JP4875870B2 - Powder supply apparatus, powder supply method, powder supply and filling apparatus, and powder supply and filling method - Google Patents

Description

  The present invention relates to a powder supply apparatus and a powder supply method for automatically supplying powder, and a powder supply used in the field of manufacturing powders in general, specifically, pharmaceuticals, agricultural chemicals, foods, chemicals and the like. The present invention relates to a powder supply and filling apparatus and a powder supply and filling method for automatically supplying and filling a body.

In the supply of powder to a powder container, for example, a vial, when a pharmaceutical product, particularly an injectable preparation, is supplied to the powder container, the drug is administered parenterally (for example, subcutaneously, intramuscularly, intravenously, etc.) to the human body. Therefore, the amount of filling is not only accurate, but also the entry of foreign matters is an indispensable condition that must be avoided.
In the case of filling a powder container with a drug as powder, a powder filling apparatus is generally used. In such a conventional powder filling apparatus, a stirring wing is provided in a powder hopper that stores powder, the powder is stirred, the compaction state of the powder is relaxed, and a certain amount of powder is powdered. The body container was filled.

In such a powder filling apparatus, it is necessary to supply a powder as a medicine to the powder hopper at regular intervals. When such powder supply is necessary, the bottle bag, which is a bag body that is manually supplied or contains a medicine and is narrow at one end and provided with a valve or a cock at one end thereof, is powdered by the powder filling device. It was hung on the top of the body hopper and supplied using the natural fall of the drug.
JP 59-115201 A

In the manufacture of pharmaceuticals, it is strictly required to prevent foreign substances from being mixed, and strict regulations have been established in the manufacturing process to prevent foreign substances from being mixed. For example, it is stipulated that a medicine is filled in a powder container such as a vial with a clean vertical flow laminar flow of class 100 or less formed in an aseptic space in manufacturing an injectable preparation. Here, the class 100 means that the number of suspended fine particles of 0.5 μm or more is 100 / CF (cubic feet) or less or 3530 / m ³ or less. As described above, in spite of the strict regulation of the medicine filling process, as a conventional powder supply method for the powder filling apparatus, the medicine placed in a container (a mug-type container) is manually added to the powder filling apparatus. A bottle bag in which a medicine is stored by hand is hung in a supply hopper or directly above a powder filling device and supplied to the supply hopper. As described above, a clean vertical flow laminar flow state is formed around the powder filling device in the aseptic space to prevent foreign matter from entering, but the powder to the powder filling device is In the body supply, as described above, a person approaches the powder filling apparatus and puts the medicine in a container held by hand, or the bottle bag is manually hung directly above the powder filling apparatus and the supply operation is performed. It was done. As a result, the air flow around the powder filling device is disturbed and foreign matter may be mixed into the powder hopper, which is a problematic powder supply method.
As another powder supply method, there is a method of supplying a powder by providing a chute with a damper and a supply hopper above the hopper of the powder filling device. However, when this powder supply method is used, there are problems that the number of component parts of the apparatus is large, cleaning and assembly of parts are complicated, and sterilization is difficult to guarantee. Further, in this powder supply method, a large space is required above the hopper, it is difficult to secure a one-way flow path above the hopper, and the powder adheres to each part between the flow paths. There is a problem that the remaining amount increases.

  In addition, when supplying a drug that is powder using a bottle bag, the powder stored in the bottle bag stagnates in a narrow valve, and not all the drug in the bottle bag is supplied to the powder hopper. Had a problem. In addition, since the drug attached to the valve or the like in the bottle bag cannot be scraped out, particularly in the case of an expensive drug, the manufacturing cost is greatly affected.

  Furthermore, in the conventional supply method, the storage amount of the medicine in the supply hopper of the powder filling device increases rapidly at the time of supply, or the storage amount differs greatly between the state immediately before supply and the state immediately after supply. As described above, when the amount of the medicine stored in the supply hopper (storage level) is not constant, the powder filling apparatus may vary greatly in the filling amount of the powder container, for example, each vial. It has been confirmed by experiments. This experiment was performed by the powder filling apparatus used in the embodiment described later. According to the inventor's experiment, it has been confirmed that if the amount of medicine stored in the supply hopper (storage level) is within a specific range, the filling amount into the vial is substantially constant (within a specified range). .

An object of the present invention is to provide a powder supply apparatus that can solve various problems in conventional powder supply and can reliably supply a desired amount of powder automatically with a simple configuration. Further, in the present invention, in order to keep the filling amount in each powder container in the powder filling device constant, the powder that can keep the medicine storage level in the supply hopper of the powder filling device constant at all times. An object is to provide a body supply device and a powder supply and filling device.
Furthermore, an object of the present invention is to provide a powder supply method and a powder supply and filling method that can reliably supply a desired amount of powder.

In order to solve the above problems, a powder supply apparatus according to the present invention includes:
A powder supply device for supplying a powder medicine to a powder filling device disposed in a sterile space,
Is used as a container for storing a drug, the powder supply tube having one end opening to the other end to have a inner surface shape of a cylinder as a closing surface,
Desorption mechanism provided at the outer end where the closed surface is formed in the powder supply cylinder ,
A supply cylinder driving unit that is mounted by the desorption mechanism, holds the powder supply cylinder in a cantilevered manner, and rotates the powder supply cylinder around the center axis of the cylinder;
An angle adjustment unit for adjusting the central axis of the powder supply cylinder to a predetermined angle with respect to a horizontal plane ;
A transport unit configured to be movable so as to insert the opening-side end portion of the powder supply cylinder into the aseptic space in which the powder filling device is disposed; and a control unit for controlling the supply cylinder drive unit; equipped with,
The powder supply cylinder is inserted into an insertion hole formed in a partition wall that partitions the sterile space, the opening is disposed in the sterile space where the powder filling device is disposed, and the central axis of the cylinder is The central axis has a predetermined angle with respect to a horizontal plane, and is arranged such that a generatrix that is a lowermost end on an inner peripheral surface from the closed surface to the opening of the cylinder faces downward from the closed surface toward the opening. Is rotated at a predetermined speed around the rotation center, and the medicine stored in the cylinder is supplied from the opening to the powder filling device in the aseptic space .

