JP7464628B2 - Cooling composition and method for spraying a cooling composition using a thermally actuated microfluidic cartridge - Patents.com - Google Patents

Description

The present invention is directed to a cooling composition and a method for spraying the cooling composition from a thermally actuated microfluidic cartridge.

Recently, attempts have been made to use thermally actuated microfluidic devices to deliver fluid compositions, such as cooling compositions including fragrance mixtures, into the air. Such thermally actuated microfluidic devices may include a microfluidic die having multiple nozzles for dispensing the fluid compositions. One problem with thermally actuated microfluidic dies is clogging of the nozzles after repeated use of the microfluidic delivery system. When the nozzles become clogged, it may be difficult or impossible for a user to clear the blockage. As a result, the flow rate of the fluid composition flowing out of the microfluidic delivery system may decrease over time, resulting in a decrease in the flow rate of the dispensed fluid composition or an increase in operating time to compensate for the decrease in flow rate. Thus, a need remains for a fluid composition that minimizes clogging of the nozzles of the microfluidic die.

"combination:"
A. A microfluidic cartridge releasably connectable to a housing, the cartridge comprising a reservoir for containing a fluid composition, and a microfluidic die in fluid communication with the reservoir, the composition comprising greater than 5% by weight of a solubilizing material that is liquid at 20° C., each of the solubilizing materials being:
A polar parameter (δp) in the Hansen solubility parameters of more than ^0.5 at 5 MPa;
A hydrogen bond parameter (δh) in the Hansen solubility parameters greater than ^0.5 at 9 MPa , and a vapor pressure measured at 25° C. of less than 267 Pa;
A cartridge, wherein the composition comprises less than 22% by weight of benzyl alcohol.

B. A cartridge as described in paragraph A, wherein the composition comprises 5% to 25% by weight of the solubilizing material based on the weight of the total composition.

C. A cartridge as described in paragraph A or B, having a vapor pressure of 134 Pa or less measured at 25°C.

D. A cartridge according to any one of paragraphs A to C, having a vapor pressure of 34 Pa or less measured at 25°C.

E. The cartridge of any of paragraphs A-D, wherein the solubilizing material is selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof.

F. A cartridge according to any of paragraphs A-E, wherein the composition comprises a ClogP of less than 3.5.

G. A method of propelling a composition, the method comprising:
Providing a composition comprising greater than 5% by weight of solubilizing materials that are liquid at 20° C., each of the solubilizing materials being:
A polar parameter (δp) in the Hansen solubility parameters of more than ^0.5 at 5 MPa;
having a hydrogen bond parameter (δh) in the Hansen solubility parameters greater than ^0.5 at 9 MPa and a vapor pressure less than 267 Pa;
heating the composition with a thermal actuator;
spraying the heated composition from a nozzle in a direction between 0 and 90 degrees relative to the direction of gravity;
A method comprising:

H. The method of paragraph G, wherein spraying the heated composition further comprises spraying the heated composition from a nozzle of a microfluidic delivery member, the microfluidic delivery member comprising a silicon semiconductor substrate including a plurality of heater resistors, at least one fluid chamber associated with each heater resistor, and at least one nozzle associated with each fluid chamber.

I. The method of paragraph G or H, wherein the composition comprises 5% to 25% by weight of the solubilizing material based on the weight of the total composition.

J. The method of any of paragraphs G to I, wherein the vapor pressure is 137 Pa or less when measured at 25°C.

K. The method of any of paragraphs G-J, wherein the polar parameter (δp) in the Hansen Solubility Parameters is greater than 7 MPa ^0.5 , the hydrogen bond parameter (δh) in the Hansen Solubility Parameters is greater than 10 MPa ^0.5 , and the vapor pressure is 34 Pa or less, measured at 25° C.

L. The method of any of paragraphs G-K, wherein the solubilizing material is selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof.

M. A microfluidic cartridge releasably connectable to a housing, the cartridge comprising a reservoir for containing a fluid composition, and a microfluidic die in fluid communication with the reservoir, the composition being: , the microfluidic die configured to dispense the fluid composition in a direction between 0 degrees and 90 degrees relative to a direction of gravity;
The fluid composition comprises greater than 5% by weight of a solubilizing material that is liquid at 20° C., each of the solubilizing materials being:
A polar parameter (δp) in the Hansen solubility parameters of more than ^0.5 at 5 MPa;
A microfluidic cartridge having a hydrogen bonding parameter (δh) in the Hansen solubility parameters greater than ^0.5 and a vapor pressure less than 267 Pa.

N. A cartridge as described in paragraph M, wherein the composition comprises 5% to 25% by weight of the solubilizing material based on the weight of the total composition.

O. A cartridge as described in paragraph M or N, having a vapor pressure of 137 Pa or less measured at 25°C.

P. The cartridge of any of paragraphs M-O, having a polar parameter (δp) in the Hansen Solubility Parameters greater than 7 MPa ^0.5 , a hydrogen bond parameter (δh) in the Hansen Solubility Parameters greater than 10 MPa ^0.5 , and a vapor pressure of 34 Pa or less measured at 25° C.

Q. The cartridge of any of paragraphs M-P, wherein the solubilizing material is selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof.

R. A microfluidic cartridge releasably connectable to a housing, the cartridge comprising a reservoir for containing a fluid composition, and a microfluidic die in fluid communication with the reservoir, the composition comprising greater than 5% by weight of a solubilizing material that is liquid at 20° C., each of the solubilizing materials being:
A polar parameter (δp) in the Hansen solubility parameters of more than ^0.5 at 5 MPa;
A hydrogen bond parameter (δh) in the Hansen solubility parameters greater than ^0.5 at 9 MPa; and a vapor pressure measured at 25° C. of less than 1.4 Pa.
A cartridge having

S. The cartridge of paragraph R, having a polar parameter (δp) in the Hansen solubility parameters greater than 7 MPa ^0.5 , a hydrogen bond parameter (δh) in the Hansen solubility parameters greater than 10 MPa ^0.5 , and a vapor pressure of 34 Pa or less measured at 25° C.

FIG. 1 is a perspective view of a microfluidic cartridge having electrical circuitry and a microfluidic die. FIG. 1 is a cross-sectional view of a microfluidic cartridge. FIG. 1 is an exploded view of the electrical circuitry and microfluidic die on a microfluidic cartridge. FIG. 2 is a cross-sectional view of a microfluidic die. FIG. 2 is a plan view of a portion of a microfluidic die. FIG. 1 is a front perspective view of a microfluidic delivery device. FIG. 2 is a perspective view of the rear of a microfluidic delivery device. FIG. 2 is a top plan view from above of a microfluidic delivery device. A rating scale for solubilizing materials in a fluid composition.

Although the following description describes a fluid composition, a microfluidic delivery device, and a method for spraying a fluid composition, each having various components, it should be understood that the fluid composition, the microfluidic delivery device, and the method for spraying a fluid composition are not limited to the configurations and arrangements set forth in the following description or illustrated in the drawings.

The fluid composition of the present invention is adapted to be ejected from a microfluidic cartridge of a microfluidic delivery device. The microfluidic delivery device of the present disclosure overcomes challenges associated with dispensing a fluid composition in a horizontal or downward direction. The microfluidic delivery device may include a housing electrically connectable to a power source and a cartridge releasably connectable to the housing. The microfluidic cartridge has a reservoir for containing the fluid composition and a microfluidic die in fluid communication with the reservoir. The microfluidic die is disposed on the microfluidic cartridge such that the fluid composition exits the microfluidic die in a direction between 0 degrees and 90 degrees relative to the direction of gravity.

Freezing of the fluid composition on the surface of the nozzle plate or within the chambers of the microfluidic die can cause clogging of one or more of the nozzles. This is especially true when the fluid exits the microfluidic die at an angle between 0 and 90 degrees to the direction of gravity, as some accumulation of fluid on the nozzle layer is virtually unavoidable given the positive forces that must be balanced for functionality.

The fluid compositions of the present invention may contain one or more solubilizing materials that are liquid at 20°C, and have a hydrogen bonding parameter in the Hansen solubility parameters greater than 9 MPa ^0.5 , a polarity parameter in the Hansen solubility parameters greater than 5 MPa ^0.5 , and a vapor pressure less than 267 Pa measured at 25°C.

The fluid composition may be configured as a cooling composition. The cooling composition may include a fragrance mixture, an odor blocking agent, a reactive aldehyde, a functional fragrance ingredient, water, an adjuvant, and combinations thereof.

Fluid Compositions Many characteristics of a fluid composition are considered to operate well within a microfluidic delivery system. Some factors include formulating a fluid composition with an optimal viscosity for ejection from a microfluidic delivery die, formulating a fluid composition with limited or no suspended solids that would clog the microfluidic delivery die, formulating a fluid composition that is stable enough so that it does not dry out and clog the microfluidic delivery member, formulating a fluid composition that is not flammable, etc. Proper atomization and effective dispensing of air-freshening or odor-reducing compositions may be considered in the design of the fluid composition for proper dispensing from the microfluidic die.

