JP7154840B2 - PTP sheet package - Google Patents

Description

The present invention relates to a push-through pack (hereinafter referred to as " PTP ") sheet containing tablets or capsules.

A PTP sheet is known as a packaging technology for medicine tablets. The PTP sheet has a plastic molded body made of synthetic resin, and the plastic molded body has a projecting portion having a space for accommodating a tablet and a flat plate portion formed on the peripheral edge of the projecting portion. A breakable sheet such as aluminum foil is attached to the surface of the molded plastic molded body opposite to the projecting portion to seal the tablet in the space of the projecting portion. When taking out the tablet from the PTP sheet, the protruding part is pressed with a finger to press the tablet against the sheet to break the sheet, and the tablet is taken out from the broken part.

In order to convey information such as dosing timing and precautions to a patient who takes medicine, it is known to attach a package containing the information so as to sandwich a PTP sheet (for example, see Patent Document 1). 3).

JP 2015-101393 A Japanese Patent Application Laid-Open No. 2007-330401 JP 2006-248545 A

The packages described in Patent Literatures 1 to 3 are coated with an adhesive on mating surfaces and adhered to the sandwiched PTP sheets. If the adhesive is exposed during the manufacturing process or storage of the packages, the packages may stick to each other when the packages are stacked. In order to prevent this, the adhesive layer may be covered with a release paper or the like until use, but this requires a step of attaching and removing the release paper, making handling complicated.

In view of the above circumstances, an object of the present invention is to provide a PTP sheet package that can suppress sticking during the manufacturing process and storage without using a release paper or the like.

The present invention is a PTP sheet package in which a PTP sheet is sandwiched between PTP sheet card packages having a first region having a plurality of openings and two regions having a plurality of openings and connected to the first region. is the body .
The first region and the second region are formed of sheet material. The sheet material has a substrate and a pressure-sensitive adhesive layer made of a pressure-sensitive adhesive and provided on one surface of the substrate. A pressure sensitive adhesive layer is formed on both the first region and the second region. In this PTP sheet card package, the peel force when the first region and the second region are joined with the pressure-sensitive adhesive layer facing each other is 4 of the peel force when the pressure-sensitive adhesive layer of the PTP sheet card package is bonded to the surface opposite to the surface on which the pressure-sensitive adhesive layer is provided in the base material of the lower PTP sheet card package more than double.
The PTP sheet card package has a display window at a position where neither the storage portion for the PTP sheet nor the back side of the storage portion is arranged, and a portion of the PTP sheet is visible through the display window.

ADVANTAGE OF THE INVENTION According to this invention, the PTP sheet package which can suppress the sticking at the time of a manufacturing process or storage, even if it does not use release paper etc. can be provided.

BRIEF DESCRIPTION OF THE DRAWINGS It is a figure which shows the card packaging body for PTP sheets which concerns on 1st embodiment of this invention. FIG. 4 is a schematic cross-sectional view of a sheet material forming the PTP sheet card package. It is a figure which shows the card|curd packaging body for PTP sheets which concerns on 2nd embodiment of this invention. FIG. 4 is a schematic cross-sectional view of a sheet material forming the PTP sheet card package.

A first embodiment of the present invention will be described with reference to the drawings.
FIG. 1 is a diagram showing a PTP sheet card package (hereinafter sometimes simply referred to as "package") 1 of the present embodiment. The package 1 is made of a sheet material, and has a configuration in which a first region 10 and a second region 20 are connected at a boundary line 30 .

FIG. 2 shows the layer structure of the sheet material 100 forming the package 1. As shown in FIG. The sheet material 100 comprises a substrate 101 and a pressure sensitive adhesive layer 102 formed on the substrate 101 . The thickness of the sheet material 100 can be set appropriately. For example, it is 200-500 μm, preferably 250-400 μm.
The material of the base material 101 can be appropriately selected according to the application. rigid resins such as polystyrene) and PA (polyamide) can be exemplified.

