JP7178996B2 - antibacterial composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an antibacterial composition that can be used in cosmetics and the like.

Antibacterial agents (preservatives) are often used in cosmetics and the like for the purpose of preserving them. Parabens are most commonly used as antibacterial agents in cosmetics, but parabens are highly irritating to the skin, and their concentration in cosmetics is limited to 1% by mass or less. Recently, the number of people who have allergic reactions to parabens is increasing, and the demand for cosmetics that do not contain parabens is increasing. It is known that the combined use of parabens and benzyloxyethanol provides high antibacterial properties (see, for example, Patent Documents 1 and 2). The reaction cannot be eliminated.

On the other hand, alkanediol compounds such as 1,2-octanediol have high antibacterial properties and are more safe to the human body than parabens, so they are used in cosmetics as antibacterial agents to replace parabens. (See Patent Documents 3 and 4, for example). However, the alkanediol compound may lower the antibacterial properties in emulsified cosmetics. Moreover, although it has high antibacterial properties against bacteria, its antibacterial properties are insufficient against fungi such as molds.
Therefore, there is a demand for the development of an antibacterial agent that exhibits high antibacterial properties even in an emulsified system, is effective against not only bacteria but also fungi, and can be incorporated in cosmetics and the like.

JP-A-2005-232055 JP-A-2005-232056 JP-A-11-322591 Japanese Patent Application Laid-Open No. 2001-048720

Accordingly, the present inventors conducted extensive studies and found that an alkanediol compound has a synergistic antibacterial effect with benzyloxyethanol, leading to the present invention. That is, the present invention is an antibacterial composition containing a diol compound represented by the following general formula (1) as component (A) and benzyloxyethanol as component (B).

(In the formula, ^R1 represents a butyl group, a hexyl group or an octyl group .)

The effect of the present invention is to provide an antibacterial composition that exhibits high antibacterial properties even in an emulsified system and has high antibacterial properties against fungi such as mold.

The diol compound represented by the general formula (1), which is the component (A) of the present invention, will be described. In general formula (1), R ¹ represents an alkyl group having 3 to 8 carbon atoms. Examples of alkyl groups having 3 to 8 carbon atoms include propyl, isopropyl, butyl, isobutyl, secondary butyl, t-butyl, pentyl, isopentyl, secondary pentyl, t-pentyl and hexyl. group, secondary hexyl group, heptyl group, secondary heptyl group, octyl group, secondary octyl group, 2-methylpentyl group, 2-ethylhexyl group and the like. R ¹ is preferably a propyl group, a butyl group, a pentyl group, a hexyl group, or a heptyl group, more preferably a pentyl group or a hexyl group, and most preferably a hexyl group, because of their high antibacterial properties. Preferred specific examples of the diol compound represented by formula (1) include 1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-octanediol, 2-nonanediol and the like.

The (B) component of the present invention is benzyloxyethanol.
In general, the ratio of component (A) to component (B) is not particularly limited. :80 to 80:20, most preferably 30:70 to 70:30. If the mass ratio of component (A) to component (B) is extremely large, the effect of component (B) on improving the antibacterial properties of component (A) may be small, and the mass ratio is extremely small. In some cases, the antibacterial properties of component (A) may decrease.

The amount of the antibacterial composition of the present invention used varies depending on the application, and is not particularly limited. Therefore, the total amount of components (A) and (B) is preferably 0.001 to 10% by mass, more preferably 0.01 to 3% by mass, based on the total amount of the product. , 0.1 to 2% by weight is most preferred.

Since the antibacterial composition of the present invention enhances the antibacterial effect, it further contains, as the component (C), a chelating agent, a low-molecular-weight polyol (excluding diol compounds corresponding to the component (A)), and a nitrogen-containing nonionic surfactant. It preferably contains one or more compounds selected from the group consisting of an ampholytic agent, nitrogen-containing amphoteric surfactant, plant-derived extract, and zinc compound.

Chelating agents include, for example, aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, ether polycarboxylic acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, Hydroxycarboxylic acid chelating agents, polyelectrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, glyoxalic acid and the like. These chelating agents may be in free acid form or in the form of salts such as sodium salts, potassium salts and ammonium salts. Furthermore, they may be in the form of their hydrolyzable ester derivatives.

Examples of aminopolycarboxylic acid-based chelating agents include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, diethylenetriaminepentaacetic acid, N-(2 -hydroxyethyl)ethylenediaminetriacetic acid, glycol ether diaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid and salts thereof.

Examples of aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and their salts, methyl esters and ethyl esters.

Amino acid-based chelating agents include, for example, glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts and derivatives thereof.
Examples of hydroxycarboxylic acid-based chelating agents include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.

Phosphonic acid-based chelating agents include, for example, iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof.
Phosphate-based chelating agents include, for example, orthophosphoric acid, pyrophosphoric acid, triphosphoric acid and polyphosphoric acid.

Polyelectrolyte (including oligomer electrolyte) chelating agents include, for example, acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and two monomers constituting these polymers. Copolymers and epoxy succinic acid polymers comprising the above are mentioned.

Among these chelating agents, ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, glutamic diacetic acid, aspartic diacetic acid, succinic acid, salicylic acid, oxalic acid, lactic acid , fumaric acid, citric acid, tartaric acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred, ethylenediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, glutamic acid di Acetic acid, aspartic diacetic acid, succinic acid, lactic acid, tartaric acid and salts thereof are more preferred, and ethylenediaminetetraacetic acid, glutamic diacetic acid, aspartic diacetic acid and salts thereof are most preferred.

The amount of the chelating agent to be added is not particularly limited. However, if the amount of the chelating agent is too small, the effect of improving the antibacterial properties may not be obtained, and if the amount of the chelating agent is too large, the antibacterial properties corresponding to the amount added cannot be obtained. It is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, even more preferably 2 to 100 parts by mass, and particularly preferably 10 to 75 parts by mass, based on 100 parts by mass of the component.

