JP5989226B2 - Gel-like composition for skin - Google Patents
Gel-like composition for skin Download PDFInfo
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- JP5989226B2 JP5989226B2 JP2015502844A JP2015502844A JP5989226B2 JP 5989226 B2 JP5989226 B2 JP 5989226B2 JP 2015502844 A JP2015502844 A JP 2015502844A JP 2015502844 A JP2015502844 A JP 2015502844A JP 5989226 B2 JP5989226 B2 JP 5989226B2
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- meth
- component
- gel
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- 150000001768 cations Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 229940107200 chondroitin sulfates Drugs 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- HRUVKSKSDDVGMC-JDYVBSGKSA-L disodium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;sulfate Chemical compound [Na+].[Na+].OS([O-])(=O)=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] HRUVKSKSDDVGMC-JDYVBSGKSA-L 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 1
- 229940025902 konjac mannan Drugs 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940074358 magnesium ascorbate Drugs 0.000 description 1
- OVGXLJDWSLQDRT-UHFFFAOYSA-L magnesium lactate Chemical compound [Mg+2].CC(O)C([O-])=O.CC(O)C([O-])=O OVGXLJDWSLQDRT-UHFFFAOYSA-L 0.000 description 1
- 239000000626 magnesium lactate Substances 0.000 description 1
- 229960004658 magnesium lactate Drugs 0.000 description 1
- 235000015229 magnesium lactate Nutrition 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- AIOKQVJVNPDJKA-ZZMNMWMASA-L magnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-olate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] AIOKQVJVNPDJKA-ZZMNMWMASA-L 0.000 description 1
- 125000005641 methacryl group Chemical group 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000010318 polygalacturonic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000019423 pullulan Nutrition 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- 229940048086 sodium pyrophosphate Drugs 0.000 description 1
- 229940045920 sodium pyrrolidone carboxylate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- HYRLWUFWDYFEES-UHFFFAOYSA-M sodium;2-oxopyrrolidine-1-carboxylate Chemical compound [Na+].[O-]C(=O)N1CCCC1=O HYRLWUFWDYFEES-UHFFFAOYSA-M 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 125000003696 stearoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- CXVGEDCSTKKODG-UHFFFAOYSA-N sulisobenzone Chemical compound C1=C(S(O)(=O)=O)C(OC)=CC(O)=C1C(=O)C1=CC=CC=C1 CXVGEDCSTKKODG-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 150000003700 vitamin C derivatives Chemical class 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/737—Galactomannans, e.g. guar; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
本発明は、皮膚用ジェル状組成物に関する。 The present invention relates to a gel-like composition for skin.
電解質、特に多価陽イオンが配合された組成物のジェル化は、凝集を引き起こし易くなり充分な増粘効果が得られ難いばかりでなく、電解質に由来する析出物が生じやすくなることから、ジェル化すること自体が非常に困難である。このように電解質が含まれる組成物をジェル化させることは、技術的な課題が非常に多い。 Gelling of an electrolyte, particularly a composition containing a polyvalent cation, is not only easy to cause agglomeration and it is difficult to obtain a sufficient thickening effect, but also a precipitate derived from the electrolyte tends to be generated. It is very difficult to make it. The gelation of the composition containing the electrolyte in this way has many technical problems.
電解質の塩の影響を低減するために、増粘剤を高配合することも考えられるが、このような試みでは、製剤安定性に劣るだけでなく、塗布時の延展性に劣り、ムラ付きするために、べたつき感などの使用感が悪化するといった問題もある。 In order to reduce the influence of electrolyte salt, it is conceivable to add a thickening agent in a high amount. However, in such an attempt, not only the stability of the preparation is inferior, but also the spreadability during application is inferior and uneven. For this reason, there is a problem that the feeling of use such as stickiness is deteriorated.
そこで、電解質配合系の安定化に適していると言われるノニオン性多糖系化合物を用いた試みもなされている。具体的には、ビタミンＣ誘導体、ガム質およびセルロース系高分子を含有する化粧料（例えば、特許文献１を参照）、化粧品用活性剤、電解質およびセチルヒドロキシエチルセルロースを含有するゲル化局所用組成物（例えば、特許文献２を参照）、キサンタンガム又はカッパカラギーナン、ローカストビーンガム、ヒアルロン酸若しくはその塩又はヒドロキシエチルセルロース、多価金属塩を含有する皮膚外用剤（例えば、特許文献３を参照）、メチルセルロース、乳化剤、液状油剤および電解質を含有する水中油型気泡含有化粧料（例えば、特許文献４を参照）などが提案されている。 Therefore, an attempt has been made to use a nonionic polysaccharide compound which is said to be suitable for stabilizing the electrolyte blending system. Specifically, a cosmetic preparation containing a vitamin C derivative, a gum and a cellulosic polymer (see, for example, Patent Document 1), a cosmetic active agent, an electrolyte, and a gelled topical composition containing cetyl hydroxyethyl cellulose (For example, refer to Patent Document 2), xanthan gum or kappa carrageenan, locust bean gum, hyaluronic acid or a salt thereof, or hydroxyethyl cellulose, a topical skin preparation containing a polyvalent metal salt (for example, refer to Patent Document 3), methyl cellulose, An oil-in-water type bubble-containing cosmetic containing an emulsifier, a liquid oil agent and an electrolyte (for example, see Patent Document 4) has been proposed.
しかしながら、これら試みに拠って、ある程度安定性を高めることはできるものの、ノニオン性多糖増粘剤は、それ自体の増粘効果が弱く、ジェル化させるためには高配合しなければならず、ヌルつきやベタつきなど使用感に悪影響を及ぼすといった問題がある。 However, although these attempts can improve the stability to some extent, the nonionic polysaccharide thickener has a weakening effect on its own and has to be highly blended to make it into a gel. There are problems such as stickiness and stickiness that adversely affect the feeling of use.
本発明は、前記従来技術に鑑みてなされたものであり、電解質が存在する環境下であっても容易にジェル化することができ、そのジェル化製剤の安定性に優れた効果を発揮するとともに、使用時において、塗布時の延展性や使用感にも優れる皮膚用ジェル状組成物を提供することを課題とする。 The present invention has been made in view of the prior art, and can be easily gelled even in an environment where an electrolyte is present, and exhibits an excellent effect on the stability of the gelled preparation. An object of the present invention is to provide a gel-like composition for skin that is excellent in spreadability and usability during application.
