JP3500805B2 - Denture cleaner - Google Patents

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a denture cleansing agent which has both a cleaning power for denture stains and an effect of preventing discoloration / corrosion of a metal for dentures, and has good storage and solidification stability.

[0002]

2. Description of the Related Art Denture stains include food residues, denture plaques, stains (colored deposits: tea astringent stains), etc. Of these, food residues and denture plaques are relatively easy to brush. However, stains are difficult to remove by these methods. However, since dentures are made of resin and metal not only on the teeth but also on the palate mucosa and gingiva, the area covered by stains is large and stains are easily noticeable. It is not preferable from the viewpoint, and a denture cleansing agent that can effectively remove stain is desired.

Further, in partial dentures which occupy half of the dentures having a plate, it is difficult to clean metal parts such as clasps and bars with a dentifrice or the like. Therefore, the use of a denture cleanser is also effective in this respect.

On the other hand, as a denture cleansing agent, a mixture of oxygen bleaching components such as potassium monopersulfate and sodium perborate as a bleaching component is known and known. For example, JP-A-47-11596, Kosho 60-35325
No. 5, JP-A-55-55110, JP-B-63-2556
4, JP-A-58-180420 and JP-A-60-1166.
No. 25, No. 60-126216, No. 61-36216.
No. 61-225116, No. 63-86799,
63-101313, JP-A-1-125316,
It is proposed in Japanese Patent Laid-Open No. 22222/1990.

However, the denture cleaner containing such an oxygen-based bleaching component has a problem that it is difficult to simultaneously satisfy the denture cleaning effect and the blackening / corrosion preventing effect of the denture metal. In some cases, the storage stability was not satisfactory.

Regarding the problem of storage stability, the following measures have been taken. That is, in the oxygen-based bleaching component, potassium monopersulfate is an acidic substance, and sodium perborate is an alkaline substance, so that it is susceptible to hydrolysis by moisture absorption or water in the raw material, and is chemically unstable. . Therefore, in order to suppress the hydrolysis in the denture cleanser and stabilize the peroxide, the above oxygen-based bleaching component is sodium sulfate, an inorganic substance such as silicate or a water-soluble polymer such as polyvinylpyrrolidone or sodium carboxymethylcellulose. It was coated with a compound to stabilize it.

[0007] However, the coating treatment with a peroxide causes an increase in manufacturing cost and has many restrictions in manufacturing, and a simpler method has been demanded.

Under these circumstances, therefore, there has been a demand for the development of a denture cleansing agent having a satisfactory level in all of the above problems.

The present invention has been made in order to meet the above-described demands, and is excellent in cleaning denture stains, particularly stain stains such as brown astringent, and is also excellent in preventing discoloration and corrosion of denture metal. An object is to provide a denture cleansing agent having storage stability.

[0010]

Means for Solving the Problems and Modes for Carrying Out the Invention The present inventor has conducted diligent studies to achieve the above object, and as a result, does not contain an organic acid or a salt thereof as a foaming component and is a stain removing component. As the oxygen bleaching component, potassium monopersulfate (component A) and sodium perborate (component B) are used in a weight ratio of A / B = 1 / 4.5 to 1/10, A + B = 45.
The content of the inorganic condensed phosphate is 5 to 30% by weight of the whole, and the pH value of the 1% by weight aqueous solution is 8 to 11, so that the denture stains, especially the astringent astringency can be obtained. In addition to being excellent in cleaning stain stains such as
The metal for dentures has an excellent effect of preventing discoloration and corrosion and can be used with confidence in metal fittings for partial dentures. Moreover, a denture cleaner with good storage stability can be obtained. By incorporating a granular anionic surfactant of 0.05 to 2 mm in an amount of 0.2 to 8% by weight of the whole formulation,
It was found that the discoloration / corrosion prevention effect of the metal for dentures can be further improved, and it becomes difficult to solidify even when stored under high temperature and high humidity conditions, and long-term storage stability can be further improved.