The fluid composition may exhibit a viscosity of less than 20 centipoise ("cps"), alternatively less than 18 cps, alternatively less than 16 cps, alternatively from about 3 cps to about 16 cps, alternatively from about 4 cps to about 12 cps. The fluid composition may have a surface tension of less than about 35 dynes/cm, alternatively from about 20 dynes/cm to about 30 dynes/cm. Viscosity is reported in cps as measured using an Anton Paar SVM3000 series kinematic viscometer or equivalent measuring device capable of accurately measuring the expected viscosity range of the fluid at room temperature. It may also be a combination of instruments, such as a Bohlin CVO rheometer system in conjunction with a sensitive dual gap geometry.

The fluid composition may be substantially free of suspended solids or solid particles present in a mixture in which particulate material is dispersed within a liquid matrix. The fluid composition may have less than 20% suspended solids by weight, alternatively less than 15% suspended solids by weight, alternatively less than 10% suspended solids by weight, alternatively less than 5% suspended solids by weight, alternatively less than 4% suspended solids by weight, alternatively less than 3% suspended solids by weight, alternatively less than 2% suspended solids by weight, alternatively less than 1% suspended solids by weight, alternatively less than 0.5% suspended solids by weight, or no suspended solids. Suspended solids are distinct from the dissolved materials that characterize some flavoring materials.

It is contemplated that the liquid composition may contain other volatile materials in addition to or as a substitute for the fragrance mixture, including, but not limited to, volatile dyes; compositions that function as insecticides; essential oils or materials that condition, modify, or otherwise alter the environment (e.g., to aid in sleep, wakefulness, respiratory health, and the like); deodorant or malodor control compositions (e.g., odor neutralizing materials such as reactive aldehydes (as disclosed in U.S. Patent Application Publication No. 2005/0124512), odor blocking materials, odor masking materials, or sensory modifiers such as ionones (as also disclosed in U.S. Patent Application Publication No. 2005/0124512)).

Fragrance Mixture The fluid composition may comprise a fragrance mixture present in an amount greater than about 50%, alternatively greater than about 60%, alternatively greater than about 70%, alternatively greater than about 75%, alternatively greater than about 80%, alternatively between about 50% and about 100%, alternatively between about 60% and about 100%, alternatively between about 70% and about 100%, alternatively between about 80% and about 100%, alternatively between about 90% and about 100%, based on the weight of the fluid composition.

A fragrance mixture may contain one or more fragrance raw materials. The fragrance raw materials may be selected based on the boiling point ("Boiling Point, B.P.") of the material. The boiling points referred to herein are those at normal standard pressure of 760 mmHg. The boiling points of many fragrance ingredients at standard 760 mmHg can be found in Steffen Arctander, "Perfume and Flavor Chemicals (Aroma Chemicals)" (1969). When experimentally measured boiling points of individual ingredients are not available, values can be estimated by the Boiling Point PhysChem model available from ACD/Labs, Toronto, Ontario, Canada.

The fragrance mixture may have a molar weighted average log of the octanol/water partition coefficient ("ClogP") of less than about 3.5, alternatively less than about 2.9, alternatively less than about 2.5, alternatively less than about 2.0. If experimentally measured logP of the individual components is not available, values can be estimated by the boiling point PhysChem model available from ACD/Labs (Toronto, Ontario, Canada).

It may be useful to optimize the fluid composition and/or the fragrance mixture of the fluid composition for a critical pressure and a critical temperature. The critical pressure may be optimized for the bubble formation energy process and the critical temperature for kogation tendency.

The fragrance mixture may have a molar weighted average boiling point of less than 250°C, alternatively less than 225°C, alternatively less than 200°C, alternatively less than about 150°C, or alternatively from about 150°C to about 250°C.

Alternatively, about 3% to about 25% by weight of the fragrance mixture may have a molar weighted average boiling point of less than 200°C, and alternatively about 5% to about 25% by weight of the fragrance mixture may have a molar weighted average boiling point of less than 200°C.

For purposes of this disclosure, the boiling point of a fragrance blend is determined by the molar weighted average boiling point of the individual fragrance raw materials that make up the fragrance blend. If the boiling points of the individual fragrance materials are not known from published experimental data, they are determined by the Boiling Point PhysChem model available from ACD/Labs.

Table 1 lists some non-limiting, exemplary individual fragrance materials suitable for use in fragrance blends.

Table 2 shows exemplary fragrance mixtures having a total molar weighted average B.P. ("molar weighted average boiling point") less than 200° C. In calculating the molar weighted average boiling point, as illustrated in Table 2, the boiling points of difficult to determine fragrance raw materials can be ignored if those raw materials constitute less than 15% by weight of the total fragrance mixture.

Solubilizing Materials The compositions of the present invention may contain one or more solubilizing materials that are liquid at 20° C., with a hydrogen bonding parameter in the Hansen Solubility Parameters greater than 9 MPa ^0.5 , a polarity parameter in the Hansen Solubility Parameters greater than 5 MPa ^0.5 , and a vapor pressure less than 267 Pa measured at 25° C. Without being bound by theory, it is believed that the solubilizing materials regulate the evaporation of any fluid composition deposited on the surfaces of the thermally actuated microfluidic die, thus limiting the mass transfer rate of the liquid and limiting the transition of unstable materials in the fluid to solids, thereby preventing gel formation or solidification and nozzle blockage.

In the context of this disclosure, the Hansen Solubility Parameter is defined as the square root of the cohesive energy density, δ=(E/V) ^1/2 , where V is the molar volume and E is the vaporization energy. The basis for the Hansen Solubility Parameter (HSP) is that the total energy of vaporization of a liquid is composed of several individual parts. Hansen defines three contributions to the vaporization energy: the dispersive parameter (δ _d ), the polar parameter (δ _p ), and the hydrogen bonding parameter (δ _h ). Each parameter, δ _d , δ _p , and δ _h , is typically measured in units of MPa ^0.5 .

The hydrogen bond parameter in the Hansen solubility parameters is based on the contribution of hydrogen bond cohesive energy to the evaporation energy. The polar parameter in the Hansen solubility parameters is based on the contribution of polar cohesive energy to the evaporation energy. The hydrogen bond parameter in the Hansen solubility parameters and the polar parameter in the Hansen solubility parameters can be calculated or predicted using the HSPiP software available at the following web address: https://www.hansen-solubility.com/HSPiP/ . The Sphere algorithm is described in Hansen, C. M., Hansen Solubility Parameters: A User's Handbook, CRC Press, Boca Raton FL, 2007. The Y-MB method was developed by Dr Hiroshi Yamamoto of Asahi Glass Corporation.

The HSPiP software relies on a database with data for a limited number of materials. If the HSPiP database does not have data for a substance of interest, the Hansen Solubility Parameters can be calculated using the following formula:
^Ra2 = 4(δD1-δD2) ² + (δP1-δP2) ² + (δH1-δH2) ²
RED=Ra/R0

More information about the calculations can be found at https://www.hansen-solubility.com/HSP-science/basics.php.

The composition of the present invention may comprise or consist essentially of greater than 1 wt%, greater than 5 wt%, greater than 8 wt%, greater than 10 wt%, greater than 12 wt%, greater than 15 wt%, greater than 18 wt%, or greater than 20 wt% of a solubilizer having a hydrogen bond parameter in the Hansen solubility parameters greater than 9 MPa ^0.5 , a polar parameter in the Hansen solubility parameters greater than 5 MPa ^0.5 , and a vapor pressure less than 267 Pascals (Pa) measured at 25° C. The hydrogen bond parameter in the Hansen solubility parameters may be greater than 9 MPa ^0.5 , greater than 10 MPa ^0.5 , greater than 12 MPa ^0.5 , or greater than 15 MPa ^0.5 . The polar parameter in the Hansen solubility parameters may be greater than 5 MPa ^0.5 , greater than 6 MPa ^0.5 , greater than 7 MPa ^0.5 , or greater than 8 MPa ^0.5 . The vapour pressure may be less than 267 Pa, preferably less than 137 Pa, preferably less than 67 Pa, preferably less than 34 Pa, more preferably less than 14 Pa, and more preferably less than 1.5 Pa, measured at 25°C.