Examples of low-molecular-weight polyols (excluding diol compounds corresponding to component (A)) include ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,3 -propanediol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, 2-methyl-1,2-propanediol, 2-methyl-1,3 - propanediol, 1,3-pentanediol, 1,4-pentanediol, 1,5-pentanediol, 2,3-pentanediol, 2,4-pentanediol, 2-methyl-1,2-butanediol, 2-methyl-2,3-butanediol, 2-methyl-1,4-butanediol, 3-methyl-1,3-butanediol, 2-ethyl-1,3-propanediol, 2,2-dimethyl-1 ,3-propanediol, 1,5-hexanediol, 1,6-hexanediol, 2,5-hexanediol, 3,3-hexanediol, 2-methyl-1,3-pentanediol, 2-methyl-1 ,5-pentanediol, 2-methyl-2,4-pentanediol, 3-methyl-1,5-pentanediol, 3-methyl-2,3-pentanediol, 3-methyl-2,4-pentanediol, 2-ethyl-2-methyl-1,3-propanediol, 2,2-dimethyl-2,4-butanediol, 1,7-heptanediol, 3,4-heptanediol, 2-propyl-2-methyl- 1,3-propanediol, 2-isopropyl-2-methyl-1,3-propanediol, 1,8-octanediol, 3,6-octanediol, 2-ethyl-1,3-hexanediol, 2-sec -butyl-2-butyl-1,3-propanediol, 2,2-dimethyl-1,3-hexanediol, 2,5-dimethyl-2,5-hexanediol, 2,2,4-trimethyl-1, 3-pentanediol, 1,3-nonanediol, 1,9-nonanediol, 3,6-octanediol, 2-ethyl-2-(2-methyl)propyl-1,3-propanediol, 2,2, 4-trimethyl-1,6-hexanediol, 2,4,4-trimethyl-1,6-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 2,4-diethyl-1,5 - Pentanedio 2-methyl-1,8-octanediol, 1,10-decanediol, 5,6-decanediol, 3,6-dimethyl-3,6-octanediol, 3,7-dimethyl-1,6- Octanediol, 3,7-dimethyl-1,7-octanediol, 1,2-undecanediol, 1,4-undecanediol, 1,11-undecanediol, 6-ethyl-3-methyl-1,6-octane Diol, 1,2-dodecanediol, 1,10-dodecanediol, 1,12-dodecanediol, 2,4-diethyl-1,5-octanediol, 2,8,8-trimethyl-2,7-nonanediol , 1,2-tetradecanediol, 1,14-tetradecanediol, 7,8-tetradecanediol, 1,2-pentadecanediol, 1,2-hexadecanediol, 1,16-hexadecanediol, 1,17-heptadecanediol , 1,2-octadecanediol, 1,12-octadecanediol, 1,2-eicosanediol, 1,2-docosanediol, 1,2-tetracosanediol, saturated diols or condensates thereof;

2-butene-1,4-diol, 3-butene-1,2-diol, 2-methylene-1,3-propanediol, 2-butyne-1,4-diol, 5-hexene-1,2-diol , 3-methyl-2-pentene-1,5-diol, 3-methylenepentane-1,5-diol, 1,5-hexadiene-3,4-diol, 7-octene-1,2-diol, 2, 5-dimethyl-3-hexene-2,5-diol, 9-decene-1,2-diol, 2,6-dimethyl-7-octene-2,6-diol, 3,7-dimethyl-7-octene- 1,6-diol, 13-tetradecene-1,2-diol, 12-hydroxy-9-octadecenol, 2-pentyne-1,4-diol, 3-hexyne-2,5-diol, 4-methyl-2- Pentyne-1,4-diol, 3-heptyne-2,5-diol, 4-methyl-2-pentyne-1,4-diol, 3,4-dimethyl-1-pentyne-3,4-diol, 2, 5-dimethyl-3-hexyne-2,5-diol, 5-decyne-4,7-diol, 2,6-dimethyl-7-octyne-2,6-diol, 3,6-dimethyl-4-octyne- 3,6-diol, 2,3,6,7-tetramethyl-4-octyne-3,6-diol, 2,4,7,9-tetramethyl-5-decyne-4,7-diol, 2, 5,8,11-tetramethyl-6-dodecyne-5,8-diol, 1,1,4,4-tetraisopropyl-4-octyne-3,6-diol, 5,10-diethyl-7-tetradecyne- unsaturated diols such as 6,9-diol;

1,2-cyclopentanediol, 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Diol, 2,5-norbornanediol, 2,7-norbornanediol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol , 1,5-decalinediol, limonene glycol, 1,2-terpenediol, 4,4′-bicyclohexanediol, 1,2-cyclododecanediol and other alicyclic diols;

Glycerin, 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol , 1,3,5-pentanetriol, 2,3,4-pentanetriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-butanetriol, trimethylolpropane, 4-propyl-3,4,5-heptanetriol, 2,4-dimethyl-2,3,4-pentanetriol, triethanolamine, triisopropanolamine, etc. alcohol;

Erythritol, pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentanetetrol, 1,3,4,5-hexane Tetrol, diglycerin, sorbitan, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, N,N,N',N'-tetrahydric alcohols such as tetrakis(hydroxyethyl)ethylenediamine;

pentahydric alcohols such as adonitol, arabitol, xylitol, triglycerin;
Hexavalent alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, dulcitol, talose and allose;

1-methyl glyceryl ether, 2-methyl glyceryl ether, 1-ethyl glyceryl ether, 2-ethyl glyceryl ether, 1-propyl glyceryl ether, 2-propyl glyceryl ether, 1-isopropyl glyceryl ether, 2-isopropyl glyceryl ether, 1- Butyl glyceryl ether, 2-butyl glyceryl ether, 1-isobutyl glyceryl ether, 2-isobutyl glyceryl ether, 1-pentyl glyceryl ether, 2-pentyl glyceryl ether, 1-hexyl glyceryl ether, 2-hexyl glyceryl ether, 1-heptyl glyceryl ether, 2-heptyl glyceryl ether, 1-octyl glyceryl ether, 2-octyl glyceryl ether, 1-(2-ethylhexyl) glyceryl ether, 2-(2-ethylhexyl) glyceryl ether, 1-nonyl glyceryl ether, 2-nonyl glyceryl ether, 1-decyl glyceryl ether, 2-decyl glyceryl ether, 1-undecyl glyceryl ether, 2-undecyl glyceryl ether, 1-dodecyl glyceryl ether, 2-dodecyl glyceryl ether, 1-tridecyl glyceryl ether, 2-tri Decyl glyceryl ether, 1-tetradecyl glyceryl ether, 2-tetradecyl glyceryl ether, 1-hexadecyl glyceryl ether, 2-hexadecyl glyceryl ether, 1-octadecyl glyceryl ether, 2-octadecyl glyceryl ether, 1-branched octadecyl glyceryl Ether, 2-Branched Octadecyl Glyceryl Ether, 1-Eicosyl Glyceryl Ether, 2-Eicosyl Glyceryl Ether, 1-Allyl Glyceryl Ether, 2-Allyl Glyceryl Ether, 1-Undecenyl Glyceryl Ether, 2-Undecenyl Glyceryl Ether glycerin monoethers such as ether, 1-oleyl glyceryl ether, 2-oleyl glyceryl ether, 2-cyclohexyl glyceryl ether, 2-phenyl glyceryl ether;

N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N-(2-ethylhexyl)diethanolamine;

N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N-(2-ethylhexyl)di N-substituted diisopropanolamines such as isopropanolamine;

3-dimethylamino-1,2-propanediol, 3-diethylamino-1,2-propanediol, 3-dipropylamino-1,2-propanediol, 3-diisopropylamino-1,2-propanediol, 3- Examples include N,N-disubstituted-3-amino-1,2-propanediols such as dibutylamino-1,2-propanediol.