In this case, a combination of potassium hydrogen persulfate (component A) and sodium perborate (component B), and further a denture cleaner containing inorganic condensed phosphate added to these components,
Although various proposals have been made as described above, in general, a denture cleansing agent containing a peroxide improves discoloration power of a denture, and on the contrary, discoloration / corrosion action (damage) to metal for denture.
Also tends to increase. Further, in the above-mentioned combined use system of the components A and B, the component A has a high bleaching power, but since it is also harmful to the metal for the denture, it is difficult to use the component A alone. Therefore, in order to ensure excellent detergency, it is necessary to excessively blend the A component, and in fact, even in the conventional proposals described above, the A / B blending ratio is often the A component in excess. . Further, in order to suppress the harmful effect on the metal for denture, the absolute amount of A + B had to be suppressed as much as possible within the range of A / B in practical use.

On the other hand, the inorganic condensed phosphate is added under the high unit blending condition of the bleaching component such that the A component and the B component are in excess of the B component in the above ratio and the absolute amount of A + B is 45% by weight or more. When added at a specific ratio and dissolved in water (1
It has been surprisingly found that when the pH value of the (wt% concentration aqueous solution) is set to 8 to 11, it is possible to simultaneously satisfy the contradictory effects of discoloration / corrosion prevention effect on denture metal and excellent denture stain cleaning power.

It is well known to mix an anionic surfactant with a denture cleanser, for example, JP-A Nos. 62-8, 63-14714, and 63-10.
No. 1313, JP-A Nos. 1-125316 and 2-222.
No. 17, for example.

However, when a specific amount of a granular anionic surfactant having a specific average particle size is blended with the above-mentioned denture cleanser,
It is possible to prevent solidification of powder or granule preparations even after long-term storage under high temperature and high humidity conditions of storage at 75 ° C and 75% humidity for 3 months. Therefore, as described above, the oxygen-based bleaching component is coated with peroxide. It is a new finding of the present inventor that a denture stabilizer excellent in storage stability can be obtained by an inexpensive and simple operation without requiring a troublesome treatment such as treatment for stabilizing the bleaching component.

Further, in general, a foam type denture cleaner is
A carbon dioxide gas foaming method by an acid-alkali reaction in which an organic acid such as citric acid or sulfamic acid is reacted with an alkaline substance such as sodium bicarbonate or sodium carbonate to generate carbon dioxide is adopted. This action disintegrates tablets, granules, powder formulations,
Disperse and distribute the cleaning ingredients throughout the container. However, as in the case of the peroxide, the foaming component also consists of an acidic substance and an alkaline substance, so it is chemically unstable, and if the stabilization is insufficient, it induces gas evolution during storage, In some cases, the result may be unfavorable in terms of quality (for example, blistering of packaging material). Further, the addition of the foaming component not only increases the bulk of the preparation, but the treatment accompanied by stabilization leads to complication of production and increase in cost.

On the other hand, the cleaning agent of the present invention is not the carbon dioxide gas foaming method described above, but the organic acid is not added.
By combining an excess B component (alkaline) and a small amount of A component (acidic) and adjusting the pH value of a 1% by weight aqueous solution of the cleaning agent to 8 to 11, rich and fine oxygen bubbles (sodium perborate). (Oxygen generated by decomposition of oxygen) can be quickly spread throughout the cleaning container.Thus, the penetration of rich and fine oxygen bubbles contains active oxygen that is the source of the bleaching power, and the active oxygen is contained in the cleaning container. The present invention has been completed on the basis of the finding that it has an effect that it can be efficiently and instantaneously spread, and thus the cleaning power can be improved.

Therefore, the present invention does not contain an organic acid or a salt thereof as a foaming component, and potassium monopersulfate (A) and sodium perborate (B) as an oxygen-based bleaching component in a weight ratio of A / B = 1 / 4.5 to 1/10, A + B = 45
Denture cleaning, containing 5 to 30% by weight of the total amount of the inorganic condensed phosphate, and having a pH value of a 1% by weight aqueous solution of 8 to 11 Agent and this denture cleanser has an average particle size of 0.05 to 2 m
Provided is a denture cleansing agent containing m granular anionic surfactant.

