JPH06113Y2 - Flexible bag - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to an improvement of a flexible bag whose flexible bag body is made of ethylene-vinyl acetate copolymer.
In particular, the present invention relates to a flexible bag in which at least one sheet constituting the bag body is made smooth so that the bag body has a transparent feeling so that the inside of the bag body can be easily seen.

INDUSTRIAL APPLICABILITY The flexible bag of the present invention can be applied to any flexible bag that encloses cells such as plants and animals in addition to the drug solution.

[Problems to be Solved by Prior Art and Invention] An infusion solution bag is used as a flexible bag made of an ethylene-vinyl acetate copolymer. These infusion bags are formed with the content of vinyl acetate set to 19% in order to maintain flexibility, but the heat generated during EOG sterilization blocks the inner surfaces of the sheets forming the bag body from blocking each other. There was an inconvenience that it was easy to do. In order to avoid this, ribs were formed on the inner surface of the sheet, but the ribs impaired the transparency of the bag body, making it difficult to see through the inside.

For this reason, if minute dusts are mistakenly entered in the bag body, they cannot be detected, and if a transparent drug solution is enclosed in the bag body, it is difficult to check the liquid level, and it is difficult for the patient. In some cases, there was an excess or deficiency in the amount of drug solution to be infused, and stable infusion could not be performed. Therefore, as a result of intensive studies, the present inventors have arrived at the next invention.

[Means for Solving the Problems] A flexible bag body 2 and a liquid transfer tube 3 mounted on the body 2, and the bag body 2 is made of an ethylene-vinyl acetate copolymer. The bag 1 and the bag body 2
The first sheet 10 constituting the sheet has a vinyl acetate content of 5 to 1
5% outer layer sheet 12 and vinyl acetate content 16-20%
The outer layer sheet 12 and the inner layer sheet 13 have smooth surfaces, and the second sheet 11 constituting the bag body 2 has a vinyl acetate content of 15 to
The second sheet 1 composed of a 35% single layer sheet
The inner side of the bag 1 provides a flexible bag 1 in which ribs 21 are formed.

[Operation] Since the inside of the bag body 2 is improved in transparency and the inside of the bag body 2 is easily visible, it is easy to confirm the remaining amount of the drug solution in the bag body 2, the cell growth level, and the like.

[Examples] FIG. 1 is a schematic view of a flexible bag 1 used as a high-calorie infusion bag, and FIG. 2 is a partially enlarged view of a sectional view taken along the line AA of FIG.

The flexible bag 1 is composed of a bag body 2 made of an ethylene-vinyl acetate copolymer, a flexible drug solution injection tube 3 mounted on the upper part of the body 2 and an infusion port 7. A tube 4 having a liquid introduction needle 5 attached thereto is connected to the tip via a connection tube 6. As shown in FIG. 2, the bag body 2 includes an inner layer sheet 13 having a vinyl acetate content of 15 to 35% and an outer layer sheet 1 having a vinyl acetate content of 5 to 15% or less.
First sheet 10 consisting of 2 and vinyl acetate content 15-
The second sheet 11 is composed of a 35% single-layer sheet.

The first sheet 10 includes an inner layer sheet 13 and an outer layer sheet 12
The outer layer sheet 12 has a thickness of 50 μm or less, and the inner layer sheet 13 has a thickness of 250 to 500 μm. Second sheet 11
Are formed to a thickness of 250 to 550 μ.

Since the transparency of the ethylene-vinyl acetate copolymer decreases as the content of vinyl acetate decreases, the outer layer sheet 12 is preferably formed thinner as the content of vinyl acetate decreases.

Further, the ethylene-vinyl acetate copolymer, when the content of vinyl acetate exceeds a certain amount, the water vapor permeability decreases, so when used in a high calorie infusion bag or the like that requires gas buyer property, the above-mentioned sheet Nos. 10 and 11 having a low vinyl acetate content are used, and on the other hand, when they are used in a cell culture bag or the like that requires gas permeability, it is preferable to use a vinyl acetate content having a high vinyl acetate content.

Both surfaces of the first sheet 10 (surfaces of the outer layer sheet 12 and the inner layer sheet 13) are formed to be smooth. Second
The outer surface of the sheet 11 is formed to be smooth, and the inner surface facing the first sheet 10 is formed with ribs in a mode described later in order to prevent blocking with the first sheet 10.

