JP5817085B1 - Hair dye composition - Google Patents
Hair dye composition Download PDFInfo
- Publication number
- JP5817085B1 JP5817085B1 JP2015002995A JP2015002995A JP5817085B1 JP 5817085 B1 JP5817085 B1 JP 5817085B1 JP 2015002995 A JP2015002995 A JP 2015002995A JP 2015002995 A JP2015002995 A JP 2015002995A JP 5817085 B1 JP5817085 B1 JP 5817085B1
- Authority
- JP
- Japan
- Prior art keywords
- hair
- hair dye
- dye composition
- oil
- mass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000118 hair dye Substances 0.000 title claims abstract description 115
- 239000000203 mixture Substances 0.000 title claims abstract description 93
- 210000004209 hair Anatomy 0.000 claims abstract description 138
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 48
- 239000000975 dye Substances 0.000 claims abstract description 40
- 239000002245 particle Substances 0.000 claims abstract description 25
- 239000003921 oil Substances 0.000 claims description 49
- 239000004094 surface-active agent Substances 0.000 claims description 25
- 239000003093 cationic surfactant Substances 0.000 claims description 23
- 239000007787 solid Substances 0.000 claims description 15
- OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims description 13
- 239000012071 phase Substances 0.000 claims description 9
- 239000008346 aqueous phase Substances 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims 1
- 239000008384 inner phase Substances 0.000 claims 1
- 239000008385 outer phase Substances 0.000 claims 1
- 238000004043 dyeing Methods 0.000 abstract description 51
- 239000000839 emulsion Substances 0.000 abstract description 33
- 229920000642 polymer Polymers 0.000 abstract description 24
- 238000006068 polycondensation reaction Methods 0.000 abstract description 23
- 230000007794 irritation Effects 0.000 abstract description 19
- 239000000126 substance Substances 0.000 abstract description 12
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 11
- 235000019198 oils Nutrition 0.000 description 42
- -1 fatty acid esters Chemical class 0.000 description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- 235000014113 dietary fatty acids Nutrition 0.000 description 22
- 239000000194 fatty acid Substances 0.000 description 22
- 229930195729 fatty acid Natural products 0.000 description 22
- 210000002472 endoplasmic reticulum Anatomy 0.000 description 21
- 230000000052 comparative effect Effects 0.000 description 19
- 239000001026 semi permanent hair color Substances 0.000 description 15
- 235000019441 ethanol Nutrition 0.000 description 14
- 238000002156 mixing Methods 0.000 description 12
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 10
- 125000000217 alkyl group Chemical group 0.000 description 10
- 239000001024 permanent hair color Substances 0.000 description 10
- 150000003904 phospholipids Chemical class 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 9
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 9
- PLIKAWJENQZMHA-UHFFFAOYSA-N 4-aminophenol Chemical compound NC1=CC=C(O)C=C1 PLIKAWJENQZMHA-UHFFFAOYSA-N 0.000 description 8
- 125000003342 alkenyl group Chemical group 0.000 description 8
- 229960000541 cetyl alcohol Drugs 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 239000000787 lecithin Substances 0.000 description 7
- 235000010445 lecithin Nutrition 0.000 description 7
- 229940067606 lecithin Drugs 0.000 description 7
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- 239000004166 Lanolin Substances 0.000 description 6
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 6
- 235000019388 lanolin Nutrition 0.000 description 6
- 229940039717 lanolin Drugs 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 230000035515 penetration Effects 0.000 description 6
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 125000002091 cationic group Chemical group 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000001804 emulsifying effect Effects 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 description 4
- CWLKGDAVCFYWJK-UHFFFAOYSA-N 3-aminophenol Chemical compound NC1=CC=CC(O)=C1 CWLKGDAVCFYWJK-UHFFFAOYSA-N 0.000 description 4
- 239000004359 castor oil Substances 0.000 description 4
- 235000019438 castor oil Nutrition 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 239000010466 nut oil Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- WZCQRUWWHSTZEM-UHFFFAOYSA-N 1,3-phenylenediamine Chemical compound NC1=CC=CC(N)=C1 WZCQRUWWHSTZEM-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical class N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 3
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 3
- 240000000912 Macadamia tetraphylla Species 0.000 description 3
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 3
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 229960001231 choline Drugs 0.000 description 3
- 229960000735 docosanol Drugs 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 229940043348 myristyl alcohol Drugs 0.000 description 3
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 235000019271 petrolatum Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000001027 temporary hair color Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KJCVRFUGPWSIIH-UHFFFAOYSA-N 1-naphthol Chemical compound C1=CC=C2C(O)=CC=CC2=C1 KJCVRFUGPWSIIH-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- 229940113490 2,4-diaminophenoxyethanol hydrochloride Drugs 0.000 description 2
- PBVFDMZFBPZIMC-UHFFFAOYSA-N 2-(2,4-diaminophenoxy)ethanol;hydrochloride Chemical compound Cl.NC1=CC=C(OCCO)C(N)=C1 PBVFDMZFBPZIMC-UHFFFAOYSA-N 0.000 description 2
- OBCSAIDCZQSFQH-UHFFFAOYSA-N 2-methyl-1,4-phenylenediamine Chemical compound CC1=CC(N)=CC=C1N OBCSAIDCZQSFQH-UHFFFAOYSA-N 0.000 description 2
- DBFYESDCPWWCHN-UHFFFAOYSA-N 5-amino-2-methylphenol Chemical compound CC1=CC=C(N)C=C1O DBFYESDCPWWCHN-UHFFFAOYSA-N 0.000 description 2
- PNENOUKIPPERMY-UHFFFAOYSA-N HC Yellow No. 4 Chemical compound OCCNC1=CC=C([N+]([O-])=O)C=C1OCCO PNENOUKIPPERMY-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000004264 Petrolatum Substances 0.000 description 2
- 241001122767 Theaceae Species 0.000 description 2
- XKMYWNHZAQUEPY-YZGJEOKZSA-N [(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-yl] 12-hydroxyoctadecanoate Chemical compound C([C@@H]12)C[C@]3(C)[C@@H]([C@H](C)CCCC(C)C)CC[C@H]3[C@@H]1CC=C1[C@]2(C)CC[C@H](OC(=O)CCCCCCCCCCC(O)CCCCCC)C1 XKMYWNHZAQUEPY-YZGJEOKZSA-N 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 239000002280 amphoteric surfactant Substances 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 239000012911 assay medium Substances 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- 150000001841 cholesterols Chemical class 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000003752 improving hair Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 235000010446 mineral oil Nutrition 0.000 description 2
- 229920005615 natural polymer Polymers 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 2
- SECPZKHBENQXJG-FPLPWBNLSA-N palmitoleic acid Chemical compound CCCCCC\C=C/CCCCCCCC(O)=O SECPZKHBENQXJG-FPLPWBNLSA-N 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 229940066842 petrolatum Drugs 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 229960001755 resorcinol Drugs 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 229940081974 saccharin Drugs 0.000 description 2
- 235000019204 saccharin Nutrition 0.000 description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- 239000001993 wax Substances 0.000 description 2
- IHWGANISMYLGDC-UHFFFAOYSA-N (2-amino-5-nitrophenyl) hydrogen sulfate Chemical compound NC1=CC=C([N+]([O-])=O)C=C1OS(O)(=O)=O IHWGANISMYLGDC-UHFFFAOYSA-N 0.000 description 1
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 description 1
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- FBMQNRKSAWNXBT-UHFFFAOYSA-N 1,4-diaminoanthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(N)=CC=C2N FBMQNRKSAWNXBT-UHFFFAOYSA-N 0.000 description 1
- FRASJONUBLZVQX-UHFFFAOYSA-N 1,4-dioxonaphthalene Natural products C1=CC=C2C(=O)C=CC(=O)C2=C1 FRASJONUBLZVQX-UHFFFAOYSA-N 0.000 description 1
- BOKGTLAJQHTOKE-UHFFFAOYSA-N 1,5-dihydroxynaphthalene Chemical compound C1=CC=C2C(O)=CC=CC2=C1O BOKGTLAJQHTOKE-UHFFFAOYSA-N 0.000 description 1
- ICVRBKCRXNVOJC-UHFFFAOYSA-N 1-amino-4-(methylamino)anthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C(N)=CC=C2NC ICVRBKCRXNVOJC-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- ZONJATNKKGGVSU-UHFFFAOYSA-N 14-methylpentadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCC(O)=O ZONJATNKKGGVSU-UHFFFAOYSA-N 0.000 description 1
- VPMMJSPGZSFEAH-UHFFFAOYSA-N 2,4-diaminophenol;hydrochloride Chemical compound [Cl-].NC1=CC=C(O)C([NH3+])=C1 VPMMJSPGZSFEAH-UHFFFAOYSA-N 0.000 description 1
- KZTWOUOZKZQDMN-UHFFFAOYSA-N 2,5-diaminotoluene sulfate Chemical compound OS(O)(=O)=O.CC1=CC(N)=CC=C1N KZTWOUOZKZQDMN-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- VLZVIIYRNMWPSN-UHFFFAOYSA-N 2-Amino-4-nitrophenol Chemical compound NC1=CC([N+]([O-])=O)=CC=C1O VLZVIIYRNMWPSN-UHFFFAOYSA-N 0.000 description 1
- DOPJTDJKZNWLRB-UHFFFAOYSA-N 2-Amino-5-nitrophenol Chemical compound NC1=CC=C([N+]([O-])=O)C=C1O DOPJTDJKZNWLRB-UHFFFAOYSA-N 0.000 description 1
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical compound NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 1
- BNOCVKCSBKRYHN-UHFFFAOYSA-N 2-aminophenol;sulfuric acid Chemical compound OS(O)(=O)=O.NC1=CC=CC=C1O BNOCVKCSBKRYHN-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
- OYINQIKIQCNQOX-UHFFFAOYSA-M 2-hydroxybutyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCC(O)C[N+](C)(C)C OYINQIKIQCNQOX-UHFFFAOYSA-M 0.000 description 1
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 1
- HVHNMNGARPCGGD-UHFFFAOYSA-N 2-nitro-p-phenylenediamine Chemical compound NC1=CC=C(N)C([N+]([O-])=O)=C1 HVHNMNGARPCGGD-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- JSQGOXTYKZBABW-UHFFFAOYSA-N 3-(3-hydroxyanilino)phenol Chemical compound OC1=CC=CC(NC=2C=C(O)C=CC=2)=C1 JSQGOXTYKZBABW-UHFFFAOYSA-N 0.000 description 1
- AZKSAVLVSZKNRD-UHFFFAOYSA-M 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide Chemical compound [Br-].S1C(C)=C(C)N=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 AZKSAVLVSZKNRD-UHFFFAOYSA-M 0.000 description 1
- WGVGLSURTKMQQC-UHFFFAOYSA-N 3-aminopropyl-ethyl-dimethylazanium Chemical compound CC[N+](C)(C)CCCN WGVGLSURTKMQQC-UHFFFAOYSA-N 0.000 description 1
- VFKZECOCJCGZQK-UHFFFAOYSA-M 3-hydroxypropyl(trimethyl)azanium;chloride Chemical compound [Cl-].C[N+](C)(C)CCCO VFKZECOCJCGZQK-UHFFFAOYSA-M 0.000 description 1
- HSDSBIUUVWRHTM-UHFFFAOYSA-N 4-(2-nitroanilino)phenol Chemical compound C1=CC(O)=CC=C1NC1=CC=CC=C1[N+]([O-])=O HSDSBIUUVWRHTM-UHFFFAOYSA-N 0.000 description 1
- ZFIQGRISGKSVAG-UHFFFAOYSA-N 4-methylaminophenol Chemical compound CNC1=CC=C(O)C=C1 ZFIQGRISGKSVAG-UHFFFAOYSA-N 0.000 description 1
- ZVNPWFOVUDMGRP-UHFFFAOYSA-N 4-methylaminophenol sulfate Chemical compound OS(O)(=O)=O.CNC1=CC=C(O)C=C1.CNC1=CC=C(O)C=C1 ZVNPWFOVUDMGRP-UHFFFAOYSA-N 0.000 description 1
- DGRGLKZMKWPMOH-UHFFFAOYSA-N 4-methylbenzene-1,2-diamine Chemical compound CC1=CC=C(N)C(N)=C1 DGRGLKZMKWPMOH-UHFFFAOYSA-N 0.000 description 1
- UIBDOIWJPGLGEJ-UHFFFAOYSA-N 4-n-(4-aminophenyl)benzene-1,4-diamine;sulfuric acid Chemical compound [O-]S([O-])(=O)=O.C1=CC(N)=CC=C1[NH2+]C1=CC=C(N)C=C1.C1=CC(N)=CC=C1[NH2+]C1=CC=C(N)C=C1 UIBDOIWJPGLGEJ-UHFFFAOYSA-N 0.000 description 1
- RAUWPNXIALNKQM-UHFFFAOYSA-N 4-nitro-1,2-phenylenediamine Chemical compound NC1=CC=C([N+]([O-])=O)C=C1N RAUWPNXIALNKQM-UHFFFAOYSA-N 0.000 description 1
- YGRFRBUGAPOJDU-UHFFFAOYSA-N 5-(2-hydroxyethylamino)-2-methylphenol Chemical compound CC1=CC=C(NCCO)C=C1O YGRFRBUGAPOJDU-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 235000019489 Almond oil Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 238000011891 EIA kit Methods 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- KIWBPDUYBMNFTB-UHFFFAOYSA-N Ethyl hydrogen sulfate Chemical compound CCOS(O)(=O)=O KIWBPDUYBMNFTB-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- MIWUTEVJIISHCP-UHFFFAOYSA-N HC Blue No. 2 Chemical compound OCCNC1=CC=C(N(CCO)CCO)C=C1[N+]([O-])=O MIWUTEVJIISHCP-UHFFFAOYSA-N 0.000 description 1
- MWJSMPQOVHQYTE-UHFFFAOYSA-N HC Blue No.1 Chemical compound CNC1=CC=C(N(CCO)CCO)C=C1[N+]([O-])=O MWJSMPQOVHQYTE-UHFFFAOYSA-N 0.000 description 1