The powder supply method according to the present invention comprises:
A powder supply method for supplying a powder medicine to a powder filling device arranged in an aseptic space using a powder supply device,
Desorption provided on the outer end portion of the powder supply cylinder in which the closed surface is formed so that the powder supply cylinder having a cylindrical inner surface shape in which one end is open and the other end is a closed surface is cantilevered. A mounting step of mounting on a supply cylinder driving unit of the powder supply device via a mechanism ;
The powder supply cylinder is inserted into an insertion hole formed in a partition wall that conveys the powder supply apparatus to a predetermined position and partitions a sterile space in which the powder filling apparatus is disposed, and the powder supply cylinder A conveying step of arranging the opening in the aseptic space in which the powder filling device is arranged,
The powder supply cylinder is rotated so that the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and the bus bar on the lowermost side on the inner peripheral surface from the closing surface of the cylinder to the opening is closed. An arrangement step of arranging the powder supply tube so as to face downward toward the opening; and rotating the powder supply tube at a predetermined speed around the central axis of the powder supply tube into the powder supply tube A supply step of supplying the stored medicine from the opening to the powder filling device in the sterile space ;
Have

The powder supply and filling device according to the present invention comprises:
A powder filling apparatus for filling a powder drug disposed in the powder container to the first sterile space, powder supply filling comprising a supplying powder feeder the agent to the powder filling apparatus A device,
The powder supply device is disposed in a second aseptic space partitioned from the first aseptic space by a partition wall.
Used as a container for storing medicine, has an inner cylindrical shape with one end opened and the other end closed, and is formed in the partition wall so that the opening is disposed in the first sterile space When inserted into the insertion hole, the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and the bus bar serving as the lowest end of the inner peripheral surface from the closing surface of the cylinder to the opening is the blocking surface are arranged so as to be downward toward the opening from the said central axis as the center of rotation, the drug housed in said powder feed cylinder by rotating said powder supply tube at a predetermined speed from the opening A powder supply cylinder configured to supply to a powder filling device;
Desorption mechanism provided at the outer end where the closed surface is formed in the powder supply cylinder ,
The powder supply cylinder is mounted by the desorption mechanism, the powder supply cylinder is cantilevered, and the center of the powder supply cylinder is inserted into the first aseptic space with the opening-side end of the powder supply cylinder inserted. A supply cylinder driving unit that rotationally drives the powder supply cylinder around an axis as a rotation center ;
An angle adjustment unit for adjusting the central axis of the powder supply cylinder to a predetermined angle with respect to a horizontal plane ;
A conveyance unit configured to be movable for inserting the opening side end of the powder supply cylinder into the first aseptic space, and a control unit for controlling the supply cylinder driving unit ,
The powder filling device includes:
A powder hopper in which the medicine in the powder supply cylinder is supplied from the opening;
A level sensor that detects a storage level in the powder hopper and outputs a command based on the detection to the control unit;
A filling mechanism for filling a predetermined amount of the drug in the powder hopper into the powder container at the filling position; and a transport mechanism for sequentially transporting the powder container to the filling position.

The powder supply and filling method according to the present invention includes:
A powder filling method using a powder filling apparatus for filling a powder container with a powder medicine in a first aseptic space, and a second aseptic space partitioned from the first aseptic space by a partition wall A powder supply and filling method comprising: a powder supply method for supplying the drug to the powder filling device by means of a powder supply device disposed therein,
The closed surface is formed in the powder supply cylinder so that the powder supply cylinder is used as a container for storing a medicine and has a cylindrical inner surface shape in which one end is open and the other end is a closed surface. A mounting step of mounting on a supply cylinder driving unit of the powder supply device via a desorption mechanism provided on the outer end portion ,
The powder supply device is transported to a predetermined position, the powder supply tube is inserted into an insertion hole formed in the partition wall, and the opening in the powder supply tube is in the first aseptic space. Conveying process to be arranged ,
The control unit rotates the powder supply cylinder so that the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and becomes the lowest end side on the inner peripheral surface from the closed surface of the cylinder to the opening. An arrangement step in which a bus is arranged downward from the closed surface toward the opening;
With the central axis of the powder supply cylinder as the center of rotation, the powder supply cylinder is rotated at a predetermined speed, and the medicine stored in the powder supply cylinder is transferred from the opening into the first aseptic space. Supply process to supply to the powder hopper of the powder filling device ,
A level sensor provided in the powder hopper detects a powder storage level in the powder hopper, and outputs a command based on the detection to the control unit, and sequentially transfers the powder containers to the filling position. And a filling step of filling a predetermined amount of the powder in the powder hopper into the powder container at the filling position.

According to the powder supply apparatus and the powder supply method according to the present invention, the powder supply cylinder having a simple configuration is rotated at a predetermined angle so that the powder in the powder supply cylinder is supplied to the powder supply region. Can be reliably fed into. In addition, according to the present invention, a container used for transportation and storage can be used as it is as a powder supply container, the powder supply container can be easily attached and assembled, and cleaning and sterilization are easy. It has an excellent effect of becoming.
According to the powder supply and filling apparatus and the powder supply and filling method of the present invention, the powder storage level in the powder hopper of the powder filling apparatus is always kept constant by using the powder supply apparatus having a simple configuration. And the filling amount of each powder container can be made constant.
According to the powder supply and filling apparatus and the powder supply and filling method according to the present invention, the powder can be automatically supplied to the supply hopper without a person approaching the supply hopper of the powder filling apparatus. The laminar flow of the vertical flow is not disturbed, and foreign substances can be prevented from being mixed into the sterile preparation.

According to the powder supply and filling apparatus and the powder supply and filling method according to the present invention, all of the powder to be supplied to the powder hopper of the powder filling apparatus is automatically and reliably supplied at a desired supply rate. Highly efficient powder supply becomes possible.
According to the powder supply and filling apparatus and the powder supply and filling method according to the present invention, the storage level of the powder in the supply hopper, for example, the medicine can be within a specific range, and the powder container, for example, the vial It becomes possible to reliably fill a certain amount of medicine.

  Preferred embodiments of a powder supply apparatus and a powder supply and filling apparatus according to the present invention will be described with reference to the accompanying drawings. Note that the powder supply and filling device includes a powder filling device that fills a powder container with powder and a powder supply device that supplies powder to the powder filling device.

  FIG. 1 is a side view showing a configuration of a powder supply and filling apparatus according to a preferred embodiment of the present invention. In FIG. 1, in order to facilitate the explanation of the powder supply and filling apparatus of the present embodiment, the shape, size, and interval of each component are different from the actual apparatus. In the powder supply and filling apparatus of the present embodiment, the powder supply apparatus 1 supplies powder to the powder filling apparatus 19 and the powder filling apparatus 19 fills the powder container 25 with powder. In the present embodiment, the powder container 25 is a vial, and the powder is a powdery medicine.

  As shown in FIG. 1, in the powder supply and filling apparatus of the present embodiment, a powder filling apparatus 19 is disposed in a filling booth 30 that is a first aseptic space, and a supply that is a second aseptic space. The powder supply device 1 is arranged in the area 31. The powder supply apparatus 1 is configured to be movable, and is arranged in the second aseptic space as shown in FIG. 1 during powder supply. Therefore, the powder supply and filling apparatus of the present embodiment is in a state of being disposed across two aseptic spaces when supplying powder.

  In each aseptic space of the filling booth 30 and the supply area 31, laminar flows (filling booth laminar flow 26, supply area laminar flow 27) are set from the upper side to the lower side to prevent contamination of dust and the like. Yes.

  In the filling booth 30 in which the powder filling device 19 is provided, vials 25 of powder containers to be filled are sequentially conveyed by a conveyance conveyor 32, and each vial 25 is filled at a filling position by a container position control plate 24. It is securely held. The partition wall 29 that partitions the supply area 31 where the powder supply device 1 is arranged and the filling booth 30 is formed with an insertion hole 34 penetrating therethrough, and the powder of the powder supply device 1 is formed in the insertion hole 34. A powder supply cylinder 10 serving as a supply portion is inserted. The powder supply cylinder 10 stores a drug that is a powder to be filled, and the drug is supplied from the powder supply cylinder 10 to the powder hopper 16 of the powder filling device 19.

