JP5206889B2 - Nasopharyngeal irrigation solution - Google Patents

Description

Detailed Description of the Invention

  The present invention adsorbs germs, dust, pollen, etc. in the nasal cavity and throat and almost completely flushes it out, reduces irritation to the mucous membrane during washing, has immediate effect on healing of mucosal inflammation, and has a long-term effect. The present invention relates to a nasal and throat cleaning solution that keeps the mucous membrane healthy.

For example, Patent Document 1 states that “a cleaning agent containing deep water or a combination of deep water and an active ingredient. The active ingredients to be added are cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, popidone iodine, chloride. Decalinium, chlorhexidine gluconate, dipotassium glycyrrhizinate, naphazoline hydrochloride, chlorpheniramine maleate, lidocaine hydrochloride, zinc sulfate, menthol, camphor, peppermint oil, eucalyptus oil, fennel oil, cinnamon oil, clove oil, etc. “Cleaning agents packaged in single doses or aerosol type” are provided.

  Further, it is described that “a cleaning agent that can easily clean the oral cavity or nasal cavity and has an excellent feeling of use” is provided.

  However, this cleansing agent does not contain an appropriate amount of salt, and it still cannot sufficiently wash away germs and dust in the nasal cavity and throat. In addition, irritation to the mucous membrane during washing cannot be sufficiently alleviated. Furthermore, it has an immediate effect on the healing of inflammation of the mucosa and does not keep the mucosa healthy for a long time.

  Patent Document 2 provides “a nasal cleansing agent characterized by blending deep ocean water”.

  And, it provides a deep-sea water combination nasal cleanser that is hypoallergenic and highly effective for allergic rhinitis.

  In addition, "... When seawater itself is used, the inorganic ions such as sodium chloride contained in excess cause strong irritation and pain in washing. Therefore, the deep water source water of the present invention is diluted, Ion exchange treatment, reverse osmosis membrane treatment, multi-stage electrodialysis water diluted or ion exchange membrane treatment, reverse osmosis membrane treatment, multi-stage electrodialysis desalination, ion exchange membrane treatment, Hypoallergenic nasal irrigation by adjusting the osmotic pressure by adjusting the concentration of inorganic ions such as sodium chloride by adding ionic components to the water obtained by desalting by reverse osmosis membrane treatment and multistage electrodialysis treatment Provide the agent "(paragraph 0007).

  However, in this deep-sea water nasal cleansing agent, water that has been subjected to ion exchange treatment, reverse osmosis membrane treatment, and multistage electrodialysis treatment is diluted, or ion exchange membrane treatment, reverse osmosis membrane treatment, multistage electrodialysis A complex process is required to obtain a hypoallergenic nasal cleanser such as desalting by treatment, and conversely, sodium and chloride ion concentrations are low due to low salt content, so that bacteria in the nasal cavity and throat, Dust and the like cannot be washed away sufficiently, have an immediate effect on healing of inflammation of the mucous membrane, and are not intended to keep the mucosa healthy for a long time.

  JP 2001-247446 A   JP 2002-212081 A

Problems to be solved by the invention

The present invention adsorbs bacteria, dust, pollen, etc. in the nasal cavity and throat by using an intranasal throat cleaning solution with sodium of 1500-13000 mg / L, chloride ions of 2550-21000 mg / L, and pH 8.0 or higher. Accordingly, it is intended to provide a nasopharyngeal irrigation solution that eliminates irritation to the mucous membrane during washing, has an immediate effect on healing of inflammation of the mucous membrane, and keeps the mucosa healthy for a long period of time.

Means to solve the problem

The invention of claim 1 is based on water having an average particle size of 0.01-1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more of 0.6-5 wt. A nasal and throat irrigation solution having a sodium content of 1500 to 13000 mg / L, a chloride ion of 2550 to 21000 mg / L, and a pH of 8.0 or higher .