- GZGZVOLBULPDFD-UHFFFAOYSA-N HC Red No. 3 Chemical compound NC1=CC=C(NCCO)C([N+]([O-])=O)=C1 GZGZVOLBULPDFD-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 231100000960 LabCyte EPI-MODEL 24 Toxicity 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021319 Palmitoleic acid Nutrition 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 1
- RFQSMLBZXQOMKK-UHFFFAOYSA-N [3-[(4,8-diamino-6-bromo-1,5-dioxonaphthalen-2-yl)amino]phenyl]-trimethylazanium;chloride Chemical compound [Cl-].C[N+](C)(C)C1=CC=CC(NC=2C(C3=C(N)C=C(Br)C(=O)C3=C(N)C=2)=O)=C1 RFQSMLBZXQOMKK-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- BLBQLCUTOHDPJM-UHFFFAOYSA-N acetic acid;4-n-phenylbenzene-1,4-diamine Chemical compound CC(O)=O.C1=CC(N)=CC=C1NC1=CC=CC=C1 BLBQLCUTOHDPJM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000003973 alkyl amines Chemical class 0.000 description 1
- 150000004996 alkyl benzenes Chemical class 0.000 description 1
- 125000005211 alkyl trimethyl ammonium group Chemical group 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229940077388 benzenesulfonate Drugs 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 239000003012 bilayer membrane Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- AYFCVLSUPGCQKD-UHFFFAOYSA-I calcium;trisodium;2-[bis[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate Chemical compound [Na+].[Na+].[Na+].[Ca+2].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)CC([O-])=O AYFCVLSUPGCQKD-UHFFFAOYSA-I 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-O carboxymethyl-[3-(dodecanoylamino)propyl]-dimethylazanium Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC(O)=O MRUAUOIMASANKQ-UHFFFAOYSA-O 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- WOWHHFRSBJGXCM-UHFFFAOYSA-M cetyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)C WOWHHFRSBJGXCM-UHFFFAOYSA-M 0.000 description 1
- RLGQACBPNDBWTB-UHFFFAOYSA-N cetyltrimethylammonium ion Chemical compound CCCCCCCCCCCCCCCC[N+](C)(C)C RLGQACBPNDBWTB-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Natural products C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 1
- 229940072104 cholesteryl hydroxystearate Drugs 0.000 description 1
- SECPZKHBENQXJG-UHFFFAOYSA-N cis-palmitoleic acid Natural products CCCCCCC=CCCCCCCCC(O)=O SECPZKHBENQXJG-UHFFFAOYSA-N 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- UKJLNMAFNRKWGR-UHFFFAOYSA-N cyclohexatrienamine Chemical group NC1=CC=C=C[CH]1 UKJLNMAFNRKWGR-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 125000005131 dialkylammonium group Chemical group 0.000 description 1
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 description 1
- BPHQZTVXXXJVHI-UHFFFAOYSA-N dimyristoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-UHFFFAOYSA-N 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 description 1
- NJDNXYGOVLYJHP-UHFFFAOYSA-L disodium;2-(3-oxido-6-oxoxanthen-9-yl)benzoate Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=CC(=O)C=C2OC2=CC([O-])=CC=C21 NJDNXYGOVLYJHP-UHFFFAOYSA-L 0.000 description 1
- GLSRFBDXBWZNLH-UHFFFAOYSA-L disodium;2-chloroacetate;2-(4,5-dihydroimidazol-1-yl)ethanol;hydroxide Chemical compound [OH-].[Na+].[Na+].[O-]C(=O)CCl.OCCN1CCN=C1 GLSRFBDXBWZNLH-UHFFFAOYSA-L 0.000 description 1
- 239000004664 distearyldimethylammonium chloride (DHTDMAC) Substances 0.000 description 1
- QIVLQXGSQSFTIF-UHFFFAOYSA-M docosyl(trimethyl)azanium;methyl sulfate Chemical compound COS([O-])(=O)=O.CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C QIVLQXGSQSFTIF-UHFFFAOYSA-M 0.000 description 1
- DDXLVDQZPFLQMZ-UHFFFAOYSA-M dodecyl(trimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)C DDXLVDQZPFLQMZ-UHFFFAOYSA-M 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- MJEMIOXXNCZZFK-UHFFFAOYSA-N ethylone Chemical compound CCNC(C)C(=O)C1=CC=C2OCOC2=C1 MJEMIOXXNCZZFK-UHFFFAOYSA-N 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 125000004395 glucoside group Chemical group 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 230000003700 hair damage Effects 0.000 description 1
- 230000003699 hair surface Effects 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 229960002163 hydrogen peroxide Drugs 0.000 description 1
- 229920006007 hydrogenated polyisobutylene Polymers 0.000 description 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 1
- PNEVDCGZQWFIKV-UHFFFAOYSA-N hydron;4-n-phenylbenzene-1,4-diamine;chloride Chemical compound Cl.C1=CC(N)=CC=C1NC1=CC=CC=C1 PNEVDCGZQWFIKV-UHFFFAOYSA-N 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000001165 hydrophobic group Chemical group 0.000 description 1
- 229960004337 hydroquinone Drugs 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940075468 lauramidopropyl betaine Drugs 0.000 description 1
- 229940094506 lauryl betaine Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- PETZRPLPRZXTAD-UHFFFAOYSA-N n-(4-aminophenyl)nitramide;hydrochloride Chemical compound Cl.NC1=CC=C(N[N+]([O-])=O)C=C1 PETZRPLPRZXTAD-UHFFFAOYSA-N 0.000 description 1
- OUWSWIUKTXTNRI-UHFFFAOYSA-N n-(4-aminophenyl)nitramide;sulfuric acid Chemical compound OS(O)(=O)=O.NC1=CC=C(N[N+]([O-])=O)C=C1 OUWSWIUKTXTNRI-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 235000019488 nut oil Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- ATGUVEKSASEFFO-UHFFFAOYSA-N p-aminodiphenylamine Chemical compound C1=CC(N)=CC=C1NC1=CC=CC=C1 ATGUVEKSASEFFO-UHFFFAOYSA-N 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 235000019809 paraffin wax Nutrition 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- QCDYQQDYXPDABM-UHFFFAOYSA-N phloroglucinol Chemical compound OC1=CC(O)=CC(O)=C1 QCDYQQDYXPDABM-UHFFFAOYSA-N 0.000 description 1
- 229960001553 phloroglucinol Drugs 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- QXYMVUZOGFVPGH-UHFFFAOYSA-N picramic acid Chemical compound NC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O QXYMVUZOGFVPGH-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001083 polybutene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- VHNQIURBCCNWDN-UHFFFAOYSA-N pyridine-2,6-diamine Chemical compound NC1=CC=CC(N)=N1 VHNQIURBCCNWDN-UHFFFAOYSA-N 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 description 1
- 229960003656 ricinoleic acid Drugs 0.000 description 1
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000002453 shampoo Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229940096501 sodium cocoamphoacetate Drugs 0.000 description 1
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 description 1
- UENNEPPWFZYINW-UHFFFAOYSA-M sodium;2-amino-4,6-dinitrophenolate Chemical compound [Na+].NC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1[O-] UENNEPPWFZYINW-UHFFFAOYSA-M 0.000 description 1
- STZCRXQWRGQSJD-UHFFFAOYSA-N sodium;4-[[4-(dimethylamino)phenyl]diazenyl]benzenesulfonic acid Chemical compound [Na+].C1=CC(N(C)C)=CC=C1N=NC1=CC=C(S(O)(=O)=O)C=C1 STZCRXQWRGQSJD-UHFFFAOYSA-N 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- PDSVZUAJOIQXRK-UHFFFAOYSA-N trimethyl(octadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)C PDSVZUAJOIQXRK-UHFFFAOYSA-N 0.000 description 1
- SZEMGTQCPRNXEG-UHFFFAOYSA-M trimethyl(octadecyl)azanium;bromide Chemical compound [Br-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C SZEMGTQCPRNXEG-UHFFFAOYSA-M 0.000 description 1
- RRHXZLALVWBDKH-UHFFFAOYSA-M trimethyl-[2-(2-methylprop-2-enoyloxy)ethyl]azanium;chloride Chemical compound [Cl-].CC(=C)C(=O)OCC[N+](C)(C)C RRHXZLALVWBDKH-UHFFFAOYSA-M 0.000 description 1
- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
【課題】染毛性に優れかつ毛髪に対して低刺激である染毛剤組成物を提供すること。【解決手段】染毛剤組成物は、油剤、水性成分および染料を含み、油剤の少なくとも一部が、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子で包囲された構造体の内側に位置しており、水性成分の少なくとも一部が、前記構造体の外側に位置し、Ｏ／Ｗ型エマルションである。【選択図】図１[Problem] To provide a hair dye composition having excellent hair dyeing properties and low irritation to hair. A hair dye composition includes an oil agent, an aqueous component, and a dye, and at least a part of the oil agent has closed vesicles or hydroxyl groups formed by an amphipathic substance that spontaneously forms closed vesicles. It is located inside the structure surrounded by the polycondensation polymer particles, and at least a part of the aqueous component is located outside the structure and is an O / W emulsion. [Selection] Figure 1
Description
本発明は、染毛剤組成物に関する。 The present invention relates to a hair dye composition.
白髪を黒く染めることや毛髪を自分好みの色に変化させることを目的として、染毛剤組成物は世の中で広く使用されている。染毛剤組成物は、永久染毛剤（パーマネントヘアカラー）、半永久染毛料（セミパーマネントヘアカラー）、一時染毛料などに分類される。このうち、永久染毛剤は最も使用されている。永久染毛剤の中でも、酸化染料を発色させて着色する酸化染毛剤は、色持ちが良く、仕上がりも鮮明であることから、最も広く使用されている。しかし、酸化染毛剤は、刺激性が強いため、毛髪を損傷させてしまい髪本来のツヤや質感をなくしてしまうという欠点を持つ。一方、半永久染毛料は、毛髪を損傷させにくいが、染毛するためには複数回使用し続けることが必要であり手間がかかるという欠点や、永久染毛剤に比べて色持ちが悪いという欠点を持つ。したがって、染毛剤組成物の分野において、高い染毛性と毛髪への低刺激性を両立させることは共通した課題である。 Hair dye compositions are widely used in the world for the purpose of dyeing gray hair black or changing hair to a color of your choice. Hair dye compositions are classified into permanent hair dyes (permanent hair colors), semi-permanent hair dyes (semi-permanent hair colors), temporary hair dyes, and the like. Of these, permanent hair dyes are most used. Among permanent hair dyes, the oxidative hair dyes that are colored by coloring an oxidative dye are most widely used because they have good color and a clear finish. However, since the oxidative hair dye is highly irritating, it has the disadvantage of damaging the hair and losing its original gloss and texture. On the other hand, semi-permanent hair dyes are hard to damage hair, but it is necessary to continue to use multiple times in order to dye hair, and it takes time and labor, and it has poor color lasting compared to permanent hair dyes. have. Therefore, in the field of hair dye compositions, it is a common problem to achieve both high hair dyeing properties and low irritation to hair.
永久染毛剤や半永久染毛料などの染毛剤組成物は、アルカリ剤で毛髪を膨潤させて、キューティクルの隙間から染料を浸透させることによって毛髪を染色する。このような染毛剤組成物はカチオン性界面活性剤などの界面活性剤を含むことによって染毛性が向上することが知られている。そのため、染毛剤組成物の多くはカチオン性界面活性剤などの界面活性剤を含んでいる（例えば特許文献１参照）。このような染毛剤組成物は、カチオン性界面活性剤などの界面活性剤が毛髪のキューティクルの隙間へ入り込み吸着することにより、キューティクルが開いた状態のまま保たれる。それにより、染料の毛髪内への侵入または毛髪への付着が促進されるため、染毛剤組成物の染毛性が向上している。 Hair dye compositions such as permanent hair dyes and semi-permanent hair dyes swell hair with an alkaline agent and dye the hair by allowing the dye to permeate through the gaps in the cuticle. Such a hair dye composition is known to improve hair dyeability by containing a surfactant such as a cationic surfactant. Therefore, many hair dye compositions contain a surfactant such as a cationic surfactant (see, for example, Patent Document 1). In such a hair dye composition, a surfactant such as a cationic surfactant enters the gap between the cuticles of the hair and is adsorbed, whereby the cuticle is kept open. Thereby, since the penetration | invasion of the dye into hair or adhesion to hair is accelerated | stimulated, the hair dyeing property of the hair dye composition has improved.
しかし、このような従来の染毛剤組成物は、染毛性を向上させるために、カチオン性界面活性剤などの界面活性剤を多量に含む必要がある。カチオン性界面活性剤などの界面活性剤は刺激性が高いため、染毛剤組成物の染毛性と刺激性とはトレードオフの関係になりやすい。したがって、染毛性を向上させつつ、しかも刺激性を低下させた染毛剤組成物の開発が求められてきた。 However, such a conventional hair dye composition needs to contain a large amount of a surfactant such as a cationic surfactant in order to improve the hair dyeability. Since surfactants such as cationic surfactants have high irritation, the hair dyeing properties and irritation of the hair dye composition tend to be in a trade-off relationship. Therefore, there has been a demand for the development of a hair dye composition having improved hair dyeing properties and reduced irritation.
本発明は、以上の実情に鑑みてなされたものであり、染毛性に優れかつ毛髪に対して低刺激である染毛剤組成物を提供することを目的とする。 This invention is made | formed in view of the above situation, and it aims at providing the hair dye composition which is excellent in hair dyeing property and is low irritation | stimulation with respect to hair.
本発明者らは、油剤の少なくとも一部が、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子で包囲された構造体を形成し、前記構造体が染毛剤組成物に含まれることにより、毛髪に対して低刺激にもかかわらず、染毛性を向上し得ることを見出し、本発明を完成するに至った。具体的に、本発明は以下を提供する。 The inventors of the present invention form a structure in which at least a part of the oil agent is surrounded by a closed vesicle formed by an amphiphile that spontaneously forms a closed vesicle or a polycondensation polymer particle having a hydroxyl group. It has been found that, by including the structure in the hair dye composition, the hair dyeability can be improved in spite of low irritation to the hair, and the present invention has been completed. Specifically, the present invention provides the following.