[Powder filling device 19]
First, the configuration of the powder filling device 19 to which the medicine is supplied by the powder supply device 1 in the powder supply and filling device of the present embodiment will be described.
In FIG. 1, a powder filling device 19 that fills a plurality of vials 25 that are sequentially transported by a transport conveyor 32 with a medicine that is a powder is disposed above the vials 25 at a filling position. . The vial bottle 25 conveyed by the conveyance conveyor 32 is reliably arranged at a filling position below the filling drum 18 described later by the container position control plate 24. The powder filling device 19 includes a powder hopper 16, a powder supply unit 17, a filling drum 18 and the like from the top. The chemical supplied to the powder hopper 16 is supplied to each cylinder 18a of the filling drum 18 through the horizontal impeller 21 which is a stirring blade and the vertical impeller 22 of the powder supply unit 17, and is sequentially sucked and held. The cylinders 18 a are formed radially at equal intervals inside the filling drum 18, and opening portions connected to the cylinders 18 a are formed on the circumference of the filling drum 18. In the present embodiment, eight cylinders 18 a are formed radially at equal intervals inside the filling drum 18. A shaft body with a filter (not shown) attached to the tip is provided on the back side of each cylinder 18a (center side of the filling drum 18). The shaft body is configured to be movable in the axial direction within the cylinder 18a, and the powder holding amount of the cylinder 18a can be adjusted by moving the filter position. The filter used here is a PET filter (polyethylene terephthalate filter) that does not allow the powder to be retained to pass through the air.

  The filling drum 18 rotates by performing an intermittent operation, and the medicine transferred by the vertical impeller 22 of the powder supply unit 17 is supplied to the cylinder 18a at the top position. When the top cylinder 18a to which the medicine is supplied rotates, the medicine on the surface of the opening portion of the cylinder 18a is worn by the doctor blade 23 provided close to (not in contact with) the vicinity of the top of the filling drum 18. Thus, a predetermined amount of medicine is reliably held in the cylinder 18a. The top cylinder 18a of the filling drum 18 is evacuated from the back side, and the supplied medicine is sucked and held. In a state where the medicine is sucked and held, the cylinder 18a is moved (rotated counterclockwise in FIG. 1) by the intermittent operation of the filling drum 18 and reaches the filling position which is the position of the lower end portion of the filling drum 18. . Compressed air is blown from the back side of the cylinder 18a that has reached this filling position, and the held medicine is discharged directly below to fill the vial bottle 25 at the filling position. Compressed air for cleaning the cylinder including the filter is blown onto the cylinder 18a after the medicine is discharged. Then, the filling drum 18 rotates, and the medicine is supplied again by the powder supply unit 17 to the cylinder 18a that has reached the top.

As described above, the medicine supplied from the powder supply device 1 is received by the powder hopper 16, and each of the filling drums 18 is provided via the horizontal impeller 21 of the powder hopper 16 and the vertical impeller 22 of the powder supply unit 17. The filling operation is performed on the vial 25 which is supplied to the cylinder 18a and is a powder container at the filling position. Thus, although the filling amount with which the vial bottle 25 is filled depends on the holding amount of each cylinder 18a, the holding amount of each cylinder 18a corresponds to the storage level of the medicine stored in the powder hopper 16 at that time. It has been confirmed by the inventors' experiment that it is greatly influenced. In the powder filling device 19 of the present embodiment, the powder hopper 16 is provided with a level sensor 20 for detecting the storage level. The level sensor 20 used in the present embodiment is a capacitance level sensor. The electrostatic capacity level sensor utilizes a change in electrostatic capacity when an electrode as a detection unit is buried in a medicine as an object to be measured.
A signal from a level sensor 20 provided for detecting the medicine storage level of the powder hopper 16 is input to the powder supply device 1 as described later, and the rotational operation of the powder supply cylinder 10 is controlled. Yes.

[Powder supply device 1]
The powder supply apparatus in the powder supply and filling apparatus of the present embodiment supplies the drug to the powder hopper 16 of the powder filling apparatus 19 configured as described above, and the powder supplied with the drug The body filling device 19 reliably fills each vial 25 with a predetermined amount of medicine. The powder supply device according to the present embodiment controls the amount of supplied medicine so that the medicine storage level in the powder hopper 16 becomes substantially constant when the medicine is supplied to the powder hopper 16 of the powder filling device 19. ing. As described above, the powder hopper 16 is provided with the level sensor 20 and outputs a detection signal when the medicine stored in the powder hopper 16 becomes lower than a predetermined level set in advance. The level sensor 20 may be configured to detect whether or not the drug in the powder hopper 16 is lower than a predetermined level. In addition to the configuration that outputs a detection signal when the drug is lower than the predetermined level, the level sensor 20 On the contrary, it is possible to cope with a configuration in which the signal is cut off when it becomes lower than the predetermined level.

Hereinafter, the configuration of the powder supply apparatus 1 of the present embodiment will be described in detail.
As shown in FIG. 1, the powder supply apparatus 1 according to the present embodiment is provided with a powder supply cylinder 10 that stores a predetermined amount of drug and supplies the drug to the powder hopper 16 of the powder filling apparatus 19. It has been. Further, the powder supply apparatus 1 of the present embodiment includes a supply cylinder driving unit 2 that rotationally drives the powder supply cylinder 10 around its central axis, and the central axis of the powder supply cylinder 10 from the vertical direction to the horizontal direction. An angle adjustment unit 3 that can be rotated to a position where it becomes, a lifting unit 4 that moves the powder supply tube 10 up and down, a transport unit 5 that transports the powder supply tube 10, a drive of the powder supply tube 10, etc. And a control unit 6 that performs control.

The inner surface of the powder supply cylinder 10 is formed in a cylindrical shape with a bottom. One end of the powder supply cylinder 10 has an opening 10a to serve as a supply port for the stored medicine. A coupling mechanism 8 is provided at the other end of the powder supply cylinder 10, and the coupling mechanism 8 is configured to be detachable from the rotary shaft body of the supply cylinder driving unit 2.
FIG. 2 is a side view showing the powder supply cylinder 10. As shown in FIG. 2, a positioning pin 10d and two twist lock projections 10b are provided at the center of the bottom of the powder supply cylinder 10. The positioning pin 10d is fitted into a bottomed hole formed in the coupling mechanism 8, and the twist lock projection 10b is inserted into an engagement hole formed in the coupling mechanism 8 to be engaged by twisting, and powder. The body supply cylinder 10 and the coupling mechanism 8 are configured to be securely fixed at predetermined positions. Further, two handles 10c, 10c are provided in the vicinity of the bottom portion on the side surface of the powder supply cylinder 10 at positions facing each other. The handle 10c is a handle that is used when the powder supply cylinder 10 is twisted and removed from the coupling mechanism 8 and when the powder supply cylinder 10 is carried.
The powder supply cylinder 10 is detachable, and the powder supply cylinder 10 itself can be easily sterilized. Therefore, when supplying an injectable preparation that requires assurance of sterility, first, the powder supply cylinder 10 is first sterilized, and the injection preparation is accommodated in the powder supply cylinder 10 to perform the supply operation. It can be configured.