The present invention will be described in more detail below. The denture cleanser of the present invention comprises an inorganic phosphoric acid condensation product with potassium monopersulfate (component A) and sodium perborate (component B) as oxygen-based bleaching components. It contains a salt.

In the detergent of the present invention, the mixing ratio of the above two kinds of oxygen-based bleaching agents is such that the component B is in excess of the component A in terms of preventing blackening of the denture metal and storage stability. However, considering the detergency, the weight ratio of A component / B component is 1 / 4.5 to 1/10, preferably 1
/4.5 to 1/9, more preferably 1 / 5.1 to 1/8
And Further, in the above blending ratio, the total blending amount of the components A and B needs to be 45% by weight or more, preferably 50 to 70% by weight based on the entire detergent. A component / B
When the compounding ratio of the components exceeds 1 / 4.1, the corrosion discoloration action on the denture metal becomes large, which is not preferable. In addition, the storage stability of the cleaning agent also deteriorates. Mixing ratio is 1/10
If it is less than the above, high cleaning performance is not exhibited, and the foamability when dropped in water is weak. Further, when the total amount of both components A and B is less than 45% by weight and the amount of component A / component B exceeds 1 / 4.1, high detergency cannot be obtained.

Under the above-mentioned blending conditions, the blending amount of the component A potassium hydrogen persulfate is from 1 to 10% of the total amount of the detergent.
19% by weight, especially 5 to 15% by weight is preferred. If the blending amount is less than 1% by weight, the effervescence when administered to water is weak and the granule preparation does not dissolve uniformly, so that satisfactory detergency may not be obtained. There is a risk of blackening.

The content of sodium perborate as component B is preferably 31 to 80% by weight, more preferably 35 to 60% by weight, based on the entire detergent. If the blending amount is less than 31% by weight, the amount of active oxygen is small and sufficient detergency may not be obtained.
If it exceeds 0% by weight, the cleaning effect reaches saturation, so that further addition may be meaningless.

Next, examples of the inorganic condensed phosphate include sodium pyrophosphate, acidic sodium polyphosphate, etc. These may be used alone or in combination of two or more kinds.

The content of the above-mentioned inorganic condensed phosphate is 5 to 30% by weight, preferably 8 to 20% by weight based on the whole detergent. When the content of the inorganic condensed phosphate is less than 5% by weight, the discoloration / corrosion inhibiting effect on the denture metal is not sufficient, and when it exceeds 30% by weight, the effect reaches saturation, which is meaningless.

Further, the denture cleanser of the present invention preferably contains a granular anionic surfactant. In this case, examples of the anionic surfactant include sulfate ester surfactants such as sodium lauryl sulfate and EO-added sodium alkyl ether sulfate, sodium dodecylbenzenesulfonate, sodium α-oleylsulfonate, sodium N-lauroylmethyltaurine, and the like. Sulfonic acid type surfactants, carboxylic acid type surfactants such as sodium lauroyl sarcosine, and phosphoric acid type surfactants such as EO-added sodium alkyl ether phosphate.

The average particle size of the above-mentioned granular anionic surfactant is preferably 0.05 to 2 mm, particularly 0.1 to 1.5 mm, and especially 0.2 to 1 mm. Average particle size is 0.05m
Even if it is less than m, even if it exceeds 2 mm, a satisfactory effect of preventing solidification during storage may not be obtained, and it is important to select an appropriate particle size in view of storage stability.

The blending amount of the above-mentioned granular anionic surfactant is preferably 0.2 to 8% by weight, particularly 0.5 to 5% by weight, based on the whole detergent, and the blending amount is less than 0.2% by weight. If it does not, the effect of preventing the cleaning agent from solidifying may become insufficient.
If it exceeds the weight%, the disappearance of bubbles in the washing container may be deteriorated.