The solubilizer having a hydrogen bonding parameter in the Hansen solubility parameters of greater than 9 MPa ^0.5 , a polarity parameter in the Hansen solubility parameters of greater than 5 MPa ^0.5 , and a vapor pressure measured at 25° C. of less than 267 Pa may be selected from the group consisting of:
3-Hydroxybutan-2-one (Acetyl methyl carbinol, CAS No. 513-86-0); 1-Hydroxypropan-2-one (Acetol, CAS No. 116-09-6); N,N-Dimethylacetamide (CAS No. 127-19-5); 3-Hydroxypentan-2-one (Acetyl carbinol, CAS No. 3142-66-3); Isobutyric acid (Isobutyric acid, 99% or more, FCC, CAS No. 79-31-2); 5-Hexenol (CAS No. 821-41- 0) 4-Methylpentan-1-ol (4-Methyl-1-pentanol, CAS No. 626-89-1); Ethyl 2-hydroxypropanoate (Ethyl lactate, CAS No. 97-64-3); Dimethyl malonate (CAS No. 108-59-8); (E)-Hex-3-en-1-ol (3-Hexene-1-ol, CAS No. 544-12-7); (E)-Hex-3-en-1-ol (trans-3-hexene-1-ol, CAS No. 928-97-2); Heptane-3 -ol (3-heptanol, 98% or more, CAS No. 589-82-2); 2-mercaptoethan-1-ol (2-hydroxyethanethiol, CAS No. 60-24-2); furan-2-ylmethanol (furfuryl alcohol, CAS No. 98-00-0); 2-oxopropanoic acid (pyruvic acid BRI, CAS No. 127-17-3); 1,5 diaminopentane (CAS No. 462-94-2); hexan-1-ol (hexanol, CAS No. 111-27-3 ); (E)-Hex-4-en-1-ol (trans-4-hexenol, CAS No. 6126-50-7); Heptan-2-ol (2-heptanol, 97% or more, CAS No. 543-49-7); (E)-Hex-2-en-1-ol (trans-2-hexenol, CAS No. 2305-21-7); (Z)-Hex-2-en-1-ol (cis-2-hexen-1-ol, CAS No. 928-94-9); 1-Amino-2-propanol (CAS No. 7 8-96-6); methyl furan-2-carboxylate (methyl 2-furoate, CAS No. 611-13-2); 1-hydroxybutan-2-one (1-hydroxy-2-butanone, CAS No. 5077-67-8); 3-(methylthio)hexan-1-ol (3-(methylthio)-1-hexanol, 97% or more, CAS No. 51755-66-9); methyl sulfoxide, 99% or more (CAS No. 67-68-5); 3-mercaptobutan-2-ol (2-mercaptobutan-2-ol, CAS No. 67-68-5); Capto-3-butanol, mixture of isomers, 97% or more, FG, CAS No. 37887-04-0); 3-methyl-2-oxobutanoic acid (dimethylpyruvic acid, CAS No. 759-05-7); 3-methoxy-3-methylbutan-1-ol (3-methoxy-3-methyl-1-butanol, CAS No. 56539-66-3); (5-methylfuran-2-yl)methanol (5-methylfurfuryl alcohol, CAS No. 3857-25-8); 2,4-dimethyl-2-pentanol (5-methylfuran-2-yl)methanol (5-methylfurfuryl alcohol, CAS No. 3857-25-8); 2-methylbutanoic acid (Methyl-2-butyric acid NAT, CAS No. 116-53-0); 2-butoxyethan-1-ol (2-butoxyethanol, CAS No. 111-76-2); 4-hydroxy-4-methylpentan-2-one (4-hydroxy-4-methyl-2-pentanone, CAS No. 123-42-2); Ethyl 2-hydroxy-2-methylbutanoate (Ethyl 2-hydroxy-2-methylbutyrate, CAS No. 77 -70-3); 2-(methylthio)ethan-1-ol (2-(methylthio)ethanol, CAS No. 5271-38-5); 2-oxobutanoic acid (2-oxobutyric acid, 97% or more, CAS No. 600-18-0); 3-methylcyclohexanol (CAS No. 591-23-1); 2-methylcyclohexanol (CAS No. 583-59-5); 3-(ethylthio)propan-1-ol (3-ethylthiopropanol, CAS No. 18721-61-4); 2-hydroxy Propyl cypropanoate (Propyl lactate, CAS No. 616-09-1); (E)-hept-4-en-1-ol (cis-4-hepten-1-ol, CAS No. 6191-71-5); Thiophene-2-carbaldehyde (2-thiophenecarbaldehyde, CAS No. 98-03-3); Ethyl 3-hydroxybutanoate (Ethyl-3-hydroxybutyrate, CAS No. 5405-41-4); 2-hydroxybenzaldehyde (Salicylaldehyde, 98% or more, CAS No. S No. 90-02-8); (Tetrahydrofuran-2-yl)methanol (Tetrahydrofurfuryl alcohol, 98% or more, CAS No. 97-99-4); Heptan-1-ol (Heptyl alcohol, 97% or more, FCC, CAS No. 111-70-6); (2E,4Z)-Hexa-2,4-dien-1-ol (2,4-Hexadien-1-ol (sorbic alcohol), CAS No. 111-28-4); (2E,4Z)-Hexa-2,4-dien-1-ol (Tetrahydrofuran-2-yl)methanol (Tetrahydrofurfuryl alcohol, 98% or more, CAS No. 97-99-4); Heptan-1-ol (Heptyl alcohol, 97% or more, FCC, CAS No. 111-70-6); trans,trans-2,4-hexadiene-1-ol, 97% or higher, CAS No. 17102-64-6); furan-2(5H)-one (2(5H)-furanone, CAS No. 497-23-4); 2,3-butanediol (CAS No. 513-85-9); methyl 2-hydroxy-4-methylpentanoate (methyl 2-hydroxy-4-methylvalerate, CAS No. 40348-72-9); 2-(ethylthio)ethan-1-ol (ethyl 2-hydroxyethylsulfate, CAS No. 40348-72-9); 1,2-Propylene glycol, CAS No. 57-55-6; 1,2-Propylene glycol, CAS No. 57-55-6; Formamide, CAS No. 75-12-7; 2-Ethyl butanoic acid, CAS No. 88-09-5; 2-Methyl pentanoic acid, CAS No. 97-61-0; 2-Methoxy phenol, CAS No. 97-61-0; (Guaiacol, natural, 98% or more, FG, CAS No. 90-05-1); (S)-3-(ethylthio)butan-1-ol (3-(ethylthio)butanol, CAS No. 117013-33-9); (S)-3-hydroxyoctan-2-one (3-hydroxy-2-octanone, CAS No. 37160-77-3); 1-(thiophen-2-yl)ethan-1-one (2-acetylthiophene, CAS No. 88-15-3); 4-(methylthio)butan-1-ol 4-methylthiobutanol (4-methylthiobutanol, CAS No. 20582-85-8); 2-(methylthio)phenol (O-(methylthio)phenol, CAS No. 1073-29-6); phenylmethanol (benzyl alcohol, CAS No. 100-51-6); 3-(methylthio)propan-1-ol (3-(methylthio)-1-propanol, 98% or more, FG, CAS No. 505-10-2); 2-hydroxypropanoic acid butyl (butyl(S)-(-)-lactic acid, 97% or more, C 3-Methylpentanoic acid (3-Methylpentanoic acid, CAS No. 105-43-1); Butylamide (Butylamide, CAS No. 541-35-5); (E)-2-Methylpent-3-enoic acid (2-Methyl-3-pentenoic acid , CAS No. 37674-63-8); 1-phenylethan-1-ol (α-methylbenzyl alcohol, 99% or more, FCC, CAS No. 98-85-1); 2,4-dimethylphenol (CAS No. 105-67-9); 1-(2,4-dimethyl-1,3-dioxolan-2-yl)ethan-1-ol (acetoin propylene glycol acetal, CAS No. 94089-23-3); 2-mercapto-2-methylpentan-1-ol (Tropicol, 0.1% IPM, CAS No. 258823-39-1); 2-(2-methoxyethoxy)ethan-1-ol (methyl carbitol, CAS No. 111-77-3); octan-1-ol (octyl alcohol, CAS No. 111-87-5); ethyl (±)-2-hydroxycaproate, 97% or higher (CAS No. 52089-55-1); (E)-pent-2-enoic acid (2-pentenoic acid, CAS No. 13991-37-2); 2-mercaptopropanoic acid (2-mercaptopropioic acid acid, 95% or more, CAS No. 79-42-5); ethyl (2R,3S)-2-hydroxy-3-methylpentanoate ((+/-)-ethyl-2-hydroxy-3-methylvalerate, CAS No. 24323-38-4); 2-methylpentane-2,4-diol (hexylene glycol, CAS No. 107-41-5); (S)-4-mercapto-4-methylpentan-2-ol (4-mercapto-4-methyl-2-pentanol, CAS No. 31539-84-1); 1-(p-tolyl)ethan-1-ol (a,p-dimethylbenzyl alcohol, CAS number 536-50-5); (E)-hex-3-enoic acid (trans-3-hexenoic acid, 98% or more, CAS number 1577-18-0); (Z)-hex-3-enoic acid (cis-3-hexenoic acid BRI (natural), CAS number 1775-43-5); 2-methoxy-4-methylphenol (2-methoxy-4-methylphenol, 98% or more, FG, CAS number 93-51-6); 2-(2- ethoxyethoxy)ethan-1-ol (diethylene glycol monoethyl ether, CAS No. 111-90-0); isopentyl 2-hydroxypropanoate (isoamyl lactate, CAS No. 19329-89-6); methyl 2-hydroxybenzoate (methyl salicylate, USP, CAS No. 119-36-8); 1-(2-methoxypropoxy)propan-2-ol (dipropylene glycol methyl ether, CAS No. 34590-94-8); heptanoic acid (heptanoic acid, CAS No. 111-14-8); dimethyl sulfone (CAS No. 67-71-0); (Z)-2-methylpent-2-enoic acid (Strawberiff, CAS No. 3142-72-1); (E)-4-methylpent-2-enoic acid (4-methyl-2-pentenoic acid, CAS No. 10321-71-8); 2,4-dimethyl-2-pentenoic acid (CAS No. 66634-97-7); 2-(ethoxymethyl)phenol (α-ethoxy-ortho-cresol, CAS No. 20920- 83-6); 3-mercaptopropanoic acid (3-mercaptopropionic acid, CAS No. 107-96-0); 2-hydroxybenzoic acid ethyl (ethyl salicylate, CAS No. 118-61-6); mercaptoacetic acid (CAS No. 68-11-1); 2-pyrrolidone (CAS No. 616-45-5); 3-phenylpropan-1-ol (phenylpropyl alcohol, CAS No. 122-97-4); 2-hydroxypropanoic acid hexyl (lactate hexyl, CAS No. 20279-5 1-0); 1-(2-aminophenyl)ethan-1-one (2-aminoacetophenone, CAS No. 551-93-9); 3-hydroxyhexanoic acid methyl (3-hydroxyhexanoic acid methyl, 97% or more, FG, CAS No. 21188-58-9); 3-methoxyphenol (3-methoxyphenol, CAS No. 150-19-6); 2-methoxy-4-vinylphenol (2-methoxy-4-vinylphenol, 98% or more, CAS No. 7786-61-0); 4-ethyl 2-(o-tolyl)ethan-1-ol (Peomosa, CAS No. 19819-98-8); 2-(m-tolyl)ethan-1-ol (3-methylphenethyl alcohol, CAS No. 1875-89-4); 3-(hydroxymethyl)heptan-2-one (3-octanon-1-ol, CAS No. 65405-68-7); 2-phenoxyethane-
1-ol (2-phenoxyethanol, CAS No. 122-99-6); lactic acid (CAS No. 50-21-5); 2-allyl-6-methoxyphenol (ortho-eugenol, CAS No. 579-60-2); 5-ethyl-4-hydroxy-2-methylfuran-3(2H)-one (2-ethyl-4-hydroxy-5-methyl-3(2H)furanone, 20% in PG, CAS No. 27538-09-6); 2-ethyl-4-hydroxy-5-methylfuran-3(2H)-one (homofuraneol pure, 100% undiluted, CAS No. 27538-09-6); (Z)-oct-5-enoic acid ((Z)-5-octenoic acid, CAS No. 41653-97-8); 4-oxopentanoic acid (levulinic acid, 97% or more, FG, CAS No. 123-76-2); 4-allyl-2-methoxyphenol (eugenol, CAS No. 97-53-0); 3-(methylthio)propanoic acid (3-methylthiopropionic acid, CAS No. 646-01-5); (4-methoxyphenyl)methanol (anisyl alcohol, CAS No. 105-13-5); 3-hydroxypropane-1,2-diyl diacetate (diacetin, CAS No. 25395-31-7); 2-methoxy-4-propylphenol (dihydroeugenol, CAS No. 2785-87- 7); ethyl 3-hydroxyhexanoate (ethyl 3-hydroxyhexanoate, CAS No. 2305-25-1); 1-((1-propoxypropan-2-yl)oxy)propan-2-ol (dipropylene glycol n-propyl ether, CAS No. 29911-27-1); (Z)-2-methoxy-4-(prop-1-en-1-yl)phenol ((E)-isoeugenol, CAS No. 5932-68-3); (E)-2-methoxy-4-(prop-1-en-1-yl)phenol (cis-isoeugenol, CAS No. 5912-86-7); (S)-3-(hydroxymethyl)octane-2- ion (hydroxymethylhexyl ethyl ketone, CAS No. 59191-78-5); 2,2'-oxybis(ethan-1-ol) (diethylene glycol, CAS No. 111-46-6); 4-(methylthio)-2-oxobutanoic acid (4-(methylthio)-2-oxobutyric acid, CAS No. 583-92-6); N-methyldiethanolamine (N-methyldiethanolamine, CAS No. 105-59-9); (E)-hex-3-en-1-yl 2-hydroxypropanoic acid (cis-3-hexenyl lactate, CAS No. 61931-81-5); 2-ethoxy-4-(methoxymethyl)phenol (Methyl Diantilis®, CAS No. 5595-79-9); 4-(ethoxymethyl)-2-methoxyphenol (vanillyl ethyl ether, CAS No. 13184-86-6); 2-(4-methylthiazol-5-yl)ethan-1-ol (sulfurol, CAS No. 137-00-8); (R)-3-hydroxy-4-phenylbutan-2-one (3-hydroxy-4-phenyl-2-butanone, CAS No. 5355-63-5); 3-ethyl-2-hydroxycyclopent-2-en-1-one (ethylcyclopentelone, pure, CAS No. 21835-01-8); 2-hydroxypropanol benzyl lactate (benzyl lactate, CAS No. 2051-96-9); 5-ethyl-2-hydroxy-3-methylcyclopent-2-en-1-one (5-ethyl-3-methylcyclotene, CAS No. 53263-58-4); 3-ethyl-2-hydroxy-4-methylcyclopent-2-en-1-one (3-ethyl-4-methylcyclotene, CAS No. 42348-12-9); 2-hydroxy-3,5,5-trimethylcyclohex-2-en-1-one (2-hydroxy-3,5,5-trimethyl-2-cyclohexenone, CAS No. 4883-60-7); dipropylene glycol-N-butyl ether 3-(hydroxymethyl)nonan-2-one (3-(hydroxymethyl)-2-nonanone, CAS No. 67801-33-6); 3,7-dimethyloctane-1,7-diol (hydroxyol, CAS No. 107-74-4); 2-(2-hydroxypropan-2-yl)-5-methylcyclohexan-1-ol (geranodyl, CAS No. 42822-86-6); 4-hydroxybenzoic acid propyl (p-hydroxybenzoic acid propyl, CAS No. 94-13-3); 5-(hydroxymethyl)furan-2-carbaldehyde (5-(hydroxymethyl)furan-2-carbaldehyde, CAS No. 107-74-4); furfural, 99% or more, CAS No. 67-47-0); ethyl 4-hydroxybenzoate (ethyl p-hydroxybenzoate, CAS No. 120-47-8); 4-propylsyringol (CAS No. 6766-82-1); 4-allyl-2,6-dimethoxyphenol (4-allyl-2,6-dimethoxyphenol, 90% or more, CAS No. 6627-88-9); 3-hydroxyethyl octanoate (CAS No. 7367-90-0); diethyl 2,3-dihydroxysuccinate (diethyl L-tartrate, 99% or more, CAS No. 87-91-2); diethyl 2-hydroxysuccinate (diethyl malate 626-11-9); triethylene glycol (CAS No. 112-27-6); (2S,3R)-3-(((2S,3R)-3-mercaptobutan-2-yl)thio)butan-2-ol (a-methyl-b-hydroxypropyl-a-methyl-b-mercaptopropyl sulfide, CAS No. 54957-02-7); (2-phenyl-1,3-dioxolan-4-yl)methanol (benzaldehyde glyceryl acetal, CAS No. 1319-88-6); ethyl 3-hydroxy-3-phenylpropanoate (ethyl 3-hydroxy-3-phenylpropionate, CAS No. 5764-8 5-2); 1-(heptyloxy)-3-hydroxypropan-2-one (heptanol glyceryl acetal, CAS No. 72854-42-3); 3-hydroxypropanoic acid phenethyl (phenylethyl lactate, CAS No. 10138-63-3); 2-methoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (vanillin propylene glycol acetal, 68527-74-2); 3-hydroxy-4,5-dimethylfuran-2(5H)-one (caramelfuranone (3% in triacetin), CAS No. 28664-35-9); 5-ethyl-3-hydroxy-4-methylfuran-2 (5H)-one (Maple furanone (undiluted), CAS No. 698-10-2); 2-ethoxy-4-(4-methyl-1,3-dioxolan-2-yl)phenol (Ethyl vanillin propylene glycol acetal, CAS No. 68527-76-4); 2-hydroxy-1,2-diphenylethan-1-one (Benzoin, CAS No. 119-53-9); 3-((2-isopropyl-5-methylcyclohexyl)oxy)propane-1,2-diol (3-1-menthoxypropane-1,2-diol, CAS No. 87061-04-9); (R)-2-hydroxy-N-(2-hydroxyethyl)propane lopanamide (lactoylethanolamine, CAS No. 5422-34-4); 2,3-dihydroxypropyl 5-hydroxydecanoate (glyceryl 5-hydroxydecanoate, CAS No. 26446-31-1); 1-hydroxy-4-methyl-2-pentanone (1-hydroxy-4-methyl-2-pentanone, CAS No. 68113-55-3); 2-(2-hydroxypropoxy)propan-1-ol (dipropylene glycol, CAS No. 25265-71-8); 2-phenylethan-1-ol (phenylethyl alcohol, CAS No. 60-12-8); and combinations thereof.