Among these low-molecular-weight polyols, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1,2-butanediol, 1,3-butanediol, 2,3-butanediol, 3 -methyl-1,3-butanediol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 1,10-decanediol, glycerin, triethanolamine, triisopropanol Amine, erythritol, diglycerin, sorbitan, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, N,N,N',N'-tetrakis(hydroxyethyl)ethylenediamine, sorbitol, 1-methyl Glyceryl ether, 1-ethyl glyceryl ether, 1-propyl glyceryl ether, 1-butyl glyceryl ether, 1-allyl glyceryl ether are preferred, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, 1 , 3-butanediol, 3-methyl-1,3-butanediol, glycerin, triethanolamine, diglycerin, sorbitan, N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, sorbitol, 1- Allyl glyceryl ether is more preferred, and propylene glycol, dipropylene glycol, 1,3-butanediol, 3-methyl-1,3 butanediol, glycerin, sorbitol and 1-allyl glyceryl ether are even more preferred.

The amount of the low-molecular-weight polyol is not particularly limited, but if the amount of the low-molecular-weight polyol is too small, the effect of improving the antibacterial properties may not be obtained, and if it is too large, the antibacterial properties cannot be improved to match the amount added. , The amount of the low-molecular-weight polyol is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, even more preferably 2 to 100 parts by mass, based on 100 parts by mass of component (A). 75 parts by weight is particularly preferred.

Nitrogen-containing nonionic surfactants include, for example, compounds represented by the following general formulas (2) to (8).

(In the formula, R ² represents an alkyl group or alkenyl group, R ³ represents an alkyl group, an alkenyl group or a group represented by --(CH ₂ CH ₂ O) _b --H, and a and b are each 1 to 20. represents the number of

(In the formula, R ⁴ represents an alkyl group or an alkenyl group, c, d and e each represent a number from 1 to 20, and f represents a number from 2 to 3.)

( ^In the formula, R5 represents an alkyl group or an alkenyl group.)

(In the formula, R ⁶ represents an alkyl group or alkenyl group, R ⁷ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by -(R ⁹ O) _h -H, and R ⁸ and R ⁹ each represents an alkylene group having 2 to 3 carbon atoms, and g and h each independently represents a number of 1 to 20.)

(In the formula, R ¹⁰ and R ¹¹ represent an ethylene group or a propylene group, and j and k each independently represents a number of 1 to 200. However, R ¹⁰ and R ¹¹ are not the same group. )

(In the formula, R ¹² represents an alkyl group or an alkenyl group.)

(In the formula, R ¹³ represents an alkyl group or an alkenyl group, and m represents the number of 2 or 3.)

In general formula (2), R ² represents an alkyl group or alkenyl group, R ³ represents an alkyl group, an alkenyl group or a group represented by -(CH ₂ CH ₂ O) _b -H, and a and b are each Represents a number from 1 to 20. R ² is preferably an alkyl or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl or alkenyl group having 12 to 18 carbon atoms. Also, R ³ is preferably a group represented by --(CH ₂ CH ₂ O) _b --H. The total value of a and b is preferably from 2 to 10, more preferably from 2 to 4.

In general formula (3), R ⁴ represents an alkyl group or an alkenyl group, c, d and e each represent a number of 1-20, and f represents a number of 2-3. R ⁴ is preferably an alkyl or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl or alkenyl group having 12 to 18 carbon atoms. As for c, d and e, the total value of c, d and e is preferably a number of 3-10, more preferably a number of 3-5. Also, f is preferably a number of 2 to 3, more preferably a number of 3.

In general formula ( ⁴ ), R5 represents an alkyl group or an alkenyl group. R ⁵ is preferably an alkyl or alkenyl group having 8 to 22 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 18 carbon atoms, and even more preferably an alkyl or alkenyl group having 10 to 14 carbon atoms.

In general formula (5), R ⁶ represents an alkyl group or an alkenyl group, R ⁷ represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group represented by —(R ⁹ O) _h —H, and R ⁸ and R ⁹ each represent an alkylene group having 2 to 3 carbon atoms, and g and h each independently represent a number of 1 to 20; R ⁶ is preferably an alkyl or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 17 carbon atoms, and even more preferably an alkyl group having 11 to 13 carbon atoms. R ⁷ is preferably a hydrogen atom, a methyl group or --CH ₂ CH ₂ OH, more preferably a hydrogen atom or a methyl group. When R ⁷ is a hydrogen atom, g preferably has a number of 1 to 3, more preferably R ⁸ is an ethylene group and g is 1. When R ⁷ is a methyl group, R ⁸ is preferably an ethylene group, more preferably R ⁸ is an ethylene group and g is 1. When R ⁷ is --CH ₂ CH ₂ OH, it is preferred that R ⁸ is ethylene and g is 1. Moreover, it is preferable that h is 1.

In general formula (6), R ¹⁰ and R ¹¹ each represent an ethylene group or a propylene group, and j and k each independently represents a number from 1 to 200, not 0. It is preferred that R ¹⁰ is a propylene group and R ¹¹ is an ethylene group. Also, j is preferably a number from 7 to 25, more preferably a number from 10 to 15, and even more preferably a number from 11 to 13. Furthermore, the value of j is preferably 10 to 200%, more preferably 20 to 150%, even more preferably 50 to 100% of the value of k.

In general formula (7), R ¹² represents an alkyl group or an alkenyl group. R ¹² is preferably an alkyl group or alkenyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and even more preferably an alkyl group having 10 to 14 carbon atoms.

In general formula (8), R ¹³ represents an alkyl group or an alkenyl group, and m represents the number of 2 or 3. R ¹³ is preferably an alkyl or alkenyl group having 8 to 17 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. Moreover, the number of 3 is preferable for m.

Among these nitrogen-containing nonionic surfactants, compounds represented by general formulas (2), (4), (5) and (7) are preferred, and general formulas (2), (5) and (7) is more preferred, and general formula (5) is most preferred.

The amount of the nitrogen-containing nonionic surfactant is not particularly limited, but if the amount of the nitrogen-containing nonionic surfactant is too small, the effect of improving antibacterial properties may not be obtained, and if it is too large, the effect of increasing the amount corresponding to the amount is obtained. Therefore, the amount of the nitrogen-containing nonionic surfactant is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, more preferably 2 to 100 parts by mass based on 100 parts by mass of component (A). Even more preferably, 10 to 75 parts by mass is particularly preferable.

Nitrogen-containing amphoteric surfactants include, for example, compounds represented by the following general formulas (9) to (14):

(R ¹⁴ represents an alkyl group and n represents a number from 1 to 3.)

(R ¹⁵ represents an alkyl group or an alkenyl group, and p represents a number of 2-3.)

(R ¹⁶ represents an alkyl group or an alkenyl group, and q represents a number of 2-3.)

(R ¹⁷ represents an alkyl group or an alkenyl group.)

(R ¹⁸ represents an alkyl group or an alkenyl group, and r represents a number of 2-3.)

(R ¹⁹ represents an alkyl group or an alkenyl group, and s represents a number of 2-3.)

