JP4884020B2 - Medical auxiliary adhesive tape - Google Patents

Description

  The present invention relates to a medical auxiliary pressure-sensitive adhesive tape of a type in which an acrylic pressure-sensitive adhesive layer is formed on one side of a support made of a polyolefin-based nonwoven fabric. The adhesive tape for medical assistance of the present invention is used as medical assistance, for example, fixing of gauze, bandages, catheters, infusion tubes, blood transfusion tubes, etc., wound treatment and protection, hemostasis, and surgical site coating. is there.

  The medical auxiliary pressure-sensitive adhesive tape is used, for example, for fixing absorbent cotton, gauze, bandage, catheter, blood transfusion tube, shipping agent, etc. to the human body at the time of treatment in the medical field or at home. The medical auxiliary pressure-sensitive adhesive tape generally has a structure in which an adhesive layer is formed on one side of a support. As the support, for example, plastic films such as vinyl chloride, polyethylene, and polypropylene, papers such as Japanese paper, and nonwoven fabric made of fibers such as polypropylene, polyurethane, and polyester are used.

  In addition to the fixing function using adhesiveness, the medical auxiliary adhesive tape may have elasticity that can follow the movement of the applied skin surface and moisture permeability to prevent sweat from accumulating on the applied site due to sweating. It has been demanded. The medical auxiliary pressure-sensitive adhesive tape is usually used after being cut to a desired length, but from the viewpoint of ease of use, it is required to have a hand cutting property that can be easily cut using a hand.

  Although the medical assistance adhesive tape using films as a support generally has stretchability, it is inferior in hand cutting and moisture permeability. Generally, a medical auxiliary pressure-sensitive adhesive tape using paper as a support has hand stretchability and moisture permeability, but lacks stretchability. A medical auxiliary pressure-sensitive adhesive tape using a nonwoven fabric as a support is excellent in moisture permeability and stretchability, but generally has poor hand cutting properties.

  In view of this, JP-A-2002-360625 (Patent Document 1) proposes an adhesive tape for skin application in which an adhesive layer is provided on one side of a support made of a polyolefin nonwoven fabric that has been perforated. Specifically, in Patent Document 1, in the adhesive tape for skin application in which an adhesive layer is provided on one side of the support, the support is a polyolefin nonwoven fabric, and the polyolefin nonwoven fabric includes a large number of penetrating or non-penetrating materials. An adhesive tape for skin application in which micropores are formed and the nonwoven fabric fibers around the micropores are melted to form a film is disclosed.

  Patent Document 1 discloses that isocyanate-based cross-linking is carried out in a solution of isononyl acrylate / methoxynonaethylene glycol acrylate / nonaethylene glycol methacrylate (83/16/1% by weight) copolymer with a solid content of 100 parts by weight. The Example which formed the adhesive layer on the polyolefin nonwoven fabric using the adhesive solution which added 0.6 weight part of agents was shown.

  In addition to being excellent in stretchability and moisture permeability, the adhesive tape for skin application described in Patent Document 1 has excellent stretchability and moisture permeability because the hand cutting property is improved by perforation treatment. Since the hand cutting property is improved, it is suitable as an adhesive tape for medical assistance.

  Medical auxiliary adhesive tape not only has excellent adhesion to the skin and fixability to medical devices, but also has excessively high adhesion to the skin surface to prevent pain and exfoliation when peeling from the skin surface. It is required to adjust so that it does not become. For such a requirement, for example, a known method (for example, Patent Document 2) in which a liquid component such as isopropyl myristate is blended with an acrylic pressure-sensitive adhesive may be employed.

  On the other hand, since a medical auxiliary pressure-sensitive adhesive tape is often used by being overlaid, it is required that the overlapping portion is not peeled off. For example, in order to fix a medical device such as a gauze, a blood transfusion tube, or an infusion tube to a person's arm, it is necessary to apply a medical auxiliary pressure-sensitive adhesive tape repeatedly and fix them securely. If the overlapped portion is easily peeled off, the fixing function of the medical auxiliary adhesive tape is hindered. However, according to the study results of the present inventors, the acrylic pressure-sensitive adhesive layer containing a general-purpose liquid component such as isopropyl myristate is against the back surface (the surface opposite to the pressure-sensitive adhesive layer of the polyolefin-based nonwoven fabric). It was found that the adhesive strength was weak, and floating and peeling were likely to occur in the overlapped portion.

JP 2002-360625 A JP-A-5-65460

  An object of the present invention is a medical auxiliary pressure-sensitive adhesive tape in which an acrylic pressure-sensitive adhesive layer is formed on one side of a support made of a polyolefin-based non-woven fabric, the adhesiveness to the skin, the fixability of a medical device, and the overlapped portion An object of the present invention is to provide a medical auxiliary pressure-sensitive adhesive tape having excellent peeling prevention properties.

  Another object of the present invention is to provide a medical auxiliary pressure-sensitive adhesive tape that does not turn yellow over time in addition to being excellent in the various properties as described above.

  Furthermore, the subject of this invention is providing the adhesive tape for medical assistance which has the support body which consists of a polyolefin-type nonwoven fabric by which the perforation process was carried out, and was excellent also in hand cutting property.

  As a result of diligent research to solve the above-mentioned problems, the present inventors have blended an acrylic oligomer with an acrylic oligomer instead of a conventional liquid component such as isopropyl myristate, and further blended a tackifier resin. It has been found that by providing a pressure-sensitive adhesive layer on one side of a polyolefin-based nonwoven fabric, a medical auxiliary pressure-sensitive adhesive tape excellent in the above-mentioned characteristics can be obtained with the above-mentioned pressure-sensitive adhesive composition. When a hydrogenated aromatic modified terpene resin is used as a tackifier resin, yellowing over time can be more effectively prevented. The present invention has been completed based on these findings.