Pressure-sensitive adhesive layer 102 is formed of a pressure-sensitive adhesive. Pressure-sensitive adhesives do not exhibit strong tackiness unless pressure of a predetermined value or more is applied. As a result, even if the pressure-sensitive adhesive layer 102 is exposed during storage or during the manufacturing process, sticking or the like is less likely to occur. As the pressure-sensitive adhesive, various adhesives such as acrylic, urethane, silicone, and rubber can be used.
The pressure sensitive adhesive of this embodiment contains rubber latex in the base. Examples of rubber latex include acrylic modified natural rubber latex, peroxide pre-vulcanized latex, styrene-butadiene rubber latex, acrylonitrile-butadiene rubber latex, butadiene rubber latex, chloroprene rubber latex, urethane rubber latex and the like. These rubber latexes may be blended in any weight ratio to form the base.
The pressure sensitive adhesive may optionally contain an antiblocking agent. Antiblocking agents include, for example, calcium bicarbonate, light calcium carbonate, talc, metal soap stearate, starch, silica and the like.

The first region 10 and the second region 20 have the same shape and size, and have the same number of openings 2, respectively. The shape and dimensions of each opening 2 are set so that the protrusion of the PTP sheet to be accommodated can pass through. The shape of the opening 2 can also be set to an arbitrary shape such as a circular shape, a rhombic shape, or a rectangular shape with rounded corners. The opening 2 can be formed using a pinnacle die (corrosion blade), a Thomson blade, or the like formed in an arbitrary shape.
In the first region 10, in addition to the opening 2, a display window 3 is formed for visually recognizing a portion of the wrapped PTP sheet. The display window 3 can be formed in the same manner as the opening 2. FIG.

There is no particular limitation on the form of the boundary line 30, and folding lines, perforations, half-cut lines, and the like can be exemplified. In the case of perforations and half-cut lines, similar to the opening 2, they can be formed with a pinnacle die, a Thomson blade, or the like.
When the package 1 is folded along the boundary line 30, the first area 10 and the second area 20 completely overlap. Furthermore, the openings 2 formed in the first region 10 and the second region 20 correspond one-to-one and overlap concentrically.

The package 1 of the present embodiment accommodates a PTP sheet containing an investigational drug and a PTP sheet containing a placebo, so that the subject does not know which one has been administered. Therefore, the base material 101 is made of paper so that the accommodated PTP sheet cannot be visually recognized and various information can be written by medical personnel. The PTP sheet may be printed with a code that can be understood only by a doctor and indicates whether the drug is an investigational drug or a placebo.

The operation of the package 1 of this embodiment configured as described above during use will be described. Since the pressure-sensitive adhesive layer 102 of the package 1 is made of a pressure-sensitive adhesive, the pressure-sensitive adhesive layer 102 is always exposed without being covered with a release paper or the like.

The packages 1 are stacked in the thickness direction and stored until the PTP sheets are packaged. Therefore, in a plurality of stacked packages 1, the pressure-sensitive adhesive layer 102 is in contact with the base material 101 of other packages 1. As shown in FIG.
Although the details will be described later, in the package 1, the peeling force (amount of force required to peel off each other) when the pressure-sensitive adhesive layers 101 made of a pressure-sensitive adhesive are opposed and bonded to each other is the pressure-sensitive adhesive. It is four times or more the peel force when the layer 102 and the base material 101 are brought into contact and pressed with a predetermined force. Therefore, even if a plurality of packages 1 are stacked and stored with the pressure-sensitive adhesive layer 102 exposed, the packages 1 do not adhere firmly to each other and can be easily removed without damaging the base material 101 . In the combination of the rubber latex-based pressure-sensitive adhesive and the paper substrate in this embodiment, the release force when the pressure-sensitive adhesive layer 102 and the substrate 101 are brought into contact with each other and pressed with a predetermined force is, for example, When a load of 2000 g, which is equivalent to the load applied to the bottom package when 1000 bodies 1 are stacked, is 0.2 N/25 mm or less, it can be removed with a very small force.

