JP6033911B2 - Nutritional emulsion containing calcium HMB and soluble protein - Google Patents

Description

  The present disclosure relates to a nutritional emulsion comprising calcium beta-hydroxy-beta-methylbutyrate (calcium HMB) and soluble proteins.

  Beta-hydroxy-beta-methylbutyrate (HMB) is a naturally occurring amino acid metabolite that is often incorporated into various nutritional products and supplements. HMB is commonly used in such products to help form or maintain healthy muscle mass and strength in selected individuals.

  HMB is a metabolite of leucine, an essential amino acid, and has been shown to regulate protein turnover and inhibit proteolysis. In most individuals, the muscle converts about 5% of the available leucine to HMB, producing about 0.2-0.4 grams of HMB per day for a 70 kg man. In studies where various types of stress were induced in animals, supplementation with HMB increased lean body mass. Clinical studies also suggest that HMB has at least two functions in recovery from disease or injury, including protecting lean body mass from stress-related injury and enhancing protein synthesis. HMB may be useful for enhancing immune function, reducing the incidence or severity of allergies or asthma, reducing total serum cholesterol and low density lipoprotein cholesterol, increasing muscle aerobic capacity and other uses Has been suggested.

  Because HMB is most often used in individuals to help develop and maintain healthy muscle mass and strength, many HMB products, along with additional nutrients that may be useful in promoting healthy muscle as well It is blended. Some of these HMB products contain additional nutrients such as fats, carbohydrates, proteins, vitamins, minerals and the like. Calcium HMB is the most commonly used form of HMB when formulated into oral nutritional products including tablets, capsules, reducible powders and nutrient solutions and emulsions. Nutritional emulsions are particularly useful in this regard. This is because such emulsions can contain a balance of fat, protein, carbohydrates, vitamins and minerals useful in helping to maintain healthy muscles.

  However, nutritional emulsions containing calcium HMB are often not physically stable over time, such emulsions are not easily stable with many protein systems, and especially when packaged and stored for long periods of time. It has not been found that protein content and / or other sediments occur in the emulsion during or after formulation.

  These nutritional emulsions containing calcium HMB have also been found to generate an undesirable bitter flavor or aftertaste after the emulsion has been packaged and stored for an extended period of at least 1 to 3 months.

  Accordingly, there is a need for a nutritional emulsion comprising calcium HMB that remains physically stable during the shelf life and / or does not generate a bitter flavor or aftertaste over time.

( Outline of disclosure )
One embodiment of the present disclosure relates to a nutritional emulsion comprising fat, carbohydrate, protein and calcium HMB, wherein the protein comprises about 50% to 100% soluble protein by weight. The soluble protein is preferably selected from sodium caseinate, whey protein concentrate and combinations thereof. Most preferred is sodium caseinate.

  Another embodiment of the present disclosure is a nutritional emulsion comprising fat, carbohydrate, protein and calcium HMB, wherein the protein comprises about 50% to 100% by weight soluble protein, and the nutritional emulsion comprises about 5%. : Relates to a nutritional emulsion having a weight ratio of soluble protein: calcium HMB of from 1 to about 12: 1.

  Another embodiment of the present disclosure is a packaged nutritional composition comprising a sealed container and a nutritional emulsion contained therein, wherein the nutritional emulsion comprises fat, carbohydrate, protein and calcium HMB, The protein comprises about 50% to about 100% soluble protein by weight and the packaging composition is stored at 18-24 ° C. for 3-24 months after formulation and packaging of the packaging composition The packaged nutritional composition.

  It has been found in the present invention that the addition of calcium HMB to a nutritional emulsion can cause the development of a bitter flavor or aftertaste. The bitter flavor or aftertaste typically occurs only when the product is manufactured, packaged, and stored for at least about 1 to about 3 months. In fact, nutritional emulsions containing calcium HMB often cause little or no bitter flavor or aftertaste when consumed within about a month (including about 1 to about 3 months after formulation) Surprisingly, it has been found in the present invention that such a bitter flavor or aftertaste occurs in the packaged product over time.

