JPH049424B2 - - Google Patents

Description

[Detailed description of the invention]

[Industrial Application Field] The present invention relates to a hollow fiber membrane oxygenator for removing carbon dioxide from blood and adding oxygen in extracorporeal blood circulation. [Prior Art] Conventionally, artificial lungs are broadly classified into bubble type and membrane type. Membrane oxygenators such as stacked, coil, and hollow fiber oxygenators are superior to bubble oxygenators in that they cause less blood damage such as hemolysis, protein denaturation, and blood coagulation, and have become quite popular in recent years. . Furthermore, among membrane oxygenators, those using a porous gas exchange membrane are widely used because they have a high gas exchange ability. As a membrane oxygenator using a porous gas exchange membrane, for example,
54-160098, JP-A-57-136456, etc. A conventional membrane oxygenator is shown in FIG. In this artificial lung, blood flows inside the hollow fiber membrane 60, and gas flows between the outside of the hollow fiber membrane 60 and the housing 62. In order to prevent gas channeling, the diameter of the hollow fiber membrane bundles is increased at the partition wall where the hollow fiber membrane bundles are bonded at both ends of the oxygenator housing to increase the gap between the hollow fiber membranes. In the middle of the direction, the outer diameter of the hollow fiber membrane bundle is made small so that gas can spread throughout the hollow fiber membranes. [Problems to be Solved by the Invention] However, in the oxygenator shown in FIG. 13, if the hollow fiber membranes in the hollow fiber membrane bundle are not sufficiently dispersed, or if the housing has a narrow inner diameter in order to make the oxygenator smaller, When a hollow fiber membrane bundle is housed in a hollow fiber membrane and the filling rate of the hollow fiber membrane is high, the oxygen-containing gas flowing in from the gas inlet 64 does not come into contact with the entire hollow fiber membrane, and the oxygen-containing gas does not reach the center of the hollow fiber membrane bundle. Since it is difficult for the contained gas to flow in, there is a problem in that the oxygen-containing gas flows along the periphery of the hollow fiber membrane bundle, and the hollow fiber membranes in the center do not contribute to gas exchange. In addition, in the oxygenator described above, in order to ensure that the oxygen-containing gas sufficiently flows to the inside of the hollow fiber membrane bundle, the filling rate of the hollow fiber membranes at the end of the housing must be made quite low. For this purpose, a housing with a large inner diameter must be used, resulting in the problem that the entire oxygenator becomes large and the priming volume of blood increases. Therefore, the applicant proposed a hollow fiber membrane type artificial membrane with high gas exchange ability, which allows the oxygen-containing gas flowing in from the gas inlet to flow into the interior of the hollow fiber membrane bundle without using a large housing. The lungs include a housing, a hollow fiber membrane bundle consisting of a large number of porous hollow fiber membranes inserted into the housing, and a partition wall that fluid-tightly fixes both ends of the hollow fiber membrane bundle to both ends of the housing. , a gas inlet and a gas outlet that are provided near the end of the housing and communicate with a space formed by the outer surface of the hollow fiber membrane, the inner surface of the housing, and the partition wall; In a hollow fiber membrane oxygenator having a blood inlet and a blood outlet, a hollow fiber membrane is provided with a gas guiding member extending inward of the hollow fiber membrane bundle at least in the vicinity of the gas inlet. We are proposing a type of artificial lung. With the above oxygenator, oxygen-containing gas flowing from the gas inlet can flow into the hollow fiber membrane bundle without using a large housing, and a hollow fiber membrane oxygenator with high gas exchange capacity can be created. However, since a gas guide member is housed inside the oxygenator, if the end of the gas guide member is embedded in the partition wall, a pinhole may occur in the partition wall. is likely to occur,