The peel force when the pressure-sensitive adhesive layers 102 are opposed to each other and bonded is 2 N/25 mm or more, preferably 4 N/25 mm or more. If the thickness is 2 N/25 mm or more, even if the packaging body 1 bonded with the PTP sheet sandwiched therebetween is subjected to a shock, it hardly peels off, and the subject's blind state is preferably maintained. If the peel force is 4 N/25 mm or more, the substrate 101 will be destroyed if the bonded surface is forcibly peeled off, leaving traces of peeling, which can be easily confirmed by a doctor or the like.

Peel force can be measured with any tensile tester. For example, a sample in which two sheet-like materials 100 are bonded via a pressure-sensitive adhesive layer 102 is prepared, and a precision universal testing machine (for example, Autograph AG-Xplus manufactured by Shimadzu Corporation) is used to test at a test speed of 300 m / It can be measured by performing T-shaped peeling of the sample at min. When the base material 101 is destroyed without peeling in the pressure-sensitive adhesive layer 102 or at the interface, the value of the resistance to destruction is defined as peeling force.

A PTP sheet that matches the position and dimensions of the opening 2 is positioned on the adhesive layer 102 side so that the protrusion protrudes from the opening 2 of the first region 10 . When the package 1 is folded so that the pressure-sensitive adhesive layers 102 face each other along the boundary line 30 and the first region 10 and the second region 20 are joined, the PTP sheet is covered with the package 1 . At this time, the protrusion of the PTP sheet protrudes from the opening 2 of the first area 10, and the aluminum sheet or the like behind the protrusion is exposed through the opening 2 of the second area 20 so that the user can access it.

The user can take out the drug contained in the PTP sheet by breaking the exposed aluminum sheet or the like. On the other hand, the printing of the PTP sheet is concealed so as not to be visually recognized by the user except for the code visible through the display window 3, and the blindness is preferably maintained.

As described above, since the PTP sheet card package 1 according to the present embodiment is formed of the sheet material 100 having the pressure-sensitive adhesive layer 102, sticking or the like is prevented before being attached to the PTP sheet. It is less likely to occur, and the complexity of handling is reduced. Furthermore, there is no need to cover the pressure-sensitive adhesive layer 102 with release paper or the like until use, which contributes to a reduction in manufacturing costs and waste.

A second embodiment of the present invention will be described with reference to FIGS. 3 and 4. FIG. In the following description, the same reference numerals are given to the same configurations as those already described, and duplicate descriptions will be omitted.

FIG. 3 is a diagram showing the package 51 of this embodiment. The openings 52 provided in the first area 10 and the second area 20 are sized so that two protrusions of the accommodated PTP sheet can pass through.

A printing section (information section) 53 for displaying information for the user is provided on the surfaces of the first area 10 and the second area 20 . In the example shown in FIG. 3, cautions when taking medicine, timing of taking medicine, etc. are shown as information, but patterns other than characters may be used.
The printing portion 53 can be formed with ink in which a coloring agent is dispersed in a resin such as acrylic or cellulose. As the coloring agent, inorganic pigments (titanium oxide, carbon black, copper, etc.), pearl pigments, aluminum powder, and the like can be used. Although the method of forming the printing portion 53 is not particularly limited, for example, a planographic printing method (offset printing, etc.), an intaglio printing method (engraving intaglio printing, gravure printing, etc.), or a stencil printing method (silk screen printing, etc.) can be used. .
The thickness of the printed portion 53 is also not particularly limited, but can be, for example, in the range of 0.5 μm to 10 μm, more preferably in the range of 1 μm to 3 μm.

FIG. 4 is a schematic cross-sectional view of the sheet material 100A forming the package 51. As shown in FIG. The pressure-sensitive adhesive layer 102A of this embodiment is formed of a pressure-sensitive adhesive that does not have a rubber latex base. The printed portion 53 is formed on the second surface 101b of the substrate 101 opposite to the first surface 101a provided with the pressure-sensitive adhesive layer 102A.

