JPH0425922B2 - - Google Patents

Info

Publication number: JPH0425922B2
Authority: JP; Japan
Prior art keywords: melanin; suppressant; hydroxycinnamamide; pigmentation; skin
Prior art date: 1984-03-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP4684984A

Other languages

English (en)

Japanese (ja)

Other versions

JPS60190713A (ja

Inventor

Itsuro Mogi

Michio Kawai

Genji Imokawa

Koichi Nakamura

Naotake Takaishi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Kao Corp

Original Assignee

Kao Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-12

Filing date

1984-03-12

Publication date

1992-05-06

1984-03-12 Application filed by Kao Corp filed Critical Kao Corp

1984-03-12 Priority to JP4684984A priority Critical patent/JPS60190713A/ja

1984-04-18 Priority to GB08410127A priority patent/GB2141626B/en

1984-04-25 Priority to FR8406503A priority patent/FR2545355B1/fr

1984-04-25 Priority to DE19843415413 priority patent/DE3415413A1/de

1985-09-28 Publication of JPS60190713A publication Critical patent/JPS60190713A/ja

1985-12-24 Priority to US06/814,172 priority patent/US4978523A/en

1992-05-06 Publication of JPH0425922B2 publication Critical patent/JPH0425922B2/ja

Status Granted legal-status Critical Current

Links

DSMLJOHWFORNLY-UHFFFAOYSA-N 3-(4-hydroxyphenyl)prop-2-enamide Chemical class NC(=O)C=CC1=CC=C(O)C=C1 DSMLJOHWFORNLY-UHFFFAOYSA-N 0.000 claims description 6
125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
229940124200 Melanin inhibitor Drugs 0.000 claims description 2
125000003342 alkenyl group Chemical group 0.000 claims description 2
125000000217 alkyl group Chemical group 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 44
208000012641 Pigmentation disease Diseases 0.000 description 13
230000019612 pigmentation Effects 0.000 description 13
210000003491 skin Anatomy 0.000 description 13
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
-1 n- Butyl Chemical group 0.000 description 11
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
239000000203 mixture Substances 0.000 description 10
230000000694 effects Effects 0.000 description 8
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 6
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
239000006071 cream Substances 0.000 description 6
239000003205 fragrance Substances 0.000 description 6
PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
239000000126 substance Substances 0.000 description 6
208000003351 Melanosis Diseases 0.000 description 5
206010042496 Sunburn Diseases 0.000 description 5
235000011187 glycerol Nutrition 0.000 description 5
239000004615 ingredient Substances 0.000 description 5
239000008213 purified water Substances 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
VNDDFIQMUQVYDJ-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-n-methylprop-2-enamide Chemical compound CNC(=O)C=CC1=CC=C(O)C=C1 VNDDFIQMUQVYDJ-UHFFFAOYSA-N 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
241000700199 Cavia porcellus Species 0.000 description 4
206010014970 Ephelides Diseases 0.000 description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
229960002216 methylparaben Drugs 0.000 description 4
238000012360 testing method Methods 0.000 description 4
229940067596 butylparaben Drugs 0.000 description 3
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
230000037311 normal skin Effects 0.000 description 3
239000002674 ointment Substances 0.000 description 3
229940032094 squalane Drugs 0.000 description 3
229940099259 vaseline Drugs 0.000 description 3
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
229920000877 Melamine resin Polymers 0.000 description 2
239000000637 Melanocyte-Stimulating Hormone Substances 0.000 description 2
108010007013 Melanocyte-Stimulating Hormones Proteins 0.000 description 2
235000019482 Palm oil Nutrition 0.000 description 2
229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
229920001214 Polysorbate 60 Polymers 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
230000007815 allergy Effects 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
239000004359 castor oil Substances 0.000 description 2
235000019438 castor oil Nutrition 0.000 description 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
239000002537 cosmetic Substances 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
210000002615 epidermis Anatomy 0.000 description 2
239000011888 foil Substances 0.000 description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
229940075507 glyceryl monostearate Drugs 0.000 description 2
JDSHMPZPIAZGSV-UHFFFAOYSA-N melamine Chemical compound NC1=NC(N)=NC(N)=N1 JDSHMPZPIAZGSV-UHFFFAOYSA-N 0.000 description 2
230000008099 melanin synthesis Effects 0.000 description 2
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