There was a risk of blood leaking. Therefore, the present invention enables the oxygen-containing gas flowing in from the gas inlet to flow into the interior of the hollow fiber membrane bundle without using a large housing, has high gas exchange ability, and has a gas guiding member. To provide a hollow fiber membrane type oxygenator which does not generate pinholes in the partition wall even when the membrane is housed, and there is no risk of blood leakage. [Means for Solving the Problems] The object of the present invention described above is achieved by a housing, a hollow fiber membrane bundle consisting of a large number of porous hollow fiber membranes inserted into the housing, and the hollow fiber membranes. partition walls that liquid-tightly fix both ends of the bundle to both ends of the housing; and a space provided near both ends of the housing and formed by the outer surface of the hollow fiber membrane, the inner surface of the housing, and the partition wall. A gas inlet and a gas outlet that communicate with each other, a blood inlet and a blood outlet that are respectively attached to both ends of the housing, and communicate with the gas inlet and the hollow fiber membrane bundle and the inner surface of the housing. has an annular portion that does not contact, and further includes at least
A gas guiding member is provided in the hollow fiber membrane bundle in the portion where the annular portion is provided, and further, an end portion of the gas guiding member extends inward from the peripheral edge of the hollow fiber membrane bundle. This is a hollow fiber membrane oxygenator that is installed so as not to reach the outer end surface of the partition wall on the gas inlet side. Furthermore, it is preferable that the end portion of the gas guide member is housed so as not to reach the outer end surface of the partition wall on the gas inlet side, and is held by the partition wall. The hollow fiber membrane has an inner diameter of 100~
1000μm, wall thickness 5-80μm, and diameter 100Å-5μm
It is preferable that the material has micropores of . The gas guiding member is, for example, planar. Further, the gas guide member has, for example, a curved surface shape. Furthermore, the gas guiding member
Preferably, the thickness is 30 to 400 μm. Furthermore, it is preferable that the gas guide member has a network structure. Furthermore, it is preferable that the gas guiding member has a mesh size of 20 to 400 meshes. The gas guide member extends, for example, from the inside of the peripheral edge of the hollow fiber membrane bundle to the inside of another peripheral edge through approximately the center of the hollow fiber membrane bundle. Furthermore, a plurality of gas guide members may be provided. Further, the gas guiding member is, for example, a plurality of gas guiding members extending from inside the peripheral portion of the hollow fiber membrane bundle toward the center of the hollow fiber membrane bundle. Further, the plurality of gas guiding members are spaced apart from each other at approximately equal intervals, for example, and extend from inside the peripheral portion toward approximately the center of the hollow fiber membrane bundle. Further, in the hollow fiber membrane oxygenator, the hollow fiber membrane bundle and the inner surface of the housing are continuous with an annular portion that does not come into contact with each other, and
It is preferable that the outer periphery of the hollow fiber membrane bundle and the inner surface of the housing have an annular portion in contact with each other. Furthermore, the gas guiding member extends beyond a portion of the hollow fiber membrane bundle where an annular portion is provided where the hollow fiber membrane bundle and the inner surface of the housing do not come into contact with each other, and extends between the outer periphery of the hollow fiber membrane bundle and the inner surface of the housing. It is preferable that the housing is provided so as to reach an annular portion in contact with the housing, and the terminal end is provided so as not to reach an intermediate portion of the housing. The membrane oxygenator of the present invention will be explained using examples shown in the drawings. FIG. 1 is a partial sectional view of a hollow fiber membrane oxygenator according to an embodiment of the present invention, and FIG. 2 shows a gas inlet 13 in the hollow fiber membrane oxygenator shown in FIG. It is a cut sectional view. The hollow fiber membrane oxygenator 1 of the present invention has a housing 6
, a hollow fiber membrane bundle 4 consisting of a large number of porous hollow fiber membranes inserted into the housing 6 , and partition walls 10 and 11 that fix both ends of the hollow fiber membrane bundle 4 to both ends of the housing 6 in a fluid-tight manner. , a gas inlet 13 and a gas outlet 14 that are provided near both ends of the housing 6 and communicate with the space formed by the outer surface of the hollow fiber membrane, the inner surface of the housing 6, and the partition wall, and Blood inlet 29 and blood outlet 28 and gas inlet 13 are respectively attached.
