JP6775314B2 - Residual chlorine scavenger, residual chlorine scavenging bath composition, and residual chlorine scavenging skin cosmetics - Google Patents

Description

The present invention relates to a residual chlorine scavenger, a bath composition, and a skin cosmetic.

Traditionally, an increasing number of people have some skin problems due to skin diseases such as atopic dermatitis. Examples of the method for treating the disease include a method for keeping the affected area clean by taking a bath.
However, most of the tap water generally used for bathing is chlorinated, and the tap water contains residual chlorine. Therefore, bathing with tap water has a problem that it is strongly irritating to people having the skin disease.
In addition, the water generally used for pools is disinfected with a higher concentration of chlorine than tap water, and for people with the above-mentioned skin diseases, there is a problem that it is more irritating than tap water in bathing. there were.

In order to solve the above problems, a residual chlorine scavenger containing a medicinal plant extract has been proposed (see, for example, Patent Documents 1 and 2). However, in the above proposal, only a few types such as Angelica acutiloba and chamomile are known. Therefore, a residual chlorine scavenger having an excellent residual chlorine scavenging action other than the above-mentioned proposal and having high safety is desired.

Japanese Unexamined Patent Publication No. 2000-70956 JP-A-2002-346575

An object of the present invention is to solve the above-mentioned problems in the past and to achieve the following object. That is, an object of the present invention is to provide a residual chlorine scavenger having an excellent residual chlorine scavenging action and having high safety.

As a result of diligent studies by the present inventor in order to solve the above problems, it was found that the peach extract has an excellent residual chlorine scavenging effect.

The present invention is based on the above-mentioned findings by the present inventor, and the means for solving the above-mentioned problems are as follows. That is,
<1> A residual chlorine scavenger characterized by containing a peach extract.
<2> The residual chlorine scavenger according to <1>, wherein the peach extract is an extract of peach leaves.
<3> A bath preparation composition containing the residual chlorine scavenging agent according to any one of <1> to <2>.
<4> A skin cosmetic containing the residual chlorine scavenger according to any one of <1> to <2>.

According to the present invention, it is possible to solve the above-mentioned problems in the prior art, achieve the above object, have an excellent residual chlorine scavenging action, and provide a highly safe residual chlorine scavenging agent.

FIG. 1 is a calibration curve for the absorbance at 510 nm and the chlorine concentration in the examples.

(Residual chlorine eliminator)
The residual chlorine scavenger of the present invention contains a peach extract and, if necessary, other components.

<Peach extract>
The peach (Amygdalus persica L.) is a deciduous small tree of the genus Rosa in the family Rosaceae, and is native to China. The peaches are cultivated all over the world for food and ornamental purposes. The seeds of the peach are called "Tounin" and are used in medicines, and the leaves of the peach are said to be effective for skin inflammation.

The peach extract can be easily obtained by using a method generally used for extracting plants. The peach extract includes an extract of the peach, a diluted solution or a concentrated solution of the extract, a dried product of the extract, or a crude or purified product thereof.

The extraction site of the peach is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include fruits, seeds, leaves, bark, flowers and roots. Of these, leaves are preferred.

As a method for preparing the extraction site of the peach, it can be obtained by drying each site and then crushing the site as it is or using a crusher and subjecting it to solvent extraction. The drying may be carried out in the sun or may be carried out using a commonly used dryer.

The method for extracting the peach is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a method of extracting using an arbitrary extraction device at room temperature or under reflux heating. As an example, peach as an extraction raw material is put into a treatment tank filled with an extraction solvent, and if necessary, it is allowed to stand for 30 minutes to 2 hours with occasional stirring to elute soluble components, and then filtered. Then, the solid matter is removed, the extraction solvent is distilled off from the obtained extract, and the extract is dried to extract the extract.

The solvent used for extracting the peach is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include water, a hydrophilic organic solvent, and a mixed solvent thereof.

The water that can be used as the extraction solvent for the peach is not particularly limited and may be appropriately selected depending on the intended purpose. For example, pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, etc. In addition to fresh water, those that have undergone various treatments are included. Treatments applied to water include, for example, purification, heating, sterilization, filtration, ion exchange, osmotic pressure adjustment, buffering and the like. The water that can be used as the extraction solvent includes purified water, hot water, ion-exchanged water, physiological saline, phosphate buffer, phosphate buffered saline and the like.