GWEYIZUAQPNBAO-UHFFFAOYSA-N n-hexyl-3-(4-hydroxyphenyl)prop-2-enamide Chemical compound CCCCCCNC(=O)C=CC1=CC=C(O)C=C1 GWEYIZUAQPNBAO-UHFFFAOYSA-N 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
239000003921 oil Substances 0.000 description 2
235000019198 oils Nutrition 0.000 description 2
239000002540 palm oil Substances 0.000 description 2
150000002978 peroxides Chemical class 0.000 description 2
239000000049 pigment Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
230000001603 reducing effect Effects 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
150000005206 1,2-dihydroxybenzenes Chemical class 0.000 description 1
125000006040 2-hexenyl group Chemical group 0.000 description 1
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
MZQTYFUVASWKRX-UHFFFAOYSA-N 3-(4-hydroxyphenyl)-n-propylprop-2-enamide Chemical compound CCCNC(=O)C=CC1=CC=C(O)C=C1 MZQTYFUVASWKRX-UHFFFAOYSA-N 0.000 description 1
POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
239000005995 Aluminium silicate Substances 0.000 description 1
208000019300 CLIPPERS Diseases 0.000 description 1
206010008570 Chloasma Diseases 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
239000004378 Glycyrrhizin Substances 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
239000002211 L-ascorbic acid Substances 0.000 description 1
235000000069 L-ascorbic acid Nutrition 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
241000772415 Neovison vison Species 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
206010040880 Skin irritation Diseases 0.000 description 1
229920002125 Sokalan® Polymers 0.000 description 1
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
229930003268 Vitamin C Natural products 0.000 description 1
206010047642 Vitiligo Diseases 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
230000032683 aging Effects 0.000 description 1
229960000458 allantoin Drugs 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
235000012211 aluminium silicate Nutrition 0.000 description 1
238000010171 animal model Methods 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
238000004061 bleaching Methods 0.000 description 1
239000007844 bleaching agent Substances 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000012000 cholesterol Nutrition 0.000 description 1
208000021930 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids Diseases 0.000 description 1
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
230000009982 effect on human Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
210000000245 forearm Anatomy 0.000 description 1
LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
229960004949 glycyrrhizic acid Drugs 0.000 description 1
UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
235000019410 glycyrrhizin Nutrition 0.000 description 1
LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000003906 humectant Substances 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000007794 irritation Effects 0.000 description 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
230000003780 keratinization Effects 0.000 description 1
210000002510 keratinocyte Anatomy 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
125000002463 lignoceryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000000691 measurement method Methods 0.000 description 1
210000002752 melanocyte Anatomy 0.000 description 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
238000002156 mixing Methods 0.000 description 1
125000001421 myristyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
UYEKGCPLNBQNSM-UHFFFAOYSA-N n-cyclohexyl-3-(4-hydroxyphenyl)prop-2-enamide Chemical compound C1=CC(O)=CC=C1C=CC(=O)NC1CCCCC1 UYEKGCPLNBQNSM-UHFFFAOYSA-N 0.000 description 1
XOOAHGQKVZNTHU-UHFFFAOYSA-N n-ethyl-3-(4-hydroxyphenyl)prop-2-enamide Chemical compound CCNC(=O)C=CC1=CC=C(O)C=C1 XOOAHGQKVZNTHU-UHFFFAOYSA-N 0.000 description 1
125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
239000000419 plant extract Substances 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000008844 regulatory mechanism Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
230000000475 sunscreen effect Effects 0.000 description 1
239000000516 sunscreening agent Substances 0.000 description 1
238000010998 test method Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
229940042585 tocopherol acetate Drugs 0.000 description 1
229940045136 urea Drugs 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
239000010497 wheat germ oil Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
239000009538 yokuinin Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Birds (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

JP4684984A 1983-04-25 1984-03-12 メラニン抑制剤 Granted JPS60190713A (ja)

Priority Applications (5)

