JP4825455B2 - 粉末吸入器 - Google Patents
粉末吸入器 Download PDFInfo
- Publication number
- JP4825455B2 JP4825455B2 JP2005161930A JP2005161930A JP4825455B2 JP 4825455 B2 JP4825455 B2 JP 4825455B2 JP 2005161930 A JP2005161930 A JP 2005161930A JP 2005161930 A JP2005161930 A JP 2005161930A JP 4825455 B2 JP4825455 B2 JP 4825455B2
- Authority
- JP
- Japan
- Prior art keywords
- actuating member
- mouthpiece
- dual function
- amino
- inhaler
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 239000000843 powder Substances 0.000 title description 2
- 230000009977 dual effect Effects 0.000 claims description 38
- 239000002775 capsule Substances 0.000 claims description 37
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- -1 cyclopropyl tropine benzylate Chemical compound 0.000 description 45
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 27
- FIMXSEMBHGTNKT-UHFFFAOYSA-N Scopine Natural products CN1C2CC(O)CC1C1C2O1 FIMXSEMBHGTNKT-UHFFFAOYSA-N 0.000 description 11
- FIMXSEMBHGTNKT-RZVDLVGDSA-N scopine Chemical compound C([C@@H]1N2C)[C@H](O)C[C@@H]2[C@@H]2[C@H]1O2 FIMXSEMBHGTNKT-RZVDLVGDSA-N 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 239000012453 solvate Substances 0.000 description 6
- 150000004677 hydrates Chemical class 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- ODELFXJUOVNEFZ-UHFFFAOYSA-N 2,2-diphenylpropanoic acid Chemical compound C=1C=CC=CC=1C(C(O)=O)(C)C1=CC=CC=C1 ODELFXJUOVNEFZ-UHFFFAOYSA-N 0.000 description 3
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- 239000013543 active substance Substances 0.000 description 3
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 description 3
- MAGCRYYXZYUDSY-UHFFFAOYSA-N 2-fluoro-2,2-diphenylacetic acid Chemical compound C=1C=CC=CC=1C(F)(C(=O)O)C1=CC=CC=C1 MAGCRYYXZYUDSY-UHFFFAOYSA-N 0.000 description 2
- ULMFXAMQUGLVGA-LJQANCHMSA-N 3-[[2-methoxy-4-[(2-methylphenyl)sulfonylcarbamoyl]phenyl]methyl]-1-methyl-n-[(2r)-4,4,4-trifluoro-2-methylbutyl]indole-5-carboxamide Chemical compound C=1C=C(CC=2C3=CC(=CC=C3N(C)C=2)C(=O)NC[C@H](C)CC(F)(F)F)C(OC)=CC=1C(=O)NS(=O)(=O)C1=CC=CC=C1C ULMFXAMQUGLVGA-LJQANCHMSA-N 0.000 description 2
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- PUPWRKQSVGUBQS-UHFFFAOYSA-N 9-methylfluorene-9-carboxylic acid Chemical compound C1=CC=C2C(C)(C(O)=O)C3=CC=CC=C3C2=C1 PUPWRKQSVGUBQS-UHFFFAOYSA-N 0.000 description 2
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- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- 229940121948 Muscarinic receptor antagonist Drugs 0.000 description 2
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- 230000000712 assembly Effects 0.000 description 2
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- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 239000000812 cholinergic antagonist Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
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- 238000000034 method Methods 0.000 description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
- DPHDSIQHVGSITN-UHFFFAOYSA-N n-(3,5-dichloropyridin-4-yl)-2-[1-[(4-fluorophenyl)methyl]-5-hydroxyindol-3-yl]-2-oxoacetamide Chemical compound C1=C(C(=O)C(=O)NC=2C(=CN=CC=2Cl)Cl)C2=CC(O)=CC=C2N1CC1=CC=C(F)C=C1 DPHDSIQHVGSITN-UHFFFAOYSA-N 0.000 description 2
- 229960002657 orciprenaline Drugs 0.000 description 2
- 150000003431 steroids Chemical class 0.000 description 2
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 2
- CYHOMWAPJJPNMW-JIGDXULJSA-N tropine Chemical compound C1[C@@H](O)C[C@H]2CC[C@@H]1N2C CYHOMWAPJJPNMW-JIGDXULJSA-N 0.000 description 2
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 description 1
