JPH05320035A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a cosmetic having excellent skin-beautifying effect, effective in preventing chapped skin and wrinkles, smoothing the skin and keeping fresh skin, having high safety and producible from an easily available raw material. CONSTITUTION:Saraka indica which is a plant of the family Leguminosae called as MUKOUJU and known as a herb drug is extracted with a solvent and the extract is compounded in an amount of 0.00001-5wt.%, preferably 0.0001-2wt.% (in terms of dry material) to a cosmetic such as lotion, cream, milky lotion or pack to obtain a cosmetic having the above effects. The solvent used in the extraction of Saraka indica is a lower alcohol (e.g. methanol or ethanol), a polyhydric alcohol (e.g. glycerol, propylene glycol or 1,3-butylene glycol), a hydrophilic organic solvent (e.g. acetone), water or a mixture of two or more kinds of the above solvents, especially preferably ethanol, water or their mixture.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect, smoothing the skin and keeping youthful skin.

[0002]

[Prior Art] Saraka indica
It is a plant of the family blister, called Muyuju, and it is a sacred tree of Hinduism. Muyuju is an evergreen tree that is usually about 4-8m long and rarely exceeds 20m. The bark is thick, grayish reddish brown, and leaves are pinnate compound. It is distributed in the central to eastern foothills of the Himalayas, eastern Bengal, western Indian Peninsula, and northern India, and is cultivated in some areas. This plant is used as a medicine, leaves are used as a medicine for abdominal pain, bark is used as a hemostatic agent for the treatment of excessive menstruation, and it is also used as a raw material for the treatment of hemorrhoids after decoction. Absent.

[0003]

DISCLOSURE OF THE INVENTION The object of the present invention is to have a high whitening effect, to make the skin smooth, to keep youthful skin,
Moreover, it is to provide cosmetic raw materials that are highly safe and easily available.

[0004]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have conducted earnest research on plant extracts that have been used internally as crude drugs for a long time and have been confirmed to be safe. The present invention was completed by applying the extract of Salaca indica to the skin and finding that it has excellent effects such as a whitening effect.

That is, the present invention is a cosmetic product containing a solvent extract of Saraka indica.
Saraka indica has been used for a long time, and water or ethanol extract has been used, and its safety has been sufficiently confirmed.

The solvent for extracting this salaca indica is ethanol, a lower alcohol such as ethanol, a polyhydric alcohol such as glycerin, propylene glycol, 1,3 butylene glycol, a hydrophilic organic solvent such as acetone and water, or two kinds of these. Extract using the above mixed solvent. However, ethanol, water, or a mixture thereof is most suitable for extracting cosmetic raw materials. The extraction time is selected according to the cutting method, temperature and stirring conditions of Saraca Indica.

To this substance, other cosmetic raw materials, for example, liquid oil such as suwaran and jojoba oil, solid oil such as beeswax and cetyl alcohol, various activators, moisturizers such as glycerin and 1,3 butylene glycol and various chemicals are added. Thus, cosmetics of various dosage forms can be prepared. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose. The amount of this extract compounded depends on the dosage form to be compounded, the purpose of the product, the presence or absence of a coexisting drug, the place of production and the type of Salaca indica, and the effect is different.
Amount of 00001 to 5% by weight, preferably 0.0001 to 2% by weight is suitable.

[0008]

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. First, a method for producing the solvent extract used in the examples will be described.

Production Example 1 Saraka Indica Bark 5
500 ml of methanol was added to 0 g, and the mixture was heated for 3 hours with a reflux condenser attached. After cooling, filtering, and concentration under reduced pressure,
Lyophilized.

Production Example 2 Saraka Indica Bark 5
To 0 g, 500 ml of 50% methanol was added and heated for 3 hours with a reflux condenser attached. After cooling, filtration, concentration under reduced pressure, and lyophilization.

(Production Example 3) Baraka 5 of Saraca Indica
To 0 g, 500 ml of purified water was added and heated at 80 ° C. for 3 hours. After cooling, filtration and freeze-drying were performed.

(Example 1) Lotion Extract of Production Example 1 1.0 Purified water 94.0 Glycerin 4.9 Methyl paraoxybenzoate 0.1

(Example 2) Cream A Squalane 20.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 B Purified water 54.9 Poly Oxyethylene (20E.0.) Sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 Glycerin 5.0 Methyl paraoxybenzoate 0.1 Extract of Production Example 2 2.0 For A, weigh each B, warm to 70 ° C, gradually add A to B with stirring, and then slowly add 30 with stirring.
Cooled to ° C.

Example 3 The extract of Production Example 2 of Example 2 was replaced with the extract of Production Example 3.