  In the present embodiment, the opposing portion of the side surface (inner side surface) on the inner surface of the powder supply cylinder 10 is configured in parallel with the central axis, and the connection region between the inner side surface and the bottom surface that is the closed surface is a curved surface. It is configured. For this reason, the inner surface for storing the drug in the powder supply cylinder 10 is all formed in a curved surface, and the stored drug moves without stagnation with the inner surface as the powder supply cylinder 10 moves. The inner surface of the powder supply cylinder 10 of the present embodiment is formed into a smooth surface by electrolytic polishing. The powder supply cylinder 10 used in the powder supply apparatus 1 of the present embodiment has an inner diameter of 240 mm and a length of 800 mm, and is made of stainless steel SUS316L.

A supply cylinder driving unit 2 provided on the opposite side of the coupling mechanism 8 to which the powder supply cylinder 10 is attached includes a gear motor 9 and a bearing that rotate the powder supply cylinder 10 at a predetermined rotation speed (for example, 1 rpm). Is provided. The powder supply cylinder 10 is attached to the supply cylinder drive unit 2 via a coupling mechanism 8, and the angle adjustment unit 3 rotates the powder supply cylinder 10 from the vertical direction to the horizontal direction. It is configured to be movable. In this rotation operation, the powder supply cylinder 10 and the supply cylinder drive unit 2 rotate integrally. The angle adjustment unit 3 includes a speed reducer, an angle adjustment mechanism, and a manual handle.
In the present embodiment, the position of the center of gravity of the supply cylinder drive unit 2 is arranged on the rotation center axis of the powder supply cylinder 10, and the drive shaft for angle adjustment by the angle adjustment unit 3 is the supply cylinder drive unit. 2 and the powder supply cylinder 10. In the present embodiment, a drive shaft for angle adjustment is connected in the vicinity of the position of the center of gravity of the rotating body constituted by the powder supply cylinder 10 and the supply cylinder drive unit 2.

  The powder supply cylinder 10, the supply cylinder drive unit 2, and the angle adjustment unit 3 are provided on the support arm 7 of the elevating unit 4, and can be moved to a desired height by the raising and lowering operations of the support arm 7. It is configured as follows. The elevating unit 4 includes an elevating cylinder 33 extending in the vertical direction and a support arm 7 that moves along the elevating cylinder 33. The elevating cylinder 33 is provided with an upper limit switch that defines the upper limit position of the support arm 7 and a lower limit switch that defines the lower limit position. In this embodiment, an overrun switch is provided as an auxiliary switch for the upper limit switch. The lowering operation in the elevating unit 4 is lowered by the weight of the elevating unit 4 by removing the oil in the hydraulic cylinder as a lowering valve “open”.

  Moreover, the powder supply apparatus 1 of this Embodiment is provided with the conveyance part 5 to which the raising / lowering part 4 and the control part 6 were fixed. The transport unit 5 is provided with wheels (front wheels 13 and rear wheels 14) on the front and rear sides thereof, and is configured to be movable only in one direction in the front-rear direction. A guide rail 11 and a stopper 12 are provided on the floor surface of the supply area 31 so that the powder supply device 1 arranged in the supply area 31 is securely arranged at a predetermined position. The supply area 31 is provided with a positioning sensor (not shown) constituted by a contact switch. When the powder supply device 1 is disposed at a predetermined supply position in the supply area 31, the positioning sensor contacts and outputs a position signal to the control unit 6. The controller 6 is configured to start the powder supply operation only when a position signal from the positioning sensor is input.

In the powder supply device 1 of the present embodiment, the operator holds the handle 35 provided on the upper portion of the control unit 6 and moves the entire powder supply device 1 back and forth. It goes without saying that an electric motor or the like may be used as a drive source for moving the powder supply apparatus 1.
Further, the control unit 6 changes the rotation speed of the powder supply cylinder 10 by the supply cylinder driving unit 2 and supplies the powder by the angle adjustment unit 3 according to the type and characteristics of the medicine that is the powder to be supplied. You may comprise so that the center axis | shaft of the pipe | tube 10 can be adjusted to a desired angle with respect to a horizontal surface. In this case, the angle adjustment unit 3 performs angle adjustment by electric drive.

[Powder supply and filling operation]
Next, the powder supply and filling operation by the powder supply and filling apparatus in which the powder supply apparatus 1 and the powder filling apparatus 19 configured as described above are arranged at a predetermined position and configured integrally will be described. As shown in FIG. 1, when the powder supply device 1 of the present embodiment is disposed at a predetermined position in the supply area 31, the powder supply cylinder 10 is a partition wall 29 that partitions the filling booth 30 and the supply area 31. The central axis of the powder supply cylinder 10 has an inclination of about +5 degrees (downward angle indicated by symbol A in FIG. 1) with respect to the horizontal plane, and the opening 10a is disposed downward. ing. In this state, the powder supply cylinder 10 rotates around its central axis (for example, 1 rpm), the medicine inside the powder supply cylinder 10 gradually falls, and the powder hopper 16 of the powder filling device 19 To be supplied. At this time, the electrode which is the detection part of the level sensor 20 attached to the powder hopper 16 is arranged so that the falling medicine does not fall.

When the medicine is supplied to a preset storage level in the powder hopper 16, the level sensor 20 outputs a detection signal to the control unit 6. Stopping the rotation of the powder supply cylinder 10 is controlled by a delay timer (delay timer). This delay timer can be controlled from 0 seconds to 600 seconds. For example, when set at 0 seconds, the control unit 6 to which the detection signal is inputted stops the rotation of the powder supply cylinder 10 instantaneously, The medicine supply operation by the powder supply cylinder 10 is stopped. Thereafter, when the level sensor 20 stops outputting the detection signal, the powder supply cylinder 10 is started to rotate to supply the medicine again. Furthermore, when the detection signal is output, the rotation of the powder supply cylinder 10 is stopped. As described above, based on the detection signal from the level sensor 20, the powder supply cylinder 10 of the powder supply and filling apparatus 1 is driven to supply a desired amount of medicine to the powder hopper 16 of the powder filling apparatus 19. Thus, the powder hopper 16 is always in a state where a certain level of medicine is stored.
In a state where a certain level of medicine is stored in the powder hopper 16 as described above, stirring is performed by the rotation of the horizontal impeller 21 of the powder hopper 16 to prevent aggregation, and the medicine is introduced into the powder supply unit 17. The cylinders 18 a of the filling drum 18 are sequentially filled by the rotation of the vertical impeller 22.

  FIG. 3 is a graph showing the experimental results of the powder supply and filling operation as described above. In FIG. 3, the vertical axis represents the filling amount average value [mg] of each vial and the storage amount (estimated value) [g] of the powder hopper 16, and the horizontal axis represents the filling time [minutes]. The filling amount average value is an average value of the medicine filling amounts in the three vial bottles that are extracted by three each of the vial bottles filled by the cylinders 18a of the filling drum 18 and filled by the respective cylinders 18a. In FIG. 3, the value indicated by the mark ■ in the upper part of the graph indicates the amount stored in the powder hopper 16. The line graph in the middle of the graph of FIG. 3 is the filling amount average value. Since the number of cylinders 18a of the filling drum 18 used in the experiment shown in FIG. 3 is eight, eight line graphs relating to the drug filling amount in the vial filled with each of the eight cylinders 18a are described. ing. As shown in FIG. 3, the storage amount of the powder hopper 16 is substantially constant in the vicinity of about 3400 g, and the amount of the medicine filled in each vial is within a desired range, that is, the target value over time. On the other hand, it was within the range of ± 2.5%.