The print portion 53 is covered with a release layer 103 . In this embodiment, the release layer 103 constitutes the surface of the base material 101 on the side of the second surface 101b, and reduces the release force when the pressure-sensitive adhesive layer 102A contacts.
The release layer 103 can be formed using a silicone release agent or a non-silicone release agent such as a fluorine release agent. The method of forming the release layer is not particularly limited, and examples include letterpress printing methods (letterpress printing, flexographic printing, etc.), planographic printing methods (offset printing, etc.), and intaglio printing methods (engraving intaglio printing, gravure printing, etc.). can be done using The thickness of the release layer is also not particularly limited, but may be, for example, 0.5 to 10 μm, preferably 1 to 5 μm. The release layer 103 may be formed on the entire second surface 101b side of the base material, or may be formed so as to have fine dot-like structures spread all over.

Like the package 1 of the first embodiment described above, the package 51 of the present embodiment is less likely to stick before it is attached to the PTP sheet, thereby reducing the complexity of handling.
The pressure-sensitive adhesive layer 102A of the present embodiment is more likely to stick than the rubber latex-based pressure-sensitive adhesive layer 102, but in the sheet-like material 100A of the present embodiment, the second surface 101b side surface of the base material 101 is Since the release layer 103 is formed, the release force when the pressure-sensitive adhesive layers 101 are opposed to each other and bonded is the second highest between the pressure-sensitive adhesive layer 102 and the base material 101 regardless of the pressure-sensitive adhesive. A relationship is realized that is four times or more the peeling force when the surface 101b side is brought into contact and pressed with a predetermined force.

In this embodiment, the information part does not have to be directly formed on the substrate. For example, the information section may be formed by laminating a printed film on the second surface side of the substrate.

The present invention will be described using examples.
(Example 1)
A high-quality paper (Jet Ace W manufactured by Nippon Paper Industries Co., Ltd.) having a thickness of 370 μm and a thickness of about 310 g/m ² was prepared as a base material. A printed portion having a thickness of about 1.5 μm was formed on the second surface side of the substrate by offset printing using offset UV ink (manufactured by T&K TOKA).
Next, a pressure-sensitive adhesive layer was formed on the first surface side of the substrate by gravure coating using a rubber latex-based pressure-sensitive adhesive (FB Flutite 1007 manufactured by Kuo Yu Kasei Co., Ltd.). The coating amount of the pressure-sensitive adhesive was 17.0 g/m ² .
As described above, the sheet-like material of Example 1 was formed.
The sheet material was cut into rectangles of 180 mm long and 150 mm wide, and 10 circular openings were formed in each of the first and second regions. The diameter of the opening was 8.4 mm in the first region and 10.0 mm in the second region.
The boundary line was a perforation (cut length 11.5 mm, uncut length 1.5 mm) extending in the longitudinal direction at a position of 75 mm in width (the center in the width direction).
As described above, the package of Example 1 was produced.

(Example 2)
The same procedure as in Example 1, except that after forming the printed part, a release layer having a thickness of about 1.5 μm was formed on the entire surface of the second surface of the substrate using a silicone-based release agent (manufactured by T&K TOKA). A sheet-like material and a package of Example 2 were produced according to the procedure.

A plurality of packages of each example were prepared, and the peel force was measured by the method described above.
As a result, in Example 1, the peel force when the pressure-sensitive adhesive layers were opposed to each other and bonded was 3.24 N/25 mm, and the load of 2000 g was applied when the pressure-sensitive adhesive layer was brought into contact with the second surface of the base material. The peel force after applying the pressure was 0.17 N/25 mm, and the ratio of the two was about 19:1.
In Example 2, the peel force when the pressure-sensitive adhesive layers were opposed to each other and bonded was 3.24 N/25 mm, the same as in Example 1, and a load of 2000 g was applied when the pressure-sensitive adhesive layer and the release layer were brought into contact. The peel force after application was unmeasurable (virtually zero).

As described above, in any of the examples, the peel force when the pressure-sensitive adhesive layers are opposed to each other and bonded is 4 times the peel force when the pressure-sensitive adhesive layer and the second surface side of the base material are brought into contact. It was shown to be more than double. In both examples, a rubber latex-based pressure sensitive adhesive was used to form the pressure sensitive adhesive layer; It was presumed that the relationship between the peeling forces described above could be sufficiently realized.

