JP5537141B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that analyzes components contained in a liquid, and more particularly to an automatic analyzer that analyzes components contained in body fluids such as human blood and urine.

  The automatic analyzer is intended for biochemical test items, immunological test items, etc., and changes in color and turbidity caused by the reaction of the mixture of the test sample collected from the sample and the reagent of each test item are measured with a spectrophotometer. Optical data is measured by a photometric unit such as a turbidimeter or an nephelometer, thereby generating analysis data represented by concentrations of various test item components in the test sample, enzyme activities, and the like.

  In this automatic analyzer, an inspection target item selected from a large number of inspection items is analyzed for each test sample. In order to perform the analysis, the test sample is dispensed from the sample container to the reaction container with the sample dispensing probe, and the reagent for each test item is dispensed from the reagent container to the reaction container with the reagent dispensing probe. Next, the test sample and reagent mixture dispensed in the reaction vessel are stirred with a stirrer and then measured with a photometric unit. Further, after washing the sample and reagent dispensing probe in contact with the test sample and reagent, the stirrer and the reaction container in contact with the mixed solution, the sample is repeatedly used for measurement.

  By the way, the photometric unit uses a number of wavelengths to measure the mixed solution according to the reaction of the mixed solution of various inspection items, so that the diffraction grating that separates the light from the light source and each wavelength that has been dispersed A light detector for detecting the light intensity of the light is used. Further, a light source such as a halogen lamp capable of obtaining a high light intensity from the near ultraviolet region to the near infrared region is used so that the mixed liquid of various inspection items can be measured (see, for example, Patent Document 1). ).

  When a light source having a filament, such as a halogen lamp, is lit for a long time, the light intensity decreases with the deterioration of the filament, so that the light source is replaced every predetermined period. In addition, the light metering unit can monitor the light emitted from the light source and detect an abnormality of the light source in which the light intensity falls outside the allowable range within a predetermined period.

JP 2008-58151 A

  However, even if the light intensity is within an allowable range within a predetermined period, the filament is deformed and deviates from the optical axis of the photometry unit, and the wavelength of light detected by the photodetector deviates. There is a problem that analytical data such as an enzyme activity value generated using a factor including a molecular extinction coefficient in the sample deteriorates.

  The present invention has been made to solve the above problems, and an object of the present invention is to provide an automatic analyzer that can prevent a decrease in wavelength accuracy due to deformation of a filament.

In order to achieve the above object, the automatic analyzer of the present invention irradiates light to a reaction vessel containing a mixture of a test sample and a reagent and separates the light transmitted through the mixture with a diffraction grating. in an automatic analyzer for measuring the mixture by detecting the spectrum, and have a filament as a light source for irradiating the reaction vessel, the filament is arranged so as to be positioned on the optical axis the light source , Based on position information detected by the position detecting means by detecting position of the filament by detecting zero order light emitted from the diffraction grating by irradiation of light from the light source , And correction means for correcting a positional deviation of the light from the light source with respect to the optical axis .

  According to the present invention, it is possible to prevent the wavelength accuracy from deteriorating by preventing the positional deviation of the light from the optical axis due to the deformation of the filament, and the analysis data can be prevented from deteriorating.

1 is a block diagram showing a configuration of an automatic analyzer according to Embodiment 1 of the present invention. The perspective view which shows the structure of the analysis part which concerns on Example 1 of this invention. FIG. 3 is a top view illustrating a configuration of a photometry unit according to the first embodiment of the invention. The figure which shows the structure of the light source and shielding board which concern on Example 1 of this invention. The figure for demonstrating the shielding board which concerns on Example 1 of this invention. The figure for demonstrating the shielding board which concerns on Example 1 of this invention. FIG. 6 is a top view showing a configuration of a photometry unit according to Embodiment 2 of the present invention. 9 is a flowchart showing the operation of a photometry unit according to Embodiment 2 of the present invention. The figure which shows an example for demonstrating correction | amendment of the light from the filament which concerns on Example 2 of this invention. FIG. 6 is a top view illustrating a configuration of a photometry unit according to Embodiment 3 of the present invention. 10 is a flowchart showing the operation of a photometry unit according to Embodiment 3 of the present invention.