In general formula (9), R ¹⁴ represents an alkyl group and n represents a number of 1-3. R ¹⁴ is preferably an alkyl group having 9 to 18 carbon atoms, more preferably an alkyl group having 10 to 16 carbon atoms, and even more preferably an alkyl group having 10 to 14 carbon atoms. Also, the value of n is preferably 1.

In formula (10), R ¹⁵ represents an alkyl group or alkenyl group, and p represents a number of 2-3. R ¹⁵ is preferably an alkyl or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 15 carbon atoms, and even more preferably an alkyl group having 9 to 13 carbon atoms. Moreover, the number of 3 is preferable for p.

In general formula (11), R ¹⁶ represents an alkyl group or alkenyl group, and q represents a number of 2-3. R ¹⁶ is preferably an alkyl or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Moreover, the number of 3 is preferable for q.

In general formula (12), R ¹⁷ represents an alkyl or alkenyl group, preferably an alkyl or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 15 carbon atoms, and 9 carbon atoms. Alkyl groups of -13 are more preferred.

In general formula (13), R ¹⁸ represents an alkyl group or alkenyl group, and r represents a number of 2-3. R ¹⁸ is preferably an alkyl or alkenyl group having 8 to 18 carbon atoms, more preferably an alkyl or alkenyl group having 10 to 16 carbon atoms, and still more preferably an alkyl group having 10 to 14 carbon atoms. Moreover, the number of 3 is preferable for r.

In general formula (14), R ¹⁹ represents an alkyl group or alkenyl group, and s represents a number of 2-3. R ¹⁹ is preferably an alkyl or alkenyl group having 7 to 21 carbon atoms, more preferably an alkyl or alkenyl group having 9 to 15 carbon atoms, and still more preferably an alkyl group having 9 to 13 carbon atoms. Moreover, the number of 3 is preferable for s.

Among these nitrogen-containing amphoteric surfactants, compounds represented by general formulas (9), (10) and (11) are preferable, and general formulas (10) and (11) are more preferable. ) is most preferred.

The amount of the nitrogen-containing amphoteric surfactant is not particularly limited, but if the amount of the nitrogen-containing amphoteric surfactant is too small, the effect of improving the antibacterial properties may not be obtained, and if it is too large, the effect of increasing the amount of the nitrogen-containing amphoteric surfactant can be obtained. Therefore, the amount of the nitrogen-containing amphoteric surfactant is preferably 0.5 to 500 parts by mass, more preferably 1 to 200 parts by mass, and more preferably 2 to 100 parts by mass based on 100 parts by mass of component (A). Even more preferably, 10 to 75 parts by mass is particularly preferable.

In the present invention, the plant-derived extract refers to all of plants, algae or fungi, or specific parts such as flowers, leaves, stems, fruits, bark, roots, seeds, resins, etc. etc., and then extracted with a solvent at room temperature or under heating, and is soluble in water, ethanol, propylene glycol, or fats and oils. Alternatively, the extract may be diluted, concentrated, or dried. Further, essential oils may be obtained by steam distillation, extraction, chromatography, or the like.

Examples of extraction solvents include those commonly used for extracting natural product components, such as water; alcohols such as methanol, ethanol, propanol and butanol; polyhydric alcohols such as ethylene glycol, propylene glycol, butylene glycol and glycerin; acetone and methyl ethyl ketone. Esters such as methyl acetate and ethyl acetate; Ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; Halogenated hydrocarbons such as dichloroethane and chloroform; hydrocarbons; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solutions, etc.;

Plants that can be used as plant-derived extracts include, for example, artichoke, almond, eye, Eisenhardtia polystachia, eyebright, blue agave, aomoji, acacia concinna, acacia senegal, acacia senegal gum, acacia declens, red clover, Red elm, red yam, Aggi, Agrimonia eupatoria, akebi, morning glory karakusa, thistle, reed, Ashitaba, Ajuga tulkestanica, adzuki bean, Asunaro, Asparagus, Aspalathus linearis, Acerola, Asenyak, Asparagus catechu, Atlas cedar, Anise, Ano Geissleiocarpus, Avenastrigosa, Avocado, Flax, Gynostemma, Jiaogulan, Polygonum, Eelgrass, Amyris balsamifera, Honey locust, American salamander, American pepper, American carrot, Amomum aromaticum, glauca, arcana, arctium majus , Arctium Minus, Arnica, Arnica Camisonis, Alpinia officinalum, Alfalfa (a.k.a. Alfalfa), Aloe Vera, Anzange, Apricot, Angelica, Antris Brunelaria, Ampelopsis Gloucedentata, Ammarok, Epimedium, Ipomoea, Japanese knotweed, Italian cypress, strawberry, fig, Japanese mustard, ginkgo biloba, itran, carob, Ibukitoranoo, imosemil, nettle, ylang-ylang, iris, irispalida, Rhodiola rosea, Rhodiola japonicum, kidney bean, fennel, withania somnifera, turmeric, turmeric, Nepenthes, Udo, Sea buckthorn, Plum, Uyaku, Ural licorice, Cucurbit, Urbara tsuka, Ulmus davidiana, Uncaria tomentosa, Unshu mandarin, Agitsu, Eilanthai, Edelweiss, Eleuthero, Ezo snake strawberry, Ezo loosestrife, Echinashi, Echinacea parida, Broom, Ebine, Ebrico, Elm, Elemi, Japanese pagoda, Pea, Enpithus japonica, Trichophyllum, Mugwort, Coptis, Milk thistle, Giant melon, Ozodenda, Great crow's pea, Orchis makurata, Orchis muskrat, Orchid,

Oak (a.k.a. European oak), Phyllanthus oleifera, Ovana okera, Obanana cacao, Lagerstroemia myrtle, Mikan mandarin orange, Omi long-nosed palm, Passionflower, Barley, Allspice, Okazeri, Okra, Mirage, Panax ginseng, Hypericum, Thosiger's walnut, Salvia, Onihama radish, Ononis , Opuntia streptacantha, Opuntia tuna, Dutch mustard, Dutch peony, Olive, Origanum heracleoticum, Ortosiphon stamineus, Olmenis multicaulis, Orange, Orobancerapum, Gardenia tahitensis, Carnation, Carya senegalensis , cacao, cakyoku, cassia, cashew nut, cascara sagrada, cassia italica, kappa ficus alvarez, cattleya, canadian hydrastis, canary tree, canina rose, valerian, birch mushroom, turnip, cattail, chamomile (aka chamomile), Kamimebuki, cajeput, larch salmon, oats, larch, guarana, Garikabara, cauliflower, Chinese quince, calluna (a.k.a. calluna), garcinia cambogia, carrots, kawara mugwort (a.k.a. wormwood), licorice, agarwood, raspberry, kiwi, yellow gourd, chrysanthemum, kikunigana Gelia africana, aloe vera, mint, cinchona, quinoa, yellowfin (a.k.a. bark), amberjack, yellow-pink lupine, millet, gymnema, yellow magnolia, cassava, cabbage, caraway, cucumber (a.k.a. cucumber), cucumber, cucumber, cucumber , Quillaja, Kiri, Myrtle (a.k.a. Honeysuckle), Guar, Guava, Quinceseed, Cuercas Alba, Cucuinoki,

