JP6729149B2 - Syringe and prefilled syringe - Google Patents

Description

This invention relates to syringes and prefilled syringes.

Regarding conventional syringes, for example, Japanese Patent Laid-Open No. 2014-195516 discloses a syringe with a simple configuration for the purpose of accurately measuring liquids of various colors (Patent Document 1).

The syringe disclosed in Patent Document 1 includes a transparent or translucent outer cylinder and a plunger inserted into the outer cylinder. The outer cylinder is provided with a first scale for measuring the liquid in the outer cylinder, and the plunger is provided with a second scale for measuring the liquid in the outer cylinder. The second graduation is visible from a first direction orthogonal to the longitudinal direction of the plunger, is orthogonal to the longitudinal direction of the plunger, and is visible from a second direction different from the first direction. I can't.

Further, Japanese Patent Application Laid-Open No. 2015-29740 discloses a syringe for the purpose of easily visually recognizing the graduation portion in various applications including administration of a liquid medicine using a syringe pump (Patent Document 2). ).

In the syringe disclosed in Patent Document 2, a scale portion is provided on the syringe outer cylinder. The scale part has a first scale number and a second scale number provided at different positions in the circumferential direction of the syringe outer cylinder in different directions. The first scale number is provided vertically to the syringe outer cylinder, and the second scale number is provided horizontally to the syringe outer cylinder.

JP, 2014-195516, A JP, 2015-29740, A

As disclosed in the above-mentioned Patent Documents 1 and 2, a syringe used for administration of a drug solution to a patient is known. In such a syringe, generally, a barrel (outer cylinder) is provided with a scale portion for measuring the volume of the liquid medicine placed in the barrel.

On the other hand, in the manual of the drug solution, there are cases where the dose is displayed by volume (for example, mL) and the dose is displayed by weight (for example, mg). When the dose of the drug solution is indicated by the weight at the time of administration, it is necessary to convert the weight of the drug solution into the volume, which increases the burden on the medical site.

Therefore, an object of the present invention is to solve the above-mentioned problems, and to provide a syringe and a prefilled syringe which can easily cope with the conversion of measurement of different types of liquids.

A syringe according to one aspect of the present invention includes a barrel configured to allow a liquid to be placed therein, and a plunger inserted into the barrel. The barrel and the plunger are provided with a first scale portion for measuring the liquid and a second scale portion for measuring the liquid. The type of liquid measurement by the first scale and the type of liquid measurement by the second scale are different from each other. The first scale portion and the second scale portion include scale numbers. In the axial direction of the syringe, a position closer to the part that ejects liquid is called distal, and a position farther from the part that ejects liquid is called proximal. In this case, in the first graduation portion and the second graduation portion provided on the barrel and the plunger, the graduation numbers are added so as to increase from the distal side to the proximal side.
A syringe according to another aspect of the present invention includes a barrel configured to allow a liquid to be placed therein, and a plunger inserted into the barrel. At least one of the barrel and the plunger is provided with a first scale portion for measuring the liquid and a second scale portion for measuring the liquid. The type of liquid measurement by the first scale and the type of liquid measurement by the second scale are different from each other.

According to the syringe configured as described above, by using the first graduation portion or the second graduation portion, it is possible to realize a syringe that can easily handle conversion of different types of liquids.

Also preferably, the type of measurement by the first scale portion is the volume of liquid. The type of measurement by the second scale part is the weight of the liquid.

According to the syringe configured as described above, the volume of the liquid can be measured using the first scale portion and the weight of the liquid can be measured using the second scale portion.

Also preferably, the first scale portion and the second scale portion include scale numbers. In the axial direction of the syringe, a position closer to the part that ejects liquid is called distal, and a position farther from the part that ejects liquid is called proximal. In this case, in the first graduation portion and the second graduation portion provided on the barrel and the plunger, the graduation numbers are added so as to increase from the distal side to the proximal side.

According to the syringe configured as described above, when grasping the dose of the liquid, the first scale portion or the second scale portion provided on the plunger is used to grasp the remaining amount of the liquid after the administration of the liquid. In doing so, the first graduation portion or the second graduation portion provided on the barrel can be used.

Also preferably, the plunger includes a shaft portion having a cross-shaped cross section. The shaft portion has a first surface and a second surface which are arranged on both sides of the center of the cross shape and extend in the same plane. A first scale portion and a second scale portion are provided on the first surface and the second surface, respectively.

According to the syringe thus configured, the first graduation portion and the second graduation portion can be visually recognized when the plunger is viewed from one direction.