即ち、本発明は、
〔１〕（Ａ）電解質、（Ｂ）ノニオン性多糖系化合物、並びに（Ｃ）下記（Ｃ１）〜（Ｃ４）を必須のモノマー成分として形成されるクロスポリマーを含有する皮膚用ジェル状組成物、
（Ｃ１）（メタ）アクリルアミドメチルプロパンスルホン酸塩、
（Ｃ２）ジメチル（メタ）アクリルアミド、
（Ｃ３）（メタ）アクリル酸アルキル、
（Ｃ４）（メタ）アクリル酸ポリオキシエチレンアルキルエーテル
〔２〕前記（Ｂ）成分が、ローカストビーンガム、タラガム、グアーガムおよびヒドロキシプロピルグアーガムから選ばれる少なくとも１種である前記〔１〕に記載の皮膚用ジェル状組成物、
〔３〕前記（Ｃ）成分が、（メタ）アクリルアミドメチルプロパンスルホン酸アンモニウム／ジメチル（メタ）アクリルアミド／（メタ）アクリル酸ラウリル／（メタ）アクリル酸ポリオキシエチレンラウリルエーテルクロスポリマーである前記〔１〕又は〔２〕に記載の皮膚用ジェル状組成物、
〔４〕前記（Ｂ）成分の含有量が０．２〜１質量％であり、前記（Ｃ）成分の含有量が０．１〜２質量％である前記〔１〕〜〔３〕の何れかに記載の皮膚用ジェル状組成物、
〔５〕更に、（Ｄ）ペクチンを含有してなる前記〔１〕〜〔４〕の何れかに記載の皮膚用ジェル状組成物、並びに
〔６〕前記（Ｄ）成分の含有量が０．１〜１．５質量％であり、（Ｂ）成分と（Ｄ）成分の合計量に対する（Ｄ）成分の含有量比（Ｄ／Ｂ＋Ｄ）が０．１〜０．８の範囲である前記〔５〕に記載の皮膚用ジェル状組成物
に関する。
That is, the present invention
[1] A gel-like composition for skin containing (A) an electrolyte, (B) a nonionic polysaccharide compound, and (C) a cross polymer formed using the following (C1) to (C4) as essential monomer components,
(C1) (meth) acrylamidomethylpropane sulfonate,
(C2) dimethyl (meth) acrylamide,
(C3) alkyl (meth) acrylate,
(C4) (Meth) acrylic acid polyoxyethylene alkyl ether [2] The skin according to [1], wherein the component (B) is at least one selected from locust bean gum, tara gum, guar gum and hydroxypropyl guar gum Gel-like composition for
[3] The component (C) is an ammonium (meth) acrylamide methylpropanesulfonate / dimethyl (meth) acrylamide / lauryl (meth) acrylate / polyoxyethylene lauryl ether crosspolymer (meth) acrylate [1] ] Or a gel-like composition for skin according to [2],
[4] Any of [1] to [3], wherein the content of the component (B) is 0.2 to 1% by mass and the content of the component (C) is 0.1 to 2% by mass. A gel-like composition for skin according to claim 1,
[5] Furthermore, the gel-like composition for skin according to any one of [1] to [4], further comprising (D) pectin, and [6] the content of the component (D) is 0. The content ratio (D / B + D) of the component (D) to the total amount of the component (B) and the component (D) is in the range of 0.1 to 0.8. 5] The gel-like composition for skin according to [5].
本発明の皮膚用ジェル状組成物は、例え、電解質が存在する環境下であっても容易にジェル化することができ、その調製したジェル状組成物は、格段に優れた安定性を有するという効果を奏する。また、本発明の皮膚用ジェル状組成物は、使用時において、塗布時の延展性に優れ、均一に延び広がるとともに、ヌルつきやベタつきがなく、使用感に優れた効果を発揮する。 The gel-like composition for skin of the present invention can be easily gelled even in an environment where an electrolyte is present, and the prepared gel-like composition has remarkably excellent stability. There is an effect. Moreover, the gel-like composition for skin of the present invention has excellent spreadability at the time of application, spreads and spreads evenly during use, has no nulliness or stickiness, and exhibits an excellent usability.
本発明の皮膚用ジェル状組成物は、（Ａ）電解質、（Ｂ）ノニオン性多糖系化合物、並びに（Ｃ）（Ｃ１）（メタ）アクリルアミドメチルプロパンスルホン酸塩、（Ｃ２）ジメチル（メタ）アクリルアミド、（Ｃ３）（メタ）アクリル酸アルキル、（Ｃ４）（メタ）アクリル酸ポリオキシエチレンアルキルエーテルを必須のモノマー成分として形成されるクロスポリマーを含有する。
The gel-like composition for skin of the present invention comprises (A) an electrolyte, (B) a nonionic polysaccharide compound, (C) (C1) (meth) acrylamide methylpropanesulfonate, and (C2) dimethyl (meth) acrylamide. , (C3) (meth) acrylic acid alkyl and (C4) (meth) acrylic acid polyoxyethylene alkyl ether are used as the essential monomer components.
（Ａ）成分の電解質は、通常、美白効果、保湿効果、消炎効果、収斂効果、紫外線吸収効果、制汗効果などを期待して配合されるものである。本発明においては、通常、化粧料原料として使用できるものであれば特に限定されず、目的に応じて適宜配合すればよい。 The electrolyte of the component (A) is usually blended in anticipation of a whitening effect, a moisturizing effect, an anti-inflammatory effect, an astringent effect, an ultraviolet absorption effect, an antiperspirant effect, and the like. In the present invention, it is not particularly limited as long as it can be used as a cosmetic raw material, and may be appropriately blended depending on the purpose.
用いられる（Ａ）成分としては、例えば、有機酸およびその塩、無機酸およびその塩が挙げられる。具体的には、無機カルシウム塩、無機カリウム塩、無機ナトリウム塩、無機マグネシウム塩などの無機塩；乳酸ナトリウム、乳酸マグネシウム、乳酸カルシウムなどの乳酸塩；コンドロイチン硫酸ナトリウム、ステアロイルコンドロイチン硫酸ナトリウムなどのコンドロイチン硫酸塩；デルマタン硫酸ナトリウムなどのデルマタン硫酸塩；リン酸カリウム、リン酸ナトリウム、ピロリン酸ナトリウムなどのリン酸塩；グリチルリチン酸ジカリウム塩などのグリチルリチン酸塩；アスコルビン酸リン酸エステルマグネシウム、アスコルビン酸リン酸エステルナトリウム、アスコルビン酸ナトリウム、Ｌ−アスコルビン酸硫酸エステル二ナトリウムなどのアスコルビン酸塩；ピロリドンカルボン酸ナトリウム、ピロリドンカルボン酸亜鉛などのピロリドンカルボン酸塩；グリシン、トレオニン、アラニン、チロシン、バリン、ロイシン、アルギニン、プロリン、アスパラギン酸、グルタミン酸、セリンなどのアミノ酸およびこれらの誘導体；２−ヒドロキシ−４−メトキシベンゾフェノン−５−スルホン酸およびそのナトリウム塩などの紫外線吸収剤；クロルヒドロキシアルミニウム、パラフェノールスルホン酸亜鉛などの制汗剤などが挙げられる。これら（Ａ）成分は、１種を単独で用いても良く、２種以上を適宜組み合わせて用いても良い。 Examples of the component (A) used include organic acids and salts thereof, inorganic acids and salts thereof. Specifically, inorganic salts such as inorganic calcium salts, inorganic potassium salts, inorganic sodium salts, and inorganic magnesium salts; lactates such as sodium lactate, magnesium lactate, and calcium lactate; chondroitin sulfates such as sodium chondroitin sulfate and sodium stearoyl chondroitin sulfate Dermatan sulfate such as sodium dermatan sulfate; phosphates such as potassium phosphate, sodium phosphate and sodium pyrophosphate; glycyrrhizinate such as dipotassium glycyrrhizinate; magnesium ascorbate phosphate, phosphate ester of ascorbate Ascorbates such as sodium, sodium ascorbate, and disodium L-ascorbate sulfate; sodium pyrrolidone carboxylate, Amino acids such as glycine, threonine, alanine, tyrosine, valine, leucine, arginine, proline, aspartic acid, glutamic acid, serine and derivatives thereof; 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid and its UV absorbers such as sodium salts; antiperspirants such as chlorohydroxyaluminum and zinc paraphenolsulfonate. These (A) components may be used individually by 1 type, and may be used in combination of 2 or more types as appropriate.