  Also, many nutritional emulsions containing calcium HMB are physically unstable, often causing excessive protein content and / or other sediment accumulation at the bottom of the emulsion container, resulting in nutrient availability and the Reduce the effective shelf life of the product.

  Also, these instability and / or flavor problems are caused by formulating soluble proteins corresponding to about 50% to 100% by weight of the total protein in the nutritional emulsion (particularly the nutritional emulsion is about 5: It has been found in the present invention that the soluble protein: calcium HMB weight ratio from 1 to about 12: 1 can be minimized or eliminated. Soluble proteins of particular use in this respect include sodium caseinate and / or whey protein concentrate, in particular sodium caseinate.

( Detailed description of disclosure )
The nutritional emulsions of the present disclosure comprise at least one ingredient, feature or element for inhibiting the occurrence of a bitter flavor or aftertaste and / or improving product stability over the shelf life, and calcium HMB. The essential features of the nutritional emulsion, as well as some of the many optional variations and additions, are described in detail below.

  Unless otherwise indicated, the term “calcium HMB” as used herein refers to beta-hydroxy-beta-methylbutyrate (also called beta-hydroxy-3-methylbutyric acid, beta-hydroxyisovaleric acid or HMB). ) Which is most typically present in the monohydrate form. All weights, ratios and concentrations used herein to characterize calcium HMB are based on the weight of calcium HMB monohydrate unless otherwise indicated.

  The term “nutritive emulsion” as used herein, unless otherwise indicated, means a liquid emulsion containing fat, protein and carbohydrate that is suitable for oral administration to humans.

  As used herein, the terms “fat” and “oil” are used interchangeably to indicate lipid substances derived or processed from plants or animals, unless otherwise indicated. These terms include such synthetic lipid substances as long as the synthetic lipid substance is suitable for oral administration to humans.

  As used herein, the term “storage stable”, unless otherwise indicated, is packaged and then at 18-24 ° C. for at least 3 months, such as about 6 months to about 24 months, and also, for example, about It refers to a nutritional emulsion that remains commercially stable after being stored for 12 months to about 18 months.

  As used herein, the term “pH stable” means that, unless otherwise indicated, the buffering action of HMB means that the pH is resistant or at least more resistant to pH reduction. To do.

  As used herein, the term “plastic”, unless otherwise indicated, means food grade plastic approved by the U.S. Food and Drug Administration or other appropriate regulatory agency, including but not limited to Examples include polyvinyl chloride, polyethylene terephthalate, high density polyethylene, polypropylene, polycarbonate and the like.

  As used herein, the terms “sterile”, “sterilized” and “sterilized” refer to infections such as fungi, bacteria, viruses, spore forms, etc. in food or on food grade surfaces, unless otherwise indicated. It means that sex factors have been reduced to the extent necessary to make such foods suitable for human consumption. Sterilization methods may include various techniques including application of heat, peroxides or other chemicals, irradiation, high pressure, filtration or combinations or variations thereof.

  All percentages, parts and ratios used herein are based on the weight of the total composition unless otherwise indicated. Unless otherwise indicated, all such weights for the listed ingredients are based on activity levels and thus do not include solvents or by-products that may be included in commercially available materials.

  All references to singular features or limitations of the present disclosure are intended to include the corresponding plurality of features or limitations, unless stated otherwise, or unless clearly contradicted by the context in which the reference is made. Is also true.

  All combinations of methods or process steps used herein may be performed in any order unless otherwise indicated, or unless the indicated combination is clearly inconsistent with the context in which it is shown. .

  Various embodiments of the nutritional emulsions of the present disclosure can also be substantially free of any optional or selected essential ingredients or features described herein. However, the remaining nutritional emulsion still needs to contain all of the required ingredients or features described herein. In this case, unless otherwise indicated, the term “substantially free” means that the selected nutritional emulsion contains less than a functional amount of optional ingredients, typically less than about 0.5% by weight, For example, it is meant to contain less than about 0.1% by weight and also contain, for example, 0% by weight of such optional or selected essential ingredients.

  The nutritional emulsions and corresponding manufacturing methods of the present disclosure are essential elements of the present disclosure described herein, and any additional or optional features described herein or useful for use in nutritional emulsion formulations. Can comprise, consist of, or consist essentially of structural elements.

