JP5470393B2 - ドライパウダー吸入器 - Google Patents
ドライパウダー吸入器 Download PDFInfo
- Publication number
- JP5470393B2 JP5470393B2 JP2011529237A JP2011529237A JP5470393B2 JP 5470393 B2 JP5470393 B2 JP 5470393B2 JP 2011529237 A JP2011529237 A JP 2011529237A JP 2011529237 A JP2011529237 A JP 2011529237A JP 5470393 B2 JP5470393 B2 JP 5470393B2
- Authority
- JP
- Japan
- Prior art keywords
- dose
- piercing
- disk
- dose container
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Description
本出願は、2009年4月20日に出願された米国仮特許出願第61/170,801号、2008年9月26日に出願された米国仮特許出願第61/100,482号、および2009年1月30日に出願された米国仮特許出願第61/148,520号の利得および優先権を主張するものであり、その開示内容は、参照することによって、あたかもそれらの全体が記載されているかのように、ここに含まれるものとする。
本発明は、吸入器に関し、特にドライパウダー吸入器に適するものである。
Claims (8)
- 異なる半径の第1および第2の同心列に配置されている周方向に互いに離間した複数のドライパウダードーズ容器を有するドーズ容器ディスクと、
順次、前記第1の列におけるドライパウダードーズ容器を開封し、前記第2の列におけるドライパウダードーズ容器を開封するように構成された突刺機構であって、半径方向において互いに隣接して離間した関係にある第1および第2の細長突刺部材であって、各突刺部材は、突刺位置と非突刺位置との間で往復運動を行うことが可能になっており、各突刺部材は、遠位側突刺部および近位側ヘッド部を備えており、前記第1の突刺部材は、前記第1の列におけるドーズ容器のシーリング材を突き刺すように構成されており、前記第2の突刺部材は、前記第2の列におけるドーズ容器のシーリング材を突き刺すように構成されている、第1および第2の細長突刺部材を備えている、突刺機構と、
を備えていることを特徴とするドライパウダー吸入器。 - ハウジングであって、前記ドーズ容器ディスクが前記ハウジング内に回転可能に取り付けられており、前記ドーズ容器ディスクは、互いに向き合った上下主面と、第1の半径において周方向に互いに離間したドーズ容器の第1の列および第2の半径において周方向に互いに離間したドーズ容器の第2の列を有しており、前記第1の列および前記第2の列は、前記ディスクの中心に対して同心になっており、前記ドーズ容器は、ドライパウダーを含んでいる、ハウジングと、
前記ドーズ容器ディスクの前記上下主面の少なくとも1つを覆って配置されている柔軟シーリング材と、
をさらに備えており、
前記突刺機構は、前記第1の列におけるドーズ容器の前記シーリング材を突き刺し、前記第2の列におけるドーズ容器の前記シーリング材を突き刺すように構成されていることを特徴とする、請求項1に記載のドライパウダー吸入器。 - 前記突刺機構は、各突刺部材を後退位置に付勢するように構成された付勢部材を備えていることを特徴とする、請求項1に記載のドライパウダー吸入器。
- 第1の位置と第2の位置との間で移動可能になっているアクチュエータをさらに備えており、前記第1の位置から前記第2の位置への前記アクチュエータの移動によって、前記ドーズ容器ディスクが、前記吸入器の出口気流経路の界面または壁に密封係合するようになっていることを特徴とする、請求項1に記載のドライパウダー吸入器。
- 前記アクチュエータは、付勢ポストを備えており、前記第1の位置から前記第2の位置への前記アクチュエータの移動によって、前記付勢ポストが、前記ドーズ容器ディスクを、前記吸入器の出口気流経路の界面または壁に密封係合すべく、付勢するようになっていることを特徴とする、請求項4に記載のドライパウダー吸入器。
- 前記第1の列のドーズ容器は、前記第2の列のドーズ容器の中心線から周方向に離間した中心線を有し、30個のドーズ容器が前記第1の列に配置されており、30個のドーズ容器が前記第2の列に配置されていることを特徴とする、請求項1に記載のドライパウダー吸入器。
- 各突刺部材は、前記シーリング材を突き刺すように構成された溝付き突刺具を含んでいることを特徴とする、請求項2に記載のドライパウダー吸入器。
- 各ドーズ容器は、気管支拡張剤、吸入コルチコステロイド薬(ICS)、および抗コリン薬からなる群から選択される薬学的活性剤を有するドライパウダーを含んでおり、
前記気管支拡張剤は、
アルブテロール、サルメテロール、エフェドリン、アドレナリン、フェノテロール、フォルモテロール、イソプレナリン、メタプロテレノール、フェニレフリン、フェニルプロパノールアミン、ピルブテロール、レプロテロール、リミテロール、テルブタリン、イソエタリン、ツロブテロール、または(−)−4−アミノ−3,5−ジクロロ−α−[[6−[2−(2−ピリニジニル)エトキシ]ヘキシル]メチル]ベンゼンメタノールからなる群から選択され、
前記気管支拡張剤は、
塩、エステル、または溶媒和物の形態で用いて、これによって、
前記薬剤の活性および/または安定性が最適化するようになっており、
前記吸入コルチコステロイド薬は、
ジプロピオン酸ベクロメタゾン、プロピオン酸フルチカゾン、フルニソリド、ブデソニド、フロ酸モメタゾン、およびトリアムシノロンアセトニドからなる群から選択され、
前記抗コリン薬は、イプラトロピウム、チオトロピウム、アトロピン、およびオキシトロピウムからなる群から選択されることを特徴とする、請求項1に記載のドライパウダー吸入器。
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PCT/US2009/058281 WO2010036836A1 (en) | 2008-09-26 | 2009-09-25 | Dry powder inhalers with dual piercing members and related devices and methods |
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CA2732840A1 (en) | 2010-04-01 |
EP2346556A1 (en) | 2011-07-27 |
US8381721B2 (en) | 2013-02-26 |
US20130133653A1 (en) | 2013-05-30 |
CN102159269A (zh) | 2011-08-17 |
US20150157812A1 (en) | 2015-06-11 |
KR20110063560A (ko) | 2011-06-10 |
SI2346556T1 (sl) | 2015-02-27 |
MX2011003233A (es) | 2011-04-28 |
BRPI0919126A2 (pt) | 2015-12-08 |
CA2732840C (en) | 2016-07-05 |
WO2010036836A1 (en) | 2010-04-01 |
JP2014138861A (ja) | 2014-07-31 |
AU2009296535B2 (en) | 2013-04-18 |
KR101650075B1 (ko) | 2016-08-22 |
CN102159269B (zh) | 2014-05-07 |
BRPI0919126B1 (pt) | 2021-07-27 |
AU2009296535A1 (en) | 2010-04-01 |
US9795749B2 (en) | 2017-10-24 |
US20100078021A1 (en) | 2010-04-01 |
EP2346556B1 (en) | 2014-11-05 |
ES2528657T3 (es) | 2015-02-11 |
JP5809301B2 (ja) | 2015-11-10 |
US8985103B2 (en) | 2015-03-24 |
JP2012503530A (ja) | 2012-02-09 |
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