The solubilizer having a hydrogen bonding parameter in the Hansen solubility parameters greater than ^0.5 at 9 MPa , a polarity parameter in the Hansen solubility parameters greater than ^0.5 at 5 MPa, and a vapor pressure less than 267 Pa when measured at 25° C. may be selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof.

Secondary Solubilizers In addition to the solubilizing materials disclosed above, the fluid composition may contain one or more secondary solubilizing agents, such as, for example, polyols (components containing two or more hydroxyl functional groups), glycol ethers, or polyethers. If the secondary solubilizing agent present in the fluid composition falls within the Hansen solubility parameters and vapor pressure of the solubilizing material, the secondary solubilizing agent should be considered as falling within the total weight percent of the solubilizing material in the cooling composition.

Exemplary oxygenated solvents, including polyols, include ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, and/or glycerin. The polyols used in the cooling compositions of the present invention can be, for example, glycerin, ethylene glycol, propylene glycol, dipropylene glycol.

Exemplary oxygenated solvents that include polyethers are polyethylene glycol and polypropylene glycol.

Exemplary oxygenated solvents including glycol ethers are propylene glycol methyl ether, propylene glycol phenyl ether, propylene glycol methyl ether acetate, propylene glycol n-butyl ether, dipropylene glycol n-butyl ether, dipropylene glycol n-propyl ether, ethylene glycol phenyl ether, diethylene glycol n-butyl ether, dipropylene glycol n-butyl ether, diethylene glycol monobutyl ether, dipropylene glycol methyl ether, tripropylene glycol methyl ether, tripropylene glycol n-butyl ether, other glycol ethers, or mixtures thereof. The oxygenated solvent may be ethylene glycol, propylene glycol, or mixtures thereof. The glycol used may be dipropylene glycol.

The oxygenated solvent may be added to the composition at a level of about 0.01% to about 50% by weight based on the weight of the composition, alternatively about 0.01% to about 20% by weight based on the weight of the composition, alternatively about 0.05% to about 10% by weight based on the weight of the total composition, alternatively about 0.1% to about 5% by weight.

Water The fluid composition may comprise water. The fluid composition may comprise water in an amount of about 0.25% to about 20% by weight, alternatively about 0.25% to about 10% by weight, alternatively about 1% to about 5% by weight, alternatively about 1% to about 3% by weight, alternatively about 1% to about 2% by weight, based on the weight of the fluid composition. Without being bound by theory, it has been found that water may be incorporated into the fluid composition at a concentration of about 0.25% to about 9.5% by weight, alternatively about 0.25% to about 7.0% by weight, based on the weight of the entire composition, by formulating the perfume mixture to have a molar weighted average ClogP of less than about 2.5.

Malodor Blockers The fluid composition may include one or more malodor blockers that dull the human olfactory sensor, but do not overly interfere with the aroma of the liquid composition. Exemplary malodor blockers may be selected from the group consisting of: 1,1,2,3,3-pentamethyl-1,2,3,5,6,7-hexahydro-4H-inden-4-one (Cashmeran, 33704-61-9); 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yl acetate furol (acetate/herbafurolate, CAS No. 5413-60-5). 1-((2-(tert-butyl)cyclohexyl)oxy)butan-2-ol (Ambercore, CAS No. 139504-68-0); 2-(8-isopropyl-6-methylbicyclo[2.2.2]oct-5-en-2-yl)-1,3-dioxolane (Glycolieral/Flicoacetal, CAS No. 68901-32-6); (E)-Oxacyclohexadec-13-en-2-one (Habanolide, CAS No. 111879-80-2); (Z)-cyclooct-4-en-1-yl methyl carbonate (Violiff, CAS No. 87731-18-8); 7-methyloctyl acetate (isononyl acetate, CAS No. 40379-24-6); ethyl dodecanoate (ethyl laurate, CAS No. 106-33-2); 4,5-epoxy-4,11,11-trimethylol acetate (ethyl laurate, CAS No. 106-33-2); Methyl-8-methylenebicyclo(7.2.0)undecane (caryophyllene oxide, CAS number 1139-30-6); 1,3,4,6,7,8α-hexahydro-1,1,5,5-tetramethyl-2H-2,4α-methanophthalen-8(5H)-one (isolongifolanone, CAS number 23787-90-8); dodecan-1-ol (1-dodecanol, CAS number 112-53-8); 8,8- Dimethyl-3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-ylpropionate (Fultene, CAS No. 76842-49-4); (Z)-non-6-en-1-ol (cis-6-nonen-1-ol, FCC, CAS No. 35854-86-5); dodecanenitrile (Clonal, CAS No. 2437-25-4); (E)-dec-4-enal (Decenal (Triphenyl) lance-4), CAS No. 65405-70-1); (1-methyl-2-((1,2,2-trimethylbicyclo[3.1.0]hexan-3-yl)methyl)cyclopropyl)methanol (Javanol, CAS No. 198404-98-7); (E)-1,1-dimethoxy-3,7-dimethylocta-2,6-diene (Citral dimethyl acetal, CAS No. 7549-37-3); 2,6-di- tert-Butyl-4-methylphenol (BHT, CAS No. 128-37-0); oxydibenzene, (diphenyl oxide, CAS No. 101-84-8); (E)-3,7-dimethylocta-2,6-dien-1-yl palmitate (hexalose, 3681-73-0); 3-methyl-5-phenylpentan-1-ol (phenylhexanol, CAS No. 55066-48-3); 3-( 3,3-Dimethyl-2,3-dihydro-1H-inden-5-yl)propanal (Hivernal, CAS No. 173445-65-3); 3-(1,1-Dimethyl-2,3-dihydro-1H-inden-5-yl)propanal (Hivernal, CAS No. 300371-33-9); 2,2,6,6,7,8,8-Heptamethyldecahydro-2H-indeno[4,5-b]furan (Amber x-treme, CAS No. 476332-65-7); (R,Z)-1-(2,6,6-trimethylcyclohex-2-en-1-yl)pent-1-en-3-one (alpha methyl ionone, CAS No. 127-42-4); 3-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)-2,2-dimethylpropanal (vinyl isobutyraldehyde alpha, CAS No. 33885-52-8); (E)-3,7-dimethylocta-1,3,6 -triene (cis-ocimene, CAS No. 3338-55-4); 1-(5,5-dimethylcyclohex-1-en-1-yl)pent-4-en-1-one (neobutanone alpha, CAS No. 56973-85-4); (E)-cyclohexadec-5-en-1-one (5-cyclohexadecen-1-one, CAS No. 37609-25-9); 2-isopropyl-5-methylphenol (thymol, CAS No. 89-83-8); and combinations thereof.

The fluid composition may contain up to 2% by weight of the odor blocking agent, or 0.0001% to 2% by weight of the odor blocking agent, based on the total weight of the fluid composition.

Reactive Aldehydes The fluid composition may include one or more reactive aldehydes that neutralize malodors in the vapor and/or liquid phases through a chemical reaction. The reactive aldehydes provide pure malodor neutralization and not merely masking or obscuring the odor. Pure malodor neutralization provides a sensory and analytically measurable (e.g., measurable by gas chromatography) reduction in malodor.

Reactive aldehydes can react with amine-based odorants following a Schiff base formation pathway. Volatile aldehydes can also react with sulfur-based odorants to form thiol acetals, hemithiol acetals, and thiol esters in the vapor and/or liquid phase. It may be desirable for these reactive aldehydes in the vapor and/or liquid phase not to substantially adversely affect the desired perfume characteristics of the product. Aldehydes that are partially volatile may be considered reactive aldehydes as used herein.

Suitable reactive aldehydes may have a vapor pressure (VP) measured at 25°C in the range of about 0.0001 Torr to 100 Torr, alternatively about 0.0001 Torr to about 10 Torr, alternatively about 0.001 Torr to about 50 Torr, alternatively about 0.001 Torr to about 20 Torr, alternatively about 0.001 Torr to about 0.100 Torr, alternatively about 0.001 Torr to about 0.06 Torr, alternatively about 0.001 Torr to about 0.03 Torr, alternatively about 0.005 Torr to about 20 Torr, alternatively about 0.01 Torr to about 20 Torr, alternatively about 0.01 Torr to about 15 Torr, alternatively about 0.01 Torr to about 10 Torr, alternatively about 0.05 Torr to about 10 Torr.

Reactive aldehydes may also have a particular boiling point (B.P.) and octanol/water partition coefficient (P). Boiling points referred to herein are measured at normal standard pressure of 760 mmHg. Standard 760 mmHg boiling points of many reactive aldehydes are given, for example, in Steffen Arctander's Perfume and Flavor Chemicals (Aroma Chemicals), published in 1969.

The octanol/water partition coefficient of a reactive aldehyde is the ratio of its equilibrium concentrations in octanol and in water. The partition coefficients of reactive aldehydes used in the fluid composition can be more conveniently presented in the form of their logarithm to the base 10, logP. LogP values for many reactive aldehydes have been reported. See, for example, the Pomona92 database available from Daylight Chemical Information Systems, Inc. (Daylight CIS), Irvine, Calif. However, logP values are most conveniently calculated by the "CLOGP" program, also available from Daylight CIS. This program also lists experimental logP values when they are available in the Pomona92 database. The "calculated logP" (ClogP value) is determined by the fragmentation technique of Hansch and Leo (see A. Leo's article in Comprehensive Medicinal Chemistry, Vol. 4, p. 295, edited by C. Hansch, P. G. Sammens, J. B. Taylor, and C. A. Ramsden, Pergamon Press, 1990). This fragmentation technique is based on the chemical structure of each reactive aldehyde, taking into account the number and type of atoms, the connectivity of atoms, and chemical bonds. The ClogP value is the most reliable and widely used in the evaluation of this physicochemical property, and is used instead of the experimental logP value in the selection of reactive aldehydes for fluid compositions.

The ClogP values can be defined by four groups, and the reactive aldehydes can be selected from one or more of these groups. The first group includes reactive aldehydes having a boiling point of about 250° C. or less and a ClogP of about 3 or less. The second group includes reactive aldehydes having a boiling point of 250° C. or less and a ClogP of 3.0 or greater. The third group includes reactive aldehydes having a boiling point of 250° C. or more and a ClogP of 3.0 or less. The fourth group includes reactive aldehydes having a boiling point of 250° C. or more and a ClogP of 3.0 or greater. The fluid composition may include any combination of reactive aldehydes from one or more ClogP groups.