Product Form The nutritional emulsion of the present disclosure is an aqueous emulsion comprising fat, protein and carbohydrate. These emulsions are flowable or beverage liquids at about 1 to about 25 ° C. and are typically in the form of oil-in-water, water-in-oil or complex aqueous emulsions, but such emulsions are , Most typically in the form of an oil-in-water emulsion having a continuous water phase and a discontinuous oil phase.

  The nutritional emulsion can be storage stable and is typically storage stable. The nutritional emulsion is typically water up to about 95% of the weight of the nutritional emulsion, such as from about 50% to about 95%, and also for example from about 60% to about 90%, and also for example about 70%. % To about 85% water.

  The nutritional emulsion, together with sufficient types and amounts of nutrients to provide a unique, primary or supplemental nutrient source or to provide a special nutritional emulsion for use in individuals suffering from a particular disease or condition It can be formulated. Thus, these nutritional emulsions can have various product densities, but typically exceed about 1.055 g / mL, such as from 1.06 g / ml to 1.12 g / ml, and also from about 1 The product density may be from 0.085 g / ml to about 1.10 g / ml.

  The nutritional emulsion may have a caloric density adapted to the ultimate user's nutritional requirements, but in most cases the emulsion is about 100 to about 500 kcal / 240 ml, such as about 150 to about 350 kcal / 240 ml, and also includes, for example, about 200 to about 320 kcal / 240 ml. These nutritional emulsions also contain calcium HMB as described below, and the amount is most typically in the range of about 0.4 to about 3.0 / 240 ml, such as about 0.75 to about 2.0. / 240 ml range, for example about 1.5 g / 240 ml.

  The nutritional emulsion may have a pH in the range of about 3.5 to about 8, but most advantageously about 4.5 to about 7.5, such as about 5.5 to about 7.3, such as about 6 .Has a pH in the range of 2 to about 7.2.

  While the serving size of the nutritional emulsion can vary depending on several variables, typical dosages range from about 100 to about 300 ml, such as from about 150 to about 250 ml, such as from about 190 ml to about 240 ml. It is.

Macronutrient The nutrient emulsion contains fats, proteins and carbohydrates. In general, any source of fats, proteins and carbohydrates known or suitable for use in nutritional products may be suitable for use in the present invention. However, such macronutrients must be compatible with the essential elements (essential elements) of the nutritional emulsion as defined herein.

  The total concentration or amount of the fat, protein and carbohydrate may vary depending on the intended user's nutritional requirements, but any other essential fat, protein and / or described herein. Such concentrations or amounts, including carbohydrate components, are most typically included in one of the following exemplary ranges.

  The carbohydrate concentration most typically ranges from about 5% to about 40%, such as from about 7% to about 30%, such as from about 10% to about 25%, by weight of the nutritional emulsion, Most typically, it ranges from about 1% to about 30% of the weight of the nutritional emulsion, such as from about 2% to about 15%, and also, for example, from about 4% to about 10%, and the protein concentration is most Typically, it ranges from about 0.5% to about 30% of the nutritional emulsion, such as from about 1% to about 15%, and also, for example, from about 2% to about 10%.

  The level or amount of carbohydrate, fat and / or protein in the nutritional emulsion may additionally or alternatively be characterized as a percentage of total calories in the nutritional composition as described in the table below.

  Non-limiting examples of suitable fats or their origin used in the nutritional emulsions described herein include coconut oil, fractionated coconut oil, soybean oil, corn oil, olive oil, safflower oil, high Oleic acid safflower oil, MCT oil (medium chain triglycerides), sunflower oil, high oleic sunflower oil, palm oil and palm kernel oil, palm olein, canola oil, marine oil, cottonseed oil and combinations thereof.

  Non-limiting examples of suitable carbohydrates or their origin used in the nutritional emulsions described herein include maltodextrin, hydrolyzed or modified starch or corn starch, glucose polymer, corn syrup, corn syrup solids , Rice-derived carbohydrates, glucose, fructose, lactose, high fructose corn syrup, honey, sugar alcohols (eg, maltitol, erythritol, sorbitol) and combinations thereof.