In the present invention, by adding an appropriate amount of ultrafine bamboo charcoal salt having an average particle diameter of 0.01 to 1 μm, sodium and chloride ions have an appropriate concentration, and in particular, the concentration of chloride ions is sodium. Higher, bamboo charcoal salt permeates the mucous membrane in the nasal cavity without irritating and adsorbs dust and germs adhering to the mucous membrane to wash away most of them, so that the refreshing feeling after washing becomes very good. Further, since the use of water and Takesumishio high alkalinity low oxidation potential to suppress oxidation of the mucous membranes of the nasal cavity, synergistic effects are obtained that healing effect is high and can impart immediate with relieve inflammation of the mucosa.

Sodium is less than 1500 of the nasal腔咽throat within in the washing liquid, the effect of washing away adsorbed dust and bacteria that chloride ions are attached to the mucosa is less than 2550 is thin. Moreover, when sodium exceeds 13000 mg / L and chloride ion exceeds 21000 mg / L, the irritation | stimulation to a mucous membrane in a nasal cavity is too strong and the refreshing feeling after washing | cleaning will become very bad. Preferably, sodium is 5200 to 10500 mg / L and chloride ion is 8400 to 16800 mg / L.

  Furthermore, if the pH is less than 8.0, the oxidation of the mucous membrane in the nasal cavity cannot be suppressed, the healing effect of the mucosal inflammation cannot be obtained, and the immediate effect of the healing effect cannot be obtained. Preferably, the pH is 9.0 or more.

The water preferably has a pH of 7.0 or more and a redox potential of 250 mv or less, more preferably a pH of 8.0 or more and a redox potential of 200 mv or less. If the pH of the water is 6.0 or less and the oxidation-reduction potential is 300 mV or more, the oxidation of the mucous membrane in the nasal cavity cannot be suppressed, and the effect of healing the inflammation of the mucous membrane cannot be obtained. Can not be obtained.

The invention according to claim 2 provides the nasal and throat washing liquid according to any one of claims 1 to 2, wherein the water has a water-soluble germanium of 5.0 ppb / l or more and a pH of 8.0 or more.

In this invention, by using natural alkaline ionized water containing a large amount of water-soluble germanium, which is a nutritional component contained in ginseng, ganoderma, sarcoma, garlic, etc., this is also a very small water-soluble cluster. In order to prevent the recurrence of hay fever, the nutrient is infiltrated into the bloodstream such as the mucous membrane in the nasal cavity to ensure the mucosa healthy over a long period of time. Therefore, the synergistic effect of the alkaline water with low oxidation potential and high alkaline water and bamboo charcoal salt with ultrafine particles with low oxidation-reduction potential suppresses the oxidation of the mucous membrane in the nasal cavity and relieves inflammation of the mucosa, and is extremely effective immediately A healing effect is obtained.

  The water is preferably water-soluble germanium 7.0 ppb / l or more, more preferably 8.0 ppb / l or more.

Trial test

The water and salt used in the following trial tests are shown below.
Water: A = Natural alkaline ionized water that springs from 800m underground in Tarumi City, Kagoshima Pref. 100 times or more), hydrogen ion concentration (pH) 9.4
B = Normally available mineral water = pH 6.5 , redox potential 250 mv
C = deep ocean water (from Kashiwajima, Kagoshima) = pH 7.0 , redox potential 250 mV)
D = tap water (sodium about 200 mg / L, chloride ion about 200 mg / L)
Salt: X = bamboo charcoal salt (Japanese Patent Laid-Open No. 2010-273661) = average particle size 0.01-1 μm, oxidation-reduction potential 0 mV or less, pH 8.0 or more Y = commercial bamboo salt (Korean product) = average particle size unknown, oxidation Reduction potential unknown, pH unknown Z = salt = unknown

Trial test 1

  As shown in Table 1, trial test 1 was carried out by applying nasopharyngeal lavage fluid in which 3.5 wt% of each salt was added to each of the above waters (7 g of salt to 200 cc of water) to each 10 hay fever patients. This was used as a spray washing, and the results of irritation in the nasal cavity, refreshment after washing, and improvement of hay fever were summarized. As a result, most of the 10 people answered that they did not feel any irritation in the nasal cavity. ◎, those who answered a little irritation but no discomfort ○, those who answered i felt a little irritation, An X was given to those who replied that there was a fairly severe stimulus.