The fluid composition of the present invention may comprise, based on the total weight of the fluid composition, about 0% to about 30%, alternatively about 25%, of a reactive aldehyde from the first group, and/or about 0% to about 10%, alternatively about 10%, of a reactive aldehyde from the second group, and/or about 10% to about 30%, alternatively about 30%, of a reactive aldehyde from the third group, and/or about 35% to about 60%, alternatively about 35%, of a reactive aldehyde from the fourth group.

Exemplary reactive aldehydes that may be used in the fluid compositions of the present invention include adoxal (2,6,10-trimethyl-9-undecenal), bourgeonal (4-t-butylbenzenepropionaldehyde), Lyrestralis 33 (2-methyl-4-t-butylphenyl)propanal), cinnamic aldehyde, cinnamaldehyde (phenylpropenal, 3-phenyl-2-propenal), citral, geranial, neral (dimethyloctadienal , 3,7-dimethyl-2,6-octadien-1-al), cyclal C (2,4-dimethyl-3-cyclohexene-1-carbaldehyde), furohydral (3-(3-isopropyl-phenyl)-butyraldehyde), citronellal (3,7-dimethyl-6-octenal), cymal, cyclamen aldehyde, cyclozal, lime aldehyde (α-methyl-p-isopropylphenylpropyl aldehyde), methylnonylacetaldehyde, aldehyde C12 MNA (2-methyl-1-undecanal), hydroxycitronellal, citronellal hydrate (7-hydroxy-3,7-dimethyloctan-1-al), helional (α-methyl-3,4-(methylenedioxy)-hydrocinnamaldehyde, hydrocinnamaldehyde (3-phenylpropanal, 3-phenylpropionaldehyde), intrelevenaldehyde (undecan-10-en-1-al), ligustral, trivertal (2,4-dimethyl-3-cyclohexene-1-carboxaldehyde), Jasmorange, satinaldehyde (2-methyl-3-tolylpropionaldehyde, 4-dimethylbenzenepropanal), lyral (4-(4-hydroxy-4-methylpentyl) -3-cyclohexene-1-carboxaldehyde), Melonal (2,6-dimethyl-5-heptenal), Methoxymelonal (6-methoxy-2,6-dimethylheptanal), Methoxycinnamaldehyde (trans-4-methoxycinnamaldehyde), Miracaldehyde isohexenylcyclohexenyl-carboxaldehyde, Triphenal (3-methyl-4-phenylpropanal, 3-phenylbutanal), Lilial, P.T. Bucinal, Lysmelal, Benzenepropanal (4-tert-butyl-alpha-methyl-hydrocinnamaldehyde), Dupical, Tricyclodecylidenebutanal (4-tricyclodecylidene-2,6-decylidene-8 butanal), Melafreil (1 , 2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde), methyl octyl acetaldehyde, aldehyde C-11 MOA (2-methyldec-1-al), onicidal (2,6,10-trimethyl-5,9-undecadien-1-al), citronellyloxyacetaldehyde, muguetaldehyde 50 (3,7-dimethyl-6-octenyl)oxyacetaldehyde), phenylacetaldehyde, mefuranal (3-methyl-5-phenylpentanal), triplal, vertocitral dimethyltetrahydrobenzenealdehyde (2,4-dimethyl-3-cyclohexene-1-carboxaldehyde), 2-phenylpropionaldehyde, hydrotropaldehyde, Examples include, but are not limited to, anisylpropanal, 4-methoxy-alpha-methylbenzenepropanal (2-anisylidenepropanal), cyclemone A (1,2,3,4,5,6,7,8-octahydro-8,8-dimethyl-2-naphthaldehyde), precyclemone B (1-cyclohexene-1-carboxaldehyde); pinylisobutyraldehyde alpha (3-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)-2,2-dimethylpropanal; and hibernal (3-(3,3-dimethyl-2,3-dihydro-1H-inden-5-yl)propanal/3-(1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)propanal).

Other representative aldehydes include acetaldehyde (ethanal), pentanal, valeraldehyde, amylaldehyde, centenal (octahydro-5-methoxy-4,7-methano-1H-indene-2-carboxaldehyde), propionaldehyde (propanal), cyclocitral, beta-cyclocitral (2,6,6-trimethyl-1-cyclohexene-1-acetaldehyde), isocyclocitral (2,4,6-trimethyl-3-cyclohexene-1-carboxaldehyde), isobutyraldehyde, butyraldehyde, isovaleraldehyde (3-methylbutyraldehyde), methylbutyraldehyde (2-methylbutyraldehyde, 2-methylbutanal), dihydrocitronellal (3,7-dimethyloctan-1-al), 2-ethylbutyraldehyde, 3-methyl-2-butenal, and 2-methylpentanal. , 2-methylvaleraldehyde, hexenal (2-hexenal, trans-2-hexenal), heptanal, octanal, nonanal, decanal, lauric aldehyde, tridecanal, 2-dodecanal, methylthiobutanal, glutaraldehyde, pentanediol, glutaraldehyde, heptenal, cis or trans-heptenal, undecenal (2-, 10-), 2,4-octadienal, nonenal aldehyde (2-, 6-), decenal (2-, 4-), 2,4-hexadienal, 2,4-decadienal, 2,6-nonadienal, octenal, 2,6-dimethyl-5-heptenal, 2-isopropyl-5-methyl-2-hexenal, triphenal, beta-methylbenzenepropanal, 2,6,6-trimethyl-1-cyclohexene-1-acetaldehyde, phenylbutenal (2-phenyl-2-butenal), 2. Methyl-3(p-isopropylphenyl)-propionaldehyde, 3-(p-isopropylphenyl)-propionaldehyde, p-tolylacetaldehyde (4-methylphenylacetaldehyde), anisaldehyde (p-methoxybenzenealdehyde), benzaldehyde, vernaldehyde (1-methyl-4-(4-methylpentyl)-3-cyclohexenecarbaldehyde), heliotropin (piperonal) 3,4-methylenedioxybenzaldehyde, alpha-amylcinnamic aldehyde, 2-pentyl-3-phenyl Propene aldehyde, vanillin (4-methoxy 3-hydroxybenzaldehyde), ethyl vanillin (3-ethoxy 4-hydroxybenzaldehyde), hexyl cinnamic aldehyde, jasmonal H (alpha-n-hexyl-cinnamaldehyde), floral ozone (para-ethyl-alpha, alpha-dimethylhydrocinnamaldehyde), achalea (p-methyl-alpha-pentylcinnamaldehyde), methyl cinnamaldehyde, alpha-methyl cinnamaldehyde (2-methyl 3-phenylpropenal), al P-Hexylcinnamaldehyde (2-hexyl 3-phenylpropenal), salicylaldehyde (2-hydroxybenzaldehyde), 4-ethylbenzaldehyde, cuminaldehyde (4-isopropylbenzaldehyde), ethoxybenzaldehyde, 2,4-dimethylbenzaldehyde, veratraldehyde (3,4-dimethoxybenzaldehyde), syringaldehyde (3,5-dimethoxy-4-hydroxybenzaldehyde), catechualdehyde (3,4-dihydroxybenzaldehyde), safranal (2,6,6- Trimethyl-1,3-dienemethanal), myrtenal (pin-2-ene-1-carbaldehyde), perillaldehyde L-4 (1-methylethenyl)-1-cyclohexene-1-carboxaldehyde), 2,4-dimethyl-3-cyclohexene carboxaldehyde, 2-methyl-2-pentenal, 2-methylpentenal, pyruvaldehyde, formyltricyclodecane, mandarin aldehyde, cyclemax, pinoacetaldehyde, corpus iris, maceal, and corpus 4322, but are not limited to these.

The reactive aldehyde may be present in an amount of up to 100% by weight, alternatively 1% to about 100% by weight, alternatively about 2% to about 100% by weight, alternatively about 3% to about 100% by weight, alternatively about 50% to about 100% by weight, alternatively about 70% to about 100% by weight, alternatively about 80% to about 100% by weight, alternatively about 1% to about 20% by weight, alternatively about 1% to about 10% by weight, alternatively about 1% to about 5% by weight, alternatively about 1% to about 3% by weight, alternatively about 2% to about 20% by weight, alternatively about 3% to about 20% by weight, alternatively about 4% to about 20% by weight, alternatively about 5% to about 20% by weight, based on the weight of the fluid composition.

The fluid composition of the present invention may include an effective amount of an acid catalyst to neutralize sulfur-based malodors. Certain mild acids have been found to affect aldehyde reactivity with thiols in the liquid and vapor phases. The reaction between thiols and aldehydes has been found to be a catalyzed reaction that follows the mechanism of hemiacetal and acetal formation pathways. When the fluid composition of the present invention contains an acid catalyst and comes into contact with sulfur-based malodors, the reactive aldehyde reacts with the thiol. This reaction can form thiol acetal compounds, thus neutralizing the sulfur-based odors. In the absence of an acid catalyst, only hemithiol acetals are formed.

Suitable acid catalysts have a vapor pressure (VP) in the range of about 0.001 Torr to about 38 Torr, alternatively about 0.001 Torr to about 14 Torr, alternatively about 0.001 Torr to about 1 Torr, alternatively about 0.001 Torr to about 0.020 Torr, alternatively about 0.005 Torr to about 0.020 Torr, alternatively about 0.010 Torr to about 0.020 Torr, as reported by Scifinder, measured at 25°C.