  Non-limiting examples of suitable proteins or sources thereof used in the nutritional emulsions described herein include hydrolyzed, partially hydrolyzed or non-hydrolyzed protein or protein sources, which are Derived from any known or appropriate source, such as milk (eg, casein, whey), animals (eg, meat, fish), cereals (eg, rice, corn), vegetables (eg, soy) or combinations thereof Can be done. Non-limiting examples of such proteins include milk protein isolates, milk protein concentrates (as described herein), casein protein isolates, whey protein, sodium or calcium caseinate, Examples include full milk, partially or fully skim milk, soy protein isolate, soy protein concentrate and the like.

Calcium HMB
The nutritional emulsion contains calcium HMB, which is formulated by the addition of calcium HMB (most typically as a monohydrate) or contains calcium and HMB in the final product. It means that it is manufactured as follows. While any source of HMB is suitable for use in the present invention as long as the final product contains calcium and HMB, such source is preferably calcium HMB, most typically As such, it is added to the nutritional emulsion during formulation.

  As used herein, the term “added (added) calcium HMB” refers to the calcium salt of HMB, most typically HMB monohydrate calcium as the source of HMB added to the nutritional emulsion. Means salt.

  Calcium HMB monohydrate is the preferred source of HMB used in the present invention, but other suitable sources include HMB as a free acid, salt, anhydrous salt, ester, lactone, or from the nutritional emulsion HMB can be included as another product form that otherwise provides a bioavailable form of HMB. Non-limiting examples of suitable HMB salts for use in the present invention include sodium, potassium, magnesium, chromium, calcium or other non-toxic salt forms of HMB salt hydrates or anhydrides. Calcium HMB monohydrate is preferred and is commercially available from Technical Source International (TSI) (Salt Lake City, Utah).

  The concentration of calcium HMB in the nutritional emulsion is up to about 10% of the weight of the nutritional emulsion, for example from about 0.1% to about 8%, and also for example from about 0.2% to about 5.0%, and It can also range, for example, from about 0.3% to about 3%, and also from about 0.4% to about 1.5%, for example.

Soluble Protein The nutritional emulsions of the present disclosure may comprise a selected amount or ratio of soluble protein to improve product stability and minimize the occurrence of bitter flavor and aftertaste during shelf life.

  The soluble protein is about 50% to 100%, such as 55% to 100%, such as about 60% to about 100%, such as about 60% to about 85%, such as about 60%, of the total protein in the nutritional emulsion. % To about 80%, and also can represent, for example, about 65% to about 75%. The concentration of soluble protein is at least about 0.5% by weight of the nutritional emulsion, such as from about 1% to about 26%, and also from about 2% to about 15%, for example from about 3% to about 10%. And also can range, for example, from about 4% to about 8%.

  The amount of soluble protein contained in the nutritional emulsion can also be characterized as a soluble protein: calcium HMB weight ratio, wherein the nutritional emulsion is at least about 3.0, such as about 4.0. Of soluble protein: calcium HMB, from about 12.0 to about 6.1 to about 12, for example from about 7.0 to about 11.0, and also for example from about 8.0 to about 10.0. Includes weight ratio.

  The term “soluble protein” as used herein, unless otherwise indicated, has a solubility of at least about 90% as measured by a Protein Solubility Measurement Test comprising the following steps: Means protein: (1) the protein is suspended in water at 2.00% (w / w), (2) vigorously stirred at 20 ° C. for 1 hour to form a suspension; An aliquot of the suspension is removed and the protein concentration as total protein is determined, (4) the suspension is centrifuged at 31,000 × g and 20 ° C. for 1 hour, (5) the protein concentration in the supernatant (Soluble protein) is determined and (6) the soluble protein is expressed as a ratio to total protein.

  Any soluble protein source is suitable for use in the present invention so long as it meets the solubility requirements set forth herein. Some of these non-limiting examples include sodium caseinate (> 95% solubility when measured by protein solubility test), whey protein concentrate (when measured by protein solubility test> 90% solubility) and combinations thereof. Non-soluble proteins can of course also be included in the nutritional emulsion. However, the remaining soluble protein components need to be expressed consistent with the requirements described herein.