（Ａ）成分の含有量は、特に限定されないが、通常、望む効果を付与する観点から、組成物中、０．０１質量％以上が好ましく、より好ましくは０．０５質量％以上である。また、製剤安定性の観点から、１５質量％以下が好ましく、より好ましくは１０質量％以下である。これらの観点から、（Ａ）成分の含有量は、好ましくは０．０１〜１５質量％、より好ましくは０．０５〜１０質量％である。 Although content of (A) component is not specifically limited, 0.01 mass% or more is preferable in a composition from a viewpoint of providing the desired effect normally, More preferably, it is 0.05 mass% or more. Moreover, from a viewpoint of formulation stability, 15 mass% or less is preferable, More preferably, it is 10 mass% or less. From these viewpoints, the content of the component (A) is preferably 0.01 to 15% by mass, more preferably 0.05 to 10% by mass.
（Ｂ）成分のノニオン性多糖系化合物としては、例えば、ノニオン性の多糖および／又はその誘導体が挙げられる。具体的には、例えば、グルコース、ガラクトース、マンノース、アラビノース、キシロースなどの単糖類の１種又は２種以上で構成される多糖、並びにこれら多糖を、例えば、アルキル基、特にヒドロキシアルキル基などで変性させた変性多糖などが挙げられる。 Examples of the nonionic polysaccharide compound (B) include nonionic polysaccharides and / or derivatives thereof. Specifically, for example, polysaccharides composed of one or more monosaccharides such as glucose, galactose, mannose, arabinose, and xylose, and these polysaccharides are modified with, for example, alkyl groups, particularly hydroxyalkyl groups. Modified polysaccharides and the like.
具体的な（Ｂ）成分としては、例えば、デキストラン、プルラン、ローカストビーンガム、アラビノガラクタン、タラガム、グアーガム、タマリンド種子ガム、コンニャクマンナン、ヒドロキシプロピルグアーガムなどが挙げられる。これら（Ｂ）成分は、１種を単独で用いても良く、２種以上を適宜組み合わせて用いても良い。好適な（Ｂ）成分としては、容易にジェル化できる観点、並びに製剤安定性の観点から、ローカストビーンガム、タラガム、グアーガム、ヒドロキシプロピルグアーガムを用いることが好ましい。 Specific examples of the component (B) include dextran, pullulan, locust bean gum, arabinogalactan, tara gum, guar gum, tamarind seed gum, konjac mannan, and hydroxypropyl guar gum. These (B) components may be used individually by 1 type, and may be used in combination of 2 or more types as appropriate. As a suitable component (B), it is preferable to use locust bean gum, tara gum, guar gum, or hydroxypropyl guar gum from the viewpoint of easy gelation and the stability of the preparation.
尚、（Ｂ）成分は、市販品を用いることもできる。ローカストビーンガムの市販品としては、例えば、イナゲル ローカストビーンガムＣＳ（商品名，伊那食品工業社製）、メイプロ−ＬＢＧ フレール Ｍ−１７５、メイプロ−ＬＢＧ フレール Ｍ−２００、メイプロ−ＬＢＧ ラック（商品名，Ｄａｎｉｓｃｏ社製）、ゲニューガム ＲＬ−２００−Ｊ（商品名，ＣＰ Ｋｅｌｃｏ社製）などが挙げられる。 In addition, a commercial item can also be used for (B) component. As a commercially available product of locust bean gum, for example, Inagel locust bean gum CS (trade name, manufactured by Ina Food Industry Co., Ltd.), Meipro-LBG Fler M-175, Meipro-LBG Fler M-200, Meipro-LBG Rack (trade name) , Danisco Co.), Genu gum RL-200-J (trade name, CP Kelco).
タラガムの市販品としては、例えば、スピノガム（商品名，三晶社製）、ビストップＤ−２１０１（商品名，三栄源エフ・エフ・アイ社製）などが挙げられる。 Examples of commercially available tara gum include spino gum (trade name, manufactured by Sanki Co., Ltd.), Bistop D-2101 (trade name, manufactured by Saneigen FFI Co., Ltd.), and the like.
グアーガムの市販品としては、例えば、イナゲル グアーガムＣＳ（商品名，伊那食品工業社製）、ＭＥＹＰＲＯ−ＧＵＡＲ（商品名，Ｄａｎｉｓｃｏ社製）などが挙げられる。 Examples of commercially available products of guar gum include Inagel Guar Gum CS (trade name, manufactured by Ina Food Industry Co., Ltd.) and MEYPRO-GUAR (trade name, manufactured by Danisco).
ヒドロキシプロピルグアーガムの市販品としては、例えば、ＪＡＧＵＡＲ ＨＰ−８（商品名，三晶社製）などが挙げられる。 Examples of commercially available hydroxypropyl guar gum include JAGUAR HP-8 (trade name, manufactured by Sankisha).
（Ｂ）成分の含有量は、特に限定されないが、通常、容易にジェル化でき、優れた製剤安定性を付与する観点、並びに塗布時の延展性を高め、均一に延び広げる観点から、組成物中、０．１質量％以上が好ましく、より好ましくは０．２質量％以上である。また、使用感の観点から、３質量％以下が好ましく、より好ましくは１質量％以下である。これらの観点から、（Ｂ）成分の含有量は、好ましくは０．１〜３質量％、より好ましくは０．２〜１質量％である。 The content of the component (B) is not particularly limited, but it is usually a composition that can be easily gelled, imparts excellent formulation stability, and enhances the spreadability at the time of application and spreads uniformly. Among them, 0.1% by mass or more is preferable, and more preferably 0.2% by mass or more. Moreover, from a viewpoint of usability | use_condition, 3 mass% or less is preferable, More preferably, it is 1 mass% or less. From these viewpoints, the content of the component (B) is preferably 0.1 to 3% by mass, more preferably 0.2 to 1% by mass.