In the powder supply device according to the present embodiment, an example in which the opposing portions on the inner side surface of the powder supply cylinder 10 are configured in parallel with each other will be described. However, the present invention is limited to such a configuration. For example, a cylindrical shape in which the side surface on the inner surface of the powder supply cylinder 10 is inclined with respect to the central axis so that the opening 10a of the powder supply cylinder 10 is wider than the bottom surface. But you can. In the present invention, the cylinder includes not only a shape in which opposing portions on the inner side face are configured in parallel, but also those in which the opposing portions on the inner side face are skewed. When the supply operation is performed by the cylindrical powder supply cylinder 10 configured in this way, the bus bar located on the lowermost end side on the inner peripheral surface of the powder supply cylinder 10 is arranged so as to face downward toward the opening, The medicine in the powder supply cylinder 10 is rotated at a predetermined speed around the central axis of the powder supply cylinder 10 to supply the medicine in the powder supply cylinder 10 from the opening 10a to the powder hopper 16a. Even in such a configuration, it is preferable that the connection region between the inner side surface and the bottom surface of the powder supply tube 10 is a curved surface.
Further, in the present embodiment, the powder supply cylinder 10 is made of SUS316L, and the inner surface finish is described by an example in which electrolytic polishing is performed after buffing, but other commonly used metal polishing is used. It is applicable even if

In the powder supply operation by the powder supply apparatus of the present embodiment, the powder supply cylinder 10 has a central axis with respect to a horizontal plane or a bus bar on the lowermost side on the inner peripheral surface of the powder supply cylinder 10 is about +5. Although the case where it is arranged downward with an inclination of degrees has been described, according to the inventor's experiment, the angle is preferably changed depending on the target powder, for example, in the range of +1 to +10 degrees A preferable result can be obtained according to the characteristics of the powder if it is arranged at an angle within the range. However, favorable results were obtained for various drugs even when the powder supply cylinder 10 was fixed at an angle of +5 degrees.
In addition, the rotational movement around the central axis of the powder supply cylinder 10 should be changed in the target powder. The rotational speed is preferably between 0.1 rpm and 10 rpm, particularly preferably 1 rpm. It is between 3 rpm and above. However, when the rotational speed exceeded 10 rpm, dust scattering was not preferable. In addition, when the speed was lower than 0.1 rpm, the powder was not supplied smoothly, and it took a long time to supply the powder, and the preferable supply operation was not achieved. The powder supply time from the powder supply cylinder 10 depends on the inner diameter, length and powder characteristics of the powder supply cylinder 10.

[Conveying operation of powder supply apparatus 1]
In the supply operation by the powder supply apparatus 1 arranged in the supply area 31 of the second aseptic space as described above, the powder supply cylinder 10 stores only a medicine that is a fixed amount (for example, 5 kg) of powder. Therefore, the supply operation by the powder supply cylinder 10 needs to be replaced with another powder supply cylinder 10 containing the medicine after a certain time (for example, 20 minutes) has elapsed. Therefore, after the powder supply cylinder 10 that has finished the supply operation is moved so that the central axis thereof is horizontal, the powder supply cylinder 10 is pulled out from the insertion hole 34 of the partition wall 29. At this time, the powder supply apparatus 1 moves the wheels 13 and 14 along the guide rail 11 to a predetermined replacement position. In this exchange position, the powder supply cylinder 10 is rotated to a position where its central axis is in the vertical direction, and is removed from the coupling mechanism 8. As shown in FIG. 2, the two twist lock protrusions 10 b formed on the bottom of the powder supply cylinder 10 are removed from the engagement holes of the coupling mechanism 8 by holding and twisting the handle 10 c.

  FIG. 4 is a side view showing the powder supply cylinder 10 in which a new medicine is stored, and shows a state where the lid 36 is attached. As shown in FIG. 4, the lid 36 is fixed to the powder supply cylinder 10 by elastic string-like fixing bands 37 provided with hooks 37 a, 37 a at both ends. In the powder supply apparatus 1 of the present embodiment, the lid 36 is formed of PTFE (polytetrafluoroethylene resin). Hooks 37 a and 37 a at both ends of the fixed band 37 are hooked on the handle 10 c of the powder supply cylinder 10, and the lid 36 is pressed against and fixed to the powder supply cylinder 10.

  FIG. 5 is a side view showing a state in which the powder supply cylinder 10 containing the medicine is mounted on the powder supply apparatus 1. As shown in FIG. 5, the powder supply cylinder 10 is held by the powder supply apparatus 1 so that the central axis thereof is in the vertical direction. From this state, the powder supply cylinder 10 is moved with respect to the horizontal direction. -2.5 degrees (upward angle indicated by B in FIG. 6), that is, the opening 10a of the powder supply cylinder 10 is rotated slightly upward. 6 is a side view showing a state where the powder supply cylinder 10 is at a position having an angle of −2.5 degrees with respect to the horizontal direction, and FIG. 7 is a plan view showing the state of FIG.

  In the state shown in FIG. 6 and FIG. 7, the lifting unit 4 is lifted to lift the support arm 7 and place the powder supply cylinder 10 at a predetermined height. As described above, the powder supply cylinder 10 is lifted to a predetermined height, and the powder supply apparatus 1 is moved along the guide rail 11 to a predetermined position. When the powder supply device 1 reaches a predetermined position (supply position) in the supply area 31 which is the second aseptic space, the stopper 12 provided at the end of the guide rail 11 comes into contact with the front wheel 13 and the limit sensor ( (Not shown) is turned on, and a supply operation is possible. At this time, the powder supply apparatus 1 is securely fixed to the supply position by a fixing means such as inserting a fixing pin into the transport unit 5.

  When the powder supply apparatus 1 is in the supply position of the supply area 31 as described above, the powder supply cylinder 10 is inside the insertion hole 34 of the partition wall 29 that is a partition with the filling booth 30 that is the first aseptic space. Has been inserted. An opening 10 a that is the tip of the powder supply cylinder 10 inserted into the insertion hole 34 of the partition wall 29 is disposed above the powder hopper 16 of the powder filling device 19. The lid 36 is removed just before the powder supply cylinder 10 is inserted into the insertion hole 34 of the partition wall 29.