（１） 油剤、水性成分および染料を含み、
油剤の少なくとも一部が、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子で包囲された構造体の内側に位置しており、
水性成分の少なくとも一部が、前記構造体の外側に位置し、Ｏ／Ｗ型エマルションである染毛剤組成物。
(1) Contains oil agent, aqueous component and dye,
At least a portion of the oil agent is located inside a structure surrounded by polycondensation polymer particles having closed vesicles or hydroxyl groups formed by amphiphiles that spontaneously form closed vesicles;
A hair dye composition, wherein at least a part of the aqueous component is located outside the structure and is an O / W emulsion.
（２） 前記油剤は、抱水性油剤、または２０℃において固形である固形油から選択される１種以上の油剤を含有する（１）記載の染毛剤組成物。 (2) The hair dye composition according to (1), wherein the oil agent contains one or more oil agents selected from a water-holding oil agent or a solid oil that is solid at 20 ° C.
（３） 更に、界面活性剤を含有する（１）または（２）記載の染毛剤組成物。 (3) The hair dye composition according to (1) or (2), further comprising a surfactant.
（４） 染料の少なくとも一部は、前記構造体の外側に位置する（１）から（３）いずれか記載の染毛剤組成物。 (4) The hair dye composition according to any one of (1) to (3), wherein at least a part of the dye is located outside the structure.
（５） ダメージ毛用である（１）から（４）いずれか記載の染毛剤組成物。 (5) The hair dye composition according to any one of (1) to (4), which is for damaged hair.
本発明によれば、染毛剤組成物に含まれる油剤の少なくとも一部が、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子で包囲された構造体を形成することにより、染毛性に優れかつ毛髪に対して低刺激である染毛剤組成物を提供することができる。 According to the present invention, at least a part of the oil contained in the hair dye composition is a polycondensation polymer particle having a closed vesicle or a hydroxyl group formed by an amphiphile that spontaneously forms a closed vesicle. By forming an enclosed structure, it is possible to provide a hair dye composition that is excellent in hair dyeing properties and is less irritating to hair.
以下、本発明の実施形態を説明するが、これらに本発明が限定されるものではない。 Hereinafter, although embodiment of this invention is described, this invention is not limited to these.
本発明に係る染毛剤組成物は、油剤、水性成分および染料を含み、油剤の少なくとも一部が、自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子で包囲された構造体の内側に位置しており、水性成分の少なくとも一部が、前記構造体の外側に位置し、Ｏ／Ｗ型エマルションであることを特徴とする。これにより、毛髪に対して低刺激であるにもかかわらず、染毛性を向上することができる。 The hair dye composition according to the present invention comprises an oil agent, an aqueous component and a dye, and at least a part of the oil agent has a closed vesicle or hydroxyl group formed by an amphipathic substance that spontaneously forms a closed vesicle. It is located inside the structure surrounded by the polycondensation polymer particles, and at least a part of the aqueous component is located outside the structure and is an O / W emulsion. Thereby, although it is low irritation | stimulation with respect to hair, hair dyeing property can be improved.
閉鎖小胞体または重縮合ポリマー粒子は、いずれも親水性の粒子であり、ファンデルワールス力によって水相と油相との界面に介在することで、乳化状態を維持する。この作用は、親水性部分および疎水性部分をそれぞれ水相および油相に向け、相間の界面張力を下げることで乳化状態を維持する界面活性剤とは全く異なる（例えば特許３８５５２０３号公報参照）。 Closed endoplasmic reticulum or polycondensation polymer particles are all hydrophilic particles, and maintain an emulsified state by being interposed at the interface between the water phase and the oil phase by van der Waals force. This action is completely different from the surfactant that maintains the emulsified state by directing the hydrophilic part and the hydrophobic part to the aqueous phase and the oil phase, respectively, and lowering the interfacial tension between the phases (see, for example, Japanese Patent No. 3855203).
前記効果が奏される機構は、特に限定されないが、次のように推測される。
前記構造体は、油剤が表面親水性の閉鎖小胞体または重縮合ポリマー粒子で包囲された構造を有しており、分子として遊離する染料やカチオン性界面活性剤などの界面活性剤に比べてサイズが大きい。したがって、前記構造体の移動速度は、染料やカチオン性界面活性剤などの界面活性剤に比べて遅い。そのため、前記構造体がキューティクルに付着するよりも前に、多くの染料は毛髪内に侵入または毛髪に付着することができると考えられる。よって、前記構造体は、染料の毛髪内への侵入または毛髪への付着を阻害しにくい。しかも、染料が毛髪内に侵入又付着した後、前記構造体がキューティクル表面に付着することにより、侵入または付着した染料が流失することを抑制できる。これにより、染毛性が向上するので、短時間で効率良く染毛を終えて、染毛剤組成物を毛髪から洗い流すことが可能となる。そのため、染毛剤組成物が毛髪に接触する時間が短くなるため、毛髪へのダメージ（毛髪への刺激）を抑制することができる。
また、染毛剤組成物による毛髪へのダメージは、染料を浸透させるために行う毛髪の酸やアルカリ処理によって、毛髪のタンパク質が変性してしまうことに起因する。更に、ダメージを受けてキューティクルが開いた毛髪がそのままの状態で乾燥してしまうことにより、毛髪のダメージはより一層大きくなる。従来の染毛剤組成物の場合、カチオン性界面活性剤などの界面活性剤がキューティクルの隙間に入り込み吸着するため、キューティクルの開きが元に戻りにくくなり、毛髪がダメージを受けやすい。一方、本願発明の染毛剤組成物の場合、前記構造体が毛髪の表面に付着することにより、開いたキューティクルが元に戻りやすくなり、毛髪のダメージが軽減される。しかも、前記構造体は、カチオン性界面活性剤などの界面活性剤に比べ抱水力に優れており、付着することによって毛髪に潤いを与えるため、キューティクルが開いた状態のまま毛髪が乾燥することを抑制できる。その結果、毛髪へのダメージは軽減（つまり低刺激）される。また、これにより、毛髪内に侵入または毛髪に付着した染料がキューティクルの隙間から流失することも抑制されるため、染毛性が相乗的に向上するという利点もある。前記の機構により、本願発明の染毛剤組成物は、従来の染毛剤組成物に比べて、毛髪への刺激が低減するにもかかわらず、染毛性が向上すると考えられる。このような機構を図１に概略的に示した。
Although the mechanism in which the said effect is show | played is not specifically limited, It estimates as follows.
The structure has a structure in which an oil agent is surrounded by a closed hydrophilic endoplasmic reticulum or a polycondensation polymer particle, and is larger in size than a surfactant such as a dye or a cationic surfactant that is liberated as a molecule. Is big. Therefore, the moving speed of the structure is slower than that of a surfactant such as a dye or a cationic surfactant. Therefore, it is believed that many dyes can penetrate into or attach to the hair before the structure is attached to the cuticle. Therefore, the structure is unlikely to inhibit the penetration of the dye into the hair or the attachment to the hair. In addition, after the dye has entered or adhered to the hair, the structure adheres to the cuticle surface, thereby preventing the dye that has entered or adhered from being washed away. Thereby, since hair dyeing property improves, it becomes possible to finish hair dyeing efficiently in a short time, and to wash away a hair dye composition from hair. Therefore, since the time for the hair dye composition to contact the hair is shortened, damage to the hair (stimulation to the hair) can be suppressed.
Moreover, the damage to the hair by the hair dye composition is caused by denaturation of hair protein by acid or alkali treatment of the hair performed to penetrate the dye. Further, the hair that has been damaged and opened with the cuticle is dried as it is, so that the hair is further damaged. In the case of a conventional hair dye composition, a surfactant such as a cationic surfactant enters and adsorbs into the gap of the cuticle, so that the opening of the cuticle is difficult to return to the original, and the hair is easily damaged. On the other hand, in the case of the hair dye composition of the present invention, when the structure adheres to the surface of the hair, the opened cuticle is easily returned to the original, and hair damage is reduced. In addition, the structure is superior in water holding power compared to surfactants such as cationic surfactants, and moisturizes the hair by adhering to it, so that the hair dries with the cuticle open. Can be suppressed. As a result, damage to the hair is reduced (ie, low irritation). This also suppresses the dye that enters or adheres to the hair from flowing through the gaps in the cuticle, and thus has the advantage of synergistically improving hair dyeing properties. According to the above mechanism, the hair dye composition of the present invention is considered to improve the hair dyeing property although the irritation to the hair is reduced as compared with the conventional hair dye composition. Such a mechanism is shown schematically in FIG.
本発明の染毛剤組成物とは、毛髪などの体毛を染色することを目的として使用される組成物を意味する。具体的には、例えば、永久染毛剤（パーマネントヘアカラー）、半永久染毛料（セミパーマネントヘアカラー）、一時染毛料などが、本発明の染毛剤組成物に含まれる。また、パーティーなどで使用されるヘアカラースプレーなどの雑貨も、染色することを目的として使用される組成物であるため、本発明の染毛剤組成物に含まれる。中でも、本発明による前記作用効果が発揮されやすい点で、染料が毛髪内へと侵入する永久染毛剤または半永久染毛料が好ましい。 The hair dye composition of the present invention means a composition used for the purpose of dyeing body hair such as hair. Specifically, for example, permanent hair dye (permanent hair color), semi-permanent hair dye (semi-permanent hair color), temporary hair dye and the like are included in the hair dye composition of the present invention. In addition, miscellaneous goods such as hair color sprays used at parties and the like are compositions used for the purpose of dyeing, and are therefore included in the hair dye composition of the present invention. Especially, the permanent hair dye or semipermanent hair dye which a dye penetrate | invades into hair is preferable at the point which the said effect by this invention is easy to be exhibited.
エマルションとは、互いに混ざり合わない２相間で、一方が他方の相に粒子状に分散している分散系をいう。本願におけるエマルションとは、流動性が高いエマルション（例えば、ローション状、ミルク状などのエマルション）だけでなく、流動性が低いエマルション（例えば、クリーム状やゲル状などのエマルション）も含むものとする。なお、エマルションの流動性は高いことが多いが、水性成分や油剤の組成やその他の条件によっては、低くなる場合もある。 An emulsion refers to a dispersion system in which one phase is dispersed in the other phase between two phases that are not mixed with each other. The emulsion in the present application includes not only an emulsion having a high fluidity (for example, an emulsion such as a lotion or milk) but also an emulsion having a low fluidity (for example, an emulsion such as a cream or gel). In addition, although the fluidity | liquidity of an emulsion is high in many cases, it may become low depending on the composition of an aqueous component and an oil agent, and other conditions.
本発明の染毛剤組成物は、毛髪に使用されることが望ましいが、例えば、眉毛、すね毛など、毛髪以外の体毛にも使用することができる。また、本発明の染毛剤組成物は、ヒトに使用することが望ましいが、例えば、イヌ、ネコなど、ヒト以外の動物の体毛にも使用することができる。 The hair dye composition of the present invention is desirably used for hair, but can also be used for body hair other than hair, such as eyebrows and shank hair. The hair dye composition of the present invention is preferably used for humans, but can also be used for the hair of animals other than humans such as dogs and cats.
染毛剤組成物は、従来公知のように、そのタイプ、組成、使用方法に応じ、一剤または二剤以上であってよい。二剤以上である場合における本発明の染毛剤組成物では、前記構造体および水性成分が二剤以上の少なくともいずれか１剤に含まれていればよい（構造体および水性成分が含有される剤は、他の剤と組み合わされるか否かにかかわらず、染毛剤組成物に該当する）。ただし、本明細書における各成分の染毛剤組成物に対する含有量とは、二剤以上の合計量に対する含有量を指す。 As conventionally known, the hair dye composition may be one agent or two or more agents depending on the type, composition, and method of use. In the hair dye composition of the present invention in the case of two or more agents, the structure and the aqueous component may be contained in at least one agent of two or more agents (the structure and the aqueous component are contained). The agent corresponds to a hair dye composition regardless of whether it is combined with other agents). However, content with respect to the hair dye composition of each component in this specification refers to content with respect to the total amount of two or more agents.
構造体の含有量は、所望の染毛性向上の程度に応じて適宜調整すれば良く、特に制限されない。本願において「構造体の含量」とは、構造体の表面を包囲する自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体または水酸基を有する重縮合ポリマー粒子の含有量と、前記閉鎖小胞体または水酸基を有する重縮合ポリマー粒子に包囲されて内包される成分の含有量とを合計した含有量のことを意味する。なお、本願における「構造体の含有量」は特に限定されないが、具体的には、例えば、染毛剤組成物に対し０．０１質量％以上、０．０５質量％以上、０．１質量％以上、０．２質量％以上、０．５質量％以上であってよい。 The content of the structure may be appropriately adjusted according to the desired degree of hair dyeing improvement, and is not particularly limited. In the present application, the “content of the structure” means the content of the polycondensation polymer particles having a closed vesicle or a hydroxyl group formed by an amphiphile that spontaneously forms a closed vesicle surrounding the surface of the structure. Means the total content of the components enclosed and encapsulated in the closed endoplasmic reticulum or the polycondensation polymer particles having a hydroxyl group. The “content of the structure” in the present application is not particularly limited, and specifically, for example, 0.01% by mass or more, 0.05% by mass or more, and 0.1% by mass with respect to the hair dye composition. As mentioned above, it may be 0.2 mass% or more and 0.5 mass% or more.
本発明において構造体を含むエマルションを添加する場合、構造体を含むエマルションの含有量は、所望の染毛性向上の程度に応じて適宜調整すれば良く、特に制限されない。本願において「構造体を含むエマルションの含有量」とは、染毛剤組成物に添加する構造体を含むエマルションの染毛剤組成物に対する含有量のことであり、構造体および構造体の外側にある水性成分の含有量を合計した含有量のことを意味する。なお、本願における「構造体を含むエマルションの含有量」は特に限定されないが、具体的には、例えば、染毛剤組成物に対し０．０１質量％以上、０．０５質量％以上、０．１質量％以上、０．２質量％以上であってよい。 In the present invention, when an emulsion containing a structure is added, the content of the emulsion containing a structure may be appropriately adjusted according to the desired degree of hair dyeing improvement, and is not particularly limited. In the present application, the “content of the emulsion containing the structure” refers to the content of the emulsion containing the structure added to the hair dye composition with respect to the hair dye composition, and is outside the structure and the structure. It means the total content of certain aqueous components. In addition, the “content of the emulsion including the structure” in the present application is not particularly limited, but specifically, for example, 0.01% by mass or more, 0.05% by mass or more, 0.00% by mass with respect to the hair dye composition. It may be 1% by mass or more and 0.2% by mass or more.
