JP6362225B2 - Pest repellent - Google Patents

Description

  The present invention relates to a novel pest repellent.

  Conventionally, as insect repellents, N, N-diethyl-m-toluamide (DEET) or pyrethroid compounds (pyrestrin, cinerine, jasmolin, allethrin, tetramethrin, resmethrin, flamethrin, phenothrin, permethrin, contained in insect repellent sprays or insecticides, Ciphenothrin, veratrine, etofenprox, cyfluthrin, tefluthrin, bifenthrin, silafluophene) have been proposed, but there were problems with safety and odor.

  For example, DEET has been used worldwide for decades, but there are cases of low dose DEET affecting the nervous system, and now it is restricted when used in children (under 12 years) Is provided. (Non-Patent Document 1).

Further, DEET or pyrethroid compounds are volatile, and there is a problem that when the components are applied to the fiber structure and then heat-treated at a high temperature, the components are not evaporated and remain on the fibers.
On the other hand, it is known that some compounds (for example, monoterpene compounds) contained in plant essential oil exhibit a pest repellent effect. For example, Patent Document 1 includes, as a pest repellent component (A), citronellal and one or more selected from terpineol, menthol, limonene, geraniol, citronellol, camphene, etc., and the pest repellent component (A) A pest repellent volatilization composition having a citronellal content of 2 to 10% by mass is disclosed.

  Patent Document 2 discloses an insect repellent for clothing containing a naturally occurring component terpinen-4-ol as an active ingredient.

  Furthermore, Patent Document 3 discloses a mosquito repellent containing β-phenylethyl alcohol or methyl dihydrojasmonate as an active ingredient. Although these are compounds contained in plant essential oils or compounds used as perfumes and are highly safe, there are cases where sustainability still remains due to high volatility.

  For example, when pest repellent effects are sought for textile products, paints, household goods, wall materials, etc., repellents with low odor, low volatility and high long-term sustainability are required.

  Among the terpene compounds, for example, borneol, citral, citronellal, citronellol, limonene, geraniol, linalool, menthol, terpineol, thymol, etc., each component has a repellent effect, but because it is highly volatile During heating when processing fibers, sundries, etc., these residual rates are lowered.

  On the other hand, Patent Document 4 discloses a fiber pest repellent containing 2-phenoxyethanol and / or 2-dihydroterpinyloxyethanol as an active ingredient. These are virtually odorless to suit consumer preferences but can only be addressed by certain pests.

JP 2003-201203 A Japanese Patent Laid-Open No. 06-227906 JP 05-208902 A JP 2001-199806 A

Ministry of Health, Labor and Welfare, Pharmaceutical Foods Bureau Safety Measures Section, Safety Measures for Drugs and Quasi-drugs Containing Diet, [online], August 24, 2005, http://www.mhlw.go.jp/topics/ 2005/08 / tp0824-1.html

  An object of the present invention is to provide a pest repellent having high safety and high durability.

  The active ingredient of the pest repellent of the present invention is a derivative of α-terpineol represented by the formula (1) (wherein n represents either 1 or 2; R represents either methyl or hydrogen). It is.

  This can be produced by reacting α-pinene contained in natural essential oils such as turpentine and glycols such as ethylene glycol, diethylene glycol and propylene glycol.

  Specifically, 2-terpinyloxyethanol, 2-terpinyloxyisopropanol, 2-terpinyloxyethyleneoxyethanol, etc. are targeted. In particular, 2-terpinyloxyethanol has almost no odor and is commercially available as a high boiling point solvent, a perfume retaining agent, and a metal paste / glass paste solvent.

  According to the present invention, it is possible to provide a pest repellent that has the compound as an active ingredient and is odorless and excellent in sustainability.

  The compound of the present invention is a part of a derivative of a terpene compound that has high repellency against pests such as mosquitoes, ticks, and clothing pests, but is highly safe against the human body.

  Among the compounds that are active ingredients of the present invention is the compound 2-terpinyloxyethanol, which is commercially available for use as a solvent or the like.

The pest repellent of the present invention is prepared by combining with carriers and components used in ordinary pest repellents and preparing a formulation.

For example, the pest repellent of the present invention can be made into a liquid preparation as it is or by dissolving or solubilizing it in a solvent. As the solvent, alcohols, glycols, hydrocarbons, glycol ethers, water and the like can be used. A surfactant, a thickener, etc. can be added and adjusted as necessary so that the active ingredient of the present invention is uniformly dispersed. This liquid preparation can be used as it is in a container, or as a liquid-core preparation that is sucked up by a suction core and volatilized, or into a container having an osmotic permeability film and volatilized through the film, or a gelling agent is added. Gel preparation. Depending on the object, it is possible to apply and impregnate the liquid preparation directly on the object, or to spray the liquid preparation onto the object as a spray preparation.

Moreover, the pest repellent of the present invention can be carried on a carrier to form a solid preparation. Carriers include cellulose, rayon, polyethylene, polypropylene, polyester, polyurethane, wool, talc, clay, unglazed powder, ceramic powder, etc., granules, tablets, sheets, mats, felts, sponges, boards, paper, woven fabrics, A porous or non-porous carrier such as a nonwoven fabric or a film can be used. Examples of the supporting method include impregnation by dripping, spraying, spraying, application, printing, kneading and the like.