The hollow fiber membrane bundle 4 has an annular portion 40 that communicates with the hollow fiber membrane bundle 4 and the inner surface of the housing 6 and does not come into contact with the inner surface of the housing 6. It has a gas guide member 3 extending inward from the peripheral edge of the membrane bundle 4, and furthermore, the end of the gas guide member 3 is provided so as not to reach the outer end surface 35 of the partition wall 10 on the gas inlet 13 side. There is. The hollow fiber membrane 2 used in the oxygenator 1 of the present invention is
It is a porous membrane and has many micropores penetrating the hollow fiber membrane wall. As a gas exchange membrane, the wall thickness is 5.
~80μm, preferably 10~60μm, porosity 20~80
%, preferably 30-60%, and the fine pore size is 0.01
~5μm, preferably about 0.01~1μm, inner diameter 100~
A thickness of 1000 μm, preferably 100 to 300 μm is suitably used. The material of the hollow fiber membrane 2 is polypropylene,
Hydrophobic polymers such as polyethylene, polytetrafluoroethylene, polysulfone, polyacrylonitrile, and cellulose acetate can be used, preferably hydrophobic polymers, particularly preferably polyolefin resins, and more preferably polypropylene. Polypropylene in which fine pores have been formed by a stretching method or a solid-liquid phase separation method is desirable. As a hollow fiber membrane type oxygenator 1, FIG. 1 shows an assembled state of a hollow fiber membrane type oxygenator which is one embodiment thereof. This hollow fiber membrane type oxygenator 1 includes a cylindrical housing 6 and 10,000 to 70,000 hollow fiber membranes 2 spread throughout the housing 6. This hollow fiber membrane 2 has a large number of micropores in its wall that form a gas flow path that communicates the inside and outside of the hollow fiber membrane, and both ends of the hollow fiber membrane 2 are connected to each other. Partition wall 1 with the opening not blocked
0 and 11, it is fixed to the end of the housing 6 in a liquid-tight manner. The partition walls 10 and 11 allow the inside of the housing 6 to be divided into an oxygen chamber 12 formed by the outer wall of the hollow fiber membrane, the inner wall of the housing 6, and the partition walls 10 and 11, and a blood circulation space formed inside the hollow fiber membrane. It is divided into The housing 6 is provided with an inlet 13 for a gas containing oxygen near one end, and an outlet 14 near the other end. Furthermore, a flow path forming member 19 having a blood inlet 29 and an annular protrusion 25 is fixed to the outside of the partition 11 with a screw ring 23, and a blood outlet 28 and an annular protrusion are attached to the outside of the partition 10. A flow path forming member 18 having a diameter of 24 is fixed by a screw ring 22 . The convex portions 24 and 25 of the flow path forming members 18 and 19 are in contact with the partition walls 10 and 11,
On the outer periphery of the convex portions 24 and 25, at least two
A sealant is filled from one of the holes 30, 31, 32, 33, and the flow path forming members 18, 19 are fixed to the partition walls 10, 11 in a liquid-tight manner. In the above explanation, the threaded ring is used, but the flow path forming member may be directly fused to the housing using high frequency waves, ultrasonic waves, etc., or may be bonded using an adhesive or the like. You may. Further, instead of the above sealant, an O-ring made of silicone rubber or the like may be used to liquid-tightly seal the flow path forming member to the partition wall. In the hollow fiber membrane bundle 4 near the gas inlet 13 of the oxygenator 1, a gas guide member 3 extending at least toward the inside of the hollow fiber membrane bundle 4 from near the periphery of the hollow fiber membrane bundle 4 is installed. The end portion 36 of the partition wall 10 is housed so as not to reach the outer end surface 35 of the partition wall 10 on the gas inlet 13 side. In the embodiment shown in FIG.
