JP5417845B2 - Blood collection tube - Google Patents

Description

  The present invention relates to a blood collection tube for storing blood collected in a tube body.

  Conventionally, blood is collected from a living body such as a human for the purpose of diagnosis and the like, and analysis of various components in the blood has been performed as a blood test. In order to collect blood from a living body, a blood collection tube is used in addition to a syringe. In this blood collection tube, a tube body whose one end is opened and the other end is closed is hermetically closed by a rubber stopper or the like through which a blood collection needle can be inserted. The internal space of the tube body closed by a rubber plug or the like is kept in a reduced pressure state with respect to atmospheric pressure. Further, if necessary, a drug such as a serum separating agent or a coagulant is enclosed in the tube body.

  When the blood collection tube is attached to the blood collection needle holder to which the blood collection needle is attached, the blood collection needle passes through the rubber stopper, and the blood of the living body is sucked through the blood collection needle into the internal space of the reduced pressure state. When an appropriate amount of blood is sucked into the tube body, the blood collection tube is removed from the blood collection needle holder. When the blood collection tube is removed, the blood collection needle is withdrawn from the rubber stopper, and the puncture passage by the blood collection needle is sealed fluid-tight by the elasticity of the rubber. After blood collection, the blood collection tube is subjected to a process such as centrifugation as it is and then opened, blood or serum in the blood collection tube is collected, and various blood tests are performed (Patent Document 1).

  Among the blood collection tubes described above, there is a type in which the tube body is hermetically closed using a gas barrier film instead of a rubber stopper. A rubber piece is attached to a part of the film in order to ensure liquid-tightness after the needle is removed. A blood collection needle penetrates the rubber piece, and blood is sucked into the tube body through the blood collection needle as described above. Moreover, after processing, such as centrifugation, a pipe | tube main body is opened by peeling a film, and the blood or serum in a pipe | tube main body is extract | collected (patent document 2).

  In addition, there is a blood collection tube provided with a partition member that can be perforated at a position below the back surface of the rubber stopper in the main body of the blood collection tube. The partition member is pierced by a sharp member such as a nozzle or the like at the time of blood collection and dispensing. By this partition member, scattering of blood at the time of opening is prevented (Patent Document 3).

  In addition, there is a type of blood collection tube in which a skirt portion covering the outer periphery of the tube main body is provided at the flange portion of the rubber plug. Also in this blood collection tube, the splash of blood splashed from the tube body when removing the rubber stopper adheres to the inner surface side of the skirt portion, so that the splashed blood splash does not contaminate the operator's hand and surrounding environment. (Patent Document 4).

  In addition, there is a type of blood collection tube in which a boundary portion between the rubber stopper and the tube body is covered with a film. When the rubber stopper is removed, the film is partially broken by being twisted with respect to the tube body together with the rubber stopper. When the rubber stopper is removed, the blood splash that has jumped out from the tube body adheres to the inner surface of the film, so that the splashed blood splash does not contaminate the operator's hand or the surrounding environment (Patent Document 5).

  Some of the blood collection tubes described above have a sheet stretched on the upper surface of a rubber stopper. Whether the sheet has been used or sterilized can be determined based on the presence or absence of the sheet and whether or not there is a trace of a needle stuck in the sheet (Patent Document 6).

  In addition, in some of the blood collection tubes described above, the opening of the tubular container is hermetically closed with a sheet member, and a cover member is provided on the outer surface of the sheet member. The cover member is twisted with respect to the tubular container to break the sheet member, and is fitted to the opening of the tubular container after the sheet member is broken. As a result, the tubular container can be closed again with the cover member even after the blood collection tube that is airtightly closed with the sheet member is opened instead of the rubber stopper (Patent Document 7).

  Further, there has been proposed an opening device that opens a blood collection tube whose tube body is airtightly closed by a sheet after blood collection. This plugging device opens a blood collection tube by inserting a rubber piece or the like attached to a sheet of the blood collection tube with a holding pin, and then a punching cutter punching around the rubber piece (Patent Document 8). .

JP-A-8-322819 JP 2005-261965 A JP 2008-173218 A JP 2001-276023 A JP 2002-587 A Japanese Patent Laying-Open No. 2005-296122 Japanese Patent No. 3533023 JP 2008-184168 A

  In the type of blood collection tube described above, the type in which the tube body is hermetically closed with a rubber plug, after collecting blood from the tube body, the tube body is again closed with a rubber plug to preserve the remaining blood. There is an advantage that you can. On the other hand, although there is a device that automatically opens the rubber stopper of the blood collection tube, most of the opening devices introduced in facilities such as hospitals and examination centers punch a sheet as disclosed in Patent Document 8. In a facility where such a so-called sheet-type blood collection tube opener is introduced, another opener is used to automate the opening of the rubber plug-type blood collection tube. There is a problem that the cost for opening a large amount of rubber stopper type blood collection tubes is high.