In preparing the pest repellent of the present invention, it can be used together with other insect repellents such as pyrethroid compounds as necessary. Moreover, arbitrary components, such as an antifungal agent, antioxidant, a ultraviolet absorber, can also be added as needed. Furthermore, if a fragrance | flavor is added suitably, the insect repellent which has a fine fragrance | flavor and the pleasant fragrance can be obtained.

  Pests to which the pest repellent of the present invention can be applied include sanitary pests, unpleasant pests, agricultural pests and the like. More specifically, for example, mosquitoes, including mosquitoes such as Culex mosquitoes, Culex mosquitoes, Chichaeka, Aedesia, etc. Flies such as Drosophilidae, Drosophila such as Drosophilidae, Drosophila, Drosophila, Fleafidae, Drosophila such as Scarlet flies, butterflies such as Drosophila and Drosophila, Chironomidae, Chironomidae Can be mentioned. These flying pests include, for example, blood-sucking insects or biting pests such as the mosquito mosquito, Aedes albopictus, Aedes albopictus, flies and tsetse flies that are known to mediate pathogens. In addition, moths such as moths and moths such as common moths and moths such as Nomememadarameiga are included, and these larvae are known as clothing pests. In addition, beetles of the cutworm beetle family, weevil family, scorpion family, and hornworm family are included, such as Himekatsuobushimushi and Himemarukatsubushimushi. These are known to cause food damage, such as crops, and some of the beetles of the cutworm beetle also cause food damage to clothing. Furthermore, examples of ticks include ticks, house mites, mites, leopard mites, dust mites, claw mites, spider mites and the like. These mites are known to have blood-sucking properties such as ticks and house mites, those that parasitize animals including humans, those that become allergens, and those that cause food damage such as food and agricultural products.

The pest repellent of the present invention may be prepared, for example, as a liquid preparation or a solid preparation. The amount of the compound used for formulation is not particularly limited, but generally 0.01 to 50% by weight per formulation is preferred.

  The pest repellent of the present invention itself is odorless and can be used in any form by being appropriately combined with auxiliary materials.

For example, as a skin external preparation, it can be used as a spray, a coating agent, or a patch. As household hygiene products, solid or liquid volatilizers, sprays, cleaning liquids, and the like can be used in combination with aromatic deodorants and antibacterial agents. It can also be used as a spray for gardening supplies. About the said usage method, in addition to adding the insect repellent of this invention, it can manufacture in accordance with the method generally performed, respectively.

  Furthermore, it can also be used as clothing, building materials, wallpaper, ornaments, etc., which have been fixed to fibers, wood, paper, ceramic materials, etc. and have added a pest repellent effect. As these immobilization methods, known methods such as liquid agent impregnation, spraying, microencapsulation and the like can be used.

  Hereinafter, the present invention will be described in more detail with reference to examples. The repelling rate in this example was determined by the following method.

(1) Repelling rate of Aedes albopictus
Put a thick cotton work gloves on the subject's hand, and then put a cotton inner gloves on top of it, wrap a 30 x 30 cm specimen on it, and fasten it with a rubber band so that it does not become as wrinkled as possible.
Insert the tip of the wrist into a 28 x 28 x 28 cm full-length nylon goose-clad cage that has released human striped mosquitoes, and count the number of test insects that have stopped on the specimen three times a minute. To do.

In the test, after counting the number of untreated specimens accumulated, the test insects are rested for about 20 minutes, and when the specimen is wrapped, the number of treated areas accumulated is counted.
The following formula was used for calculation of the repelling rate.

    Repelling rate (%) = {(cumulative number of untreated samples−cumulative number of treated samples) / cumulative number of untreated samples} × 100

Example 1
Polyester fibers were immersed in a solution of 2-terpinyloxyethanol (manufactured by Nippon Terpene Co., Ltd.) in isopropyl alcohol. It dried at room temperature so that a repellent component might be 0.5 weight% with respect to a fiber. The repellent rate was 82%.

(Example 2)
In the same manner as in Example 1, a fiber containing 1.0% by weight of a repellent component with respect to the fiber was prepared. The repellent rate was 95%.

(2) Repellent rate of mushroom leopard mite Anti-mite test of textile products According to JIS L 1920 invasion prevention method repellent test. During the test period, it was observed at 25 ° C., 75% Rh, all dark, sealed, and 24 hours after the start of the test.

    Repelling rate (%) = {(cumulative tick count of untreated specimen−cumulative tick count of treated specimen) / cumulative tick count of untreated specimen} × 100

(Example 3)
Polyester fibers were immersed in a solution of 2-terpinyloxyethanol (manufactured by Nippon Terpene Co., Ltd.) in isopropyl alcohol. It dried at room temperature so that a repellent component might be 0.2 weight% with respect to a fiber.
The results of the mite prevention test are as follows: cumulative tick number of untreated specimen: 5309, cumulative tick number of treated specimen: 564. The repellent rate was 84.8%.

Claims (2)

Formula (1)

(In the formula, n represents either 1 or 2. R represents either methyl or hydrogen.) A tick repellent containing as an active ingredient the compound. A tick repellent containing 2-terpinyloxyethanol as an active ingredient.