  Soluble proteins suitable for use in the present invention can also be characterized by the content of phosphoserine in the protein, wherein the soluble protein in this case is at least about 100 mmol per kilogram of protein, for example about 150- It is defined as a protein having 400 mmol, such as about 200 to about 350 mmol, and also for example about 250 to about 350 mmol phosphoserine.

  Where the soluble protein is defined in terms of phosphoserine content, the weight ratio of soluble protein (having the defined phosphoserine content): calcium HMB is at least about 3: 1, eg, at least about 5: 1, and also, eg, at least about It has been found that it can be 7: 1, and also for example from about 9: 1 to about 30: 1. In this case, the protein having the required content of phosphoserine is most typically in the form of a monovalent caseinate such as sodium caseinate, potassium caseinate and combinations thereof.

  In one embodiment, the soluble protein is at least about 0.2, such as from about 0.2 to about 2.0, and also, for example, from about 0.25 to 1.7 monovalent caseinate phosphoserine: calcium. It can also be characterized by the molar ratio of HMB monohydrate.

  However, it should be understood that any phosphoserine-containing protein is suitable for use in the present invention. However, it is required to have the required phosphoserine content and that the phosphoserine used to calculate the ratio is not bound, complexed or attached to a multivalent cation such as calcium or magnesium.

  Also, the alternative definition described herein with respect to the soluble protein allows little or no phosphoserine content so that the soluble protein fraction of the composition may include soluble protein with and / or without phosphoserine. It should be noted that proteins can be included that do not have any. Thus, the soluble protein used in the present invention may be defined by one or more of any characterization of soluble protein used alone or in combination.

  Thus, the phosphoserine moiety in the protein may be available for binding to calcium released from calcium HMB. Thus, the ratio of soluble protein: calcium HMB is the ratio of proteins that are unbound or unattached or that contain a phosphoserine moiety available for binding to soluble calcium from calcium HMB during formulation. For example, a mixture of calcium caseinate and sodium caseinate is used in the composition, but the ratio of protein defined by phosphoserine content to calcium HMB is the protein fraction from sodium caseinate and even calcium. Calculated based on any protein from the unbound calcium caseinate fraction.

Soluble calcium binding capacity The nutritional emulsions, in order to minimize an improved bitter taste and temporal occurrence of aftertaste product stability, solubility calcium binding capacity for the total soluble calcium in the emulsion of (SCBC), were selected A weight ratio may be included.

The ratio of the soluble calcium binding capacity (as defined herein) to the total soluble calcium of the nutritional emulsion is at least about 2.3, such as about 2.3 to about 12.0, such as about 3. 0 to about 8.0, and also for example a weight ratio of about 4.0 to about 6.5, where the ratio is determined by the following formula:
Ratio = SCBC / [soluble calcium]
SCBC = (0.32 × [soluble citrate] +0.63 [soluble phosphate] + 0.013 × [soluble protein])

  The weight ratio of SCBC to the total soluble calcium concentration should minimize the concentration of unbound calcium in the nutritional emulsion to improve product stability and reduce the occurrence of bitter flavor and aftertaste over time or It can be adjusted to minimize the weight ratio of such unbound calcium to HMB in the nutritional emulsion.

  The nutritional emulsions of the present disclosure include calcium as a desirable ingredient in the nutritional emulsion suitable for use in healthy muscle development or maintenance in the intended individual. Part or all of the calcium can be provided by the addition of calcium HMB as described herein. However, any other calcium source can be used as long as such other source is compatible with the essential elements (essential elements) of the nutritional emulsion.

  The concentration of calcium in the nutritional emulsion is typically greater than about 10 mg / L, also from about 25 mg / L to about 3000 mg / L, such as from about 50 mg / L to about 500 mg / L, and also, for example, from about Concentrations from 100 mg / L to about 300 mg / L can be included.