Thus, in the state where the opening 10a of the powder supply cylinder 10 is disposed above the powder hopper 16 of the powder filling device 19, the angle adjustment handle 38 of the rotation adjusting unit 3 is rotated to supply the powder. The central axis of the cylinder 10 is inclined at an angle of +5 degrees with respect to the horizontal direction. That is, it arrange | positions so that the opening 10a of the powder supply cylinder 10 may face downward. The powder supply cylinder 10 at this time is arranged at a position where the medicine supplied from the opening 10a does not fall on the detection unit of the level sensor 20.
As described above, when the powder supply device 1 is disposed at the supply position of the supply area 31 that is the second aseptic space and the central axis of the powder supply cylinder 10 is inclined at an angle of +5 degrees with respect to the horizontal direction. The powder supply apparatus 1 is in a state where a supply operation is possible. In this state, when the operator commands the control unit 6 to start the supply operation, the supply tube driving unit 2 is activated and the powder supply tube 10 starts rotating. As a result, the medicine gradually moves toward the opening 10 a on the inner surface of the powder supply cylinder 10 and falls into the powder hopper 16 from the opening 10 a. When the medicine is supplied to a predetermined storage level inside the powder hopper 16, the level sensor 20 outputs a detection signal, and the rotation operation of the powder supply cylinder 10 by the supply cylinder drive unit 2 is stopped. Thereafter, supply and stop are repeated based on the detection signal from the level sensor 20, and a predetermined level of medicine is always held in the powder hopper 16. Subsequent filling operation to the vial 25 which is a powder container by the powder filling device 19 is as described above.

In the powder supply apparatus of the present embodiment, as powder, drug A (particle size: 10.1 μm, specific surface area: 1.70 m ² / g, angle of repose: 69.5 °), drug B (particle size) 10.9 μm, specific surface area: 1.61 m ² / g, angle of repose: 54.3 °, drug C (particle size: 16.4 μm, specific surface area: 1.73 m ² / g, angle of repose: 58.1) ) And a drug D (particle size: 21.0 μm, specific surface area: 1.74 m ² / g, angle of repose: 57.0 °), and results of preferable results for all drugs was gotten. Furthermore, as a result of experiments conducted by the inventor, preferable results were obtained when the particle size of the powder to be supplied was 10 μm or more.

In the powder supply apparatus 1 of the present embodiment, the chemicals are sequentially supplied into the powder hopper 16 by the rotation operation of the powder supply cylinder 10, and all of the chemicals in the powder supply cylinder 10 are supplied. Supplied. This is because the inner surface of the powder supply cylinder 10 is entirely formed of a curved surface, and there is no obstacle to restrict the movement of the stored medicine inside.
In the powder supply apparatus 1 of the present embodiment, the powder supply cylinder 10 is vibrated and dropped so as to be able to cope with a case where a part of the medicine remains in the powder supply cylinder 10. An electromagnetic knocker 15 (see FIG. 7) is provided as an auxiliary. This electromagnetic knocker 15 converts electromagnetic force into vibration, and is configured to apply a slight vibration to the powder supply cylinder 10 to move the medicine inside the powder supply cylinder 10 toward the opening 10a and drop it. ing.

  In the powder supply device of the present embodiment, a cover is provided on the sliding portion that rotates at high speed, for example, the supply cylinder driving unit 2 having a gear motor 9 and a bearing, the angle adjusting unit 3 having a speed reducer, etc. Is completely prevented.

[Transfer to the powder supply cylinder 10]
As described above, the powder supply cylinder 10 containing the medicine is mounted on the powder supply apparatus 1 and is transported to the supply area 31 which is the second aseptic space, and the supply operation is performed. A transfer operation for transferring the sterile preparation from a square bag, which is a square resin bag body in which a medicine to be filled, such as a sterile preparation, is hermetically sealed and stored in the powder supply cylinder 10 will be described below.
The transfer operation for transferring the drug from the square bag to the powder supply cylinder 10 is performed in the transfer booth 28 which is the third aseptic space. The transfer booth 28 is in a sterile state of the same grade as the filling booth which is the first aseptic space described above, and is a space where an operator cannot enter and exit. Therefore, the work inside the transfer booth is performed by an operator outside the transfer booth inserting his hands through the two openings provided on the walls constituting the transfer booth 28. The sterilization condition is always maintained in the transfer booth. In addition, since the transfer booth 28 which is the third aseptic space is made of a wall material by a transparent member, the state inside the transfer booth can be visually confirmed from the external space.
For example, a predetermined amount (for example, 5 kg) of a drug that is a sterile preparation is stored in a sealed state in a square bag that is a resin bag. The square bag is opened in the transfer booth, and the drug transfer operation is performed on the sterilized powder supply cylinder 10.

FIG. 8 is an explanatory view showing the transfer work performed in the transfer booth, and transfer is performed by the work from (a) to (e).
As shown in FIG. 8A, first, the square bag 39 is opened in the transfer booth and placed on the fixed table 40 b of the storage table 40. The storage stand 40 in the transfer booth is formed in a lattice shape and has a plurality of openings in order to secure a one-way flow. The storage table 40 is divided into a swing table 40a and a fixed table 40b, and the swing table 40a is configured to rotate so as to hang down at one end of the fixed table 40b. The powder supply cylinder 10 is placed on the swing base 40a of the storage base 40, and the opened portion 39a of the opened square bag 39 is disposed so as to cover the outer peripheral surface of the opening 10a of the powder supply cylinder 10. . At this time, a part of the opening portion 39a is rounded so that the opening portion 39a of the square bag 39 is in close contact with the portion of the opening 10a of the powder supply cylinder 10.

The state shown in FIG. 8B is a state in which the open portion 39a of the square bag 39 is in close contact with the opening 10a of the powder supply cylinder 10 without a gap. At this time, the rounded portion of the square bag 39 is disposed on a part of the outer peripheral surface of the powder supply cylinder 10 (upper portion in FIG. 8B).
As shown in FIG. 8C, in the state where the outer peripheral surface of the opening 10a of the powder supply cylinder 10 and the opening portion 39a of the square bag 39 are in close contact with each other, the transfer ring 41 is attached to the close contact portion. FIG. 9A is a front view showing a transfer ring 41 used in the transfer operation shown in FIG. FIG. 9B is a cross-sectional view taken along line AA ′ of FIG. As shown in FIG. 9 (a), the transfer ring 41 is configured such that two arcuate bodies 41a and 41b are combined into an annular shape, and one of the arcuate bodies 41a and 41b to which the two arcuate bodies 41a and 41b are connected. A hinge 42 is provided at the connecting position so as to be able to bend each other, and a catch lock as a hooking means, that is, a so-called hooked patch lock 43 is provided at the other connecting position. The transfer ring 41 is rotatable around a hinge 42, and is configured such that a connecting portion provided with a hooked patchon lock 43 can be opened. A recess 41 c is formed on a part of the inner surface of the transfer ring 41. In a state where the transfer ring 41 is mounted in the opening 10a of the powder supply cylinder 10, the rounded portion of the square bag 39 is disposed in the recess 41c. In the present embodiment, the transfer ring 41 is formed by molding PTFE (poly 4 hooker ethylene resin).