A prefilled syringe according to the present invention includes the syringe described in any of the above, and a liquid with which a barrel is filled. The first graduation portion and the second graduation portion are configured so as to correspond to the conversion of liquid measurement between the first graduation portion and the second graduation portion.

According to the prefilled syringe configured as described above, it is possible to realize a prefilled syringe that can easily handle conversion of different types of liquids.

As described above, according to the present invention, it is possible to provide a syringe and a prefilled syringe that can easily handle conversion of different types of liquids.

It is a perspective view showing a prefilled syringe in an embodiment of the invention. It is a side view which shows the barrel which comprises the prefilled syringe in FIG. It is a side view which shows the plunger which comprises the prefilled syringe in FIG. It is sectional drawing which shows the plunger seen from the arrow direction on the IV-IV line in FIG. It is a side view which shows an example of the usage type of the prefilled syringe in FIG. It is a perspective view which shows the modification of the prefilled syringe in FIG. It is a perspective view which shows the modification of the prefilled syringe in FIG. It is a perspective view which shows the modification of the prefilled syringe in FIG.

Embodiments of the present invention will be described with reference to the drawings. In the drawings referred to below, the same or corresponding members are designated by the same reference numerals.

FIG. 1 is a perspective view showing a prefilled syringe according to an embodiment of the present invention. FIG. 2 is a side view showing a barrel constituting the prefilled syringe in FIG. FIG. 3 is a side view showing a plunger constituting the prefilled syringe in FIG. 1.

In the present specification, a position closer to the site for ejecting the drug solution in the axial direction of the prefilled syringe (syringe) is called “distal”, and a position farther from the site for ejecting the drug solution is called “proximal”.

With reference to FIGS. 1 to 3, prefilled syringe 10 in the present embodiment is a syringe (syringe) preloaded with a drug solution. A typical example of the drug solution is an anticancer drug. The volume of the prefilled syringe 10 is 10 mL (50 mg).

The prefilled syringe 10 has a barrel 21, a plunger 31, and a drug solution 61. The barrel 21 is configured so that the chemical liquid 61 can be placed therein. The plunger 31 is inserted in the barrel 21.

More specifically, the barrel 21 has a main body portion 22, a flange portion 24, and a chemical liquid discharge portion 23 as its constituent parts.

The main body 22 has a cylindrical shape (preferably a cylindrical shape), and has a distal end and a proximal end at both ends thereof. The chemical liquid discharger 23 is provided at the distal end of the main body 22, and the flange 24 is provided at the proximal end of the main body 22.

The chemical liquid ejection part 23 is a part for ejecting the chemical liquid 61 with the use of the prefilled syringe 10. In the present embodiment, the chemical liquid ejection portion 23 is a male luer having a tapered outer peripheral surface conforming to ISO 594-1, the outer diameter of which becomes smaller toward the distal end. The shape of the chemical liquid ejection portion 23 is not limited to this, and may have any shape. An optional locking mechanism may be provided in order to prevent the female connector (eg, female luer, needle base, etc.) connected to the chemical liquid ejecting section 23 from being unintentionally separated. For example, a cylinder that surrounds the male luer that constitutes the chemical liquid discharger 23 may be provided, and an internal thread conforming to ISO 594-2 may be formed on the inner peripheral surface of the cylinder.

The flange portion 24 is a portion on which the user puts a finger when using the prefilled syringe 10. The flange portion 24 is provided so as to spread in a brim shape from the proximal end of the main body portion 22. In the present embodiment, the flange portion 24 has a substantially elliptical shape when viewed from the axial direction of the main body portion 22. The flange portion 24 has a pair of finger hook portions 24p and 24q that are spread out in the major axis direction of the substantially elliptical shape.

The main body portion 22, the flange portion 24, and the chemical liquid discharge portion 23 are integrally formed. The material of the barrel 21 is preferably substantially transparent in order to ensure the internal visibility. The material of the barrel 21 may not be transparent, such as metal, and in this case, it is preferable to provide a structure (for example, a window) that allows the inside of the barrel 21 to be visually recognized.

The material of the barrel 21 is not particularly limited, but for example, polypropylene, polyurethane, polyethylene, cyclic polyolefin, polyolefin such as polymethylpentene 1, polyester, nylon, polycarbonate, polymethylmethacrylate (PMMA), polyetherimide (PEI). , A resin material such as polyether sulfone, polyether ether ketone (PEEK), fluororesin, polyphenylene sulfide (PPS), polyacetal resin (POM), a metal material such as stainless steel, glass, or the like can be used.

