JP7520031B2 - Antiperspirant Composition - Google Patents

Description

The present invention relates to an antiperspirant composition.

2. Description of the Related Art Antiperspirant compositions containing an antiperspirant component having an antiperspirant effect, such as aluminum chlorohydrate, have been widely used (see, for example, Patent Document 1).
Aluminum chlorohydrate exerts an antiperspirant effect by blocking sweat glands with a plug, but when the amount of sweat increases due to long-term sweating, the plug dissolves due to sweat, and the antiperspirant effect decreases. However, sufficient research has not been conducted to prevent the plug from dissolving due to sweat.

An antiperspirant composition that does not cause a feeling of tightness on the skin has also been proposed as an antiperspirant composition that contains an antiperspirant component such as chlorohydroxyaluminum (see Patent Document 2). However, the proposed antiperspirant composition has the problem that it does not provide a fully satisfactory antiperspirant effect.

A deodorant liniment containing aluminum chlorohydrate has also been proposed that has a high deodorant effect (see Patent Document 3). However, this proposed deodorant liniment not only does not have a fully satisfactory antiperspirant effect, but also has the problem of poor appearance due to the poor solubility of the ingredients.

Therefore, an antiperspirant composition that has excellent antiperspirant effects, does not cause tightness on the skin, and also has a good appearance has not yet been provided, and there is currently a strong demand for its prompt development.

JP 2003-095906 A JP 2017-048140 A Japanese Patent Application Publication No. 5-112440

The present invention aims to solve the above-mentioned problems in the prior art and to achieve the following objectives: That is, the present invention aims to provide an antiperspirant composition that has excellent antiperspirant effects and does not cause a tight feeling on the skin, and further has a good appearance.

As a result of intensive research conducted by the inventors in order to achieve the above-mentioned object, they have discovered that by containing (A) at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes, and (B) a water-soluble inorganic salt other than an aluminum salt having at least one counter ion selected from an alkali metal ion, a barium ion, and a magnesium ion, and by setting the mass ratio (A)/(B) of the content of the component (A) to the content of the component (B) to be 5 to 20, the plug due to the antiperspirant component does not dissolve, providing excellent antiperspirant effect, excellent lack of tightness on the skin, and further providing a good external appearance of the agent, even when the amount of sweat increases due to prolonged sweating.

The present invention is based on the above-mentioned findings of the present inventors, and the antiperspirant composition as a means for solving the above-mentioned problems contains (A) at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes, and (B) a water-soluble inorganic salt other than an aluminum salt having at least one counter ion selected from an alkali metal ion, a barium ion, and a magnesium ion, and the mass ratio (A)/(B) of the content of the component (A) to the content of the component (B) is 5 to 20.

The present invention can solve the above-mentioned problems of the conventional art and achieve the above-mentioned objective, thereby providing an antiperspirant composition that has excellent antiperspirant effect, does not cause tightness on the skin, and has a good appearance.

(Antiperspirant Composition)
The antiperspirant composition of the present invention contains at least (A) at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and complexes of aluminum halide hydrates, and (B) a water-soluble inorganic salt other than an aluminum salt having at least one counter ion selected from an alkali metal ion, a barium ion, and a magnesium ion, and preferably further contains at least any of (C) a copolymer or a salt thereof containing, as a monomer unit, at least one selected from monoalkyl maleate having an alkyl group with 1 to 4 carbon atoms, alkylacrylamide having an alkyl group with 1 to 8 carbon atoms, diacetone acrylamide, vinylpyrrolidone, and ethyl betaine methacrylate, (D) a hydroxyalkylated cyclodextrin, (E) a hydrophobized alkyl-modified alkyl cellulose, (F) at least one selected from bis-ethoxydiglycol succinate and bis-ethoxydiglycol cyclohexanedicarboxylate, and (G) ethanol, and further contains other components as necessary.

<(A) At least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes>
The at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes of the component (A) is contained mainly for the purpose of imparting an antiperspirant effect.

The antiperspirant component of component (A) is not particularly limited, so long as it is at least one selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes, and can be appropriately selected according to the purpose.

The aluminum halide may, for example, be aluminum chloride.
Examples of the aluminum halide hydrate include aluminum chlorohydrate, aluminum bromohydrate, and aluminum chlorohydrate/zirconium.
Examples of the aluminum halide hydrate complex include aluminum chlorohydrate/propylene glycol complex and aluminum chlorohydrate/zirconium.glycine complex.
These may be used alone or in combination of two or more.
Among these, aluminum chlorohydrate, aluminum chlorohydrate/propylene glycol complex, and aluminum chlorohydrate/zirconium glycine complex are preferred because of their excellent antiperspirant effect.

The antiperspirant component of the component (A) may be an appropriately synthesized product or a commercially available product.
Examples of commercially available products of the antiperspirant component of the component (A) include, by trade name, Aluminum (III) Chloride (manufactured by Tokyo Chemical Industry Co., Ltd., aluminum chloride), 50% aqueous solution of chlorohydroxyaluminum (manufactured by Taki Chemical Industry Co., Ltd., chlorohydroxyaluminum), REHYDROL II (manufactured by ELEMENTIS, chlorohydroxyaluminum/propylene glycol complex), and Reach AZO-956G (manufactured by ELEMENTIS, chlorohydroxyaluminum/zirconium glycine complex).

The content of the antiperspirant component in the (A) component is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoints of antiperspirant effect and lack of tightness on the skin, it is preferably 6% to 15% by mass, and more preferably 10% to 15% by mass, relative to the total amount of the antiperspirant composition. If the content of the (A) component is 6% by mass or more, the antiperspirant effect is good, and if it is 15% by mass or less, the lack of tightness on the skin is good.

<(B) Water-soluble inorganic salt other than aluminum salt having at least one ion selected from alkali metal ion, barium ion, and magnesium ion as a counter ion>
The water-soluble inorganic salt other than an aluminum salt having at least one ion selected from an alkali metal ion, a barium ion, and a magnesium ion as a counter ion of the component (B) is contained mainly for the purpose of imparting an antiperspirant effect.