  On the other hand, the sheet-type blood collection tube can be automatically opened using the opening device already installed in many facilities. In addition, since the seal can be manually opened by peeling off the seal, it can be immediately adopted even when blood is manually collected from a blood collection tube, such as in a facility where the opening device is not introduced. . However, when the seal is peeled off, there is a drawback that blood adhering to the sheet easily adheres to the operator's hand. Moreover, when peeling a sheet | seat, there also exists a fault that a blood droplet may fly out as mentioned above from the clearance gap between a sheet | seat and a pipe | tube main body. Furthermore, since the blood collection tube cannot be resealed by the peeled sheet, there is a drawback that blood or the like leaks if the blood collection tube is laid down after opening.

  For example, in the blood collection tube described in Patent Document 3, blood collection is performed by inserting a blood collection needle into the partition member, and after the needle is pulled out, the small hole formed in the partition member is elastically or the like. close up. By this partition member, scattering of blood at the time of opening is prevented.

  However, there is a problem in that the nozzle used when dispensing blood from the blood collection tube after opening is limited to a sharp member that can pierce the partition member. Generally, a nozzle such as a pipette or a dispensing nozzle such as an automatic inspection apparatus is not assumed to pierce such a partition member, and the tip thereof is not always sharp. Therefore, there is a problem that the partition member cannot always be pierced by a pipette nozzle or a dispensing nozzle of an automatic inspection device that is widely used. In other words, in the blood collection tube described in Patent Document 3, there is a problem that a dispensing instrument such as a pipette that can be used is limited or a dedicated instrument is required.

  In addition, when the inner space of the blood collection tube is partitioned by an airtight partition member, the bottom side becomes more airtight than the partition member. There is a risk.

  The present invention has been made in view of these circumstances, and its purpose is to have the advantages of a sheet-type blood collection tube, and there is no problem of blood scattering or leakage, and blood dispensing, etc. It is to provide a blood collection tube that can use a general-purpose instrument.

  (1) A blood collection tube according to the present invention has an open first end, a tube main body capable of storing blood in an internal space, and a sheet bonded to the first end of the tube main body to close the opening And a hemostasis valve that is disposed in the tube body so as to partition the first end side and the opposite side with respect to the longitudinal direction of the tube body, and is openable in the longitudinal direction by elastic deformation. Are provided.

  The blood collection tube according to the present invention is attached to, for example, a well-known blood collection needle holder, and blood is collected in the internal space of the tube body through the blood collection needle by the blood collection needle penetrating the sheet and opening the hemostasis valve. Is. A sheet is joined to the first end of the tube body, and the opening of the tube body is closed in a liquid-tight manner. A hemostasis valve is arranged inside the tube main body at a predetermined distance from the first end sheet. The separation distance between the sheet and the hemostasis valve is set such that the needle used for blood collection can penetrate the sheet and the tip of the needle can reach the hemostasis valve sufficiently.

  The internal space of the tube body is partitioned by a hemostasis valve. The internal space (first chamber) on the first end side and the internal space (second chamber) on the opposite side with respect to the longitudinal direction of the tube main body are liquid-tightly partitioned by a hemostasis valve. The needle penetrating the sheet elastically deforms the hemostasis valve or pierces the hemostasis valve, and the tip of the needle reaches the opposite internal space (second chamber). And the blood which flows out from the front-end | tip of the needle | hook is stored in the internal space (2nd chamber) of the other side, This stored blood is stored in the internal space (1st chamber) of the 1st end side by the hemostatic valve. It does not flow. Even if the needle pierces the hemostasis valve, blood does not leak from the piercing hole of the needle due to the elasticity of the hemostasis valve.

  After blood collection, when the sheet is peeled from the tube body and blood or serum is dispensed, the blood stored in the internal space on the opposite side (second chamber) is removed from the internal space on the first end side by the hemostasis valve. Since it does not flow into the (first chamber), blood does not leak from the tube body even if the tube body is laid down. In addition, even if centrifugation is performed or the blood collection tube is shaken before the sheet is peeled off, the blood in the tube body does not adhere to the sheet by the hemostasis valve. Furthermore, blood does not adhere to the operator's finger or the like, and blood does not scatter outside the tube body.

  After the sheet is peeled from the tube body, a pipette nozzle or the like is inserted into the tube body from the first end side. When the tip of the nozzle comes into contact with the hemostasis valve, the hemostasis valve is elastically deformed and opened. Through this opening, the tip of the nozzle reaches the inner space (second chamber) on the opposite side, and blood or serum is dispensed from the tube body by operating the pipette. Further, even if the sheet is not peeled off from the tube body, a tip of the nozzle may be inserted into the tube body by inserting a pipette nozzle or the like into a needle puncture mark formed on the sheet to make a hole.