  Examples of the present invention will be described below.

  A first embodiment of an automatic analyzer according to the present invention will be described below with reference to FIGS.

  FIG. 1 is a block diagram showing the configuration of the automatic analyzer according to the first embodiment of the present invention. This automatic analyzer 100 measures a standard sample of each test item or a test sample collected from a sample and a reagent corresponding to each test item and generates standard data and test data. 24, and an analysis control unit 25 that drives and controls each analysis unit related to the measurement of the analysis unit 24.

  Also, the standard data and test data generated by the analysis unit 24 are processed to generate calibration data and analysis data, and the calibration data and analysis data generated by the data processing unit 30 are printed out. And an output unit 40 for displaying and outputting, an operation unit 50 for inputting various command signals, and the like, an analysis control unit 25, a data processing unit 30, and a system control unit 60 for controlling the output unit 40 in an integrated manner. Yes.

  FIG. 2 is a perspective view showing the configuration of the analysis unit 24. The analysis unit 24 includes a sample container 17 that accommodates each sample such as a standard sample and a test sample, a sample disk 5 that holds the sample container 17, and one reagent that reacts with a component of an inspection item included in each sample. A reagent container 6 for storing a first reagent of a system and a two reagent system, a reagent container 1 having a reagent rack 1a for rotatably holding the reagent container 6, and a first reagent that forms a pair with a first reagent of a two reagent system A reagent container 7 containing two reagents, a reagent container 2 having a reagent rack 2a for rotatably holding the reagent container 7, and a reaction for rotatably holding a plurality of reaction containers 3 arranged on the circumference And a disk 4.

  In addition, a sample dispensing probe 16 for dispensing each sample in the sample container 17 held on the sample disk 5 and sucking it into the reaction container 3, and rotating and moving the sample dispensing probe 16 up and down. A sample dispensing arm 10 that can be held and a washing tank 16a that cleans the sample dispensing probe 16 each time dispensing of each sample is provided.

  Also, a first reagent dispensing probe 14 for aspirating the first reagent in the reagent container 6 housed in the reagent store 1 and dispensing it into the reaction container 3 from which each sample has been discharged, and the first reagent A first reagent dispensing arm 8 that holds the dispensing probe 14 so that the dispensing probe 14 can be rotated and moved up and down, and a washing tank 14a that cleans the first reagent dispensing probe 14 every time the dispensing of the first reagent is completed. .

  Also, a first stirrer 18 that stirs the mixed solution of each sample and the first reagent discharged into the reaction vessel 3, and a first stirrer arm 20 that holds the first stirrer 18 so as to be rotatable and vertically movable. And a washing tank 18a for washing the first stirring bar 18 every time the stirring of the mixed solution is completed.

  Also, a second reagent dispensing probe 15 for aspirating the second reagent in the reagent container 7 stored in the reagent storage 2 and dispensing it into the reaction container 3 from which each sample and first reagent are discharged; A second reagent dispensing arm 9 for holding the second reagent dispensing probe 15 so as to be rotatable and vertically movable, and a washing tank 15a for washing the second reagent dispensing probe 15 every time the second reagent dispensing is completed. It has.

  Also, a second stirrer 19 that stirs the mixed solution of each sample, first reagent, and second reagent in the reaction vessel 3, and a second stirrer arm that holds the second stirrer 19 so as to be rotatable and vertically movable. 21 and a washing tank 19a for washing the second stirrer 19 every time the mixed solution is stirred.

  Moreover, the photometric part 13 which irradiates light to the liquid mixture in the reaction container 3 and measures optically, and the reaction container washing | cleaning part 12 which wash | cleans the inside of the reaction container 3 which completed the measurement in the photometric part 13 are provided. .

  Then, the photometry unit 13 irradiates the reaction container 3 with light, and based on the detection signal for detecting the wavelength light of each inspection item that has passed through the liquid mixture containing the standard sample and the test sample in the reaction container 3, For example, standard data or test data expressed by absorbance or the amount of change in absorbance is generated. Then, the generated standard data and test data are output to the data processing unit 30.