The gas guide member 3 has a planar shape, and is formed by four gas guide members extending from the peripheral edge of the hollow fiber membrane bundle 4 to the vicinity of the center of the hollow fiber membrane bundle 4 at approximately equal intervals. A simplified diagram of the installed state of the gas guide member 3 is shown in FIG. The gas guiding member 3 formed by four gas guiding members has a portion in the center of the hollow fiber membrane bundle 4 that does not come into contact with each other. By doing so, the gas flows only through the gas guiding member, and it is preferable to prevent the gas from diffusing around the hollow fiber membrane located at a position away from the gas guiding member. Further, the number of gas guiding members is not limited to four, and may be one, or even two or more. More preferably, three or more membranes are provided so as to extend from the periphery of the hollow fiber membrane bundle 4 to near the center of the hollow fiber membrane bundle 4 with approximately equal spacing. Further, the shape of the gas guiding member is not limited to a planar shape, but may be a curved shape. The gas guide member 3 may be a plate-shaped member made of synthetic resin such as polyolefin (for example, polyethylene, polypropylene), polyester, or polyvinyl chloride, metal such as iron or stainless steel, or ceramic, but is preferably has a network structure with low gas inflow resistance. Examples of mesh structures include mesh or nonwoven fabric using synthetic fibers such as polyester fibers, polyamide fibers, and polypropylene fibers, metal wires such as stainless steel, carbon fibers, glass fibers, porous ceramics, etc., and the size of the mesh is 20 to 400 meshes, preferably 20 to 100 meshes, and the thickness is 30 to 400 μm, preferably 150 to 400 μm.
300 μm, and the length of the hollow fiber membrane bundle 4 in the axial direction is 10 to 80%, preferably 20 to 40%, of the effective length of the hollow fiber membrane. As shown in FIGS. 1 and 2, the oxygenator 1 has an annular portion 40 in which the outer periphery of the hollow fiber membrane bundle 4 does not come into contact with the housing 6, and the gas inlet is provided through this annular portion 40. is connected to. Furthermore, the oxygenator 1 has an annular portion in which the outer periphery of the hollow fiber membrane bundle 4 is continuous with an annular portion 40 that does not come into contact with the housing 6, and in which the outer periphery of the hollow fiber membrane bundle 4 and the inner surface of the housing are in contact. ing. The gas guiding member 3 is shown in FIGS. 1 and 2.
As shown in the figure, the annular portion 40 that does not contact the hollow fiber membrane bundle 4 with the inner surface of the housing 6 is provided so as to exist at least in a portion of the hollow fiber membrane bundle surrounded by the annular portion 40 . In this way, the gas guiding member 3
Since the hollow fiber membrane bundle 4 and the inner surface of the housing 6 are not in contact with each other, the annular portion is provided in the surrounding portion of the hollow fiber membrane bundle, so that the gas flowing in from the gas inlet 3 flows into the annular portion 40, in other words, inside the annular portion. It flows into the space and is distributed throughout the annular portion 40 . Therefore, the inflowing gas reliably contacts the peripheral edge of the hollow fiber membrane bundle in the portion surrounded by the annular portion 40 where the hollow fiber membrane bundle 4 and the inner surface of the housing 6 do not come into contact. Furthermore, since the gas guiding member 3 is provided within the hollow fiber membrane bundle in the portion surrounded by the annular portion 40, the gas easily comes into contact with the gas guiding member 3, and gas is reliably introduced into the hollow fiber membrane bundle. Induce. In the artificial lung shown in FIG. 1, the gas guiding member 3 is provided only near the gas inlet 13. Specifically, as shown in FIG. 1, one end of the gas guiding member 3 is held inside the partition wall 10, and the other end is held within the hollow fiber membrane bundle 4.
The annular portion 4 does not come into contact with the inner surface of the housing 6.