According to the present invention, one side of a support comprising a polyolefin-based nonwoven fabric, (a) an acrylic adhesive, (b) acrylic oligomer, (c) a rosin resins, terpene resins, C ₅ petroleum resins, C A pressure-sensitive adhesive layer comprising a _9- based petroleum resin, a phenol resin, a rosin-modified phenol resin, a xylene resin, an alicyclic hydrogenated petroleum resin, or a coumarone-indene resin , and (d) a cross-linking agent. A formed adhesive tape for medical assistance ,
(I) The pressure-sensitive adhesive layer contains 7 to 25 parts by weight of an acrylic oligomer, 7 to 25 parts by weight of a tackifier resin, and 0.01 to 3 parts by weight of a crosslinking agent with respect to 100 parts by weight of the acrylic pressure-sensitive adhesive. A layer formed from a pressure-sensitive adhesive composition, and
(Ii) As a measurement method, the test atmosphere which is the medical auxiliary pressure-sensitive adhesive tape cut at a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5% and a width of 25 mm, with the pressure-sensitive adhesive side facing down, Measured by a measurement method in which the back surface of the medical auxiliary pressure-sensitive adhesive tape is pressure-bonded with a roller, the play portion of the test piece is folded back 180 degrees, peeled off at a peeling speed of 300 mm / min, and peeled off 180 degrees. There is provided a medical auxiliary pressure-sensitive adhesive tape in which the self-back adhesive force of the medical auxiliary pressure-sensitive adhesive tape is 0.70 to 1.35 N / 25 mm .

  ADVANTAGE OF THE INVENTION According to this invention, the adhesive tape for medical assistance excellent in the adhesiveness with respect to skin, the fixability of a medical device, and the peeling prevention property of a laminated part is provided. Moreover, according to this invention, the adhesive tape for medical assistance in which yellowing with time was prevented is provided. Furthermore, according to this invention, in addition to being excellent in the said various characteristics, the adhesive tape for medical assistance with favorable hand cutting property is provided.

  In the present invention, a polyolefin-based nonwoven fabric is used as the support. By using a polyolefin-based nonwoven fabric as a support, a medical auxiliary pressure-sensitive adhesive tape having good stretchability and moisture permeability can be obtained. In addition, by performing perforation treatment as disclosed in JP-A-2002-360625 (Patent Document 1) on the back surface of the polyolefin nonwoven fabric (the surface opposite to the pressure-sensitive adhesive layer), Can be improved. In addition, by performing perforation treatment on the back surface of the polyolefin-based nonwoven fabric, it is possible to exhibit appropriate releasability without applying a release agent.

  The polyolefin nonwoven fabric is not particularly limited as long as it is a nonwoven fabric manufactured using polyolefin fibers. The method for producing the polyolefin-based nonwoven fabric is not particularly limited, and wet methods, dry methods, and other methods can be employed. Examples of the dry method include a chemical bond method in which a fiber web is bonded with an adhesive, a thermal bond method in which self-adhesive or bonded fibers are bonded. Other manufacturing methods include a spunbond method, a melt blown method, and a needle punch method. Of these non-woven fabric production methods, the spunbond method is preferred.

  In the spunbond method, generally, a large number of filaments are extruded from a spinneret having a large number of fine holes similar to shower nozzles, and collected on a running belt to form a web. The filaments in the high temperature state form a nonwoven fabric by thermally fusing the filaments together. It is desirable to emboss at the time of heat sealing. The filament is usually a continuous filament.

  Examples of the polyolefin resin include polyethylene, polypropylene, ethylene-propylene copolymer, ethylene-α-olefin copolymer, and mixtures thereof. Among these, polypropylene or a blend containing polypropylene as a main component (for example, a blend of polypropylene and polyethylene) is preferable.

The basis weight of the polyolefin-based nonwoven fabric is preferably 20 to 250 g / m ² , more preferably 25 to 75 g / m ² . The thickness of the polyolefin nonwoven fabric is preferably 0.15 to 0.90 mm, more preferably 0.18 to 0.60 mm. By setting the basis weight and thickness of the polyolefin nonwoven fabric within the above ranges, the strength, breathability (moisture permeability), texture, stretchability, etc. required for medical auxiliary pressure-sensitive adhesive tapes can be highly balanced. But it is advantageous.

  The acrylic pressure-sensitive adhesive used in the present invention is an acrylic acid ester copolymer having an alkyl group having 1 to 18 carbon atoms, preferably 4 to 12 alkyl acrylates as a main component.

  Examples of the alkyl acrylate ester include methyl acrylate, ethyl acrylate, n-butyl acrylate, isobutyl acrylate, t-butyl acrylate, n-hexyl acrylate, n-octyl acrylate, and acrylic acid-2- Examples include ethylhexyl, isooctyl acrylate, isononyl acrylate, n-decyl acrylate, isodecyl acrylate, lauryl acrylate, stearyl acrylate, and the like.

  These acrylic acid esters can be used alone or in combination of two or more. Among these acrylate esters, 2-ethylhexyl acrylate, n-octyl acrylate, isooctyl acrylate, and isononyl acrylate are preferable.

  The acrylic ester copolymer is a copolymer having an acrylic ester as a main component as a monomer, and can thereby exhibit characteristics as an acrylic pressure-sensitive adhesive. The copolymerization ratio of the acrylic acid alkyl ester is preferably 60 to 95% by weight, more preferably 65 to 90% by weight.