Wolfberry, celandine, kudzu, camphor tree, kudamonopassiflora, gardenia, quail, kumazasa, vervain, anemone, cumin, cramelia triandra, clara, grandberry, cristum maritimum, grinderia robusta, Clintonia borealis, woodruff, walnut, Grapefruit, clematis, black mustard, black walnut, kuroban vine, glove, black currant, black mulberry, mulberry, turmeric, cay (also known as cinnamon), gem urbanum, gem liverale, cape aloe, poppy, geckavidin, bay, alpinia, gentian, gentian prostrata , Gennoshoko, Kenponashi, Kouki, Koukitan, Koukiten, Koubou, Kobo, Kouhone, Coffee tree, Scutellaria baicalensis, Coccinia indica, Ebony, Cochlearia officinalis, Bilberry, Coconut palm, Gosho strawberry, Pepper, Coconut palm, Cochineal cactus, Phalaenopsis, Phalaenopsis, Quercus, Chickweed, Burdock, Sesame, Wheat, Rice, Tickle, Coriander, Coleus, Coleus Barbatus, Carambola, Fenugreek, Conzlango, Comfrey (also known as Comfrey), Combretum micrantham, Sisal hemp, Cycin, Cyperus esculentus, Cypress, Hempberry, South Rare Involucurata, Sakishima Kanbokuri, Sakura, Sakuraba Kamboku, Pomegranate, Sugar Maple, Sugar Cane, Sugar Pine, Camellia, Sassafras Unedo, Saffron, Soap Soap, Salix Nigra, Salix Nigra, Lagerstroemia, Sanguinaria Canadensis, Hawthorn, Sanshiki Violet , Sanshichin carrot, Japanese cornel, Sansho, Sanpenz,

Siate medularis, Cyanothis arachnoidea, Shea tree, Shiozakisou, Shicymbrium ilio, Cistrose (aka Labdanum), Cistus monsperiensis, Cistus sladaniferus, Shiso, Shichihenge, Linden, Wheatgrass, Dypteryx odorata , Siberian fir, simalva, mishishifugadafurika, meadowsweet, potato, peony, jasmine, janohige, janomeerica, shukusha, juzdama, gypsophila paniculata, junipers mexicana, juniper, ginger, shozuku (also known as cardamom), calamus, shoyou Rhubarb, Birch, Birch, White Mustard, White Birch Indian Soba, White Bana Lupine, White Birch Cotton, Cinchona Calisaya, Synsepalm dursificum, Cymbidium, Symprocosracemosa, Sweet Acacia, Watermelon, Honeysuckle, Scabiosa Arvensis, Horsetail, Scutellaria Galle Ricurata, Stevia, Pinus strobus, Spiny bamboo, Spirulina platensis, Spirulina maxima, Purslane, Spelt, Aristolochia aephoria, Smilax madder, Scotch pine, Isonoki, Stinging nettle, Plantain, St. John's wort, valerian, squash, medlar, kawara carrot, ivy, walnut, scrophulariaceae, primrose, hawthorn, linden, white willow, dandelion, boxwood, horse chestnut, ash, pear, dayflower ,

Rowan, Ceylon cinnamon, Sambucus nigra, Carrot, Juniper, Yarrow, Hazel, Mentha, Holly, Black cherry, Lotus japonicum, Barberry, Mistletoe, Blackberry, Blackberry, Sage, Cecropia Bushifolia, redwood, cecil oak, sedum purpurea, mallow, senega, geranium, cersidium floridum, cereus grandiflorus, celery, cnidium, centifolia rose, centipeda kunningami, sennin koku, sempukuka, assembly, Sojutsu, Saw Palmetto, Jasminum, Buckwheat, Solanum Licocarpum, Daifennel, Japanese Radish, Daisanchiku, Soybean, Citrus daidai, Astragalus membranaceus, Thyme, Taiwan cypress, Takasaburo, Tachibana, Tachibana, Tabunoki, Tabebuia avellanedae, Tamasakitsutsurafuji, Damask rose , onion, damiana, tarragon, tangine, tambourissa tricophila, tygaya, tea (tea), passionflower, tuberose, clove, culinary artichoke, butterfly bean, chilia tomentosa, horsetail camellia, centella asiatica, thrush, thoracic tufted flower, mongrel, tea Tree, Dioscorea composita, Dioscorea virosa, Dioscorea mexicana, Teuchi walnut, Tecoma clearis, Tetsuzainoki, Duke, Deboisia leicardochi, Terminalia, Tencha, German iris, German spruce, Pepper, Capsicum, Angelica, Tou Calendula, Ligustrum, Spruce, Corn, Milkweed, Horsetail, Houttuynia cordata, Dokunin ginseng, Toshishi (a.k.a. Mamedaoshi), Juniper, Tomato, Trigonella foenum, Tormentilla,

Tororo-aoi-modoki, Long-haired snipe, Rhododendron squid, Eggplant, Shepherd's purse, Jack bean, Feverfew, Natsubodaju, Jujube, Date palm, Anthraphyllum, Nanbanai, Nanbanksafuji, Scented violet, Scented mulberry, Scented cedar, Wormwood, Nikuzuku, Nigella sativa, Nyukouju, Leek, Carrot, Garlic, Nymphaea alba, Cuscuta, Noibara, Trumpet Hallen, Noji violet, Wild rose, Pinecone, Pineapple, Hibiscus, Stone pine, Baobab, Bakuhoshia triodora, Bakumondou, Bacopa monniera, Hagoromo grass, Lotus, Parsley, Patchouli, Mentha cucumber, Bakkali Sgenysteroides, Passiflora alata, Coix seed, Banana, Banana, Honeysuckle, Vanilla, Vanilla tahitensis, Hanesenna, Papaya, Paphiopedilum maudiae, Haverrealodopensis, Hamanasu, Hamamelis, Chayote, Rose, Parietaria, Rosie , Harpagophytum, Palmarosa, Barosma beturina, Banturum, Pansy, Bambara bean, Beet, Holly barberry, Lily lily, Cornflower, Visnagabera, Bitter almond, Bitter orange, Hydrastis canadensis, Daisy, Corn poppy, Vinangka vine, Pinus heda, Cypress, Fucus, Holly daisy, Hippo Fae rhamnoides, sunflowers, red-faced koji, white-collar, periwinkle, hymenaea curvalil, white-fleur, sandalwood, chickpeas, lentils, comfrey, lily lily, Pyrocarpus pennatihorius, loquat, betel nut, Phaffia paniculata, velvet, pueraria mirifica , Ferula galvaniflua, Coltsfoot, Bucuri, Fusazaki daffodil, Red currant, Fusa lily of the valley, Fusanus spicatus, Petit grain, Petit copetalum oracoides, Bushouge, Butcher bloom, Pterocarpus marspium, Grape, Myrtaceae, Beech, Fuyuzansho , Fuyubodaiju, Fragaria chiroensis, Brazil nut tree, French kaigansho, French lavender, Plantago afra, Plantago obata,