0 and extends to the annular portion where the outer periphery of the hollow fiber membrane bundle 4 contacts the inner surface of the housing, and the other end is located at the restraining portion of the hollow fiber membrane bundle 4 which is the middle portion of the housing 6. It is designed to prevent this from happening. Providing the gas guide member as described above is preferable because it can reliably prevent the formation of a gas short-circuit path due to the gas guide member 3;
The gas guiding member 3 may extend to a restraining portion of the hollow fiber membrane bundle 4, which is an intermediate portion of the housing 6. Furthermore, it may extend to the vicinity of the gas outlet 14. As in the embodiment shown in FIG. It is stored in. By doing this, the end portion 36 of the gas guiding member 3 is not present near the outer end surface 35 of the partition wall 10, and only the hollow fiber membrane is present, so that the hollow fiber membrane is not alienated by the gas guiding member. The potting agent used to form the partition walls that fix the hollow fiber membranes to the housing can be dispersed uniformly, and the potting agent used to form the partition walls that fix the hollow fiber membranes to the housing can be reliably flowed between the hollow fiber membranes of the hollow fiber membrane bundle, and the potting agent used to form the partition walls that fix the hollow fiber membranes to the housing can be reliably flowed between the hollow fiber membranes of the hollow fiber membrane bundle. The occurrence of pinholes can be prevented. Furthermore, as in the embodiment shown in FIG. It is preferable that the end portion 36 is embedded and held inside the partition wall 10. As a method for holding the end portion 36 of the gas guiding member 3 by the partition wall 10, a method for holding the end portion 36 of the gas guiding member 3 by the partition wall 10 includes
The gas guiding member 3 housed in such a manner that the end thereof is closer to the inside of the hollow fiber membrane than the end of the hollow fiber membrane is inserted into the housing, and the hollow fiber membranes are dispersed at the end of the hollow fiber membrane bundle. After that, the end 36 of the gas guide member 3 is fixed to the end of the housing 6 together with the hollow fiber membrane bundle 4 with a potting agent (for example, polyurethane), and this potting agent is applied to the part where the gas guide member 3 is not present. This can be done by slicing to form the partition walls 10. Further, the gas guiding member may be inserted into the hollow fiber membrane bundle after the hollow fiber membrane bundle is inserted into the housing. By embedding the end portion of the gas guide member 3 within the partition wall 10 in this manner, movement of the gas guide member 3 can be prevented. In the above description, the case where the end portion of the gas guiding member 3 is held by the partition wall 10 has been described.
However, the gas guide member 3 may not be held by the partition wall 10. in this case,
The end of the gas guiding member 3 will be located within the gas chamber formed by the housing and the outer wall of the hollow fiber membrane. By providing the gas guide member 3, even if the filling rate of the hollow fiber membrane in the area where the gas guide member 3 is provided is 50% or more, the gas flows almost to the center of the hollow fiber membrane bundle 4. can improve gas exchange efficiency. The filling rate of the hollow fiber membrane is as follows: When the inner diameter of the housing 6 is R, the outer diameter of the hollow fiber membrane is r, and the number of hollow fiber membranes is n, the filling rate = total cross-sectional area of the hollow fiber membrane/housing The internal cross-sectional area of is x 100, and it is determined by the following formula: Filling rate = n・1/4πr ² /1/4R ² x 100. In the above description, an example is given in which four planar plates are used as the gas guiding member 3, but the present invention is not limited to this, and various other configurations are possible. For example, embodiments having other forms of the gas guide member 3 will be described with reference to FIGS. 4 to 11. 4 to 11 are cross-sectional views of the hollow fiber membrane oxygenator cut near the gas inlet 13. Note that the hollow fiber membrane is omitted. The gas guiding member 3 shown in FIG. ) and extends inside the other periphery. It is provided so as to divide the hollow fiber membrane bundle 4 into two. The material etc. of the gas guiding member are the same as those described above. In the one shown in FIG. 5, the gas guiding member 3 is composed of three gas guiding members extending from inside the peripheral edge of the hollow fiber membrane bundle 4 toward the center of the hollow fiber membrane bundle 4 (towards the center of the housing 6). be. Further, the three gas guide members extend approximately toward the center of the hollow fiber membrane bundle 4 from the inside of the peripheral portion spaced apart at approximately equal intervals. In the one shown in FIG. 6, the gas guiding member 3 is composed of eight planar gas guiding members extending from the inside of the peripheral edge of the hollow fiber membrane bundle 4 toward the center of the hollow fiber membrane bundle 4 (towards the center of the housing 6). It is what it is. Further, the eight gas guide members extend approximately toward the center of the hollow fiber membrane bundle 4 from inside the peripheral edge portions spaced at approximately equal intervals. In the one shown in FIG.