  The analysis control unit 25 includes a mechanism unit 26 having a mechanism for driving each analysis unit of the analysis unit 24 and a control unit 27 for controlling each mechanism of the mechanism unit 26. Then, the mechanism unit 26 stops after rotating the sample disk 5, the reagent rack 1a of the reagent storage 1 and the reagent rack 2a of the reagent storage 2, and the reaction disk 4 for each analysis cycle. It has a mechanism to do. The sample dispensing arm 10, the first reagent dispensing arm 8, the second reagent dispensing arm 9, the first stirring arm 20, and the second stirring arm 21 are each provided with a mechanism for rotating and moving up and down. .

  The data processing unit 30 shown in FIG. 1 includes a calculation unit 31 that processes standard data and test data output from the photometry unit 13 of the analysis unit 24 to generate calibration data and analysis data for each inspection item, A data storage unit 32 for storing the standard data and analysis data generated by the unit 31.

  The calculation unit 31 generates calibration data representing the relationship between the concentration and activity of each test item component and the standard data from the standard data output from the photometry unit 13 and the standard values preset in the standard sample of the standard data. The generated calibration data is output to the output unit 40 and stored in the data storage unit 32.

  In addition, the calibration data of the inspection item corresponding to the test data represented by the absorbance output from the photometry unit 13 is read from the data storage unit 32, and the test data output from the photometry unit 13 using the read calibration data. Analytical data expressed as concentration values is generated from Further, analysis data represented as an activity value of the enzyme is generated by multiplying the test data represented by the amount of change in absorbance by a factor including a molecular extinction coefficient at a predetermined wavelength set as an analysis parameter. The generated analysis data is output to the output unit 40 and stored in the data storage unit 32.

  The data storage unit 32 includes a memory device such as a hard disk, and stores the calibration data output from the calculation unit 31 for each inspection item. Moreover, the analysis data of each inspection item output from the calculation unit 31 is stored for each test sample.

  The output unit 40 includes a printing unit 41 that prints out calibration data and analysis data output from the calculation unit 31 of the data processing unit 30 and a display unit 42 that displays and outputs the calibration data. The printing unit 41 includes a printer or the like, and prints the calibration data and analysis data output from the calculation unit 31 on printer paper or the like according to a preset format.

  The display unit 42 includes a monitor such as a CRT or a liquid crystal panel, and displays calibration data and analysis data output from the calculation unit 31. In addition, an analysis parameter setting screen for setting analysis parameters of each inspection item that can be inspected by the automatic analyzer 100, a reagent information setting screen for setting reagent information of a reagent corresponding to each inspection item, and each test sample A test sample information setting screen for setting identification information such as a name and ID for identifying the test sample and an inspection item to be inspected is displayed.

  The operation unit 50 includes input devices such as a keyboard, a mouse, a button, and a touch key panel, and performs an operation for setting analysis parameters, reagent information, identification information of test samples, test items, and the like for each test item. In addition, an operation for analyzing the inspection item is performed for each test sample set on the test sample information setting screen of the display unit 42.

  The system control unit 60 includes a CPU and a storage circuit, and includes a command signal input by an operation from the operation unit 50, analysis parameter information for each test item, reagent information, test sample identification information, test item information, and the like. Are stored in the storage circuit, and based on these input information, the analysis control unit 25, the data processing unit 30, and the output unit 40 are integrated to control the entire system.

  Hereinafter, an example of the configuration of the photometry unit 13 in the analysis unit 24 will be described with reference to FIGS. 1 to 6. FIG. 3 is a top view showing the configuration of the photometry unit 13. FIG. 4 is a diagram showing a part of the units constituting the photometry unit 13. 5 and 6 are diagrams for explaining the unit shown in FIG.

  In FIG. 3, the photometry unit 13 includes a light source 71 disposed on an optical axis 70 such as a halogen lamp that emits white light, a shielding plate 72 having an opening 721 that restricts light from the light source 71, and a shielding plate. For example, a first condenser lens 73 that condenses the light that has passed through 72 in the reaction container 3, and a second condenser lens 74 that condenses the light that has passed through the liquid mixture in the reaction container 3 in the slit 75. Consists of.