The plunger 31 is inserted into the barrel 21 from the proximal end of the main body portion 22. By moving the plunger 31 from the proximal side to the distal side, the chemical liquid 61 in the barrel 21 is discharged from the chemical liquid discharger 23.

The plunger 31 has a shaft portion 32, a flange portion 33, and a gasket 36 as its constituent parts.

The shaft portion 32 has a rod shape (shaft shape), and has a distal end and a proximal end at both ends thereof. The gasket 36 is attached to the distal end of the shaft portion 32, and the flange portion 33 is provided at the proximal end of the shaft portion 32.

The gasket 36 is a portion that sends out the drug solution 61 in the barrel 21 as the plunger 31 moves from the proximal side to the distal side. The gasket 36 has a circular cross-sectional shape. The gasket 36 comes into close contact with the inner peripheral surface of the main body portion 22 when the plunger 31 is inserted into the barrel 21. A space surrounded by the barrel 21 and the gasket 36 forms a liquid chamber for the chemical liquid 61 in the barrel 21. The gasket 36 is provided slidably in the barrel 21 in the axial direction of the body portion 22.

The material of the gasket 36 is not particularly limited, but examples thereof include olefin elastomers, styrene elastomers, polyester elastomers, polyurethane elastomers, vulcanized rubbers such as silicone rubber, butyl rubber, and fluororubber, and those coated with fluororesin. Can be used.

The flange portion 33 is a portion that the user pushes with a finger when using the prefilled syringe 10. The flange portion 33 has a circular shape when viewed in the axial direction of the shaft portion 32.

The shaft portion 32 and the flange portion 33 are integrally formed. The material of the shaft portion 32 and the flange portion 33 can be selected from those exemplified as the material of the barrel 21 described above.

With reference to FIGS. 1 and 2, the barrel 21 is provided with a first scale portion 41 for measuring the chemical liquid 61 and a second scale portion 46 for measuring the chemical liquid 61. The type of measurement of the chemical liquid 61 by the first scale portion 41 and the type of measurement of the chemical liquid 61 by the second scale portion 46 are different from each other. In the present embodiment, the type of measurement by the first scale portion 41 is the volume of the chemical liquid 61, and the type of measurement by the second scale portion 46 is the weight of the chemical liquid 61.

The first scale portion 41 is composed of a scale 42, a scale number 43, and a scale unit 44.

The scales 42 are arranged at regular intervals along the axial direction of the main body 22. The scale number 43 indicates a number specified by the scale 42. In the present embodiment, the scale numbers 43 are attached so as to increase from the distal side toward the proximal side. As the scale number 43, integers from 0 to 10 are arranged from the distal side to the proximal side. The scale unit 44 is a unit of the volume of the chemical liquid 61 measured by the first scale portion 41, and is “mL” in the present embodiment.

The second graduation portion 46 is composed of a graduation 47, a graduation number 48, and a graduation unit 49.

The scales 47 are arranged at regular intervals along the axial direction of the main body portion 22. The scale number 48 indicates a number specified by the scale 47. In the present embodiment, the scale numbers 48 are attached so as to increase from the distal side toward the proximal side. As the scale number 48, 0, 10, 20, 30, 40, 50 are arranged from the distal side to the proximal side. The scale unit 49 is a unit of the weight of the chemical liquid 61 measured by the second scale unit 46, and is "mg" in the present embodiment.

The first graduation portion 41 and the second graduation portion 46 are configured to match the conversion of the measurement of the chemical liquid 61 between the first graduation portion 41 and the second graduation portion 46. In the present embodiment, the scale numbers 48 0, 10, 20, 30, 40, 50 (mg) in the second scale portion 46 are respectively 0, 2, 4, 4 of the scale number 43 in the first scale portion 41. Matches 6, 8, 10 (mL).

The first scale portion 41 and the second scale portion 46 are provided on the main body portion 22 of the barrel 21. The first graduation portion 41 and the second graduation portion 46 are provided adjacent to each other in the circumferential direction around the axis of the main body portion 22. The first graduation portion 41 and the second graduation portion 46 are provided within a phase range of 180° in the circumferential direction around the axis of the main body portion 22. The first graduation portion 41 and the second graduation portion 46 are provided centered on a phase position that is deviated by 90° from the pair of finger hooks 24p and 24q of the flange portion 24.

FIG. 4 is a cross-sectional view showing the plunger viewed from the direction of the arrow on the line IV-IV in FIG.

With reference to FIG. 1, FIG. 3 and FIG. 4, the plunger 31 has a first scale portion 51 for measuring the volume of the chemical liquid 61 corresponding to the first scale portion 41 provided on the barrel 21. A second scale portion 56 for measuring the weight of the liquid medicine 61 is provided corresponding to the second scale portion 46 provided on the barrel 21.