Each gas guide member extends from the inside of the periphery at approximately equal intervals toward the inside of the hollow fiber membrane bundle 4 and toward the ends of the adjacent gas guide members. It is something that exists. In the gas guide member 3 shown in FIG. 8, the gas guide member 3 has three planar shapes, and one gas guide member connects the hollow fiber membrane bundle 4 from the inside of the peripheral edge of the hollow fiber membrane bundle 4. The other two gas guiding members are located at a position slightly apart from the gas guiding member passing through the center of the hollow fiber membrane bundle 4. are placed in parallel. In the one shown in FIG. 9, the gas guiding member 3 is composed of four curved gas guiding members extending from the inside of the peripheral edge of the hollow fiber membrane bundle 4 toward the center of the hollow fiber membrane bundle 4 (towards the center of the housing 6). It is what it is. Further, the four gas guiding members extend approximately toward the center of the hollow fiber membrane bundle 4 from inside the peripheral edge portions spaced at approximately equal intervals. In the one shown in FIG. 10, the gas guiding member 3 is
Consisting of two gas guiding members each having a curved surface shape extending from the inside of the periphery of the hollow fiber membrane bundle 4 toward the center of the hollow fiber membrane bundle 4 (toward the center of the housing 6) and further extending toward the periphery of the hollow fiber membrane bundle 4. It is. Also, 2
The gas guide members extend from the inside of the peripheral edge portions spaced at approximately equal intervals toward the center of the hollow fiber membrane bundle 4 and further extend to the peripheral edge portions of the hollow fiber membrane bundle 4 spaced at approximately equal intervals. FIG. 13 shows a simplified diagram of the installed state of the gas guiding member 3 shown in FIG. 10. In the one shown in FIG. 11, the gas guiding member 3 is
One gas guiding member is spirally provided from inside the peripheral edge of the hollow fiber membrane bundle 4 to the center of the hollow fiber membrane bundle 4 (the center of the housing 6). Next, examples of the present invention will be described. Example 1 A polycarbonate housing with a length of 170 mm, an inner diameter of 124 mm at the end, and an inner diameter of 92 mm at the middle, an inner diameter of 200 μm,
Inside a hollow fiber membrane bundle consisting of approximately 62,000 polypropylene hollow fiber membranes with a wall thickness of 50 μm, a porosity of 35%, an average pore diameter of 600 Å measured by mercury intrusion method, and a length of approximately 217 mm.
A gas guiding member made of polyester having a planar shape as shown in Figures 2 and 3 and having a network structure of 70 meshes (the length in the center direction of the hollow fiber membrane bundle is
mm, the length of the hollow fiber membrane bundle in the axial direction is 50 mm) is 4
extending from the inside of the peripheral edge of the hollow fiber membrane bundle approximately toward the center of the hollow fiber membrane bundle, spaced apart from each other at approximately equal intervals;
and insert the gas guide member so that the end of the gas guiding member is about 20 mm closer to the center of the hollow fiber membrane bundle than the end of the hollow fiber membrane bundle,
The hollow fiber membranes are dispersed at the ends of the hollow fiber membrane bundle, and a container filled with a sealant is fitted onto the end of the hollow fiber membrane bundle.