  As a comonomer copolymerized with alkyl acrylate, a vinyl monomer having a functional group is preferable. Specific examples thereof include acrylic acid esters having a hydroxyl group such as 2-hydroxyethyl acrylate, 3-hydroxypropyl acrylate, 4-hydroxybutyl acrylate; acrylic acid, methacrylic acid, maleic acid, maleic anhydride, Vinyl monomers having a carboxyl group such as itaconic acid and monobutyl maleate; Vinyl monomers having an amide group such as acrylamide, dimethylacrylamide, diethylacrylamide, methacrylamide and N-methylolacrylamide; Vinyl having an amino group such as dimethylaminoethyl acrylate Monomers; vinyl monomers having an epoxy group such as glycidyl acrylate and glycidyl methacrylate; vinyl monomers having a pyrrolidone ring such as N-vinylpyrrolidone; 2-methoxyethylene acrylate Le, alkoxyalkyl acrylate esters, such as acrylic acid ethoxyethyl; and the like.

  These monomers having functional groups can be used alone or in combination of two or more. The copolymerization ratio of the monomer having a functional group in the acrylate copolymer is preferably 1 to 40% by weight, more preferably 5 to 35% by weight.

  Other comonomers include methyl methacrylate, ethyl methacrylate, n-butyl methacrylate, isobutyl methacrylate, t-butyl methacrylate, n-hexyl methacrylate, n-octyl methacrylate, 2-ethylhexyl methacrylate, methacrylic acid Methacrylic acid alkyl esters such as isooctyl, isononyl methacrylate, n-decyl methacrylate, isodecyl methacrylate, lauryl methacrylate and stearyl methacrylate; vinyl esters such as vinyl acetate; unsaturated nitriles such as acrylonitrile and methacrylonitrile; styrene Vinyl aromatic compounds such as;

  Other comonomers can be used alone or in combination of two or more. The copolymerization ratio of other monomers in the acrylate copolymer is preferably 0 to 30% by weight.

  The acrylic pressure-sensitive adhesive used in the present invention comprises 60 to 95% by weight of an alkyl acrylate ester having an alkyl group having 4 to 12 carbon atoms, 4 to 35% by weight of an alkoxyalkyl acrylate ester, and 1 to 1 carboxyl group-containing vinyl monomer. A copolymer of 5% by weight is preferred, and a copolymer of 4 to 12 carbon alkyl acrylates of 65 to 90% by weight, acrylic acid alkoxy alkyl esters of 9 to 34% by weight, and carboxyl group-containing vinyl monomers of 1 to 3% by weight. A polymer is more preferred. By using such an acrylic copolymer as a base of the pressure-sensitive adhesive, it is possible to highly balance skin adhesiveness, fixing function and the like. These copolymers are acrylic copolymers having a crosslinkable functional group.

  The weight average molecular weight of the acrylic pressure-sensitive adhesive is preferably 300,000 to 1,000,000, more preferably 450,000 to 650,000. By setting the weight average molecular weight of the acrylic pressure-sensitive adhesive within the above range, it is possible to balance cohesion, adhesiveness, mixing workability with other components, affinity with other components, and the like. The weight average molecular weight of the acrylic pressure-sensitive adhesive is a value obtained as a standard polystyrene conversion value by a gel permeation chromatography (GPC) method.

  In general, the acrylate copolymer can be synthesized by radical polymerization. Examples of the polymerization method include a solution polymerization method, an emulsion polymerization method, a bulk polymerization method, and the like, but a solution polymerization method is preferable because good adhesive properties can be easily obtained. Examples of the polymerization initiator include organic peroxides such as benzoyl peroxide and lauroyl peroxide; azo initiators such as azobisisobutyronitrile; and the like. A radical polymerization initiator is added at a ratio of about 0.1 to 3% by weight with respect to all monomers, and the mixture is stirred for several hours to several tens of hours at a temperature of about 40 to 90 ° C. in a nitrogen stream. In the solution polymerization method, ethyl acetate, acetone, toluene, a mixture thereof or the like is widely used as a solvent.

  Various crosslinking agents can be used to increase the cohesive strength of the acrylic pressure-sensitive adhesive. Examples of the crosslinking agent include polyfunctional isocyanate compounds, polyfunctional epoxy compounds, and polyvalent metal salts. When the crosslinking agent is added to the acrylic pressure-sensitive adhesive, the use ratio thereof is preferably 0.01 to 3 parts by weight, more preferably 0.02 to 2 parts by weight, particularly 100 parts by weight of the acrylic pressure-sensitive adhesive. Preferably it is 0.03-1 weight part. If the use ratio of the crosslinking agent is too small, the effect of improving the cohesive force is reduced, and if it is excessive, the cohesive force is excessively increased.

  In this invention, an acrylic oligomer is mix | blended with an acrylic adhesive. The number average molecular weight of the acrylic oligomer is preferably 500 to 50,000, more preferably 800 to 20,000, and particularly preferably 1,000 to 10,000. The number average molecular weight of the acrylic oligomer is a value obtained as a standard polystyrene equivalent value by gel permeation chromatography (GPC) method.

  The acrylic oligomer is preferably liquid at normal temperature (25 ° C.), and the viscosity at 25 ° C. (measured with a B-type viscometer) is preferably 300 to 15,000 mPa · s, more preferably 350 to 10 1,000 mPa · s. The glass transition temperature (Tg) of the acrylic oligomer measured using a differential scanning calorimeter (DSC) is preferably in the range of -70 ° C to -10 ° C. Since the acrylic oligomer has the above-mentioned number average molecular weight and various properties, it has excellent compatibility with the acrylic pressure-sensitive adhesive.