  (2) Examples of the hemostasis valve include a membrane having a thin thickness along the longitudinal direction of the tube body and having a slit penetrating the membrane in the longitudinal direction of the tube body.

  (3) Examples of the hemostasis valve include a funnel shape protruding along the longitudinal direction of the tube body and having a hole capable of expanding the diameter at the tip of the funnel shape.

  (4) As the hemostatic valve, there is a duckbill type.

  (5) The hemostasis valve may be capable of being pierced with a needle and capable of liquid-tightly closing a puncture passage formed by the needle after the needle is removed.

  (6) The tube main body may be held in an airtight state by the sheet and the internal space may be in a reduced pressure state with respect to atmospheric pressure.

  For example, the internal space of the tube main body is maintained in a reduced pressure state for a long time by the gas barrier sheet. As a result, a blood collection tube whose internal space is decompressed can be realized easily and inexpensively.

  (7) The tube main body is divided into the first chamber on the first end side and the second chamber on the opposite side by the hemostasis valve, and is used as the blood collected in the second chamber. It is assumed that

  According to the blood collection tube according to the present invention, since the first end of the tube body is closed by the sheet, a widely used unplugging device can be used and the sheet can be opened manually. The advantages of blood collection tubes.

  In addition, since the internal space of the tube body is partitioned by the hemostasis valve, the blood stored in the internal space (second chamber) opposite to the internal space (first chamber) on the first end side is the first end. It does not flow into the internal space (first chamber) on the side. Thereby, even if a sheet | seat peels or a hole is pierced, the scattering and leakage of blood are prevented.

  When the sheet is peeled from the tube body and blood or serum is dispensed, the hemostasis valve is elastically deformed and opened by the pipette nozzle inserted into the tube body from the first end side. When dispensing blood or serum from the main body, a widely used dispensing device can be used. Further, without peeling the sheet from the pipe body, the nozzle is inserted into the pipe body by making a hole in the sheet with a pipette nozzle or the like.

  Hereinafter, preferred embodiments of the present invention will be described. In addition, this embodiment is only one embodiment of this invention, and it cannot be overemphasized that an embodiment can be changed in the range which does not change the summary of this invention.

[Explanation of drawings]
FIG. 1 is a perspective view showing an external configuration of a blood collection tube 10 according to the first embodiment of the present invention. FIG. 2 is an exploded perspective view of the blood collection tube 10. FIG. 3 is a longitudinal sectional view of the blood collection tube 10. FIG. 4 is a longitudinal sectional view showing a state in which blood is collected by the blood collection tube 10. FIG. 5 is a longitudinal sectional view showing a state after blood collection by the blood collection tube 10. FIG. 6 is a longitudinal sectional view showing a state where the blood collection tube 10 after blood collection is manually opened. FIG. 7 is a longitudinal sectional view showing a state in which blood 102 is dispensed from the blood collection tube 10 after opening. FIG. 8 is a longitudinal cross-sectional view showing a state in which a hole is made in the sheet 12 by the nozzle 16 and blood 102 is dispensed from the blood collection tube 10. FIG. 9A is an exploded perspective view showing the hemostatic valve 40 according to the first modification, and FIG. 9B is a plan view showing the hemostatic valve 40. FIG. 10A is a plan view showing a hemostasis valve 50 according to a second modification, and FIG. 10B is a cross-sectional view showing the hemostasis valve 50 along the IX-IX cutting line. FIG. 11A is a plan view showing a hemostasis valve 60 according to a third modification, and FIG. 11B is a cross-sectional view showing the hemostasis valve 60 along the line XX. FIG. 12 is a cross-sectional view showing a state where the hemostasis valve 60 is opened by the nozzle 16. FIG. 13A is a plan view showing a hemostasis valve 70 according to a fourth modification, and FIG. 13B is a cross-sectional view showing the hemostasis valve 70 along the XII-XII cutting line. FIG. 14 is a cross-sectional view showing a state where the hemostasis valve 70 is opened by the nozzle 16.

  Hereinafter, embodiments of the present invention will be described. In this embodiment, when simply referred to as “upper side” or “lower side”, the axial direction 101 in FIG. 2 is the vertical direction, the upper side in FIG. 2 is “upper side”, and the lower side in FIG. The side is “lower”.

(Schematic configuration of blood collection tube 10)
As shown in FIGS. 1 to 3, the blood collection tube 10 according to the present embodiment is disposed in a tube main body 11, a sheet 12 that closes the open end 20 of the tube main body 11, and an internal space of the tube main body 11. The hemostatic valve 13 is the main component.