本発明の（Ｃ）成分は、下記（Ｃ１）〜（Ｃ４）を必須のモノマー成分として形成されるクロスポリマーである。尚、本明細書において、「（メタ）アクリル」とは、「メタクリル」および「アクリル」の双方又は一方を意味する。
（Ｃ１）（メタ）アクリルアミドメチルプロパンスルホン酸塩、
（Ｃ２）ジメチル（メタ）アクリルアミド、
（Ｃ３）（メタ）アクリル酸アルキル、
（Ｃ４）（メタ）アクリル酸ポリオキシエチレンアルキルエーテルThe component (C) of the present invention is a cross polymer formed using the following (C1) to (C4) as essential monomer components. In the present specification, “(meth) acryl” means both or one of “methacryl” and “acryl”.
(C1) (meth) acrylamidomethylpropane sulfonate,
(C2) dimethyl (meth) acrylamide,
(C3) alkyl (meth) acrylate,
(C4) (Meth) acrylic acid polyoxyethylene alkyl ether
必須モノマー成分（Ｃ１）である（メタ）アクリルアミドメチルプロパンスルホン酸塩の塩としては、特に限定されないが、例えば、ナトリウム塩、カリウム塩、アンモニウム塩などが挙げられる。本発明においては、容易にジェル化できる観点から、（メタ）アクリルアミドメチルプロパンスルホン酸のアンモニウム塩を用いることが好ましい。 Although it does not specifically limit as a salt of the (meth) acrylamide methyl propane sulfonate which is an essential monomer component (C1), For example, a sodium salt, potassium salt, ammonium salt etc. are mentioned. In the present invention, it is preferable to use an ammonium salt of (meth) acrylamidomethylpropanesulfonic acid from the viewpoint of easy gelation.
必須モノマー成分（Ｃ３）である（メタ）アクリル酸アルキルのアルキル鎖長は、特に限定されないが、例えば、炭素数６〜２２のアルキル基を例示することができる。本発明においては、容易にジェル化できる観点から、炭素数１０〜１６のアルキル基を有する（メタ）アクリル酸アルキルを用いることが好ましく、中でも、炭素数１２のアルキル基を有する（メタ）アクリル酸ラウリルを用いることがより好ましい。 Although the alkyl chain length of the alkyl (meth) acrylate which is an essential monomer component (C3) is not specifically limited, For example, a C6-C22 alkyl group can be illustrated. In the present invention, from the viewpoint of easy gelation, it is preferable to use an alkyl (meth) acrylate having an alkyl group having 10 to 16 carbon atoms, and among them, (meth) acrylic acid having an alkyl group having 12 carbon atoms. More preferably, lauryl is used.
必須モノマー成分（Ｃ４）である（メタ）アクリル酸ポリオキシエチレンアルキルエーテルのアルキル鎖長は、特に限定されないが、例えば、炭素数６〜２２のアルキル基を例示することができる。本発明においては、容易にジェル化できる観点から、炭素数１０〜１６のアルキル基を有する（メタ）アクリル酸ポリオキシエチレンアルキルエーテルを用いることが好ましく、中でも、炭素数１２のアルキル基を有する（メタ）アクリル酸ポリオキシエチレンラウリルエーテルを用いることがより好ましい。尚、酸化エチレンの平均付加モル数は、特に限定されないが、１〜３０であることが好ましい。 The alkyl chain length of the (meth) acrylic acid polyoxyethylene alkyl ether which is the essential monomer component (C4) is not particularly limited, and examples thereof include an alkyl group having 6 to 22 carbon atoms. In the present invention, it is preferable to use (meth) acrylic acid polyoxyethylene alkyl ether having an alkyl group having 10 to 16 carbon atoms from the viewpoint that gelation can be easily performed, and among them, an alkyl group having 12 carbon atoms ( It is more preferable to use (meth) acrylic acid polyoxyethylene lauryl ether. The average added mole number of ethylene oxide is not particularly limited, but is preferably 1-30.
具体的な（Ｃ）成分としては、例えば、ＩＮＣＩ名（Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｃｏｓｍｅｔｉｃ Ｉｎｇｒｅｄｉｅｎｔ Ｄｉｃｔｉｏｎａｒｙ ａｎｄ Ｈａｎｄｂｏｏｋ，第１４版，第２巻，ＣＴＦＡ，２０１２年，ｐ．２４８１）：ＰＯＬＹＡＣＲＹＬＡＴＥ ＣＲＯＳＳＰＯＬＹＭＥＲ−６（ポリアクリレートクロスポリマー−６）で表記される、（メタ）アクリルアミドメチルプロパンスルホン酸アンモニウム／ジメチル（メタ）アクリルアミド／（メタ）アクリル酸ラウリル／（メタ）アクリル酸ポリオキシエチレン（４）ラウリルエーテルクロスポリマーなどが挙げられる。 Specific examples of the component (C) include, for example, the INCI name (International Cosmetic Ingredient Dictionary and Handbook, 14th edition, Volume 2, CTFA, 2012, p.2481): POLYACRYLATE CROSSPOLYMER-6 (polyacrylate crosspolymer- (Meth) acrylamidomethylpropanesulfonate ammonium / dimethyl (meth) acrylamide / lauryl (meth) acrylate / polyoxyethylene (meth) acrylate (4) lauryl ether crosspolymer represented by 6).
尚、（Ｃ）成分は、市販品を用いることもできる。ＰＯＬＹＡＣＲＹＬＡＴＥ ＣＲＯＳＳＰＯＬＹＭＥＲ−６の市販品としては、例えば、ＳＥＰＩＭＡＸ ＺＥＮ（商品名，ＳＥＰＰＩＣ社製）などが挙げられる。 In addition, a commercial item can also be used for (C) component. Examples of commercially available products of POLYACRYLATE CROSSPOLYMER-6 include SEPIMAX ZEN (trade name, manufactured by SEPPIC).
（Ｃ）成分の含有量は、特に限定されないが、通常、容易にジェル化でき、優れた製剤安定性を付与する観点、並びに塗布時の延展性を高め、均一に延び広げる観点から、組成物中、０．０５質量％以上が好ましく、より好ましくは０．１質量％以上である。また、使用感の観点から、５質量％以下が好ましく、より好ましくは２質量％以下である。これらの観点から、（Ｃ）成分の含有量は、好ましくは０．０５〜５質量％、より好ましくは０．１〜２質量％である。 Although the content of the component (C) is not particularly limited, it is usually a composition that can be easily gelled, imparts excellent formulation stability, and enhances the spreadability during coating and spreads uniformly. In the content, 0.05% by mass or more is preferable, and more preferably 0.1% by mass or more. Moreover, from a viewpoint of a usability | use_condition, 5 mass% or less is preferable, More preferably, it is 2 mass% or less. From these viewpoints, the content of the component (C) is preferably 0.05 to 5% by mass, more preferably 0.1 to 2% by mass.