  Further, a diffraction grating 76 that splits the light that has passed through the slit 75, a photodetector 77 that has a photodiode that detects the spectrum dispersed by the diffraction grating 76 for each wavelength and converts it into an electrical signal, and a photodetector 77. And a signal processing unit 78 for processing standard signals and test data.

  FIG. 4 is a diagram showing the configuration of the light source 71 and the shielding plate 72. 4A is a front view of the light source 71 and the shielding plate 72 viewed from the direction of the optical axis 70 on the first condenser lens 73 side, and FIG. 4B is a diagram of the light source 71 and the shielding plate 72. It is a side view.

  The light source 71 has a filament 712 made of tungsten spirally wound around a central axis 711 that emits light for irradiating the reaction vessel 3. And it replaces | exchanges after using for a predetermined period, and it attaches so that the center axis | shaft 711 may orthogonally cross the optical axis 70 at the time of replacement | exchange.

  The shielding plate 72 is disposed between the light source 71 and the first condenser lens 73 so as to be separated from the optical axis 70 and has an opening 721 through which light from the light source 71 passes. Then, the opening 721 projects onto the shielding plate 72 as shown in FIG. 5B by applying virtual parallel light to the filament 712 with respect to the optical axis 70 as shown in FIG. 5A. Provided in the region of the image indicated by the broken line.

  As shown in FIG. 6, when the image projected on the shielding plate 72 is not included in the opening 721, for example, when the length in the width direction is a filament 713 relatively shorter than the opening 721, the filament 713 is By deformation, the light emission center is parallel to the spectrum plane dispersed by the diffraction grating 76 from the optical axis 70 and is in the direction of the arrow L1 which is the direction perpendicular to the optical axis 70 or the direction opposite to the L1 direction. When shifted in the direction of the arrow L2, the center of the light passing through the opening 721 is shifted from the optical axis 70 in the L1 direction or the L2 direction. Thereby, the position incident on the diffraction grating 76 is shifted in the L1 direction or the L2 direction, and the position incident on the detector 77 of the light of each wavelength dispersed by the diffraction grating 76 is shifted. Due to this positional shift, the wavelength of light detected by the photodetector 77 is shifted.

  Therefore, by arranging the shielding plate 72 between the light source 71 and the first condenser lens 73 and setting the opening 721 of the shielding plate 72 to a size included in the region of the filament 712 image, the filament 712 has a predetermined shape. Even when it is deformed by use of the period of time and deviates in the L1 direction or the L2 direction, the center of light passing through the opening 721 is deviated from the optical axis 70 because the emission center is relatively wide with respect to the opening 721. Can be prevented. This makes it possible to prevent a shift in the wavelength of the light detected by the photodetector 77 and prevent deterioration of analytical data such as an enzyme activity value generated using a factor including a molecular extinction coefficient at a predetermined wavelength. be able to.

  According to the first embodiment of the present invention described above, the shielding plate 72 is disposed between the light source 71 and the reaction vessel 3 and projected onto the shielding plate 72 by applying virtual parallel light to the optical axis 70. By providing the opening 721 in the region of the image of the filament 712, it is possible to prevent a decrease in wavelength accuracy due to the deformation of the filament 712, and it is possible to prevent deterioration of analysis data.

  The second embodiment of the photometric unit of the automatic analyzer according to the present invention will be described below with reference to FIGS.

  FIG. 7 is a top view illustrating the configuration of the photometry unit of the automatic analyzer according to the second embodiment. The second embodiment shown in FIG. 7 differs from the first embodiment in FIG. 3 in that the light source 71a is replaced, the shield plate 72 is removed, and the wavelength separation of the light incident on the diffraction grating 76 is different. A position detector 80 that detects zero-order light that is not performed, and a correction unit 81 that is a correction unit that corrects a positional deviation of the light from the optical axis 70 in the light source 71a based on position information from the position detector 80 is additionally provided. This is the point. Of the units constituting the second embodiment, the same units as those of the first embodiment are denoted by the same reference numerals, and the description thereof is omitted or simplified.

  The photometric unit 13a includes a light source 71a, first and second condenser lenses 73 and 74, a slit 75, a diffraction grating 76, a photodetector 77, a signal processing unit 78, a position detector 80, and a correction unit 81. Is done.

