) are stacked. Are erected in five rows in the illustrated embodiment.

The reaction container body transfer device F transfers the reaction container bodies C housed in the respective reaction container stockers D to a linear transfer path E.
It is configured to be sequentially transferred to the start end of the. Of course, although not shown, a lid for preventing evaporation of the sample is removably attached to the upper opening of the linear transfer path E, and the lid is for the transfer of the reaction container body C. It is mounted on the straight transfer path E so as not to interfere, and
Each sample dispensing position b, first reagent dispensing position c, first stirring position d, buffer cleaning liquid dispensing position e, buffer cleaning liquid suction position f, antibody liquid dispensing position g, second stirring position h, antibody liquid suction Position i, cleaning liquid injection position j, third stirring position k, cleaning liquid suction position l, substrate liquid dispensing position m, fourth stirring position n, measurement liquid dispensing position p, fifth stirring position q, measurement liquid suction position r A small hole for supplying a sample, a reagent and the like and a small hole for inserting a stirring rod and a sample suction pipette are provided in the.

Each reaction container B of the reaction container body C thus transferred to the linear transfer path E is transferred to the sample dispensing position b, and at the sample dispensing position b, via the sampling device H. A required amount of sample is sucked from the sample container 1 that has reached the sample suction position a and dispensed into the reaction container B.

A predetermined number of the sample containers 1 are held on an endless belt, and the sample containers 1 are sequentially and intermittently transferred to a sample suction position a by an auto sampler (not shown) having a known feeding mechanism. ing.

On the outer peripheral side of the sample container holding portion of this auto sampler, the same number of sampling pipette chips 1A as the sample containers 1 are detachably arranged.

Each holding position w ₁ of the sampling pipette tip 1A is set so as to be located on the rotation trajectory of the sampling pipette 11, and the pipetting tip 1A is used after the tip discarding position w ₂
Be discarded at. Of course, although not shown, a new sampling pipette chip 1A is automatically supplied to the holding position of the sampling pipette chip 1A where the sampling pipette chip 1A has been discarded by a chip supply device configured by a known pickup robot or the like. To be done.

As the auto sampler for transferring the sample container 1, known turntable type or rack type mechanisms can be appropriately adopted.

The sampling device H is connected to the arm 10 whose one end is rotatably supported by a shaft, the sampling pipette 11 arranged at the other end of the arm 10 and the sampling pipette 11 so that a required amount of sample can be collected. The pump 15 for sucking and discharging to the reaction container B and the arm 10 are rotated at a predetermined timing from the pipette tip holding position w ₁ to the sample suction position a to the sample dispensing position b to the tip discarding position w ₂ . Each drive device (not shown) that controls and raises and lowers the sampling pipette 11 at each position. A reader device Y for reading an ID number such as a bar code label attached to the sample container 1 is provided at the sample suction position a.

That is, the sampling pipette 11 is
First, rotated into the pipette tip holding position w _1, decreasing at the position w _1, after fitted sampling pipette tip 1A to the tip, rises and rotates to the sample suction position a, At a position a, the sample container 1 is lowered to aspirate a required amount of sample from the sample container 1 and then ascends, and thereafter is rotated to be transferred to a sample dispensing position b and is lowered at the position b to be sucked. after dispensed into the reaction vessel B was a specimen sample to be elevated is transferred to the tip disposal position w _2, in the position w _2, after withdrawal of the sampling pipette tip 1A, again the pipette tip holding position The drive is controlled so as to rotate to w ₁ . Of course, the sampling pipette chip 1A is configured to have a capacity capable of aspirating the maximum amount of sample sample aspirated by the sampling pipette 11, and is configured so that the sample sample is not aspirated into the sampling pipette.

The above sampling pipette tip 1A
In order to maintain the fitting state between the sampling pipette 11 and the sampling pipette 11 in a liquid-tight manner, in this embodiment, water is interposed at the joint between the sampling pipette tip 1A and the sampling pipette 11.

The first reagent dispensing device I is connected to the arm 20 whose one end is pivotally supported by a shaft, the first reagent pipette 21 arranged at the other end of the arm 20, and the first reagent pipette 21. Connected to the reaction vessel B by sucking the required amount of the first reagent
A pump (not shown) for discharging to the first reagent pipette tip holding position y ₁ from the first reagent pipette tip holding position y ₁ to the first reagent aspirating position u, and again from the first reagent dispensing position c to the first reagent pipette tip holding position. Each drive device (not shown) that controls rotation to y ₁ at a predetermined timing and that controls the arm 20 to move up and down at each position, and an agitator 22 held by the arm 20. Has been done.