本発明の皮膚用ジェル状組成物には、ヌルつきやベタつきを更に抑えて使用感をより一層高める観点、並びに製剤安定性をも高める観点から、（Ｄ）ペクチンを含有させることができる。 The gel-like composition for skin of the present invention may contain (D) pectin from the viewpoint of further suppressing the stickiness and stickiness and further enhancing the feeling of use and also enhancing the stability of the preparation.
（Ｄ）成分のペクチンとは、柑橘類、リンゴ、ナシ、ブドウなどの果実やニンジン、豆類などの野菜に含まれるものであり、果実や野菜から抽出することによって得られる成分である。主成分はガラクツロン酸からなり、ガラクツロン酸が鎖状にα−１，４グリコシド結合したポリガラクツロン酸のカルボキシル基が部分的にメチルエステル化されている構造を有する。ペクチンには、抽出工程違いによるメチルエステル化度（％）（以下、ＤＥ値（％）と略す）の異なるペクチン、並びに、酸又はアルカリを用いて脱メチルエステル化し、ＤＥ値（％）を制御することにより得られるペクチンなどがある。尚、本発明で言うＤＥ値（％）とは、総ガラクツロン酸数に対するメチルエステル化されたガラクツロン酸数の割合を示す。 (D) Component pectin is contained in fruits such as citrus fruits, apples, pears and grapes, and vegetables such as carrots and beans, and is a component obtained by extraction from fruits and vegetables. The main component is composed of galacturonic acid, and has a structure in which the carboxyl group of polygalacturonic acid in which galacturonic acid is linked in a chain form with α-1,4 glycoside is partially methyl esterified. Pectin has different degrees of methyl esterification (%) (hereinafter abbreviated as DE value (%)) due to different extraction processes, and demethylesterified with acid or alkali to control DE value (%). There are pectin obtained by doing. In addition, DE value (%) said by this invention shows the ratio of the number of galacturonic acids methylated to the total number of galacturonic acids.
用いられるペクチンのＤＥ値（％）は、所望の効果が十分に付与されるのであれば特に限定されないが、ヌルつきやベタつきを更に抑えて使用感をより一層高める観点、並びに製剤安定性を高める観点から、ＤＥ値（％）が２０〜７０％のペクチンを用いることが好ましい。本発明においては、ＤＥ値（％）が２０〜７０％のペクチンを単独で用いても良く、ＤＥ値（％）の異なるペクチンの２種以上を適宜組み合わせて用いても良い。 The DE value (%) of the pectin used is not particularly limited as long as the desired effect is sufficiently imparted. However, the viewpoint of further enhancing the feeling of use by further suppressing the stickiness and stickiness and the stability of the preparation are improved. From the viewpoint, it is preferable to use pectin having a DE value (%) of 20 to 70%. In the present invention, pectin having a DE value (%) of 20 to 70% may be used alone, or two or more pectins having different DE values (%) may be used in appropriate combination.
尚、（Ｄ）成分は、市販品を用いることもできる。ＤＥ値（％）が２０〜７０％のペクチンの市販品としては、例えば、ネオソフト Ｐ−３（商品名，太陽化学社製）、ＧＥＮＵ ＰＥＣＴＩＮ ＬＭ−１０６ＡＳ−ＹＡ−Ｊ、ＬＭ−１０４ＡＳ−ＢＧ−Ｊ、ＬＭ−１０４ＡＳ−ＦＳ−Ｊ、ＬＭ−１０４ＡＳ−Ｊ、Ｘ−２１１−０４、ＬＭ−８４ＡＳ、ＬＭ−１０２ＡＳ−Ｊ、ＬＭ−１０１ＡＳ−Ｊ、ＬＭ−１０１ＡＳ−ＪＳ−Ｊ、ＬＭ−１０５ＡＳ−Ｊ、ＢＥＴＡ ＢＩ−Ｊ、ＪＭ−１５０−Ｊ、ＪＭＪ−Ｊ、ＤＦ−Ｚ−Ｊ（商品名，何れもコペンハーゲン ペクチンファクトリー社製）などが挙げられる。 In addition, a commercial item can also be used for (D) component. Examples of commercially available pectin products having a DE value (%) of 20 to 70% include Neosoft P-3 (trade name, manufactured by Taiyo Chemical Co., Ltd.), GENU PECTIN LM-106AS-YA-J, and LM-104AS-BG. -J, LM-104AS-FS-J, LM-104AS-J, X-211-04, LM-84AS, LM-102AS-J, LM-101AS-J, LM-101AS-JS-J, LM-105AS -J, BETA BI-J, JM-150-J, JMJ-J, DF-Z-J (trade names, all manufactured by Copenhagen Pectin Factory) and the like.
（Ｄ）成分の含有量は、特に限定されないが、通常、ヌルつきやベタつきを更に抑えて使用感をより一層高める観点、並びに製剤安定性を高める観点から、組成物中、０．０５質量％以上が好ましく、より好ましくは０．１質量％以上である。また、使用感の観点から、３質量％以下が好ましく、より好ましくは１．５質量％以下である。これらの観点から、（Ｄ）成分の含有量は、好ましくは０．０５〜３質量％、より好ましくは０．１〜１．５質量％である。 The content of the component (D) is not particularly limited, but it is generally 0.05% by mass in the composition from the viewpoint of further enhancing the feeling of use by further suppressing the stickiness and stickiness, and further enhancing the stability of the preparation. The above is preferable, and more preferably 0.1% by mass or more. Moreover, from a viewpoint of usability, 3 mass% or less is preferable, More preferably, it is 1.5 mass% or less. From these viewpoints, the content of the component (D) is preferably 0.05 to 3% by mass, more preferably 0.1 to 1.5% by mass.
本発明においては、上記した（Ｄ）成分を更に含有させることで、（Ｂ）成分の含有量を減らすことが可能となり、ヌルつきやベタつきを低減させて、より一層使用感を高めることができることも大きな特徴の一つでもある。 In the present invention, it is possible to reduce the content of the component (B) by further containing the component (D) described above, to reduce the stickiness and stickiness, and to further improve the feeling of use. Is also one of the major features.
このような特徴を十分に発揮させるためには、上記した（Ｂ）成分の含有量と（Ｄ）成分の含有量とを、（Ｂ）成分と（Ｄ）成分の合計量に対する（Ｄ）成分の含有量比（Ｄ／Ｂ＋Ｄ）として、０．０５〜１の範囲で調製することが好ましく、０．１〜０．８の範囲で調製することがより好ましい。 In order to sufficiently exhibit such characteristics, the content of the component (B) and the content of the component (D) are changed from the content of the component (B) and the component (D) to the total amount of the component (D). The content ratio (D / B + D) is preferably in the range of 0.05 to 1, and more preferably in the range of 0.1 to 0.8.