  The light source 71 a includes a filament 712 a that is disposed on the optical axis 70 and emits light for irradiating the reaction container 3. Since the filament 712a is condensed in the reaction container 3 by the first condenser lens 73, the filament 712a is formed in a size included in the mixed liquid stored in the reaction container 3. The light source 71a is periodically replaced, and is attached so that the central axis of the filament 712a is orthogonal to the optical axis 70 at the time of replacement.

  The position detector 80 includes a plurality of one-dimensionally arranged photodiodes that detect zero-order light emitted from the diffraction grating 76 by irradiation of light from the light source 71a. Then, the position of the filament 712a of the light source 71a in the L1 direction and the L2 direction of the optical axis 70 is detected from the position of the photodiode that has detected the 0th order light.

  The correction unit 81 is provided to correct the positional deviation of the light from the light source 71a with respect to the optical axis 70 based on the position information detected by the position detector 80, and the filament 712a of the light source 71a is L1 from the optical axis 70. It is comprised by the determination part 82 which determines whether it has shifted | deviated to the direction or L2 direction, the refracting plate 83 which permeate | transmits the light from the light source 71a so that refraction is possible, and the drive part 84 which rotationally drives this refracting plate 83.

  The determination unit 82 obtains the distance between the filament 712a and the optical axis 70 in the L1 direction and the L2 direction of the optical axis 70 based on the position information detected by the position detector 80, and the filament 712a is obtained from the obtained distance information. It is determined whether or not the optical axis 70 is deviated. When the filament 712a is deviated from the optical axis 70, the light from the emission center of the filament 712a is converted to the optical axis based on the obtained distance information and the preset thickness and refractive index information of the refracting plate 83. A correction value that is an angle of the refracting plate 83 for moving upward is calculated.

  The refracting plate 83 is disposed between the light source 71a and the shielding plate 72 and is made of a flat glass material that transmits light from the light source 71a so as to be able to be refracted. When the incident surface and the exit surface are set at a reference angle perpendicular to the optical axis 70, the light incident from the emission center of the filament 712a is caused to travel straight. Further, when the angle is set to other than the reference angle, the light incident from the emission center of the filament 712a is refracted and translated with respect to the incident light.

  Based on the correction value information from the determination unit 82, the drive unit 84 moves the refracting plate 83 around the rotation axis arranged perpendicular to the spectrum surface of the diffraction grating 76 in the direction of the arrow R1 and the direction of R1. Rotates in the direction of arrow R2, which is the opposite direction.

  4 may be arranged between the light source 71a and the refractive plate 83 or between the refractive plate 83 and the first condenser lens 73.

  Hereinafter, an example of the operation of the photometry unit 13a will be described with reference to FIGS.

  FIG. 8 is a flowchart showing the operation of the photometry unit 13a. The operation shown below is executed before the analysis of the inspection item is started for each test sample set on the test sample information setting screen of the display unit 42.

  When an operation for analyzing a test item is performed for each test sample from the operation unit 50, the photometry unit 13a starts operation (step S1).

  The light source 71a emits light. The first condenser lens 73 condenses the light transmitted through the refracting plate 83 set at, for example, 90 ° with respect to the optical axis 70 in the reaction vessel 3. The second condenser lens 74 condenses the light collected by the first condenser lens 73 in the slit 75. The diffraction grating 76 emits zero-order light out of the light incident through the slit 75 to the position detector 80. The position detector 80 detects the position of the filament 712a in the L1 direction and the L2 direction of the optical axis 70 from the zero-order light emitted from the diffraction grating 76, and outputs the detected position information to the determination unit 82 (step S2). ).

  In addition, you may implement so that the 0th-order light of the light which permeate | transmitted between the two adjacent reaction containers 3 with the light which permeate | transmitted the refractive plate 83 may be detected with the position detector 80. FIG.

  The determination unit 82 obtains the distance between the filament 712a and the optical axis 70 in the L1 direction or the L2 direction based on the position information output from the position detector 80, and the filament 712a is separated from the optical axis 70 from the obtained distance information. It is determined whether or not there is a deviation.