As a reference, sheet-like materials having the same structure as in Example 1 were prepared with different coating amounts of the pressure-sensitive adhesive, and the peel force when the pressure-sensitive adhesive layers were opposed to each other and joined was measured. Table 1 shows the results measured under the same conditions. From the results in Table 1, even if the coating amount is changed, the peel force does not change abruptly, and it is presumed that the relationship between the peel forces described above can be realized.

Although each embodiment of the present invention has been described above, the technical scope of the present invention is not limited to the above-described embodiments. Various changes can be made to or deleted from .

For example, in the present invention, the substrate may be partially or wholly transparent as long as the purpose of use is achieved. In the first embodiment, there is no problem even if the portion of the first region and the second region where there is no PTP sheet between them when attached to the PTP sheet is transparent. In the second embodiment, part or all of the substrate may be transparent in consideration of the visibility of the information in the information section.

Further, in the above description, an example in which paper is selected as the base material so that the package can be written on has been shown. A writing layer that allows writing with a ballpoint pen, oily pen, or the like may be formed on a part of the surface. The writing layer can be formed using, for example, a resin such as acrylic or cellulose, or a paint obtained by adding a filler such as a porous material or wax, or an additive to these resins. As a forming method, the same method as that for the printed portion can be used, and the thickness can also be in the same range as that for the printed portion.

Furthermore, the pressure-sensitive adhesive layer does not necessarily have to be provided over the entire surface of the first region and the second region. However, when the pressure-sensitive adhesive layers are formed in the first region and the second region so that the pressure-sensitive adhesive layers are opposed to each other in at least a part of the region where the PTP sheet is not present when the PTP sheet is sandwiched, the pressure-sensitive adhesive layer is large. PTP sheets can be wrapped with a peeling force, which is preferable.

INDUSTRIAL APPLICABILITY The present invention can be used for a PTP sheet card package.

Reference Signs List 1, 51 card package for PTP sheet 2, 52 opening 10 first region
20 second area 53 printing section (information section)
DESCRIPTION OF SYMBOLS 100, 100A Sheet-like material 101 Base material 102, 102A Pressure-sensitive adhesive layer 103 Release layer

Claims (6)

A PTP sheet package in which a PTP sheet is sandwiched between card packages for PTP sheets, comprising a first region having a plurality of openings and a second region having a plurality of openings and connected to the first region There is
the first region and the second region are formed of a sheet material;
The sheet-shaped material has a base material and a pressure-sensitive adhesive layer made of a pressure-sensitive adhesive and provided on one surface of the base material,
The pressure-sensitive adhesive layer is formed on both the first region and the second region,
The peeling force when the first region and the second region are joined with the pressure-sensitive adhesive layers facing each other is the upper PTP sheet card in the two stacked PTP sheet card packaging bodies. Four times the peel force when the pressure-sensitive adhesive layer of the package is bonded to the surface opposite to the surface on which the pressure-sensitive adhesive layer is provided on the base material of the PTP sheet card package on the lower side and
The PTP sheet card package has a display window at a position where neither the PTP sheet accommodating portion nor the back side of the accommodating portion is arranged,
A part of the PTP sheet is visible from the display window,
PTP sheet package . The region provided with the pressure-sensitive adhesive layer includes a region where the PTP sheet is not present between the first region and the second region,
The PTP sheet package according to claim 1. The PTP sheet has a code indicating that it is an investigational drug or a placebo, and the code is visible through the display window.
The PTP sheet package according to claim 1 or 2. The PTP sheet package according to any one of claims 1 to 3, having a perforation at the boundary between said first area and said second area. The PTP sheet packaging according to any one of claims 1 to 4, wherein the sheet-like material has an information part provided on the surface of the base material opposite to the surface on which the pressure-sensitive adhesive layer is provided. body . The PTP sheet packaging according to any one of claims 1 to 5, wherein the sheet material has a release layer provided on the surface of the substrate opposite to the surface provided with the pressure-sensitive adhesive layer. body .

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