Application Number	Priority Date	Filing Date	Title
JP4684984A JPS60190713A (ja)	1984-03-12	1984-03-12	メラニン抑制剤
GB08410127A GB2141626B (en)	1983-04-25	1984-04-18	Cinnamic acid derivatives for lightening melanin pigmentation of skin
FR8406503A FR2545355B1 (fr)	1983-04-25	1984-04-25	Inhibiteur de melanine, a base d'un derive d'acide cinnamique
DE19843415413 DE3415413A1 (de)	1983-04-25	1984-04-25	Melanin-inhibitor
US06/814,172 US4978523A (en)	1983-04-25	1985-12-24	Melanin inhibitor

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP4684984A JPS60190713A (ja)	1984-03-12	1984-03-12	メラニン抑制剤

Publications (2)

Publication Number	Publication Date
JPS60190713A JPS60190713A (ja)	1985-09-28
JPH0425922B2 true JPH0425922B2 (de)	1992-05-06

Family

ID=12758783

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP4684984A Granted JPS60190713A (ja)	1983-04-25	1984-03-12	メラニン抑制剤

Country Status (1)

Country	Link
JP (1)	JPS60190713A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2686019B2 (ja) *	1992-06-30	1997-12-08	科学技術振興事業団	シロアリ防除剤
TWI465272B (zh)	2009-08-06	2014-12-21	Ind Tech Res Inst	用於美白皮膚的組合物、植物萃取美白組合物與具有美白功能之組合物
JP5469013B2 (ja) *	2009-08-06	2014-04-09	財團法人工業技術研究院	皮膚美白用組成物、植物抽出皮膚美白組成物、および皮膚美白効果を有する組成物

1984
- 1984-03-12 JP JP4684984A patent/JPS60190713A/ja active Granted

Also Published As

Publication number	Publication date
JPS60190713A (ja)	1985-09-28

Publication	Publication Date	Title
JPH083034A (ja)	1996-01-09	グリセロールアルキルエーテル類の内容物を有する活性化合物組み合わせ、並びに上記活性化合物組み合わせを含んでいる化粧品および皮膚科学調合物
KR20010049430A (ko)	2001-06-15	산소-불안정성 종을 안정화시키기 위한 조성물
JP2002506821A (ja)	2002-03-05	皮膚刺激の治療方法
JP2764510B2 (ja)	1998-06-11	美白化粧料
JPH05213729A (ja)	1993-08-24	メラニン抑制剤
JPH06321752A (ja)	1994-11-22	美白剤
US4876084A (en)	1989-10-24	P-hydroxycinnamamide derivatives and melanin inhibitor comprising the same
JPH0425922B2 (de)	1992-05-06
JPH06172150A (ja)	1994-06-21	皮膚化粧料
JPH05105643A (ja)	1993-04-27	桂皮酸誘導体およびこれを有効成分とする美白化粧料
JPH01249714A (ja)	1989-10-05	皮膚化粧料
JPH05105621A (ja)	1993-04-27	桂皮酸エステル誘導体を有効成分とする美白化粧料
JPH06321764A (ja)	1994-11-22	美白剤
CN109195578A (zh)	2019-01-11	硫代磷酸酯衍生物作为皮肤脱色剂的用途
JPH09132527A (ja)	1997-05-20	メラニン産生抑制剤及び皮膚外用剤
JPH0322848B2 (de)	1991-03-27
JPS63253014A (ja)	1988-10-20	メラニン抑制剤
JPH0692833A (ja)	1994-04-05	皮膚外用剤
JPS6256459A (ja)	1987-03-12	Ｎ，Ｎ−ジアルキル−ｐ−ヒドロキシシンナムアミド及びこれを含有するメラニン抑制剤
JPH06321747A (ja)	1994-11-22	皮膚外用剤
JPS6339847A (ja)	1988-02-20	ｐ−ヒドロキシシンナムアミド誘導体およびこれを含有するメラニン抑制剤
JPH0761919A (ja)	1995-03-07	美白剤
JP2001131050A (ja)	2001-05-15	皮膚化粧料
JPH06312920A (ja)	1994-11-08	美白剤及びこれを含有する皮膚化粧料
JPS63145211A (ja)	1988-06-17	ビタミン配合化粧料