  In order to minimize taste and stability problems in the nutritional emulsion, calcium is formulated to minimize the degree to which the calcium is solubilized in the emulsion. Accordingly, the solubilized calcium concentration in the nutritional emulsion is less than about 900 mg / L, such as less than about 700 mg / L, such as from about 500 mg / L to about 700 mg / L, and also such as from about 400 mg / L to about 600 mg / L. It can be. In this case, the term “solubilized calcium” means free, ionized or supernatant calcium in the nutritional emulsion as measured at 20 ° C.

  Calcium in the nutritional emulsion is 5.0 or less, such as 4.0 or less, and for example 3.0 or less, and also from about 0.8 to about 3.0, solubilized citrate: solubilized calcium ratio. (Based on equivalent weight). In this case, the terms “solubilized citrate” and “solubilized calcium” mean the equivalents of citrate and calcium cation, respectively, present in the supernatant of the nutritional emulsion when measured at 20 ° C.

  The calcium component of the nutritional emulsion corresponds to 900 mg / L, for example less than 700 mg / L, and also for example less than 600 mg / L, and also for example 400 mg / L to 700 mg / L (per liter of the nutritional emulsion) It can also be characterized by solubilized calcium levels. In this case, the weight ratio of calcium HMB: solubilized calcium ranges from about 6 to about 15, such as from about 6 to about 12, such as from about 6 to about 10, and also such as from about 6 to about 8.

Vitamin D
The nutritional emulsions of the present disclosure may further include vitamin D to help maintain healthy muscle in the intended user. Vitamin D forms include vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), or other forms suitable for use in nutritional products.

  The amount of vitamin D in the nutritional emulsion is most typically up to about 1000 IU, more typically about 10 to about 600 IU, more typically about 50 to 400 IU per donation of the nutritional emulsion. Range.

Optional Ingredients The nutritional emulsions described herein may further modify physical, chemical, pleasure or processing properties, or when used in the intended population Other optional ingredients that may serve as ingredients may be included. A number of such optional ingredients are known or suitable for use in other nutritional products and may also be used in the nutritional emulsions described herein. However, such optional ingredients must be safe and effective for oral administration and compatible with the essential and other ingredients in the selected product form.

  Non-limiting examples of such optional ingredients include preservatives, antioxidants, emulsifiers, buffers, pharmaceutically active substances, additional nutrients (as described herein), colorants, flavors. Agents, thickeners and stabilizers.

  The nutritional emulsion may further contain vitamins or related nutrients, non-limiting examples of which include vitamin A, vitamin E, vitamin K, thiamine, riboflavin, pyridoxine, vitamin B12, carotenoids, niacin, folic acid , Pantothenic acid, biotin, vitamin C, choline, inositol, salts and derivatives thereof, and combinations thereof.

  The nutritional emulsion may further contain minerals, non-limiting examples of which include phosphorus, magnesium, iron, zinc, manganese, copper, sodium, potassium, molybdenum, chromium, selenium, chloride and their Combinations can be included.

  The nutritional emulsion may also include one or more flavoring agents that reduce or reduce the occurrence of any residual bitter flavor and aftertaste in the emulsion over time. Suitable flavoring agents include natural and artificial sweeteners, sodium sources such as sodium chloride, and hydrocolloids such as guar gum, xanthan gum, carrageenan, gellan gum and combinations thereof. The amount of flavoring agent in the nutritional emulsion may vary depending on the individual flavoring agent selected, the other ingredients in the formulation and other formulation or product subject variables. However, such amounts are most typically at least about 0.1%, such as from about 0.15% to about 3.0%, and also, for example, from about 0.18% to the weight of the nutritional emulsion. The range is about 2.5.

Production Method The nutritional emulsion used in the present invention may be produced by any known or suitable method for producing a nutritional emulsion, such as a milk-based nutritional emulsion.