  Similarly, as for the refreshment after washing, ◎ for those who answered that most of 10 people had a refreshing feeling after washing, ○ for those that felt a little refreshing feeling, A mark was given to those who answered that there was almost no change, and a mark to those that felt uncomfortable.

  Furthermore, regarding the improvement of hay fever, as for the exhilaration after washing, most of the 10 respondents answered that they were completely cured after one week of washing, ◎, and those who answered that they became much easier, ○ △ is added to those who answered that there is a mark, and × was added to those who answered that there was no improvement.

As can be seen from Table 1, Sample 1 contains 8.89 ppb of water-soluble germanium, pH 9. No. 4 of natural alkaline ionized water (A) that springs from 800 m underground in Tarumi City, Kagoshima Prefecture, 3.5 wt. Of bamboo charcoal salt (X) with an average particle size of 0.01 to 1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more In addition, irritation in the nasal cavity, refreshment after washing, and improvement of hay fever were all the best.

In addition, a bamboo charcoal salt (X) having an average particle size of 0.01 to 1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more with respect to a commercially available mineral water (B) and a deep sea water (C) of pH 6.5. Samples 4 and 7 to which 3.5 wt% was added also showed good nasal irritation, refreshment after washing, and improvement of hay fever.

  On the other hand, Samples 2, 3, 5, 6, 8, 9, 11, and 12 to which bamboo charcoal salt (X) is not added are not sufficient for improving irritation in the nasal cavity, refreshing after washing, and hay fever. There wasn't. Also, good results were not obtained for Samples 3, 6, 9, 12 using salt (Z) and Samples 10, 11, 12 using tap water (D).

  From the above results, by adding ultra-fine bamboo charcoal salt with an average particle size of 0.01 to 1 μm, the bamboo charcoal salt penetrates the mucous membrane of the nasal mucosa without any irritation and adheres to the mucous dust and bacteria. It is considered that the refreshing feeling after washing is extremely good because it is adsorbed and almost washed away. In addition, since water having a low oxidation potential and high alkalinity and bamboo charcoal salt are used, a synergistic effect is obtained in which the oxidation of the mucous membrane in the nasal cavity is suppressed, the inflammation of the mucous membrane is relieved, the healing effect is high, and the immediate effect is imparted.

  In addition, by using natural alkaline ionized water containing a large amount of water-soluble germanium, which is a nutrient component contained in ginseng, ganoderma, sarcoma, garlic, etc. In order to prevent the recurrence of hay fever, the nutrient is infiltrated into the bloodstream of the skin to ensure the mucosa is healthy over a long period of time.

Trial test 2

In trial test 2, as shown in Table 2, the nasopharyngeal lavage fluid in which 3.5 wt% of each salt was added to each of the above waters (7 g of salt for 200 cc of water) was separately used for 10 allergic rhinitis cases. This was used as a nasal spray wash for patients, and the results of improvement in nasal irritation, refreshment after washing, and allergic rhinitis were summarized. As a result, most of the 10 people answered that they did not feel any irritation in the nasal cavity. ◎, those who answered a little irritation but no discomfort ○, those who answered i felt a little irritation, An X was given to those who replied that there was a fairly severe stimulus.

  Similarly, as for the refreshability after washing, ◎ for those who answered that almost 10 out of 10 each had a very refreshing feeling after washing, ○ for those that felt a little refreshing feeling, before washing △ was added to those who answered that they were almost the same, and X was added to those that felt uncomfortable.

  Furthermore, with regard to the improvement of allergic rhinitis, ◎ responded that most of the 10 responded that it was completely cured after 1 week of washing, ○ responded that it became much easier, and responded that there were still some symptoms A mark was attached to a thing that answered that there was no improvement at all.