and the container was secured to the end of the housing. Furthermore, a potting agent is injected from the gas inlet of the housing to fix the hollow fiber membrane bundle and the gas guiding member to the housing, and after removing the container, the potting agent is sliced in the part where the gas guiding member is not present. , a partition wall was formed, and the partition wall on the opposite side, which did not have a gas guide member, was formed in the same manner, and a hollow fiber membrane oxygenator having the structure shown in FIG. 1 was created. Effective length in the axial direction of the hollow fiber membrane bundle of the gas guiding member (length of the part not embedded in the partition wall)
was approximately 40 mm. The effective length of the hollow fiber membrane (the length of the portion not embedded in the partition wall) was approximately 140 mm. Additionally, the membrane area of this oxygenator is approximately 5.4 m ² . The filling rate of the hollow fiber membrane near the gas inlet of this oxygenator was 50%. Example 2 A polycarbonate housing with a length of 170 mm, an inner diameter of 124 mm at the end, and an inner diameter of 92 mm at the middle, an inner diameter of 200 μm,
Inside a hollow fiber membrane bundle consisting of approximately 62,000 polypropylene hollow fiber membranes with a wall thickness of 50 μm, a porosity of 35%, an average pore diameter of 600 Å measured by mercury intrusion method, and a length of approximately 217 mm.
A gas guide member (the length in the direction of the center of the hollow fiber membrane bundle) has a polyester network structure of 70 meshes with a curved surface shape as shown in Figures 10 and 12.
30 mm, and the length in the axial direction of the hollow fiber membrane bundle is 50 mm), so that it extends from inside the peripheral edge of the hollow fiber membrane bundle toward the center of the hollow fiber membrane bundle, and at the end of the hollow fiber membrane bundle. Insert the gas guiding member so that the end of the hollow fiber membrane bundle is approximately 20 mm toward the center of the hollow fiber membrane bundle, disperse the hollow fiber membranes at the ends of the hollow fiber membrane bundle, and seal the ends of the hollow fiber membrane bundle. A container filled with the agent was fitted and secured to the end of the housing. Furthermore, a potting agent is injected from the gas inlet of the housing to fix the hollow fiber membrane bundle and the gas guide member to the housing, and after removing the container, the potting agent is sliced in the part where the gas guide member is not present. , a partition wall was formed, and a partition wall on the opposite side that did not have a gas guide member was formed in the same manner to create a hollow fiber membrane oxygenator of the present invention. The effective length in the axial direction of the hollow fiber membrane bundle of the gas guiding member (the length of the portion not embedded in the partition wall) was approximately 40 mm. The effective length of the hollow fiber membrane (the length of the part not embedded in the partition wall) is:
It was about 140mm. Additionally, the membrane area of this oxygenator is approximately 5.4 m ² . The filling rate of the hollow fiber membrane near the gas inlet of this oxygenator was 50%. Comparative example 1 A polycarbonate housing with a length of 170 mm, an inner diameter of 124 mm at the end, and an inner diameter of 92 mm at the middle, an inner diameter of 200 μm,
It consists of approximately 62,000 polypropylene hollow fiber membranes with a wall thickness of 50 μm, a porosity of 35%, an average pore diameter of 600 Å measured by mercury intrusion method, and a length of approximately 217 mm.The outer diameter of the hollow fiber membrane bundle near the gas inlet is A hollow fiber membrane oxygenator having a membrane area of about 5.4 m ² as shown in FIG. 13 was prepared by housing a hollow fiber membrane bundle of about 100 mm in a housing. The effective length of the hollow fiber membrane (the length of the portion not embedded in the partition wall) was approximately 140 mm. The filling rate of the hollow fiber membrane near the gas inlet of this oxygenator was 50%. [Experiment 1] Blood gas exchange capacity was measured using the artificial lungs of Examples 1 and 2 and Comparative Example. The measurement was performed using fresh heparinized bovine blood from the blood inlet of the oxygenator (the hematocrit value was adjusted to 35% with physiological saline).
%, hemoglobin concentration 12 ± 1 g/dl, base excess 0 ± 2 mEq/, oxygen saturation 65 ±
5%, carbon dioxide partial pressure 45±5mmHg, temperature 37±2℃)
is flowed at a flow rate of 5.4/min in a single pass, and pure oxygen is flowed at a flow rate of 5.4/m from the gas inlet.
Blood flow at the blood inlet and blood outlet of the oxygenator
PH, partial pressure of carbon dioxide gas (pCO ₂ ), partial pressure of oxygen gas (pO ₂ ) was measured using a blood gas measuring device (manufactured by Radiometer,
ABL30), and the blood gas exchange rate (gas exchange capacity) was calculated from the results. The results are shown in Table 1.