  If the distance between the filament 712a and the optical axis 70 is out of the allowable range (Yes in step S3), it is determined that the filament 712a is displaced from the optical axis 70 in the L1 direction or the L2 direction, and the process proceeds to step S4. To do. If the distance between the filament 712a and the optical axis 70 is within the allowable range (No in step S3), it is determined that the position of the filament 712a is within the normal range, and the process proceeds to step S6.

  After “Yes” in step S3, the determination unit 82 corrects the position of the light from the light source 71a based on the obtained distance information and the preset thickness and refractive index information of the refracting plate 83. Then, a correction value that is an angle of the refracting plate 83 that moves the light from the emission center of the filament 712a onto the optical axis 70 is calculated (step S4). Thereafter, the correction value information is output to the drive unit 84.

  The drive unit 84 rotates the refracting plate 83 based on the correction value information from the determination unit 82 (step S5). Thereby, the light from the emission center of the filament 712a is translated onto the optical axis 70, and the positional deviation of the light from the light source 71a can be corrected.

  Here, as shown in FIG. 9, when the filament 712 a is out of the distance D from the optical axis 70 in the L1 direction, for example, the drive unit 84 rotates the refracting plate 83 by an angle θ from the reference angle to the R1 direction. As a result, the light from the emission center of the filament 712 a that is a distance D away from the optical axis 70 is translated onto the optical axis 70 by the refracting plate 83.

  After “No” in step S3 or step S5, the photometry unit 13a ends the correction operation (step S6). Thereafter, an operation for analyzing each inspection item is started.

  According to the second embodiment of the present invention described above, the position of the filament 712a in the L1 direction and the L2 direction of the optical axis 70 is detected from the 0th order light emitted from the diffraction grating 76 by the light irradiation from the light source 71a. Based on the position information from the position detector 80, the distance between the filament 712a and the optical axis 70 in the L1 direction or the L2 direction is obtained, and the filament 712a is displaced from the optical axis 70 in the L1 direction and the L2 direction from the obtained distance information. It can be determined whether or not.

  When the filament 712a is displaced from the optical axis 70 in the L1 direction or the L2 direction, the light from the light emission center of the filament 712a can be moved onto the optical axis 70 by rotating the refractive plate 83. Thereby, it is possible to prevent a decrease in wavelength accuracy due to the deformation of the filament 712a, and it is possible to prevent deterioration of analysis data.

  The third embodiment of the photometric part of the automatic analyzer according to the present invention will be described below with reference to FIGS.

  FIG. 10 is a top view illustrating the configuration of the photometry unit of the automatic analyzer according to the third embodiment. The third embodiment shown in FIG. 10 is different from the second embodiment shown in FIG. 3 in the correction means for correcting the positional deviation of the light from the optical axis 70 in the light source 71a based on the position information from the position detector 80. This is a point replaced with the correction unit 81b. Of the units constituting the third embodiment, the same units as those of the second embodiment are denoted by the same reference numerals, and description thereof is omitted or simplified.

  The photometric unit 13b includes a light source 71a, first and second condenser lenses 73 and 74, a slit 75, a diffraction grating 76, a photodetector 77, a signal processing unit 78, a position detector 80, and a correction unit 81b. Is done.

  The correction unit 81b is provided to correct the positional deviation of the light from the light source 71a with respect to the optical axis 70 based on the position information detected by the position detector 80, and the filament 712a of the light source 71a is L1 from the optical axis 70. It is comprised by the drive part 84b which moves and drives the determination part 82b and the light source 71a which determine whether it has shifted | deviated to the direction or the L2 direction.

  The determination unit 82b obtains the distance between the filament 712a and the optical axis 70 in the L1 direction or the L2 direction based on the position information detected by the position detector 80, and the filament 712a is separated from the optical axis 70 from the obtained distance information. It is determined whether or not there is a deviation. When the filament 712a is displaced from the optical axis 70 in the L1 direction or the L2 direction, a correction value for moving the filament 712a onto the optical axis 70 is calculated based on the obtained distance information.

  The drive unit 84b moves the light source 71a in the L1 direction and the L2 direction based on the correction value information from the determination unit 82b. Then, the light from the light source 71 a is moved onto the optical axis 70.

  Hereinafter, an example of the operation of the photometry unit 13b will be described with reference to FIGS.