油剤は、染毛剤組成物で使用可能な油剤であればよく、極性または非極性、常温（２０℃）において液体または固体であってよい。ただし、キューティクルを保護し、染毛性および低刺激性を実現しやすい点で、油剤は、抱水性油剤、または２０℃において固形である固形油を含有することが好ましい。抱水性油剤または固形油が構造体に包含される場合、毛髪の周囲に前記構造体が付着した後も、構造体は変形せずに、球状のままの立体的形状を保ちやすい。その結果、毛髪に付着した隣接する構造体同士の間に立体的な隙間が生じ、その隙間を通じて染料が毛髪内に侵入することが可能となる。そのため、抱水性油剤または固形油が構造体に含まれる場合、染毛剤組成物の染毛性が高まると考えられる。 The oil agent may be an oil agent that can be used in the hair dye composition, and may be polar or nonpolar and liquid or solid at room temperature (20 ° C.). However, it is preferable that the oil contains a water-holding oil or a solid oil that is solid at 20 ° C. in terms of protecting the cuticle and easily achieving hair dyeing and low irritation. In the case where a water-holding oil or solid oil is included in the structure, the structure does not deform even after the structure adheres to the periphery of the hair, and it is easy to maintain a three-dimensional shape that remains spherical. As a result, a three-dimensional gap is formed between adjacent structures attached to the hair, and the dye can enter the hair through the gap. Therefore, when a water-holding oil or solid oil is contained in the structure, it is considered that the hair dyeing property of the hair dye composition is enhanced.
抱水性油剤は、特に限定されないが、分子内に１以上の極性基を有し、常温で液体もしくはペースト状や固体の油溶性物質であってよい。例えば、イソステアリン酸、イソパルミチン酸、オレイン酸、パルミトレイン酸、リノール酸、リシノレイン酸などの脂肪酸、ラノリン、ラノリンアルコール、水素添加ラノリンアルコールなどのラノリン誘導体、セタノール、ヘキシルデカノール、ステアリルアルコール、オクチルドデカノール、オレイルアルコール、セトステアリルアルコール、ミリスチルアルコール、ベヘニルアルコールなどの高級アルコール、コレステロール誘導体およびフィトステロール誘導体などの動植物油由来の脂肪酸エステルおよび脂肪酸オリゴマーエステルが挙げられ、これらの１種または２種以上であってよい。前記コレステロール誘導体およびフィトステロール誘導体としては、マカデミアナッツ油脂肪酸コレステリル、マカデミアナッツ油脂肪酸フィトステリル、ラノリン脂肪酸コレステリル、１２−ヒドロキシステアリン酸コレステリルなどが挙げられる。 The water-holding oil agent is not particularly limited, and may be an oil-soluble substance that has one or more polar groups in the molecule and is liquid or pasty or solid at room temperature. For example, fatty acids such as isostearic acid, isopalmitic acid, oleic acid, palmitoleic acid, linoleic acid, ricinoleic acid, lanolin derivatives such as lanolin, lanolin alcohol, hydrogenated lanolin alcohol, cetanol, hexyldecanol, stearyl alcohol, octyldodecanol, oleyl Examples include higher alcohols such as alcohol, cetostearyl alcohol, myristyl alcohol, and behenyl alcohol, fatty acid esters and fatty acid oligomer esters derived from animal and vegetable oils such as cholesterol derivatives and phytosterol derivatives, and one or more of these may be used. Examples of the cholesterol derivative and phytosterol derivative include macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, lanolin fatty acid cholesteryl, and cholesteryl 12-hydroxystearate.
本願において、「２０℃において固形である固形油」とは、２０℃において流動性がない油のことを意味する。「２０℃において固形である固形油」としては、２０℃において流動性がない、炭化水素、ロウ、硬化油、高級脂肪酸、高級アルコール、エステル類、シリコーン類、水添植物油などが使用できる。具体的には、パラフィンワックス、ワセリン、ミツロウ、ステアリン酸、ミリスチン酸、セチルアルコール、ステアリルアルコール、ベヘニルアルコール、ヒドロキシステアリン酸コレステリルなどのコレステロール脂肪酸エステル、マカデミアンナッツ油脂肪酸フィトステリルなどのフィトステロール脂肪酸エステル、水添ホホバ油などが挙げられる。 In the present application, “solid oil that is solid at 20 ° C.” means oil that does not flow at 20 ° C. Examples of the “solid oil that is solid at 20 ° C.” include hydrocarbons, waxes, hardened oils, higher fatty acids, higher alcohols, esters, silicones, hydrogenated vegetable oils, and the like that do not flow at 20 ° C. Specifically, paraffin wax, petrolatum, beeswax, stearic acid, myristic acid, cetyl alcohol, stearyl alcohol, behenyl alcohol, cholesterol fatty acid esters such as cholesteryl hydroxystearate, phytosterol fatty acid esters such as macadamian nut oil fatty acid phytosteryl, hydrogenated Jojoba oil.
油剤の含有量は、染毛剤組成物に対して０．００１質量％以上、０．０１質量％以上、０．１質量％以上、０．５質量％以上、１質量％以上であってもよく、３０質量％以下、２０質量％以下、１５質量％以下、１０質量％以下、５質量％以下であってもよい。 Even if content of oil agent is 0.001 mass% or more, 0.01 mass% or more, 0.1 mass% or more, 0.5 mass% or more, 1 mass% or more with respect to the hair dye composition. It may be 30% by mass or less, 20% by mass or less, 15% by mass or less, 10% by mass or less, and 5% by mass or less.
水性成分は、精製水、温泉水、深層水、または植物などの水蒸気蒸留水などの水、もしくは水と親和性のある溶媒であれば特に限定されず、例えばグリセリン、１，３−ブチレングリコールなどの多価アルコール、エチルアルコールなどの低級アルコールなどが例示され、これらの１種または２種以上が用いられる。 The aqueous component is not particularly limited as long as it is water such as purified water, hot spring water, deep layer water, steam distilled water such as plants, or a solvent that is compatible with water. For example, glycerin, 1,3-butylene glycol, etc. And lower alcohols such as ethyl alcohol, and one or more of these are used.
染料は、Ｏ／Ｗ型エマルションの任意の箇所に含まれてよいが、染料の少なくとも一部は、前記構造体の外側に位置することが好ましい。 The dye may be contained in any part of the O / W emulsion, but at least a part of the dye is preferably located outside the structure.
染料は、染毛剤組成物で使用可能な染料であればよく、染毛剤組成物のタイプに応じ適宜選択されてよい。
例えば、永久染毛剤においては、５−アミノオルトクレゾール、２−アミノ−４−ニトロフェノール、２−アミノ−５−ニトロフェノール、１−アミノ−４−メチルアミノアントラキノン、３，３’−イミノジフェノール、塩酸２，４−ジアミノフェノキシエタノール、塩酸２，４−ジアミノフェノール、塩酸トルエン−２，５−ジアミン、塩酸ニトロパラフェニレンジアミン、塩酸パラフェニレンジアミン、塩酸Ｎ−フェニルパラフェニレンジアミン、塩酸メタフェニレンジアミン、オルトアミノフェノール、酢酸Ｎ−フェニルパラフェニレンジアミン、１，４−ジアミノアントラキノン、２，６−ジアミノピリジン、１，５−ジヒドロキシナフタレン、トルエン−２，５−ジアミン、トルエン−３，４−ジアミン、ニトロパラフェニレンジアミン、パラアミノフェノール、パラニトロオルトフェニレンジアミン、パラフェニレンジアミン、パラメチルアミノフェノール、ピクラミン酸、ピクラミン酸ナトリウム、Ｎ，Ｎ’−ビス（４−アミノフェニル）−２，５−ジアミノ−１，４−キノンジイミン、５−（２−ヒドロキシエチルアミノ）−２−メチルフェノール、Ｎ−フェニルパラフェニレンジアミン、メタアミノフェノール、メタフェニレンジアミン、硫酸５−アミノオルトクレゾール、硫酸２−アミノ−５−ニトロフェノール、硫酸オルトアミノフェノール、硫酸オルトクロルパラフェニレンジアミン、硫酸４，４’−ジアミノジフェニルアミン、硫酸２，４−ジアミノフェノール、硫酸トルエン−２，５−ジアミン、硫酸ニトロパラフェニレンジアミン、硫酸パラアミノフェノール、硫酸パラニトロオルトフェニレンジアミン、硫酸パラニトロメタフェニレンジアミン、硫酸パラフェニレンジアミン、硫酸パラメチルアミノフェノ−ル、硫酸メタアミノフェノール、硫酸メタフェニレンジアミンなどの１種以上と、カテコ−ル、ジフェニルアミン、α−ナフトール、ヒドロキノン、ピロガロール、フロログルシン、没食子酸、レゾルシンなどの１種以上と、の組合せが挙げられる。
例えば、染毛料（半永久染毛料または一時染毛料）においては、２−ニトロパラフェニレンジアミン、４−ニトロオルトフェニレンジアミン、ＨＣ赤３、ＨＣ黄２、ＨＣ黄４、ＨＣ青１、ＨＣ赤１、ＨＣ橙１、酸性橙３などの１種以上が挙げられる。
The dye may be any dye that can be used in the hair dye composition, and may be appropriately selected according to the type of the hair dye composition.
For example, in permanent hair dyes, 5-aminoorthocresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3′-iminodi Phenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene-2,5-diamine hydrochloride, nitroparaphenylenediamine hydrochloride, paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride , Orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5-dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, Nitroparaphenylene di Amine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picramate, N, N′-bis (4-aminophenyl) -2,5-diamino-1,4- Quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, metaphenylenediamine, 5-aminoorcresol sulfate, 2-amino-5-nitrophenol sulfate, sulfuric acid Orthoaminophenol, orthochloroparaphenylenediamine sulfate, 4,4′-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, nitroparaphenylenediamine sulfate, paraaminophenol sulfate At least one of diol, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine sulfate, catechol, diphenylamine , Α-naphthol, hydroquinone, pyrogallol, phloroglucin, gallic acid, resorcin and the like.
For example, in hair dyes (semi-permanent hair dyes or temporary hair dyes), 2-nitroparaphenylenediamine, 4-nitroorthophenylenediamine, HC red 3, HC yellow 2, HC yellow 4, HC blue 1, HC red 1, 1 or more types, such as HC orange 1 and acidic orange 3, are mentioned.
染料の含有量は、特に限定されず、染毛剤組成物に対して０．０１質量％以上、０．１質量％以上、０．５質量％以上、１質量％以上であってもよく、５質量％以下、３質量％以下、２質量％以下、１質量％以下であってもよい。ただし、本発明の染毛剤組成物は染毛性に優れるため、過剰量の染料を用いなくてもよいため、染料の含有量は、染毛剤組成物に対して１〜２質量％であってよい。 The content of the dye is not particularly limited, and may be 0.01% by mass or more, 0.1% by mass or more, 0.5% by mass or more, 1% by mass or more with respect to the hair dye composition, 5 mass% or less, 3 mass% or less, 2 mass% or less, and 1 mass% or less may be sufficient. However, since the hair dye composition of the present invention is excellent in hair dyeing properties, it is not necessary to use an excessive amount of dye, so the dye content is 1 to 2% by mass with respect to the hair dye composition. It may be.
水性成分の含有量は、染毛剤組成物に対して７０〜９９．９９質量％であってよい。 Content of an aqueous component may be 70-99.99 mass% with respect to the hair dye composition.
閉鎖小胞体および重縮合ポリマー粒子は、エマルション形成前では平均粒子径８ｎｍ〜８００ｎｍ程度であるが、Ｏ／Ｗ型エマルション構造においては平均粒子径８ｎｍ〜５００ｎｍ程度である。なお、両親媒性物質の閉鎖小胞体および水酸基を有する重縮合ポリマーの粒子は、一方のみが含まれても、双方が含まれてもよい。双方が含まれる場合には、例えば、別々に乳化したエマルションを混合してよい。 The closed endoplasmic reticulum and the polycondensation polymer particles have an average particle size of about 8 nm to 800 nm before the formation of the emulsion, but have an average particle size of about 8 nm to 500 nm in the O / W emulsion structure. Note that only one or both of the amphiphilic substance closed endoplasmic reticulum and the polycondensation polymer particles having a hydroxyl group may be contained. When both are included, for example, separately emulsified emulsions may be mixed.
自発的に閉鎖小胞体を形成する両親媒性物質としては、特に限定されないが、リン脂質やリン脂質誘導体など、ポリグリセリン脂肪酸エステルなど、特に疎水基と親水基とがエステル結合したものを採用してもよい。また、刺激緩和性に優れる点で、ジラウロイルグルタミン酸リシンＮａも好ましい。 The amphipathic substance that spontaneously forms a closed endoplasmic reticulum is not particularly limited, but phospholipids and phospholipid derivatives, polyglycerin fatty acid esters, etc., particularly those in which a hydrophobic group and a hydrophilic group are ester-bonded are employed. May be. Moreover, dilauroyl glutamic acid lysine Na is also preferable in terms of excellent stimulus relaxation properties.
リン脂質としては、下記の一般式１で示される構成のうち、炭素鎖長１２のＤＬＰＣ（１，２−Ｄｉｌａｕｒｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｃｈｏｌｉｎｅ）、炭素鎖長１４のＤＭＰＣ（１，２−Ｄｉｍｙｒｉｓｔｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｃｈｏｌｉｎｅ）、炭素鎖長１６のＤＰＰＣ（１，２−Ｄｉｐａｌｍｉｔｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｃｈｏｌｉｎｅ）が採用可能である。 As the phospholipid, among the structures represented by the following general formula 1, DLPC (1,2-Dilauroyl-sn-glycero-3-phospho-rac-1-choline) having a carbon chain length of 12, DMPC (1,2-Dimyristol-sn-glycero-3-phospho-rac-1-choline), DPPC with a carbon chain length of 16 (1,2-Dipalmitoyyl-sn-glycero-3-phospho-rac-1-choline) Can be adopted.