The water-soluble inorganic salt of component (B) is not particularly limited as long as it is a water-soluble inorganic salt other than an aluminum salt, and can be appropriately selected according to the purpose. Examples include sulfates, carbonates, bicarbonates, and hydrochlorides. These may be used alone or in combination of two or more. Among these, at least one selected from sulfates, carbonates, and hydrochlorides is preferable in terms of excellent antiperspirant effect.

The salt has a counter ion of at least one selected from an alkali metal ion, a barium ion, and a magnesium ion.
Examples of the alkali metal ion include sodium ion and potassium ion.
Among these, the counter ion is preferably a sodium ion, a potassium ion, or a magnesium ion.

Examples of the sulfate include sodium sulfate, potassium sulfate, barium sulfate, and magnesium sulfate.
Examples of the carbonate include sodium carbonate, potassium carbonate, barium carbonate, and magnesium carbonate.
Examples of the bicarbonate include sodium bicarbonate and potassium bicarbonate.
Examples of the hydrochloride include sodium chloride, potassium chloride, barium chloride, and magnesium chloride.
Among these, sulfates are preferred, and sodium sulfate, potassium sulfate, magnesium sulfate, and barium sulfate are more preferred, since they can quickly form a strong plug that is not easily dissolved by sweat even when the amount of sweat increases due to long-term sweating, and can improve the antiperspirant effect and the appearance of the agent.

The water-soluble inorganic salt other than the aluminum salt of the component (B) may be appropriately synthesized or a commercially available product.
Examples of commercially available water-soluble inorganic salts other than the aluminum salt of component (B) include, by trade name, neutral anhydrous Glauber's salt (anhydrous sodium sulfate, manufactured by Nippon Chemical Industry Co., Ltd.), anhydrous sodium sulfate (Tomita Pharmaceutical Co., Ltd.), magnesium sulfate (anhydrous) (manufactured by Wako Pure Chemical Industries, Ltd.), sodium carbonate (manufactured by Takasugi Pharmaceutical Co., Ltd.), and sodium chloride (manufactured by Junsei Chemical Co., Ltd.).

The content of the water-soluble inorganic salt other than the aluminum salt of the (B) component is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoint of antiperspirant effect and appearance of the agent, it is preferably 0.6% to 3.0% by mass, and more preferably 0.8% to 2.0% by mass, based on the total amount of the antiperspirant composition. When the content of the (B) component is 0.6% by mass or more, the antiperspirant effect is good, and when it is 3.0% by mass or less, the antiperspirant effect and appearance of the agent are good.

<Mass ratio (A)/(B)>
The mass ratio (A)/(B) of the content (mass%) of the (A) component to the content (mass%) of the (B) component is 5 or less from the viewpoints of antiperspirant effect and appearance of the agent. The mass ratio (A)/(B) is preferably 5 to 11. If the mass ratio (A)/(B) is less than 5, the antiperspirant effect and the appearance of the agent become insufficient, and if it exceeds 20, the antiperspirant effect becomes insufficient. On the other hand, when the mass ratio (A)/(B) is from 5 to 20, it is advantageous in that the antiperspirant effect and the appearance of the agent are good.

<(C) A copolymer or a salt thereof containing, as a monomer unit, at least one selected from monoalkyl maleate having an alkyl group with 1 to 4 carbon atoms, alkylacrylamide having an alkyl group with 1 to 8 carbon atoms, diacetoneacrylamide, vinylpyrrolidone, and ethyl methacrylate betaine>
In addition to the components (A) and (B), the antiperspirant composition preferably further contains, as a component (C), a copolymer or a salt thereof containing, as a monomer unit, at least one selected from monoalkyl maleate having an alkyl group with a carbon number of 1 to 4, alkylacrylamide having an alkyl group with a carbon number of 1 to 8, diacetoneacrylamide, vinylpyrrolidone, and ethyl betaine methacrylate, in order to impart a more excellent antiperspirant effect and a feeling of no tightness to the skin. When the antiperspirant composition contains the component (C), it preferably further contains a component (G) described below.

Examples of copolymers or salts thereof that contain the monoalkyl maleate having 1 to 4 carbon atoms as a monomer unit include (vinyl methyl ether/ethyl maleate) copolymer and (vinyl methyl ether/butyl maleate) copolymer.

Examples of copolymers or salts thereof that contain alkylacrylamide, whose alkyl group has 1 to 8 carbon atoms as a monomer unit, include (acrylates/alkyl acrylate (C1-18)/alkyl (C1-8) acrylamide) copolymers or salts thereof. The "C" above represents the number of carbon atoms in the alkyl group.

Examples of copolymers or salts thereof that contain diacetone acrylamide as a monomer unit include (acrylates/diacetone acrylamide) copolymers or salts thereof.

An example of a copolymer or salt thereof containing vinylpyrrolidone as a monomer unit is vinylpyrrolidone/vinyl acetate copolymer.

Examples of the copolymer or salt thereof containing ethyl betaine methacrylate as a monomer unit include (ethyl betaine methacrylate/acrylates) copolymer or salt thereof.

The copolymer or salt thereof of component (C) may be used alone or in combination of two or more. Among these, (vinyl methyl ether/ethyl maleate) copolymer, (vinyl methyl ether/butyl maleate) copolymer, (acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide) copolymer or salt thereof, and (acrylates/diacetone acrylamide) copolymer or salt thereof are more preferred in terms of the lack of tightness on the skin.

The copolymer or salt thereof of component (C) may be the copolymer (unneutralized product) or its salt (neutralized product) used as is, or the copolymer (unneutralized product) may be converted into a salt using any alkaline agent, or the salt (neutralized product) of the copolymer may be desalted using any acid.

The alkaline agent is not particularly limited and can be appropriately selected depending on the purpose. Examples include ammonium, 2-amino-2-methyl-1-propanol (hereinafter sometimes referred to as "AMP"), and 2-amino-2-methyl-1,3-propanediol (hereinafter sometimes referred to as "AMPD"). These may be used alone or in combination of two or more. Among these, AMP is preferred.