本発明の皮膚用ジェル状組成物は、容易にジェル化できるとともに、そのジェル化製剤の安定性に優れた効果を発揮させる観点から、実質的にエタノールを含有しないことが好ましい。なお、本発明における「実質的にエタノールを含有しない」とは、「別途、エタノールを含有させることはしない」という意味であり、各配合成分中に含まれる微量のエタノールまでを除外するものではない。 The gel-like composition for skin of the present invention preferably contains substantially no ethanol from the viewpoint of easily gelling and exhibiting an effect excellent in the stability of the gelled preparation. In the present invention, “substantially does not contain ethanol” means “does not contain ethanol separately”, and does not exclude a trace amount of ethanol contained in each compounding component. .
本発明の皮膚用ジェル状組成物には、本発明の効果を損なわない範囲内であれば、上記した成分の他に通常化粧品に用いられる成分、例えば、精製水、界面活性剤、清涼剤、金属封鎖剤、防腐剤、植物抽出エキス、香料などを目的に応じて適宜配合することができる。 In the skin gel-like composition of the present invention, within the range not impairing the effects of the present invention, in addition to the above-described components, components usually used in cosmetics, for example, purified water, surfactants, cooling agents, A metal sequestering agent, preservative, plant extract, perfume and the like can be appropriately blended depending on the purpose.
本発明の皮膚用ジェル状組成物の製造方法は、特に限定されないが、例えば、公知の方法により製造することができる。具体的には、例えば、上記した成分を加えて、ディスパーミキサー、パドルミキサーなどの公知の混合装置を用いて混合する方法などが挙げられるが、本発明はこれら製造方法にのみ限定されるものではない。 Although the manufacturing method of the gel-like composition for skin of this invention is not specifically limited, For example, it can manufacture by a well-known method. Specifically, for example, a method of adding the above-described components and mixing using a known mixing apparatus such as a disper mixer, a paddle mixer, etc. can be mentioned, but the present invention is not limited to these production methods. Absent.
以下、本発明を実施例に基づいて更に詳細に説明するが、本発明はこれら実施例にのみ限定されるものではない。尚、配合量は、特記しない限り「質量％」を表す。また、評価はすべて、２３℃、湿度６０％の恒温恒湿の一定条件下で実施した。 EXAMPLES Hereinafter, although this invention is demonstrated further in detail based on an Example, this invention is not limited only to these Examples. The blending amount represents “% by mass” unless otherwise specified. Moreover, all evaluation was implemented on the constant conditions of constant temperature and humidity of 23 degreeC and 60% of humidity.
実施例および比較例では、下記の成分を用いた。
（（Ａ）電解質）
※１：パラフェノールスルホン酸亜鉛（マツモトファインケミカル社製，〔スルホ石炭酸亜鉛〕）
※２：クロルヒドロキシアルミニウム（Ｓｕｍｍｉｔ Ｒｅｓｅａｒｃｈ Ｌａｂｓ社製，〔マイクロドライ３１１５〕）
※３：ピロリドンカルボン酸亜鉛（味の素社製，〔ＡＪＩＤＥＷ ＺＮ−１００〕）
※４：乳酸カルシウム（武蔵野化学研究所社製，〔乳酸カルシウム〕）
※５：グリチルリチン酸ジカリウム（丸善製薬社製，〔グリチルリチン酸ジカリウム〕）
（（Ｂ）ノニオン性多糖増粘剤）
ローカストビーンガム（伊那食品工業社製，〔イナゲル ローカストビーンガムＣＳ〕）
タラガム（三晶社製，〔スピノガム〕）
グアーガム（伊那食品工業社製，〔イナゲル グアーガムＣＳ〕）
ヒドロキシプロピルグアーガム（三晶社製，〔ＪＡＧＵＡＲ ＨＰ−８〕）
（（Ｃ）クロスポリマー）
※６：ＰＯＬＹＡＣＲＹＬＡＴＥ ＣＲＯＳＳＰＯＬＹＭＥＲ−６（ＳＥＰＰＩＣ社製，〔ＳＥＰＩＭＡＸ ＺＥＮ〕）
（（Ｄ）ペクチン）
※７：ペクチン（コペンハーゲン ペクチンファクトリー社製，〔ＬＭ−１０４ＡＳ−Ｊ〕，ＤＥ値２７％）
※８：ペクチン（コペンハーゲン ペクチンファクトリー社製，〔ＬＭ−１０１ＡＳ−Ｊ〕，ＤＥ値３５％）
※９：ペクチン（コペンハーゲン ペクチンファクトリー社製，〔ＢＥＴＡ ＢＩ−Ｊ〕，ＤＥ値５５％）
※１０：ペクチン（コペンハーゲン ペクチンファクトリー社製，〔ＪＭＪ−Ｊ〕，ＤＥ値７０％）
（他成分）
キサンタンガム（大日本製薬社製，〔エコーガム〕）
ヒドロキシプロピルセルロース（日本曹達社製，〔ヒドロキシプロピルセルロース〕）
※１１：カルボキシビニルポリマー（ＢＦ Ｇｏｏｄｒｉｃｈ社製，〔ＣＡＲＢＯＰＯＬ９４０〕）
※１２：変性カルボキシビニルポリマー（ＬＵＢＲＩＺＯＬ社製，〔ＰＥＭＵＬＥＮ ＴＲ−１〕）In the examples and comparative examples, the following components were used.
((A) Electrolyte)
* 1: Zinc paraphenol sulfonate (Matsumoto Fine Chemical Co., Ltd. [Zinc sulfococolate])
* 2: Chlorhydroxyaluminum (manufactured by Summit Research Labs, [Micro Dry 3115])
* 3: Zinc pyrrolidone carboxylate (Ajinomoto Co., Inc. [AJIDEW ZN-100])
* 4: Calcium lactate (Musashino Chemical Laboratory, [Calcium lactate])
* 5: Dipotassium glycyrrhizinate (manufactured by Maruzen Pharmaceutical Co., Ltd. [dipotassium glycyrrhizinate])
((B) Nonionic polysaccharide thickener)
Locust Bean Gum (Ina Food Industry Co., Ltd. [Ingel Locust Bean Gum CS])
Tara gum (manufactured by Sanki Co., Ltd. [Spino Gum])
Guar gum (Ina Food Industry Co., Ltd. [Inagel Guar gum CS])
Hydroxypropyl guar gum (manufactured by Sankisha, [JAGUAR HP-8])
((C) Cross polymer)
* 6: POLYACRYLATE CROSSPOLYMER-6 (SEPPIC, [SEPIMAX ZE])
((D) Pectin)
* 7: Pectin (Copenhagen Pectin Factory, [LM-104AS-J], DE value 27%)
* 8: Pectin (Copenhagen Pectin Factory, [LM-101AS-J], DE value 35%)
* 9: Pectin (Copenhagen Pectin Factory, [BETA BI-J], DE value 55%)
* 10: Pectin (Copenhagen Pectin Factory, [JMJ-J], DE value 70%)
(Other ingredients)
Xanthan gum (Dainippon Pharmaceutical Co., Ltd., [Echo gum])
Hydroxypropylcellulose (Nippon Soda Co., Ltd., [hydroxypropylcellulose])
* 11: Carboxyvinyl polymer (manufactured by BF Goodrich, [CARBOPOL940])
* 12: Modified carboxyvinyl polymer (manufactured by LUBRIZOL, [PEMULEN TR-1])
（試料の調製１）
表１および表２に記した組成に従い、実施例１〜１５および比較例１〜１５の皮膚用組成物を常法に準じてジェル状となるように調製し、下記評価に供した。結果を表１および表２に併記する。尚、表中の配合量は、全て純分に換算した値である。(Sample preparation 1)
According to the composition described in Table 1 and Table 2, the skin composition of Examples 1-15 and Comparative Examples 1-15 was prepared so that it might become a gel form according to a conventional method, and it used for the following evaluation. The results are shown in Tables 1 and 2. In addition, all the compounding quantities in a table | surface are the values converted into the pure part.