The acid catalyst may be a weak acid. A weak acid is characterized by an acid dissociation constant, K _a , which is the equilibrium constant for dissociation of the weak acid, with pKa equal to the negative common logarithm of K _a . The acid catalyst may have a pKa of from about 4.0 to about 6.0, alternatively from about 4.3 to about 5.7, alternatively from about 4.5 to about 5, alternatively from about 4.7 to about 4.9. Suitable acid catalysts include those listed in Table 3.

Depending on the desired use of the fluid composition, the odor characteristics or effect on the odor of the fluid composition can be considered when selecting an acid catalyst. It may be desirable to select an acid catalyst that provides a neutral to pleasant odor. Such acid catalysts may have a vapor pressure (VP) measured at 25° C. of about 0.001 Torr to about 0.020 Torr, alternatively about 0.005 Torr to about 0.020 Torr, alternatively about 0.010 Torr to about 0.020 Torr. Non-limiting examples of such acid catalysts include 5-methylthiophene carboxaldehyde with carboxylic acid impurities, succinic acid, or benzoic acid.

The composition may comprise from about 0.05% to about 5% by weight, alternatively from about 0.1% to about 1.0% by weight, alternatively from about 0.1% to about 0.5% by weight, alternatively from about 0.1% to about 0.4% by weight, alternatively from about 0.4% to about 1.5% by weight, alternatively about 0.4% by weight of the acid catalyst based on the weight of the fluid composition.

When an acid catalyst is present with a reactive aldehyde, the acid catalyst can increase the efficacy of the reactive aldehyde against malodors compared to the efficacy of the reactive aldehyde alone against malodors. For example, 1% reactive aldehyde and 1.5% benzoic acid provides equal or better malodor removal efficacy than 5% reactive aldehyde alone.

MICROFLUIDIC CARTRIDGE With reference to Figures 1 and 2, the microfluidic cartridge 10 comprises an interior 12 and an exterior 14. The interior 12 of the microfluidic cartridge 10 comprises a reservoir 16 and one or more fluid channels 18 in fluid communication with the microfluidic die 51. The reservoir 16 may be formed from a base wall 20 or may be formed from multiple surfaces forming the base wall 20 and one or more side walls 22. The reservoir 16 may be enclosed by a lid 24 of the microfluidic cartridge 10. The fluid channel 18 extends from the reservoir 16 to the exterior 14 of the microfluidic cartridge 10 at a fluid opening. The reservoir may include an air vent. The lid 24 may be integral with the reservoir 16 or may be configured as a separate element that is coupled to the reservoir 16.

The reservoir 16 of the microfluidic cartridge 10 may contain from about 5 mL to about 50 mL, alternatively from about 10 mL to about 30 mL, and still alternatively from about 15 mL to about 20 mL of the fluid composition. The reservoir 16 may be fabricated from any material suitable for containing the fluid composition. Suitable materials for the container include, but are not limited to, plastic, metal, ceramic, composites, and the like. The microfluidic cartridge may be configured to have multiple reservoirs, each of which may contain the same or different compositions. The microfluidic delivery device may utilize one or more microfluidic cartridges, each containing a separate reservoir.

The reservoir 16 may also include a porous material 19, such as a sponge, that creates a back pressure to prevent the fluid composition from leaking out of the microfluidic die when the microfluidic die is not in operation. The fluid composition may move through the porous material to the microfluidic die by gravity and/or capillary forces acting on the fluid composition. The porous material may include a metal or fabric mesh, an open-cell polymer foam, a fibrous polyethylene terephthalate, polypropylene, or a two-component fiber or porous wick that contains a plurality of interconnected open cells that form the fluid passageway. The sponge may not include polyurethane foam.

Referring to FIG. 1, the exterior 14 of the microfluidic cartridge 10 consists of two, three, or more sides. Each side is bounded by one or more edges. The two sides are joined along the edges. Each side may be flat, substantially flat, or of various contours. The sides may be joined together to form various shapes, such as a cube, cylinder, cone, tetrahedron, triangular prism, rectangular prism, etc. The microfluidic cartridge may be constructed from a variety of materials, including plastic, metal, glass, ceramic, wood, composites, and combinations thereof. Different elements of the microfluidic cartridge may be constructed from the same or different materials.

The microfluidic cartridge 10 may include at least a first surface 26 and a second surface 28 joined along an edge 30. For example, the first surface 26 may be a bottom surface and the second surface 28 may be a side surface.

In a substantially cubic shaped microfluidic cartridge 10, the microfluidic cartridge 10 may include a top surface, a bottom surface opposite the top surface, and four side surfaces extending between the top surface and the bottom surface. Each of the joined surfaces may be connected along an edge. For example, in a cylindrical shaped microfluidic cartridge, the microfluidic cartridge may include a top surface, a bottom surface opposite the top surface, and a single curved side surface extending between the top surface and the bottom surface.

With reference to FIGS. 1-3, the fluid channel 18 of the microfluidic cartridge 10 may extend to a fluid opening that may be disposed in a second side 28 of the microfluidic cartridge 10. The microfluidic cartridge 10 may include a microfluidic die 51 disposed on the second side 28. The fluid channel 18 may open to the microfluidic die 51 such that the fluid channel 18 is in fluid communication with the microfluidic die 51.

The main components of the microfluidic die are a semiconductor substrate, a flow functional layer, and a nozzle plate layer. The flow functional layer and the nozzle plate layer may be formed from two separate layers or one continuous layer. The semiconductor substrate is preferably made from silicon and includes various passivation, conductive metal, resistive, insulating, and protective layers deposited on its device surface. A fluid ejection actuator in the semiconductor substrate generates a rapid pressure impulse to eject the fluid composition from the nozzle. The rapid pressure impulse may be generated by a heater resistor that volatilizes a portion of the fluid composition in the fluid composition by a rapid heating cycle (e.g., micro-thermonucleation). In the case of a thermal actuator, individual heater resistors are defined in the resistive layer, and each heater resistor corresponds to a nozzle in the nozzle plate to heat and eject the fluid composition from the nozzle.

4 and 5, a simplified diagram of a portion of a microfluidic die 51 is shown. The microfluidic die includes a semiconductor substrate 112, which may be a silicon semiconductor substrate 112 including a number of fluid ejection actuators 114, such as thermal resistors, formed on a device side 116 of the substrate 112, as shown in the simplified diagram of FIG. 5. When the fluid ejection actuators 114 are activated, fluid provided through one or more fluid feed vias 118 in the semiconductor substrate 112 flows through a fluid feed channel 120 to a fluid chamber 122 in a thick film layer 124, where the fluid is ejected through a nozzle 126 in a nozzle plate 128. The fluid ejection actuators are formed on the device side 116 of the semiconductor substrate 112 by well-known semiconductor fabrication techniques. The thick film layer 124 and the nozzle plate 128 may be separate layers or may be one continuous layer.

The nozzle plate 128 may include an oleophobic surface coating. The oleophobic surface coating may include polypropylene, polytetrafluoroethene, and the like.

The nozzle plate 128 may include about 4 to 200 nozzles 126, about 6 to 120 nozzles, or about 8 to 64 nozzles. Each nozzle 126 may deliver about 0.5 picoliters to about 35 picoliters, about 1 picoliters to about 20 picoliters, or about 2 picoliters to about 10 picoliters of the fluid composition per electrical firing pulse. Individual nozzles 126 may typically have a diameter of about 0.0024 inches (5 micrometers to 50 micrometers). The flow rate of the fluid composition emitted from the microfluidic die 51 may be in the range of about 5 mg to about 70 mg/hour, or any other suitable flow rate or range of flow rates.

1 and 3, the microfluidic cartridge 10 includes an electrical circuit 52. The electrical circuit 52 may be in the form of a flexible circuit board, a semi-flexible circuit board having rigid and flexible portions, or a rigid circuit board. The electrical circuit 52 may include a first end 54, a second end 56, and a central portion 58 separating the first end 54 and the second end 56. The first end 54 of the electrical circuit 52 may include electrical contacts 60 for connecting with electrical contacts of a housing of the microfluidic delivery device. The second end 56 of the electrical circuit 52 may be in electrical communication with the microfluidic die 51.

When the electrical circuitry 52 is flexible or semi-flexible, the electrical circuitry 52 may be disposed on and span two faces of the microfluidic cartridge 10. For purposes of illustration only, and with reference to, for example, FIGS. 1 and 3, a first end 54 of the electrical circuitry 52 may be disposed on the first face 26 of the microfluidic cartridge 10, a second end 56 of the electrical circuitry 52 may be disposed on the second face 28 of the microfluidic cartridge 10, and a central portion 58 of the electrical circuitry 52 may span the first face 26 and the second face 28 of the microfluidic cartridge 10.

If the electrical circuitry 52 is a rigid circuit, the electrical circuitry 52 may be disposed on a single surface of the microfluidic cartridge 52 such that the microfluidic die 51 and the electrical contacts 60 are disposed on the same surface.

1 and 6-8, the microfluidic cartridge 10 may also include one or more cartridge connectors 36 for providing a mechanical connection between the microfluidic cartridge 10 and the housing. The cartridge connector 36 on the microfluidic cartridge 10 may couple or mate with a corresponding housing connector on the housing. For example, the cartridge connector 36 may be configured as a female connector, such as an opening configured to mate with one or more male connectors, such as protrusions or guide posts, on the housing. Alternatively, the cartridge connector 36 may be configured as a male connector that may include one or more protrusions, such as guide posts, configured to mate with one or more female connectors, such as openings on the housing. The mechanical connection between the microfluidic cartridge and the housing may help to properly align and secure the microfluidic cartridge within the housing to provide a secure electrical connection between the microfluidic cartridge and the housing.