[Table] Partial pressure - blood at outlet
CO ₂ partial pressure Carbon dioxide removal rate =

Claims (1)

[Claims] 1. A housing, a hollow fiber membrane bundle consisting of a large number of porous hollow fiber membranes inserted into the housing, and both ends of the hollow fiber membrane bundle being liquid-tightly attached to both ends of the housing. a partition wall to be fixed; a gas inlet and a gas outlet that are provided near both ends of the housing and communicate with a space formed by the outer surface of the hollow fiber membrane, the inner surface of the housing, and the partition;
The housing includes a blood inlet and a blood outlet respectively attached to both ends of the housing, and an annular portion that communicates with the gas inlet and does not allow the hollow fiber membrane bundle and the inner surface of the housing to come into contact with each other, ,
At least a gas guiding member is provided in the hollow fiber membrane bundle in the portion where the annular portion is provided, and further, an end portion of the gas guiding member extends inward from a peripheral edge of the hollow fiber membrane bundle. A hollow fiber membrane oxygenator, characterized in that the membrane is provided so as not to reach the outer end surface of the partition wall on the gas inlet side. 2. The hollow fiber membrane type according to claim 1, wherein the end of the gas guide member is housed so as not to reach the outer end surface of the partition wall on the gas inlet side and is held by the partition wall. Artificial lung. 3. Claim 1 or 2, wherein the hollow fiber membrane has an inner diameter of 100 to 1000 μm, a wall thickness of 5 to 80 μm, and has micropores of 100 Å to 5 μm in diameter.
The hollow fiber membrane oxygenator described in Section 1. 4. The hollow fiber membrane oxygenator according to any one of claims 1 to 3, wherein the gas guiding member is planar. 5. The hollow fiber membrane oxygenator according to any one of claims 1 to 4, wherein the gas guide member has a curved surface. 6. The hollow fiber membrane oxygenator according to any one of claims 1 to 5, wherein the gas guide member has a thickness of 30 to 400 μm. 7. The hollow fiber membrane oxygenator according to any one of claims 1 to 6, wherein the gas guiding member is a network structure. 8 The gas guiding member has a mesh size of 20 to
The hollow fiber membrane oxygenator according to claim 7, which has a mesh size of 400 mesh. 9. Claim 1, wherein the gas guiding member extends from inside the peripheral edge of the hollow fiber membrane bundle to the inside of another peripheral edge through approximately the center of the hollow fiber membrane bundle.
The hollow fiber membrane oxygenator according to any one of Items 1 to 8. 10. The hollow fiber membrane oxygenator according to any one of claims 1 to 9, wherein a plurality of gas guide members are provided. 11. Claim 1, wherein the gas guiding member is comprised of a plurality of gas guiding members extending from inside the peripheral edge of the hollow fiber membrane bundle toward the center of the hollow fiber membrane bundle.
The hollow fiber membrane oxygenator according to item 0. 12. The hollow fiber membrane oxygenator according to claim 11, wherein the plurality of gas guide members are spaced apart from each other at approximately equal intervals and extend from inside the peripheral portion toward the center of the hollow fiber membrane bundle. 13 The hollow fiber membrane oxygenator includes an annular portion that is continuous with an annular portion where the hollow fiber membrane bundle and the inner surface of the housing do not come into contact with each other, and an annular portion where the outer periphery of the hollow fiber membrane bundle and the inner surface of the housing come into contact. A hollow fiber membrane oxygenator according to any one of claims 1 to 12, comprising: 14. The gas guiding member extends beyond a portion of the hollow fiber membrane bundle provided with an annular portion where the hollow fiber membrane bundle and the inner surface of the housing do not come into contact with each other, and extends between the outer periphery of the hollow fiber membrane bundle and the inner surface of the housing. 14. The hollow fiber membrane oxygenator according to claim 13, wherein the hollow fiber membrane oxygenator is provided so as to reach an annular portion in contact with the housing, and a terminal end is provided so as not to reach an intermediate portion of the housing.