JP6906788B2 - Hair growth composition - Google Patents

Description

The present invention relates to a hair growth composition.

Conventionally, a hair-growth composition containing a synthetic or natural extract having a blood circulation promoting effect on the skin has been used.

These extracts are not effective enough when blended in a small amount, and are too irritating to the skin when blended in a large amount. Therefore, a composition for skin containing carbon dioxide gas to enhance the blood circulation promoting action. Proposals have been made. Many of these generate carbon dioxide by the reaction of acidic substances and carbon dioxide generating substances. However, when these substances are used, there is a problem that it is difficult to mix an acidic substance and a carbon dioxide gas generating substance.

Therefore, it has been proposed to add a viscous substance to the acidic substance and the carbon dioxide generating substance at the time of mixing to make the mixing of the acidic substance and the carbon dioxide generating substance, particularly the carbonate, uniform. For example, in the skin care set of Patent Document 1, a carbonate is used as a first agent, an acidic substance is used as a second agent, a gel-like liquid agent containing a thickener and water is used as the first agent, and the second agent is thickened. It has been described that by using a liquid agent containing an agent and glycerin, blood circulation is promoted by uniformly mixing the two agents, and a growth promoting effect on the skin and hair is described.

Japanese Unexamined Patent Publication No. 2013-209331

However, according to the investigation by the present inventors, a viscous substance is added to each of an acidic substance and a carbonate such as the skin care set described in Patent Document 1, and a gelled two agents are applied to the skin. However, the blood circulation promoting effect as hair growth was not sufficient.

Therefore, it is an object of the present invention to provide a composition for hair growth that has a high blood circulation promoting effect and thereby enhances the hair growth effect by more specifying the dosage form.

As a result of diligent studies on various components that affect the dosage form that should be combined with acidic substances and carbonates in order to solve the above problems, the present inventors surprisingly found that acidic substances and carbonates. It was found that when a specific component that affects the dosage form was combined with carbonate, it showed a large blood circulation promoting effect. Moreover, it was surprising that the degree of action was significantly greater than that of the skin care set of Patent Document 1.

As a result, the present inventors have succeeded in creating a hair-growth composition in which a specific component to be mixed with an acidic substance and a carbonate is combined as a hair-growth composition. The present invention is an invention completed based on such findings and successful examples.

Therefore, according to the present invention, the hair growth compositions according to the following [1] to [3] are provided.
[1] A hair-growth composition comprising a liquid composition containing an acidic substance, a moisturizer and water, and a powdery or gel-like composition containing a carbonate and a thickener.
A hair-growth composition that is configured to be applied to the skin by mixing a liquid composition with a powdery or gel-like composition when the hair-growth composition is used.
[2] A hair-growth composition comprising a liquid composition containing a carbonate, a moisturizer and water, and a powdery or gel-like composition containing an acidic substance and a thickener. A hair-growth composition that is configured to be applied to the skin by mixing a liquid composition with a powdery or gel-like composition at the time of use.
[3] A hair-growth composition comprising a liquid composition containing a moisturizer and water and a powdery composition containing a carbonate, an acidic substance and a thickener, and when the hair-growth composition is used. , A hair-growth composition configured to be a mixture of a liquid composition and a powdery composition and applied to the skin.

The composition for hair growth according to one aspect of the present invention can exhibit a remarkably high blood circulation promoting effect by specifying the optimum dosage form for the active ingredient. The hair-growth composition according to one aspect of the present invention is added to the main component due to the difference in the dosage form, even if the finally applied component is the same as that of the conventional hair-growth composition. Since the characteristics of the main components can be maximized by different combinations of the components to be produced, it can be easily manufactured with existing equipment, and its safety is also guaranteed. The composition for hair growth according to one aspect of the present invention has such a blood circulation promoting action, thereby promoting blood circulation, and in particular, a hair growth promoting effect for growing hair can be expected.

FIG. 1 is a diagram in which each test substance and a control solution were applied to the back of each mouse, and the back of each mouse was photographed 35 days after the test, as described in Examples described later. FIG. 2 is a diagram in which the hair growth state of mice on the 28th and 35th days after application of each test substance was evaluated based on the evaluation criteria, as described in Examples described later.

Hereinafter, the details of the hair-growth composition, which is one aspect of the present invention, will be described, but the technical scope of the present invention is not limited to the matters of this item, and the present invention is as long as the object is achieved. Can take various aspects in.

The hair-growth composition according to one aspect of the present invention contains at least an acidic substance, a carbonate, a moisturizer, water and a thickener, and by mixing these at the time of use, carbon dioxide gas (carbon dioxide) is generated and the skin is generated. It is to be applied to. Further, the hair-growth composition is composed of at least two forms of a liquid composition and a powdery or gel-like composition, and the liquid composition contains at least a moisturizing agent and water, and is powdery or powdery. The gel composition contains at least a thickener. Therefore, it can take any of the following forms (1) to (3).