The first scale portion 51 is composed of a scale 52, a scale number 53, and a scale unit 54.

The scales 52 are arranged at regular intervals along the axial direction of the shaft portion 32. The scale number 53 indicates a number specified by the scale 52. In the present embodiment, the scale number 53 is attached so as to increase from the distal side toward the proximal side. As the scale number 53, integers from 0 to 10 are arranged from the distal side to the proximal side. The scale unit 54 is a unit of the volume of the chemical liquid 61 measured by the first scale portion 51, and is “mL” in the present embodiment.

The second scale portion 56 is composed of a scale 57, a scale number 58, and a scale unit 59.

The scales 57 are arranged at regular intervals along the axial direction of the shaft portion 32. The scale number 58 indicates a number specified by the scale 57. In the present embodiment, the scale numbers 58 are attached so as to increase from the distal side to the proximal side. As the scale number 58, 0, 10, 20, 30, 40, 50 are arranged from the distal side to the proximal side. The scale unit 59 is a unit of the weight of the chemical liquid 61 measured by the second scale unit 56, and is “mg” in the present embodiment.

The first graduation portion 51 and the second graduation portion 56 are configured to match the conversion of the measurement of the chemical liquid 61 between the first graduation portion 51 and the second graduation portion 56. In the present embodiment, the scale numbers 58 0, 10, 20, 30, 40, 50 (mg) in the second scale portion 56 are respectively 0, 2, 4, 4 of the scale number 53 in the first scale portion 51. Matches 6, 8, 10 (mL).

The first scale portion 51 and the second scale portion 56 are provided on the shaft portion 32 of the plunger 31. The shaft portion 32 has a cross-shaped (cross-shaped) cross section when cut by a plane orthogonal to the axial direction. The shaft portion 32 has a first surface 32a and a second surface 32b. The first surface 32a and the second surface 32b are arranged on both sides of the cross-shaped center 101 of the shaft portion 32. The first surface 32a and the second surface 32b extend in the same plane. The first scale portion 51 and the second scale portion 56 are provided on the first surface 32a and the second surface 32b, respectively.

The shaft portion 32 is not particularly limited as long as it has a surface on which the first graduation portion 51 and the second graduation portion 56 can be described. For example, the cross section of the shaft portion 32 has a circular shape or a square shape. It may be a polygonal shape such as.

FIG. 5: is a side view which shows an example of the usage type of the prefilled syringe in FIG. With reference to FIG. 5, the usage manual of the drug solution 61 may display the dose by volume or may display the dose by weight. In the present embodiment, the barrel 21 is provided with the first graduation portion 41 for measuring the volume of the chemical liquid 61 and the second graduation portion 46 for measuring the weight of the chemical liquid 61. Since the first graduation portion 51 for measuring the volume of the chemical liquid 61 and the second graduation portion 56 for measuring the weight of the chemical liquid 61 are provided, according to the dose type described in the usage manual. It is possible to select and use either one of the first scale parts 41 and 51 and the second scale parts 46 and 56. This eliminates the need to convert between the volume and weight of the drug solution 61, so that the burden on the medical site can be reduced.

The method of using the prefilled syringe 10 will be described more specifically. Referring to FIG. 1, when the prefilled syringe 10 is not used, 10 mL (50 mg) of the drug solution 61 is loaded in the barrel 21. At this time, the tip of the plunger 31 indicates 10 mL of the first scale portion 41 of the barrel 21, and indicates 50 mg of the second scale portion 46 of the barrel 21. The rear end of the barrel 21 indicates 0 mL of the first scale portion 51 of the plunger 31 and 0 mL of the second scale portion 56 of the plunger 31.

Referring to FIG. 5, either one of first scale portion 51 and second scale portion 56 of plunger 31 is used according to the type of dose described in the use manual when administering drug solution 61 to the patient. .. For example, when the dose of the drug solution 61 is described as 7 mL in the usage manual, the plunger 31 is moved so that the rear end of the barrel 21 points to 7 mL of the first scale portion 51 of the plunger 31. When the dose of the drug solution 61 is described as 35 mg in the usage manual, the plunger 31 is moved so that the rear end of the barrel 21 points to 35 mg of the second scale portion 56 of the plunger 31.

After the administration of the drug solution 61 to the patient, the remaining amount of the drug solution 61 in the barrel 21 is confirmed to confirm that the drug has been administered at an appropriate dose. At this time, it is possible to confirm that the residual amount of the chemical liquid 61 is 3 mL by using the first graduation portion 41 of the barrel 21, and the residual amount of the chemical liquid 61 can be confirmed by using the second graduation portion 46 of the barrel 21. It can be confirmed that the amount is 15 mg.