The hydrophilic organic solvent that can be used as the extraction solvent for the peach is not particularly limited and may be appropriately selected depending on the intended purpose. For example, methanol, ethanol, propyl alcohol, isopropyl alcohol and the like have 1 to 5 carbon atoms. Lower alcohols; lower aliphatic ketones such as acetone and methyl ethyl ketone; polyhydric alcohols having 2 to 5 carbon atoms such as 1,3-butylene glycol, propylene glycol and glycerin, and the like, and these hydrophilic organic solvents and water A mixed solvent or the like can also be used. When a mixed solvent of the water and the hydrophilic organic solvent is used, 1 part by mass to 90 parts by mass with respect to 10 parts by mass of water in the case of lower alcohol, and 10 parts by mass of water in the case of lower aliphatic ketone. It is preferable to use a mixture of 1 part by mass to 40 parts by mass with respect to parts by mass. In the case of polyhydric alcohol, it is preferable to use a mixture of 1 part by mass to 90 parts by mass with 10 parts by mass of water.

The peach extraction conditions are not particularly limited and may be appropriately selected depending on the intended purpose. However, the amount of the extraction solvent is preferably 5 to 15 times the amount (mass ratio) of the extraction raw material, and the extraction solvent. When water is used as the extraction solvent, extraction is preferably performed at 50 ° C. to 95 ° C. for about 1 hour to 4 hours, and when a mixed solvent of water and ethanol is used as the extraction solvent, 40 ° C. to 90 ° C. is used. It is preferable to extract in about 30 minutes to 4 hours.

The method for purifying the peach extract is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include liquid-liquid partition extraction, various chromatographys, and membrane separation.

<Other ingredients>
The other components are not particularly limited and may be appropriately selected depending on the intended purpose. For example, excipients, moisture-proofing agents, preservatives, strengthening agents, thickeners, emulsifiers, antioxidants, sweeteners. , Acidulants, seasonings, colorants, fragrances, whitening agents, moisturizers, oily ingredients, UV absorbers, surfactants, thickeners, alcohols, powder ingredients, coloring agents, aqueous ingredients, water, skin nutrition Examples include agents.
The specific examples of the other components are not particularly limited and may be appropriately selected depending on the intended purpose. For example, hyaluronic acid, hyaluronic acid hydrolyzate, collagen, collagen hydrolyzate, ascorbic acid, ascorbin Acid derivative, ascorbic acid glycoside, coenzyme Q10, propolis, royal jelly, royal jelly hydrolyzate, fucoidan, aloe powder, aloe extract, blueberry powder, blueberry extract, isoflavone, noni powder, noni extract, garlic powder, garlic Extracts, Ukon powder, Ukon extract, Chitosan, Glucosamine, Chlorella powder, Chlorella extract, Carnitine, Maca powder, Maca extract, Cassis powder, Cassis extract, Hanabira bamboo powder, Hanabira bamboo extract, and other plant powders / Or an extract or the like.

<Dosage form>
The dosage form of the residual chlorine scavenger of the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include tablets, powders, capsules, granules and extracts.

<Use>
Since the residual chlorine scavenger of the present invention has an excellent residual chlorine scavenging action, it is used as, for example, a skin cosmetic, a bathing agent composition, a filler for a shower head, a filler used for a water purifier for beverages, and the like. Among these, bath preparation compositions and skin cosmetics are preferable.

(Bath composition)
The bath preparation composition of the present invention may contain the residual chlorine scavenger of the present invention, and may further contain other components if necessary.

<Residual chlorine eliminator>
As the residual chlorine scavenger, the residual chlorine scavenger of the present invention described above can be used.
The content of the residual chlorine scavenger is not particularly limited and may be appropriately selected depending on the intended purpose.

<Other ingredients>
The other components are not particularly limited as long as they are usually used in a bath composition, and can be appropriately selected depending on the intended purpose. For example, inorganic acids, organic acids, oily components, crude drugs and medicinal products can be selected. Examples include plants and their extracts, pigments, vitamins, water-soluble polymers, surfactants, proteolytic enzymes, moisturizers, fragrances and the like. These may be used alone or in combination of two or more.

Examples of the inorganic acids include sodium chloride, sodium hydrogencarbonate, sodium carbonate, borosand, sodium sulfate, sodium sulfide, sodium sesquicarbonate, sodium nitrate, sodium thiosulfate, sodium polyphosphate, sodium phosphate, calcium oxide, and oxidation. Inorganic salts such as magnesium, calcium carbonate, magnesium carbonate, potassium chloride, potassium sulfide, boric acid, metasilicic acid, silicic anhydride and the like can be mentioned.
Examples of the organic acids include succinic acid, fumaric acid, malic acid, tartaric acid, citric acid, benzoic acid and the like.