(1) A liquid composition containing an acidic substance, a moisturizing agent and water, and a powdery or gel-like composition containing a carbonate and a thickener are provided, and when used, the liquid composition and the powdery composition are provided. Alternatively, a hair-growth composition that is mixed with a gel-like composition and applied to the skin to generate carbon dioxide gas.
(2) A liquid composition containing a carbonate, a moisturizer and water, and a powdery or gel-like composition containing an acidic substance and a thickener are provided, and when used, the liquid composition and the powdery composition are provided. Alternatively, a hair-growth composition that is mixed with a gel-like composition and applied to the skin to generate carbon dioxide gas.
(3) A liquid composition containing a moisturizing agent and water, and a powdered composition containing a carbonate, an acidic substance and a thickener are provided, and the liquid composition and the powdered composition are used when used. A hair-growth composition that is applied to the skin to generate carbon dioxide gas.

The hair-growth composition according to one aspect of the present invention is in powder form with a combination of a moisturizer and water that form a liquid form as an additional component that characterizes the form to be combined with respect to the main components of the acidic substance and carbonate. Alternatively, the thickener that forms a gel-like form is separated and combined with the main components of each. Hereinafter, each constituent component contained in the composition of one aspect of the present invention and a method for producing the same will be described.

<Acid substances>
The acidic substance used in the present invention may be either an organic acid or an inorganic acid, and one or more of these may be used. Further, these may be solid, gaseous or liquid, and are not particularly limited as long as they are acids that can react with carbonates to generate carbon dioxide and can be used on the skin.

Inorganic acids include phosphoric acid, potassium dihydrogen phosphate, sodium dihydrogen phosphate, sodium sulfite, potassium sulfite, sodium pyrosulfite, potassium pyrosulfite, sodium acidic hexamethaphosphate, potassium hexametaphosphate, acidic sodium pyrophosphate, Examples include acidic potassium pyrophosphate and sulfamic acid.

Organic acids include linear fatty acids such as formic acid, acetic acid, propionic acid, butyric acid and valeric acid, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelli acid, fumaric acid, maleic acid, phthalic acid and isophthalic acid. Dicarboxylic acids such as acids and terephthalic acids, acidic amino acids such as glutamate and aspartic acid, glycolic acid, malic acid, tartaric acid, citric acid, lactic acid, hydroxyacrylic acid, α-oxybutyric acid, glyceric acid, tartronic acid, salicylic acid, gallic acid. , Oxy acids such as tropic acid, ascorbic acid and gluconic acid. Of these, citric acid, ascorbic acid, malic acid, and succinic acid are preferable from the viewpoint of skin safety and solubility.

The amount of the acidic substance to be blended can be either a liquid composition or a powdery or gel-like composition. When blended in the liquid composition, 0.01 to 30% by mass is preferable, 0.05 to 25% by mass is more preferable, and 0.5 to 20% by mass is particularly preferable in the liquid composition. When blended in the powdery composition, 0.01 to 40% by mass is preferable, 0.05 to 35% by mass is more preferable, and 0.5 to 30% by mass is particularly preferable in the powdery composition. When blended in the gel-like composition, 0.01 to 30% by mass is preferable, 0.05 to 25% by mass is more preferable, and 0.5 to 20% by mass is particularly preferable in the gel-like composition. The acidic substance is preferably 0.001 to 25% by mass, more preferably 0.01 to 20% by mass in the hair growth composition. The above range is advantageous in that a composition having both foaming power and foaming durability can be obtained. Further, when the acidic substance is added to the gel-like composition, the viscosity of the gel during storage may be lowered. Therefore, it is preferable to add the acidic substance to the liquid composition or the powdery composition.

<Carbonate>
The carbonate used in the present invention can be used without particular limitation as long as it can react with the acid used in the present invention to generate carbon dioxide. The carbonates are preferably carbonates such as sodium carbonate, calcium carbonate, potassium carbonate, magnesium carbonate, sodium sesquicarbonate, ammonium hydrogencarbonate, potassium hydrogencarbonate, sodium hydrogencarbonate, lithium hydrogencarbonate, cesium hydrogencarbonate, hydrogen carbonate. Examples thereof include hydrogen carbonates such as magnesium and calcium hydrogen carbonate, and one or more of these may be used. Among these, sodium hydrogen carbonate is more preferable in that hydrogen carbonate can be preferably used and an appropriate foaming power can be realized. Further, these may be solid or liquid, and are not particularly limited, but are solid in that the reaction of carbon dioxide gas is likely to occur quickly and the generation of carbon dioxide gas is easily controlled by adjusting the amount. It is preferable to use one.

The blending amount of the carbonate can be blended in the liquid composition or the powdery or gelling composition. When blended in the liquid composition, 0.01 to 30% by mass is preferable, 0.1 to 25% by mass is more preferable, and 1 to 20% by mass is particularly preferable in the liquid composition. When blended in the powdery composition, 0.01 to 40% by mass is preferable, 0.1 to 35% by mass is more preferable, and 1 to 30% by mass is particularly preferable in the powdery composition. When blended in the gel-like composition, 0.01 to 30% by mass is preferable, 0.1 to 25% by mass is more preferable, and 1 to 20% by mass is particularly preferable in the gel-like composition. Further, 0.01 to 25% by mass is preferable, and 0.1 to 20% by mass is more preferable in the hair growth composition. The above range is advantageous in that a composition having both foaming power and foaming durability can be obtained.

<Moisturizer>
The moisturizing agent used in the present invention is not particularly limited as long as it can be usually used in cosmetics, external medicines, non-pharmaceutical products, etc., and polyhydric alcohols having two or more hydroxy groups in one molecule, such as glycerin, Polyglycerin such as diglycerin, triglycerin, tetraglycerin, ethylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3-propanediol, erythritol, mulch Examples thereof include sugar alcohols such as toll, mannitol, sorbitol and xylitol, polyglycerin derivatives, sugars such as sucrose and trehalose. Also, polyoxyalkylene alkyl glucoside, sodium lactate, sodium pyrrolidone carboxylate, almond, avocado, artea, aloe, cheeses, ononis, crow wheat, quince seed, clara (kujin), quince, grapefruit, creson, geranium, geranium thunbergii, gobo, Wheat, cycin, cactus, cactus, cactus, quince, geranium, geranium, quince, geranium thunbergii, quince, quince, quince, quince, quince, quince, quince, quince, quince, quince , Quince, Maronnier, Melissa, Yagurumasou, Yuri, Lime, Lavender, Apple, Rice and rice bran, Black currant, Ibukitranoo, Cheeses, Ezokogi, Seaweed, etc. Can be used. Among these, it is preferable to use at least one polyhydric alcohol or plant extract from the viewpoint of storage stability, manufacturing cost, and alleviation of irritation to the skin during use, and at least one polyhydric alcohol is used. It is more preferable, and it is particularly preferable to use two or more kinds. Among them, it is preferable to use at least one of glycerin, diglycerin, 1,3-butylene glycol, 1,4-butylene glycol, dipropylene glycol, and polyethylene glycol.

The blending amount of the moisturizer can be blended in the liquid composition and the powder or gel composition. It may be 1% by mass or more in the liquid composition, more preferably 3 to 90% by mass, and particularly preferably 5 to 80% by mass. When blended in the powder composition, it may be 1% by mass or more in the powder composition, more preferably 3 to 90% by mass, and particularly preferably 5 to 80% by mass. When blended in the gel-like composition, it may be 1% by mass or more in the gel-like composition, more preferably 3 to 90% by mass, and particularly preferably 5 to 80% by mass. Further, it may be 1% by mass or more in the hair growth composition, preferably 5 to 90% by mass, more preferably 8 to 80% by mass or more, and particularly preferably 10 to 70% by mass. Within the above range, the effects on the skin such as the amount of diffused water and elasticity are maintained high during use, and it is easy to handle during use. Further, the composition does not drip when applied to the skin, and carbon dioxide is sufficiently generated so that carbon dioxide gas is sufficiently supplied to the skin and the product value is maintained.

<Water>
As the water used in the present invention, water that can be used in cosmetics, external medicines, non-pharmaceutical products, etc. can be used, but purified water, distilled water, membrane-filtered water, ion-exchanged water, etc. are preferable.

The blending amount of the water can be blended in the liquid composition and the gel-like composition. When blended in the liquid composition, it may be blended in an amount of 1% by mass or more, preferably 5% by mass to 96% by mass, and more preferably 40 to 90% by mass. When blended in the gel-like composition, it may be blended in an amount of 1% by mass or more, preferably 5% by mass to 96% by mass, and more preferably 40 to 90% by mass. Further, it may be blended in an amount of 5% by mass or more in the entire hair growth composition, preferably 10 to 85% by mass, more preferably 20 to 80% by mass. Within the above range, the effects on the skin such as the amount of diffused water and elasticity are maintained high during use, and it is easy to handle during use. Further, the composition does not drip when applied to the skin, and carbon dioxide is sufficiently generated so that carbon dioxide gas is sufficiently supplied to the skin and the product value is maintained.

In the present invention, the mixing ratio (mass ratio) of the moisturizer: water contained in the liquid composition is not particularly limited, but is preferably 1: 0.05 to 30, and more preferably 1: 0.1 to 25. Yes, especially preferably 1: 0.5 to 20. Within the above range, high production efficiency is maintained without taking time to dissolve carbonates, acidic substances, and thickeners in the liquid composition, powder or gel composition, and the liquid composition and powder. The rate of carbon dioxide generation due to the reaction with the liquid or gel composition is maintained. In addition, the viscosity of the moisturizer itself does not decrease significantly, and the viscosity of the entire composition after mixing the liquid or gel composition with the powder or gel composition does not decrease, and the product can be sufficiently used as a product. It will be easy to do.

<Thickener>
The thickener used in the present invention is not particularly limited as long as it is a water-soluble component that can be used in cosmetics, external medicines, quasi-drugs, etc., and is a synthetic polymer, a semi-synthetic polymer, a natural polymer, and a viscosity. Minerals can be used.

Synthetic polymers include carboxyvinyl polymer, polyvinyl alcohol, acrylic acid / alkyl methacrylate copolymer, acrylic acid / alkyl acrylate crosspolymer, polyacrylic acid, polyacrylamide, polyalkylacrylamide / polyacrylamide copolymer, carboxymethyl cellulose, cation. Examples thereof include hydrophilic synthetic polymers such as acrylamide and Pluronic.

Examples of the semi-synthetic polymer include carboxymethyl cellulose and salts thereof, methyl cellulose, ethyl cellulose, propyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, and sulfonated cellulose derivatives. Other semi-synthetic polymers include propylene glycol alginate, ethylene glycol alginate, dextrin fatty acid ester, gelatin fatty acid ester, gelatin fatty acid amide and the like.

Natural polymers include polysaccharides and derivatives thereof, such as xanthan gum, tamarind gum, succinoglycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragant gum, agar, agarose, mannan, curdlan, etc. Examples thereof include alginic acid and salts thereof, gum arabic, pectin, quinceed, starch derivative, algae colloid, chondroitin sulfate and salts thereof, chitosan and derivatives thereof. Other natural polymers include nucleic acids and salts thereof, ribonucleic acid and salts thereof, casein, collagen, gelatin, albumin, fibroin, elastin, keratin, sericin and other water-soluble proteins, hyaluronic acid and its salts, chondroitin sulfate and the like. Examples include mucopolysaccharide.

Examples of clay minerals include laponite, bentonite, smectite kaolinite, and montmorillonite.

Among these, as thickeners with high solubility and dispersibility, carboxyvinyl polymer, carboxymethyl cellulose and salts thereof, polyvinyl alcohol, sodium polyacrylate, alginic acid / alkyl methacrylate copolymer, xanthan gum, tamarind gum, succino Glycan, carrageenan, guar gum, locust bean gum, celluloses, galactan, arabic gum, tragant gum, agar, mannan, curdran, alginic acid and its salts, collagen, gelatin, albumin, etc., in particular, tamarind gum, alginic acid and its salts. It is preferable to use salts, hydroxyethyl cellulose, carboxymethyl cellulose and salts thereof, xanthan gum, carrageenan, and albumin. In particular, tamarind gum, xanthan gum, carrageenan, sodium alginate, hydroxyethyl cellulose or sodium carboxymethyl cellulose is preferable.

The thickener is blended only in powdered or gelled compositions. When blended in the powdery composition, 0.01 to 50% by mass is preferable, 0.05 to 40% by mass is more preferable, and 0.1 to 35% by mass is particularly preferable in the powdery composition. When blended in the gel-like composition, 0.01 to 30% by mass is preferable, 0.05 to 25% by mass is more preferable, and 0.1 to 20% by mass is particularly preferable in the gel-like composition. Further, 0.001 to 30% by mass is preferable, 0.005 to 25% by mass is more preferable, and 0.1 to 20% by mass is particularly preferable in the hair growth composition. Within the above range, the viscosity of the powdery or gel-like composition is maintained, and the product value is maintained without dripping when the hair-growth composition mixed with the liquid composition is applied to the skin. .. Further, since the viscosity of the powdery or gel-like composition is maintained, the hair-growth composition can be easily prepared, and can be easily mixed with the acidic substance in the hair-growth composition, so that it can be used as a product. Becomes easier.

<Other ingredients>
In addition to the acidic substances, carbonates, moisturizers, waters and thickeners, the hair-growth composition of the present invention can be appropriately selected according to the purpose thereof, and includes excipients, pH adjusters, fats and oils. Fragrances, colorants, antioxidants, hygroscopic agents, preservatives, antibacterial and antifungal agents, alcohols, nonionic surfactants, anionic surfactants, cationic surfactants, amphoteric surfactants and other surfactants, anti-surfactants One or more of the active ingredients such as oxidizing agents, inorganic salts, lubricants, solvents, and other ingredients usually used in cosmetics, external medicines, non-pharmaceutical products, etc. can be used. In this case, the component to be added can be contained in the liquid composition, the powdery or gelled composition, or both.

Examples of the surfactant used in the present invention include nonionic surfactants, anionic surfactants, cationic surfactants, and amphoteric surfactants. As the surfactant, either a synthetic surfactant or a natural surfactant can be used, but from the viewpoint of skin safety, the natural surfactant is preferable. The term "natural surfactant" as used herein refers to a substance having a surface-active effect mainly derived from animals or plants, and specific examples thereof include phospholipids such as lecithin, glycolipids, lanolin, cholesterol, saponin, and ceramide. Examples thereof include sphingolipids such as, pectin, glycyrrhizinate, bile acids, and plant-extracted amino acid-based surfactants. Among them, it is preferable to contain an extract containing phospholipid, saponin, sphingolipid, pectin, and glycyrrhizate, and it is particularly preferable to contain an extract containing saponin. As the extract containing saponin, it is preferable to use a plant-derived extract. Examples of plants containing saponin include soybeans, azuki beans, green beans, spinach, sugar cane, grapes, kikyo, licorice, senega, kiraya, mukuroji, saponin, ginseng, hechima, tea seeds, enju, liliaceae. , Ginseng plants, Chimo (common bean), Bakumondou (wheat gate winter), etc. In the present invention, as the extract containing saponin, it is preferable to contain an extract of one or more plants selected from soybean, adzuki bean, licorice, mukuroji, and loofah among these plants, and in particular, licorice and mukuroji. It preferably contains an extract. When this natural surfactant is used in combination with a thickener, the viscosity can be maintained high and the bubbles of carbon dioxide gas can be kept longer. When such a surfactant is contained, the content thereof is preferably 0.0001% by mass or more, and 0.001% by mass or more and 10% by mass or less in the hair growth composition of the present invention. Is more preferable.

In the present invention, excipients can be used in the powdery composition. As the excipient used in the present invention, for example, powders such as lactose, powdered sugar, xylitol, D-sorbitol, glucose (glucose), D-mannitol, fructose, sucrose, sucrose, and urea are not particularly limited. , Alone, or in combination of two or more. When such an excipient is contained, the content thereof is preferably 1% by mass or more, more preferably 5% by mass or more and 90% by mass or less in the hair growth composition of the present invention.

Examples of the preservative used in the present invention include benzoic acid or a salt thereof, paraoxybenzoic acid ester, phenoxyethanol, sodium dehydroacetate, hinokitiol and the like. In the present invention, it is preferable to add a preservative to the liquid composition or the gel-like composition from the viewpoint of storage stability. When such a preservative is contained, the content thereof is preferably 0.001% by mass or more, and preferably 0.01% by mass or more and 30% by mass or less in the hair growth composition of the present invention. More preferred.

Examples of the hygroscopic agent used in the present invention include starch, dextrin, Ca stearate and the like. In the present invention, it is preferable to add a hygroscopic agent to the powdered composition from the viewpoint of preventing the acid from reacting with the carbonate. When such a hygroscopic agent is contained, the content thereof is preferably 0.05% by mass or more, preferably 0.1% by mass or more and 90% by mass or less in the hair growth composition of the present invention. More preferred.

Examples of the active ingredient such as the antioxidant used in the present invention include plant extracts such as lycopene, polyphenols, chimpi extract, and cha extract. In the present invention, it can be blended from the viewpoint of preventing oxidation and deterioration. When the active ingredient of such an antioxidant is contained, the content thereof is preferably 0.0001% by mass or more, preferably 0.001% by mass or more and 30% by mass or less in the hair growth composition of the present invention. Is more preferable.

The hair-growth composition according to one aspect of the present invention contains 0.05 to 25% by mass of an acidic substance, 3 to 90% by mass of a moisturizer, and 5 by mass of water so that the total amount of the liquid composition is 100% by mass. 0.1 to 35% by mass of carbonate and 0 of thickener so that the total amount of the liquid composition containing ~ 96% by mass and other components and the powdered composition is 100% by mass. A hair-growth composition comprising a powdery composition containing 05 to 40% by mass and the remaining amount of other components. When the hair-growth composition is used, the liquid composition and the powdery composition are mixed. A hair-growth composition that is configured to be mixed and applied to the skin.

The hair-growth composition according to one aspect of the present invention contains 0.05 to 25% by mass of an acidic substance, 3 to 90% by mass of a moisturizer, and 5 by mass of water so that the total amount of the liquid composition is 100% by mass. 0.1 to 25% by mass of carbonate and 0 of thickener so that the total amount of the liquid composition containing ~ 96% by mass and other components and the gel-like composition is 100% by mass. A hair-growth composition comprising a gel-like composition containing 05 to 25% by mass and the remaining amount of other components, and when the hair-growth composition is used, the liquid composition and the gel-like composition are mixed. A hair-growth composition that is configured to be mixed and applied to the skin.

The hair-growth composition according to one aspect of the present invention contains 0.1 to 25% by mass of carbonate, 3 to 90% by mass of moisturizer, and 5 by mass of water so that the total amount of the liquid composition is 100% by mass. 0.05 to 35% by mass of acidic substances and 0 thickener so that the total amount of the liquid composition containing ~ 96% by mass and other components and the powdered composition is 100% by mass. A hair-growth composition comprising a powdery composition containing 05 to 40% by mass and the remaining amount of other components. When the hair-growth composition is used, the liquid composition and the powdery composition are mixed. A hair-growth composition that is configured to be mixed and applied to the skin.

The hair-growth composition according to one aspect of the present invention contains 0.1 to 25% by mass of carbonate, 3 to 90% by mass of moisturizer, and 5 by mass of water so that the total amount of the liquid composition is 100% by mass. 0.05 to 25% by mass of acidic substances and 0 thickener so that the total amount of the liquid composition containing ~ 96% by mass and other components and the gel-like composition is 100% by mass. A hair-growth composition comprising a gel-like composition containing 05 to 25% by mass and the remaining amount of other components, and when the hair-growth composition is used, the liquid composition and the gel-like composition are mixed. A hair-growth composition that is configured to be mixed and applied to the skin.

The hair-growth composition according to one aspect of the present invention contains 3 to 90% by mass of a moisturizer, 5 to 96% by mass of water, and the remaining amount of other components so that the total amount of the liquid composition is 100% by mass. 0.1 to 35% by mass of carbonate, 0.05 to 35% by mass of acidic substances, and 0 thickener so that the total amount of the liquid composition and the powdery composition contained is 100% by mass. A hair-growth composition comprising a powdery composition containing 05 to 40% by mass and the remaining amount of other components. When the hair-growth composition is used, the liquid composition and the powdery composition are mixed. A hair-growth composition that is configured to be mixed and applied to the skin.

<Usage pattern>
The hair-growth composition according to one aspect of the present invention can be mixed in any of the following forms when used.
(1) Carbon dioxide gas is generated by mixing a liquid composition containing an acidic substance, a moisturizer and water with a powdery or gel-like composition containing a carbonate and a thickener.
(2) Carbon dioxide gas is generated by mixing a liquid composition containing a carbonate, a moisturizer and water with a powdery or gel-like composition containing an acidic substance and a thickener.
(3) Carbon dioxide gas is generated by mixing a liquid composition containing a moisturizer and water with a powdery composition containing a carbonate, an acidic substance and a thickener.

In any of the above forms, the liquid composition and the powdery or gel-like composition (liquid composition: powdery or gel-like composition) are preferably mixed at a ratio of 0.1 to 30: 1. , 0.5-10: 1 is more preferred.

When the hair-growth composition of the present invention is stored in a container, a method for storing cosmetics, external medicines, quasi-drugs, etc. can be used, and there is no particular limitation. The shape of the storage container to be used can be appropriately selected depending on the intended purpose, and examples thereof include a cup shape, a tube shape, a bag shape, a bottle shape, a stick shape, a pump shape, a jar shape, and a canned shape. Further, as the material constituting the storage container, for example, plastic, glass, aluminum, paper, various polymers and the like can be used alone or by selecting two or more kinds, but the material is not limited thereto.

Specific examples of containers include aluminum sticks whose inner surface is laminated with polyethylene terephthalate, storage containers such as aluminum bags, stand pouches with chucks, and polyethylene terephthalate on the inner surface in terms of airtightness, storage stability of contents, manufacturing cost, etc. A storage container made of polyethylene terephthalate whose lid is heat-sealed with an aluminum film or the like laminated with the above is preferable.

In addition, the hair-growth composition according to one aspect of the present invention can be used by preparation. The ratio of the acidic substance to the carbonate that reacts with the acidic substance to generate carbon dioxide in the hair-growth composition obtained by mixing the liquid composition in the above three forms with the powdery or gel-like composition is different. It depends on whether it is mixed in the liquid composition or the powdery or gel-like composition, and it depends on the type of acidic substance contained, the solvent, the viscous substance and the setting of pH. Set as appropriate. Preferably, the composition is blended so that carbonic acid gas is generated to the maximum and the amount of unreacted substances is as small as possible.

When the liquid composition of the hair-growth composition of one aspect of the present invention is mixed with the powdery or gel-like composition, as a method of mixing the liquid composition, for example, using a spatula, a spatula, a palm or the like, glass or plastic. A known method such as a method of mixing in a container such as, a method of mixing on the skin such as a palm, etc. can be used.

As a method of mixing the liquid composition and the powdery or gel-like composition and applying the composition to the skin, the two compositions can be mixed so as to be applied to the skin at the same time. It is also possible to mix each liquid, powder or gel composition so that it is applied to the skin at different times. Specifically, the liquid composition and the powdery or gel-like composition can be completely mixed and then applied to the skin. Alternatively, after the liquid composition is partially mixed with the powdery or gelled composition, the remaining amount of each composition can be applied to the skin. Alternatively, either the liquid composition or the powdered or gelled composition can be applied to the skin and then the other composition can be applied.

The coating amount of hair growth composition is not particularly limited, but may appropriately be set in accordance with the extent or coating aspect of hair growth amount required for the coating's example, as a coating amount single dose, area 2 cm ² × skin Based on 4 cm ² , the total amount of the auxiliary components of the acidic substance, carbonate, moisturizer, water and thickener is 10 mg / 8 cm ² or more, preferably 100 mg / 8 cm ² or more.

<Use of the present invention>
The hair-growth composition according to one aspect of the present invention has been found to significantly promote hair growth in particular when the dosage form of the composition containing an acidic substance and a carbonate is specified, leading to the present invention. In particular, the combination of a liquid composition containing a moisturizer and water and a powdery or gel-like composition containing a thickener exhibits the maximum hair growth promoting effect as shown in the following examples. It can be suitably used as a hair growth promoter. As a result, the dosage form of the conventional effervescent skin external preparation is not particularly limited, and the dosage form can be optimized for the hair growth effect that was insufficient for the product with improved skin improvement. By specifying to take, a remarkably excellent hair restorer is provided with respect to the existing safety-confirmed ingredients in the conventional hair restorer. Due to such a hair growth promoting action, its use is useful for consumers who are not satisfied with the hair restorer with conventional products, and middle-aged and elderly men and women who desire the effect of hair growth especially in an aging society. It is also highly safety-conscious and useful for young people in a high-stress society.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples, and the present invention can take various aspects as long as the problems of the present invention can be solved. ..

As follows, the hair growth promoting effect of the combination of the acidic substance, the carbonate and the sub-ingredient was evaluated.

(1) Test substance <Comparative Example 1>
Each component shown in Table 1 was blended and mixed in the composition shown in the same table, and a gel-like composition (agent A) and a gel-like composition (agent B) were prepared by adding the remaining amount of purified water. These were mixed so that Agent A and Agent B had a mass ratio of 1: 1 to prepare about 200 mg of the test substance. The numerical values in Table 1 below are the mass ratios (mass%) in the hair growth compositions A and B.

<Example 1 and Example 2>
A powdery composition (agent A) prepared by blending and mixing each component shown in Table 2 with the composition shown in the same table and a liquid composition (agent B) prepared by adding the remaining amount of purified water were prepared. These were mixed so that the mass ratio of the agent A and the agent B was 1: 3, and about 200 mg of the test substance was prepared. The numerical values in Table 2 below are the mass ratios (mass%) in the hair growth compositions A and B.

<Example 3>
Each component shown in Table 3 was blended and mixed in the composition shown in the same table, and a gel-like composition (agent A) and a liquid composition (agent B) were prepared by adding the remaining amount of purified water. These were mixed so that Agent A and Agent B had a mass ratio of 2: 1 to prepare about 200 mg of the test substance. The numerical values in Table 3 below are the mass ratios (mass%) in the hair growth compositions A and B.

(2) Experimental animals Male mice (SPF, C3H / HeN system) produced by Nippon SLC Co., Ltd. were used.

(3) Animal breeding management method The mouse breeding management method was as follows.
Habituation period : 7 days Lighting time: 12 hours (8:00 to 20:00) / day Cage: Polycarbonate flat bottom cage (W182 x L260 x H128 mm, Japan Claire Co., Ltd.)
Flooring: Wood chips (soft chips, Japan SLC Co., Ltd.)
Containment: 2-3 animals were housed in one cage.
Test period Breeding period: 36 days Lighting time: 12 hours (8:00 to 20:00) / day Cage: Polycarbonate flat bottom cage (W182 x L260 x H128 mm, Japan Claire Co., Ltd.)
Flooring: Wood chips (soft chips, Japan SLC Co., Ltd.)
Containment: 2-3 animals were housed in one cage.

The groups of animals bred as described above were as follows. On the 0th day of the test (the day after the back hair removal) after the end of the acclimation period, animals with healthy back skin were divided into groups so that the body weight values were almost uniform, and the animals were subjected to the test.

The individual identification method used an oil-based marker to draw a line on the tail. A red oil-based marker was used during the acclimation period, and a black oil-based marker was used during the test period.

Mice were allowed to freely ingest MF solid feed, and tap water confirmed to be appropriate was used as drinking water from regular water quality inspection data by the Saga Prefectural Environmental Science Inspection Association.

(4) Test method A 7-week-old male mouse (C3H / HeN) was acclimatized for 6 days, and then the back was removed under somnopentyl anesthesia (test-day 1). On the 0th day of the test (the day after hair removal on the back), those with healthy back skin were grouped based on their body weight values. Two or three mice were housed in one cage. The test substances (Tables 1 to 3) of Comparative Examples 1 and 1 to 3 corresponding to each group were applied every day from the 0th day of the test to the end of the test, except for designated holidays (however, until the 28th day of the test). One spatula (about 200 mg) of the test substance was applied to the hair-removed back skin (every day including holidays). As a control, 200 mg of purified water was applied. These coating methods are shown in Table 4 below.