As shown in FIG. 8D, the swing table 40a on which the powder supply cylinder 10 is placed in the storage table 40 hangs down from the fixed table 40b at a predetermined angle, and the powder supply cylinder 10 has an opening 10a. Will be in an upward state. In this state, the square bag 39 is lifted to drop all the medicines in the square bag 39 into the powder supply cylinder 10. At this time, the powder supply cylinder 10 is arranged so that the position of the recess 41c of the transfer ring 41 is on the upper side. In the present embodiment, the angle at which the swing base 40a as the powder supply cylinder holding base hangs down from the fixed base 40b as the back support base is about 60 degrees with respect to the horizontal plane, but from 40 degrees. If it is within the range of 70 degrees, it is possible to reliably transfer the medicine without scattering.
After the transfer is completed, as shown in FIG. 8E, the swing table 41a is returned to the horizontal position, and the transfer operation is completed by covering the opening 36a of the powder supply cylinder 10 with the lid 36 described above. At the end of the transfer operation, the fixing band 37 shown in FIG. 4 is attached to the powder supply cylinder 10, and the lid 36 is securely fixed to the opening 10 a of the powder supply cylinder 10.

As described above, by using the transfer ring 41 in the above transfer work, the transfer work is easy and reliable. As shown in FIG. 9B, the transfer ring 41 is formed with a flange portion 41 d, so that the opening portion that is the connection position of the square bag 39 is narrower than the opening 10 a of the powder supply tube 10. Become. As a result, in the transfer operation, the medicine in the square bag 39 can be smoothly and reliably stored in the powder supply cylinder 10 without stagnation in the opening 10 a of the powder supply cylinder 10.
As shown in FIG. 9B, a ring-shaped convex portion 10e is formed in the opening 10a of the powder supply cylinder 10, and a groove 41e is formed at a position corresponding to the convex portion 10e on the inner surface of the transfer ring 41. Is formed. Thereby, when the transfer ring 41 is attached to the powder supply cylinder through the opening portion of the square bag 39, the convex portion 10e formed in the opening 10a of the powder supply cylinder 10 is stored in the groove 41e, The transfer ring 41 is securely fitted into the opening 10 a of the powder supply cylinder 10.

As described above, in the transfer operation in the above embodiment, it is possible to reliably transfer all of the medicine in the square bag 39 to the powder supply cylinder 10. In addition, since the transfer operation is performed inside the transfer booth that is a sterile space, the safety of the sterile preparation is reliably ensured.
The filling booth 30 that is the first aseptic space and the transfer booth 28 that is the third aseptic space used in the above-described embodiment are made of wall materials using transparent members, and the second Since the supply area 31 which is the aseptic space is configured with a curtain using a transparent member, each room is configured to be visually confirmed from the external space.

According to the present invention, as described in detail in the above embodiment, it is possible to provide an apparatus capable of supplying and filling a medicine while ensuring absolute safety in pharmaceutical manufacturing. . The powder supply device of the present invention is capable of supplying a drug as a powder to the powder filling device while ensuring an aseptic and dust-free environmental state, and is an excellent and reliable device. Become.
In the present invention, the part for supplying the drug in the powder supply device is a powder supply cylinder configured in a simple cylindrical shape with nothing provided on the inner surface. There is no generation source, and the structure is easy to clean after use. In addition, it is easy to attach and detach the container that is the powder supply cylinder. Furthermore, the powder supply apparatus of the present invention has a very simple configuration and can be easily moved, so it is highly versatile and can produce and transport various powders, especially pharmaceuticals, agricultural chemicals, foods, chemicals, etc. It can be used as a supply device.
In the powder supply and filling apparatus of the present invention, the powder storage level in the powder hopper of the powder filling apparatus can be kept constant by using a powder supply apparatus having a simple configuration. It is a reliable device to maintain the filling amount of the container at a predetermined amount.

  The present invention is useful in the field of powder production of a powder supply mechanism for supplying powder, particularly in the fields of pharmaceuticals, agricultural chemicals, foods, chemicals and the like.

Explanatory drawing which shows the structure of the powder supply apparatus of this Embodiment which concerns on this invention Side view showing a powder supply cylinder in the powder supply apparatus of the present embodiment The graph which shows the experimental result which performed the powder supply and filling operation | movement using the powder supply apparatus of this Embodiment The side view which shows the state in which the chemical | medical agent which is a supply object was accommodated in the powder supply cylinder in the powder supply apparatus of this Embodiment. In the powder supply apparatus of this Embodiment, the side view which shows the state with which the powder supply cylinder in which the chemical | medical agent was accommodated was mounted | worn with the powder supply apparatus. In the powder supply apparatus of this Embodiment, the side view which shows the state which has a powder supply cylinder in the position which has a desired angle with respect to a horizontal direction. The top view which shows the powder supply apparatus shown in FIG. Explanatory drawing which shows the transfer work performed in a transfer booth in this Embodiment. Front view showing a transfer ring used in the transfer work in the present embodiment

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Powder supply apparatus 2 Supply cylinder drive part 3 Angle adjustment part 4 Lifting part 5 Conveyance part 6 Control part 7 Support arm 8 Coupling mechanism 9 Gear motor 10 Powder supply cylinder 11 Guide rail 12 Stopper 13 Wheel (front wheel)
14 wheels (rear wheels)
15 Electromagnetic knocker 16 Powder hopper 17 Powder supply unit 18 Filling drum 19 Powder filling device 20 Level sensor 21 Horizontal impeller 22 Vertical impeller 23 Doctor blade 24 Container position control plate 25 Vial bottle 26 Laminar flow (filling booth)
27 Laminar flow (supply area)
28 Transfer booth 29 Partition wall 30 Filling booth 31 Supply area 32 Conveyor 33 Lifting cylinder 34 Insertion hole 35 Handle 36 Lid 37 Fixed band 38 Angle adjustment handle 39 Square bag 40 Storage stand 41 Transfer ring 42 Hinge 43 Patchon lock

Claims (16)