In addition to the above components, other optional components can be added to the denture cleanser of the present invention. Specifically, surfactants other than the above anionic surfactants, for example, alkyl ether-based nonionic surfactants such as EO-added alkyl ethers, alkylphenyl ethers such as EO-added nonylphenyl ethers, and dialkyl ether-based nonionic surfactants. Nonionic surfactants such as The addition amount of the surfactant other than the anionic surfactant is preferably within the range that does not impair the effects of the present invention.

In the present invention, as described above, oxygen bubbles generated by decomposition of the B component are generated during cleaning. Therefore, organic acids such as citric acid and sulfamic acid, which are usually blended as a foaming component in denture cleaners, are used. And its salt are not mixed.

An enzyme may be further added to the toothpaste cleaner of the present invention. Examples of the enzyme include alkaline protease, dextranase, β-1,3-glucanase, mutanase, amylase and the like. .
The amount of the above enzyme added is preferably in the range of 0.01 to 10% by weight of the total detergent.

Further, as an optional component, for example, a binder such as polyvinylpyrrolidone, lactose or Avicel, various fragrances, dyes and the like can be blended. In addition, the addition amount of these optional components may be a normal amount within a range that does not impair the effects of the present invention.

The denture cleanser of the present invention may be prepared in a liquid form or, if necessary, prepared into a powder, granule or tablet dosage form, and dissolved in a solvent at the time of use to be used as a liquid form. However, in consideration of cleaning performance and harm to the skin, the pH value when dissolved in water (pH of a 1% by weight aqueous solution)
It is necessary to adjust the value to be 8 to 11, preferably 9 to 10.5. If the pH value when dissolved in water is less than 8, sufficient detergency cannot be obtained, and if the pH value exceeds 11, the safety of the hands and fingers due to alkali becomes a problem. The cleaning agent of the present invention thus exhibits the above pH range from immediately after being poured into water during use to the end of cleaning.
It has both excellent detergency and safety for the skin.

[0032]

EFFECT OF THE INVENTION The denture cleanser of the present invention is excellent in cleaning denture stains, especially stain stains such as tea astringent, and also excellent in preventing discoloration and corrosion of denture metal, and has good storage stability. It has, and can be effectively used for cleaning dentures.

[0033]

EXAMPLES The present invention will be specifically described below by showing experimental examples and examples, but the present invention is not limited to the following examples. In addition,% in each example is% by weight. The pH when dissolved in water is the pH of a 1% by weight aqueous solution of the detergent.

[Experimental Example 1] The denture cleansing agents shown in Table 1 were prepared, and the discoloration suppressing effect of the denture metal was evaluated by the following method.
The results are shown in Table 1. (1) Discoloration-suppressing effect of metal for dentures The surface of gold-silver-palladium alloy pieces (10 mm x 10 mm) was polished by sandblasting to remove the oxidized surface, and the color difference (E1) of the polished surface was measured. Next, after suspending the gold-silver-palladium alloy pieces in a beaker filled with 150 ml of distilled water (25 ° C), 3 g of the detergent sample shown in Table 2 was administered, and washing was performed for 2 hours while maintaining the temperature at 25 ° C. . The washed metal piece is washed with water, dried, and the color difference (E2) is measured.
The degree of color change (ΔE) was calculated according to the following formula and evaluated according to the following criteria. Discoloration Degree: ΔE = E2-E1 Evaluation Criteria ○: Less than 3 Δ: 3 or more and less than 6 ×: 6 or more From the results of Table 1, the denture cleaner of the present invention is excellent in the effect of suppressing discoloration of denture metal. Was confirmed.