（試験例１：製剤化の評価）
実施例および比較例で得られた各試料の製造直後の性状を目視観察して、以下の評価基準に従って評価した。(Test Example 1: Evaluation of formulation)
The properties immediately after production of each sample obtained in the examples and comparative examples were visually observed and evaluated according to the following evaluation criteria.
＜製剤化の評価基準＞
○（良好）：析出物および離水を生じることなく製剤化できる（ジェル化できる）
△（不十分）：若干の析出物は生じるが製剤化できる、又は若干の離水は生じるが製剤化できる（ジェル化できる）
×（不良）：明らかな析出物が生じて製剤化できない、又は明らかな離水が生じて製剤化できない（ジェル化しない）<Evaluation criteria for formulation>
○ (Good): Can be formulated without causing precipitate and water separation (can be gelled)
Δ (insufficient): Some precipitates are formed but can be formulated, or some water separation occurs but can be formulated (can be gelled)
X (Poor): A clear precipitate is formed and cannot be formulated, or a clear water separation occurs and cannot be formulated (no gel)
（試験例２：製剤安定性の評価）
実施例および比較例で得られた各試料を、５０ｍＬ容の透明ガラス容器にそれぞれ封入し、５℃の恒温槽に１週間保存したときの系の状態を目視観察して、以下の評価基準に従って評価した。尚、試験例１にてジェル化しないものについては、製剤安定性の評価に供していない。(Test Example 2: Evaluation of formulation stability)
Each sample obtained in Examples and Comparative Examples was sealed in a 50 mL transparent glass container, and the state of the system was visually observed when stored in a 5 ° C. constant temperature bath for 1 week. According to the following evaluation criteria: evaluated. In addition, about the thing which does not gel in Test Example 1, it has not used for evaluation of formulation stability.
＜製剤安定性の評価基準＞
○（良好）：析出物は一切認められずジェル状態を維持している
△（不十分）：若干の析出物が認められるがジェル状態を維持している
×（不良）：明らかな析出物が認められジェル状態を維持していない、又は析出物が増加しておりジェル状態を維持していない<Evaluation criteria for formulation stability>
○ (Good): No precipitates are observed and the gel state is maintained Δ (Insufficient): Some precipitates are observed but the gel state is maintained × (Poor): Clear precipitates are present Not recognized to maintain gel state, or increased deposits, not maintaining gel state
（試験例３：延展性の評価）
専門パネル２０名により、実施例および比較例で得られた各試料を顔面へ塗布して使用試験を行ってもらい、塗布時の延展性に関し、以下の評価基準に従って官能評価した。尚、試験例１にてジェル化しないものについては、延展性の評価に供していない。(Test Example 3: Evaluation of spreadability)
Twenty expert panels applied each sample obtained in the examples and comparative examples to the face to perform a use test, and sensory evaluation was performed according to the following evaluation criteria with respect to spreadability at the time of application. In addition, about the thing which does not become a gel in Test Example 1, it did not use for the evaluation of spreadability.
＜延展性の評価基準＞
◎（非常に良好）：２０名中１６名以上が、垂落ちがなく延展性に優れると回答
○（良好）：２０名中１１〜１５名が、垂落ちがなく延展性に優れると回答
△（不十分）：２０名中６〜１０名が、垂落ちがなく延展性に優れると回答
×（不良）：２０名中５名以下が、垂落ちがなく延展性に優れると回答<Evaluation criteria for spreadability>
◎ (very good): More than 16 out of 20 responded that there was no dripping and excellent spreadability ○ (good): 11-15 out of 20 responded that there was no dripping and excellent extensibility △ (Insufficient): 6-10 out of 20 responded that there is no dripping and excellent spreadability x (defect): 5 or less of 20 responded that there is no dripping and excellent extensibility
（試験例４：使用感の評価）
同パネル２０名により、試験例３の評価５分後、塗布部のヌルつき感およびベタつき感に関し、以下の評価基準に従って官能評価した。尚、試験例１にてジェル化しないものについては、使用感の評価に供していない。(Test Example 4: Evaluation of feeling of use)
After 20 minutes of the evaluation of Test Example 3, the panel 20 persons performed sensory evaluation according to the following evaluation criteria with respect to the feeling of nulliness and stickiness at the coating part. In addition, about what is not gelled in Test Example 1, it does not use for evaluation of a usability | use_condition.
＜使用感の評価基準＞
◎（非常に良好）：２０名中１６名以上が、ヌルつきやベタつきはないと回答
○（良好）：２０名中１１〜１５名が、ヌルつきやベタつきはないと回答
△（不十分）：２０名中６〜１０名が、ヌルつきやベタつきはないと回答
×（不良）：２０名中５名以下が、ヌルつきやベタつきはないと回答<Evaluation criteria for usability>
◎ (very good): More than 16 out of 20 responded that there was no null or sticky ○ (good): 11 to 15 out of 20 responded that there was no null or sticky △ (insufficient) : 6-10 out of 20 responded that there was no stickiness or stickiness x (defect): 5 or less of 20 respondents said there was no stickiness or stickiness
表１および表２に示された結果から、各実施例で得られた皮膚用ジェル状組成物は、各比較例で得られたものと対比して、電解質が存在する環境下であっても、析出物の発生や離水を抑制して容易にジェル化することができるとともに、その性状が安定に持続していることか分かる。また、塗布時の延展性に優れるだけでなく、ヌルつきやベタつきがなく、使用感に優れた効果を発揮していることが分かる。 From the results shown in Table 1 and Table 2, the gel-like composition for skin obtained in each example was compared with those obtained in each comparative example even in an environment where an electrolyte was present. It can be seen that the formation of precipitates and water separation can be easily suppressed to gelation, and that the properties are stably maintained. Moreover, it is understood that not only the spreadability at the time of application is excellent but also there is no stickiness or stickiness, and an excellent effect on the feeling of use is exhibited.