A powder supply device for supplying a powder medicine to a powder filling device disposed in a sterile space,
Is used as a container for storing a drug, the powder supply tube having one end opening to the other end to have a inner surface shape of a cylinder as a closing surface,
Desorption mechanism provided at the outer end where the closed surface is formed in the powder supply cylinder ,
A supply cylinder driving unit that is mounted by the desorption mechanism, holds the powder supply cylinder in a cantilevered manner, and rotates the powder supply cylinder around the center axis of the cylinder;
An angle adjustment unit for adjusting the central axis of the powder supply cylinder to a predetermined angle with respect to a horizontal plane ;
A transport unit configured to be movable so as to insert the opening-side end portion of the powder supply cylinder into the aseptic space in which the powder filling device is disposed; and a control unit for controlling the supply cylinder drive unit; equipped with,
The powder supply cylinder is inserted into an insertion hole formed in a partition wall that partitions the sterile space, the opening is disposed in the sterile space where the powder filling device is disposed, and the central axis of the cylinder is The central axis has a predetermined angle with respect to a horizontal plane, and is arranged such that a generatrix that is a lowermost end on an inner peripheral surface from the closed surface to the opening of the cylinder faces downward from the closed surface toward the opening. A powder supply device configured to rotate at a predetermined speed around the rotation center and supply the medicine stored in the cylinder to the powder filling device in the aseptic space from the opening .   The powder supply apparatus according to claim 1, further comprising an elevating unit that holds the powder supply cylinder so as to be movable up and down.   The powder supply apparatus according to claim 1, wherein a portion of the inner surface of the powder supply cylinder facing the side surface is configured in parallel with the central axis, and a connection region between the side surface and the closed surface is configured by a curved surface. The powder supply apparatus according to claim 1, wherein the control unit is configured to control rotation of the powder supply cylinder in response to a command from the powder filling apparatus to which the powder is supplied. The powder supply apparatus according to claim 1, wherein the supply cylinder driving unit is configured to change a rotation speed of the powder supply cylinder according to a medicine to be supplied. The control unit changes the rotation speed of the powder supply cylinder by the supply cylinder driving unit according to the medicine to be supplied, and adjusts the central axis of the powder supply cylinder to a predetermined angle with respect to the horizontal plane by the angle adjustment unit. The powder supply apparatus according to claim 1 configured as described above. A powder supply method for supplying a powder medicine to a powder filling device arranged in an aseptic space using a powder supply device,
Desorption provided on the outer end portion of the powder supply cylinder in which the closed surface is formed so that the powder supply cylinder having a cylindrical inner surface shape in which one end is open and the other end is a closed surface is cantilevered. A mounting step of mounting on a supply cylinder driving unit of the powder supply device via a mechanism ;
The powder supply cylinder is inserted into an insertion hole formed in a partition wall that conveys the powder supply apparatus to a predetermined position and partitions a sterile space in which the powder filling apparatus is disposed, and the powder supply cylinder A conveying step of arranging the opening in the aseptic space in which the powder filling device is arranged,
The powder supply cylinder is rotated so that the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and the bus bar on the lowermost side on the inner peripheral surface from the closing surface of the cylinder to the opening is closed. An arrangement step of arranging the powder supply tube so as to face downward toward the opening; and rotating the powder supply tube at a predetermined speed around the central axis of the powder supply tube into the powder supply tube A supply step of supplying the stored medicine from the opening to the powder filling device in the sterile space ;
A method for supplying powder. In the arranging step, the lowest line bus bar on the inner peripheral surface of the powder supply cylinder is vertically below the horizontal plane, and the angle between the bus bar and the horizontal plane is set within a range of 1 to 10 degrees. The powder supply method according to claim 7 . The powder supply method according to claim 7 , further comprising a step of controlling rotation of the powder supply cylinder in response to a command from a powder filling apparatus to which the powder is supplied. The powder supply method according to claim 7 , further comprising a step of changing a rotation speed of the powder supply cylinder according to a medicine to be supplied. The powder supply method according to claim 7 , further comprising a step of changing a rotation speed of the powder supply cylinder according to a medicine to be supplied and adjusting a central axis of the powder supply cylinder to a predetermined angle with respect to a horizontal plane. . A powder filling apparatus for filling a powder drug disposed in the powder container to the first sterile space, powder supply filling comprising a supplying powder feeder the agent to the powder filling apparatus A device,
The powder supply device is disposed in a second aseptic space partitioned from the first aseptic space by a partition wall.
Used as a container for storing medicine, has an inner cylindrical shape with one end opened and the other end closed, and is formed in the partition wall so that the opening is disposed in the first sterile space When inserted into the insertion hole, the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and the bus bar serving as the lowest end of the inner peripheral surface from the closing surface of the cylinder to the opening is the blocking surface are arranged so as to be downward toward the opening from the said central axis as the center of rotation, the drug housed in said powder feed cylinder by rotating said powder supply tube at a predetermined speed from the opening A powder supply cylinder configured to supply to a powder filling device;
Desorption mechanism provided at the outer end where the closed surface is formed in the powder supply cylinder ,
The powder supply cylinder is mounted by the desorption mechanism, the powder supply cylinder is cantilevered, and the center of the powder supply cylinder is inserted into the first aseptic space with the opening-side end of the powder supply cylinder inserted. A supply cylinder driving unit that rotationally drives the powder supply cylinder around an axis as a rotation center ;
An angle adjustment unit for adjusting the central axis of the powder supply cylinder to a predetermined angle with respect to a horizontal plane ;
A conveyance unit configured to be movable for inserting the opening side end of the powder supply cylinder into the first aseptic space, and a control unit for controlling the supply cylinder driving unit ,
The powder filling device includes:
A powder hopper in which the medicine in the powder supply cylinder is supplied from the opening;
A level sensor that detects a storage level in the powder hopper and outputs a command based on the detection to the control unit;
A powder supply / filling device comprising: a filling mechanism for filling a predetermined amount of the drug in the powder hopper into the powder container at a filling position; and a transport mechanism for sequentially transporting the powder container to the filling position. A powder filling method using a powder filling apparatus for filling a powder container with a powder medicine in a first aseptic space, and a second aseptic space partitioned from the first aseptic space by a partition wall A powder supply and filling method comprising: a powder supply method for supplying the drug to the powder filling device by means of a powder supply device disposed therein,
The closed surface is formed in the powder supply cylinder so that the powder supply cylinder is used as a container for storing a medicine and has a cylindrical inner surface shape in which one end is open and the other end is a closed surface. A mounting step of mounting on a supply cylinder driving unit of the powder supply device via a desorption mechanism provided on the outer end portion ,
The powder supply device is transported to a predetermined position, the powder supply tube is inserted into an insertion hole formed in the partition wall, and the opening in the powder supply tube is in the first aseptic space. Conveying process to be arranged ,
The control unit rotates the powder supply cylinder so that the central axis of the cylinder has a predetermined angle with respect to a horizontal plane, and becomes the lowest end side on the inner peripheral surface from the closed surface of the cylinder to the opening. An arrangement step in which a bus is arranged downward from the closed surface toward the opening;
With the central axis of the powder supply cylinder as the center of rotation, the powder supply cylinder is rotated at a predetermined speed, and the medicine stored in the powder supply cylinder is transferred from the opening into the first aseptic space. Supply process to supply to the powder hopper of the powder filling device ,
A level sensor provided in the powder hopper detects a powder storage level in the powder hopper, and outputs a command based on the detection to the control unit, and sequentially transfers the powder containers to the filling position. A filling step of filling a predetermined amount of powder in the powder hopper into the powder container at the filling position;
A powder supply and filling method. A transfer ring that is attached to the powder supply cylinder in the powder supply apparatus according to claim 1 and is used to transfer the powder medicine stored in the bag body to the powder supply cylinder,
An arcuate least two arc connected by a hinge portion,
Hooking means for fixing the two arcuate bodies to each other and forming an annular shape,
The two arcuate bodies fixed by the hooking means are attached to the opening side end of the powder supply cylinder via the bag, and the connection of the bag in an annular shape formed by the two arcuate bodies A transfer ring configured such that a diameter of an opening portion as a position is smaller than a diameter of the opening. The transfer ring according to claim 14 , wherein a recess is formed on a part of an inner surface of an annular shape formed by two arcuate bodies, and a part of the attached bag is disposed in the recess . In the two arc, through the bag body, an opening side end portion of the powder supply tube is formed with a groove on the part content that will be mounted, the opening side end of the two arc is the powder supply cylinder when mounted through the bag to the parts, according to the powder supply cylinder claim 14 or claim 15 convex portion formed on the opening end portion is configured to be housed in the groove of Transfer ring.

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