  FIG. 11 is a flowchart showing the operation of the photometry unit 13b. This is executed before starting analysis of inspection items for each test sample set on the test sample information setting screen of the display unit 42.

  When an operation for analyzing a test item is performed for each test sample from the operation unit 50, the photometry unit 13b starts an operation (step S11).

  The light source 71a emits light. The first condenser lens 73 condenses the light from the light source 71a in the reaction container 3 or between two adjacent reaction containers 3. The second condenser lens 74 condenses the light transmitted through the reaction container 3 or the light transmitted between the reaction containers 3 in the slit 75. The diffraction grating 76 emits zero-order light out of the light incident through the slit 75 to the position detector 80.

  The position detector 80 detects the position of the filament 712a in the L1 direction and the L2 direction of the optical axis 70 from the zero-order light from the diffraction grating 76 (step S12). Then, the detected position information is output to the determination unit 82b of the correction unit 81b.

  The determination unit 82b obtains the distance between the filament 712a and the optical axis 70 in the L1 direction or the L2 direction based on the position information output from the position detector 80, and the filament 712a is separated from the optical axis 70 from the obtained distance information. It is determined whether or not there is a deviation.

  If the distance between the filament 712a and the optical axis 70 is out of the allowable range (Yes in step S13), it is determined that the filament 712a is displaced from the optical axis 70, and the process proceeds to step S14. When the distance between the filament 712a and the optical axis 70 is within the allowable range (No in step S13), it is determined that the position of the filament 712a is within the normal range, and the process proceeds to step S16.

  After “Yes” in Step S13, the determination unit 82b calculates a correction value for moving the filament 712a onto the optical axis 70 based on the obtained distance information (Step S14). Thereafter, the correction value information is output to the drive unit 84b.

  The drive unit 84b moves the light source 71a based on the correction value information from the determination unit 82b (step S15). As a result, the filament 712a is moved onto the optical axis 70.

  After “No” in step S13 or step S15, the photometry unit 13b ends the correction operation (step S16). Thereafter, an operation for analyzing each inspection item is started.

  According to the third embodiment of the present invention described above, the position of the filament 712a in the L1 direction and the L2 direction of the optical axis 70 is detected from the zero-order light emitted from the diffraction grating 76 by the light irradiation from the light source 71a. Based on the position information from the position detector 80, the distance between the filament 712a and the optical axis 70 in the L1 direction or the L2 direction is obtained, and the filament 712a is displaced from the optical axis 70 in the L1 direction and the L2 direction from the obtained distance information. It can be determined whether or not.

  When the filament 712a is displaced in one direction from the optical axis 70 in the L1 direction or the L2 direction, the filament 712a can be set on the optical axis 70 by moving the light source 71a in the other direction. Thereby, it is possible to prevent a decrease in wavelength accuracy due to the deformation of the filament 712a, and it is possible to prevent deterioration of analysis data.

3 Reaction container 70 Optical axis 71, 71a Light source 72 Shielding part 711 Center axis 721 Opening part

Claims (3)

An automatic analyzer that irradiates a reaction container containing a mixed solution of a test sample and a reagent and radiates light through the mixed solution to disperse the light with a diffraction grating and detects the spectrum to measure the mixed solution In
A light source wherein a filament as a light source for irradiating the reaction vessel was closed, the filament is arranged to be positioned on the optical axis,
Position detecting means for detecting zero-order light emitted from the diffraction grating by irradiation of light from the light source and detecting the position of the filament;
Correction means for correcting a positional deviation of the light from the light source with respect to the optical axis based on the position information detected by the position detection means;
Automatic analyzer characterized by comprising. The correction means includes
A refracting plate disposed between the light source and the reaction vessel so as to be parallel to the outgoing light with respect to the incident light from the light source; and
Driving means for rotating the refractive plate,
2. The automatic analyzer according to claim 1 , wherein correction is performed by rotating the refracting plate to translate the center of light from the light source on the optical axis . The correction means includes
Driving means for moving the light source in a direction other than a direction parallel to the optical axis;
The automatic analyzer according to claim 1, wherein correction is performed by moving the light source to a position where the filament is on the optical axis .

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