6 to 8 are perspective views showing modified examples of the prefilled syringe in FIG. The volume of the prefilled syringe shown in FIG. 6 is 1.0 mL (20 mg), the volume of the prefilled syringe shown in FIG. 7 is 5 mL (100 mg), and the volume of the prefilled syringe shown in FIG. 8 is 20 mL. (100 mg).

Also in the prefilled syringe shown in FIG. 6 to FIG. 8, the barrel 21 is provided with the first scale portion 41 for measuring the volume of the chemical liquid 61 and the second scale portion 46 for measuring the weight of the chemical liquid 61. The plunger 31 is provided with a first scale portion 51 for measuring the volume of the chemical liquid 61 and a second scale portion 56 for measuring the weight of the chemical liquid 61. In each prefilled syringe, the first graduated portions 41, 51 and the second graduated portions 46, 56 are configured so as to match the conversion of the amount of the drug solution contained in the barrel 21.

In addition, although the case where the scale numbers 43 and 48 and the scale numbers 53 and 58 are attached so as to increase from the distal side to the proximal side has been described in the present embodiment, the present invention is not limited to this. .. For example, graduated numbers 43 and 48 are attached to the barrel 21 so as to increase from distal to proximal, and graduated numbers 53 and 58 are attached to the plunger 31 so as to increase from proximal to distal. May be configured. Further, the first scale part and the second scale part may be provided only on one of the barrel 21 and the plunger 31.

Further, the liquid loaded into the syringe in the present invention is not particularly limited, and may be, for example, insulin or physiological saline. Furthermore, in the present invention, the types of liquid measurement by the first scale portion and the second scale portion are not limited to volume and weight. For example, when the liquid loaded in the syringe is an anticancer drug, it may be a titer (KU) and a volume (mL). Further, when the liquid loaded in the syringe is insulin, it may be in unit and volume (mL).

Further, in the present embodiment, the prefilled syringe preloaded with the drug solution has been described, but the present invention may be a syringe loaded with the drug solution when administering the drug solution to the patient. In this case, the first graduation portion and the second graduation portion may be configured so as to match the conversion of the measurement of the drug solution to be loaded in the syringe.

The embodiments disclosed this time are to be considered as illustrative in all points and not restrictive. The scope of the present invention is shown not by the above description but by the claims, and is intended to include meanings equivalent to the claims and all modifications within the scope.

The present invention is mainly applied to syringes and prefilled syringes used in the medical field.

10 Prefilled Syringe, 21 Barrel, 22 Main Body Part, 23 Chemical Solution Discharge Part, 24, 33 Flange Part, 24p, 24q Finger Hooking Part, 31 Plunger, 32 Shaft Part, 32a First Surface, 32b Second Surface, 36 Gasket, 41 , 51 1st scale part, 42, 47, 52, 57 scale, 46, 56 2nd scale part, 43, 48, 53, 58 scale number, 44, 49, 54, 59 scale unit, 61 chemical liquid, 101 center.

Claims (4)

A barrel configured to be able to place a liquid,
A plunger inserted into the barrel,
It said barrel and said plunger over includes a first scale part for metering liquids, and a second scale part for metering the liquid is provided,
The type of metering of liquid by said first scale part, and the type of metering of liquid by the second scale part is, unlike each other,
The first graduation portion and the second graduation portion include graduation numbers,
In the axial direction of the syringe, the position closer to the part that ejects liquid is called distal, and the position farther from the part that ejects liquid is proximal.
In the first graduation portion and the second graduation portion provided on the barrel, and the first graduation portion and the second graduation portion provided on the plunger, the graduation number is from the distal to the proximal. Syringe that is attached so as to become larger toward . The kind of measurement by the first scale part is the volume of liquid,
The syringe according to claim 1, wherein the type of measurement by the second scale portion is the weight of the liquid. The plunger includes a shaft portion having a cross-shaped cross section,
The shaft portion is disposed on both sides of the center of the cross shape and has a first surface and a second surface extending in the same plane,
The syringe according to claim 1 or 2 , wherein the first graduated portion and the second graduated portion are provided on the first surface and the second surface, respectively. A syringe according to any one of claims 1 to 3 ,
A liquid filled in the barrel,
The prefilled syringe, wherein the first graduated portion and the second graduated portion are configured so as to match the conversion of the measurement of the liquid between the first graduated portion and the second graduated portion.

Images