(Tube body 11)
As shown in FIG. 2, the tube body 11 has a substantially cylindrical shape. The tube body 11 is closed on the bottom as a hemispherical bottom. The upper side of the tube body 11 is opened as an open end 20. Therefore, a liquid such as blood flows into or out of the internal space of the tube main body 11 from the open end 20, and the liquid such as blood can be stored in the internal space. The open end 20 of the tube body 11 corresponds to the first end in the present invention.

  The open end 20 of the tube body 11 forms a plane orthogonal to the axial direction 101 of the cylindrical tube body 11. The plane of the open end 20 functions as a joint surface with the sheet 12. Here, the side wall of the tube main body 11 is bent, and the plane formed by the open end 20 has an increased bonding area with the sheet 12.

  For example, the tube body 11 can be molded using polyethylene terephthalate as a main raw material, but other known materials may be used. The tube body 11 is preferably gas barrier because the open end 20 is closed by the sheet 12 and the internal space is kept airtight in a reduced pressure state relative to the atmospheric pressure. This gas barrier property is not necessarily realized by a single raw material, and may be realized by laminating a gas barrier film or the like on the outer surface or the inner surface of the tube body 11.

  Although not described in detail in the present embodiment, a known drug such as a serum separating agent or a coagulation promoter may be injected into the internal space of the tube body 11.

(Sheet 12)
As shown in FIGS. 1 to 3, the sheet 12 is joined to the open end 20 of the tube body 11 to close the open end 20. In the state where the sheet 12 is joined, the internal space of the tube body 11 is maintained liquid-tight and air-tight. By joining the sheet 12 under a reduced pressure atmosphere, the internal space of the tube main body 11 is brought into a reduced pressure state.

  As shown in FIG. 2, the sheet 12 is a disk-shaped thin film having an outer diameter equivalent to the outer diameter of the open end 20. The sheet 12 has a gas barrier property in order to keep the internal space of the tube body 11 airtight. The sheet 12 can be pierced by a blood collection needle 14 (see FIG. 4) attached to the blood collection tube holder. Such a sheet | seat 12 is implement | achieved by the laminated film of aluminum and polyethylene, for example, However, Other resin sheets, composite sheets, etc. may be used. The joining of the opening end 20 of the tube body 11 and the sheet 12 is realized by heat welding or the like.

(Hemostatic valve 13)
As shown in FIGS. 1 to 3, the hemostatic valve 13 is disposed in the internal space of the tube body 11. The hemostasis valve 13 has a disk shape with an outer diameter slightly larger than the inner diameter of the tube main body 11, and the front and back surfaces of the tube main body 11 are fitted to the annular groove 21 formed on the inner wall of the tube main body 11. The tube body 11 is disposed at a predetermined position in the internal space of the tube body 11 in a posture orthogonal to the axial direction 101. The axial direction 101 of the tube body 11 corresponds to the longitudinal direction of the tube body in the present invention.

  As shown in FIG. 3, the hemostatic valve 13 divides the internal space of the tube body 11 into a first chamber 22 on the open end 20 side and a second chamber 23 on the bottom side. The arrangement of the hemostasis valve 13 with respect to the axial direction 101 of the tube body 11 is set in consideration of the distance from the seat 12 and the capacity of the second chamber 23. Specifically, the hemostasis valve 13 is disposed in a range where the tip of the blood collection needle 14 penetrating the sheet 12 can be reached. In addition, the hemostasis valve 13 is arranged in a range in which a desired amount of blood can be collected in the second chamber 23.

  The hemostasis valve 13 is a thin film along the axial direction 101 of the tube body 11. Further, the peripheral edge portion of the hemostasis valve 13 is made thick, thereby increasing the strength of the hemostasis valve 13 and strengthening the above-described concave groove 21 of the tube body 11 and the peripheral edge portion of the hemostasis valve 13. Engaged. Such a hemostasis valve 13 is made of an elastic member through which the blood collection needle 14 can be pierced in a thin film portion other than the peripheral portion. This elastic member is capable of liquid-tightly closing the puncture passage formed by the blood collection needle after the blood collection needle 14 is removed. Such a characteristic of the elastic member is realized by a known rubber such as natural rubber, isopropylene rubber, or silicon rubber. Moreover, even if it is other than rubber | gum, it is implement | achieved also by elastic materials, such as a vulcanized elastomer and a thermoplastic elastomer.

  The hemostatic valve 13 has a Y-shaped slit 31 formed in the vicinity of the center thereof. The Y-shaped slit 31 is formed so that the points where the three slits extending in the radial direction intersect with each other coincide with the center of the disc-shaped hemostatic valve 13. When provided in the space, a point where the slits in the three directions intersect is arranged on the axial direction 101. The slit 31 penetrates the hemostasis valve 13 in the thickness direction.