The acid is not particularly limited and can be appropriately selected depending on the purpose. Examples of the acid include hydrochloric acid, sulfuric acid, etc. These may be used alone or in combination of two or more.

The desalting method is not particularly limited and can be appropriately selected from known methods. Specific examples of the desalting method include a method in which 1 g of (acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide) copolymer AMP is dissolved in 4 g of 95% by mass ethanol, and 65 μL of hydrochloric acid is added thereto for desalting to obtain (acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide) copolymer.

The copolymer or salt thereof of the component (C) may be an appropriately synthesized product or a commercially available product.
Commercially available copolymers of the component (C) or salts thereof include, for example, trade names of GANTREZ ES-225 (manufactured by Ashland Japan Co., Ltd., (vinyl methyl ether/ethyl maleate) copolymer), GANTREZ SP-215 (manufactured by Ashland Japan Co., Ltd., (vinyl methyl ether/ethyl maleate) copolymer), GANTREZ ES-425 (manufactured by Ashland Japan Co., Ltd., (vinyl methyl ether/butyl maleate) copolymer), PLUSSIZE L-9909B (manufactured by GOO Chemical Industry Co., Ltd., (acrylates/alkyl acrylate (C1-18)/alkyl (C1-8) acrylamide) copolymer), PLUSSIZE L-9909 (manufactured by GOO Chemical Industry Co., Ltd., (acrylates/alkyl acrylate (C1-18)/alkyl (C1-8) acrylamide) copolymer), PLUSSIZE Examples of such copolymers include L-6740B (manufactured by GOO Chemical Industry Co., Ltd., (acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide) copolymer), PLUSCISE L-6330 (manufactured by GOO Chemical Industry Co., Ltd., (acrylates/diacetone acrylamide) copolymer AMP), PVP/VA S-630 (manufactured by Ashland Japan Co., Ltd., (vinyl pyrrolidone/vinyl acetate) copolymer), and Yukaformer R205S (manufactured by Mitsubishi Chemical Corporation, (ethyl betaine methacrylate/acrylates) copolymer).

The content of the copolymer or salt thereof of the component (C) is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoints of antiperspirant effect, lack of tightness on the skin, and appearance of the agent, it is preferably 0.25% by mass to 1.5% by mass, and more preferably 0.5% by mass to 1.5% by mass, based on the total amount of the antiperspirant composition. When the content of the component (C) is 0.25% by mass or more, the antiperspirant effect and lack of tightness on the skin are good, and when it is 1.5% by mass or less, the appearance of the agent is good.

<(D) Hydroxyalkylated Cyclodextrin>
The antiperspirant composition preferably contains, in addition to the components (A) and (B), a hydroxyalkylated cyclodextrin as a component (D), in that excellent deodorizing effect can be imparted.

The hydroxyalkylated cyclodextrin of component (D) is a cyclodextrin in which hydroxyalkyl groups have been introduced into some of the hydroxyl groups of the cyclodextrin.

The cyclodextrin that is the raw material for the hydroxyalkylated cyclodextrin of component (D) is not particularly limited and can be appropriately selected depending on the purpose. Examples include α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin. These differ in the number of glucose molecules that make them up. The hydroxyalkylated cyclodextrin of component (D) is made from a raw material that contains one or more of these cyclodextrins.

The hydroxyalkyl group is not particularly limited and can be selected appropriately depending on the purpose. Examples of the hydroxyalkyl group include substituents such as hydroxymethyl, hydroxyethyl, hydroxypropyl, and hydroxybutyl.

The degree of substitution of the hydroxyalkyl group in the hydroxyalkylated cyclodextrin of component (D) is not particularly limited and can be selected appropriately depending on the purpose, but is preferably 1 to 14 from the viewpoint of solubility in water.

Specific examples of the hydroxyalkylated cyclodextrin of the component (D) include hydroxymethyl-α-cyclodextrin, hydroxymethyl-β-cyclodextrin, hydroxymethyl-γ-cyclodextrin, hydroxyethyl-α-cyclodextrin, hydroxyethyl-β-cyclodextrin, hydroxyethyl-γ-cyclodextrin, hydroxypropyl-α-cyclodextrin, hydroxypropyl-β-cyclodextrin, hydroxypropyl-γ-cyclodextrin, hydroxybutyl-α-cyclodextrin, hydroxybutyl-β-cyclodextrin, hydroxybutyl-γ-cyclodextrin, etc. These may be used alone or in combination of two or more.
Among these, hydroxypropyl-β-cyclodextrin is preferred in terms of its deodorizing effect, price, and availability.

The hydroxyalkylated cyclodextrin of the component (D) may be either an appropriately synthesized product or a commercially available product.
An example of a commercially available hydroxyalkylated cyclodextrin of the component (D) is Celdex HP-β-CD (Nihon Shokuhin Kako Co., Ltd., hydroxypropyl-β-cyclodextrin).

The content of the hydroxyalkylated cyclodextrin in the (D) component is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoints of deodorizing effect and dry feeling, it is preferably 0.1% to 5.0% by mass, and more preferably 0.1% to 2.5% by mass, based on the total amount of the antiperspirant composition. If the content of the (D) component is 0.1% by mass or more, the deodorizing effect is good, and if it is 5.0% by mass or less, the dry feeling is good.

<(E) Hydrophobized Alkyl-Modified Alkyl Cellulose>
It is preferable that the antiperspirant composition further contains a hydrophobized alkyl-modified alkyl cellulose as a component (E) in addition to the components (A) and (B), in that excellent non-stickiness after drying can be imparted to the composition.