  In one suitable manufacturing method, at least three separate slurries are prepared including a protein in fat (PIF) slurry, a carbohydrate-mineral (CHO-MIN) slurry, and a protein-in-water (PIW) slurry. PIF slurry heats and mixes selected oils (eg, canola oil, corn oil, etc.), then emulsifiers (eg, lecithin), fat-soluble vitamins and a portion of total protein (eg, milk protein concentrate, etc.) ) Under continuous heating and stirring. CHO-MIN slurries contain traces and ultra trace minerals (TM / UTM premix), thickening or suspending agents (eg Avicel, gellan, carrageenan) and calcium HMB or other HMB sources in water: minerals (eg , Potassium citrate, dipotassium phosphate, sodium citrate, etc.) under heating and stirring. The resulting CHO-MIN slurry is maintained for 10 minutes under continuous heating and stirring, followed by additional minerals (eg, potassium chloride, magnesium carbonate, potassium iodide, etc.), carbohydrates (eg, flucotooligosaccharides, sucrose, corn Add syrup). A PIW slurry is then formed by mixing the remaining proteins (eg, sodium caseinate, soy protein concentrate, etc.) into water under heating and stirring.

  The resulting slurry is then mixed with heating and stirring to adjust the pH to the desired range, typically 6.6-7.0, and then subject the composition to high temperature short time (HTST) processing. In the meantime, the composition is heat treated, emulsified, homogenized and then cooled. Water soluble vitamins and ascorbic acid are added, and if necessary, the pH is adjusted again to the desired range, flavoring agents are added, and water is added to obtain the desired total solids level. The composition is then packaged aseptically to obtain a sterile packaged nutritional emulsion, or the composition is added to a retort stable container and then subjected to retort sterilization to obtain a retort sterilized nutritional emulsion.

  The method for producing the nutritional emulsion may be performed by methods other than those described herein without departing from the spirit and scope of the present invention. Therefore, this embodiment is illustrative and not restrictive in all respects, and all changes and equivalents should be considered to be included in the description of the present disclosure.

Methods of Use The nutritional emulsions described herein provide supplemental, primary or sole nutritional sources and / or provide one or more benefits described herein to an individual Useful to do. By such a method, the emulsion is most typically once or twice daily, in one or two or more divided doses as needed to provide the desired level of nutrition. It can be administered orally in the form of a serving. For example, dosages typically range from about 100 to about 300 ml, such as from about 150 to about 250 ml, such as from about 190 ml to about 240 ml, where each dosage is from about 0.4 to about About 3.0 g, for example about 0.75 to about 2.0 g, for example about 1.5 g of calcium HMB.

  Such methods are further typically associated with the administration of such products after 1 to about 6 months, such as after about 1 to about 3 months of long-term daily use 1) Help maintain lean body mass, 2) assist strength and / or muscle strength, 3) reduce proteolysis and muscle cell damage, and 4) muscle after exercise or other trauma. And 5) are directed to bring the individual one or more of reducing muscle protein degradation after exercise.

  Such methods also include: 1) maintaining and supporting lean body mass in older people with sarcopenia, 2) to support an active and independent lifestyle in individuals, especially older people 1) providing nutrition, 3) assisting muscle strength recovery, 4) helping muscles to rebuild and restore strength, and 5) improving strength, eg muscle strength and mobility. It is useful to achieve the above.

Data The following nutritional emulsions A, B and C are formulated, aseptically packaged and evaluated for flavor. The nutritional emulsions are similar in composition and are produced by similar methods. Each sample is an oil-in-water emulsion containing fat, protein, carbohydrates, vitamins and minerals, containing 1.5 g calcium HMB per 240 ml emulsion. However, the samples differ in that each contains a different ratio of soluble protein to total protein weight. The samples are evaluated 6 months after formulation and packaging using standard sensory methods (5-point rating scale). The results are summarized below.

  The data shows a surprising correlation between the soluble protein fraction (eg Na caseinate) and the development of bitter and soap-like sensory properties over time. The data also surprisingly suggests that the occurrence of such undesirable sensory characteristics can be minimized or reduced by formulating the majority of the total protein as soluble protein.

  The following examples illustrate certain embodiments and / or features of the nutritional emulsions of the present disclosure. The examples are described solely for purposes of illustration and are not to be construed as limiting the present disclosure, and numerous modifications thereof are possible without departing from the spirit and scope of the disclosure. All exemplified amounts are weight ratios to the total weight of the composition unless otherwise indicated.