With reference to FIGS. 6-8, the microfluidic cartridge 10 may be configured to be releasably coupled to a housing 46 of the microfluidic delivery device 44. The housing 46 may be connected to a power source 48. The housing 46 may include a receptacle 64 having an opening 66 for receiving the microfluidic cartridge 10. The receptacle 64 may receive a portion of the microfluidic cartridge 10, or the microfluidic cartridge 10 may be completely disposed in its entirety within the receptacle 64. The receptacle 64 of the housing 46 may include electrical contacts 68 configured to electrically connect with the electrical contacts 60 of the microfluidic cartridge 10.

The receptacle 64 may include one or more housing connectors 38 configured to be received by one or more cartridge connectors 36 of the microfluidic cartridge 10. The housing connectors 38 may be in the form of a male or female connector. For example, if the cartridge connector 36 is configured as a female connector, the housing connector 38 may be configured as a male connector, or vice versa. The housing connectors 38 and the cartridge connectors 36 may be sized and shaped to mate with one another to provide a sufficient mechanical and electrical connection.

The housing 46 may include a faceplate 47 disposed on a front side of the housing 46. The housing 46 may also include a fluid outlet 74 for releasing the fluid composition from the microfluidic cartridge 10 into the air. The housing 46 may include an air outlet 76 for directing air toward the dispensed fluid composition to direct the fluid composition upward and/or outward and into the surrounding space. The fluid outlet 74 and the air outlet 76 may be disposed within the faceplate 47.

1 and 8, the cartridge connector 36 and the housing connector 38 may be used to align, secure, and limit movement of the microfluidic cartridge 10 relative to the housing of the microfluidic delivery device 44 to establish a strong electrical connection between the microfluidic cartridge 10 and the housing. The cartridge connector 36 and the housing connector 38 may be designed to provide either macro or micro alignment of the microfluidic cartridge 10. The cartridge connector 36 may be mated with the housing connector 38 to prevent movement of the microfluidic cartridge 10 in the X and Y directions relative to the housing 46 of the microfluidic delivery device 44.

8, the microfluidic cartridge 10 may be spring loaded against the housing 46 to provide a secure electrical connection between the microfluidic cartridge 10 and the housing 46. The microfluidic cartridge 10 may have a release button for removing the microfluidic cartridge 10 from the housing 46. Alternatively, the microfluidic cartridge 10 may be pushed towards the housing 46 to engage and/or disengage the microfluidic cartridge 10 from the housing 46. The microfluidic cartridge 10 may engage with a fastener 102 or clip to connect the microfluidic cartridge 10 to the housing 46.

The receptacle 64 may include one or more guide rails for orienting the microfluidic cartridge 10 within the receptacle 64.

The microfluidic delivery device may be configured to be compact and easily portable. In such cases, the microfluidic delivery device may be battery operated. The microfluidic delivery device may be capable of being used with power sources such as a 9 volt battery, conventional dry cell batteries such as "Type A", "AA", "AAA", "C" and "D" batteries, button cells, watch batteries, solar cells, and rechargeable batteries with recharging bases.

The microfluidic delivery device may include a fan that generates an air flow to assist in delivering the fluid composition into the air. Any fan that provides the desired air flow rate, size, and power requirements of the microfluidic delivery device may be used. The fan may be used to push the fluid composition further into the air and/or to direct the fluid composition in a direction different than the direction in which the fluid composition is dispensed from the microfluidic die. The fan may be disposed inside the housing, or at least partially inside the housing, or outside the housing. The fan may also be used to direct air over the microfluidic die 51 to minimize the amount of fluid composition that is deposited back onto the microfluidic die 51.

The microfluidic die 92 may be controlled and driven by an external microcontroller or microprocessor, which may be provided within the housing.

A method of spraying a cooling composition may include heating the fluid composition with a thermal actuator and spraying the heated composition from a nozzle at an angle between 0 degrees and 90 degrees relative to the force of gravity. Heating the fluid composition may be accomplished using a thermally actuated microfluidic die.

The microfluidic delivery device and method of delivery of a freshening composition may be used to deliver a fluid composition into the air. The microfluidic delivery device may also be used to deliver a fluid composition into the air for ultimate deposition on one or more surfaces within a space. Exemplary surfaces include hard surfaces such as counters, appliances, flooring, and the like. Exemplary surfaces also include carpets, furniture, clothing, bedding, linens, curtains, and the like. The microfluidic delivery device may be used in homes, offices, businesses, open spaces, automobiles, temporary spaces, and the like. The microfluidic delivery device may be used for freshening, odor removal, insect control, and the like.

To evaluate the performance of the solubilizers against nozzle clogging or gel loss, a fluid composition containing 25% by weight of each solubilizer in Table 4 below was combined with 75% of the fragrance mixture described in Table 5 below. The fluid composition was mixed for about 1 hour and then inserted into a microfluidic cartridge using a vacuum filler. The filled microfluidic cartridge was placed in an electronic fixture that could fire the contents of the microfluidic cartridge at regular intervals for about 14 days or until the fluid composition was exhausted. The operating conditions for each sample were the same and are summarized as follows: the microfluidic die substrate was preheated to 30°C immediately before ejecting the droplets. Each of the 32 thermal actuators was operated at a firing frequency of 1000 Hz. The firing energy was about 8% greater than the minimum energy required to fire a droplet, with each thermal actuator firing 550 times per 10 seconds. The minimum firing energy required was determined by the fixture using an algorithm that estimates the onset of jetting from the thermal response of the microfluidic die. Visual images of the die were captured daily using a Keyence digital microscope at 500x magnification (lens: VH-Z100R/W/T). The weight of each filled microfluidic cartridge was also recorded before and after filling, and daily evaluations were performed to track the average hourly dispense rate and nozzle blockage.

The results for nozzle buildup/solidified liquid and nozzle blockage for each composition after 14 days are shown in Table 6 below using the visual scale in Figure 9.

All samples were run under the same conditions with comparable parameters to ensure an accurate comparison of the effectiveness of the solubilizers.

The dimensions and values disclosed herein should not be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise indicated, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a dimension disclosed as "40 mm" is intended to mean "about 40 mm."

It should be understood that every maximum numerical limitation given throughout this specification includes every lower numerical limitation, as if such lower numerical limitations were expressly written herein. Every minimum numerical limitation given throughout this specification includes every higher numerical limitation, as if such higher numerical limitations were expressly written herein. Every numerical range given throughout this specification includes every narrower numerical range that is included within such broader numerical range, as if such narrower numerical ranges were all expressly written herein.

All documents cited herein, including any cross-referenced or related patents or patent applications, and any patent applications or patents to which this application claims priority or the benefit thereof, are incorporated herein by reference in their entirety, unless expressly stated to the contrary. The citation of any document shall not be deemed to be prior art to any invention disclosed or claimed herein, or to teach, suggest or disclose such invention, either alone or in combination with any other reference(s). Furthermore, to the extent that any meaning or definition of a term in this document conflicts with any meaning or definition of the same term in a document incorporated by reference, the meaning or definition given to that term in this document shall govern.

While particular embodiments of the present invention have been illustrated and described, it would be apparent to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (6)

1. A microfluidic cartridge releasably connectable to a housing, comprising:
the cartridge comprising a reservoir for containing a fluid composition and a microfluidic die in fluid communication with the reservoir;
the composition comprises greater than 20% by weight of a solubilizing material that is liquid at 20° C.;
the solubilizing material is selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof;
The composition comprises more than 50% by weight of a fragrance mixture based on the weight of the total composition,
The microfluidic cartridge , wherein the fragrance mixture has a molar weighted average boiling point between 150°C and 250°C . The cartridge of claim 1, wherein the composition comprises greater than 20% to 25% by weight of the solubilizing material based on the weight of the entire composition. The cartridge of claim 1 or 2, wherein the composition has a CLogP of less than 3.5. 1. A method of spraying a composition, comprising:
providing a composition comprising greater than 20% by weight of a solubilizing material that is liquid at 20° C.;
heating the composition with a thermal actuator;
spraying the heated composition from a nozzle in a direction of 0 to 90 degrees with respect to the direction of gravity;
Including,
the solubilizing material is selected from the group consisting of phenylmethanol, 2-(2-hydroxypropoxy)propan-1-ol, propane-1,2-diol, 1-((1-propoxypropan-2-yl)oxy)propan-2-ol, 1-(2-methoxypropoxy)propan-2-ol, 4-allyl-2-methoxyphenol, 2-phenylethan-1-ol, and combinations thereof;
The composition comprises more than 50% by weight of a fragrance mixture based on the weight of the total composition,
The method of claim 1, wherein said fragrance mixture has a molar weighted average boiling point of from 150°C to 250°C . 5. The method of claim 4, wherein the step of spraying the heated composition further comprises spraying the heated composition from a nozzle of a microfluidic delivery member, the microfluidic delivery member comprising a silicon semiconductor substrate including a plurality of heater resistors, at least one fluid chamber associated with each heater resistor, and at least one nozzle associated with each fluid chamber. The method of claim 4 or 5 , wherein the composition comprises from greater than 20% to 25% by weight of the solubilizing material based on the weight of the total composition.