The hydrophobic alkyl-modified alkyl cellulose of the component (E) is not particularly limited and can be appropriately selected according to the purpose. For example, dodecyloxyhydroxyalkyl cellulose (lauroxyhydroxyalkyl cellulose), tridecyloxyhydroxyalkyl cellulose, tetradecyloxyhydroxyalkyl cellulose (myristyloxyhydroxyalkyl cellulose), pentadecyloxyhydroxyalkyl cellulose, hexadecyloxyhydroxyalkyl cellulose (cetyloxyhydroxyalkyl cellulose), heptadecyloxyhydroxyalkyl cellulose, octadecyloxyhydroxyalkyl cellulose (stearoxyhydroxyalkyl cellulose), nonadecyloxyhydroxyalkyl cellulose, eicosyloxyhydroxyalkyl cellulose, heneicosyloxyhydroxyalkyl cellulose, docosyloxyhydroxyalkyl cellulose, etc. may be mentioned. These may be used alone or in combination of two or more. Among these, octadecyloxyhydroxypropyl methylcellulose (stearoxyhydroxypropyl methylcellulose) is preferred because of its excellent lack of stickiness after drying.

The hydrophobized alkyl-modified alkyl cellulose of the component (E) may be an appropriately synthesized product or a commercially available product.
Examples of commercially available hydrophobized alkyl-modified alkyl celluloses of the component (E) include, by trade name, Sangelose (registered trademark) 60L (manufactured by Daido Chemical Industry Co., Ltd., stearoxy hydroxypropyl methylcellulose), Sangelose (registered trademark) 60M (manufactured by Daido Chemical Industry Co., Ltd., stearoxy hydroxypropyl methylcellulose), Sangelose (registered trademark) 90L (manufactured by Daido Chemical Industry Co., Ltd., stearoxy hydroxypropyl methylcellulose), and Sangelose (registered trademark) 90M (manufactured by Daido Chemical Industry Co., Ltd., stearoxy hydroxypropyl methylcellulose).

The content of the hydrophobized alkyl-modified alkyl cellulose in component (E) is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoints of the appearance of the agent and non-stickiness after drying, it is preferably 0.1% to 1% by mass, and more preferably 0.1% to 0.5% by mass, based on the total amount of the antiperspirant composition. If the content of the hydrophobized alkyl-modified alkyl cellulose in component (E) is 0.1% by mass or more, the agent will have a good non-stickiness after drying, and if it is 1% by mass or less, the agent will have a good appearance.

<Mass ratio (B)/(E)>
The mass ratio (B)/(E) of the content (mass%) of the component (B) to the content (mass%) of the component (E) is not particularly limited and may be appropriately selected depending on the purpose. However, from the viewpoints of high-temperature storage stability and natural appearance after drying, the mass ratio (B) is preferably from 2.1 to 10, more preferably from 3 to 8, and particularly preferably from 3 to 5. When /(E) is 2.1 or more, high-temperature storage stability is good, and when it is 10 or less, high-temperature storage stability and a natural appearance after drying are good.

<(F) At least one selected from bis-ethoxydiglycol succinate and bis-ethoxydiglycol cyclohexanedicarboxylate>
The antiperspirant composition preferably contains, as a component (F), at least one selected from bis-ethoxydiglycol succinate and bis-ethoxydiglycol cyclohexanedicarboxylate, in addition to the components (A) and (B), in that excellent high-temperature storage stability and a natural appearance after drying can be imparted, and it is more preferable that the antiperspirant composition contains bis-ethoxydiglycol cyclohexanedicarboxylate, in that excellent high-temperature storage stability, a natural appearance after drying, and non-stickiness after drying can be imparted.

The present inventors have found that in an antiperspirant composition containing the (B) component, when the (C) component and the (E) component are further combined, the (C) component and the (E) component precipitate when stored under high temperature (e.g., 50°C) conditions, resulting in poor stability. The present inventors have intensively studied this problem and found that by further blending the (F) component, not only is storage stability under high temperature conditions improved, but the natural appearance after drying is also improved. Therefore, when the antiperspirant composition contains the (C) component and the (E) component, it is preferable that the composition further contains the (F) component.

At least one member selected from bisethoxydiglycol succinate and bisethoxydiglycol cyclohexanedicarboxylate of the component (F) may be appropriately synthesized or a commercially available product.
An example of a commercially available product of bis-ethoxydiglycol succinate, component (F), is Hi-Aquostar DCS (manufactured by Kokyu Alcohol Kogyo Co., Ltd.).
An example of a commercially available product of bisethoxydiglycol cyclohexanedicarboxylate, the component (F), is Neosolue-Aquilio (manufactured by Nippon Fine Chemicals Co., Ltd., bisethoxydiglycol cyclohexane-1,4-dicarboxylate).

The content of at least one selected from bisethoxydiglycol succinate and bisethoxydiglycol cyclohexanedicarboxylate in the component (F) is not particularly limited and can be appropriately selected depending on the purpose, but from the viewpoints of high-temperature storage stability, natural appearance after drying, and non-stickiness after drying, it is preferably 0.1% by mass to 5% by mass, and more preferably 0.5% by mass to 3% by mass, based on the total amount of the antiperspirant composition. When the content of at least one selected from bisethoxydiglycol succinate and bisethoxydiglycol cyclohexanedicarboxylate in the component (F) is 0.1% by mass or more, high-temperature storage stability and natural appearance after drying are good, and when it is 5% by mass or less, non-stickiness after drying is good.

<(G) Ethanol>
The antiperspirant composition preferably contains ethanol as a component (G) in addition to the components (A) and (B) in that excellent high-temperature heat retention stability can be imparted to the composition.
The ethanol of the component (G) may be absolute ethanol or water-containing ethanol.

The ethanol of the component (G) may be appropriately synthesized or may be a commercially available product.
Examples of commercially available ethanol as the component (G) include synthetic alcohol 95% (manufactured by Japan Alcohol Sales Co., Ltd.) and synthetic specified alcohol 95% (manufactured by Shinwa Alcohol Industry Co., Ltd.).

The ethanol content of the (G) component is not particularly limited and may be appropriately selected depending on the purpose, but from the viewpoint of high-temperature storage stability, it is preferably 20% to 50% by mass, and more preferably 25% to 50% by mass, based on the total amount of the antiperspirant composition. When the ethanol content of the (G) component is 20% by mass or more or 50% by mass or less, high-temperature storage stability is good. In this specification, the ethanol content of the (G) component is the content converted into anhydrous ethanol.

