JPH06242118A - Automatic analyzer and measuring method for accuracy management sample - Google Patents

Abstract

PURPOSE:To provide an automatic analyzer and a measuring method for an accuracy management reagent, by which the waste of a control sample and a reagent can be avoided and the whole measuring time for a tested body can be reduced by measuring an accuracy management sample efficiently. CONSTITUTION:An automatic analyzer comprises a measuring part 1 capable of measuring a tested body of a patient, an input part 2 capable of inputting a measuring condition, a control part 3 capable of controlling the respective parts, a storage part 5 capable of storing a measuring condition for an accuracy management sample input by the input part 2 for every accuracy management sample and a logical calculating part 6 for reading out the measurement item of two accuracy management samples of the same kind for the accuracy management sample from the storage part 5 and creating a new measurement item in such a manner that all the read-out measurement items are included and the same measurement item is not repeated.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an automatic analyzer and a method for measuring a quality control sample for measuring a quality control sample for inspecting the reliability and stability of the automatic analyzer.

[0002]

2. Description of the Related Art To measure a sample with an automatic analyzer, first, a calibration curve is prepared using a blank sample (sample having a concentration of zero) and a standard sample (sample having a known concentration). This is called calibration.

Next, in order to check whether or not the calibration was performed correctly, a quality control sample of known concentration is measured using a calibration curve, and it is confirmed whether the measured value matches the known concentration. The quality control sample used here is called a counter control sample.

Next, the sample is measured for a predetermined measurement item, but in order to ensure the accuracy of the measured value over a predetermined time, the sample of known concentration is measured before, after, and during the measurement of the sample at predetermined intervals. . The quality control samples used here are called start control sample, end control sample, and interval control sample, respectively.
These are collectively called a control sample for QC.

FIG. 5 (a) shows the samples measured in the calibration process arranged in the order of measurement.
(i = 1,2,3) is a blank sample, Si (i = 1,2,3) is a standard sample, and Ci (i = 1,2,3) is a counter control sample. Note that i is a number related to the type of sample.

FIG. 5 (b) shows a sample and a sample to be measured in the sample measuring step, which are arranged in the order of measurement.
si (i = 1,2,3) is the start control sample, Cei (i = 1,
2) is an end control sample, Cii (i = 1,2,3) is an interval control sample, and Pi (i = 1,2,3 ...) Is a patient sample.

By measuring the quality control sample for a predetermined measurement item in this procedure, the accuracy of the measured value of the sample can be ensured.

[0008]

Here, the counterattack control sample, the start control sample, the end control sample and the interval control sample are
As described above, each measurement is performed for a specific purpose, and therefore the measurement itself is important for the quality control of the sample measurement value.

However, when the type of quality control sample and the measurement items are the same, eventually, the same sample may be repeatedly measured for the same measurement item.

For example, the counter control sample and the start control sample are successively measured as can be seen in FIG. 5, so if the same kind of measurement items and the same measurement item exist in each measurement item,
The same measurement item will be measured redundantly. Also,
Since the interval control sample and the end control sample are continuously measured, the same situation occurs.

[0011] Such a situation not only wastes the sample and the reagent but also causes the measurement time to be long.

The present invention has been made in consideration of the above-mentioned circumstances, and by efficiently measuring a quality control sample, it is possible to avoid wasting control samples and reagents and shorten the total measuring time of the sample. An object of the present invention is to provide an automatic analyzer and a measuring method therefor.

[0013]

In order to achieve the above object, the automatic analyzer of the present invention, as described in claim 1, has a measuring section capable of measuring a quality control sample and a sample of known concentrations, and A storage unit capable of storing the measurement conditions of the quality control sample for each quality control sample, and the measurement items of at least two quality control samples of the same type and continuously or at a predetermined interval or less. And a logical calculation unit capable of creating a new measurement item so that all the read measurement items are included and the same measurement item does not overlap, and the measurement unit, For the new measurement item, at least 2
One of the above quality control samples is measured.

Further, according to the quality control sample measuring method of the present invention, as described in claim 2, in the quality control sample measuring method of measuring the quality control sample having a known concentration, the same kind of sample is used. In addition, the measurement items of at least two quality control samples that are measured continuously or at a predetermined interval or less are read, and new measurement items are included so that all the read measurement items are included and the same measurement items do not overlap. A measurement item is created, and one of the two or more quality control samples is measured for the created new measurement item.

[0015]

According to the automatic analyzer and the method for measuring quality control samples of the present invention, first, at least two quality control samples of the same type and continuously or at a predetermined interval or less are measured. Read each item. Next, a new measurement item is created so that all the read measurement items are included and the same measurement item does not overlap. Next, one of the two or more quality control samples is measured for the created new measurement item.

[0016]

EXAMPLES Examples of the automatic analyzer and the method for measuring quality control samples of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is an overall block diagram showing the automatic analyzer of the present embodiment.

As shown in the figure, the automatic analyzer of the present embodiment comprises a measuring unit 1 capable of measuring a sample of a patient, for example, serum.
An input unit 2 capable of inputting measurement conditions and a control unit 3 capable of controlling each unit are provided.

Although not shown, the measuring unit 1 samples the sample in the sample container with a sampling probe, then injects the sampled sample and a predetermined reagent into a reaction container to cause a reaction, and then performs a reaction. By measuring the absorbance of the product, the sample can be measured for a predetermined measurement item.

Here, the measurement value for a predetermined measurement item is calculated using a calibration curve prepared in advance.

The measuring unit 1 is also capable of measuring quality control samples having known concentrations, that is, blank samples, standard samples, counter control samples, start control samples, end control samples, and interval control samples.

The automatic analyzer of the present embodiment further has the same type of quality control sample as the storage unit 5 capable of storing the measurement conditions of the quality control sample input by the input unit 2 for each quality control sample. A logical calculation unit 6 capable of reading the measurement items of two quality control samples from the storage unit 5 and creating new measurement items so that all the read measurement items are included and the same measurement items do not overlap. The measurement unit 1 is configured to measure one of two quality control samples for a new measurement item.

Even if the two quality control samples have the same and common measurement items, if a large number of other samples or samples are measured between the two quality control samples, the time elapses. Since the influence due to can not be ignored, it is preferable that the two quality control samples are measured at a predetermined interval or less, and further, it is preferable that the two quality control samples be continuously measured. The predetermined interval may be set in advance such that the number of samples measured between two quality control samples is 3 or less, for example.

Next, the operation of the automatic analyzer of this embodiment will be described.

2 and 3 are flow charts showing the procedure for measuring a quality control sample using the automatic analyzer of this embodiment.

First, calibration is performed by measuring a blank sample and a standard sample (step 11).

Next, each measurement item of the counter control sample and the start control sample is read from the storage section 5 (step 12). Here, when the same type of sample does not exist in the counter control sample and the start control sample (step 13, No), the counter sample and the start control sample are measured for each measurement item (step 14).

If the same type of sample exists in the counter control sample and the start control sample (step 13, Yes), all the read measurement items are included and the same measurement items do not overlap. As described above, the logical calculation unit 6 creates a new measurement item (step 1
5).

FIG. 4A shows a counter control sample C.
c1, Cc1, Cc3 and start control sample Cs1,
When Cc1 and Cs1 of Cs2 and Cs3 are of the same type, new measurement items are created from the respective measurement items of Cc1 and Cs1 as described above, and the new measurement item is either Cc1 or Cs1. (This is Cc1 '
And) is measured.

FIG. 4 (b) is a diagram showing a state in which a new measurement item is created from the respective measurement items of Cc1 and Cs1, and Ti (i = 1,2,3,4,5) is measured. Item type is ○, ×
Indicates the presence or absence of measurement items.

As can be seen from the figure, the measurement items for Cc1 are T1 and T4, and the remaining T2, T3, and T5 are not included in the measurement items. On the other hand, the measurement items for Cs1 are T2, T3, and T4, and the remaining T1 and T5 are not included in the measurement items. Therefore, new measurement items for Cc1 'are T1, T2, T3, and T4.

Referring again to FIG. 2, one of the above-mentioned samples is measured for the newly created measurement item (step 16). In the above example, either Cc1 or Cs1 is measured. Also, different types of Cs2, Cs3, C
s2 and Cs3 for each measurement item, for example, Fig. 4 (a)
Measure in the order shown in.

Next, the specimen sample is measured while measuring the interval control sample at a predetermined interval (step 17).

After all the specimen samples have been measured (step 1
8, Yes), as shown in FIG. 3, the measurement items of the interval control sample and the end control sample are read from the storage unit 5 (step 19). Here, if the same type of sample does not exist in the interval control sample and the end control sample (step
20, No), interval control sample and end control sample are measured for each measurement item (step 21).

When the same type of sample exists in the interval control sample and the end control sample (step 20, Yes), all the read measurement items are included and the same measurement item does not overlap. As described above, the logical calculation unit 6 creates a new measurement item (step 2).
2). Next, one of the above-mentioned samples is measured for the created new measurement item (step 23).

The procedure for creating a new measurement item is as follows.
The description is omitted here because it is almost the same as that described above.

As described above, the automatic analyzer of the present embodiment pays attention to two control samples of the same kind which are measured continuously or at a predetermined interval or less, and the measurement items for these control samples are logically determined. As a result, a new measurement item is created and one of the above-mentioned control samples is measured for the created measurement item. It can be measured quickly.

Therefore, it is possible to avoid wasting the control sample and the reagent, and it is possible to shorten the test time of the sample.

Further, it becomes possible to surely perform the measurement of the required control sample, and it is possible to improve the accuracy of the measurement result.

Further, since the storage unit and the logical calculation unit are configured to automatically perform such an operation, it is possible to reduce the operation load on the operator and at the same time avoid the QC management error in advance.

Further, the method of defining a new selection item using the selection items of two quality control samples simply logically ORs the measurement item information, and therefore Improves reliability.

Although not described in the above-mentioned embodiment, when the number of times of measurement of the two quality control samples is different, it may be adjusted according to a preset condition, for example, one having a large number of measurements or one having a small number of measurements. In that case, first, the new measurement item may be measured only a small number of times, and then the measurement item of the large number may be measured by the difference between the large number and the small number.

Further, in the above embodiment, the logical sum of the measurement items of the two quality control samples is taken, but the logical sum of the measurement items of three or more quality control samples may be taken. .

In the above-described embodiment, the case where the end control sample is measured after the interval control sample is assumed, but in such a case, the total number of patient samples is just a multiple of the interruption interval of the interval control sample. Normally,
The end control sample is measured immediately after measuring the sample. In such a case, there is no possibility of duplicate measurement of the same type of control sample, so there is no room to apply this example.

[0045]

As described above, the automatic analyzer of the present invention has a measuring unit capable of measuring a quality control sample and a sample having known concentrations, and measuring conditions of the quality control sample for each quality control sample. A storable storage unit reads out from the storage unit the measurement items of at least two quality control samples that are of the same sample type and that are measured continuously or at predetermined intervals or less, and the readout measurement A logical calculation unit capable of creating a new measurement item so that all the items are included and the same measurement item is not duplicated, and the measurement unit performs the quality control of the at least two or more for the new measurement item. Since one of the samples is measured, it is possible to efficiently measure the quality control sample, avoid waste of control samples and reagents, and shorten the total measurement time of the sample. Rukoto can.

Further, as described in claim 2, the quality control sample measuring method of the present invention is the same as the quality control sample measuring method of measuring a quality control sample having a known concentration. In addition, the measurement items of at least two quality control samples that are measured continuously or at a predetermined interval or less are read, and new measurement items are included so that all the read measurement items are included and the same measurement items do not overlap. Since the measurement item is created and one of the two or more quality control samples is measured for the newly created measurement item, it becomes possible to efficiently measure the quality control sample, and the control sample is obtained. It is possible to avoid wasting reagents and reagents and shorten the total measurement time of the sample.

[Brief description of drawings]

FIG. 1 is a block diagram of an automatic analyzer according to the present embodiment.

FIG. 2 is a flowchart showing a procedure for measuring a quality control sample using the automatic analyzer of the present embodiment.

[FIG. 3] Same as above

[FIG. 4] (a) shows that new measurement items are created from the measurement items of Cc1 and Cs1 that are the same type among the continuous control sample and the counter control sample, and Cc1 and Cs1 for these measurement items are created. The figure showing how to measure Cc1 ', which is one of the two.
FIG. 5 is a diagram showing a state in which a new measurement item is created from the measurement items of Cs1.

FIG. 5A is a diagram showing a calibration process,
(b) is a figure showing a sample measurement process.

[Explanation of symbols] 1 measuring unit 2 input unit 3 control unit 5 storage unit 6 logical calculation unit

Claims (2)

[Claims] 1. A measuring unit capable of measuring a quality control sample and a sample of known concentrations, a storage unit capable of storing the measurement conditions of the quality control sample for each quality control sample, and the same type of sample. Measurement items of at least two quality control samples that are measured continuously and at a predetermined interval or less are read from the storage unit, and the same measurement item is duplicated so that all read measurement items are included. A logical calculation unit capable of creating a new measurement item so that the measurement unit measures at least one of the at least two quality control samples for the new measurement item. An automatic analyzer characterized in that 2. A quality control sample measuring method for measuring a quality control sample having a known concentration, wherein at least two quality control samples of the same type and measured continuously or at a predetermined interval or less. Each measurement item is read, a new measurement item is created so that all the read measurement items are included and the same measurement item does not overlap, and the accuracy of the above two or more is created for the created new measurement item. A method for measuring a quality control sample, which comprises measuring one of the control samples.