Plantagopsilium, Primulus cymensis, Prune, Prunus africana, Prunus serotina, Plumeria, Plectranthus barbatus, Bretschiacinthina, Bay, Hayflower, Hazelnut, Pecan, Vetiver, Loofah, Pennyroyal mint, Bixa, Safflower , Safflower assembly, Cucurbita pepo, Hela plantain, Pelargonium capitatum, Helichrym arenarium, Helichrym angustifolium, Helichrym italicum, Bergamot, Peltholm da silatis, Peruvian balsam, Bergamot, Berberis aquifolium, Veronica officis Naris, Henna, Rhubarb, Broom, Boshuboku, Boshunka, Garden Balsam, Spinach, Spinach, Hawkweed, Magnolia, Hokubei Owl, Boco Apurou Ascensis, Boswellia serrata, Hosoba Senna, Hosoba Barangiku, Bodaiju, Botan, Hop, Poterium officinale, Jojoba , polygonatum multiflorum, boldo, poncan, macadamia, magnolia officinalis, magnoliabionji, muguwa, magojakushi, masaki, madake, pine, matsurika, matecha, madonna lily, majorana, marian thistle, malpighia glabra, quince, Horse chestnut, Mango, Mangosteen, Scotch pine, Tagetes, Mandarin orange, Mandrake, Spicy rhizome, Peppermint, Water lemon, Michiyanagi, Honeysuckle, Mitracarpus skaver, Mimosa tenuiflora, Myrciaria dubia, Myrrh (aka Motsuyakuju), Myrothamnus fura Bellifolia, Myrobalan, Sapindacteria, Murasaki, Murasakishikibu, Murasaki assembly, Murasaki balensis, Muraya koenji, Japanese basil, evening primrose, Melia azadirachta,

Melissa (a.k.a. Kousuimint), Melilot, Melosuria, Melon, Mentha Arvensis, Mugwort, Mourela Fulvia Chillis, Magnolia, Moscatabara, Moss Bean, Motsuyakuju, Peach, Momotamana, Yakumoji, Cornflower, Yashabushi, Willow, Willow mint, Willow herb, Yamaguwa, Yamazakura, Yamanoimo, Japanese mugwort, Yugao, Eucalyptus, Eupatorium ayapana, Eupatorium rebaudianumbertoni, Yukinoshita, Yuzu, Yusouboku, Yucha, Yucca glauca, Yucca schidigera, Lily, Youshutsurukinbai, Youshuhozuki, Youshu Wild pokeweed, European goldenrod, European raspberry, European chestnut, European black aspen, European white birch, European beech, European stonecrop, European fir, mugwort, mugwort, lychee (also known as litchi), lima bean, lime, rye, lilac, radiata pine, ratania, Peanut, Ranunculus ficaria, Lavandula hybrida, Rafuma, Lavender, Larix europaea, Larea divaricata, Lalea mexicana, Rambutan, Lithosamnium calcalum, Lithocea glutinosa, Longan, Lirios maobacica, Apple, Rooibos, lupine subbucarnosus, rubus birossus, lumpuyan, borage, borage, respedeza, lesedalteola, lettuce, redama, redum palustre, lebanese cedar, lebisticum officinale, lemon, lemongrass, astragalus, rosewood, rosemary, rhubarb Plants such as bush blueberry, Roman chamomile, laurel (a.k.a. laurel), logwood, coffee robusta, wild thyme, horseradish, horseradish, moringa, cotton oak, cotton wisteria, walteria indica, burnet;

Ascofilm nodosum, Aname, Oukimo, Okinawa Mozuku, Gigaltina stellata, Kugermaniella girata, Sargassum filipendula, Sargassum fushiforum, Sargassum muticum, Sphaceraria scoparia, Durvillea antarctica, Padina pavonica, Himantaria elongata, Fucus ceratus, Pervechia canaryculata, Macrocystis spirifera, Mitsuishi kelp, Laminaria ochlorica, Laminaria croustoni, Laminaria digitata, Laminaria hyperborea, Wakame seaweed, Asparagopsis armata, Aegis, Kagiibaranori , Katamen Eucheuma, Gelidium Cartilagineum, Cymi, Shimatengusa, Dullus, Chinolimo, Tochaka, Porphyridium Cruentum, Marbachishima Chronori, Lythossumnium Coralarioides, Anaaosa, Chlorella Emersoni, Chlorella pyrenoidosa, Dunaliella salina , Dunaliella bardawill, Gila green algae, Spirulina platensis, Spirulina maxima, Hasslea Ostrella, Derecelia sanguinea, Piquea robusta, Pleurochrysis cartere, Haematococcus pluvialis, Cyanobacteria, Condors crispus, Coralline algae, Sea whip, Red algae such as algae;

Examples include lichens and mycelium such as Ebernia furfuracea, Pleurotus thunbergii, Usnia barbata, Oshagujitake, Kabananatake, Shiitake, Ningyotake, Himematsutake, Fuyumushinatsutake, Kavaanatake, Choreymaitake, Cordyceps, and the like.

The amount of the plant-derived extract is not particularly limited. The amount of the extract to be blended is preferably 0.1 to 1,000 parts by mass, more preferably 0.5 to 200 parts by mass, most preferably 1 to 100 parts by mass, per 100 parts by mass of component (A).

Examples of zinc compounds include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undecylenate, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, and polypyrrolidonecarboxylic acid. zinc, organic acid zinc salts such as zinc picolinate; zinc sulfonates such as zinc p-phenolsulfonate, zinc ascorbyl phosphate, sodium zinc cetyl phosphate, zinc phosphates such as DNA zinc; zinc complexes such as zinc pyrithione (silver/zinc/ammonium) zeolite, zinc-supported zeolite such as silicic acid (ammonium/silver/zinc/aluminum); aluminum hydroxide such as aluminum oxide/zinc, aluminum oxide/zinc/cerium, aluminum oxide/zinc/iron Baked products such as zinc sulfate, zinc sulfide, zinc chloride, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, zinc potassium sulfate, zinc iodide, basic zinc carbonate and other inorganic zinc salts; /carbonic acid) (Mg/Al/zinc), zinc oxide, and the like. Among these, compounds that easily dissolve in water to form zinc ions are preferred, and the solubility in 100 g of water at 20° C. is preferably 5 g or more, and more preferably 10 g or more. Such zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, zinc potassium sulfate, zinc iodide, and the like.

The amount of zinc compound is not particularly limited, but if the amount of zinc compound is too small, the effect of improving antibacterial properties may not be obtained. The amount is preferably 0.02 to 10 parts by mass, more preferably 0.05 to 5 parts by mass, most preferably 0.1 to 2 parts by mass, per 100 parts by mass of component (A).