一般式１
また、下記の一般式２で示される構成のうち、炭素鎖長１２のＤＬＰＧ（１，２−Ｄｉｌａｕｒｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｇｌｙｃｅｒｏｌ）のＮａ塩またはＮＨ４塩、炭素鎖長１４のＤＭＰＧ（１，２−Ｄｉｍｙｒｉｓｔｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｇｌｙｃｅｒｏｌ）のＮａ塩またはＮＨ４塩、炭素鎖長１６のＤＰＰＧ（１，２−Ｄｉｐａｌｍｉｔｏｙｌ−ｓｎ−ｇｌｙｃｅｒｏ−３−ｐｈｏｓｐｈｏ−ｒａｃ−１−ｇｌｙｃｅｒｏｌ）のＮａ塩またはＮＨ４塩を採用してもよい。 In addition, among the structures represented by the following general formula 2, Na salt or NH4 salt of carbon chain length 12 DLPG (1,2-Diilauroyl-sn-glycero-3-phospho-rac-1-glycerol), carbon chain Na or NH4 salt of DMPG having a length of 14 (1,2-Dimyristol-sn-glycero-3-phospho-rac-1-glycerol), DPPG having a carbon chain length of 16 (1,2-Dipalmitoyyl-sn-glycero-3) -Phospho-rac-1-glycerol) Na salt or NH4 salt may be employed.
一般式２
更に、リン脂質として卵黄レシチンまたは大豆レシチンなどのレシチンまたはそれを水素化したものを採用してもよい。 Further, lecithin such as egg yolk lecithin or soybean lecithin or a hydrogenated version thereof may be employed as the phospholipid.
ポリグリセリン脂肪酸エステルとしては、ポリグリセリンと直鎖脂肪酸または分岐脂肪酸のエステルであり、具体的には、モノパルミチン酸ポリグリセリル、ジパルミチン酸ポリグリセリル、トリパルミチン酸ポリグリセリル、モノステアリン酸ポリグリセリル、ジステアリン酸ポリグリセリル、トリステアリン酸ポリグリセリル、モノイソステアリン酸ポリグリセリル、ジイソステアリン酸ポリグリセリル、トリイソステアリン酸ポリグリセリルなどが挙げられる。 The polyglycerin fatty acid ester is an ester of polyglycerin and linear fatty acid or branched fatty acid, specifically, polyglyceryl monopalmitate, polyglyceryl dipalmitate, polyglyceryl tripalmitate, polyglyceryl monostearate, polyglyceryl distearate, Examples thereof include polyglyceryl tristearate, polyglyceryl monoisostearate, polyglyceryl diisostearate, polyglyceryl triisostearate and the like.
また、両親媒性物質として、下記の一般式３で表されるポリオキシエチレン硬化ひまし油の誘導体、もしくは一般式４で表されるジアルキルアンモニウム誘導体、トリアルキルアンモニウム誘導体、テトラアルキルアンモニウム誘導体、ジアルケニルアンモニウム誘導体、トリアルケニルアンモニウム誘導体、またはテトラアルケニルアンモニウム誘導体のハロゲン塩の誘導体を採用しても良い。 Further, as an amphiphilic substance, a polyoxyethylene hydrogenated castor oil derivative represented by the following general formula 3, or a dialkyl ammonium derivative, a trialkyl ammonium derivative, a tetraalkyl ammonium derivative, a dialkenyl ammonium represented by the general formula 4 A derivative, a trialkenyl ammonium derivative, or a halogen salt derivative of a tetraalkenyl ammonium derivative may be employed.
一般式３
式中、エチレンオキシドの平均付加モル数であるＥは、３〜１００である。Ｅが過大になると、両親媒性物質を溶解する良溶媒の種類が制限されるため、親水性ナノ粒子の製造の自由度が狭まる。Ｅの上限は好ましくは５０であり、より好ましくは４０であり、Ｅの下限は好ましくは５である。 In the formula, E, which is the average added mole number of ethylene oxide, is 3 to 100. If E is excessive, the type of good solvent that dissolves the amphiphilic substance is limited, and thus the degree of freedom in producing hydrophilic nanoparticles is narrowed. The upper limit of E is preferably 50, more preferably 40, and the lower limit of E is preferably 5.
一般式４
式中、Ｒ１およびＲ２は、各々独立して炭素数８〜２２のアルキル基またはアルケニル基であり、Ｒ３およびＲ４は、各々独立して水素または炭素数１〜４のアルキル基であり、ＸはＦ、Ｃｌ、Ｂｒ、ＩまたはＣＨ３ＣＯＯである。 In the formula, R 1 and R 2 are each independently an alkyl group or alkenyl group having 8 to 22 carbon atoms, R 3 and R 4 are each independently hydrogen or an alkyl group having 1 to 4 carbon atoms, and X is F, Cl, Br, I or CH3COO.
水酸基を有する重縮合ポリマーは、天然高分子又は合成高分子のいずれであってもよく、乳化剤の用途に応じて適宜選択されてよい。ただし、安全性に優れ、一般的に安価である点で、天然高分子が好ましく、乳化機能に優れる点で以下に述べる糖ポリマーがより好ましい。なお、粒子とは、重縮合ポリマーが単粒子化したもの、又はその単粒子同士が連なったもののいずれも包含する一方、単粒子化される前の凝集体（網目構造を有する）は包含しない。 The polycondensation polymer having a hydroxyl group may be either a natural polymer or a synthetic polymer, and may be appropriately selected according to the use of the emulsifier. However, natural polymers are preferable from the viewpoint of safety and generally inexpensive, and sugar polymers described below are more preferable from the viewpoint of excellent emulsifying function. In addition, while the particle | grain includes both the thing which the polycondensation polymer was made into the single particle, or the thing with which the single particle connected, on the other hand, the aggregate (it has a network structure) before making into a single particle is not included.
糖ポリマーは、セルロース、デンプンなどのグルコシド構造を有するポリマーである。例えば、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルメチルセルロース誘導体、スルホン化セルロース誘導体などの合成高分子が挙げられる。 The sugar polymer is a polymer having a glucoside structure such as cellulose and starch. For example, synthetic polymers such as hydroxypropylmethylcellulose, hydroxypropylmethylcellulose derivatives, sulfonated cellulose derivatives and the like can be mentioned.
また、水酸基を有する重縮合ポリマーは、カチオン性の重縮合ポリマーであっても良い。カチオン性の重縮合ポリマーは、特に限定されないが、例えば、グアーヒドロキシプロピルトリモニウムクロリドなどのカチオン化グアーガム、ヒドロキシエチルセルロースヒドロキシプロピルトリメチルアンモニウムクロリドエーテルなどのカチオン化セルロースなどが挙げられる。 The polycondensation polymer having a hydroxyl group may be a cationic polycondensation polymer. The cationic polycondensation polymer is not particularly limited, and examples thereof include cationic guar gum such as guar hydroxypropyltrimonium chloride, and cationic cellulose such as hydroxyethylcellulose hydroxypropyltrimethylammonium chloride ether.
本発明の染毛剤組成物は、更に界面活性剤を含有することができる。界面活性剤は、本発明の染毛剤組成物が、前記構造体中の油剤以外の油性成分を含有する場合に、この油性成分を乳化するために特に有用である。界面活性剤は、染毛剤組成物に含有される水性成分と油性成分（含有される場合）とを乳化させる機能を有する。また、キューティクルの隙間に入り込み吸着して、キューティクルの開きを大きくすることにより、染料を毛髪内に侵入または毛髪へ付着しやすくする機能を有する。他方、従来の染毛剤組成物は、界面活性剤がキューティクルを過剰に開かせてしまいやすく、また、過剰に開いたキューティクルがもとに戻ることを妨げるため、刺激性が高いという問題を有する。一方、本願発明の染毛剤組成物は、前記のように、前記構造体によってキューティクルの過剰な開きが抑制させるため、従来の染毛剤組成物が有する界面活性剤によるデメリットを抑えることができる。このため、本発明で用いられる界面活性剤は、染料の侵入または付着の促進機能に優れるカチオン性界面活性剤を含むことが好ましい。 The hair dye composition of the present invention may further contain a surfactant. The surfactant is particularly useful for emulsifying the oily component when the hair dye composition of the present invention contains an oily component other than the oil in the structure. The surfactant has a function of emulsifying the aqueous component and the oily component (if contained) contained in the hair dye composition. In addition, it has a function of facilitating the penetration of the dye into the hair or adhering to the hair by entering and adsorbing into the gap of the cuticle to increase the opening of the cuticle. On the other hand, the conventional hair dye composition has a problem that it is highly irritating because the surfactant tends to open the cuticle excessively and prevents the cuticle from opening excessively. . On the other hand, since the hair dye composition of the present invention suppresses the excessive opening of the cuticle by the structure as described above, it is possible to suppress the disadvantages caused by the surfactant of the conventional hair dye composition. . For this reason, it is preferable that the surfactant used in the present invention includes a cationic surfactant that is excellent in the function of promoting dye penetration or adhesion.
カチオン性界面活性剤としては、特に限定されないが、塩化ラウリルトリメチルアンモニウム、塩化セチルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム（ステアリルトリモニウムクロリド）、塩化アルキルトリメチルアンモニウム、塩化ベヘニルトリメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、臭化セチルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、エチル硫酸ラノリン脂肪酸アミノプロピルエチルジメチルアンモニウム、ステアリルトリメチルアンモニウムサッカリン、セチルトリメチルアンモニウムサッカリン、塩化メタクリロイルオキシエチルトリメチルアンモニウム、メチル硫酸ベヘニルトリメチルアンモニウム、ポリクオタニウム−７などの１種以上が挙げられる。 The cationic surfactant is not particularly limited, but lauryltrimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride (stearyltrimonium chloride), alkyltrimethylammonium chloride, behenyltrimethylammonium chloride, distearyldimethylammonium chloride, Such as cetyltrimethylammonium bromide, stearyltrimethylammonium bromide, ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium, stearyltrimethylammonium saccharin, cetyltrimethylammonium saccharin, methacryloyloxyethyltrimethylammonium chloride, behenyltrimethylammonium methylsulfate, polyquaternium-7 One or more
本発明で用いられる界面活性剤は、カチオン性界面活性剤とともにまたはカチオン性界面活性剤を含まずに、アニオン性界面活性剤、両性界面活性剤またはノニオン性界面活性剤を含んでもよい。 The surfactant used in the present invention may contain an anionic surfactant, an amphoteric surfactant or a nonionic surfactant with or without a cationic surfactant.
アニオン性界面活性剤としては、アルキル（またはアルケニル）硫酸塩、ポリオキシアルキレンアルキル（またはアルケニル）エーテル硫酸塩、アルカンスルホン酸塩、オレフィンスルホン酸塩、アルキルベンゼンスルホン酸塩、アルキル（またはアルケニル）スルホコハク酸塩、ジアルキル（またはジアルケニル）スルホコハク酸塩、ポリオキシアルキレンアルキル（またはアルケニル）スルホコハク酸塩、アルキル（またはアルケニル）エーテルカルボン酸塩、ポリオキシアルキレンアルキル（またはアルケニル）エーテルカルボン酸塩、ポリオキシアルキレンアルキル（またはアルケニル）エーテルリン酸塩、脂肪酸塩、Ｎ−アシルグルタミン酸塩、Ｎ−アシルタウリン酸塩、Ｎ−アシルメチルタウリンなどの１種以上が挙げられる。 Anionic surfactants include alkyl (or alkenyl) sulfate, polyoxyalkylene alkyl (or alkenyl) ether sulfate, alkane sulfonate, olefin sulfonate, alkyl benzene sulfonate, alkyl (or alkenyl) sulfosuccinic acid Salt, dialkyl (or dialkenyl) sulfosuccinate, polyoxyalkylene alkyl (or alkenyl) sulfosuccinate, alkyl (or alkenyl) ether carboxylate, polyoxyalkylene alkyl (or alkenyl) ether carboxylate, polyoxyalkylene alkyl (Or alkenyl) ether phosphates, fatty acid salts, N-acyl glutamates, N-acyl taurates, N-acyl methyl taurines and the like.
両性界面活性剤としては、ココベタイン、ラウラミドプロピルベタイン、コカミドプロピルベタイン、ラウロアンホ酢酸ナトリウム、ココアンホ酢酸ナトリウム、およびラウリルベタイン（ラウリルジメチルアミノ酢酸ベタイン）などの１種以上が挙げられる。 Examples of amphoteric surfactants include one or more of cocobetaine, lauramidopropyl betaine, cocamidopropyl betaine, sodium lauroamphoacetate, sodium cocoamphoacetate, and laurylbetaine (lauryldimethylaminoacetic acid betaine).
ノニオン性界面活性剤としては、ポリオキシエチレンアルキルエーテル、ポリオキシプロピレンアルキルエーテル、高級脂肪酸ショ糖エステル、ポリグリセリン脂肪酸エステル、高級脂肪酸モノまたはジエタノールアミド、ポリオキシエチレン硬化ヒマシ油、ソルビタン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、アルキルポリグリコシド、アルキルアミンオキサイド、アルキルアミドアミンオキサイドなどの１種以上が挙げられる。 Nonionic surfactants include polyoxyethylene alkyl ethers, polyoxypropylene alkyl ethers, higher fatty acid sucrose esters, polyglycerin fatty acid esters, higher fatty acid mono- or diethanolamides, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, poly One or more of oxyethylene sorbitan fatty acid ester, polyoxyethylene sorbite fatty acid ester, alkyl polyglycoside, alkylamine oxide, alkylamidoamine oxide and the like can be mentioned.
ただし、本発明の染毛剤組成物では、閉鎖小胞体または重縮合ポリマー粒子が優れた乳化性能を有するので、界面活性剤を更に含有しなくてもよい。本発明の染毛剤組成物では、閉鎖小胞体または重縮合ポリマー粒子が、前記構造体中の油剤以外の油性成分も乳化する機能があるため、界面活性剤を含有する必要性が小さい。 However, in the hair dye composition of the present invention, the closed endoplasmic reticulum or the polycondensation polymer particles have an excellent emulsifying performance, and therefore may not further contain a surfactant. In the hair dye composition of the present invention, the closed endoplasmic reticulum or the polycondensation polymer particles have a function of emulsifying oil components other than the oil agent in the structure, and therefore it is less necessary to contain a surfactant.