  The slit 31 maintains a state in which each slit is closed when no external force is applied. In this state, the first chamber 22 and the second chamber 23 partitioned by the hemostasis valve 13 are partitioned in a liquid-tight manner. The In other words, the hemostasis valve 13 is closed as long as no external force is applied, and blood does not flow out from the second chamber 23 to the first chamber 22. On the other hand, when an external force acts in the axial direction 101, the slit 31 is elastically deformed in the axial direction 101, and the hemostasis valve 13 is opened. In this state, blood can flow between the first chamber 22 and the second chamber 23. In addition, the hemostasis valve 13 can be opened due to the elastic deformation of the slit 31 due to the pressure difference between the first chamber 22 and the second chamber 23. Therefore, when the tube body 11 provided with the hemostasis valve 13 is placed in a reduced pressure atmosphere, the hemostasis valve 13 is opened and gas can flow from the second chamber 23 to the first chamber 22.

[How to use the blood collection tube 10]
Below, the usage method of the blood collection tube 10 is demonstrated.

(Blood collection)
As shown in FIG. 4, the blood collection needle 10 is attached to a known blood collection needle holder so that the blood collection needle 14 penetrates the sheet 12. In FIG. 4, the blood collection needle holder is omitted, and only a part of the blood collection needle 14 is shown. The rubber cover 15 surrounding the blood collection needle 14 is in close contact with the periphery of the through hole formed in the sheet 12 by the blood collection needle 14 being penetrated, and the sheet 12 penetrates in the state where the blood collection needle 14 is penetrated. Airtightness around the hole is secured.

  The tip of the blood collection needle 14 penetrating the sheet 12 reaches the hemostasis valve 13 and elastically deforms the slit 31 to enter the second chamber 23. Then, blood is sucked into the second chamber 23 through the blood collection needle 14 by the suction force generated by the reduced pressure state of the second chamber 23. The sucked blood 102 is stored in the second chamber 23. When a predetermined amount of blood 102 is sucked into the second chamber 23, the blood collection tube 10 is removed from the blood collection needle holder, and the blood collection needle 14 is withdrawn from the sheet 12 accordingly.

  As shown in FIG. 5, when the blood collection needle 14 is pulled out from the hemostasis valve 13, the slit 31 is elastically restored and the hemostasis valve 13 is closed. Further, when the blood collection needle 14 is pulled out from the hemostasis valve 13, the peripheral portion of the slit 31 wipes off the blood adhering to the blood collection needle 14. The through hole formed by the blood collection needle 14 in the sheet 12 is not blocked even after the blood collection needle 14 is pulled out, but the second chamber 23 is liquid-tightly closed by the hemostasis valve 13, so Blood 102 does not flow out to the first chamber 22 side. After blood collection, processing such as centrifugation is performed on the blood 102 of the blood collection tube 10 as necessary. For example, by performing centrifugation, the blood 102 in the blood collection tube 10 is separated into a serum component and other blood cell components.

  Even if the distal end of the blood collection needle 14 that has penetrated the sheet 12 penetrates the hemostasis valve 13 without elastically deforming the slit 31 of the hemostasis valve 13, as described above, Since the puncture passage formed by the blood collection needle 14 after being removed can be liquid-tightly closed, the second chamber 23 is liquid-tightly closed as described above.

(Opening manually)
As shown in FIG. 6, when the blood collection tube 10 is manually opened in order to collect blood 102 and serum components of the blood collection tube 10, the sheet 12 is peeled from the tube body 11. Although not shown in each figure, a tongue piece or the like for gripping the sheet 12 may be provided integrally with the sheet 12 in order to facilitate the peeling operation of the sheet 12. As described above, since the blood 102 does not flow out from the second chamber 23 to the first chamber 22 side by the hemostasis valve 13, even if the blood collection tube 10 is subjected to centrifugation or the like after blood collection, the sheet 12 Blood 102 does not adhere. Moreover, since the peripheral part of the slit 31 wipes off the blood adhering to the blood collection needle 14, the blood 12 does not adhere to the sheet 12 via the blood collection needle 14. Therefore, even if the sheet 12 is peeled manually, the blood 102 does not adhere to the operator's finger or the blood 102 does not scatter from the open end 20.

  As shown in FIG. 7, after the sheet 12 is peeled from the open end 20 of the tube body 11, the pipette nozzle 16 is inserted from the open end 20. The tip of the nozzle 16 reaches the hemostasis valve 13 and elastically deforms the slit 31 to enter the second chamber 23. When the tip of the nozzle 16 enters the blood 102 or serum in the second chamber 23, the blood 102 or serum stored in the second chamber 23 is sucked out by the pipette and dispensed into a desired container. When the nozzle 16 is pulled out from the tube main body 11, the slit 31 is elastically restored and the hemostasis valve 13 is closed. Therefore, the remaining blood 102 does not flow out of the second chamber 23 of the tube body 11 even if the open end 20 of the tube body 11 is not re-plugged.