以下、本発明に係る皮膚用ジェル状組成物の処方例を示す。尚、含有量は質量％である。 Hereinafter, the formulation example of the gel-like composition for skin which concerns on this invention is shown. In addition, content is mass%.
（処方例１）
乳酸カルシウム １．０
濃グリセリン ２．０
ジプロピレングリコール ２．０
１，３−ブチレングリコール ２．０
ローカストビーンガム ０．４
グアーガム ０．４
ペクチン−※７ ０．２
クロスポリマー−※６ ０．８
エタノール ３．０
１，２−オクタンジオール ０．２
フェノキシエタノール ０．２
精製水 残部
合計 １００．０(Prescription Example 1)
Calcium lactate 1.0
Concentrated glycerin 2.0
Dipropylene glycol 2.0
1,3-butylene glycol 2.0
Locust Bean Gum 0.4
Guar gum 0.4
Pectin * 7 0.2
Cross polymer * 6 0.8
Ethanol 3.0
1,2-octanediol 0.2
Phenoxyethanol 0.2
Purified water balance 100.0
（処方例２）
クロルヒドロキシアルミニウム ５．０
１，３−ブチレングリコール ２．０
グアーガム ０．８
ペクチン−※７ ０．２
クロスポリマー−※６ ０．４
イソプロピルメチルフェノール ０．１
塩化ベンザルコニウム ０．１
ＰＰＧ−６デシルテトラデセス−２０ ０．３
メチルパラベン ０．２
フェノキシエタノール ０．３
エタノール ３．０
Ｌ−メントール ０．０５
精製水 残部
合計 １００．０(Prescription example 2)
Chlorhydroxyaluminum 5.0
1,3-butylene glycol 2.0
Guar gum 0.8
Pectin * 7 0.2
Cross polymer * 6 0.4
Isopropylmethylphenol 0.1
Benzalkonium chloride 0.1
PPG-6 decyltetradeceth-20 0.3
Methylparaben 0.2
Phenoxyethanol 0.3
Ethanol 3.0
L-Menthol 0.05
Purified water balance 100.0
（処方例３）
ピロリドンカルボン酸亜鉛 １．０
濃グリセリン ３．０
ジプロピレングリコール ２．０
１，３−ブチレングリコール ２．０
ローカストビーンガム ０．６
ペクチン−※７ ０．２
クロスポリマー−※６ ０．６
ナイロン末 ０．５
エタノール ３．０
メチルパラベン ０．３
フェノキシエタノール ０．３
Ｌ−メントール ０．０５
ＰＰＧ−６デシルテトラデセス−２０ ０．３
精製水 残部
合計 １００．０(Prescription Example 3)
Zinc pyrrolidonecarboxylate 1.0
Concentrated glycerin 3.0
Dipropylene glycol 2.0
1,3-butylene glycol 2.0
Locust Bean Gum 0.6
Pectin * 7 0.2
Cross polymer * 6 0.6
Nylon powder 0.5
Ethanol 3.0
Methylparaben 0.3
Phenoxyethanol 0.3
L-Menthol 0.05
PPG-6 decyltetradeceth-20 0.3
Purified water balance 100.0
本発明の皮膚用ジェル状組成物は、電解質が存在する環境下であっても容易にジェル化することができ、そのジェル化製剤の安定性に優れた効果を発揮し、塗布時の延展性や使用感に優れることから、皮膚用の化粧料として好ましく用いられる。 The gel composition for skin of the present invention can be easily gelled even in an environment where an electrolyte is present, exhibits an excellent effect on the stability of the gelled preparation, and spreadability at the time of application. In addition, it is preferably used as a cosmetic for skin because of its excellent usability.
Claims (6)
（Ｃ１）（メタ）アクリルアミドメチルプロパンスルホン酸塩、
（Ｃ２）ジメチル（メタ）アクリルアミド、
（Ｃ３）（メタ）アクリル酸アルキル、
（Ｃ４）（メタ）アクリル酸ポリオキシエチレンアルキルエーテル A gel-like composition for skin containing (A) an electrolyte, (B) a nonionic polysaccharide compound, and (C) a cross polymer formed using the following (C1) to (C4) as essential monomer components.
(C1) (meth) acrylamidomethylpropane sulfonate,
(C2) dimethyl (meth) acrylamide,
(C3) alkyl (meth) acrylate,
(C4) (Meth) acrylic acid polyoxyethylene alkyl ether
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| JP2013038761 | 2013-02-28 | ||
| PCT/JP2014/053003 WO2014132783A1 (en) | 2013-02-28 | 2014-02-10 | Gel composition for skin |
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|---|---|---|---|---|
| JP6725470B2 (en) * | 2016-10-18 | 2020-07-22 | 花王株式会社 | Cosmetics |
| EP3677249B1 (en) | 2017-08-31 | 2024-08-21 | Shiseido Company, Ltd. | Cosmetic base and skin cosmetic using same |
| DE212017000348U1 (en) * | 2017-12-18 | 2020-09-11 | Suzhou Synerguar Hydrocolloid Technology Co., Ltd. | Hydroxypropyl guar gum |
| JPWO2019171843A1 (en) * | 2018-03-05 | 2021-02-25 | パナソニックＩｐマネジメント株式会社 | Cosmetics or medical materials |
| JP2020152688A (en) * | 2019-03-22 | 2020-09-24 | 株式会社マンダム | Cosmetic composition |
| FR3106979B1 (en) * | 2020-02-12 | 2022-07-22 | Soc Dexploitation De Produits Pour Les Industries Chimiques Seppic | Composition for topical use in the form of a gel comprising mineralization water |
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- 2014-02-10 JP JP2015502844A patent/JP5989226B2/en active Active
- 2014-02-10 CN CN201480003315.XA patent/CN104837475A/en active Pending
- 2014-02-10 CN CN201811249671.6A patent/CN109481329A/en active Pending
- 2014-02-10 CN CN201480003318.3A patent/CN104884032B/en active Active
- 2014-02-10 WO PCT/JP2014/053004 patent/WO2014132784A1/en active Application Filing
- 2014-02-10 JP JP2015502845A patent/JP5989227B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| CN104837475A (en) | 2015-08-12 |
| JP5989227B2 (en) | 2016-09-07 |
| CN104884032B (en) | 2017-07-25 |
| JPWO2014132784A1 (en) | 2017-02-02 |
| CN109481329A (en) | 2019-03-19 |
| JPWO2014132783A1 (en) | 2017-02-02 |
| WO2014132783A1 (en) | 2014-09-04 |
| WO2014132784A1 (en) | 2014-09-04 |
| CN104884032A (en) | 2015-09-02 |
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