<Other ingredients>
In addition to the components (A) to (G), the antiperspirant composition may contain other components within a range that does not impair the effects of the present invention. The other components are not particularly limited and may be appropriately selected depending on the purpose, and examples of such other components include water or solvents such as purified water, ion-exchanged water, and pure water; disinfectants such as triclosan, isopropylmethylphenol, and benzalkonium chloride; usability-improving powders such as nylon powder, polyethylene powder, silicic anhydride, silicone powder, cellulose powder, talc, kaolin, and mica; deodorant powders such as porous magnesia silica powder, synthetic layered magnesium pyrosilicate powder, calcium alginate powder (secondary agglomerates), and apatite powder; and the like. Examples of suitable additives include preservatives such as bentonite and sodium benzoates; skin protective agents such as bentonite and stearyl glycyrrhetinate; moisturizers such as glycerin, hyaluronic acid, and urea; plant extracts such as aloe extract, eucalyptus extract, and white birch extract; viscosity adjusters such as hydroxypropyl cellulose and hydroxymethyl cellulose; ultraviolet absorbers such as urocanic acid, para-aminobenzoic acid, isopropyl para-methoxycinnamate, and hydroxymethoxybenzophenone; antioxidants such as tocopherol; cooling agents such as menthol and menthyl lactate; pigments; and fragrances.
The content of the other components in the antiperspirant composition is not particularly limited as long as it does not impair the effects of the present invention, and can be appropriately selected depending on the purpose.

-pH-
The pH of the antiperspirant composition at 25° C. is not particularly limited and may be appropriately selected depending on the purpose, but is preferably 3.5 to 6.0 from the viewpoints of antiperspirant effect and appearance of the agent.

-viscosity-
The viscosity of the antiperspirant composition is not particularly limited and may be appropriately selected depending on the purpose. In the case of a liquid, the viscosity is preferably 1.0 mPa·s to 2,000 mPa·s at 25° C. from the viewpoint of antiperspirant effect.

The viscosity can be measured by adjusting the temperature of the antiperspirant composition to 25°C, setting it in, for example, a BM type viscometer (using a No. 1 rotor or a No. 2 rotor), rotating the rotor at a rotation speed of 60 rpm, and waiting one minute after the rotor starts to rotate.

-Dosage form-
The formulation of the antiperspirant composition is not particularly limited and may be appropriately selected depending on the purpose, and examples thereof include liquid types, solid types, semi-solid types, gel types, etc. Among these, the liquid and gel types are preferred, and the liquid type is more preferred, because application to the skin in a state dissolved in water is effective for achieving the desired effect, and the composition can be applied with high adhesion to achieve a high level of effect.

Examples of the liquid type include a roll-on type, a mist spray type, and a lotion type.
The solid type includes, for example, a stick type and a sheet type.
The semi-solid type includes, for example, a cream type.
The gel type includes, for example, a gel type.
Among these, the roll-on type is preferred from the viewpoint of antiperspirant effect.

When the antiperspirant composition is of the roll-on type, it is preferable that the antiperspirant product is composed of the antiperspirant composition and a roll-on container having an application ball filled with the antiperspirant composition. The roll-on type preparation is such that the antiperspirant composition is contained in a known roll-on container, the antiperspirant composition is attached to a ball in a state where a part of the ball is exposed to the roll-on container and is rotatably held by a holder, and the ball is attached to the skin when in use, thereby allowing the antiperspirant composition to be applied to the skin.
The antiperspirant composition can also be suitably used as a gel preparation in which the antiperspirant composition is filled into a bottle container and applied directly from the container, as a gel preparation to be applied using fingertips or hands, or as a lotion preparation.

-container-
Examples of containers that can be used for each of the above types include roll-on containers, bottle containers for gels, bottle containers for lotions, and trigger-type spray containers for mist. Among these, roll-on containers are preferred from the viewpoint of ease of application to the skin. The roll-on containers can be suitably used in that the antiperspirant composition can be applied closely to the skin and can exert an antiperspirant effect.

The roll-on container is not particularly limited as long as it can be filled with the antiperspirant composition, and can be appropriately selected depending on the purpose. Examples include the containers described in JP 2005-186997 A; containers consisting of a bottle (material: HDPE natural, full capacity: approximately 56 mL, body diameter: approximately 33 mm in diameter, height: approximately 87 mm, manufactured by Yoshino Kogyosho Co., Ltd.), a ring (material: LLDPE natural, outer diameter: approximately 26 mm, height: approximately 18 mm, manufactured by Yoshino Kogyosho Co., Ltd.), and a bowl (material: PP white, diameter: approximately 20 mm, manufactured by Yoshino Kogyosho Co., Ltd.).

The bottle container for gel is not particularly limited as long as it can be filled with the antiperspirant composition, and can be appropriately selected depending on the purpose. Examples include containers consisting of a bottle (product name: TOMII, material: HDPE natural, full capacity: approximately 34 mL, body diameter: approximately 39 mm in diameter x 24 mm (oval), height: approximately 76 mm, manufactured by Takemoto Container Co., Ltd.), an inner stopper (product name: Nozzle B for TO Cap, material: PE natural, outer diameter: approximately 12 mm, height: approximately 13 mm, manufactured by Takemoto Container Co., Ltd.), and a cap (product name: TO Cap, material: AS/PP white, outer diameter: approximately 37 mm in diameter x 23 mm (oval), height: approximately 22 mm, manufactured by Takemoto Container Co., Ltd.).

The bottle container for the lotion is not particularly limited as long as it can be filled with the antiperspirant composition, and can be appropriately selected depending on the purpose. Examples include containers consisting of a bottle (product name: TOMIII-50, material: HDPE natural, full capacity: approximately 34 mL, body diameter: approximately 42 mm in diameter x 29 mm (oval), height: approximately 88 mm, manufactured by Takemoto Container Co., Ltd.), an inner stopper (product name: Nozzle A for TO Cap, material: PE natural, outer diameter: approximately 12 mm, height: approximately 13 mm, manufactured by Takemoto Container Co., Ltd.), and a cap (product name: TOMIII Cap, material: PP white, outer diameter: approximately 37 mm in diameter x 25 mm (oval), height: approximately 24 mm, manufactured by Takemoto Container Co., Ltd.).