  Although not shown in the drawing, the blood collection tube 10 may be opened using a plugging device in order to collect blood 102 and serum components of the blood collection tube 10. The opening device opens the blood collection tube 10 by breaking the sheet 12. Moreover, the tube main body 11 after opening may be mounted in an automatic analyzer as it is, for example. When the dispensing nozzle of the automatic analyzer is inserted into the tube body 11 and contacts the hemostasis valve 13, the slit 31 is elastically deformed and enters the second chamber 23 in the same manner as the nozzle 16 described above. The blood 102 or serum stored in the second chamber 23 is dispensed by the dispensing nozzle.

  Further, the blood collection tube 10 according to the present embodiment may be used after the blood collection without peeling the sheet 12 from the tube body 11 as described above. Specifically, as shown in FIG. 8A, the nozzle 14 is inserted into a puncture passage formed by the blood collection needle 14 penetrating the sheet 12, and the puncture passage is expanded. As shown in FIG. 8 (B), by further inserting the nozzle 14, the nozzle 14 is inserted into the tube main body 11 and elastically deforms the hemostatic valve 13 to reach the blood 102 stored in the second chamber 23. . In this way, blood 102 can be dispensed from the tube body 11 without peeling the sheet 12 from the tube body 11 after blood collection.

[Operational effects of this embodiment]
According to the blood collection tube 10 according to the present embodiment, since the open end 20 of the tube body 11 is closed by the sheet 12, a widely used opening device can be used and the tube can be opened manually. The sheet-type blood collection tube has the advantage of being able to.

  In addition, since the internal space of the tube body 11 is partitioned by the hemostasis valve 13, the blood 102 stored in the second chamber 23 does not flow into the first chamber 22. Thereby, when the sheet 12 is peeled off, the blood 102 does not scatter and the blood 102 does not adhere to the operator's finger or the like. Furthermore, even if the tube body 11 is laid down after the sheet 12 is peeled off, the blood 102 does not leak from the tube body 11.

  When the sheet 12 is peeled from the tube body 11 and blood 102 or serum is dispensed, the hemostasis valve 13 is elastically deformed by the pipette nozzle 16 inserted into the tube body 11 from the open end 20. Since it opens, when dispensing the blood 102 or serum from the pipe | tube main body 11, the dispensing instrument currently used widely can be used. Further, without peeling the sheet 12 from the tube body 11, the nozzle 16 is inserted into the tube body 11 by making a hole in the sheet 12 with a pipette nozzle 16 or the like.

[First Modification]
Below, the 1st modification of embodiment mentioned above is demonstrated. The first modification is different only in the configuration of the hemostasis valve 13, and the other configurations of the tube main body 11, the sheet 12, and the like are the same. Therefore, hereinafter, only the configuration of the hemostatic valve 40 different from the above-described hemostatic valve 13 will be described in detail, and description of the configuration of the other blood collection tube 10 will be omitted.

(Hemostatic valve 40)
As shown in FIG. 9, the hemostasis valve 40 includes a first hemostasis valve 41 and a second hemostasis valve 42. The first hemostasis valve 41 and the second hemostasis valve 42 are disposed in the inner space of the tube body 11 in the same manner as the hemostasis valve 13 described above in a state where they are stacked in close contact with each other.

  Each of the first hemostasis valve 41 and the second hemostasis valve 42 is a disc shape having an outer diameter slightly larger than the inner diameter of the tube main body 11, and is a thin film along the axial direction 101 of the tube main body 11. Further, both the first hemostasis valve 41 and the second hemostasis valve 42 are made of an elastic member through which a blood collection needle can be inserted.

  In the first hemostasis valve 41 and the second hemostasis valve 42, “+” shaped slits 43 and 44 are formed near the center thereof. Each of the slits 43 and 44 is formed such that the point where the four slits extending in the radial direction intersect with each other coincides with the center of the disc-shaped first hemostasis valve 41 or the second hemostasis valve 42. When the hemostasis valve 41 and the second hemostasis valve 42 are provided in the internal space of the tube body 11, the points where the four slits intersect with each other in the slits 43 and 44 are arranged on the axial direction 101. Each of the slits 43 and 44 penetrates the membrane of the first hemostasis valve 41 or the second hemostasis valve 42 in the thickness direction.