  In general, the acrylic oligomer has an alkyl group having 1 to 18 carbon atoms, preferably 2 to 14 carbon atoms, more preferably 4 to 10 alkyl acrylates and / or methacrylic acid alkyl esters (hereinafter referred to as “acrylic monomers”). ) Is a low molecular weight acrylic polymer obtained by polymerization. Examples of the acrylic monomer include methyl acrylate, ethyl acrylate, propyl acrylate, isopropyl acrylate, n-butyl acrylate, isobutyl acrylate, t-butyl acrylate, n-hexyl acrylate, and n-acrylate. Acrylic acid alkyl esters such as octyl, 2-ethylhexyl acrylate, isooctyl acrylate, isononyl acrylate, nonyl acrylate; methyl methacrylate, ethyl methacrylate, propyl methacrylate, isopropyl methacrylate, n-butyl methacrylate, methacryl Isobutyl acid, t-butyl methacrylate, n-hexyl methacrylate, n-octyl methacrylate, 2-ethylhexyl methacrylate, isooctyl methacrylate, isononyl methacrylate, methacrylic acid Methacrylic acid alkyl esters, such as alkylsulfonyl; and the like.

  The acrylic oligomer can be synthesized by homopolymerizing or copolymerizing an acrylic monomer using a chain transfer agent such as lauryl mercaptan or mercaptoethanol. In recent years, a technique for producing an acrylic oligomer having a low molecular weight and a low viscosity by continuously polymerizing an acrylic monomer at a high temperature and a high pressure without using a chain transfer agent has been developed. The acrylic oligomer may be copolymerized with a monomer containing a functional group to introduce a functional group such as a hydroxyl group, a carboxyl group, or a glycidyl group, but a non-functional oligomer is usually preferable.

  A commercial item can be used as an acrylic oligomer. An example of such a commercial product is JDX-P series sold by Johnson Polymer Co., Ltd. Specifically, JDX-P1000 (molecular weight = 3,000, viscosity = 1,000 mPa · s, Tg = −60 ° C.), JDX-P1010 (molecular weight = 1,500, viscosity = 4,000 mPa · s, Tg = −32 ° C.), JDX-P1020 (molecular weight = 1,500, viscosity = 400 mPa · s, Tg = −66 ° C.), JDX-P1030 (molecular weight = 4,000, viscosity = 10,000 mPa · s, Tg = −57). ° C), JDX-P1060 (molecular weight = 2,200, viscosity = 900 mPa · s, Tg = −59 ° C.), JDX-P1070 (molecular weight = 2,000, viscosity = 3,800 mPa · s, Tg = −43 ° C.) Etc.

In this invention, tackifying resin is mix | blended with an acrylic oligomer with respect to an acrylic adhesive. Examples of tackifying resins include rosin resins such as rosin, hydrogenated rosin, and hydrogenated rosin ester; terpene resins, hydrogenated terpene resins, terpene phenol resins, aromatic modified terpene resins, hydrogenated aromatic modified terpene resins, and the like. terpene resins; C ₅ petroleum resins, C ₉ petroleum resins, phenol resins, rosin-modified phenolic resin, xylene resin, alicyclic hydrogenated petroleum resins, such as coumarone-indene resins.

  Among these tackifying resins, terpene resins such as terpene resins, hydrogenated terpene resins, terpene phenol resins, aromatic modified terpene resins, hydrogenated aromatic modified terpene resins are preferable, and yellowing over time is suppressed. Hydrogenated terpene resins and hydrogenated aromatic modified terpene resins are more preferred, and hydrogenated aromatic modified terpene resins are particularly preferred. The aromatic modified terpene resin is a resin obtained by copolymerizing an aromatic monomer and a terpene monomer. The hydrogenated aromatic modified terpene resin is a resin obtained by hydrogenating an aromatic modified terpene resin. The hydrogenated aromatic modified terpene resin is particularly preferable for the use of the present invention because it has a good tackifying effect, has a colorless and transparent hue, and is excellent in thermal stability and weather resistance.

In this invention, the layer which consists of an adhesive composition containing an acrylic adhesive, an acrylic oligomer, and tackifying resin is formed in the single side | surface of the support body which consists of a polyolefin-type nonwoven fabric, and the adhesive tape for medical assistance is produced. . The blending ratio of each component in the pressure-sensitive adhesive composition is preferably 5 to 30 parts by weight, more preferably 7 to 25 parts by weight, particularly preferably 10 to 20 parts by weight based on 100 parts by weight of the acrylic pressure-sensitive adhesive. The amount of the tackifier resin is preferably 5 to 25 parts by weight, more preferably 7 to 20 parts by weight, and particularly preferably 10 to 15 parts by weight. Acrylic pressure-sensitive adhesive generally has poor cohesive force, and the pressure-sensitive adhesive may remain on the skin surface at the time of peeling. Therefore, it is preferable to add a cross-linking agent composed of a polyfunctional compound to the pressure-sensitive adhesive composition for crosslinking. . Therefore, the pressure-sensitive adhesive composition preferably contains the above-described crosslinking agent. The pressure-sensitive adhesive layer of the present invention contains 7 to 25 parts by weight of an acrylic oligomer, 7 to 25 parts by weight of a tackifier resin, and 0.01 to 3 parts by weight of a crosslinking agent with respect to 100 parts by weight of the acrylic pressure-sensitive adhesive. It is a layer formed from an adhesive composition.

  In the present invention, the reason why the acrylic oligomer is used is that the adhesiveness to the skin surface of the acrylic pressure-sensitive adhesive layer is not excessively increased, and when the pressure-sensitive adhesive tape is overlaid, This is because the effect of preventing floating and peeling is remarkable.

  When the acrylic pressure-sensitive adhesive layer of the pressure-sensitive adhesive tape contains a general-purpose liquid component such as isopropyl myristate, the adhesiveness to the skin surface is appropriately adjusted, and the fixing function to the medical device is exhibited. However, when this adhesive tape is laminated, the adhesiveness to the back surface is insufficient, so that it tends to float or peel off. General-purpose liquid components such as isopropyl myristate have insufficient compatibility with acrylic adhesives. Therefore, if the acrylic pressure-sensitive adhesive layer of the pressure-sensitive adhesive tape contains, for example, isopropyl myristate, a thin layer of isopropyl myristate is formed on the surface of the pressure-sensitive adhesive layer. It is estimated that the adhesiveness to the surface of the nonwoven fabric is greatly reduced.