There are no particular limitations on the mist trigger container, so long as it can be filled with the antiperspirant composition, and it can be appropriately selected depending on the purpose. Examples include containers consisting of a bottle (product name: PH-100, material: natural PE, full capacity: approximately 100 mL, body diameter: approximately 40 mm in diameter, height: approximately 120 mm, manufactured by Kamimura Chemical Co., Ltd.) and a trigger (product name: Z-305, average diameter of spray hole: 0.45 mm, manufactured by Mitani Valve Co., Ltd.).

-Production method-
The method for producing the antiperspirant composition is not particularly limited and may be appropriately selected depending on the purpose, and may be produced, for example, by mixing the component (A) and the component (B), preferably at least one of the components (C), (D), (E), (F), and (G), and further, if necessary, the other components and water (the balance being blended so that the total of the antiperspirant composition is 100 mass %). In producing the antiperspirant composition, the component (A), the component (B), the component (C), the component (D), the component (E), the component (F), the component (G), and the other components may be used alone in the preparation, or may be used in the form of a mixture containing two or more components.

A specific example of a method for producing the antiperspirant composition is to add component (B) to water and dissolve it uniformly, then add component (A) and dissolve it uniformly. Then, add components (D) and (E) and dissolve them uniformly, and then add component (G) in which components (C) and (F) have been uniformly dissolved, mix and dissolve uniformly to obtain the antiperspirant composition.

The device for preparing the antiperspirant composition is not particularly limited and can be appropriately selected depending on the purpose. For example, a stirring device equipped with multiple stirring blades (propeller, turbine, disperser, etc.) capable of shearing and total mixing can be used.

--Applications--
The antiperspirant composition of the present invention has an excellent antiperspirant effect and is free of any tight feeling on the skin, and further has a good appearance, and therefore can be used widely in cosmetics, medicines, quasi-drugs, etc., and can be more suitably used in antiperspirants, deodorants, antiperspirant deodorants, and deodorants.

The present invention will be specifically explained below with reference to examples, comparative examples, and formulation examples, but the present invention is in no way limited to these examples and formulation examples.

The content of each component described in the Examples, Comparative Examples, and Formulation Examples is shown in mass %, and all values are converted into pure content. In addition, the mass ratio (A)/(B) between the content (mass %) of the (A) component and the content (mass %) of the (B) component, and the mass ratio (B)/(E) between the content (mass %) of the (B) component and the content (mass %) of the (E) component are rounded off to the first decimal place and calculated to the first decimal place and described. In addition, ethanol of the (G) component is synthetic alcohol 95 degrees (manufactured by Japan Alcohol Sales Co., Ltd.), and the anhydrous ethanol equivalent value (content (mass %) converted into anhydrous ethanol) is described.

(Examples 1 to 9 and Comparative Examples 1 to 5)
Antiperspirant compositions having the compositions and contents shown in Tables 1 and 7 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) or a comparative component for component (A) and a fragrance as a common component were added and uniformly dissolved to obtain the antiperspirant compositions of Examples 1 to 9 and Comparative Examples 1 to 5.

The obtained antiperspirant compositions of Examples 1 to 9 and Comparative Examples 1 to 5 were each filled in a roll-on container of the following specifications in an amount of 40 mL.
-Roll-on container-
Bottle (Material: HDPE natural, full capacity: approx. 56 mL, body diameter: approx. 33 mm, height: approx. 87 mm, manufactured by Yoshino Kogyosho Co., Ltd.)
- Ring (material: LLDPE natural, outer diameter: approx. 26 mm, height: approx. 18 mm, manufactured by Yoshino Kogyosho Co., Ltd.)
・Ball (material: white PP, diameter: approx. 20 mm, manufactured by Yoshino Kogyosho Co., Ltd.)

(Examples 10 to 17)
Antiperspirant compositions having the compositions and contents shown in Table 2 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) was added and uniformly dissolved, followed by adding component (G) and a fragrance as a common component, which were mixed and uniformly dissolved to obtain the antiperspirant compositions of Examples 10 to 17.
The obtained antiperspirant compositions of Examples 10 to 17 were each filled in a roll-on container of the same specifications as those of Examples 1 to 9 and Comparative Examples 1 to 5 in an amount of 40 mL.

(Examples 18 to 25)
Antiperspirant compositions having the compositions and contents shown in Table 3 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) was added and uniformly dissolved. Thereafter, component (C) was uniformly dissolved in component (G), and the fragrance as a common component was added, mixed, and uniformly dissolved to obtain the antiperspirant compositions of Examples 18 to 25.
The obtained antiperspirant compositions of Examples 18 to 25 were each filled in a roll-on container of the same specifications as those of Examples 1 to 9 and Comparative Examples 1 to 5 in an amount of 40 mL.

(Examples 26 to 29)
Antiperspirant compositions having the compositions and contents shown in Table 4 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) was added and uniformly dissolved. Then, component (D) was added and uniformly dissolved, and then component (C) was uniformly dissolved in component (G), and the fragrance as a common component was added, mixed, and uniformly dissolved to obtain the antiperspirant compositions of Examples 26 to 29.
The obtained antiperspirant compositions of each of Examples 26 to 29 were filled in a roll-on container having the same specifications as those of Examples 1 to 9 and Comparative Examples 1 to 5 in an amount of 40 mL.

(Examples 30 to 41)
Antiperspirant compositions having the compositions and contents shown in Tables 5 and 6 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) was added and uniformly dissolved. Then, component (E) was added and uniformly dissolved, and then component (G) in which components (C) and (F) were uniformly dissolved, and a fragrance as a common component were added, mixed, and uniformly dissolved to obtain the antiperspirant compositions of Examples 30 to 41.
The obtained antiperspirant compositions of each of Examples 30 to 41 were filled in a roll-on container having the same specifications as those of Examples 1 to 9 and Comparative Examples 1 to 5 in an amount of 40 mL.