The oily component is contained to enhance the heat retaining effect.
Examples of the oily component include soybean oil, rice bran oil, rice germ oil, jojoba oil, avocado oil, almond oil, olive oil, cacao butter, sesame oil, sunflower oil, palm oil, mink oil, beef fat, and pork fat. Natural fats and oils; Hardened oils obtained by hydrogenating the natural fats and oils; Fats and oils such as synthetic triglycerides such as myristic acid glyceride and glycerin 2-ethylhexanoate; Rows such as carnauba wax, whale wax, honey wax and lanolin; , Carbohydrates such as vaseline, paraffin, selecin, squalane; higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, lanolinic acid, isostearic acid; lauryl alcohol, cetyl Higher alcohols such as alcohol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol; cetyl octanoate, myristyl lactate, cetyl lactate, isopropyl myristate, myristyl myristate, isopropyl palmitate, isopropyl adipate, butyl stearate, oleic acid Esters such as decyl; peppermint oil, jasmine oil, cypress oil, hinoki oil, peppermint oil, kehi oil, bergamot oil, orange oil, shove oil, pine oil, lavender oil, clove oil, hiba oil, rose oil, eucalyptus oil , Lemon oil, thyme oil, peppermint oil, rose oil, sage oil, menthol, cineole, eugenol, citroneral, linalol, geraniol, camphor, timol, pinen, limonene and other essential oils.

Examples of the crude drug, medicinal plant, and extract thereof include fennel, phellodendron amur, cinnamon bark, red flower, shakuyaku, ginger, iris, chenpi, sojutsu, valeriana, biakshi, tohi, mint, and bukuryo.
Examples of the pigments include tar dyes specified by the Ordinance of the Ministry of Health and Welfare (1) of Yellow No. 4, Blue No. 1, and Yellow No. 202. Synthetic pigments such as Appendix Tables 1 and 2; Examples thereof include natural pigments recognized as food additives of the same kind.
Examples of the vitamins include various vitamins such as vitamin A, vitamin C, vitamin D and vitamin E, and derivatives thereof.
Examples of the water-soluble polymer include sodium alginate, propylene glycol alginate, arabic gum, xanthan gum, pectin, sodium carboxymethyl cellulose, methyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, milk protein, soybean protein, gelatin, egg protein, sodium caseinate and the like. Can be mentioned.

The surfactant acts as an emulsifier for the oily component.
Examples of the surfactant include anionic surfactants and nonionic surfactants. Among these, nonionic surfactants are preferable from the viewpoint of less skin irritation. In addition, examples of the surfactant include natural surfactants and synthetic surfactants. Among these, natural surfactants are preferable from the viewpoint of less skin irritation.
Examples of the nonionic surfactant include glycerin fatty acid ester, propylene glycol fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, tetraoleic acid polyoxyethylene sorbit, polyoxyethylene propylene glycol, and polyoxyethylene himashi. Examples thereof include oil, polyoxyethylene hydrogenated castor oil, and polyglycerin fatty acid ester.

The content of the other components is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 0 parts by mass to 200 parts by mass with respect to 100 parts by mass of the residual chlorine scavenger.
Examples of the bathing agent composition include cosmetic bathing agents whose main purpose is odor and coloring, pharmaceuticals whose main purpose is a hot bath effect, bathing agents as quasi-drugs, and the like. It is possible.
The dosage form of the bath preparation composition is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include powder, tablets, granules, bath oil and bubble bath.
The amount of the bathing agent composition to be used is not particularly limited and may be appropriately selected depending on the intended purpose, but it is preferably used in a ratio of 20 g to 30 g with respect to about 200 L of hot water.

(Skin cosmetics)
The skin cosmetic of the present invention may contain the residual chlorine scavenger of the present invention, and may further contain other components if necessary.
As the residual chlorine scavenger, the residual chlorine scavenger of the present invention described above can be used.
The content of the residual chlorine scavenger is not particularly limited and may be appropriately selected depending on the intended purpose.

<Other ingredients>
The other ingredients are not particularly limited as long as they are usually used in skin cosmetics, and can be appropriately selected depending on the purpose. For example, an astringent, a bactericide, an antibacterial agent, an ultraviolet absorber, a moisturizer, etc. Examples thereof include cell activators, fats and oils, waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants and fragrances. These may be used alone or in combination of two or more.
The content of the other components is not particularly limited and may be appropriately selected depending on the intended purpose.