  The slit 43 formed in the first hemostasis valve 41 and the slit 44 formed in the second hemostasis valve 42 are different from each other in the four directions spreading radially. Therefore, in the state where the first hemostasis valve 41 and the second hemostasis valve 42 are laminated, the slit 43 and the slit 44 are located at intersections other than the intersections arranged at the centers of the first hemostasis valve 41 and the second hemostasis valve 42. Is not continuous in the thickness direction (axial direction 101) of the first hemostasis valve 41 and the second hemostasis valve 42. By such slits 43 and 44, reliable liquid tightness by the hemostasis valve 40 is realized. On the other hand, when an external force is applied in the axial direction 101, the slits 43 and 44 are elastically deformed and the hemostasis valve 13 is opened. Such a hemostasis valve 40 also provides the same effect as that of the above-described embodiment.

[Second Modification]
Below, the 2nd modification of embodiment mentioned above is demonstrated. The second modified example is different only in the configuration of the hemostasis valve 13, and the other configurations of the tube main body 11, the sheet 12, and the like are the same. Therefore, hereinafter, only the configuration of the hemostasis valve 50 different from the above-described hemostasis valve 13 will be described in detail, and the description of the configuration of the other blood collection tube 10 will be omitted.

(Hemostatic valve 50)
As shown in FIG. 10, the hemostasis valve 50 is a disc shape having an outer diameter slightly larger than the inner diameter of the tube main body 11, and is a thin film along the axial direction 101 of the tube main body 11. The hemostasis valve 50 is made of an elastic member through which the blood collection needle 14 can be pierced. Although not shown in the drawing, the hemostasis valve 50 is disposed in the internal space of the tube body 11 in the same manner as the hemostasis valve 13 described above.

  The hemostatic valve 50 is configured such that two thin films 51 and 52 partially overlap in the radial direction. The thin films 51 and 52 have a partial disk shape that is slightly wider than the semicircle with respect to the disk shape of the hemostasis valve 50, and the two thin films 51 and 52 are linear in the area larger than the semicircle. The portions including the edge portions 53 and 54 are arranged so as to overlap in the thickness direction (axial direction 101). The overlap between the two thin films 51 and 52 exerts a valve function between the edges 53 and 54.

  Specifically, in a state where no external force is applied, the thin films 51 and 52 maintain a state where the portions including the edge portions 53 and 54 are in close contact with each other, and the space between the edge portions 53 and 54 is liquid-tightly closed. The On the other hand, when an external force is applied in the axial direction 101, the thin films 51 and 52 are elastically deformed to create a gap between the portions including the edge portions 53 and 54, and the hemostasis valve 13 is opened. Such a hemostasis valve 50 also has the same effect as that of the above-described embodiment.

[Third Modification]
Below, the 3rd modification of embodiment mentioned above is demonstrated. The third modified example is different only in the configuration of the hemostasis valve 13, and the other configurations of the tube main body 11, the sheet 12, and the like are the same. Therefore, hereinafter, only the configuration of the hemostatic valve 60 different from the above-described hemostatic valve 13 will be described in detail, and description of the configuration of the other blood collection tube 10 will be omitted.

(Hemostatic valve 60)
As shown in FIG. 11, the hemostasis valve 60 has a funnel shape that protrudes along the axial direction 101 of the tube body 11, and has a hole 61 that can be expanded in diameter at the tip of the funnel shape. The hemostasis valve 60 is made of an elastic member through which the blood collection needle 14 can be pierced. Although not shown in the drawing, the hemostasis valve 60 is disposed in the internal space of the tube body 11 in the same manner as the hemostasis valve 13 described above with its funnel-shaped tip directed toward the bottom side of the tube body 11. Is done.

  The hemostatic valve 60 maintains a state where the hole 61 is not expanded in a state where no external force is applied. The hole 61 is set to have an inner diameter at which the blood 102 hardly flows due to the surface tension of the blood 102. Therefore, although the hemostatic valve 60 has a flow path in the axial direction 101 due to the hole 61, the blood 102 does not flow through the hole 61. That is, the hemostasis valve 60 is closed.

  As shown in FIG. 12, the hemostatic valve 60 guides the pipette nozzle 16 and the blood collection needle 14 inserted from the open end 20 side of the tube body 11 to the hole 61 due to its funnel shape. Then, by inserting the nozzle 16 or the like into the hole 61, the diameter of the hole 61 is expanded by elastic deformation. Thereby, the hemostatic valve 60 will be in an open state. Such a hemostasis valve 60 also provides the same effect as that of the above-described embodiment.

[Fourth Modification]
Below, the 4th modification of embodiment mentioned above is demonstrated. The fourth modified example is different only in the configuration of the hemostasis valve 13, and the other configurations of the tube main body 11, the sheet 12, and the like are the same. Therefore, hereinafter, only the configuration of the hemostasis valve 70 different from the hemostasis valve 13 described above will be described in detail, and description of the configuration of the other blood collection tube 10 will be omitted.