The prepared antiperspirant compositions (roll-on type) of Examples 1 to 41 and Comparative Examples 1 to 5 were evaluated for "antiperspirant effect," "lack of tightness on the skin," and "appearance of the agent" using the evaluation methods described below. The antiperspirant compositions (roll-on type) of Examples 26 to 29 were further evaluated for "deodorizing effect" and "smooth feeling" using the evaluation methods described below. The antiperspirant compositions (roll-on type) of Examples 30 to 41 were further evaluated for "high temperature storage stability," "lack of stickiness after drying," and "natural appearance after drying" using the evaluation methods described below. The results are shown in Tables 1 to 7 below.

<Anti-perspirant effect>
0.40 g of each of the antiperspirant compositions of Examples 1 to 41 and Comparative Examples 1 to 5 was applied to one armpit of six expert panelists and allowed to dry. The other armpit was used as a control (no antiperspirant composition was applied). Thereafter, sweat absorbing pads were attached to both armpits, and exercise was performed on a fitness bike for 20 minutes under high temperature conditions (38° C., 40% RH environment). The amount of sweating in the area where the antiperspirant composition was applied and the area where the antiperspirant composition was not applied was measured from the weight change of the sweat absorbing pad. The antiperspirant rate was calculated based on the following formula (1), and the average value of the antiperspirant rates of the six expert panelists was calculated. From the average value of the antiperspirant rates, the "antiperspirant effect" was evaluated based on the following evaluation criteria.
Antiperspirant rate (%)=100−amount of sweating in area where antiperspirant composition is applied/amount of sweating in area where antiperspirant composition is not applied×100 Formula (1)
- Evaluation criteria for "antiperspirant effect" -
◎◎: Average sweat control rate is 65% or more and 100% or less ◎: Average sweat control rate is 55% or more and less than 65% ○: Average sweat control rate is 45% or more and less than 55% △: Average sweat control rate is 10% or more and less than 45% ×: Average sweat control rate is 0% or more and less than 10%

<No tightness on the skin>
0.40 g of each of the antiperspirant compositions of Examples 1 to 41 and Comparative Examples 1 to 5 was applied to the armpits of 20 expert panelists, allowed to dry, and then evaluated for "freedom of tightness of the skin" based on the following evaluation criteria.
- Evaluation criteria for "no tightness of skin" -
◎◎: 18 to 20 out of 20 expert panelists answered "skin does not feel tight" ◎: 15 to 17 out of 20 expert panelists answered "skin does not feel tight" ○: 11 to 14 out of 20 expert panelists answered "skin does not feel tight" △: 6 to 10 out of 20 expert panelists answered "skin does not feel tight" ×: 5 or less out of 20 expert panelists answered "skin does not feel tight"

<Appearance of the drug>
50 g of each of the antiperspirant compositions of Examples 1 to 41 and Comparative Examples 1 to 5 was placed in a glass vial, and the appearance was observed at room temperature (25° C.), and the "appearance of the agent" was evaluated based on the following evaluation criteria.
- Evaluation criteria for "appearance of the drug" -
◎◎: The appearance of the agent is very good (it is a transparent liquid).
◎: Appearance of the agent is good (slightly translucent liquid)
○: The appearance of the agent is somewhat good (it is a translucent liquid)
△: Appearance of the agent is slightly poor (it is a cloudy liquid)
×: Appearance of the agent is poor (liquid with precipitates)

<Deodorizing effect>
Eight expert panelists were each applied 0.40 g of each of the antiperspirant compositions of Examples 26 to 29 under their armpits and allowed to dry. They then exercised on a fitness bike for 20 minutes under high temperature conditions (38° C., 40% RH environment). 20 hours after application of the antiperspirant composition, the odor in the armpits was evaluated using the following 6-level odor intensity rating method. The average odor intensity of the eight expert panelists was calculated. The "deodorizing effect" was evaluated from the average odor intensity based on the following evaluation criteria.
- Six-level odor intensity rating system -
0 points: no odor 1 point: barely detectable odor 2 points: weak odor that is easy to identify 3 points: easily detectable odor 4 points: strong odor 5 points: intense odor - Evaluation criteria for "deodorizing effect" -
◎: Average odor intensity is 0 points or more and less than 2 points. ○: Average odor intensity is 2 points or more and less than 3 points. △: Average odor intensity is 3 points or more and less than 4 points. ×: Average odor intensity is 4 points or more and less than 5 points.

<Smooth feeling>
0.40 g of each of the antiperspirant compositions of Examples 26 to 29 was applied to one armpit of 30 expert panelists and allowed to dry. The other armpit was used as a control (no antiperspirant composition was applied). Regarding the dry feel of the skin, if each expert panelist felt that the area where the antiperspirant composition was applied was clearly dryer than the control (area where the antiperspirant composition was not applied) 8 hours after application of the antiperspirant composition, the case was judged to be "excellent in dry feel," and the "dry feel" was evaluated based on the following evaluation criteria.
- Evaluation criteria for "smooth feel" -
◎: 25 to 30 out of 30 expert panelists answered "Excellent smooth feeling" ○: 20 to 24 out of 30 expert panelists answered "Excellent smooth feeling" △: 10 to 19 out of 30 expert panelists answered "Excellent smooth feeling" ×: 9 or less out of 30 expert panelists answered "Excellent smooth feeling"

<High temperature storage stability>
50 g of each of the antiperspirant compositions of Examples 30 to 41 was placed in a glass vial and allowed to stand at 50° C. for one month. After that, the appearance was observed and the "high-temperature storage stability" was evaluated based on the following evaluation criteria.
- Evaluation criteria for "high temperature storage stability" -
◎◎: Very good high-temperature storage stability (no foreign matter whatsoever)
◎: Good high-temperature storage stability (very small amount of precipitate on the gas-liquid interface)
○: Fairly good high-temperature storage stability (some precipitates on the gas-liquid interface)
△: Slightly poor high-temperature storage stability (precipitates are present at the gas-liquid interface)
×: Poor high-temperature storage stability (precipitates are so large that they peel off from the gas-liquid surface)

<Non-sticky after drying>
0.40 g of each of the antiperspirant compositions of Examples 30 to 41 was applied to one armpit of 20 expert panelists, and after drying, the "absence of stickiness after drying" was evaluated based on the following evaluation criteria.
- Evaluation criteria for "non-stickiness after drying" -
◎: 16 to 20 out of 20 expert panelists answered that it was not sticky. ○: 11 to 15 out of 20 expert panelists answered that it was not sticky. △: 6 to 10 out of 20 expert panelists answered that it was not sticky. ×: 5 or less out of 20 expert panelists answered that it was not sticky.