  Exemplified compositions are storage stable nutritional emulsions produced by the production methods described herein, and each exemplified composition is an aseptically processed embodiment unless otherwise indicated. And retort packaging embodiments. These compositions are aqueous oil-in-water emulsions packaged in 240 ml plastic containers, physically at storage temperatures in the range of 1-25 ° C. for 12-18 months after formulation / packaging. Stay stable. Similarly, the packaging emulsion remains stable at pH over time and does not generate an excessively bitter flavor or aftertaste during storage.

[Examples 1 to 4]
Examples 1-4 illustrate the nutritional emulsions of the present disclosure, the components of which are shown in the table below. Unless otherwise indicated, all ingredient amounts are given as kilograms per 1000 kilograms of product batch.

[Examples 5 to 8]
Examples 5-8 illustrate the nutritional emulsions of the present disclosure, the components of which are shown in the table below. Unless otherwise indicated, all ingredient amounts are given as kilograms per 1000 kilograms of product batch.

[Examples 9 to 12]
Examples 9-12 illustrate the nutritional emulsions of the present disclosure, the components of which are shown in the table below. Unless otherwise indicated, all ingredient amounts are given as kilograms per 1000 kilograms of product batch.

[Examples 13 to 16]
Examples 13-16 illustrate the nutritional emulsions of the present disclosure, the components of which are shown in the table below. Unless otherwise indicated, all ingredient amounts are given as kilograms per 1000 kilograms of product batch.

[Examples 17 to 20]
Examples 17-20 illustrate the nutritional emulsions of the present disclosure, the components of which are shown in the table below. Unless otherwise indicated, all ingredient amounts are given as kilograms per 1000 kilograms of product batch.

Claims (13)

A nutritional emulsion comprising fat, carbohydrate, protein and calcium beta-hydroxy-beta-methylbutyrate (calcium HMB), wherein the soluble protein represents 50% to 100% by weight of the total protein in the emulsion ; . 1% to 8% by weight of calcium beta - hydroxy - beta - see including methyl butyrate, soluble proteins are sodium caseinate, whey protein concentrate and selected from the group consisting of, pH 5.5 The nutritional emulsion, which is 7.3 .   The nutritional emulsion of claim 1, wherein the soluble protein comprises 55% to 100% by weight of the total protein and comprises a phosphoserine-containing protein having at least 100 mmol of phosphoserine per kilogram of phosphoserine-containing protein.   The nutritional emulsion according to claim 2, wherein the soluble protein represents 60% to 85% by weight of the total protein. The emulsion is 0 . The nutritional emulsion of claim 1 comprising 2 to 3 wt% calcium beta-hydroxy-beta-methylbutyrate (calcium HMB).   The nutritional emulsion of claim 1, wherein the emulsion is packaged in a closed container and is storage stable at a temperature of 18 ° C. to 24 ° C. for at least 3 months. Fat, carbohydrate, protein and calcium beta - hydroxy - beta - a nutrient emulsion containing methylbutyrate (calcium HMB), soluble protein constitute 5 0 wt% to 100 wt% of the total protein, the emulsion is, Having a weight ratio of soluble protein to calcium HMB of 3 : 1 to 12: 1, wherein the soluble protein is selected from the group consisting of sodium caseinate, whey protein concentrate and combinations thereof, pH 5.5-7 .3, the nutritional emulsion.   The nutritional emulsion according to claim 6, wherein the soluble protein comprises 55% to 100% by weight of the total protein and comprises a phosphoserine-containing protein having at least 100 mmol of phosphoserine per kilogram of phosphoserine-containing protein.   The nutritional emulsion according to claim 6, wherein the soluble protein represents 60% to 85% by weight of the total protein.   The nutritional emulsion of claim 6, wherein the soluble protein comprises sodium caseinate. The concentration of soluble protein is 0 . The nutritional emulsion of Claim 6 which is 5 weight% -26 weight%. The emulsion is 0 . 3% by weight to 1 . The nutritional emulsion of claim 6 comprising 5% by weight of calcium HMB. The nutritional emulsion according to claim 6, wherein the weight ratio of soluble protein to calcium HMB is 4 : 1 to 12: 1.   The nutritional emulsion according to claim 6, wherein the emulsion is packaged in a closed container and is storage-stable at a temperature of 18C to 24C for at least 3 months.