  In contrast, acrylic oligomers are generally liquid, but have excellent compatibility with acrylic adhesives, and are thin films on the surface of the adhesive layer, such as general-purpose liquid components such as isopropyl myristate. And the adhesiveness to the back surface is not greatly reduced. Although the acrylic oligomer is excellent in compatibility with the acrylic pressure-sensitive adhesive, the pressure-sensitive adhesive properties such as the pressure-sensitive adhesive force and the holding power of the pressure-sensitive adhesive tape can be maintained at a level required for a medical auxiliary pressure-sensitive adhesive tape.

  By blending the tackifier resin with the acrylic pressure-sensitive adhesive, it is possible to sufficiently exert the adhesiveness to the skin and the fixing function to the medical device required for the medical auxiliary pressure-sensitive adhesive tape.

  If the blending ratio of the acrylic oligomer is too small or too large, the self-back surface adhesive strength of the adhesive tape tends to decrease. If the blending ratio of the tackifying resin is too small, the effect of improving the adhesive properties (adhesive strength, holding power) is small, and if it is too large, the compatibility with the acrylic pressure-sensitive adhesive decreases, and the adhesive properties tend to decrease.

  As an acrylic pressure-sensitive adhesive, a predetermined amount of each monomer is dissolved in an organic solvent, purged with nitrogen, stirred at an elevated temperature, polymerized using a reaction initiator such as peroxide, and then directly or organically. Those diluted with a solvent can be used. The acrylic oligomer and tackifying resin are added to the acrylic pressure-sensitive adhesive solution. In order to improve moisture permeability and air permeability, the acrylic pressure-sensitive adhesive may contain fine bubbles in the pressure-sensitive adhesive in the pressure-sensitive adhesive layer forming step.

  In pressure-sensitive adhesive processing to a support made of polyolefin-based non-woven fabric, first, a pressure-sensitive adhesive composition solution is applied onto a release paper on which a release material such as silicone resin is applied to a paper substrate, and then dried to form a pressure-sensitive adhesive layer. To do. Next, the pressure-sensitive adhesive layer on the release paper is bonded to the surface of the polyolefin-based nonwoven fabric, and the pressure-sensitive adhesive layer is transferred onto the polyolefin-based nonwoven fabric. Release paper is removed at an appropriate stage in the process. The pressure-sensitive adhesive tape is wound into a roll so that the pressure-sensitive adhesive layer overlaps the back surface of the polyolefin-based nonwoven fabric in the final step, and is used as the pressure-sensitive adhesive tape original fabric. The pressure-sensitive adhesive tape original is usually cut into a predetermined width before being wound into a roll or after being wound into a roll. The coating thickness of the pressure-sensitive adhesive is usually 20 to 100 μm, preferably 30 to 70 μm after drying.

The polyolefin nonwoven fabric is preferably embossed in advance. A known apparatus and method can be adopted for embossing. As the embossing method, for example, a point heat pressing method can be employed. By forming 10 or more heat fusion points per 1 cm ² by embossing, the strength of the nonwoven fabric can be supplemented. By embossing, a large number of fine irregularities are formed on the back surface (the surface opposite to the surface on which the pressure-sensitive adhesive layer is formed) of the nonwoven fabric to be the support. In order to form such fine irregularities, for example, an embossing roll having an irregular pattern on the surface and an anvil roll are made to face each other, a nonwoven fabric is passed between both rolls, and a method of pressing under heating is adopted. Is preferred.

  The embossing pattern is not particularly limited as long as it has a shape in which a large number of fine irregularities are formed on the surface opposite to the surface to which the embossing roll of the nonwoven fabric comes into contact. For example, a lattice pattern, a large number of short lines are staggered There are a pattern in which a large number of short lines are combined vertically and horizontally, a pattern in which a large number of small circles are arranged, and the like. Among these embossed patterns, a lattice pattern having a large number of recesses defined by intersecting ridge lines (projections) is preferable. The line width of the ridge lines is 150 to 600 μm, the distance between the ridge lines (width of the recesses) is 0.5 to 1.5 mm, and the depth of the recesses is preferably 50 to 400 μm. The total area of the protrusions (ridges and the like) that are raised on the back surface of the nonwoven fabric serving as the support is usually 50% or less, preferably 40% or less, more preferably 30% or less of the total area of the nonwoven fabric. The lower limit of the total area of the recesses is preferably about 5%, more preferably about 10%. When the emboss pattern exists, the balance between the rewinding property from the roll of the adhesive tape and the overlaying property becomes good. Such embossing is described in detail in Japanese Patent Laid-Open No. 2004-229830, and the disclosure of the gazette is incorporated herein by reference.

  In the present invention, it is preferable to perform perforation treatment on the support surface side (back surface side) of the pressure-sensitive adhesive tape provided with the pressure-sensitive adhesive layer on one side of the support made of polyolefin-based nonwoven fabric. More specifically, by performing perforation treatment as disclosed in Japanese Patent Application Laid-Open No. 2002-360625 (Patent Document 1), hand tearability can be improved, and a release agent is not applied. It is possible to exhibit moderate peelability. Peelability can be further improved by combining perforation and embossing. Moreover, the pressure-sensitive adhesive tape of the present invention has moderately maintained adhesiveness to such a back surface, and does not easily float or peel off even if it is laminated.