<Natural appearance after drying>
0.40 g of each of the antiperspirant compositions of Examples 30 to 41 was applied to one armpit of 20 expert panelists, allowed to dry, and then the "natural appearance after drying" was evaluated based on the following evaluation criteria.
- Evaluation criteria for "natural appearance after drying" -
◎: 16 to 20 out of 20 expert panelists answered that it looks natural. ○: 11 to 15 out of 20 expert panelists answered that it looks natural. △: 6 to 10 out of 20 expert panelists answered that it looks natural. ×: 5 or less out of 20 expert panelists answered that it looks natural.

(Formulation Examples 1 to 5)
Antiperspirant compositions having the compositions and contents shown in Table 8 below were prepared by a conventional method.
Specifically, component (B) was added to water and uniformly dissolved, and then component (A) was added and uniformly dissolved. Then, components (D) and (E) were added and uniformly dissolved, and then components (C) and (F) were uniformly dissolved in component (G), and a fragrance as a common component was added, mixed, and uniformly dissolved to obtain the antiperspirant compositions of Formulation Examples 1 to 5.
Each of the obtained antiperspirant compositions was filled in a roll-on container having the same specifications as those of Examples 1 to 9 and Comparative Examples 1 to 5 in an amount of 40 mL.

The prepared antiperspirant compositions (roll-on type) of Formulation Examples 1 to 5 were evaluated for "antiperspirant effect," "absence of tightness on the skin," "appearance of the agent," "high-temperature storage stability," "deodorizing effect," "smooth feeling," "absence of stickiness after drying," and "natural appearance after drying" using the same evaluation methods as in Examples 26 to 41. The results are shown in Table 8 below.

Details of each component used in the above examples, comparative examples, and formulation examples are shown in Table 9 below.

The aspects of the present invention include, for example, the following.
<1> (A) at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes;
(B) a water-soluble inorganic salt other than an aluminum salt having at least one counter ion selected from an alkali metal ion, a barium ion, and a magnesium ion;
Contains
The antiperspirant composition is characterized in that the mass ratio (A)/(B) of the content of the component (A) to the content of the component (B) is 5 to 20.
<2> (C) a copolymer or a salt thereof containing, as a monomer unit, at least one selected from the group consisting of monoalkyl maleate having an alkyl group with 1 to 4 carbon atoms, alkylacrylamide having an alkyl group with 1 to 8 carbon atoms, diacetoneacrylamide, vinylpyrrolidone, and ethyl methacrylate betaine, and (G) ethanol,
The antiperspirant composition according to <1>, further comprising:
<3> (E) a hydrophobized alkyl-modified alkyl cellulose, and (F) at least one selected from bis-ethoxydiglycol succinate and bis-ethoxydiglycol cyclohexanedicarboxylate,
The antiperspirant composition according to <2> above, further comprising:
<4> The antiperspirant composition according to <3>, wherein a mass ratio (B)/(E) of a content of the component (B) to a content of the component (E) is 2.1 to 10.
<5> The antiperspirant composition according to any one of <1> to <4>, further comprising (D) a hydroxyalkylated cyclodextrin.
<6> The antiperspirant composition according to any one of <1> to <5>, wherein the component (B) is at least one selected from the group consisting of sulfates, carbonates, and hydrochlorides.
<7> The antiperspirant composition according to any one of <2> to <6>, wherein the component (C) is at least one selected from the group consisting of (acrylates/diacetoneacrylamide) copolymer AMP, (acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide) copolymer, and (vinyl methyl ether/ethyl maleate) copolymer.

The antiperspirant composition of the present invention has excellent antiperspirant effects and does not cause a tight feeling on the skin, and further has a good appearance, so it can be used widely in cosmetics, pharmaceuticals, quasi-drugs, etc., and can be preferably used in antiperspirants, deodorants, antiperspirant deodorants, and deodorants.

Claims (6)

(A) at least one antiperspirant component selected from aluminum halides, aluminum halide hydrates, and aluminum halide hydrate complexes;
(B) a water-soluble inorganic salt other than an aluminum salt having at least one counter ion selected from an alkali metal ion, a barium ion, and a magnesium ion;
(C) a copolymer or a salt thereof, comprising, as a monomer unit, at least one selected from the group consisting of monoalkyl maleate having an alkyl group with 1 to 4 carbon atoms, alkylacrylamide having an alkyl group with 1 to 8 carbon atoms, diacetoneacrylamide, vinylpyrrolidone, and ethyl betaine methacrylate;
(G) ethanol;
Contains
An antiperspirant composition, characterized in that the mass ratio (A)/(B) of the content of the component (A) to the content of the component (B) is 5 to 20. (E) Hydrophobized alkyl-modified alkyl cellulose, and
(F) at least one selected from bis-ethoxydiglycol succinate and bis-ethoxydiglycol cyclohexanedicarboxylate,
2. The antiperspirant composition of claim 1 further comprising: 3. The antiperspirant composition according to claim 2, wherein the mass ratio (B)/(E) of the content of the component (B) to the content of the component (E) is 2.1 to 10. 4. The antiperspirant composition according to claim 1, further comprising (D) a hydroxyalkylated cyclodextrin. 5. The antiperspirant composition according to claim 1, wherein the component (B) is at least one selected from the group consisting of sulfates, carbonates, and hydrochlorides. 6. The antiperspirant composition according to any one of claims 1 to 5, wherein the component (C) is at least one selected from the group consisting of an acrylates/diacetoneacrylamide copolymer or a salt thereof, an acrylates/alkyl (C1-18) acrylate/alkyl (C1-8) acrylamide copolymer or a salt thereof, and a vinyl methyl ether/ethyl maleate copolymer.