(Hemostatic valve 70)
As shown in FIG. 13, the hemostasis valve 70 is a duckbill type that protrudes along the axial direction 101 of the tube body 11, and has a slit 71 that can be elastically deformed at the protruding end of the duckbill type. The hemostasis valve 70 is made of an elastic member through which the blood collection needle 14 can be pierced. Although not shown in the drawing, the hemostasis valve 70 is disposed in the internal space of the tube body 11 in the same manner as the hemostasis valve 13 described above with its duckbill-type protruding end toward the bottom side of the tube body 11. Be placed.

  The hemostatic valve 70 maintains a state where the slit 71 is closed in a state where no external force is applied. Therefore, the blood 102 does not flow through the slit 71. That is, the hemostasis valve 60 is closed. As shown in FIG. 14, the hemostasis valve 70 guides the pipette nozzle 16 and the blood collection needle 14 inserted from the open end 20 side of the tube body 11 to the slit 71 by the duckbill type. When the nozzle 16 or the like is inserted into the slit 71, the slit 71 is elastically deformed and opened. Thereby, the hemostatic valve 70 will be in an open state. Such a hemostasis valve 70 also provides the same effect as that of the above-described embodiment.

FIG. 1 is a perspective view showing an external configuration of a blood collection tube 10 according to the first embodiment of the present invention. FIG. 2 is an exploded perspective view of the blood collection tube 10. FIG. 3 is a longitudinal sectional view of the blood collection tube 10. FIG. 4 is a longitudinal sectional view showing a state in which blood is collected by the blood collection tube 10. FIG. 5 is a longitudinal sectional view showing a state after blood collection by the blood collection tube 10. FIG. 6 is a longitudinal sectional view showing a state where the blood collection tube 10 after blood collection is manually opened. FIG. 7 is a longitudinal sectional view showing a state in which blood 102 is dispensed from the blood collection tube 10 after opening. FIG. 8 is a longitudinal cross-sectional view showing a state in which a hole is made in the sheet 12 by the nozzle 16 and blood 102 is dispensed from the blood collection tube 10. FIG. 9A is an exploded perspective view showing the hemostatic valve 40 according to the first modification, and FIG. 9B is a plan view showing the hemostatic valve 40. FIG. 10A is a plan view showing a hemostasis valve 50 according to a second modification, and FIG. 10B is a cross-sectional view showing the hemostasis valve 50 along the IX-IX cutting line. FIG. 11A is a plan view showing a hemostasis valve 60 according to a third modification, and FIG. 11B is a cross-sectional view showing the hemostasis valve 60 along the XX cutting line. FIG. 12 is a cross-sectional view showing a state where the hemostasis valve 60 is opened by the nozzle 16. FIG. 13A is a plan view showing a hemostasis valve 70 according to a fourth modification, and FIG. 13B is a cross-sectional view showing the hemostasis valve 70 along the XII-XII cutting line. FIG. 14 is a cross-sectional view showing a state where the hemostasis valve 70 is opened by the nozzle 16.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Blood collection tube 11 ... Tube main body 12 ... Sheet | seat 13,40,50,60,70 Hemostatic valve 20 ... Open end (1st end)
22 ... 1st chamber 23 ... 2nd chamber 31, 71 ... Slit 43 ... Slit (1st slit)
44 ... Slit (second slit)
61 ... hole 102 ... blood 101 ... axial direction (longitudinal direction)

Claims (5)

A tube body having an open first end and capable of storing blood in the internal space;
A sheet bonded to the first end of the tube body to close the opening;
The hemostasis is fixed at a certain position on the first end side in the tube body, and divides the first chamber on the first end side and the second chamber on the opposite side with respect to the longitudinal direction of the tube body. A valve,
The internal space of the tube body is held airtight by the sheet and is in a reduced pressure state with respect to atmospheric pressure,
The second chamber stores the collected blood,
The hemostasis valve is a blood collection tube which does not move in the longitudinal direction of the tube main body by centrifugation, and a hole previously drilled in the longitudinal direction of the tube main body opens by elastic deformation.   2. The blood collection tube according to claim 1, wherein the hemostasis valve is a membrane having a thin thickness along the longitudinal direction of the tube body, and has a slit penetrating the membrane in the longitudinal direction of the tube body as the hole. .   The blood collection tube according to claim 1, wherein the hemostasis valve has a funnel shape protruding along a longitudinal direction of the tube main body, and has the hole that can be expanded in diameter at the tip of the funnel shape.   The blood collection tube according to claim 1, wherein the hemostasis valve is of a duckbill type.   5. The hemostasis valve according to any one of claims 1 to 4, wherein the hemostasis valve is capable of being pierced with a needle and capable of liquid-tightly closing a puncture passage formed by the needle after the needle is removed. The blood collection tube described.

Images