本発明の染毛剤組成物が界面活性剤（特にカチオン性界面活性剤）を含有しない場合には、特に、閉鎖小胞体を構成する両親媒性物質、または重縮合ポリマー粒子を構成する重縮合ポリマーがカチオン性であることが好ましい。これにより、前記構造体から離脱した閉鎖小胞体または重縮合ポリマー粒子が、毛髪のキューティクルの隙間に入り込み吸着して、染料の毛髪内への侵入または毛髪への付着を一層促進するため、界面活性剤不含であっても、優れた染毛性能を有する染毛剤組成物を提供することができる。 When the hair dye composition of the present invention does not contain a surfactant (particularly a cationic surfactant), in particular, an amphiphile constituting a closed endoplasmic reticulum, or a polycondensation constituting a polycondensation polymer particle. It is preferred that the polymer is cationic. As a result, the closed endoplasmic reticulum or the polycondensation polymer particles detached from the structure enter the gaps in the hair cuticle and adsorb, thereby further promoting the penetration of the dye into the hair or the attachment to the hair. A hair dye composition having excellent hair dyeing performance can be provided even without the agent.
両親媒性物質のカチオン化は、両親媒性物質を、カチオン性界面活性剤などにより処理することで行うことができる。より具体的には以下のような方法が採用できる。 Cationization of the amphiphile can be performed by treating the amphiphile with a cationic surfactant or the like. More specifically, the following method can be employed.
両親媒性物質として公知のポリオキシエチレン硬化ヒマシ油（ＨＣＯ−Ｘ：Ｘは１０〜１００）をカチオン界面活性剤（ＣＴＡＢセチルトリメチルアンモニウムブロマイドなど)でカチオン化する場合、ＨＣＯ−Ｘと炭素数１４以上の前記カチオン界面活性剤をモル分率Ｘｓ＝０．１以下になるように混合・撹拌した後、ＨＣＯ−Ｘが所定の濃度になるように蒸留水を加え撹拌することでカチオン化された閉鎖小胞体を得ることができる。カチオン界面活性剤をモル分率０．１以上添加しても、閉鎖小胞体のζ電位はそれ以上変化しないで、カチオン界面活性剤が閉鎖小胞体中に可溶化するだけでなく、水中に溶出する可能性があるので、モル分率０．１が最も良いと考えられる。 When polyoxyethylene hydrogenated castor oil (HCO-X: X is 10 to 100) known as an amphiphilic substance is cationized with a cationic surfactant (CTAB cetyltrimethylammonium bromide or the like), HCO-X and carbon number 14 After mixing and stirring the above cationic surfactant so that the molar fraction Xs was 0.1 or less, it was cationized by adding distilled water and stirring so that HCO-X had a predetermined concentration. A closed endoplasmic reticulum can be obtained. Even when a cationic surfactant is added in a molar fraction of 0.1 or more, the zeta potential of the closed endoplasmic reticulum does not change any more, and the cationic surfactant is not only solubilized in the closed endoplasmic reticulum but also eluted in water. Therefore, a molar fraction of 0.1 is considered the best.
閉鎖小胞体を形成する物質をリン脂質に変えたときも、カチオン化閉鎖小胞体の調製方法は同様である。しかし、リン脂質の場合、カチオン界面活性剤の可溶化に時間がかかることがあるので、下記の混合結晶を作成してから水に添加する方法にて調製してもよい。リン脂質にエタノールなどの良溶媒を加えＶｏｒｔｅｘで撹拌し、均一に溶解させる。一方でカチオン界面活性剤もまた同様にエタノール溶液を調製する。リン脂質／エタノール溶液およびカチオン界面活性剤／エタノール溶液をそれぞれ所定の混合組成になるように混合し、十分撹拌する。乾燥によりエタノールを完全に除去しリン脂質とカチオン界面活性剤の混合固体を作製する。次に、この混合結晶にリン脂質が所定の濃度となるように水を加え、分散することでカチオン化された閉鎖小胞体を得ることができる。 The method for preparing the cationized closed endoplasmic reticulum is the same when the substance forming the closed endoplasmic reticulum is changed to phospholipid. However, in the case of phospholipids, it may take time to solubilize the cationic surfactant. Therefore, the following mixed crystals may be prepared and then added to water. A good solvent such as ethanol is added to the phospholipid and stirred with Vortex to dissolve it uniformly. On the other hand, an ethanol solution is similarly prepared for the cationic surfactant. The phospholipid / ethanol solution and the cationic surfactant / ethanol solution are mixed so as to have a predetermined mixed composition and stirred sufficiently. Ethanol is completely removed by drying to produce a mixed solid of phospholipid and cationic surfactant. Next, cationized closed endoplasmic reticulum can be obtained by adding water to the mixed crystal so that the phospholipid has a predetermined concentration and dispersing it.
本発明の染毛剤組成物は、前記構造体中の油剤の他に、油性成分を更に含有してもよい。油性成分としては、例えば油脂（オリーブ油、ツバキ油、シア脂、アーモンド油、サフラワー油、ヒマワリ油、大豆油、綿実油、ゴマ油、トウモロコシ油、ナタネ油、コメヌカ油、コメ胚芽油、ブドウ種子油、アボカド油、マカダミアナッツ油、ヒマシ油、ヤシ油、および月見草油など）、ロウ、炭化水素（ミネラルオイル、パラフィン、流動パラフィン、軽質流動イソパラフィン、オレフィンオリゴマー、ポリイソブテン、水添ポリイソブテン、スクワラン、ポリブテン、ポリエチレン、マイクロクリスタリンワックス、およびワセリンなど）、アルキルグリセリルエーテル、エステル、およびシリコーンなどが挙げられる。 The hair dye composition of the present invention may further contain an oil component in addition to the oil agent in the structure. Examples of oil components include oils and fats (olive oil, camellia oil, shea fat, almond oil, safflower oil, sunflower oil, soybean oil, cottonseed oil, sesame oil, corn oil, rapeseed oil, rice bran oil, rice germ oil, grape seed oil, Avocado oil, macadamia nut oil, castor oil, palm oil, evening primrose oil, etc., wax, hydrocarbon (mineral oil, paraffin, liquid paraffin, light liquid isoparaffin, olefin oligomer, polyisobutene, hydrogenated polyisobutene, squalane, polybutene, polyethylene , Microcrystalline wax, petrolatum, etc.), alkyl glyceryl ethers, esters, and silicones.
ただし、本発明の染毛剤組成物は、前記構造体中の油剤の他に、油性成分を更に含有しなくてもよい。この場合、水性成分は、その少なくとも一部がゲル状態であってもよい。染毛剤組成物のゲル状水性成分の調製手段は、従来公知である（例えば、特許４０８０４４４号公報）ため、省略する。 However, the hair dye composition of the present invention may not further contain an oil component in addition to the oil agent in the structure. In this case, at least a part of the aqueous component may be in a gel state. Since the preparation means of the gel-like aqueous component of a hair dye composition is conventionally well-known (for example, patent 4080444), it abbreviate | omits.
本発明の染毛剤組成物は、そのタイプ、剤型などに応じ、アルカリ剤、酸化剤、水溶性高分子、高級アルコール、多価アルコール、糖類、防腐剤、キレート剤、安定剤、ｐＨ調整剤、植物抽出物、生薬抽出物、ビタミン類、香料、紫外線吸収剤、酸化助剤など、従来公知の成分を更に含有してもよい。詳細は省略する。 The hair dye composition of the present invention comprises an alkali agent, an oxidizing agent, a water-soluble polymer, a higher alcohol, a polyhydric alcohol, a saccharide, a preservative, a chelating agent, a stabilizer, and pH adjustment according to the type and dosage form. Conventionally known components such as agents, plant extracts, herbal extracts, vitamins, fragrances, ultraviolet absorbers, and oxidation aids may be further contained. Details are omitted.
本発明の染毛剤組成物は、毛髪などの体毛への染毛に広く使用することができる。前記のように、本発明の染毛剤組成物は、前記構造体が毛髪の表面に付着することにより、開いたキューティクルを元に戻しやすいことから、キューティクルが開き、毛髪に侵入または付着した染料が流失しやすいダメージ毛に好適に使用されることができる。なお、ダメージ毛とは、パーマネントウエーブ処理、脱色処理、染毛処理の１以上を受けた毛髪部分を指す。 The hair dye composition of the present invention can be widely used for dyeing hair such as hair. As described above, the hair dye composition of the present invention can easily return the opened cuticle by attaching the structure to the surface of the hair, so that the cuticle opens and the dye penetrates or adheres to the hair. Can be suitably used for damaged hair that is easily washed away. In addition, damaged hair refers to the hair part which received one or more of the permanent wave process, the decoloring process, and the hair dyeing process.
ただし、本発明の染毛剤組成物は、界面活性剤がキューティクルの隙間に入り込んだまま乾燥してダメージを蓄積させる従来の染毛剤組成物と異なり、毛髪に対して低刺激であるから、非ダメージ毛に用い、ダメージ化の予防に用いることもできる。 However, since the hair dye composition of the present invention is less irritating to the hair, unlike the conventional hair dye composition in which the surfactant is dried while remaining in the cuticle gap to accumulate damage, It can be used for non-damaged hair to prevent damage.
本発明の染毛剤組成物は、特許３８５５２０３号公報などを参照し、適宜調製することができる。例えば、両親媒性物質の二分子膜の層状体を水に分散させ、または水酸基を有する重縮合ポリマーを水中に単粒子化させ、両親媒性物質により形成された閉鎖小胞体または重縮合ポリマーの粒子を含む乳化剤分散液を形成する工程と、乳化剤分散液および油剤を混合することでＯ／Ｗ型エマルションを形成する工程と、を経て、前記構造体を作製することができる。次に、この構造体を、水性成分、および油性成分などの任意成分（構造体と混合する前に、各成分が界面活性剤で乳化されていてもよい）と混合し、染毛剤組成物を調製することができる。染料の添加は、構造体と水性成分との混合前または後のいずれで行ってもよい。 The hair dye composition of the present invention can be appropriately prepared with reference to Japanese Patent No. 3855203. For example, a layered body of a bilayer membrane of an amphiphile is dispersed in water, or a polycondensation polymer having a hydroxyl group is made into single particles in water, and a closed endoplasmic reticulum or polycondensation polymer formed of an amphiphile is formed. The structure can be produced through a step of forming an emulsifier dispersion containing particles and a step of forming an O / W emulsion by mixing the emulsifier dispersion and oil. Next, this structure is mixed with an optional component such as an aqueous component and an oil component (each component may be emulsified with a surfactant before mixing with the structure), and a hair dye composition Can be prepared. The addition of the dye may be performed either before or after mixing the structure and the aqueous component.
＜半永久染毛料の調製＞
水、ステアリルアルコール、ミネラルオイル、ミリスチルアルコール、ステアリルトリモニウムクロリド、ポリクオタニウム−７、ヒドロキシエチルセルロース、並びに、染料として塩基性茶１６、塩基性青９９、ＨＣ黄２、ＨＣ青２、およびＨＣ黄４を適量ずつ撹拌し、Ｏ／Ｗ型エマルションの半永久染毛料（染毛剤組成物）を調製した。
<Preparation of semi-permanent hair dye>
Water, stearyl alcohol, mineral oil, myristyl alcohol, stearyltrimonium chloride, polyquaternium-7, hydroxyethylcellulose, and basic tea 16, basic blue 99, HC yellow 2, HC blue 2, and HC yellow 4 as dyes An appropriate amount was stirred to prepare an O / W emulsion semi-permanent hair dye (hair dye composition).
＜構造体を含むエマルションの調製＞
水にレシチン（両親媒性物質）を加えて撹拌し、両親媒性物質により形成された閉鎖小胞体の分散液を調製した。この分散液にセタノール（抱水性油剤）を加えて撹拌し、レシチンの閉鎖小胞体によってセタノールを包囲させて乳化することにより、構造体を含むＯ／Ｗ型エマルションを調製した。各成分の配合量は、表１に示すとおりである。なお、前記エマルションにおいて、閉鎖小胞体はレシチンにより構成され、閉鎖小胞体により包囲されて内包される成分はセタノールであるため、前記エマルション中の構造体の重量は１１質量％である。
<Preparation of emulsion containing structure>
Lecithin (amphiphile) was added to water and stirred to prepare a dispersion of closed vesicles formed of the amphiphile. Cetanol (a hydrated oil) was added to this dispersion, followed by stirring, and emulsification by surrounding cetanol with closed lecithin vesicles to prepare an O / W type emulsion containing the structure. The amount of each component is as shown in Table 1. In the emulsion, the closed endoplasmic reticulum is composed of lecithin, and the component surrounded and enclosed by the closed endoplasmic reticulum is cetanol. Therefore, the weight of the structure in the emulsion is 11% by mass.
＜構造体を含む半永久染毛料の調製＞
前記半永久染毛料に、前記構造体を含むエマルションを、添加後の総量に対し０質量％（比較例１）、１質量％（実施例１）、または５質量％（実施例２）となるようにそれぞれ混合することで、半永久染毛料を調製した。したがって、調製した半永久染毛料における構造体の含有量は、それぞれ０質量％（比較例１）、０．１１質量％（実施例１）、０．５５質量％（実施例２）となる。なお、いずれの半永久染毛料においても、染料の含有量は全体に対し０．０１質量％とした。
<Preparation of semi-permanent hair dye containing structure>
In the semi-permanent hair dye, the emulsion containing the structure is 0% by mass (Comparative Example 1), 1% by mass (Example 1), or 5% by mass (Example 2) based on the total amount after addition. A semi-permanent hair dye was prepared by mixing each. Therefore, the content of the structure in the prepared semi-permanent hair dye is 0% by mass (Comparative Example 1), 0.11% by mass (Example 1), and 0.55% by mass (Example 2), respectively. In any semi-permanent hair dye, the dye content was 0.01% by mass relative to the total.