(Test substance and application method)

(5) Evaluation test On days 0, 28 and 35, the back of each mouse was photographed and the hair growth state was evaluated by the score. A photograph of the back of the mouse 35 days after applying each test substance is shown in FIG. The hair growth score was performed by three people in order to have objectivity, and the average value was used as the measured value.

Table 5 shows the evaluation criteria for the hair growth state of each test substance.

(Hair growth score evaluation criteria)

FIG. 2 shows the results of evaluation of the hair growth state of the mice on the 28th and 35th days after applying each test substance based on the above evaluation criteria. The numerical values of the hair growth score in FIG. 2 are shown in Table 6 below.

As shown in FIG. 2, on the 28th day from the start of the test, the gel-like composition containing the thickener and the gel-like composition containing the thickener were mixed as compared with the control to which pure water was applied. In Comparative Example 1, which is the composition obtained, the hair growth state was rather inhibited. On the other hand, on the 28th day, a composition obtained by mixing a powdery or gel-like composition containing a thickener and a liquid composition containing a moisturizer and water according to Examples 1 to 3 of the present invention was applied. In some cases, there was a significant hair growth promoting effect as compared with the control and Comparative Example 1. In particular, in the case where the powdery composition containing the thickener and the liquid composition containing the moisturizer and water of Example 1 are mixed and then applied to the skin at the same time, the powdery composition containing the thickener is used. The amount of the liquid composition containing the moisturizer and water to be mixed was divided in half with respect to the total amount of the substance, half of the amount was mixed and applied, and then only the other half of the liquid composition was applied. Example 2 was more effective than Example 1. Further, Example 3 in which the entire amount of the gel-like composition containing the thickener was applied to the skin and then the entire amount of the liquid composition containing water was applied to the skin at the time of moisturizing was more remarkable than in Examples 1 and 2. The effect was high. In Example 3, there was a remarkable promoting effect three times as much as that of the control containing only purified water and Comparative Example 1.

In addition, on the 35th day from the start of the test, the hair growth effect became higher in the order of control <Comparative Example 1 <Example 1 <Example 2 <Example 3. In particular, the hair growth result of Example 3 was very surprisingly effective in promoting hair growth about 5 times as much as that of the control, and 2.5 times as much as that of Comparative Example 1.

From the above results, a gel-like composition containing a thickener, a moisturizer and water for a conventional acidic substance and a gel-like composition containing a thickener, a moisturizer and water for a carbonate are simply used. A moisturizer and water by mixing and applying a powdery or gel-like composition containing a thickener and a liquid composition containing a moisturizer and water rather than the mixed composition. Since it is possible to prevent the viscosity characteristics of the thickener from being impaired by the influence of the above, the foaming state of carbon dioxide gas on the skin is improved, and as a result, blood circulation is promoted, so that the hair growth effect is remarkable. It turns out to be promoted.

Hereinafter, formulation examples of various aspects of the present invention will be given, but the technical scope of the present invention is not limited to these formulation examples.

(Prescription Example 1) Hair restorer A hair restorer was prepared by the same method as in Examples 1 and 2 according to the formulations shown in Table 7 below. It can be produced by blending a powdery composition and a liquid composition at a ratio of 1: 5.

(Prescription Example 2) Hair restorer A hair restorer was prepared by the same method as in Examples 1 and 2 according to the formulations shown in Table 8 below. It can be produced by blending a powdery composition and a liquid composition at a ratio of 1:10.

(Prescription Example 3) Hair restorer A hair restorer was prepared by the same method as in Example 3 according to the formulations shown in Table 9 below. It can be produced by blending a gel-like composition and a liquid composition at a ratio of 1: 3.

(Prescription Example 4) Hair restorer A hair restorer was prepared by the same method as in Example 3 according to the formulations shown in Table 10 below. It can be produced by blending a gel-like composition and a liquid composition at a ratio of 1: 2.

The hair-growth composition according to one aspect of the present invention can specify the combination of components for generating carbon dioxide gas and generate optimum carbon dioxide gas generation on the skin. Therefore, the skin after application. As a result, the blood circulation of carbon dioxide can be promoted, and as a result, the effect of promoting hair growth can be enhanced, which is very useful for middle-aged and elderly people who have a desire to promote hair growth in an aging society and young people who have a high appearance and safety consciousness.

Claims (2)

Acidic substance, a hair growth composition comprising a liquid composition containing a humectant and water, and distearate E Le-like composition to contain carbonate and thickeners,
Wherein when using the hair growth composition, the liquid composition, hair growth composition characterized in that it is configured to a mixture of a di-E Le-like composition is applied to the skin. A hair-growth composition comprising a liquid composition containing a moisturizer and water and a powdery composition containing a carbonate, an acidic substance and a thickener.
A hair-growth composition characterized in that, when the hair-growth composition is used, the liquid composition and the powdery composition are mixed and applied to the skin.

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