The first sheet 10 includes an outer layer sheet 12 and an inner layer sheet 13
After being laminated by a predetermined method, they are wound into a roll and installed in a device for welding the second sheet 11 in a bag shape. The outer layer sheet 12 has a vinyl acetate content of 5 to 1
Since it is adjusted to 5%, it does not cause blocking with each other even when wound in a roll shape, and when it is welded to the first sheet 10 and a bag shape, it smoothly changes from a roll shape to a sheet shape. It can be opened. The rib formed on the inner surface of the second sheet 11 can be formed in the following manner.

FIG. 3 shows a gentle rib 21 having a height H of 40 to 60 μm.
Is formed, and the pitch W of the ribs 21 is formed to be 100 to 200 μ. The ribs 21 may be formed regularly or irregularly.

FIG. 4 shows an embodiment of the rib 23 formed in conjunction with the longitudinal, lateral or diagonal direction of the sheet 22. The height H and the pitch W of the rib 23 are formed similarly to the rib 21 described above.

FIG. 5 shows ribs 24 and 25 having different shapes and heights.
It is the example which formed. The rib 24 is a cube and has a height h and a width w. The rib 25 is hemispherical and has a height H and a width W.

Specific shapes of the ribs formed on the inner surface of the sheet constituting the flexible bag of the present invention include a rectangular parallelepiped, a right-angled prism, an inclined prism, a right-angled frustum, a right circular cylinder, in addition to the cube and the hemisphere described above. It can be formed by combining at least two or more kinds selected from a right circular truncated cone, a spherical band having a specific shape, and an irregular shape.

When forming three or more types of protrusions, the height of the protrusions is
It is sufficient that at least two ribs have different heights.

Further, the following embodiment is conceivable as a mode in which two or more kinds of ribs are arranged on the surface of the sheet.

(1) As shown in FIG. 6, a mode in which the respective protrusions forming two or more types of protrusions are arranged in a concentrated manner at a specific position without being mixed.

(2) A mode in which two or more kinds of ribs are formed at positions where blocking of the sheet is likely to occur and one kind of rib is formed in the other portions as shown in FIG.

(3) As shown in FIG. 8, a mode in which the ribs forming two or more kinds of ribs are mixedly formed over the entire surface of the sheet (excluding the fused portion of the sheet).

(4) In the above (1) to (3), the ribs forming two or more types of ribs are regularly or irregularly formed.

(5) As shown in FIG. 9, in the above (2) to (3), two or more types of ribs are regularly or irregularly formed in each of two or more types of blocks.

(6) In the above (1) to (5), two or more types of ribs are formed on the inner surface of the sheet.

The maximum height H of the above-mentioned two types of ribs is preferably 200 μ or less, and if the maximum height H is 200 μ or more, the appearance of the flexible bag, particularly the transparency, may be impaired and the internal liquid component may be damaged.

On the other hand, the minimum height h is preferably 5 μ or more. If it is 5 μm or less, the blocking preventing effect is not sufficient.

The maximum width W is preferably 500 μm or less, and when it is 500 μm or more, the contact area between the protrusions becomes large and blocking easily occurs.

The minimum width w is preferably 20 μm or more. If it is 20 μm or less, the effect on blocking is reduced and processing becomes difficult.

[Effects of the Invention] As described above, the flexible bag of the present invention has an improved transparency of the bag body and makes it easier to see the inside, so that it is easy to observe the remaining amount of the drug solution and the cell proliferation level. .

[Brief description of drawings]

FIG. 1 is a schematic view of a flexible bag, and FIG. 2 is A- of FIG.
Sectional views A and FIGS. 3 to 9 show examples of ribs formed on the surface of the sheet. In the figure, 1 is a flexible bag, 2 is a bag body, 10 is a first sheet, 11 is a second sheet, 12 is an outer layer, 13 is an inner layer,
Reference numerals 21, 23, 24 and 25 denote ribs.

Claims (1)

[Scope of utility model registration request] 1. A flexible bag comprising a flexible bag body and a liquid transfer tube attached to the body, the bag body comprising an ethylene-vinyl acetate copolymer, the bag body comprising: The first sheet constituting the vinyl acetate content is 5 to 15%
Of the outer layer sheet and the inner layer sheet having a vinyl acetate content of 15 to 35%, the outer layer sheet and the inner layer sheet having smooth surfaces, and the second sheet constituting the bag body has a vinyl acetate content of 15%. A flexible bag comprising a single-layer sheet of ˜35% and ribs formed on the inner surface side of the second sheet.