Comparative Example 1 The extract of Production Example 1 of Example 1 was replaced with purified water.

Comparative Example 2 The extract of Production Example 2 of Example 2 was replaced with purified water.

(Measurement of Tyrosinase Activity Inhibition Rate) (Test Method) Mcllvaln Buffer Solution 0.9
ml, 1.0 ml of 1.66 mM Tyrosine solution,
The extracted dried product of the above Production Example was dissolved in ethanol, water was added, and ethanol was removed by an evaporator,
Take 1.0 ml of a specified concentration aqueous solution of the sample specimen adjusted to 0.1% by weight (dry matter) / volume% in a screw vial and
It heated for 5 minutes or more in a 7 degreeC thermostat water tank. Add 0.1 ml of tyrosinase solution (manufactured by Sigma, derived from mushroom, 914 units / ml) and keep warm in a 37 ° C constant temperature water bath,
After 10 minutes the absorbance was measured at 475 nm. As a control
Pure water was added instead of the above sample solution, and the same measurement was performed. (Test formula) A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 The measurement results are shown in Table 1.

[0018]

[Table 1]

There is 21% oxygen in the atmosphere, without which no organisms (except anaerobic) can exist. However, oxygen becomes active oxygen under the influence of ultraviolet rays and enzymes. Active oxygen oxidizes fatty acids and produces peroxides.
It also oxidizes and damages the phospholipids of biological membranes in the body. Moreover, it is said that the generated peroxide and active oxygen damage DNA and accelerate aging. It also affects the mechanism of melanin production from tyrosine and is involved in skin darkening. Suppressing this active oxygen is one of the important factors required for the skin, in other words, for cosmetics. There are various methods for measuring the effect of suppressing active oxygen, but the following method was used this time. pH 7.8 50 mM potassium phosphate buffer (containing 1.3 mM DETAPAC) 133 ml 40 unit / ml Catalase above potassium phosphate buffer 5 ml 2 mM Nitroblue tetrazolium above potassium phosphate buffer 5 ml 1.8 mM xanthine above Potassium phosphate buffer 17 ml 160 ml Add 2.4 ml of the above mixture of reagents and 0.3 ml of sample,
A solution of xanthine oxinase (prepared with water as a sample in advance and adjusted with the above-mentioned potassium phosphate buffer so that the absorbance increases about 0.02 per minute during the experiment) was used.
Immediately after adding 3 ml, the absorbance (560 nm) is measured. (Measurement is performed for 2 minutes and linearity is confirmed) A: Change in absorbance per minute when the sample is water B: Change in absorbance per minute of sample Calculation formula Inhibition rate = (AB ) / A × 100 The results are shown in Table 2 in terms of the concentration at which 50% active oxygen production is inhibited.

[0020]

[Table 2]

(Usage Test) Faces of five women were divided into right and left, one of which was used as an example and the other of which was used as a comparative example once or more daily, and a questionnaire was conducted after 3 months. In addition, 10 people were divided into 2 groups and experimented using the samples in Table 3 below.

[0022]

[Table 3]

The judgment criteria are as follows, and the results of the questionnaire are summarized in Table 4 below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is good −1 Comparative example is good −2 Comparative example Is very good -3

[0024]

[Table 4]

[0025]

EFFECTS OF THE INVENTION The extract of Salaca indica is useful for whitening, preventing rough skin and preventing wrinkles, and is the most suitable raw material for cosmetics.

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[Procedure amendment]

[Submission date] December 10, 1991

[Procedure Amendment 1]

[Document name to be amended] Statement

[Correction target item name] 0006

[Correction method] Change

[Correction content]

The solvent for extracting this saraca indica is
Extraction is performed using a lower alcohol such as methanol and ethanol, a polyhydric alcohol such as glycerin, propylene glycol, and 1,3-butylene glycol, a hydrophilic organic solvent such as acetone and water, or a mixed solvent of two or more of these. However, ethanol, water, or a mixture thereof is most suitable for extracting cosmetic raw materials. The extraction time is selected according to the cutting method, temperature and stirring conditions of Saraca Indica.

[Procedure Amendment 2]

[Document name to be amended] Statement

[Correction target item name] 0018

[Correction method] Change

[Correction content]

[0018]

[Table 1]

[Procedure 3]

[Document name to be amended] Statement

[Correction target item name] 0020

[Correction method] Change

[Correction content]

[0020]

[Table 2]

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakamura Masami 6-32 Ikegami Town, Toba City, Mie Prefecture (72) Inventor Koori Takamatsu 1207-3, Kakihana Town, Matsuzaka City, Mie Prefecture

Claims (1)

[Claims] 1. The Saraka indica
Cosmetics containing the solvent extract of.