  In order to perform perforation treatment from the polyolefin nonwoven fabric side of the adhesive tape, a punching means having a large number of protrusions is pressure-bonded from the surface of the polyolefin nonwoven fabric while heating the temperature of the protrusions to a temperature around the melting point of the polyolefin, A large number of micropores that penetrate or do not penetrate the polyolefin nonwoven fabric are formed. This method is called a heat drilling method. By this thermal perforation method, the nonwoven fabric fibers (typically filaments) around the micropores are melted to form a film.

  As the perforating means, for example, it is preferable to use a perforating roll provided with a large number of protrusions on the surface for continuous production. A heater or a heat medium is incorporated inside the perforating roll to control the temperature of the protrusions and the surface of the perforating roll. In addition, an endless belt provided with a large number of protrusions may be used. The perforation is preferably continuously performed on a medical auxiliary pressure-sensitive adhesive tape using a polyolefin-based nonwoven fabric as a support. As a method for forming the microholes, a punching roll and a pressure roll are arranged opposite to each other in the middle of the feeding portion and the winding portion of the adhesive tape, and the adhesive tape original is placed between the contact surfaces of both rolls. A method of continuous thermal drilling is preferred. The thermal perforation can be performed after removing the release paper, but may be performed with the release paper attached. If release paper is present on the surface of the pressure-sensitive adhesive layer, the release paper acts as a cushion material during thermal perforation.

  The shape of the protrusions provided on the surface of the punching means such as a punching roll is not particularly limited, but each micropore formed in the support is a hole shape (angular with both ends being acute or obtuse in the tearing direction. It is desirable to have a protrusion shape that leads to a hole shape. The tearing direction is preferably the width direction of the adhesive tape or the support.

  The length of the bottom of the protrusion is preferably 0.3 to 2 mm, more preferably 0.5 to 1 mm, and the height is preferably 0.2 to 1.5 mm, more preferably 0.3 to 1 mm. Degree. When the protrusion is a square weight, the diagonal length of the bottom surface of the quadrangle is preferably selected from 0.3 to 2 mm, more preferably from 0.5 to 1 mm, and the height is preferably from 0.2 to 1.5 mm. More preferably, it is selected from 0.3 to 1 mm. The interval (pitch) between the protrusions in the row and the interval (pitch) between the rows are both preferably about 0.3 to 10 mm, more preferably about 0.5 to 8 mm.

The adhesive tape for medical assistance of the present invention usually has an adhesive strength to stainless steel of 0.50 to 2.50 N / 25 mm, an adhesive strength to polypropylene of 0.50 to 2.00 N / 25 mm, and a holding force of 0.1 to 0. 4. Adhesive property of 4 mm. The adhesive tape for medical assistance of the present invention has a self-rear surface adhesive strength of 0.70 N / 25 mm or more, preferably 0.90 to 1.35 N / 25 mm, more preferably 0.95 to 1.30 N / 25 mm. In the present invention, it is 0.70 to 1.35 N / 25 mm.

  The medical auxiliary pressure-sensitive adhesive tape of the present invention is a form in which the pressure-sensitive adhesive tape is wound into a roll, and is subjected to a forced deterioration test for 3 days at a temperature of 100 ° C. in a dry heat atmosphere. When observed, it is preferable to maintain the white color without yellowing. The medical auxiliary pressure-sensitive adhesive tape of the present invention is unlikely to float or peel off at the overlapped portion in a practical test described below.

  Since the medical auxiliary pressure-sensitive adhesive tape of the present invention uses a polyolefin-based nonwoven fabric as a support, it has good moisture permeability and stretchability, and the perforated product has excellent hand cutting properties.

  Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples. The measuring methods of physical properties and characteristics are as follows.

(1) Molecular Weight The weight average molecular weight of the acrylic pressure-sensitive adhesive and the number average molecular weight of the acrylic oligomer are values obtained as standard polystyrene equivalent values by gel permeation chromatography (GPC).

(2) Self-back surface adhesive strength The self-back surface adhesive strength of the adhesive tape was measured by the 180-degree peeling method defined in JIS Z 0237. Specifically, the pressure-sensitive adhesive tape (test piece) cut to a width of 25 mm is pressure-bonded with a roller to the back surface (support surface) of the same pressure-sensitive adhesive tape sample with the pressure-sensitive adhesive surface facing down, The part was folded back at 180 degrees, and peeled off at 180 degrees at a peeling speed of 300 mm / min. The measurement atmosphere was a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5%. If the self-adhesive strength is 0.70N / 25mm or more, the adhesive layer may be peeled off due to rubbing with the clothes on the adhesive tape during actual use of the adhesive tape, or may float at the end of the adhesive layer Is sufficiently suppressed.

(3) Adhesive strength to stainless steel The adhesive strength of a 25 mm wide adhesive tape to stainless steel was measured by the 180-degree peeling method defined in JIS Z 0237. The peeling speed was 300 mm / min. The measurement atmosphere was a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5%.

(4) Adhesive strength against PP The adhesive strength of a 25 mm wide adhesive tape to a polypropylene panel was measured by a 180-degree peeling method defined in JIS Z 0237. The peeling speed was 300 mm / min. The measurement atmosphere was a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5%.

(5) Holding force The holding force of the adhesive tape of width 25mm was measured by the measuring method prescribed | regulated to JISZ0237. Affixed to the test plate so that the area of 25 mm x 25 mm of the adhesive tape test piece is in contact, after pressing with a roller, one end of the test plate is fastened with a clasp so that the adhesive tape test piece hangs vertically, and the lower end The distance (mm) shifted after a predetermined time was measured by applying a predetermined load to the surface. Roller mass = 2000 ± 50 g, crimping speed = 300 mm / min, number of crimps = 1 reciprocation, standing time after crimping = 30 minutes, load = 200 gf. The measurement atmosphere was a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5%.