（染毛性評価）
白髪の毛束（ビューラックス社製）を流水で軽く水洗した後、市販品を使ってシャンプーを行い、キッチンペーパーで毛束の水分をしっかりと拭き取った。その後の毛束に対し、比較例１および実施例１〜２の染毛料０．６ｇを塗り広げ、１分間または５分間に亘って染色を行った。染色後の各毛束を流水で１分間洗浄し、キッチンペーパーで毛束の水分をしっかりと拭き取った後、ドライヤーで乾燥させた。
(Hair dyeing evaluation)
The hair bundle of white hair (Beaulux) was washed lightly with running water, then shampooed using a commercially available product, and the moisture of the hair bundle was wiped off with kitchen paper. After that, 0.6 g of the hair dye of Comparative Example 1 and Examples 1 and 2 was spread on the hair bundle and dyed for 1 minute or 5 minutes. Each hair bundle after dyeing was washed with running water for 1 minute, and after moisture of the hair bundle was wiped off with kitchen paper, it was dried with a dryer.
その後の各毛束の外観を視認し、下の基準で染毛性の評価を行った。この結果を表２に示す。
５点：染まりがとても良い
４点：染まりが良い
３点：どちらとも言えない
２点：染まりが悪い
１点：染まりがとても悪い
The appearance of each subsequent hair bundle was visually confirmed, and the hair dyeing property was evaluated according to the following criteria. The results are shown in Table 2.
5 points: Dyeing is very good 4 points: Dyeing is good 3 points: Neither can be said 2 points: Dyeing is bad 1 point: Dyeing is very bad
表２より、前記構造体を含有する実施例１および２では、前記構造体を含有しない比較例１に比べ、染毛開始１分後で既に染毛が良好に進行し、５分後まで持続した。これにより、染毛料が構造体を含むことで、染毛性を向上できることが分かった。 From Table 2, in Examples 1 and 2 containing the structure, compared to Comparative Example 1 not containing the structure, hair dyeing progressed well 1 minute after the start of hair dyeing and continued until 5 minutes later. did. Thereby, it turned out that hair dyeing property can be improved because a hair dye contains a structure.
（髪への影響評価）
パネラーに頭髪をシャンプーにより洗浄してもらった後、頭髪の半分に比較例１の染毛料を、残り半分に実施例２の染毛料を適用し、５〜１０分後に水洗し、ドライヤーで乾燥させた。翌日の朝に、ヘア用品をつけない状態で頭髪の写真撮影を行った。その写真を用い、下の基準で、「髪のツヤ」、「髪の質感」、「髪のまとまり」を評価した。この結果を表３に示す。
５点：とても良い
４点：良い
３点：どちらとも言えない
２点：悪い
１点：とても悪い
(Evaluation of effects on hair)
After having the panelist wash the hair with shampoo, apply the hair dye of Comparative Example 1 to half of the hair and the hair dye of Example 2 to the other half, wash with water after 5 to 10 minutes, and dry with a dryer. It was. The next morning, I took a photo of my hair with no hair supplies. Using the photographs, the following criteria were used to evaluate “hair gloss”, “hair texture” and “hair mass”. The results are shown in Table 3.
5 points: Very good 4 points: Good 3 points: Cannot say either 2 points: Bad 1 point: Very bad
表３に示されるように、前記構造体を含有する実施例２では、前記構造体を含有しない比較例１に比べ、染毛後の「髪のツヤ」、「髪の質感」、「髪のまとまり」のいずれもが大幅に優れていた。「髪のツヤ」、「髪の質感」、「髪のまとまり」は、キューティクルの開きに悪影響を及ぼされることは知られているので、前記構造体は、染毛後においてキューティクルが開いた状態で固定化されるのを抑制することが示唆された。 As shown in Table 3, in Example 2 containing the structure, compared to Comparative Example 1 not containing the structure, “hair gloss”, “hair texture”, “hair texture” after hair dyeing All of the “mamari” were significantly better. Since it is known that “hair gloss”, “hair texture” and “hair mass” are adversely affected by the opening of the cuticle, the structure is in a state where the cuticle is opened after the hair is dyed. It was suggested to suppress immobilization.
（刺激性評価）
前記構造体を含むエマルションの含有量が０、１または５質量％、塩基性茶１６を０．１質量％、残量が水となるように混合し、染毛料を調製した。なお、この染毛料における構造体の含有量は、それぞれ０、０．１１、０．５５質量％である。
(Irritation evaluation)
A hair dye was prepared by mixing so that the content of the emulsion containing the structure was 0, 1 or 5% by mass, 0.1% by mass of basic tea 16 and the remaining amount being water. In addition, content of the structure in this hair dye is 0, 0.11, and 0.55 mass%, respectively.
ヒト３次元培養皮膚モデルＬａｂＣｙｔｅ ＥＰＩＭＯＤＥＬ２４（Ｊ−ＴＥＣ社製）を用い、その取扱説明書に従って、培養表皮を取り扱った。具体的には、２４ウェルプレートに、ヒト３次元培養表皮用アッセイ培地（Ｊ−ＴＥＣ社製）５００μＬずつ分注し、培養表皮をアルミ包装から取り出し、培養カップをピンセットで取り出した。培養カップをアッセイ培地の入った２４ウェルプレートに移し、３７℃、５％ＣＯ２インキュベーター内で２４時間前培養した。各ウェルより培地を除去した後、各染毛料を培養カップ内に５０μＬ添加し、ＣＯ２インキュベーター内で１８時間培養した。また、ポジティブコントロールとして、０．１％ポリオキシエチレンラウリルエーテルを５０μＬ添加した。培養後、ＰＢＳ５００μｇ／ｍＬでカップ内を５回洗浄し、更にＣＯ２インキュベーター内で２４時間培養した。ＭＴＴ（3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide）をＤＭＥＭ（Dulbeccoo’s Modified Eagle’s Medium）に５００μｇ／ｍＬとなるように溶解し、フィルター処理することでＭＴＴ含有培地を調製した。２４ウェルプレートにMTT含有培地を５００μＬずつ添加し、３７℃、ＣＯ２インキュベーター内で１時間加温した。ＭＴＴ含有培地を添加したプレートに培養カップを移し、３７℃、ＣＯ２インキュベーター内で３時間インキュベートした。培養カップ外の培地は回収し、ＩＬ−１α Ｈｕｍａｎ、ＥＩＡ ｋｉｔ（Ｃａｙｍａｎ Ｃｈｅｍｉｃａｌ Ｃｏｍｐａｎｙ製）に供した。このキットの取扱説明書に従い、各試料のＩＬ−１α量を測定した結果を、図２に示す。 Using a human three-dimensional cultured skin model LabCyte EPIMODEL24 (manufactured by J-TEC), the cultured epidermis was handled according to the instruction manual. Specifically, 500 μL of human three-dimensional culture epidermis assay medium (manufactured by J-TEC) was dispensed into a 24-well plate, the culture epidermis was taken out of the aluminum package, and the culture cup was taken out with tweezers. The culture cup was transferred to a 24-well plate containing assay medium and pre-cultured for 24 hours in a 37 ° C., 5% CO 2 incubator. After removing the medium from each well, 50 μL of each hair dye was added to the culture cup and cultured in a CO 2 incubator for 18 hours. As a positive control, 50 μL of 0.1% polyoxyethylene lauryl ether was added. After culturing, the inside of the cup was washed 5 times with PBS 500 μg / mL, and further cultured in a CO 2 incubator for 24 hours. Dissolve MTT (3- (4,5-dimethyl-2-thiazolyl) -2,5-diphenyl-2H-tetrazolium bromide) in DMEM (Dulbeccoo's Modified Eagle's Medium) to 500 μg / mL and filter it. A medium containing MTT was prepared. 500 μL of MTT-containing medium was added to each 24-well plate and heated in a CO 2 incubator at 37 ° C. for 1 hour. The culture cup was transferred to a plate supplemented with MTT-containing medium and incubated at 37 ° C. in a CO 2 incubator for 3 hours. The medium outside the culture cup was collected and used for IL-1α Human and EIA kit (manufactured by Cayman Chemical Company). The results of measuring the amount of IL-1α of each sample according to the instruction manual of this kit are shown in FIG.
図２に示されるように、構造体の含有量に依存的に、炎症性物質ＩＬ−１αの量が減少した。これにより、染毛料における構造体が、毛髪への刺激を抑制できることが分かった。 As shown in FIG. 2, the amount of the inflammatory substance IL-1α decreased depending on the content of the structure. Thereby, it turned out that the structure in a hair dye can suppress the irritation | stimulation to hair.
＜染毛剤（第１剤）の調製＞
水、セトスレアリルアルコール、ベヘニルアルコール、パルミチン酸セチル、パルミチン酸２−エチルヘキシル、並びに、染料としてレゾルシン、パラアミノフェノール、メタアミノフェノール、塩酸２，４−ジアミノフェノキシエタノール、パラフェニレンジアミン、および５−アミノオルトクレゾールを適量ずつ撹拌し、Ｏ／Ｗ型エマルションの染毛剤（染毛剤組成物）の第１剤を調製した。
<Preparation of hair dye (first agent)>
Water, cetoreal alcohol, behenyl alcohol, cetyl palmitate, 2-ethylhexyl palmitate, and resorcin, paraaminophenol, metaaminophenol, 2,4-diaminophenoxyethanol hydrochloride, paraphenylenediamine, and 5-aminoorthocresol as dyes Were mixed in appropriate amounts to prepare a first agent of a hair dye (hair dye composition) of an O / W emulsion.
＜染毛剤（第２剤）の調製＞
水に、過酸化水素水、セトステアリルアルコール、ミリスチルアルコール、ポリオキシエチレンセチルエーテル、およびポリオキシエチレンオレイルエーテルを適量ずつ混合することで、染毛剤の第２剤を調製した。
<Preparation of hair dye (second agent)>
A second agent of the hair dye was prepared by mixing an appropriate amount of hydrogen peroxide, cetostearyl alcohol, myristyl alcohol, polyoxyethylene cetyl ether, and polyoxyethylene oleyl ether with water.
＜構造体を含むエマルションの調製＞
水にレシチン（両親媒性物質）を加えて撹拌し、両親媒性物質により形成された閉鎖小胞体の分散液を調製した。この分散液にセタノール（抱水性油剤）を加えて撹拌し、レシチンの閉鎖小胞体によってセタノールを包囲させて乳化することにより、構造体を含むＯ／Ｗ型エマルションを調製した。各成分の配合量は、表４に示すとおりである。なお、前記エマルションにおいて、閉鎖小胞体はレシチンにより構成され、閉鎖小胞体により包囲されて内包される成分はセタノールであるため、前記エマルション中の構造体の重量は１１質量％である。
<Preparation of emulsion containing structure>
Lecithin (amphiphile) was added to water and stirred to prepare a dispersion of closed vesicles formed of the amphiphile. Cetanol (a hydrated oil) was added to this dispersion, followed by stirring, and emulsification by surrounding cetanol with closed lecithin vesicles to prepare an O / W type emulsion containing the structure. The amount of each component is as shown in Table 4. In the emulsion, the closed endoplasmic reticulum is composed of lecithin, and the component surrounded and enclosed by the closed endoplasmic reticulum is cetanol. Therefore, the weight of the structure in the emulsion is 11% by mass.
＜構造体を含む染毛剤（第１剤）の調製＞
前記染毛剤（第１剤）に、前記構造体を含むエマルションを、添加後の第１剤総量に対し０質量％（比較例２）、１質量％（実施例３）または５質量％（実施例４）ずつ混合することで、染毛剤の第１剤を調製した。したがって、調製した染毛剤（第１剤）における構造体の含有量は、それぞれ０質量％（比較例２）、０．１１質量％（実施例３）または０．５５質量％（実施例４）となる。
<Preparation of hair dye containing structure (first agent)>
In the hair dye (first agent), the emulsion containing the structure is 0% by mass (Comparative Example 2), 1% by mass (Example 3) or 5% by mass (total) with respect to the total amount of the first agent after addition. Example 4) The first agent of the hair dye was prepared by mixing each one. Therefore, the content of the structure in the prepared hair dye (first agent) is 0% by mass (Comparative Example 2), 0.11% by mass (Example 3) or 0.55% by mass (Example 4), respectively. )
（染毛性評価１）
使用直前に、第２剤と、比較例２および実施例３の第１剤とを１：１の質量比で混合した。混合後における構造体の含有量は、それぞれ０質量％（比較例２）、０．０５５質量％（実施例３）または０．２７５質量％（実施例４）となる。混合後、染毛剤１ｇを白髪の毛束（ビューラックス社製）に塗り広げ、５分間または１５分間に亘って染色を行った。染色後の各毛束を流水で１分間洗浄し、ドライヤーで乾燥させた。
(Hair dyeing evaluation 1)
Immediately before use, the second agent and the first agent of Comparative Example 2 and Example 3 were mixed at a mass ratio of 1: 1. The content of the structure after mixing is 0% by mass (Comparative Example 2), 0.055% by mass (Example 3), or 0.275% by mass (Example 4), respectively. After mixing, 1 g of the hair dye was spread on a white hair bundle (manufactured by Beaulux) and dyed for 5 minutes or 15 minutes. Each hair bundle after dyeing was washed with running water for 1 minute and dried with a dryer.
その後の各毛束の外観を視認し、下の基準で染毛性の評価を行った。この結果を表５に示す。
５点：染まりがとても良い
４点：染まりが良い
３点：どちらとも言えない
２点：染まりが悪い
１点：染まりがとても悪い
The appearance of each subsequent hair bundle was visually confirmed, and the hair dyeing property was evaluated according to the following criteria. The results are shown in Table 5.
5 points: Dyeing is very good 4 points: Dyeing is good 3 points: Neither can be said 2 points: Dyeing is bad 1 point: Dyeing is very bad
表５より、前記構造体を含有する実施例３では、前記構造体を含有しない比較例２に比べ、染毛開始５分後で既に染毛が良好に進行し、１５分後まで持続した。これにより、染毛剤が構造体を含むことで、染毛性を向上できることが分かった。 From Table 5, in Example 3 containing the said structure, compared with the comparative example 2 which does not contain the said structure, the hair dyeing progressed well already after 5 minutes of hair dyeing, and continued until 15 minutes later. Thereby, it turned out that hair dyeing property can be improved because a hair dye contains a structure.