[0035]

[Table 1]

[Experimental Example 2] A denture cleaner having the composition shown in Table 2 was prepared, and the effect of preventing solidification over time was evaluated by the following method. The results are shown in Table 2. Method for evaluating the effect of preventing solidification over time 100 g of a cleaning agent of each composition was placed in a 250 ml plastic bottle, and a hole having a diameter of 1 mm was opened in the lid of the plastic bottle.
It was stored in a thermo-hygrostat at 75 ° C. and RH. After 3 months, it was taken out and evaluated according to the following evaluation criteria. Evaluation Criteria ◯: Not solidified Δ: Slightly solidified ×: Solidified From the results in Table 2, it was found that the denture cleaner of the present invention has excellent storage and solidification stability.

[0037]

[Table 2]

[Experimental Example 3] Denture cleaners having the compositions shown in Table 3 were prepared and the tannin stain (tea astringent) cleansing power was evaluated by the following method. The results are shown in Table 3. (1) Preparation of tannin stain (brown astringent) dirt After the surface of an acrylic white plate (20 mm x 20 mm) was rough-polished by sandblasting, this plate was treated with an albumin solution, an aqueous tannin solution (an extract of Japanese tea, coffee, black tea), Sequential dipping in a ferric chloride solution was repeated to prepare tannin stain soil chips. (2) Evaluation of Detergency The color difference (E1) of the acrylic white plate and the color difference (E2) of the tannin stain stain chip prepared as described above were measured. The E2 tannin stain stain chip was hung in a beaker filled with 150 ml of distilled water (25 ° C.), 3 g of the detergent sample shown in Table 1 was administered, and a washing test was performed for 30 minutes while maintaining the temperature at 25 ° C.

Next, the washed dirt chips were washed with water and dried to measure the color difference (E3), and the washing ratio was calculated according to the following formula. The results are shown in Table 3. Tannin stain cleaning rate (%) = [(E3-E2) /
(E1-E2)] × 100 From the results in Table 3, it was confirmed that the denture cleanser of the present invention has excellent tannin stain (brown astringent) cleansing power, and particularly excellent speed cleaning effect in a short time.

[0040]

[Table 3]

Example 1 Potassium monopersulfate 8% Sodium perborate 48 Sodium tripolyphosphate 14 Sodium dodecylbenzene sulfonate granules 0.8 (average particle size 0.1 to 0.8 mm) Sodium bicarbonate balanced sodium carbonate 5 Alcalase 1 Dye Trace powdered fragrance 1 Total 100.0% (pH 9.95 when dissolved in water)

Example 2 Potassium monopersulfate 10% Sodium perborate 50 Sodium tripolyphosphate 20 Sodium lauryl sulfate granules 1.5 (average particle size 0.5 to 2 mm) Sodium carbonate balance alcalase 0.5 dextra Nase 0.5 Dye Micro powder fragrance 1 Total 100.0% (pH 10.4 when dissolved in water)

[0043]

[Example 3] Potassium monopersulfate 5% Sodium perborate 50 Sodium tripolyphosphate 15 Sodium dodecylbenzene sulfonate granules 1 (average particle diameter 0.1 to 1.5 mm) Sodium carbonate balance alcalase 1 dye Trace amount Powdered fragrance 1 total 100.0% (pH when dissolved in water 10.65)

[0045]

─────────────────────────────────────────────────── --- Continuation of front page (56) References JP-A-55-55110 (JP, A) JP-A-61-225116 (JP, A) JP-A-63-86799 (JP, A) International Publication 95/015145 (WO, A1) (58) Fields investigated (Int.Cl. ⁷ , DB name) A61K ^7/ 00-7/50

Claims (2)

(57) [Claims] 1. An organic acid or a salt thereof as a foaming component is not contained, and potassium monopersulfate (A) and sodium perborate (B) are used as oxygen bleaching components in a weight ratio of A / B =.
1 to 4.5 to 1/10, A + B = 45% by weight or more, and contains 5 to 30% of the inorganic condensed phosphate.
1% by weight aqueous solution has a pH value of 8
A denture cleanser characterized by being -11. 2. The denture cleansing agent according to claim 1, wherein a granular anionic surfactant having an average particle size of 0.05 to 2 mm is blended in an amount of 0.2 to 8% by weight based on the entire cleansing agent.