(6) Practical test A blood circuit for artificial kidneys having a diameter of 6 mm was placed on a human forearm and fixed to the skin surface with two partially overlapping adhesive tapes. Specifically, as shown in FIG. 1, an adhesive tape 11 having a width of 25 mm is applied from above the artificial kidney blood circuit 2 placed on a human forearm, and the same width is applied to the back surface of the adhesive tape 11. The artificial kidney blood circuit 2 was fixed to the skin surface by sticking the adhesive surface of the 25 mm adhesive tape 12 so that the 10 mm portion 13 overlapped. The length of the skin surface was 20 mm on each side of the artificial kidney blood circuit. After the artificial kidney blood circuit 2 was affixed with the test piece 1 on which two adhesive tapes 11 and 12 were partially affixed and fixed to the skin surface, the subject performed general office work.

Two hours after application, the fixed state was observed. In particular, whether or not the end portion (edge portion) 14 of the adhesive tape 12 in the overlapped portion of the test piece 1 was lifted or peeled was visually observed. Since the subject performed general office work after application, the load on the adhesive tape application part was applied by the movement of the arm, and the adhesive tape rubbed with the clothing. Peeling easily occurs. In the practical test, the evaluation was made according to the following evaluation criteria.
○: There is no floating at the edge of the overlapped part,
X: A float is seen in the edge part of the overlapped part.

(7) Color tone In a form in which the pressure-sensitive adhesive tape was wound up in a roll shape, a forced deterioration test was conducted for 3 days at a temperature of 100 ° C. in a dry heat atmosphere, and the color tone after the test was visually observed.

[Example 1]
An acrylic pressure-sensitive adhesive (acrylic copolymer) obtained by radical polymerization of a monomer mixture containing 68 parts by weight of isononyl acrylate, 30 parts by weight of 2-methoxyethyl acrylate, and 2 parts by weight of acrylic acid in ethyl acetate. Polymer: Weight average molecular weight = about 550,000) 100 parts by weight of solid content of the solution, acrylic oligomer (manufactured by Johnson Polymer Co., Ltd., trade name “JDX-P1020”; number average molecular weight = 1,500, Tg = Viscosity at −66 ° C. and 25 ° C. = 400 mPa · s) 15 parts by weight, hydrogenated aromatic modified terpene resin (manufactured by Yashara Chemical Co., Ltd., trade name “CLEARON K-4090”), and epoxy crosslinking agent ( 0.05 parts by weight of Mitsubishi Gas Chemical Co., Ltd., trade name “Tetrad X”) was added to prepare an adhesive composition solution (concentration 30% by weight). It was. This pressure-sensitive adhesive composition solution was applied on a release paper having a surface treated with silicone so that the thickness after drying was 38 μm, and dried at 120 ° C. for 3 minutes. Thus, the adhesive composition layer was formed on the release paper.

On the other hand, a polypropylene-based nonwoven fabric manufactured by the spunbond method (made by Idemitsu Unitech Co., Ltd., trade name “Stratec PP RN2040”; basis weight = 40 g / m ² , thickness = 0.27 mm) Passing between the anvil rolls, a grid pattern was heated and embossed. The grid-like embossing pattern on the side in contact with the anvil roll has a ridge line width of 300 μm, a ridge line interval (recess width) of 1.1 mm, and a recess depth of 150 μm, and a protrusion raised on the back of the nonwoven fabric. The total area of the parts (ridge lines) was about 25% of the total area of the nonwoven fabric.

  The surface of the surface of the perforated roll is 145 between the perforated roll and the stainless steel roll, on which the embossing roll contact surface side of the polypropylene nonwoven fabric is bonded to the pressure-sensitive adhesive composition layer, and then a large number of quadrangular pyramidal protrusions are provided. By passing a pressure of 0.9 MPa between the rolls at 0 ° C., a large number of rhombus-shaped micropores were formed on the back surface of the polyolefin nonwoven fabric on which the pressure-sensitive adhesive composition layer was not formed. The shape of the quadrangular pyramid protrusions provided on the perforated roll has a bottom width of 0.6 mm in the roll width direction, a rotation direction length of 0.8 mm, and a protrusion height of 0.5 mm. there were. The pitch of the protrusions was 0.8 mm in the roll width direction and 1.1 mm in the rotation direction. Next, while removing the release paper, the pressure-sensitive adhesive sheet provided with the pressure-sensitive adhesive composition layer on one side of the polyolefin-based nonwoven fabric was wound on a roll and cut into a size of 25 mm in width to produce a pressure-sensitive adhesive tape.

  The adhesive tape thus obtained had good adhesiveness to the skin. The self-back surface adhesive strength of this adhesive tape was 1.25 N / 25 mm. In the practical test of this pressure-sensitive adhesive tape, no floating or peeling of the overlapped portion was observed. This pressure-sensitive adhesive tape was wound up in a roll shape, and did not change in color tone without yellowing after forced deterioration at 100 ° C. for 3 days. The results are shown in Table 1.

[Example 2]
In Example 1, an adhesive tape was produced in the same manner as in Example 1 except that the blending ratio of the acrylic oligomer was changed from 15 parts by weight to 10 parts by weight. The adhesive tape thus obtained had good adhesiveness to the skin. The self-back surface adhesive strength of this adhesive tape was 1.05 N / 25 mm. In the practical test of this pressure-sensitive adhesive tape, no floating or peeling of the overlapped portion was observed. This pressure-sensitive adhesive tape was wound up in a roll shape, and did not change in color tone without yellowing after forced deterioration at 100 ° C. for 3 days. The results are shown in Table 1.