As can be seen from Table 2, sample 2-1 contains 8.89 ppb of water-soluble germanium, and has an average particle size of 0 for natural alkaline ionized water (A) springing from 800 m underground in Tarumi City, Kagoshima Prefecture, pH 9.4. 0.01 ~ 1μm, redox potential 0mv or less, pH 8.0 or more added bamboo charcoal salt (X) 3.5wt%, irritability in the nasal cavity, refreshment after washing, allergic rhinitis improvement status Everything was the best.

In addition, a bamboo charcoal salt (X) having an average particle size of 0.01 to 1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more with respect to a commercially available mineral water (B) and a deep sea water (C) of pH 6.5. Samples 2-4 and 2-7 to which 3.5 wt% was added also showed good nasal irritation, refreshment after washing, and improvement of allergic rhinitis.

  On the other hand, samples 2-2, 2-3, 2-5, 2-6, 2-8, 2-9, 2-11, and 2-12 to which no bamboo charcoal salt (X) was added were stimulated in the nasal cavity. , Refreshment after washing, and improvement of allergic rhinitis were not sufficient. Further, samples 2-3, 2-6, 2-9, 2-12 using salt (Z) and samples 2-10, 2-11, 2-12 using tap water (D) are also good. No result was obtained.

  From the above results, as in the trial test 1, the addition of ultrafine bamboo charcoal salt having an average particle size of 0.01 to 1 μm allows the bamboo charcoal salt to penetrate smoothly into the mucous membrane of the nasal mucosa without irritation. It is thought that the refreshing feeling after washing becomes extremely good because most of the dust and germs adhering to the surface are adsorbed and washed away. In addition, the use of alkaline water and bamboo charcoal salt with low oxidation potential suppresses the oxidation of the mucous membrane in the nasal cavity, relieves mucosal inflammation, and provides a synergistic effect that has a high healing effect and immediate effect on allergic rhinitis. It is done.

  Furthermore, by using natural alkaline ionized water containing a large amount of water-soluble germanium, it is a very small water-soluble cluster, so that nutrients can penetrate into the bloodstream of the intranasal mucosa, etc. to ensure a healthy mucosa over a long period of time. Therefore, recurrence of allergic rhinitis can be prevented.

Trial test 3

  In trial test 3, as shown in Table 3, each urinary and throat washing solution in which 3.5 wt% of each salt is added to each of the above waters (7 g of salt is added to 200 cc of water) is separately applied to 10 abscess patients. Inhalation into the nasal cavity and exhalation from the mouth were used for trial purposes, and the results of improvement in the irritation in the nasal cavity, refreshment after washing, and empyema were summarized. As a result, most of the 10 people answered that they did not feel any irritation in the nasal cavity. ◎, those who answered a little irritation but no discomfort ○, those who answered i felt a little irritation, An X was given to those who replied that there was a fairly severe stimulus.

  Similarly, as for the refreshment after washing, ◎ for those who answered that most of 10 people had a refreshing feeling after washing, ○ for those that felt a little refreshing feeling, A mark was given to those who answered that there was almost no change, and a mark to those that felt uncomfortable.

  Furthermore, with regard to the improvement status of empyema, most of the 10 respondents answered that they were completely cured after 3 months of washing, ○ responded that they had become much easier, ○ responded that they still had some symptoms △, X which attached that there was no improvement at all.

As can be seen from Table 3, Sample 3-1 contains 8.89 ppb of water-soluble germanium, and has an average particle size of 0 for natural alkaline ionized water (A) springing from 800 m underground in Tarumi City, Kagoshima Prefecture, pH 9.4. 0.01 ~ 1μm, redox potential 0mv or less, pH 8.0 or more added bamboo charcoal salt (X) 3.5wt%, all the irritation in the nasal cavity, refreshment after washing, improvement status of empyema It was the best.