Examples of the present invention will be described below, but the present invention is not limited to these examples.

<Measurement of residual chlorine concentration>
Residual chlorine concentration was measured by diethyl-p-phenylenediamine (DPD). When DPD reacts with chlorine, it develops a pink to pink red color. The degree of color development can be measured by measuring the absorbance at a wavelength of 510 nm.
In the examples of the present invention, as the DPD, a solution obtained by diluting a rapid DPD reagent (manufactured by Kanto Chemical Co., Inc.) with purified water to 100 mg / L was used (hereinafter, referred to as "DPD solution"). is there).

-Creation of calibration curve-
A 891 mg / mL potassium permanganate solution was diluted 900-fold with purified water. The diluted potassium permanganate solution corresponds to 1.11 mg / L in terms of chlorine concentration. Further, this solution was diluted 2-fold, 4-fold, 8-fold, 16-fold, and 32-fold with purified water to prepare a solution.
900 μL of each prepared diluted solution was put into a test tube, 100 μL of the DPD solution was put in, and after mixing well, the absorbance at 510 nm was immediately measured, and a calibration curve having an initial concentration of 1 mg / L was prepared. The results are shown in FIG.

(Example 1)
As the residual chlorine scavenger, a peach extract (peach extract BG-J, manufactured by Maruzen Pharmaceuticals Co., Ltd., solid content 1.9% by mass) was used. It was diluted with purified water so that the concentration of the residual chlorine scavenger was 0.1% by mass. 890 μL of tap water, 10 μL of the residual chlorine scavenger, and 100 μL of the DPD solution were added to a test tube and mixed, and then the absorbance of the mixed solution at 510 nm was measured. The value of the residual chlorine concentration was measured based on the calibration curve of FIG. Was calculated. The final concentration of the residual chlorine scavenger in Example 1 was 0.001% by mass. The results are shown in Table 1.

(Example 2)
In Example 1, the absorbance of the mixed solution was measured in the same manner as in Example 1 except that the concentration of the residual chlorine scavenger was changed from 0.1% by mass to 1% by mass, and based on the calibration curve of FIG. , The residual chlorine concentration was calculated. The final concentration of the residual chlorine scavenger in Example 2 was 0.01% by mass. The results are shown in Table 1.

(Example 3)
In Example 1, the absorbance of the mixed solution was measured in the same manner as in Example 1 except that the concentration of the residual chlorine scavenger was changed from 0.1% by mass to 10% by mass, and based on the calibration curve of FIG. , The residual chlorine concentration was calculated. The final concentration of the residual chlorine scavenger in Example 3 was 0.1% by mass. The results are shown in Table 1.

(Comparative Example 1)
In Example 1, the absorbance of the mixed solution was measured and the residual chlorine concentration was calculated in the same manner as in Example 1 except that the residual chlorine scavenger was replaced with purified water. The final concentration of the residual chlorine scavenger in Comparative Example 1 was 0% by mass. The results are shown in Table 1.

<Elimination rate of residual chlorine>
Next, the elimination rate (%) of residual chlorine was calculated from the absorbance values of Examples 1 to 3 and Comparative Example 1 by the following formula. The results are shown in Table 1.
Erasure rate (%) = (CA) / C × 100
C: Absorbance at 510 nm of Comparative Example 1 A: Absorbance of Examples 1 to 3 at 510 nm

From the results in Table 1, the peach extracts of Examples 1 to 3 had a lower residual chlorine concentration than that of Comparative Example 1. Therefore, it was found that the residual chlorine scavenger of the present invention exhibits a high residual chlorine scavenging effect.

Since the residual chlorine scavenger of the present invention has an excellent residual chlorine scavenging effect, it is suitably used as, for example, a filler used in skin cosmetics, bath preparation compositions, shower head fillers, and beverage water purifiers. Of these, bathing composition and skin cosmetics are particularly preferred.

Claims (3)

Residual chlorine scavenger characterized by containing a mixed solvent extract of peach leaf water and a hydrophilic solvent as an active ingredient (provided that peach leaf hot water extract, peach flower extract, or peach Except for those containing immature fruit extract of peach as an active ingredient) . A bath preparation composition for erasing residual chlorine, which comprises the residual chlorine scavenging agent according to claim 1. A skin cosmetic for eliminating residual chlorine, which comprises the residual chlorine eliminating agent according to claim 1.