（染毛性評価２）
１０％過酸化水素水と１０％アンモニア水を１:１で混合し、白髪の毛束（ビューラックス社製）を浸け、室温で３０分間静置した後、流水で５分間洗浄し、キッチンペーパーで水気を拭き取った後、ドライヤーで乾燥させた。この工程を３回繰り返した後の毛束を１０％（ｗ／ｗ）ＳＤＳ水溶液に浸し、７０℃で７２時間静置した後、流水で十分に洗浄することで、ダメージ毛を作成した。
(Hair dyeing evaluation 2)
Mix 10% hydrogen peroxide solution and 10% ammonia solution 1: 1, soak the white hair bundle (made by Beaulux), let it stand at room temperature for 30 minutes, then wash with running water for 5 minutes, and use kitchen paper. After wiping off moisture, it was dried with a dryer. The hair bundle after repeating this process three times was immersed in a 10% (w / w) SDS aqueous solution, allowed to stand at 70 ° C. for 72 hours, and then washed thoroughly with running water to create damaged hair.
比較例２および実施例３〜４の染毛剤第１剤に、１％（ｗ／ｗ）のフルオレセインナトリウムを混合し、第２剤を１：１の質量比で混合した。この混合物に、前記ダメージ毛を速やかに浸漬し、１、５、１０、または３０分間処理した後、３０秒間流水で洗浄した。水気を拭き取った後、凍結ブロックを作製し、その凍結切片を蛍光顕微鏡で観察した。この結果を図３に示す。 1% (w / w) sodium fluorescein was mixed with the first hair dye of Comparative Example 2 and Examples 3 to 4, and the second agent was mixed at a mass ratio of 1: 1. The damaged hair was immediately immersed in this mixture, treated for 1, 5, 10, or 30 minutes, and then washed with running water for 30 seconds. After wiping off the water, a frozen block was prepared, and the frozen section was observed with a fluorescence microscope. The result is shown in FIG.
図３に示されるように、前記構造体を含有する実施例３および４では、前記構造体を含有しない比較例２に比べ、染毛開始１分後で既に染毛が良好に進行し、３０分後まで持続した。具体的に、実施例３および４では、染毛開始１分後で、キューティクルに染料が侵入し、５分後以降にはコルテックス（毛皮質）へと多量の染料が侵入し、内部まで高度に染毛できていた。これに対し、比較例２では、染毛３０分後においても、相対的に低程度の染料がキューティクルに侵入するにとどまり、コルテックスへの侵入は極めて限定的であった。このように、染毛剤が構造体を含むことで、染毛性を向上できることが分かった。 As shown in FIG. 3, in Examples 3 and 4 containing the structure, the hair dyeing progressed well after 1 minute from the start of hair dyeing, compared to Comparative Example 2 containing no structure. Persisted until after a minute. Specifically, in Examples 3 and 4, the dye entered the cuticle 1 minute after the start of hair dyeing, and after 5 minutes, a large amount of dye entered the cortex (fur) and advanced to the inside. I was able to dye my hair. On the other hand, in Comparative Example 2, even after 30 minutes of hair dyeing, only a relatively low amount of dye entered the cuticle, and the penetration into the cortex was very limited. Thus, it turned out that hair dyeing property can be improved because a hair dye contains a structure.
（髪への影響評価）
使用直前に、第２剤と、比較例２および実施例３の第１剤とを１：１の質量比で混合し、混合後の染毛剤１ｇを白髪の毛束（ビューラックス社製）に塗り広げ、３０分間に亘って染色を行った。染色後の各毛束を流水で１分間洗浄し、ドライヤーで乾燥させた。この毛束に対し、摩擦感テスター（カトーテック社製）で毛束の平均摩擦係数を測定した。この結果を表６に示す。
(Evaluation of effects on hair)
Immediately before use, the second agent and the first agent of Comparative Example 2 and Example 3 were mixed at a mass ratio of 1: 1, and 1 g of the hair dye after mixing was mixed into a gray hair bundle (manufactured by Beaulux). Spreaded and dyed for 30 minutes. Each hair bundle after dyeing was washed with running water for 1 minute and dried with a dryer. For this hair bundle, the average friction coefficient of the hair bundle was measured with a friction tester (manufactured by Kato Tech Co., Ltd.). The results are shown in Table 6.
表６に示されるように、前記構造体を含有する実施例３では、前記構造体を含有しない比較例２に比べ、平均摩擦係数が有意に低く、髪表面が滑らかに整えられていることが分かった。 As shown in Table 6, in Example 3 containing the structure, the average friction coefficient was significantly lower than that of Comparative Example 2 not containing the structure, and the hair surface was smooth. I understood.
（刺激性評価）
前記構造体を０、１または５質量％、パラアミノフェノールおよびメタアミノフェノールを０．０１質量％ずつ、並びに残量の精製水を混合し、染毛剤を調製した。なお、この染毛剤における構造体の含有量は、それぞれ０、０．０５５、０．２７５質量％である。その他は、実施例１における刺激性評価試験と同じ手順で、刺激性評価を行った。この結果を図４に示す。
(Irritation evaluation)
A hair dye was prepared by mixing 0, 1 or 5% by mass of the structure, 0.01% by mass of paraaminophenol and metaaminophenol, and the remaining amount of purified water. In addition, content of the structure in this hair dye is 0, 0.055, and 0.275 mass%, respectively. Other than that, the irritation evaluation was performed in the same procedure as the irritation evaluation test in Example 1. The result is shown in FIG.
図４に示されるように、前記構造体を含む染毛剤は、構造体を含まない染毛剤に比べて、炎症性物質ＩＬ−１αの量が低かった。これにより、染毛剤における構造体が、毛髪への刺激を抑制できることが分かった。なお、構造体の含有量が０．０５５質量％の場合と０．２７５質量％の場合を比較しても、ＩＬ−１αの量に有意な差は認められなかった。これは、構造体の含有量が０．０５５質量％の段階で、毛髪の量に対して既に構造体が飽和して付着しているため、構造体の含有量を０．０５５質量％以上にしても差が出なかったものと推察される。 As shown in FIG. 4, the amount of the inflammatory substance IL-1α was lower in the hair dye containing the structure than in the hair dye not containing the structure. Thereby, it turned out that the structure in a hair dye can suppress the irritation | stimulation to hair. Even when the structure content was 0.055 mass% and 0.275 mass%, no significant difference was found in the amount of IL-1α. This is because when the structure content is 0.055% by mass, the structure is already saturated and attached to the amount of hair, so the content of the structure is 0.055% by mass or more. It is speculated that there was no difference.
Claims (6)
自発的に閉鎖小胞体を形成する両親媒性物質により形成された閉鎖小胞体が、外相をなす水相と、内相をなす油相との界面に介在して前記油相を包囲し、
前記閉鎖小胞体は、平均粒子径８ｎｍ〜５００ｎｍである染毛剤組成物。 Contains oils, aqueous ingredients and dyes,
A closed vesicle formed by an amphiphile that spontaneously forms a closed vesicle surrounds the oil phase by interposing an interface between an aqueous phase that forms an outer phase and an oil phase that forms an inner phase,
The closed vesicle is a hair dye composition having an average particle diameter of 8 nm to 500 nm .
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015002995A JP5817085B1 (en) | 2015-01-09 | 2015-01-09 | Hair dye composition |
| JP2015170970A JP6600907B2 (en) | 2015-01-09 | 2015-08-31 | Hair dye composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015002995A JP5817085B1 (en) | 2015-01-09 | 2015-01-09 | Hair dye composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP5817085B1 true JP5817085B1 (en) | 2015-11-18 |
Family
ID=54602137
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015002995A Active JP5817085B1 (en) | 2015-01-09 | 2015-01-09 | Hair dye composition |
| JP2015170970A Active JP6600907B2 (en) | 2015-01-09 | 2015-08-31 | Hair dye composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015170970A Active JP6600907B2 (en) | 2015-01-09 | 2015-08-31 | Hair dye composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JP5817085B1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018180514A1 (en) * | 2017-03-29 | 2018-10-04 | 株式会社マンダム | Hair dye composition |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09309817A (en) * | 1996-05-20 | 1997-12-02 | Shiseido Co Ltd | Acidic hair dye and its production |
| JP2006111627A (en) * | 2004-10-15 | 2006-04-27 | Clariant Produkte (Deutschland) Gmbh | Cosmetic, drug and skin care preparation |
| JP2006239666A (en) * | 2004-04-05 | 2006-09-14 | Univ Kanagawa | Emulsifying dispersant, method for emulsification and dispersion using it, and emulsion |
| JP2012144580A (en) * | 2012-05-08 | 2012-08-02 | Asahi Kasei Chemicals Corp | Oil film-forming emulsified composition |
| JP2013010935A (en) * | 2011-05-30 | 2013-01-17 | Dow Corning Toray Co Ltd | Organopolysiloxane elastomer modified with mono-/diglycerin derivative, and use therefor |
| JP2013095834A (en) * | 2011-10-31 | 2013-05-20 | Dow Corning Toray Co Ltd | Long chain hydrocarbon-modified silicone/amino-modified silicone copolymer and use of the same |
| JP2014088372A (en) * | 2012-10-02 | 2014-05-15 | Kose Corp | Keratin fiber coloring agent |
| JP2015007013A (en) * | 2013-06-25 | 2015-01-15 | 学校法人神奈川大学 | Cosmetics for hair care or nail care |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3462350B2 (en) * | 1996-08-26 | 2003-11-05 | 株式会社資生堂 | Emulsion for hair treatment |
| JPH09249537A (en) * | 1996-03-13 | 1997-09-22 | Shiseido Co Ltd | Oxidation hair dye and its production |
| FR2760641B1 (en) * | 1997-03-13 | 2000-08-18 | Oreal | STABLE OIL-IN-WATER EMULSION, MANUFACTURING METHOD THEREOF AND USE THEREOF IN THE COSMETIC AND DERMATOLOGICAL FIELDS |
| JP2013006822A (en) * | 2011-05-24 | 2013-01-10 | Kanagawa Univ | Emulsified product, and method for producing the same |
| JP2014141478A (en) * | 2012-12-27 | 2014-08-07 | Univ Kanagawa | Irritation mitigating agent of external preparation for skin or cosmetic preparation, and method for mitigating irritation |
| JP2014234347A (en) * | 2013-05-31 | 2014-12-15 | 三洋化成工業株式会社 | Shampoo compositions for dyed hair |
-
2015
- 2015-01-09 JP JP2015002995A patent/JP5817085B1/en active Active
- 2015-08-31 JP JP2015170970A patent/JP6600907B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09309817A (en) * | 1996-05-20 | 1997-12-02 | Shiseido Co Ltd | Acidic hair dye and its production |
| JP2006239666A (en) * | 2004-04-05 | 2006-09-14 | Univ Kanagawa | Emulsifying dispersant, method for emulsification and dispersion using it, and emulsion |
| JP2006111627A (en) * | 2004-10-15 | 2006-04-27 | Clariant Produkte (Deutschland) Gmbh | Cosmetic, drug and skin care preparation |
| JP2013010935A (en) * | 2011-05-30 | 2013-01-17 | Dow Corning Toray Co Ltd | Organopolysiloxane elastomer modified with mono-/diglycerin derivative, and use therefor |
| JP2013095834A (en) * | 2011-10-31 | 2013-05-20 | Dow Corning Toray Co Ltd | Long chain hydrocarbon-modified silicone/amino-modified silicone copolymer and use of the same |
| JP2012144580A (en) * | 2012-05-08 | 2012-08-02 | Asahi Kasei Chemicals Corp | Oil film-forming emulsified composition |
| JP2014088372A (en) * | 2012-10-02 | 2014-05-15 | Kose Corp | Keratin fiber coloring agent |
| JP2015007013A (en) * | 2013-06-25 | 2015-01-15 | 学校法人神奈川大学 | Cosmetics for hair care or nail care |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6600907B2 (en) | 2019-11-06 |
| JP2016130233A (en) | 2016-07-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8716214B2 (en) | Compositions for the targetted release of fragrances and aromas | |
| CA2038331C (en) | Composition for the comestic and/or pharmaceutic treatment of the superior layers of the skin by topical application on the skin and corresponding preparation process | |
| KR101318089B1 (en) | Continuous moisturization compositions | |
| JP6016728B2 (en) | Ceramide dispersion composition | |
| ES2832923T3 (en) | Cosmetic hair conditioner compositions containing a mixture of amidoamines | |
| JP4308472B2 (en) | Highly unsaponifiable matter and method of using the same | |
| JP6089152B2 (en) | Exfoliating hair retention promoting formulation | |
| CN101543465A (en) | Cosmetic composition comprising imidopercarboxylic acid derivative and n-acylated amino acid ester | |
| JP5911664B2 (en) | Cosmetic or dermatological composition containing a specific surfactant and glucose and vitamin F derivatives | |
| RU2376009C2 (en) | New composition for skin care | |
| JP6600907B2 (en) | Hair dye composition | |
| JP6883723B2 (en) | Liposomes, liposome solutions and cosmetics, and methods for producing the above liposomes. | |
| JP6685524B1 (en) | Beauty treatment method, shampoo and wetting agent used therefor | |
| CN101146509B (en) | Enhanced delivery of skin benefit agents | |
| TWI719035B (en) | Hair dye composition | |
| JP6869500B2 (en) | External preparations and methods for manufacturing external preparations | |
| JP6340677B2 (en) | Bath additive | |
| JP4257098B2 (en) | Hair dye, method for producing the same and hair dyeing method using the same | |
| JP2673887B2 (en) | Cosmetics | |
| JP6599851B2 (en) | In bath treatment composition | |
| JP4246150B2 (en) | Skin cosmetic composition | |
| JP7144019B1 (en) | oral composition | |
| JP5719229B2 (en) | Vesicle composition and use thereof | |
| FR2956813A1 (en) | Shampoo, useful for washing and/or hair care and scalp, comprises detersive surfactant component comprising an anionic detergent surfactant, emollient derived from vegetable oil, an active agent and water | |
| RU2241440C2 (en) | Cosmetic preparation for taking care of problematic skin and method for its obtaining |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150313 |
|
| A871 | Explanation of circumstances concerning accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A871 Effective date: 20150318 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150318 |
|
| A975 | Report on accelerated examination |
Free format text: JAPANESE INTERMEDIATE CODE: A971005 Effective date: 20150428 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150512 |
|
| RD13 | Notification of appointment of power of sub attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7433 Effective date: 20150611 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150707 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150811 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20150811 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20150812 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20150908 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20150911 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5817085 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |