JP4616815B2 - A topical skin preparation that gives skin smoothness - Google Patents
A topical skin preparation that gives skin smoothness Download PDFInfo
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- JP4616815B2 JP4616815B2 JP2006281817A JP2006281817A JP4616815B2 JP 4616815 B2 JP4616815 B2 JP 4616815B2 JP 2006281817 A JP2006281817 A JP 2006281817A JP 2006281817 A JP2006281817 A JP 2006281817A JP 4616815 B2 JP4616815 B2 JP 4616815B2
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- skin
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- external preparation
- smoothness
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- 238000002360 preparation method Methods 0.000 title claims description 51
- 230000000699 topical effect Effects 0.000 title 1
- -1 alkyl methacrylate Chemical compound 0.000 claims description 35
- 229920001296 polysiloxane Polymers 0.000 claims description 16
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 13
- 229920001577 copolymer Polymers 0.000 claims description 11
- 239000002537 cosmetic Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 11
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 9
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 9
- QPQANCNBWQXGTQ-UHFFFAOYSA-N trihydroxy(trimethylsilylperoxy)silane Chemical compound C[Si](C)(C)OO[Si](O)(O)O QPQANCNBWQXGTQ-UHFFFAOYSA-N 0.000 claims description 9
- 229940008099 dimethicone Drugs 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 8
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims description 7
- 229920006037 cross link polymer Polymers 0.000 claims description 7
- 229940086555 cyclomethicone Drugs 0.000 claims description 7
- 229960003237 betaine Drugs 0.000 claims description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims 1
- 230000000694 effects Effects 0.000 description 23
- 239000007787 solid Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 230000003020 moisturizing effect Effects 0.000 description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 12
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 9
- 230000000877 morphologic effect Effects 0.000 description 9
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 8
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 8
- 229920002125 Sokalan® Polymers 0.000 description 8
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 8
- 230000006872 improvement Effects 0.000 description 7
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 6
- 241000894007 species Species 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 229940067596 butylparaben Drugs 0.000 description 4
- 235000012000 cholesterol Nutrition 0.000 description 4
- 229940075507 glyceryl monostearate Drugs 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 4
- 229960002216 methylparaben Drugs 0.000 description 4
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
- 229960002446 octanoic acid Drugs 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000004200 microcrystalline wax Substances 0.000 description 3
- 235000019808 microcrystalline wax Nutrition 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 150000003431 steroids Chemical class 0.000 description 3
- IFYVAPPYWOMVDP-ZDUSSCGKSA-N 3-[[(2r)-2,4-diacetyloxy-3,3-dimethylbutanoyl]amino]propyl acetate Chemical compound CC(=O)OCCCNC(=O)[C@H](OC(C)=O)C(C)(C)COC(C)=O IFYVAPPYWOMVDP-ZDUSSCGKSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 201000008937 atopic dermatitis Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 150000004679 hydroxides Chemical class 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- ILJSQTXMGCGYMG-UHFFFAOYSA-N triacetic acid Chemical compound CC(=O)CC(=O)CC(O)=O ILJSQTXMGCGYMG-UHFFFAOYSA-N 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- OIKBVOIOVNEVJR-UHFFFAOYSA-N hexadecyl 6-methylheptanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)CCCCC(C)C OIKBVOIOVNEVJR-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 230000004215 skin function Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical group C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、皮膚外用剤に関し、更に詳細には、皮膚になめらかさを付与するための化粧料に好適な皮膚外用剤に関する。 The present invention relates to an external preparation for skin, and more particularly to an external preparation for skin suitable for cosmetics for imparting smoothness to the skin.
皮膚外用剤において、皮膚になめらかさを与えることは、化粧料に限らず重要なことである。例えば、アトピー性皮膚炎などに於いては、主剤のステロイド剤は同一であっても、どの様な剤形のものを使うかによって、その効果は著しく異なることが知られている。これはステロイド剤の吸収特性の差によるばかりではなく、製剤自身の肌の保湿性に与える影響も多いと言われている。この様な現象は、アトピー性皮膚炎や、ステロイド剤にのみ限られて観察されることではなく、皮膚に関する疾患或いは、化粧料の対象とする皮膚を健やかに保つこと全般にわたって言えることであり、それだけ皮膚機能に於ける保水性の果たす役割が多いことの証明でもある。又、肌が正常な形態を保つ上でも、保湿性の因子は重要である。 In the external preparation for skin, it is important not only for cosmetics but to give smoothness to the skin. For example, in atopic dermatitis, it is known that even if the main steroid is the same, the effect is remarkably different depending on what dosage form is used. This is not only due to the difference in absorption characteristics of steroids, but is also said to have many effects on the skin's moisture retention. Such a phenomenon is not observed only in atopic dermatitis or steroids, but can be said throughout the disease related to the skin or keeping the skin targeted for cosmetics healthy, It is also proof that there are many roles of water retention in skin function. Also, the moisturizing factor is important for maintaining the normal form of the skin.
この様な保湿性の付与や維持のために行われる製剤的な技術としては、ヒアルロン酸ナトリウムやコラーゲンなどの保湿性高分子の添加、グリセリン或いはポリエチレングリコール等の多価アルコールの添加、アミノ酸などのＮＭＦ（ナチュラル・モイスチャリング・ファクター）成分の添加、スクワレン等のナチュラルエモリント・ファクターなどの添加、マイクロクリスタリンワックス等のワックス性成分による閉塞による水の散逸防止などが挙げられる。しかし、これらの方法で保湿性の付与はできるものの、肌のなめらかさの維持など形態的な特性への働きには、充分とは言い難い部分があった。即ち、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も有する皮膚外用剤用の製剤の開発が望まれていた。加えて、使用感の面からはマイクロクリスタリンワックスなどのワックス系を含まない、伸びの良いジェル状の製剤が望まれていた。 Examples of the pharmaceutical technology used for imparting and maintaining such moisturizing properties include the addition of moisturizing polymers such as sodium hyaluronate and collagen, the addition of polyhydric alcohols such as glycerin or polyethylene glycol, and amino acids. Examples thereof include addition of an NMF (natural moisturizing factor) component, addition of a natural emollient factor such as squalene, and prevention of water dissipation due to blockage by a waxy component such as microcrystalline wax. However, although moisturizing property can be imparted by these methods, there is a part that is not sufficient for the action on morphological characteristics such as maintaining the smoothness of the skin. That is, it has been desired to develop a preparation for an external preparation for skin that has a moisturizing effect and also has a skin morphological improving effect such as a smoothing effect. In addition, a gel-like preparation with good elongation that does not contain a wax system such as microcrystalline wax has been desired from the viewpoint of usability.
一方、１）高粘度乃至は固体のシリコーンから選ばれる１種乃至は２種以上と２）アクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体とを含有することを特徴とする皮膚外用剤は全く知られていないし、この様な構成の皮膚外用剤が、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も有することも全く知られていない。 On the other hand, an external preparation for skin comprising 1) one or more selected from high viscosity or solid silicone and 2) a copolymer of acrylic acid / alkyl methacrylate (C10-30) Is not known at all, and it is also known that a skin external preparation with such a constitution has a moisturizing effect and also has a skin morphological improvement effect such as a smoothness-imparting effect. Not.
本発明は、この様な状況下為されたものであり、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も有する皮膚外用剤を提供することを課題とする。 The present invention has been made under such circumstances, and provides an external preparation for skin that has a moisturizing effect and also has a skin morphological improvement effect such as a smoothness-imparting effect. This is the issue.
本発明者らは、この様な状況に鑑みて、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も有する皮膚外用剤を求めて、鋭意研究努力を重ねた結果、トリメチルシロキシケイ酸と、アクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体とを含有させ、ジェル状の皮膚外用剤とすることにより、保湿性の付与効果と皮膚の形態的な改善作用を有させ得ることを見出し、発明を完成させるに至った。即ち、本発明は以下に示す技術に関するものである。
（１）Ａ）トリメチルシロキシケイ酸と、Ｂ）アクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体と、Ｃ）液状シリコーンであるジメチコン、シクロメチコン及びジメチコンクロスポリマーとを含有し、ジェル状であることを特徴とする皮膚外用剤。
（２） 前記液状シリコーンの含有量が４．２〜１０重量％であることを特徴とする、（１）に記載の皮膚外用剤。
（３） 更に、ベタインを含有することを特徴とする、（１）又は（２）に記載の皮膚外用剤。
（４） ボディー用の化粧料であることを特徴とする、（１）〜（３）の何れかに記載の皮膚外用剤。
（５） 皮膚へのなめらかさの付与用であることを特徴とする、（１）〜（４）の何れかに記載の皮膚外用剤。
以下、本発明について更に詳細に説明を加える。
In view of such circumstances, the present inventors have eagerly sought for an external preparation for skin that has a moisturizing effect and also has a skin morphological improvement effect such as a smoothing effect. As a result of repeated research efforts, by adding trimethylsiloxysilicic acid and an acrylic acid / alkyl methacrylate (C10-30) copolymer to form a gel-like skin external preparation, moisturizing effect and skin The present inventors have found that it is possible to have a morphological improvement effect of and have completed the invention. That is, the present invention relates to the following technique.
(1) A) containing trimethylsiloxysilicic acid, B) acrylic acid / alkyl methacrylate (C10-30) copolymer, and C) liquid silicone dimethicone, cyclomethicone and dimethicone crosspolymer , in a gel form An external preparation for skin characterized by
(2) The external preparation for skin according to (1), wherein the content of the liquid silicone is 4.2 to 10% by weight.
(3) Furthermore, betaine is contained, The skin external preparation as described in (1) or (2) characterized by the above-mentioned.
(4) The external preparation for skin according to any one of (1) to (3), which is a cosmetic for a body.
(5) The external preparation for skin according to any one of (1) to (4), which is for imparting smoothness to the skin.
Hereinafter, the present invention will be described in more detail.
本発明によれば、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も有する皮膚外用剤を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, while having the moisturizing provision effect, it can provide the skin external preparation which also has the morphological improvement effect of skin, such as a smooth provision effect.
（１）本発明の皮膚外用剤の必須成分である高粘度乃至は固体のシリコーン
本発明の皮膚外用剤は高粘度乃至は固体のシリコーンを必須成分として含有する。かかる高粘度乃至は固体のシリコーンとしては、メチル基等のアルキル基と珪素−酸素−珪素結合とを有するものであって高粘度乃至は固体のものであれば、特段の限定はなく、例えば、アルキルポリシロキサン、架橋型アルキルポリシロキサン、トリアルキルシロキシ珪酸、アルキルポリシロキサン網状重合体などが好ましく例示でき、メチルポリシロキサン、架橋型メチルポリシロキサン又はトリメチルシロキシケイ酸の構造であって、高粘度液体乃至は固体のものが更に好ましく、高粘度液体としては粘度３００００ｍＰａｓｃａｌ・ｓｅｃ以上のものが例示でき、更に好ましくは、３５０００ｍＰａｓｃａｌ・ｓｅｃ〜５００００ｍＰａｓｃａｌ・ｓｅｃのものが例示できる。固形のものとしては、所謂シリコーンエラストマーと呼ばれる弾性を有する固体が好ましく例示できる。これらの高粘度乃至は固体のシリコーンは唯一種を含有させることもできるし、二種以上を組み合わせて含有させることもできる。本発明の皮膚外用剤において、保湿性の付与効果を有しつつ、且つ、なめらかさの付与効果などの皮膚の形態的な改善作用も付与する作用を充分に発揮する為には、これらの高粘度乃至は固体のシリコーンの含有量は皮膚外用剤全量に対して、総量で０．０５〜１０重量％が好ましく、０．１〜５重量％が更に好ましい。これは少なすぎると効果を発揮しない場合があり、多すぎると使用感を損なう場合があるからである。
(1) High-viscosity or solid silicone that is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains high-viscosity or solid silicone as an essential component. Such high-viscosity or solid silicone is not particularly limited as long as it has an alkyl group such as a methyl group and a silicon-oxygen-silicon bond and is high-viscosity or solid. Preferred examples include alkylpolysiloxanes, cross-linked alkylpolysiloxanes, trialkylsiloxysilicic acids, and alkylpolysiloxane network polymers, which have a structure of methylpolysiloxane, cross-linked methylpolysiloxane, or trimethylsiloxysilicic acid and have a high viscosity liquid. The solid liquid is more preferable, and the high-viscosity liquid can be exemplified by those having a viscosity of 30000 mPascal · sec or more, more preferably 35000 mPascal · sec to 50000 mPascal · sec. As a solid thing, the solid which has elasticity called what is called a silicone elastomer can be illustrated preferably. These high-viscosity or solid silicones can contain only one species or a combination of two or more species. In the preparation for external use of the skin of the present invention, in order to sufficiently exert the action of imparting moisturizing effect and also imparting the morphological improvement effect of the skin such as the effect of imparting smoothness, The total amount of the viscosity or solid silicone is preferably 0.05 to 10% by weight, more preferably 0.1 to 5% by weight, based on the total amount of the external preparation for skin. This is because if the amount is too small, the effect may not be exhibited, and if the amount is too large, the feeling of use may be impaired.
（２）本発明の皮膚外用剤の必須成分であるアクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体
本発明の皮膚外用剤は、アクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体とを含有することを特徴とする。かかるアクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体はフリー体で含有させることもできるし、ナトリウム、カリウムなどのアルカリ金属の水酸化物、カルシウム、マグネシウムなどのアルカリ土類金属の水酸化物、アンモニア、有機アミン、塩基性アミノ酸などの塩基などで中和して、塩として含有させることもできる。塩としてはアルカリ金属の塩が特に好ましく例示できる。この様な共重合体は、皮膚外用剤の分野において、乳化作用を有する増粘剤として使用されている。本発
明の皮膚外用剤においては、べたつくことなく、なめらかさを付与する作用を発現する。この様なアクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体としては、既に市販されているものがあり、この様なものを利用することができる。この様な市販品の内、特に好ましいものとしては、グッドリッチ社から市販されている、カーボポール１３８２、ペムレンＴＲ−１、ペムレンＴＲ−２等が例示できる。これらのアクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体は唯一種を含有することもできるし、二種以上を組み合わせて含有させることもできる。本発明の皮膚外用剤における、アクリル酸・メタクリル酸アルキル（Ｃ１０〜３０）共重合体の好ましい含有量は、皮膚外用剤全量に対して、総量で０．０５〜５重量％が好ましく、更に好ましくは、０．１〜１重量％である。これは少なすぎるとなめらかさの付与効果を発揮できない場合があり、多すぎると粘度が高くなりすぎ、使用性が損なわれる場合があるからである。
(2) Acrylic acid / alkyl methacrylate (C10-30) copolymer which is an essential component of the skin external preparation of the present invention The skin external preparation of the present invention is an acrylic acid / alkyl methacrylate (C10-30) copolymer. It is characterized by containing. Such an acrylic acid / alkyl methacrylate (C10-30) copolymer can be contained in a free form, or hydroxides of alkali metals such as sodium and potassium, and hydroxides of alkaline earth metals such as calcium and magnesium. It can also be neutralized with a base such as a product, ammonia, an organic amine, or a basic amino acid, and contained as a salt. Particularly preferred examples of the salt include alkali metal salts. Such a copolymer is used as a thickener having an emulsifying action in the field of external preparation for skin. The external preparation for skin of the present invention exhibits an effect of imparting smoothness without stickiness. As such acrylic acid / alkyl methacrylate (C10-30) copolymers, there are those already on the market, and such ones can be used. Among such commercially available products, carbopol 1382, pemlen TR-1, pemlen TR-2, etc., commercially available from Goodrich, can be exemplified. These acrylic acid / alkyl methacrylate (C10-30) copolymers may contain only one species, or may contain two or more species in combination. The preferable content of the acrylic acid / alkyl methacrylate (C10-30) copolymer in the external preparation for skin of the present invention is preferably 0.05 to 5% by weight, more preferably based on the total amount of external preparation for skin. Is 0.1 to 1% by weight. This is because if the amount is too small, the effect of imparting smoothness may not be exhibited. If the amount is too large, the viscosity becomes too high, and the usability may be impaired.
（３）本発明の皮膚外用剤
本発明の皮膚外用剤は、上記の必須成分を含有することを特徴とする。この様な構成を取ることにより、本発明の皮膚外用剤は保湿性の付与効果と皮膚の形態的な改善作用を有する。ここで、本発明で言う皮膚外用剤とは、皮膚に外用で投与される組成物の総称であり、化粧料、皮膚外用医薬組成物、皮膚外用雑貨等が好ましく例示できる。本発明の皮膚外用剤としては、化粧料が特に好ましい。これは、保湿性と皮膚のなめらかさが化粧料においては極めて重要な課題であるからである。又、化粧料としては、特段の限定はないが、体部に適用するものが特に好ましい。又、製剤形態としてはクリームや粘凋ローションとしても使用できるが、ジェル製剤で使用することが特に好ましい。これは皮膚上への残り量が適切であるからである。本発明の皮膚外用剤に於いては、前記必須成分以外に通常皮膚外用剤で使用される任意成分を含有することができる。この様な任意成分としては、例えば、ワセリンやマイクロクリスタリンワックス等のような炭化水素類、ホホバ油やセチルイソオクタネート等のエステル類、オリーブ油等のトリグリセライド類、オクタデシルアルコールやオレイルアルコール等の高級アルコール類、グリセリンや１，３−ブタンジオール、１，２−ペンタンジオール、イソプレングリコール、ジプロピレングリコール等の多価アルコール類、非イオン界面活性剤、アニオン界面活性剤、カチオン界面活性剤、両性界面活性剤、エタノール、カーボポール等の増粘剤、防腐剤、紫外線吸収剤、抗酸化剤類等が例示できる。これらの中で、特に好ましい成分としては、トリメチルグリシン等のベタイン類が例示できる。これらは、保湿性と皮膚のなめらかさを更に高める作用に優れる為である。かかるベタイン類は唯一種を含有されることもできるし、二種以上を組み合わせて含有させることもできる。かかるベタイン類の好ましい含有量は、化粧料全量に対して、総量で０．１〜１０重量％が好ましく、より好ましくは０．５〜５重量％である。これは少なすぎると、保湿効果、なめらかさ付与増強効果を発揮しない場合があり、多すぎるとべたつき感が出て、使用性を損なう場合があるからである。又、必須成分である高粘度乃至は固形シリコーンと他の成分の相溶性を高めるため、液状のジメチコン、フェメチコン、シクロメチコン、アモジメチコン、或いはジメチコンクロスポリマーなどのシリコーンを含有することも好ましい。この様な液状シリコーンの好ましい含有量は、総量で、皮膚外用剤全量に対して４．２〜１０重量％である。本発明の皮膚外用剤はこれら必須の成分と任意の成分とを常法に従って処理することにより製造することができる。
(3) Skin external preparation of this invention The skin external preparation of this invention contains said essential component, It is characterized by the above-mentioned. By taking such a structure, the skin external preparation of this invention has a moisturizing provision effect and a skin morphological improvement effect. Here, the external preparation for skin referred to in the present invention is a general term for compositions that are externally applied to the skin, and preferred examples include cosmetics, external pharmaceutical compositions for skin, and sundry goods. As the skin external preparation of the present invention, cosmetics are particularly preferable. This is because moisture retention and smooth skin are extremely important issues in cosmetics. The cosmetic is not particularly limited, but is preferably applied to the body part. Moreover, although it can be used as a cream or a viscous lotion as a preparation form, it is particularly preferable to use it as a gel preparation. This is because the remaining amount on the skin is appropriate. In the external preparation for skin of the present invention, optional components usually used in external preparations for skin can be contained in addition to the essential components. Examples of such optional components include hydrocarbons such as petrolatum and microcrystalline wax, esters such as jojoba oil and cetyl isooctanoate, triglycerides such as olive oil, and higher alcohols such as octadecyl alcohol and oleyl alcohol. , Polyhydric alcohols such as glycerin, 1,3-butanediol, 1,2-pentanediol, isoprene glycol, dipropylene glycol, nonionic surfactant, anionic surfactant, cationic surfactant, amphoteric surfactant Examples thereof include thickeners such as agents, ethanol and carbopol, preservatives, ultraviolet absorbers, antioxidants and the like. Among these, particularly preferred components include betaines such as trimethylglycine. This is because they are excellent in the action of further enhancing the moisture retention and the smoothness of the skin. Such betaines may contain only one species, or may contain two or more species in combination. The preferred content of such betaines is preferably from 0.1 to 10% by weight, more preferably from 0.5 to 5% by weight, based on the total amount of the cosmetic. This is because if the amount is too small, the moisturizing effect and smoothness-improving effect may not be exhibited. If the amount is too large, a sticky feeling may be produced and the usability may be impaired. Furthermore, to enhance the high viscosity to the compatibility of the solid silicone and other components are essential components, liquid dimethicone, Femechikon, cyclomethicone, amodimethicone, some have it also preferably contains a silicone such as dimethicone crosspolymer . A preferable content of such liquid silicone is 4.2 to 10% by weight based on the total amount of the external preparation for skin. The external preparation for skin of the present invention can be produced by treating these essential components and optional components according to a conventional method.
以下に、実施例を挙げて、本発明について、更に詳細に説明を加えるが、本発明がこれら実施例にのみ限定されないことは言うまでもない。 Hereinafter, the present invention will be described in more detail with reference to examples, but it goes without saying that the present invention is not limited only to these examples.
＜実施例１＞
以下に示す処方に従って、本発明の皮膚外用剤である、ボディー用のジェル（化粧料）を作成した。即ち、イ、ロ、ハの成分をそれぞれ７０℃に加熱し、イの成分に徐々にロの
成分を加え乳化し、ホモジナイザーで粒子を均質化し、ハを加えて中和、増粘させ、攪拌冷却して本発明の皮膚外用剤１を得た。
イ
ジメチコン（１０ｍＰａｓｃａｌ・ｓｅｃ） ２ 重量部
メチルシロキサンクロスポリマー ２ 重量部
トリメチルシロキシケイ酸（固体） ０．３重量部
シクロメチコン ０．３重量部
ブチルパラベン ０．１重量部
コレステロール（カプリル酸／カプリン酸）エステル ２ 重量部
トリ酢酸パントテニル ０．１重量部
ＰＯＥ（２５）ステアレート ０．６重量部
グリセリルモノステアレート ０．４重量部
トリメチルグリシン １ 重量部
ロ
１，３−ブタンジオール ５ 重量部
グリセリン ５ 重量部
ポリエチレン粉末 ０．５重量部
ケルトロール ０．２重量部
カーボポール１３８２ ０．５重量部
メチルパラベン ０．２重量部
水 ５０ 重量部
ハ
１０％水酸化カリウム ２．５重量部
水 ２９．３重量部
<Example 1>
According to the formulation shown below, a gel (cosmetic) for body, which is an external preparation for skin of the present invention, was prepared. In other words, the ingredients i, b, and c are each heated to 70 ° C, the ingredient b is gradually added to the ingredient i, emulsified, and the particles are homogenized with a homogenizer, neutralized and thickened by adding c, and stirred. It cooled and the skin external preparation 1 of this invention was obtained.
Idimethicone (10 mPascal · sec) 2 parts by weight methylsiloxane crosspolymer 2 parts by weight trimethylsiloxysilicic acid (solid) 0.3 part by weight cyclomethicone 0.3 part by weight butylparaben 0.1 part by weight cholesterol (caprylic acid / capric acid ) Ester 2 parts by weight Pantothenyl triacetate 0.1 parts by weight POE (25) stearate 0.6 parts by weight Glyceryl monostearate 0.4 parts by weight Trimethylglycine 1 part by weight 1,3-butanediol 5 parts by weight glycerin 5 Parts by weight polyethylene powder 0.5 parts by weight celtrol 0.2 parts by weight Carbopol 1382 0.5 parts by weight methylparaben 0.2 parts by weight water 50 parts by weight 10% potassium hydroxide 2.5 parts by weight water 29.3 parts by weight Part
＜実施例２＞
皮膚外用剤１について、このもののカーボポール１３８２を、カルボキシビニルポリマーに置換した比較例１、トリメチルシロキシケイ酸を液状のジメチコン（１００ｍＰａｓｃａｌ・ｓｅｃ）に置換した比較例２、カーボポール１３８２を、カルボキシビニルポリマーに、トリメチルシロキシケイ酸を液状のジメチコン（１００ｍＰａｓｃａｌ・ｓｅｃ）に置換した対照例１とともに、適用前後における散逸水分量変化と専門パネラーを用いた官能評価で評価した。散逸水分量変化は（使用前の散逸水分量−使用後の散逸水分量）／（使用前の散逸水分量）×１００（％）で表される散逸抑制率の平均値（ｎ＝５）として評価し、官能評価はなめらかさ、べたつきの無さを、スコア５：非常によい、スコア４：良い、スコア３：やや良い、スコア２：やや悪い、スコア１：悪いのスコアを用いて評価した。結果を表１に示す。これより、本発明の皮膚外用剤は、保湿性と皮膚のなめらかさの改善作用に優れることが判る。
<Example 2>
For external preparation 1 for skin, Comparative Example 1 in which carbopol 1382 was replaced with carboxyvinyl polymer, Comparative Example 2 in which trimethylsiloxysilicate was replaced with liquid dimethicone (100 mPascal · sec), and Carbopol 1382 were replaced with carboxyvinyl. Along with Control Example 1 in which trimethylsiloxysilicic acid was replaced with liquid dimethicone (100 mPascal · sec), the polymer was evaluated by sensory evaluation using a change in dissipated moisture before and after application and a specialized panel. Change in dissipated water amount is (dissipated water amount before use-dissipated water amount after use) / (dissipated water amount before use) x 100 (%) as the average value of the dissipation suppression rate (n = 5) Evaluation, sensory evaluation was smooth and non-sticky, score 5: very good, score 4: good, score 3: slightly good, score 2: slightly bad, score 1: bad . The results are shown in Table 1. From this, it can be seen that the external preparation for skin of the present invention is excellent in improving the moisture retention and smoothness of the skin.
＜実施例３、４＞
実施例１と同様に、アクリル酸・メタクリル酸（Ｃ１０〜３０）アルキルの種類を変え検討を行った。評価は実施例２と同様に行った。結果を表２に示す。何れのアクリル酸・
メタクリル酸（Ｃ１０〜３０）アルキルも同様の効果を発揮していることが判る。
イ
ジメチコン（１０ｍＰａｓｃａｌ・ｓｅｃ） ２ 重量部
メチルシロキサンクロスポリマー ２ 重量部
トリメチルシロキシケイ酸（固体） ０．３重量部
シクロメチコン ５．４重量部
ブチルパラベン ０．１重量部
コレステロール（カプリル酸／カプリン酸）エステル ２ 重量部
トリ酢酸パントテニル ０．１重量部
ＰＯＥ（２５）ステアレート ０．６重量部
グリセリルモノステアレート ０．４重量部
トリメチルグリシン １ 重量部
ロ
１，３−ブタンジオール ５ 重量部
グリセリン ５ 重量部
ポリエチレン粉末 ０．５重量部
ケルトロール ０．２重量部
アクリル酸／メタクリル酸アルキル＊ ０．５重量部
メチルパラベン ０．２重量部
水 ５０ 重量部
ハ
１０％水酸化カリウム ２．５重量部
水 ２９．３重量部
＊詳細は表２に示す。
<Examples 3 and 4>
In the same manner as in Example 1, the types of acrylic acid / methacrylic acid (C10-30) alkyl were changed and examined. Evaluation was performed in the same manner as in Example 2. The results are shown in Table 2. Any acrylic acid
It turns out that the methacrylic acid (C10-30) alkyl is also exhibiting the same effect.
Idimethicone (10 mPascal · sec) 2 parts by weight methylsiloxane crosspolymer 2 parts by weight trimethylsiloxysilicic acid (solid) 0.3 part by weight cyclomethicone 5.4 parts by weight butylparaben 0.1 part by weight cholesterol (caprylic acid / capric acid ) Ester 2 parts by weight Pantothenyl triacetate 0.1 parts by weight POE (25) stearate 0.6 parts by weight Glyceryl monostearate 0.4 parts by weight Trimethylglycine 1 part by weight 1,3-butanediol 5 parts by weight glycerin 5 Parts by weight polyethylene powder 0.5 parts by weight celtrol 0.2 parts by weight acrylic acid / alkyl methacrylate * 0.5 parts by weight methylparaben 0.2 parts by weight water 50 parts by weight 10% potassium hydroxide 2.5 parts by weight water 29.3 parts by weight * Details are given in Table 2.
＜実施例５〜９＞
実施例１の皮膚外用剤１の高粘度乃至は固形シリコーンの種類を変えて、実施例２と同様の検討を行った。結果を表３に示す。これより、何れのシリコーンも使用可能であることが判る。皮膚外用剤１との比較より、中でも、トリメチルシロキシケイ酸が特に好ましいことが判る。
イ
ジメチコン（１０ｍＰａｓｃａｌ・ｓｅｃ） ２ 重量部
メチルシロキサンクロスポリマー ２ 重量部
高粘度乃至は固体シリコーン＊＊ ０．３重量部
シクロメチコン ５．４重量部
ブチルパラベン ０．１重量部
コレステロール（カプリル酸／カプリン酸）エステル ２ 重量部
トリ酢酸パントテニル ０．１重量部
ＰＯＥ（２５）ステアレート ０．６重量部
グリセリルモノステアレート ０．４重量部
トリメチルグリシン １ 重量部
ロ
１，３−ブタンジオール ５ 重量部
グリセリン ５ 重量部
ポリエチレン粉末 ０．５重量部
ケルトロール ０．２重量部
カーボポール１３８２ ０．５重量部
メチルパラベン ０．２重量部
水 ５０ 重量部
ハ
１０％水酸化カリウム ２．５重量部
水 ２４．６重量部
<Examples 5-9>
The same investigation as in Example 2 was performed by changing the high viscosity or solid silicone type of the external preparation for skin 1 of Example 1. The results are shown in Table 3. This shows that any silicone can be used. From comparison with the external preparation for skin 1, it can be seen that trimethylsiloxysilicic acid is particularly preferable.
Idimethicone (10 mPascal · sec) 2 parts by weight methylsiloxane crosspolymer 2 parts by weight high viscosity or solid silicone ** 0.3 part by weight cyclomethicone 5.4 parts by weight butylparaben 0.1 part by weight cholesterol (caprylic acid / caprin Acid) ester 2 parts by weight pantothen triacetate 0.1 part by weight POE (25) stearate 0.6 part by weight glyceryl monostearate 0.4 part by weight trimethylglycine 1 part by weight b- 1,3-butanediol 5 parts by weight glycerin 5 parts by weight polyethylene powder 0.5 parts by weight Celtolol 0.2 parts by weight Carbopol 1382 0.5 parts by weight methylparaben 0.2 parts by weight water 50 parts by weight 10% potassium hydroxide 2.5 parts by weight water 24.6 Parts by weight
＜実施例１０＞
実施例１の皮膚外用剤１の処方のトリメチルグリシンを水に置換して、実施例２と同様の検討を行った。実施例２と同様に評価を行ったところ、５人平均の散逸水分抑制率が２３％であり、皮膚のなめらかさのスコアがスコア４であり、トリメチルグリシンを含有することが好ましいことが判った。
イ
ジメチコン（１０ｍＰａｓｃａｌ・ｓｅｃ） ３ 重量部
メチルシロキサンクロスポリマー ０．６重量部
トリメチルシロキシケイ酸（固体） ０．３重量部
シクロメチコン ５．４重量部
ブチルパラベン ０．１重量部
コレステロール（カプリル酸／カプリン酸）エステル ２ 重量部
トリ酢酸パントテニル ０．１重量部
ＰＯＥ（２５）ステアレート ０．６重量部
グリセリルモノステアレート ０．４重量部
ロ
１，３−ブタンジオール ２ 重量部
グリセリン ８ 重量部
ポリエチレン粉末 ０．５重量部
ケルトロール ０．２重量部
カーボポール１３８２ ０．５重量部
メチルパラベン ０．２重量部
水 ５０ 重量部
ハ
１０％水酸化カリウム ２．５重量部
水 ２４．６重量部
<Example 10>
The same investigation as in Example 2 was performed by replacing trimethylglycine in the formulation of the external preparation for skin 1 of Example 1 with water. Evaluation was conducted in the same manner as in Example 2. As a result, it was found that the average dissipated water suppression rate of 5 people was 23%, the score of the smoothness of the skin was score 4, and it was preferable to contain trimethylglycine. .
Idimethicone (10 mPascal · sec) 3 parts by weight Methylsiloxane crosspolymer 0.6 part by weight Trimethylsiloxysilicic acid (solid) 0.3 part by weight cyclomethicone 5.4 parts by weight butylparaben 0.1 part by weight cholesterol (caprylic acid / Capric acid) ester 2 parts by weight Pantothene triacetate 0.1 part by weight POE (25) stearate 0.6 part by weight glyceryl monostearate 0.4 part by weight 1,3-butanediol 2 parts by weight glycerin 8 parts by weight polyethylene Powder 0.5 parts by weight Celtolol 0.2 parts by weight Carbopol 1382 0.5 parts by weight Methylparaben 0.2 parts by weight Water 50 parts by weight 10% potassium hydroxide 2.5 parts by weight Water 24.6 parts by weight
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| JP2006281817A JP4616815B2 (en) | 2006-10-16 | 2006-10-16 | A topical skin preparation that gives skin smoothness |
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| Application Number | Priority Date | Filing Date | Title |
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| JP2006281817A JP4616815B2 (en) | 2006-10-16 | 2006-10-16 | A topical skin preparation that gives skin smoothness |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2001375860A Division JP2003171259A (en) | 2001-12-10 | 2001-12-10 | Skin care preparation imparting smoothness to skin |
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| JP2007008961A JP2007008961A (en) | 2007-01-18 |
| JP4616815B2 true JP4616815B2 (en) | 2011-01-19 |
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| JP2006281817A Expired - Lifetime JP4616815B2 (en) | 2006-10-16 | 2006-10-16 | A topical skin preparation that gives skin smoothness |
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| JP6526462B2 (en) * | 2015-03-31 | 2019-06-05 | 小林製薬株式会社 | Composition for external use |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01190757A (en) * | 1988-01-26 | 1989-07-31 | Kobayashi Kose Co Ltd | Silicone gel composition and cosmetic containing same |
| JPH02288817A (en) * | 1989-03-02 | 1990-11-28 | Richardson Vicks Inc | Cosmetics stick |
| JPH0789834A (en) * | 1993-09-21 | 1995-04-04 | Noevir Co Ltd | Anti-suntan cosmetic |
| JPH08501488A (en) * | 1992-07-09 | 1996-02-20 | ロレアル | Cosmetic composition in the form of a water / silicone oil / water gelled ternary emulsion |
| JPH09255523A (en) * | 1996-03-25 | 1997-09-30 | Shiseido Co Ltd | Cosmetic |
| JPH11180823A (en) * | 1997-12-22 | 1999-07-06 | Shiseido Co Ltd | Oil-in-water type emulsion cosmetic |
| JP2001122726A (en) * | 1999-10-27 | 2001-05-08 | Pias Arise Kk | Epidermal cell growth inhibitor and cosmetic, quasi-drug and skin preparation for external use each containing the same |
| JP2003508478A (en) * | 1999-09-09 | 2003-03-04 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | Skin Balance Moisturizing Cream |
-
2006
- 2006-10-16 JP JP2006281817A patent/JP4616815B2/en not_active Expired - Lifetime
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01190757A (en) * | 1988-01-26 | 1989-07-31 | Kobayashi Kose Co Ltd | Silicone gel composition and cosmetic containing same |
| JPH02288817A (en) * | 1989-03-02 | 1990-11-28 | Richardson Vicks Inc | Cosmetics stick |
| JPH08501488A (en) * | 1992-07-09 | 1996-02-20 | ロレアル | Cosmetic composition in the form of a water / silicone oil / water gelled ternary emulsion |
| JPH0789834A (en) * | 1993-09-21 | 1995-04-04 | Noevir Co Ltd | Anti-suntan cosmetic |
| JPH09255523A (en) * | 1996-03-25 | 1997-09-30 | Shiseido Co Ltd | Cosmetic |
| JPH11180823A (en) * | 1997-12-22 | 1999-07-06 | Shiseido Co Ltd | Oil-in-water type emulsion cosmetic |
| JP2003508478A (en) * | 1999-09-09 | 2003-03-04 | ジョンソン・アンド・ジョンソン・リサーチ・ピー・ティー・ワイ・リミテッド | Skin Balance Moisturizing Cream |
| JP2001122726A (en) * | 1999-10-27 | 2001-05-08 | Pias Arise Kk | Epidermal cell growth inhibitor and cosmetic, quasi-drug and skin preparation for external use each containing the same |
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|---|---|
| JP2007008961A (en) | 2007-01-18 |
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