In addition, a bamboo charcoal salt (X) having an average particle size of 0.01 to 1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more with respect to a commercially available mineral water (B) and a deep sea water (C) of pH 6.5. Samples 3-4 and 3-7 added with 3.5 wt% also showed good nasal irritation, refreshment after washing, and improvement of empyema.

  On the other hand, samples 3-2, 3-3, 3-5, 3-6, 3-8, 3-9, 3-11 and 3-12 to which bamboo charcoal salt (X) is not added are stimuli in the nasal cavity. The improvement of sexuality, exhilaration after washing, and empyema was not sufficient. Good results were also obtained for samples 3-3, 3-6, 3-9 using salt (Z) and samples 3-10, 3-11, 3-12 using tap water (D). There wasn't.

  From the above results, as in the above trial tests 1 and 2, by adding ultrafine bamboo charcoal salt with an average particle size of 0.01 to 1 μm, bamboo charcoal salt penetrates smoothly into the nasal mucosa details without irritation. It is thought that the refreshing feeling after washing is extremely good because most of the dust and bacteria adhering to the mucous membrane are adsorbed and washed away. In addition, since alkaline water and bamboo charcoal salt having a low oxidation potential are used, the mucosal oxidation in the nasal cavity is suppressed, the mucosal inflammation is relieved, and a synergistic effect is obtained that has a high healing effect for empyema and imparts immediate effect.

  Furthermore, by using natural alkaline ionized water that contains a large amount of water-soluble germanium, this is an extremely small water-soluble cluster, so that nutrients can penetrate into the bloodstream of the intranasal mucosa, etc. to ensure the health of the mucosa for a long time. Therefore, recurrence of empyema can be prevented.

Trial test example 4
In trial test 4, as shown in Table 4, nasal and throat irrigation solution in which bamboo charcoal salt was added in the range of 0.4 to 7 wt% to each of the above waters was separately applied to 10 hay fever patients as nasal spray washing. Trial was used to summarize the results of irritability in the nasal cavity, refreshment after washing, and improvement of hay fever. As a result, most of the 10 people answered that they did not feel any irritation in the nasal cavity. ◎, those who answered a little irritation but no discomfort ○, those who answered i felt a little irritation, An X was given to those who replied that there was a fairly severe stimulus.

  Similarly, as for the refreshment after washing, ◎ for those who answered that most of 10 people had a refreshing feeling after washing, ○ for those that felt a little refreshing feeling, A mark was given to those who answered that there was almost no change, and a mark to those that felt uncomfortable.

  Furthermore, regarding the improvement of hay fever, as for the exhilaration after washing, most of the 10 respondents answered that they were completely cured after one week of washing, ◎, and those who answered that they became much easier, ○ △ is added to those who answered that there is a mark, and × was added to those who answered that there was no improvement.

  As understood from Table 4, the amount of salt added to tap water is usually 0.9 to 2.0 wt% for nasal irrigation, but the bamboo charcoal salt of the present invention is 0.6 to 6%. It can be added in the range of 5 wt%. That is, it is understood that even when the content is 0.9 wt% or less, the above characteristics are obtained, and when the content exceeds 2.0 wt%, irritation in the nasal cavity is hardly felt. Therefore, it is understood that bamboo charcoal salt can be added in the range of 0.6 to 5 wt% in the present invention.

  Although the above experimental example was used as a nasal wash for nasal irrigation of patients with hay fever, allergic rhinitis, empyema, etc., it can also be used for throat gargles, other athlete's foot and other inflammatory sites. In nasal irrigation, the irrigation of the nasal mucosa can be further alleviated in combination with the mildness of bamboo charcoal salt by spraying the cleaning liquid of the present invention in a fine mist.

For samples 1, 2-1, 3-1 (A + X) and (taken with 3.5% by weight of bamboo charcoal salt) used in trial tests 1, 2, and 3, the concentrations of sodium and chloride ions were determined by ion chromatography. As a result, the sodium was 9160 mg / L and the chloride ion was 14700 mg / L. Since these samples have an added amount of bamboo charcoal salt (X) of 3.5 wt%, sodium and chloride ion at an added amount of 0.6 to 5 wt% according to claim 2 of the present invention are approximately 1500. ˜13000 mg / L and chloride ions are in the range of 2550 to 21000 mg / L. The pH was 10.2.

  Furthermore, for samples 1, 2-1, 3-1 (A + X) used for trial tests 1, 2, and 3, the SS (suspended material) was measured by JIS K 0I0I (according to the industrial water test method), It was 143 mg / L. This SS (suspension material) is mainly composed of extremely fine carbon particles (0.001 to 1 μm) generated in the steamed state of the salt in the bamboo cylinder when the bamboo charcoal salt (X) is produced. Therefore, by adding ultra-fine bamboo charcoal salt, the bamboo charcoal salt penetrates gently into the mucous membrane of the nasal cavity without irritation and adsorbs dust and bacteria adhering to the mucous membrane, washing away most of it. It is considered that the feeling is extremely good. In addition, since alkaline water and bamboo charcoal salt with low oxidation potential are used, the synergistic effect of suppressing inflammation of the mucous membrane in the nasal cavity and reducing inflammation of the mucosa and giving a high healing effect and immediate effect is promoted. Conceivable.

  Since the amount of bamboo charcoal salt (X) added to the above sample is 3.5 wt%, the concentration of SS (suspended substance) at an addition amount of 0.6 to 5 wt% according to claim 2 of the present invention is approximately calculated. It becomes the range of 24-204 mg / L. Preferably it is the range of 81-164 mg / L.

Effect of the invention

The present invention contains 0.6-5% bamboo charcoal salt having an average particle size of 0.01-1 μm, a redox potential of 0 mV or less, and a pH of 8.0 or more with respect to water having a pH of 6.0 or more and a redox potential of 300 mV or less. as hereinbefore, since sodium 1500~13000mg / L, chloride ion was 2550~21000mg / L, nasal腔咽throat in the washing liquid is pH8.0 or higher, by the addition of bamboo charcoal salt ultrafine, Takesumishio However, since the dust and germs adhering to the mucous membrane smoothly penetrate into the nasal mucosa without irritating and adhering to the mucous membrane, most of it is washed away, so that the refreshing feeling after washing becomes very good. Furthermore, synergistic effects are obtained that healing effect is high and imparting immediate with suppressing oxidation of the mucous membrane in the nasal cavity relieve inflammation of the mucous membrane because it uses water and Takesumishio high low oxidation potential alkalinity.

Further, the water has a water-soluble germanium of 5.0 ppb / l or more, a hydrogen ion concentration (pH) of 8.0 or more, and a large amount of water-soluble germanium, which is a nutritional component contained in ginseng, ganoderma, sarcocarp, garlic, etc. the use of natural alkaline ion water containing, this is infiltrated nutrients into the bloodstream, such as nasal mucosa soundly secured over the mucosa long since it is also a very small water clusters. Therefore, recurrence of hay fever, allergic rhinitis, empyema, etc. can be prevented. In addition, the use of alkaline water and bamboo charcoal salt, which has a low oxidation potential as described above, suppresses oxidation of the mucous membrane in the nasal cavity and relieves inflammation of the mucous membrane, while increasing the healing effect and immediate effect on healing of the mucosal inflammation. It has a synergistic effect that keeps the mucous membrane healthy for a long time.

Claims (2)

A bamboo charcoal salt having an average particle size of 0.01 to 1 μm, an oxidation-reduction potential of 0 mV or less, and a pH of 8.0 or more is contained in water having a pH of 6.0 or more and an oxidation-reduction potential of 300 mV or less, and sodium is 1500%. An intranasal throat washing solution having ˜13000 mg / L, chloride ion of 2550 to 21000 mg / L, and pH 8.0 or higher. The nasal throat irrigation liquid according to claim 1, wherein the water is water-soluble germanium 5.0 ppb / l or more and pH 8.0 or more.