- YTKFKKLZSIVJMX-ZDUSSCGKSA-N (6s)-4-[2-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxyethyl]-6-methylmorpholin-2-one Chemical compound C=12C=C(OCCN3CC(=O)O[C@@H](C)C3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 YTKFKKLZSIVJMX-ZDUSSCGKSA-N 0.000 description 1
- NDAUXUAQIAJITI-LBPRGKRZSA-N (R)-salbutamol Chemical compound CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-LBPRGKRZSA-N 0.000 description 1
- VQZNBPALQHPKBM-UHFFFAOYSA-N 1-[4-[4-(3-chloro-2-fluoroanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxypiperidin-1-yl]-2-methoxyethanone Chemical compound ClC=1C(=C(C=CC=1)NC1=NC=NC2=CC(=C(C=C12)OC1CCN(CC1)C(COC)=O)OCCOC)F VQZNBPALQHPKBM-UHFFFAOYSA-N 0.000 description 1
- SDBIIHIBMQQOFY-UHFFFAOYSA-N 1-[4-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-3-methoxypropan-1-one Chemical compound C1CN(C(=O)CCOC)CCC1OC(C(=CC1=NC=N2)OC)=CC1=C2NC1=CC=C(F)C(Cl)=C1 SDBIIHIBMQQOFY-UHFFFAOYSA-N 0.000 description 1
- RCORMCWYMRPHPO-UHFFFAOYSA-N 2,2-bis(3-fluorophenyl)-2-hydroxyacetic acid Chemical compound C=1C=CC(F)=CC=1C(O)(C(=O)O)C1=CC=CC(F)=C1 RCORMCWYMRPHPO-UHFFFAOYSA-N 0.000 description 1
- AOPATQAZIRXNOX-UHFFFAOYSA-N 2-(1-methylcyclopropyl)acetic acid Chemical compound OC(=O)CC1(C)CC1 AOPATQAZIRXNOX-UHFFFAOYSA-N 0.000 description 1
- PSILZZNMGXTOOP-UHFFFAOYSA-N 2-[2-[[2-(4-tert-butyl-1,3-thiazol-2-yl)-1-benzofuran-5-yl]oxymethyl]phenyl]acetic acid Chemical compound CC(C)(C)C1=CSC(C=2OC3=CC=C(OCC=4C(=CC=CC=4)CC(O)=O)C=C3C=2)=N1 PSILZZNMGXTOOP-UHFFFAOYSA-N 0.000 description 1
- KVVDRQDTODKIJD-UHFFFAOYSA-N 2-cyclopropylacetic acid Chemical compound OC(=O)CC1CC1 KVVDRQDTODKIJD-UHFFFAOYSA-N 0.000 description 1
- DBCKRBGYGMVSTI-UHFFFAOYSA-N 2-oxo-7-[2-[2-[3-(2-phenylethoxy)propylsulfonyl]ethylazaniumyl]ethyl]-3h-1,3-benzothiazol-4-olate Chemical compound C1=2SC(=O)NC=2C(O)=CC=C1CCNCCS(=O)(=O)CCCOCCC1=CC=CC=C1 DBCKRBGYGMVSTI-UHFFFAOYSA-N 0.000 description 1
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Images
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Description
4 カプセルホルダー
7 二重機能作動部材
9 プレート
12 マウスピース
13 リッド
14 閉鎖要素
15 上方ライフル面
16 側方ライフル面
Claims (13)
- カプセルから粉末薬剤組成物を吸入する吸入器において、
下側部分(1)と、
前記下側部分(1)にラッチされることができ、且つ、これによって前記下側部分(1)を閉じることができるプレート(9)と、
前記下側部分(1)内に挿入されるように構成されているカプセルを受け入れるためのカプセルホルダー(4)と、
前記プレート(9)にラッチされるマウスピース(12)と、
閉鎖位置において前記マウスピース(12)を覆い、且つ、閉鎖要素(14)によって前記マウスピースをラッチし、単一の連結部により前記下側部分(1)、前記プレート(9)、及び、前記マウスピース(12)と共にヒンジ開閉されるリッド(13)と、
静止位置から移動させることができ、これによって、少なくとも1本のピン(6)と相互に作用して、前記ピンをカプセルホルダー(4)に突き刺すことができる作動部材(7)とを備える吸入器であって、
前記マウスピースは、グリップ補助部を備え、該グリップ補助部により前記マウスピースを側方に向かって反転して開放することができ、前記グリップ補助部はマウスピースの端部に近接し、かつ、前記マウスピースが閉鎖された時に前記作動部材に近接して配置され、
前記作動部材(7)が、第1の作動で前記閉鎖要素(14)を前記下側部分(1)から解放して前記リッド(13)を旋回するようにすることができ、第2の作動でカプセルを突き刺す二重機能作動部材として構成されており、前記作動部材は、前記リッドが閉鎖位置で前記マウスピースをカバーするときに、前記閉鎖要素を受け、かつ、係合する溝を含むことを特徴とする吸入器。 - 前記二重機能作動部材(7)が、プレート(9)、及び、カプセルホルダー(4)のうちの少なくとも一方に移動可能に装着されていることを特徴とする、請求項1に記載の吸入器。
- 前記二重機能作動部材(7)による開放移動を助けるために、バネ要素が前記プレート(9)と前記下側部分(1)との間に配置されていることを特徴とする、請求項1又は2に記載の吸入器。
- 前記二重機能作動部材(7)が前記プレート(9)に移動可能に装着されていることを特徴とする、請求項1又は2に記載の吸入器。
- 前記二重機能作動部材(7)には、バネ荷重が加えられていることを特徴とする、ことを特徴とする請求項1又は2に記載の吸入器。
- 前記二重機能作動部材(7)が、本体と、そこで作動する2つの平行ガイドアーム(18)とからなることを特徴とする、請求項1又は2のいずれかに記載の吸入器。
- 前記二重機能作動部材(7)の本体が、上方ライフル面(15)と、少なくとも1つの側方ライフル面(16)とを含むことを特徴とする、請求項6による吸入器。
- 前記二重機能作動部材(7)が、その上面に傾斜面の形で閉鎖要素(14)の摺動面を形成するために傾斜している凹部(8)を有することを特徴とする、請求項1又は2に記載の吸入器。
- 前記カプセルの突き刺しが、前記二重機能作動部材(7)の作動によって移動されて前記カプセルに穴をあける、1つ又は2以上の側面にそって、オフセットした平行に延びるピン(6)によって行われることを特徴とする、請求項1又は2に記載の吸入器。
- 前記1つのピン、又は、複数のピン(6)が、管状のピンガイドを通して案内されることを特徴とする、請求項9に記載の吸入器。
- 1つのピン、又は、複数のピン(6)が、側面に沿って取り付けられたガイドアーム(18)を通して案内されることを特徴とする、請求項9又は10に記載の吸入器。
- 取り付けられた前記ガイドアームが、プレテンション下で前記二重機能作動部材(7)を側面で保持することを特徴とする、請求項11に記載の吸入器。
- 粉末薬剤組成物を吸入するための請求項1に記載の吸入器。
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