[Example 3]
In Example 1, an adhesive tape was produced in the same manner as in Example 1 except that the blending ratio of the acrylic oligomer was changed from 15 parts by weight to 20 parts by weight. The adhesive tape thus obtained had good adhesiveness to the skin. The self-back surface adhesive strength of this adhesive tape was 1.01 N / 25 mm. In the practical test of this pressure-sensitive adhesive tape, no floating or peeling of the overlapped portion was observed. This pressure-sensitive adhesive tape was wound up in a roll shape, and did not change in color tone without yellowing after forced deterioration at 100 ° C. for 3 days. The results are shown in Table 1.

[Example 4]
In Example 1, a pressure-sensitive adhesive tape was produced in the same manner as in Example 1 except that the blending ratio of the hydrogenated aromatic modified terpene resin was changed from 10 parts by weight to 15 parts by weight. The adhesive tape thus obtained had good adhesiveness to the skin. The self-back surface adhesive strength of this adhesive tape was 1.10 N / 25 mm. In the practical test of the pressure-sensitive adhesive tape, no lifting or peeling of the overlapped portion was observed. This pressure-sensitive adhesive tape was wound up in a roll shape, and did not change in color tone without yellowing after forced deterioration at 100 ° C. for 3 days. The results are shown in Table 1.

[Comparative Example 1]
In Example 1, in place of 15 parts by weight of the acrylic oligomer, 10 parts by weight of isopropyl myristate, and in place of 10 parts by weight of the hydrogenated aromatic modified terpene resin, a terpene phenol resin (trade name “YS Polystar S145” manufactured by Yashara Chemical Co., Ltd.) ) An adhesive tape was prepared in the same manner as in Example 1 except that 20 parts by weight was used. The adhesive tape thus obtained had good adhesiveness to the skin. The self-back surface adhesive strength of this adhesive tape was 0.55 N / 25 mm. In the practical test of the pressure-sensitive adhesive tape, floating was observed at the edge portion of the overlapped portion. This pressure-sensitive adhesive tape was wound up in a roll and was slightly yellowish after forced deterioration at 100 ° C. for 3 days. The results are shown in Table 1.

(footnote)
(1) Acrylic copolymer (isononyl acrylate / 2-methoxyethyl acrylate / acrylic acid = 68/30/2% by weight; weight average molecular weight = about 550,000)
(2) Product name “JDX-P1020” manufactured by Johnson Polymer Co., Ltd., number average molecular weight = 1,500, Tg = −66 ° C., viscosity at 25 ° C. = 400 mPa · s
(3) Product name “CLEARON K-4090” manufactured by Yasuhara Chemical Co., Ltd.
(4) Product name “YS Polystar S145” manufactured by Yasuhara Chemical Co., Ltd.
(5) Trade name “Tetrad X” manufactured by Mitsubishi Gas Chemical Company, Inc.

  The adhesive tape for medical assistance of the present invention can be used as medical assistance such as fixation of gauze, bandage, catheter, infusion tube, blood transfusion tube, etc., wound treatment and protection, hemostasis, and operation site covering. .

FIG. 1 is an explanatory diagram relating to a practical test of an adhesive tape.

Explanation of symbols

1 Test piece in which two adhesive tapes are partially overlapped 2 Artificial kidney blood circuit 11 Adhesive tape 12 Adhesive tape 13 Overlap portion 14 End of overlap portion

Claims (6)

On one side of a support comprising a polyolefin-based nonwoven fabric, (a) an acrylic adhesive, (b) acrylic oligomer, (c) a rosin resins, terpene resins, _{C 5} petroleum resins, _{C 9} petroleum resins, phenol A medical aid in which a pressure-sensitive adhesive layer containing a resin, a rosin-modified phenol resin, a xylene resin, an alicyclic hydrogenated petroleum resin, or a coumarone-indene resin , and (d) a crosslinking agent is formed. An adhesive tape ,
(I) The pressure-sensitive adhesive layer contains 7 to 25 parts by weight of an acrylic oligomer, 7 to 25 parts by weight of a tackifier resin, and 0.01 to 3 parts by weight of a crosslinking agent with respect to 100 parts by weight of the acrylic pressure-sensitive adhesive. A layer formed from a pressure-sensitive adhesive composition, and
(Ii) As a measurement method, the test atmosphere which is the medical auxiliary pressure-sensitive adhesive tape cut at a temperature of 23 ± 2 ° C. and a relative humidity of 65 ± 5% and a width of 25 mm, with the pressure-sensitive adhesive side facing down, Measured by a measurement method in which the back surface of the medical auxiliary pressure-sensitive adhesive tape is pressure-bonded with a roller, the play portion of the test piece is folded back 180 degrees, peeled off at a peeling speed of 300 mm / min, and peeled off 180 degrees. The adhesive tape for medical assistance whose self-back surface adhesive strength of the said adhesive tape for medical assistance was 0.70-1.35N / 25mm .   The medical auxiliary pressure-sensitive adhesive tape according to claim 1, wherein the polyolefin-based nonwoven fabric is a polypropylene-based nonwoven fabric.   The medical auxiliary pressure-sensitive adhesive tape according to claim 1, wherein the support made of the polyolefin-based nonwoven fabric is perforated on the back surface on which the pressure-sensitive adhesive composition layer is not formed. The medical auxiliary pressure-sensitive adhesive tape according to any one of claims 1 to 3 , wherein the acrylic pressure-sensitive adhesive is a copolymer of a monomer mixture containing an alkyl acrylate ester and an alkoxyalkyl acrylate ester. The medical auxiliary pressure-sensitive adhesive tape according to any one of claims 1 to 4 , wherein the acrylic oligomer is a low molecular weight acrylic polymer having a number average molecular weight in the range of 500 to 50,000. The medical auxiliary pressure-sensitive adhesive tape according to any one of claims 1 to 5 , wherein the tackifier resin is a hydrogenated product of an aromatic modified terpene resin.

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