Among these, the synergistic effect of the components (A) and (B) enhances the antibacterial effect, so the antibacterial composition of the present invention contains a chelating agent and a low-molecular-weight polyol as the component (C). (excluding diol compounds corresponding to component A)), and nitrogen-containing nonionic surfactants. It is more preferable to contain one or more compounds selected from the group consisting of

The antibacterial composition of the present invention exhibits a high antibacterial effect not only in a uniform aqueous solution but also in an emulsified system. A W/O/W emulsion or a type thereof may be used. Moreover, the antibacterial composition of the present invention has a high antibacterial effect against not only bacteria but also fungi such as molds.

The use of the antibacterial composition of the present invention is not particularly limited, and it can be used in the same manner as known antibacterial agents, disinfectants, disinfectants, and antifungal agents for the purpose of antibacterial, sterilization, disinfection, antifungal, etc. can. For example, a method that is usually employed, such as a method of spraying an object to be antibacterially treated, a method of coating, a method of impregnating an object, a method of immersing an object, etc., can be used as they are. In addition, the antibacterial composition of the present invention can be used as a medical cleaning agent for the purpose of disinfecting and cleaning medical instruments and affected areas, a household cleaning agent for sterilizing and cleaning tableware, a cleaning agent for the food industry, and a container transfer. Lubricants for conveyors, food packaging films, fibers, synthetic resins, wood, antibacterial agents for antibacterial processing of daily necessities, etc., body cleansers, cosmetics, fabric softeners, water-based or non-water-based paints, non-woven fabrics, etc. When used as a wet tissue, a toilet seat cleaner, or an antibacterial agent for fibers, all fibers such as cotton, polyester, acrylic, nylon, etc. can be treated by general methods such as stirring, immersion, and spraying. The antibacterial composition of the present invention can also be applied or sprayed onto the surfaces of wood, daily necessities, and the like. Furthermore, when used for synthetic resins, etc., the antibacterial composition of the present invention may be adhered to the surface by coating or spraying after molding, or it may be kneaded during molding or the like in order to maintain the antibacterial effect. can also Among these, the antibacterial composition of the present invention is highly safe for the human body, so it is preferably used in cosmetics, body cleansers, and other products that come into direct contact with the human body. It is more preferable to use it for agents.

Examples of cosmetics in which the antibacterial composition of the present invention can be preferably used include, for example, shampoos, dry shampoos, rinse-integrated shampoos, hair rinses, hair conditioners, hair packs, hair treatments, hair tonics, and pomades. , hair cream, hair wax, hair gel, hair foam, hair mousse, hair mist, hair lotion, permanent wave agent, hair care cosmetics such as hair dye; Soap, body soap, body lotion, sunscreen, lotion, milky lotion, serum, face cream, cold cream, face pack, antiperspirant, shaving soap, shaving foam, shaving oil, shaving lotion, aftershave lotion, aftershave skin care cosmetics such as sun lotion; make-up cosmetics such as foundation, concealer, face powder, blusher, mascara, eyeliner, and eyeshadow; lip balm, bath powder, and the like.

Cosmetics containing the antibacterial composition of the present invention may contain surfactants commonly used in cosmetics. Examples of such surfactants include anionic surfactants, cationic surfactants, nitrogen-free nonionic surfactants, and the like.

Examples of anionic surfactants include higher fatty acid salts, higher alcohol sulfates, sulfated olefin salts, higher alkylsulfonates, α-olefinsulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, phosphoric acid Ester salts, fatty acid ester sulfate salts, glyceride sulfate ester salts, fatty acid ester sulfonates, α-sulfo fatty acid methyl ester salts, polyoxyalkylene alkyl ether sulfate salts, polyoxyalkylene alkylphenyl ether sulfate salts, poly Oxyalkylene alkyl ether carboxylates, acylated peptides, fatty acid alkanolamides or alkylene oxide adducts thereof, sulfuric acid ester salts, sulfosuccinic acid ester salts, alkylbenzene sulfonates, alkyl naphthalene sulfonates, alkyl benzimidazole sulfonates, Polyoxyalkylene sulfosuccinate, N-acyl-N-methyltaurine salt, N-acylglutamic acid or its salt, acyloxyethanesulfonate, alkoxyethanesulfonate, N-acyl-β-alanine or its salt, N -acyl-N-carboxyethyl taurine or its salt, N-acyl-N-carboxymethylglycine or its salt, acyl lactate, N-acyl sarcosine salt, alkyl or alkenyl amino carboxymethyl sulfate and the like. Counter ions of such anionic surfactant salts include alkali metal ions such as lithium, sodium and potassium; alkaline earth metal ions such as calcium and magnesium; ammonium; monoethanolammonium, diethanolammonium and triethanolammonium. , monoisopropanolammonium, diisopropanolammonium and triisopropanolammonium.

Examples of cationic surfactants include amine-based surfactants such as alkyldimethylamine, alkenyldimethylamine, fatty acid dimethylaminopropylamide, and fatty acid diethylaminoethylamide; alkyltrimethylammonium salts, alkenyltrimethylammonium salts, and alkyldiethanolammonium salts. , alkenyldiethanolammonium salts, alkyldimethylbenzylammonium salts, alkenyldimethylbenzylammonium salts, dialkyldimethylammonium salts, alkyldiethanolammonium salts, alkylpyridinium salts, 3-alkoxy-2-hydroxypropyltrimethylammonium salts, polyoxypropylenemethyldiethylammonium salts. Ammonium salt-based surfactants such as salts can be mentioned. Examples of the counter ion of the ammonium salt-based surfactant include chloride ion and bromide ion.

Nitrogen-free nonionic surfactants include, for example, polyoxyalkylene alkyl ethers, polyoxyalkylene alkenyl ethers, and polyoxyethylene polyoxypropylene alkyl ethers (addition forms of ethylene oxide and propylene oxide are random or block-like). any), polyethylene glycol propylene oxide adduct, polypropylene glycol ethylene oxide adduct, glycerin fatty acid ester or its ethylene oxide adduct, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkyl polyglucoside, sucrose fatty acid ester, alkyl (Poly)glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid methyl ester ethoxylate, and the like.

Cosmetics and detergents containing the antibacterial composition of the present invention may contain, in addition to the surfactant component described above, other components, such as silicone oil, thickener, oil agent, etc., as long as they do not impair the object of the present invention. Powders (pigments, dyes, resins), other antibacterial agents, fragrances, moisturizers, bioactive ingredients, salts, solvents, antioxidants, chelating agents, pearling agents, neutralizers, pH adjusters, enzymes, etc. Ingredients can be blended as appropriate.

Thickeners include, for example, dimethyldiallylammonium chloride/acrylamide copolymer, acrylamide/acrylic acid/dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar , gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high-methoxyl pectin, low-methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, beta-glucan, gellan gum , dextran and the like.