The first reagent pipette 21 is for dispensing the antibody-insoluble magnetic body liquid, which is the first reagent, into the reaction container B in which the sample is dispensed. The antibody-insoluble magnetic body liquid is arranged in a loop (radially). In addition to being housed in any of the plurality of first reagent containers 23, the same number of first reagent-dedicated pipette chips 23A are detachably arranged on the outer peripheral side of the first reagent containers 23.

This first reagent dedicated pipette tip 23A
Unlike the sampling pipette tip 1A, is not discarded after use, but is used exclusively for each first reagent container 23, so that after use, it is returned to the first reagent pipette tip holding position y ₁ . The first reagent pipette tip holding position y ₁ is set so as to be located on the rotation trajectory of the first reagent pipette 21.

Therefore, the reaction vessel B is located at the first reagent dispensing position c.
When the first reagent pipe 23 reaches the reagent suction position u, the first reagent container 23 accommodating the first reagent corresponding to the specimen sample in the reaction container B is transferred to the reagent suction position u.
First pivots to the first reagent pipette tip holding position y ₁ and descends, fits and holds the first reagent dedicated pipette tip 23A at its tip, and then ascends to pivot to the reagent suction position u. Then, after descending at the position u and sucking a required amount of the first reagent corresponding to the measurement item, the first reagent dispensing position c
To the first reagent pipette tip holding position y ₁ after dispensing the first reagent sucked from the first reagent pipette 21 into the reaction container B at the first reagent dispensing position c. It is rotated and controlled to drop at the position y ₁ to the place where the first reagent-dedicated pipette chip 23A is fitted, rise again, and stand by. In this case, in order to facilitate the fitting or removal of the first reagent-dedicated pipette chip 23A, for example, the tip portion of the first reagent pipette 21 is configured to be expandable and contractable by applying a known mechanism. desirable.

The antibody-insoluble magnetic substance is obtained by sensitizing an antibody to a known magnetic fine particle, and the antibody-insoluble magnetic substance is not shown in the figure but reacts through a magnetic substance adsorbent composed of an electromagnet or a permanent magnet. Adsorbed on the inner surface of the container B. This magnetic adsorbent is arranged at, for example, a buffer cleaning liquid suction position f, an antibody liquid suction position i, a cleaning liquid suction position l, and a measurement liquid suction position r.

The first reagent container 23 provided in the reagent holder is set at predetermined positions, and these positions are stored in the controller S. Also,
Since the specific gravity of the antibody-insoluble magnetic substance liquid of the above-mentioned antibody-insoluble magnetic substance liquid is large, if it is left standing, it will settle to the bottom of the container, which will cause variation in measurement accuracy, so stir the antibody-insoluble magnetic substance liquid by appropriate means. It is desirable to do.

The stirrer 22 dispenses the first reagent into the first
The sample in the reaction container B that has reached the stirring position d is stirred, and is transferred in conjunction with the first reagent pipette 21.

A stirring rod (not shown) of the first reagent pipette 21 and the stirring device 22 is disposed at a washing position (position) between the first reagent suction position u and the first reagent dispensing position c. It is cleaned with (not shown) to prevent cross contamination. Further, since the detailed configurations of the first reagent pipette 21 and the stirring device 22 are the same as those used in a known biochemical / immunity automatic analyzer, detailed description thereof will be omitted here.

The second reagent dispenser J dispenses a required amount of the buffer solution, which is the washing solution, at the buffer dispensing position e into the stirred reaction vessel B in which the first reagent has been dispensed, and the buffer solution is dispensed. Aspirate the poured sample at the buffer cleaning solution suction position f,
An enzyme-labeled antibody solution that is a second reagent is dispensed at the second reagent dispensing position g, and the sample into which the second reagent has been dispensed is stirred at the second stirring position h, and one end of which is an axis. Supported arm 3
0, a second reagent pipette 31 disposed at the other end of the arm 30, and a pump which is connected to the second reagent pipette 31 and communicates with the second reagent pipette 31 to aspirate a required amount of the second reagent and discharge it to the reaction container B ( (Not shown), the arm 30 is moved from the second reagent pipette tip holding position y ₂ to the first reagent suction position v, and then from the second reagent dispensing position h to the second reagent pipette tip holding position y ₂ . The drive device (not shown) that controls the rotation at the timing and that controls the raising and lowering of the arm 30 at each position, the stirring device 32 held by the arm 30, and the arm 30 integrally. It comprises a buffer cleaning liquid dispensing pipette 34 and a buffer cleaning liquid suction pipette 36 which are held.

The buffer cleaning liquid dispensing pipette 34 and the buffer cleaning liquid suction pipette 36 are the buffer pump 3 described above.
A buffer solution, which is a cleaning solution, is dispensed into the reaction container B located at the buffer dispensing position e via the liquid container 7, and a required amount of the diluted sample is aspirated and discarded from the reaction container B located at the buffer cleaning solution suction position f. Then, the second reagent pipette 31 and the stirrer 32 are interlocked and transferred.

The second reagent pipette 31, the second reagent-dedicated pipette tip 33A detachably attached to the tip of the second reagent pipette 31, the stirring device 32, the arm 30, and the reagent holder are set. The configuration, action, and transfer control of the second reagent container 33 that is used are the same as in the case of the first reagent dispensing apparatus I, so a detailed description thereof will be omitted here. In addition, the above-mentioned buffer solution is dispensed according to the above 1
Omitted in case of step method.

The B / F separation cleaning device K is a device for sucking the antibody solution in the reaction container B, and then injecting cleaning water and stirring the solution.
An arm 100, one end of which is axially supported, and this arm 10
0 is provided with the antibody liquid suction pipette 101, the washing liquid injection pipette 102, and the stirring device 103, and the arm 100 has the antibody liquid suction position i.
Washing liquid injection position j, third stirring position k, antibody liquid suction pipette 101, washing liquid injection pipette 102, stirring device 103
Reciprocally rotate between the washing position (not shown) of the stirring rod of
Elevation control is performed at each of these positions. The antibody liquid suction pipette 101 and the washing liquid injection pipette 102 suck the antibody liquid and supply the washing liquid through a washing pump (not shown). In addition, the stirring device 103 and the arm 10
Since the configuration and operation control of 0 are the same as those of the first reagent dispensing apparatus I, detailed description thereof will be omitted here.

The substrate liquid dispenser L dispenses the substrate liquid into the reaction vessel B and stirs it. The arm 110 has one end axially supported by the shaft and the other end of the arm 110. The cleaning liquid suction sampling pipette 111, the substrate liquid injection sampling pipette 112, and the agitator 113 are provided.
The substrate solution injection position m / the fourth agitation position n and the washing liquid suction sampling pipette 111 / the substrate liquid injection sampling pipette 112 / the agitation rod washing position (not shown) of the agitation device 113 are reciprocally rotated and these Lifting control is performed depending on the position. The cleaning liquid suction sampling pipette 111 and the substrate liquid injection sampling pipette 112 suck the cleaning liquid and supply the substrate liquid through a substrate liquid dispensing pump (not shown). In addition, the stirring device 113 and the arm 1
Since the configuration and operation control of 10 are the same as those of the first reagent dispensing apparatus I, detailed description thereof will be omitted here.

The measuring liquid dispensing / suction device M dispenses and stirs the measuring liquid, which is a reaction stopping liquid, into the reaction vessel B, and has an arm 120 whose one end is axially supported by the shaft and another arm 120. It is composed of a measurement liquid dispensing pipette 121, a stirring device 123, and a measurement liquid suction pipette 122 arranged at the end.

The arm 120 is provided with a measuring liquid dispensing position p.
The fifth stirring position q / measurement liquid suction position r and the measurement liquid dispensing pipette 121, the stirring rod of the stirring device 123, and the cleaning position (not shown) of the measurement liquid suction pipette 122 are reciprocally rotated, and these Lifting control is performed depending on the position. The measurement liquid dispensing pipette 121 and the measurement liquid suction pipette 122 dispense and suck the measurement liquid via a measurement liquid dispensing pump (not shown) and a suction pump 126. The configurations and operation controls of the stirring device 123 and the arm 120 are the same as those of the first reagent dispensing device I, and thus detailed description thereof will be omitted here.

The measuring liquid suction pipette 122 is located in front of the measuring liquid suction position r before it is rotated to the measuring liquid suction position r.
2A is fitted and held at the chip supply position z ₇ , and thereafter, it is rotated from the chip supply position z ₇ to the measurement liquid suction position r, and a required amount of the measurement liquid is sucked at the position r, after which it is rotated. Then, the measurement liquid is discharged into the luminescence measurement container N, and after the work is completed,
It is configured so that it is rotated to the tip discarding position z ₈ and the used measuring solution pipette tip 122A is discarded at this position z ₈ . Since the structure and operation of the measurement liquid pipette tip 122A and the structure of the automatic replenishing device and the like are the same as those of the sampling pipette chip 1A, detailed description thereof will be omitted here.

The sample sucked by the measuring liquid suction pipette 122 at the measuring liquid suction position r in this way is discharged into the luminescence measuring container N held in the measuring container holder T and optically measured.

That is, the measuring container holder T holds six luminescent measuring containers N in a loop at predetermined intervals in the illustrated embodiment, and as shown in FIG. 3, near the bottom of each container holding hole 130. Is provided with a power supply device 131 for applying a direct current, and at the bottom of each container holding hole 130, a magnet 132 for adsorbing the antibody-insoluble magnetic substance mixed in the luminescence measurement container N is provided. It is arranged. In the figure,
Reference numeral 138 is a condenser lens.

The measuring container holder T is, for example,
The position of z _{1 to} z ₆ is intermittently transferred at a predetermined timing via a known driving device (not shown) such as a pulse motor, and the measurement liquid is discharged at the z ₁ position.
At the z ₂ position, measurement with a photomultiplier tube (also called a multiplier) 137 is performed, and measurement from the z ₃ position to z ₄ is performed.
At the position and the z ₅ position, washing work with hot water at 80 ° C. is performed in three stages, and at the z ₆ position, the buffer solution is dispensed,
The luminescence measuring container N which has reached the z ₆ position and into which the buffer solution has been dispensed is then stepwise transferred from the z ₆ position to the z ₂ position, and the luminescence measuring container N is reserved by the photomultiplier tube 137. The measurement is taken.

This preliminary measurement value is used as a correction value for the measurement value of the measurement liquid by the photomultiplier tube 137 in the automatic immune analyzer A according to this embodiment.

Since the cleaning mechanism has the same structure as a known cleaning mechanism having a heating means for generating hot water, detailed description thereof will be omitted here.

The magnet 132 is a permanent magnet or an electromagnet. In this invention, in order to make the adsorption distribution of the antibody-insoluble magnetic material uniform and the excitation of the antibody-insoluble magnetic material uniform, the magnet 132 is horizontally reciprocated or eccentrically rotated. It can also be configured as follows.

The electrodes 135 of the power supply device 131,
For example, the slip ring 139 shown in FIG.
A direct current is supplied via. The position to which the direct current is applied is, as shown in FIG.
The sample is supplied only to the measurement position z ₂ in which the photomultiplier tube 137 is arranged on the upstream side of the sample dispensing position z ₁ by 26 for one container.

Although not shown, the measurement container holder T is arranged in a dark chamber, and a shutter is attached to the dark chamber so that the measurement liquid suction pipette 122 can be opened and closed. And the above photomultiplier tube 1
It is configured so that the measurement by 37 can be reliably performed. Of course, on the head side of the photomultiplier tube 137, a shutter (not shown) for preventing damage to the amplification circuit of the photomultiplier tube 137 when the dark room is opened is synchronized with the opening / closing operation of the dark room. It is arranged so as to open and close.

In addition, at the bottom of each luminescence measuring container N,
As shown in FIGS. 2 and 3, the comb-shaped electrodes 133 and 134 are formed.
The other ends of the electrodes 133 and 134 are formed so as to extend to the bottom of the outer peripheral surface of each luminescence measurement container N. Of course, the electrodes 133 and 134 extending to the outer peripheral surface of the luminescence measurement container N may be formed in a socket shape or may be formed in a connector shape.

Therefore, when each luminescence measurement container N is mounted in each container holding hole 130 of the measurement container holder T, the antibody-insoluble magnetic substance mixed in the luminescence measurement container N is magnetized by the magnetic force of the magnet 132. Is adsorbed to the bottom of the
When the electrodes 135 and 136 of the power supply device 131 are applied, the antibody-insoluble magnetic material mixed in the luminescence measurement container N is excited.

Since the construction of the photomultiplier tube 137 for measuring the electroluminescence and the quantitative measurement method by the photon counting method are known, detailed description thereof will be omitted here. In the case of optical measurement corresponding to the CL method, for example, polystyrene beads are used as a solid-phase carrier, the polystyrene beads are coated with an antibody or an antigen, the reaction vessel B is sealed, and the antigen is determined by the sandwich method. In the case of measuring, the target component (antigen) in the sample is reacted with an antibody coated on polystyrene beads to form a solid-phased antibody-antigen, and then other components in the sample are washed away to remove acridi After adding a nitric acid-labeled antibody and reacting it to form a solid-phased antibody-antigen-labeled antibody, the unreacted labeled antibody is washed off and the immobilized luminescent substance is allowed to emit light to perform the photon counting method. Quantitatively measure with.

In the above embodiment, optical measurement is performed by EIA.
Although the case of performing the method according to the method has been described as an example, when measuring and analyzing the latex agglutination reaction, it is optically measured by a known immunoturbidimetric method or a light scattering method.

Further, in the case of performing optical measurement corresponding to the ECL method, first, divalent ruthenium.
A tris-bi-pyridyl compound (hereinafter referred to as a Ru compound) is oxidized on the electrode surface (not shown) composed of the working electrode and the counter electrode arranged in the luminescence measuring container N to be in a trivalent state. At this time, the T present in a large excess in the sample
PA (tri-propylaminamine) is also simultaneously oxidized by the above electrode and converted into TPA cation radical.
The TPA cation radical is very unstable and releases a proton in a short time to change into a strong reducing agent TPA radical. The trivalent Ru compound is reduced by the TPA radical to be converted into a divalent Ru compound in the excited state, and photons emitted during the process in which this substance returns to a stable state are provided with PMTs arranged above the luminescence measuring container N. And then the electrode surface is electrochemically washed with an alkaline solution and a condition buffer. In this case,
A reference electrode for controlling the excitation potential is incorporated in the luminescence measurement container N.

The discarding device Q sequentially discards the reaction container bodies C which have been subjected to the optical measurement for the five reaction containers B formed in the reaction container bodies C. , Is dropped and stored in the reaction container body recovery container disposed at the reaction container body disposal position t.

The control device S controls the drive of the above-mentioned devices / mechanisms in cooperation with each other, and arithmetically processes the analysis data in a predetermined manner. The light received by the light receiving element is A /
The D-converted analysis value is sent to the control unit, and the analysis data is stored and saved in a storage unit (not shown).

Although not shown, the above devices and mechanisms are drive-controlled by a known readable / writable IC card.

This IC card has a readable integrated circuit. This integrated circuit is an electrically rewritable E-EPROM (Electrical Erasable Program).
ammable Read Only Memory),
The drive control means corresponding to the analysis items used in the facility where the automatic immune analyzer is installed are grouped and input, and the name, registration number, position, affiliation, etc. of the operator who uses the automatic analyzer are input. Various operation information is also entered.

[0054]

As described above, the present invention has an excellent effect that the cross contamination between samples or reagents can be completely "zero" without making the structure so complicated. Play.

[Brief description of drawings]

FIG. 1 is a plan view schematically showing the overall configuration of an automatic immune analyzer according to an embodiment of the present invention.

FIG. 2 is a cross-sectional view of a luminescence measuring container used in the same immunoassay analyzer.

FIG. 3 is a partial cross-sectional view of a measurement container holder to which the same luminescence measurement container is attached.

FIG. 4 is a perspective explanatory view showing a configuration example of a slip ring attached to the measurement container holder.

[Explanation of sign]

 A immuno-automatic analyzer B reaction container C reaction container body F reaction container body transfer device H sampling device I first reagent dispensing device J second reagent dispensing device N luminescence measurement container T measurement container holder 1A, 23A, 33A, 122A Pipette tip

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[Procedure amendment]

[Submission date] April 1, 1993

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0053

[Correction method] Change

[Correction content]

This IC card has a readable integrated circuit, and this integrated circuit is an electrically rewritable E-EPROM (Electrical E).
rasable Programmable Read
In addition, the drive control means corresponding to the analysis item used in the facility in which the immuno-automatic analyzer is installed are grouped and input, and the name of the operator who uses the analyzer. ,
Various operation information such as registration number, post, and department is also entered. In addition, the auto sampler is formed by a chain method.
The individual container holding the sample container
The tip holder has a hole for holding the pipette tip.
Opened individually, and pipette tips can be freely attached to and detached from this holding hole
It may be held.

Claims (1)

[Claims] 1. A sample or a reagent is aspirated through a pipette,
In the automatic analyzer configured to dispense the sample and the reagent into a predetermined reaction container, in the autosampler and the reagent table holding each container containing the sample and the reagent, the number of each container An automatic analyzer having a corresponding pipette tip.