Oils include volatile and non-volatile hydrocarbons, higher alcohols, medium- to high-chain fatty acids and their esters, fats and oils, etc., which are commonly used in cosmetics, and may be liquid, paste, or solid at room temperature. However, liquids that are easy to handle are preferred. Oil agents include, for example, higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, and octyldodecanol; fatty acids such as isostearic acid, undecylenic acid, and oleic acid; myristyl myristate, hexyl laurate, and oleic acid; Decyl, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate and other esters, liquid paraffin, vaseline, squalane and other hydrocarbons, lanolin, reduction Waxes such as lanolin and carnauba wax, oils and fats such as mink oil, cacao butter, coconut oil, palm kernel oil, camellia oil, sesame oil, castor oil and olive oil.

Examples of powders include pigments such as Red No. 201, Yellow No. 4, Blue No. 1 and Black No. 401, lake pigments such as Yellow No. 4 Al lake and Yellow No. 203 Ba lake, nylon powder, silk powder, and silicone powder. , Cellulose powder, Silicone elastomer spherical powder, Polymers such as polyethylene powder, Yellow iron oxide, Red iron oxide, Chromium oxide, Carbon black, Ultramarine blue, Prussian blue and other colored pigments, Zinc oxide, Titanium oxide and other white pigments, Talc , extender pigments such as mica, sericite, and kaolin; pearl pigments such as titanium mica; metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, and magnesium silicate; inorganic powders such as silica and alumina; bentonite, smectite, and boron nitride. etc. The shape of these powders (spherical, rod-like, needle-like, plate-like, amorphous, scaly, spindle-like, etc.) is not particularly limited.

These powders are subjected to conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil treatment, N-acylated lysine treatment, poly It may be surface-treated in advance by acrylic acid treatment, metallic soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment, or the like.

Other antibacterial agents include, for example, paraben antibacterial agents such as methylparaben and ethylparaben; imidazole antibacterial agents such as thiabendazole, methyl 2-benzimidazolylcarbamate and imidazolidinyl urea; trichlorocarbanilide, cloflucarban and the like. carbanilide antibacterial agents; thiazole antibacterial agents such as benzothiazole; triazine antibacterial agents such as debuconazole and kavinon; biguanide antibacterial agents such as chlorhexidine hydrochloride and polyhexamethylene biguanide; When used, it should be used with caution, taking into consideration the irritation to the human body.

Examples of moisturizing agents include diethylene glycol monoethyl ether, deoxyribonucleic acid, mucopolysaccharides, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, biopolymers such as hydrolyzed eggshell membranes, amino acids, sodium lactate, Urea, sodium pyrrolidonecarboxylate, betaine, whey and the like.

Examples of solvents include purified water, ethanol, light liquid isoparaffin, lower alcohols, ethers, LPG, fluorocarbons, N-methylpyrrolidone, fluoroalcohols, next-generation freon and the like.

EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples. In the following examples and the like, "%" and "ppm" are based on mass unless otherwise specified.

<Compounds used in the experiment>
(A) Component A1: 1,2-pentanediol A2: 1,2-hexanediol A3: 1,2-octanediol A4: 1,2-decanediol (B) Component B: benzyloxyethanol

(C) Component C1: 4Na glutamate diacetate
C2: glycerin C3: coconut fatty acid monoethanolamide (cocamide MEA)
(D) Component D1: Phenoxyethanol D2: Methylparaben D3: Glyceryl caprylate

Antibacterial agents of Examples 1 to 10 having compositions shown in Table 1 and Comparative Examples 1 to 18 shown in Table 2 were prepared using the above compounds. The numbers in Tables 1 and 2 are % by mass. Moreover, Example 1 is a reference example.

<Bacteria used in the experiment>
B.cep: Burkholderia cepacia (bacteria)
P.aer: Pseudomonas aeruginosa (bacteria)
A.bra: Aspergillus brasiliensis (fungus)

Formulations 1 and 2 were prepared with the following formulations. There are two types of antibacterial agents, 0.4% by mass and 0.8% by mass. 0.8% by weight was used in tests against A.bra. Formula 1 is a skin cream formula, formula 2 is a conditioner formula, and both emulsifying systems are O/W emulsions.

<Prescription 1: Skin cream>
Triethylhexanoin 20% by mass
Sorbeth tetraoleate-30 4% by mass
Cetearyl alcohol 0.2% by mass
Glycerin 0.2% by mass
(Acrylates/alkyl acrylate (C10-30)) crosspolymer 0.1% by mass
Antibacterial agent 0.4% by mass or 0.8% by mass
Sodium hydroxide appropriate amount (adjusted to pH 6.0)
water

<Prescription 2: Hair conditioner>
Stearyl alcohol 1.0% by mass
Behentrimonium chloride 0.5% by mass
Cetanol 0.5% by mass
Amodimethicone 0.5% by mass
Antibacterial agent 0.4% by mass or 0.8% by mass
water

20 g of formulation 1 or formulation 2 and 0.2 mL of a bacterial solution with a bacterial concentration of 1.0×10 ⁸ cfu/mL are placed in a sterilized 30 mL glass bottle with a lid and mixed uniformly. The glass bottle was stored in a constant temperature bath at 25 ° C., B.cep and P.aer were sampled after 2 days and 7 days, A.bra was sampled after 7 days and 28 days, and the viable cell count concentration (unit: cfu / mL) was measured, and the antibacterial activity value was calculated by the following formula. A higher antibacterial activity value indicates higher antibacterial activity. The results using Formulation 1 are shown in Tables 3 and 4, and the results using Formulation 2 are shown in Tables 5 and 6.
Antibacterial activity value = 6-Log (concentration of viable count (cfu/mL))

When A1, A2, A4 and B1 were used alone, Formulations 1 and 2 showed little antibacterial activity. When A3 was used alone, antibacterial activity was observed against bacteria (B.cep, P.aer), but no antibacterial activity against fungi (A.bra) was observed. The antibacterial composition of the present invention, which uses the components (A) and (B) in combination, exhibits high antibacterial properties not only against bacteria but also against fungi, and the synergistic effect of the components (A) and (B). It turns out that there is Moreover, the addition of the component (C) further improved the antibacterial properties.

Claims (6)

An antibacterial composition containing a diol compound represented by the following general formula (1) as a component (A) and benzyloxyethanol as a component (B).

(In the formula, ^R1 represents a butyl group, a hexyl group or an octyl group .) 2. The antibacterial composition according to claim 1, wherein the mass ratio of component (A) and component (B) is 10:90 to 90:10. Furthermore, as component (C), chelating agents, low-molecular-weight polyols (excluding diol compounds corresponding to component (A)), nitrogen-containing nonionic surfactants, nitrogen-containing amphoteric surfactants, plant-derived extracts and zinc compounds 3. The antimicrobial composition according to claim 1 or 2, containing one or more components selected from the group consisting of: The antibacterial composition according to any one of claims 1 to 3, which is used for preserving cosmetics. A cosmetic containing the antibacterial composition according to any one of claims 1 to 4. A method for imparting antibacterial properties to a cosmetic, comprising adding a diol compound represented by the following general formula (1) (component (A)) and benzyloxyethanol (component (B)) to the cosmetic.

(In the formula, ^R1 represents a butyl group, a hexyl group or an octyl group .)